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2021.10.24 16:53 VinDieselArk MultiVersus

Free-to-play platform fighter MultiVersus with Cross-Play for PS5, Xbox Series, PS4, Xbox One, and PC by Warner Brothers. LAUNCHING MAY 28, 2024
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2012.04.10 04:26 Overlord

Overlord Anime/Manga/Novel Discussion. Spoilers for Anime-Onlys.
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2008.12.10 09:23 Starcraft on Reddit

All about the StarCraft games and professional scenes surrounding them. Please read the rules before submitting content.
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2024.06.07 23:31 DigitalSheikh Kratom and Testosterone: A short primer

I wanted to put this together to provide a resource that people can use to understand how kratom might be linked to hypogonadism in men. It’s a very poorly understood issue in need of better research - while there’s a clear theoretical link between kratom and hypogonadism, studies have not consistently demonstrated it in practice, and there are a number of reasons to believe that the impact of low-moderate kratom use might not be as large as many people claim. That said, I want to emphasize that this is not-scientific level writing, and I am not a scientist. I just read some papers and am editorializing my conclusions from them, take them as you may. If you’re interested in the topic, I hope you find it interesting.

What is Kratom?

Kratom is the leaf of a tree that grows across Southeast Asia, in the same family of plants as the coffee bush. Within Southeast Asia, the most common method of consumption is simply taking leaves off the tree and chewing them, but in the US, it is more common to either consume dried, powdered leaves, or to make the leaves into a tea. Users report that kratom induces euphoric mood, higher energy, and greater alertness in lower doses, while larger doses induce analgesia (pain-relief) and relaxation. These anecdotal and contradictory findings are somewhat supported by our early understanding of kratom’s impact on dopamine release, but are still poorly understood. (Johnson LE)
In Thailand, Kratom has historically been used by manual laborers as a means of warding off exhaustion and fighting pain. In the US, Kratom is typically used for pain (91%), anxiety (67%), and depression (65%), with high ratings of effectiveness. (Garcia-Romeu A) Additionally, many users (20-30%, depending on the study) report taking kratom as a means to alleviate withdrawal symptoms from other opiates.
There is considerable conflict in analysis of kratom’s safety and efficacy. This Mayo clinic article is a good aggregate of the potential negative side effects of Kratom, but an observant reader will note that they do not cite any studies or peer reviewed research when making their claims. As far as I can tell, most of the claims they make are based on single-case reports of users who usually have significant comorbid health problems, or who are simultaneously abusing traditional opiates or drinking heavily. That said, it would not be wise to dismiss the potential negative health consequences of kratom out of hand - larger surveys have certainly confirmed that kratom is a substance with significant abuse potential, causes dependency and withdrawal, and can in higher doses cause many of the problems one would expect in a traditional opioid user. (Garcia-Romeu A) It may also be linked, as traditional opiates are, to hypogonadism (low-T) in men.

Kratom vs. other Opiates

Kratom’s active ingredients are mitragynine and 7-hydroxymitragynine, both partial opioid agonists that act primarily on the Mu opioid receptor, as opposed to traditional opioids like heroin or morphine that act on the Kappa, and Delta opioid receptors much more than mitragynine does. As a result, kratom is generally considered to have significantly less potency than traditional opioids, especially in terms of dangerous respiratory depression.
However, mitragyinine potentially impacts other brain processes, such as inhibiting D2 dopamine, alpha-2 adrenergic, and serotonin receptors. (Johnson LE, though this is only as a source for the studies they cite on this) Traditional opioids are not shown to interact with these systems, except perhaps indirectly. More to our point, both kratom and traditional opioids are theorized to inhibit the release of GnRH, the precursor hormone that stimulates Lutenizing Hormone and Folicle Stimulating Hormone release. These hormones stimulate testosterone production, which is the theoretical pathway by which opioids can cause hypogonadism.
These findings might potentially influence how a kratom user’s bloodwork would look versus a traditional opioid user - considering that inhibiting D2 dopamine should theoretically inhibit prolactin release, a kratom user might expect to see lower testosterone without a corresponding increase in prolactin that most practitioners will use to diagnose opioid-induced hypogonadism, as opioids usually stimulate prolactin release. However, that’s just a theory.

Kratom and Hypogonadism: What do we know?

