Sinemet and clonazepam

Anyone with Parkinson’s also fighting Benzodiazepine withdrawal / recovery?

2021.05.11 00:36 sickntired00 Anyone with Parkinson’s also fighting Benzodiazepine withdrawal / recovery?

I have had Parkinson’s for about 9-10 years. About 5 years ago I was prescribed alprazolam (Xanax) to help with sleep. I also noticed it helped with nausea related to Sinemet (which I no longer need to take since having DBS surgery 2 years ago). But the sleep issues persist. Alprazolam still helped some but in retrospect I noticed I was not sleeping more than 2 or 3 hours at a stretch.
I started getting very very sick last fall...nobody knew what was going on. Doctors had me trying 3-4 different psych drugs try one, try another etc. (to no avail). I finally figured out it was the alprazolam, but it took a while to convince doctors. In Jan I was switched to Clonazepam, a longer acting benzo that me allows me to sleep through the night...but still something I need to get off of, so I am tapering off from .5mg. It is brutal. Agonizing. My DBS brain surgery was a cakewalk, compared to this evil experience.
I cannot find info if i am even able to properly heal due to Parkinson’s...I don’t know if there is a connection between dopamine neurotransmitters and GABA that may affect my recovery from benzodiazepines.
From benzoinfo.com:
Neuroadaptation occurs with patients on daily prescribed benzodiazepines. This means that their bodies adapt through repeated exposure to a drug, producing long-term changes in the nervous system. Neuroadaptation to the benzodiazepine’s constant presence is the reason for the development of tolerance and a sensitization of the nervous system. The continual presence of prescribed benzodiazepine may cause down-regulation of the GABA receptors, meaning that the receptors become fewer. This is believed to be from the homeostatic response of the body to the constant presence of the benzodiazepines. When those who have benzodiazepine neuroadaptation try to stop a benzodiazepine, the nervous system can go into a chronic hyperactive state. The taking of the benzodiazepine has made the body unable to properly utilize GABA. This nervous system reaction can occur on the benzodiazepines, in tolerance withdrawal, when stopping benzodiazepines, or after being completely withdrawn. While the nervous system is in a hyperactive state of tolerance, toxicity, withdrawal, or protracted withdrawal, patients anecdotally report having reactions to certain substances, even if they previously tolerated them, and setbacks from these reactions.
submitted by sickntired00 to Parkinsons [link] [comments]


2019.11.11 15:39 vicki5150 Advice with medication

Hi everyone. My friend has cerebral palsy and dystonia. He communicates with a letter board but lately (roughly the last month) his dystonia has been putting his body into complete lockdown and limiting the use of his arms. As you can imagine, it’s incredibly difficult for him as he needs the use of his arms to communicate.
He has been on L-Dopa (sinemet) for 6 years and for the past 4 months has also been on clonazepam. Is there anyone who has been on similar drugs? Or had similar experiences? Or can recommend something that might help him?
submitted by vicki5150 to Dystonia [link] [comments]


2019.01.02 18:42 AnthonyRoberson I Have Parkinson's And My 'Off' Periods Are Suddenly Getting Longer - HELP!

I am a 51 year old Male and I have been diagnosed with Parkinson's Disease for about four years now. I take Sinemet, Amantadine, Selgeline and Clonazepam for sleep. My symptoms are mostly right side rigidity, overall pain and trouble sleeping.
I have done remarkably well up until several months ago. I basically took my meds and went on with my life for the most part. However, over the last couple of months, my 'off' periods have suddenly started getting longer. I used to take meds at 7 am and I was good until 12 or 1 pm. Now I am starting to go 'off' by 11 am and so I have to take meds early. This means I go 'off' again before I leave work and it makes it rather hard to drive home...
I am not asking for a medical opinion or advice. I just want to know if anyone that fits my demographic has had a similar experience and what, if anything, they did to help it. I have started walking some but I hurt so bad most of the time that it makes it difficult.
I am pretty despondent at this point. I really can't afford to lose my job but it is getting harder and harder just to make it through the day. Any advice or assistance would be most appreciated.
submitted by AnthonyRoberson to Parkinsons [link] [comments]


http://rodzice.org/