In short, much less than we’d like. Research is very sparse, so the main point is to caution one against drawing too many conclusions about kratom’s impact on hypogonadism. Let’s start with the single most cited study on the topic: “Kratom, an Emerging Drug of Abuse, Raises Prolactin and Causes Secondary Hypogonadism: Case Report”. This study appears everywhere when you search for information on the topic, but it really shouldn’t be. It covers the case of a single user, which apparently was enough for the authors to confidently conclude that kratom definitely causes hypogonadism and elevated prolactin levels. It doesn’t cover why the patient began taking kratom, and only notes that the patient’s levels returned to normal after stopping, not whether their symptoms resolved. Nor does it cover any other possible comorbidities or any other factors that may have influenced any aspect of the case. It is a case study in poor scientific writing that undoubtably has influenced a lot of people’s opinions on the topic.
Better research on the issue is not without its problems though. The only study with more than one participant followed daily Kratom users over the course of two years, finding that Kratom use equivalent to around 2 grams per day had no statistically significant impact on testosterone levels in men. (Darshan Singh) However, 2 grams per day isn’t the best representation of typical consumption patterns, at least in the US, as other studies have found that most users report using 3-5 grams per day or more. (Deebel, N. A.)
The same study that I cite for typical consumption patterns looked instead at markers of male sexual health in relation to Kratom use. The finding that I find easiest to translate to potential hypogonadism, is that confusingly 42% of patients reported an increase in desire and enjoyment of sexual activity, while 37.8% reported the opposite. However, participants did consistently report a significantly increased time to ejaculation. Lastly, it found that 1.9% of participants reported a low testosterone diagnosis after beginning kratom, but there’s not much that can be made of that considering that the participants were not required to test for it. (Deebel, N. A.)
Lastly, we can turn to general opioid research to make some generalizations about how kratom might impact a user’s testosterone levels. Studies consistently confirm that longer-acting opioids appear to lower testosterone levels much more significantly than short-acting ones, with one study finding that 74% of men on long-acting opioids were hypogonadal, vs 34% on short-acting. As kratom is more akin to a short-acting opioid, it is reasonable to theorize that the impact of kratom on testosterone is at least more in line with other short-acting opioids.
In conclusion, research on this topic is in the extremely early stages. In terms of how we view kratom in terms of hypogonadism, I would caution people to avoid automatically attributing kratom use to a user’s hypogonadism, but to also understand that there is definitely a link between these issues. Anecdotally, it seems clear that users taking very high doses of kratom will almost certainly experience issues with their hormones, but such a link is more tenuous in low-moderate users. This would be in line with kratom’s significantly lower potency, and much more limited impact on opioid receptors as a whole.

Pain, Testosterone, and Hypogonadism: Wild Theorizing.

Having done this research, I began to leave kratom aside and wonder whether there might be significant group of men who were not hypogonadal because of opioid use, but rather were seeking opioids because of their hypogonadism. This question is important to me specifically because prior to starting TRT I was completely dependent on kratom to control various pains that were significant enough to impair my life. Just two weeks after beginning TRT, I was able to discontinue kratom without any negative side effects or any recurrence of pain. I was cured. But is my case actually representative of anything?
Testosterone has been theorized, mostly based off non-human studies, to be analgesic (pain-reducing) in three ways:
  1. Direct Analgesia: Testosterone may reduce pain directly through its interaction with androgen receptors.
  2. Action on Endogenous Opioid Receptors: Testosterone can enhance the activity of the endogenous (“natural”) opioid system, which includes endorphins and enkephalins. These natural painkillers bind to opioid receptors and reduce pain perception.
  3. Reduction of Inflammation: Testosterone has anti-inflammatory properties. It can reduce the production of pro-inflammatory cytokines and other inflammatory mediators, which play a significant role in pain, especially in conditions like arthritis and chronic inflammatory diseases.
Theoretically then, it would make sense that hypogonadal men experience greater amounts of pain than their non-hypogonadal counterparts, and might subsequently turn to opiates in an attempt to alleviate their symptoms. To me, the argument becomes especially compelling when looked at in terms of testosterone’s effect on endogenous opioid receptors - it might be possible that users are attracted to opioids as an attempt to replace the missing function of testosterone.
However, in terms of research, there isn’t a lot to go on to evaluate that theory. An unfortunate aspect of current human research on testosterone and pain is that there appear to be no studies whatsoever on patients who are not also using opiates for pain-management. Since patients who are admitted to pain-management programs usually have serious health conditions that necessitate it, studies focusing on them don’t have much to say about the general aches and pains that one “shouldn’t be experiencing” that I and many others have found testosterone helpful with.
With that noted, the studies are ultimately mixed. This one and this one found that testosterone therapy significantly reduced reported pain, while this one (which I found to be of much higher quality methodologically) found no statistical effect. I hope that at some point in the future research will be produced that looks at reported pain among non-opioid users and compares that to testosterone levels, it might help us evaluate the question much more scientifically.
submitted by DigitalSheikh to Testosterone [link] [comments]


2024.06.07 22:49 lifeondearth Any advice for serializing a novel on Substack?

I would be interested in anyone's experiences with serializing a novel on Substack, or other venue, which I have recently launched myself into with my literary thriller novel "Most Revolutionary."
At risk, Mods, of self promo, I'd like to point to a recent post to substack apart from the novel serialization that concisely summarizes what I've learned over many years of studying the craft and art of stories, by way of MFA training, Hollywood script writing training, and personal research: "The Energy of Story: Brief Notes On Basic Story -- A Story Toolkit for Authors & Creators." Apart from what's written in that post, I'll add that I gained huge insight on writing once I learned to both adapt a novel to script form and to adapt a script to novel form. Basically I found that script writing gives you insight into the structure of novel writing, gives it more compelling structure, while novel writing pushes scripts to have more depth and thematic integrity than usual. And I'm wondering is there similar insight to be gained from weekly serializing a novel online versus publishing it all at once online. I suspect a lot will be learned through the serialization process and wonder if anyone who has completely gone through it before would share what that might be?
submitted by lifeondearth to authors [link] [comments]


2024.06.07 22:32 srgwml [WTS] HK MP5 dated magazine and Hiperfire AK Mark-2 trigger

Timestamp: https://imgur.com/a/QxY8wGH
Up for sale is a few items collecting dust and taking up space.
  1. HK MP5 magazine, dated 11/77. Awesome magazine in excellent condition. Cool as well showing "MP5 HK 11/77" versus your normal date codes. - $110 shipped
  2. Hiperfire AK Trigger Mark-2. Brand new in packaging. $65 shipped.
Payment methods accepted are Venmo, CashApp, Zelle, or PayPal FF only... Absolutely no notes.
submitted by srgwml to GunAccessoriesForSale [link] [comments]


2024.06.07 21:09 CapBNSU Apollo’s Dawn: Wasteland Warfare

Apollo’s Dawn: Wasteland Warfare
🚀 Join Apollo’s Dawn: Wasteland Warfare Discord Community! 🚀
🔥 Embark on an Epic Journey: Explore a world ravaged by apocalypse, where survival is key and every decision matters.
🌟 Why Join Our Discord?
• Roleplaying Welcome: Roleplaying is encouraged and welcomed in our server! • Connect with Fellow Survivors: Chat with like-minded players, forge alliances, and strategize your next move. • Exclusive Announcements: Be the first to know about updates, events, and giveaways. • Airdrop Mechanics: Call in airdrops via walkie-talkie, but beware - one loud sound can attract hordes of zombies! • City Securing Challenges: Cleaning up a city isn’t enough; without secure walls, it could cost you your life. • Dynamic Environment: Loot respawns every 7 days in real life, ensuring a constantly evolving world.• Protected Safehouses: Build and fortify safehouses for protection against both zombies and other players. (Safehouses cannot be raided at the moment) • Endless Exploration: Tons of locations to discover and conquer, with minimal rules and no staff team breathing down your neck. • Personal Attention: As a one-man army, please allow time for any questions or concerns you have upon joining the server. Your patience is appreciated! • Growing Community: We’re still a new server with only 3 active players at the moment, but we hope you’ll join us and become one of the active players! • PvP and PvE: Engage in intense player versus player combat or team up against the undead menace. • Mod Warning: Please note that our server includes a lot of mods. If you prefer not to play with a lot of mods, this might not be the right fit for you.
🔗 Join Now: https://discord.gg/dKaTjt7S8D
🌐 IP Address: [173.0.159.148 27135]
Join the Apollo’s Dawn: Wasteland Warfare Discord community today and become part of the ultimate post-apocalyptic experience!
submitted by CapBNSU to projectzomboid [link] [comments]


2024.06.07 21:09 Zrothum S1 Installer Datto RMM

Is there an easier way to do this yet versus using site variables like Best Way to Deploy Sentinel1 via Datto . : Autotask (reddit.com)
submitted by Zrothum to DattoRMM [link] [comments]


2024.06.07 20:50 beattyj Concealment shelf from Tactical Walls -anyone tried with the 1301?

Curious about this:
https://tacticalwalls.com/product/1242-top-locking-shelf/
I've got a 1301 Comp 21 5-shot setup with all the typical stuff for home defense, the Briley forend, a flashlight, a few 6 round Esstac shotgun cards, a Holosun 507Cx2, a match saver, the Magpul stock, and a Blue Force Vickers sling. It's taken a little bit to get comfy with all of it but it now feels setup right, but it's a bit on the heavy/bulky side.
With all of it on there, it's really pushing the dimensions of what may fit in this concealment shelf, but I'm thinking of giving it a shot as it fits the decor and based on where I'd put it, and seems to strike a very good balance in terms of convienient versus out of casual view. Because it's head-height and horizontal, and I'd be fumbling for it at night, it would still be loaded 'cruiser ready' without a round in the chamber. Would likely just leave the magnets in 'open' position most of the time, moving and hiding them if there's visitors likely to be wandering a bit.
I have a proper safe too but it's somewhat far from the bedroom, it's not quick-access, and it's more for secure storage when the cleaning ladies are over or when the nephews are unsupervised and so on. So I wanted something more handy and quick but not too obvious, and this seemed to fit the bill.
Anyone tried using this shelf with the 1301 tactical and have any positive/negative reviews?
The alternative is this one from Fort Knox, but it'd be on the floor and a little less convenient to get out and ready, and a little more obvious that it's hiding something valuable. https://www.amazon.com/Fort-Knox-Shotgun-Safe-Rifle/dp/B01BW262GU/
submitted by beattyj to beretta1301 [link] [comments]


2024.06.07 20:50 TOOTIMMY1723 " Lands Of Undaria" The Ps Rp experience

Server Name: *Lands Of Undaria * Server Region: US Server type: PvP-RP Server Lore: Classic R.E Howard Platform: PlayStation Server map: Exlies Age Restrictions: 18+ only
Server Description: Discover the Lands of Undaria – The Ultimate RP-PvP Experience!
Step into a world where your story is yours to create, your battles are yours to win, and your legacy is yours to forge. Welcome to Lands of Undaria, the premier RP-PvP server where role-playing and player versus player combat blend seamlessly for an unparalleled gaming adventure.
Why Choose Lands of Undaria?
🌍 Immersive World: Explore a meticulously crafted realm filled with diverse landscapes, rich lore, and endless opportunities for adventure. From bustling cities to treacherous dungeons, every corner of Undaria is designed to captivate your imagination.
🛡️ Dynamic PvP Combat: Engage in thrilling battles against other players, where strategy, skill, and quick thinking are key. Whether you’re defending your territory or raiding an enemy stronghold, the excitement never ends.
🗣️ Deep Role-Playing: Create and develop your character with intricate backstories, alliances, and rivalries. Participate in server-wide events, quests, and storylines that evolve based on player actions.
⚔️ Custom Features: Enjoy unique mechanics and custom content that enhance your gameplay experience. From specialized classes to rare artifacts, Undaria offers a plethora of features you won’t find anywhere else.
🏆 Active Community: Join a vibrant community of like-minded players and dedicated staff. Our active forums and Discord server provide the perfect platform for discussing strategies, sharing stories, and making new friends.
Join the Adventure Today!
Are you ready to carve your path in a world of endless possibilities? Visit Lands of Undaria to learn more and start your journey. Your legend begins here!
Lands of Undaria – Where Every Hero Has a Story
https://discord.com/invite/MbUJP8XFFN
submitted by TOOTIMMY1723 to ConanExilesServers [link] [comments]


2024.06.07 20:30 slw-dwn 🌌 Jupiter’s End of Week Discussion The Week of 6/7/2024

What's going on Catdets 🐈 🪐
It’s time for our end of week recap and discussion, let’s get into it!

A Few Exciting Updates!

Here are just a few of the many exciting updates happening week by week in the Jupiter ecosystem:
Shifting Crypto Communities From a Player Versus Player(PVP) To Player Pump Player(PPP) Mindset
• A shift from the common crypto mind set, backed by Jupiter founder u/weremeow, in an effort to bring more inclusivity and an all around fair playing field for those in crypto communities.
• Read the article written by Meow here, highlighting important factors of the how Player Pump Player mind set is key for the growth of crypto communities, why it's essential and how crypto can benefit from the change of moving away from the Player Versus Player mentality.
Jupiter Perps Trading Fees Adjusted
• The open/close fees were reduced from 0.1% to 0.07%.
• Introduced a new Price Impact Fee structure where the larger the trade, the higher the fees.
• JLP now earns 75% of these trading fees.
• With these changes, most Jupiter traders will pay less in fees and you can also split up your trade to incur less impact. These changes were recommended by Gauntlet, with the goal of ultimately increasing trading volume and improving APY for JLP.
• More details on the Jupiter Research Forum here and the original post on X by Jupiter Exchange here.
User Protection From Imposter Tokens
• To ensure user safety, Jupiter has stopped displaying tokens that mimic names and symbols of legitimate assets
• The team is also working on upgrades to help users discover new tokens quickly and securely. Stay tuned for more exciting updates!
Uplink Working Group Bounty
• Create a 30-90 second video on key points from Meow’s interview with Anatoly which can be found here.
Bounty Details and Submission: There is up to 1050 $JUP in rewards up for grabs!
• Prizes are available for the best videos and the most viewed video.
• View the original post regarding the Uplink Working Group Bounty by u/OrganizdGeneral here.

Apart from the updates, some questions for everyone:

How has your week been?
Did you have any trading highlights this week?
What was the most interesting crypto news you came across this week?
Share your experiences from the past week, let’s hear how things have been going for you!

P.S. Missed the Live Planetary Call?

Today’s weekly Planetary Call featured some special guests from the following projects: Galactic Geckos, WEN, Tremp, Sharkcat, PonkeSOL, Moutai, MockJUP. Get up to date on everything discussed earlier today by u/kash_dhanda & u/weremeow involving healthy community building, the PPP mentality and more by watching the recording on YouTube here!
submitted by slw-dwn to jupiterexchange [link] [comments]


2024.06.07 20:00 Temporary_Noise_4014 NurExone Biologic Inc - LitchField Hills Research Report (TSXV: NRX, OTCQB: NRXBF, FSE: J90, NRX.V)

NurExone Biologic Inc - LitchField Hills Research Report (TSXV: NRX, OTCQB: NRXBF, FSE: J90, NRX.V) submitted by Temporary_Noise_4014 to smallcapbets [link] [comments]


2024.06.07 19:51 bonusminutes We're we not supposed to get another character leveling event today?

We had the one before themed around... Wonder Women lifting? But there was some discussion about another one starting June 7th. That's today and nothings there. What happened?
Edit: I got the date wrong and it was just someone guessing: https://www.reddit.com/MultiVersus/s/OBXXa1RqCX
submitted by bonusminutes to MultiVersus [link] [comments]


2024.06.07 19:20 calvin324hk [H] 1000+ Games / DLCs / VR Games [W] Paypal / Wishlist / Offers

https://www.reddit.com/IGSRep/comments/pikmri/calvin324hks_igs_rep_page/
https://www.reddit.com/sgsflaicomments/of2wzu/flair_profile_ucalvin324hk/
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Region: NA (Canada)
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  • The Walking Dead: Season 1
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  • Three Kingdom: The Journey
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  • TINY TINA'S WONDERLANDS CHAOTIC GREAT EDITION
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  • Vampire - The Masquerade: Shadows of New York
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  • Velocity Noodle
  • Venba
  • Verne: The Shape of Fantasy
  • Victoria 3
  • Victoria II
  • Viking: Battle For Asgard
  • Virgo Versus The Zodiac
  • VirtuaVerse
  • Visage
  • Viscerafest
  • VOIDIGO
  • Volcanoids
  • Voltage High Society
  • V-Rally 4
  • Wanderlust: Travel Stories (GOG)
  • Wanted: Dead
  • Wargroove
  • Warhammer 40,000 Sanctus Reach - Complete Edition
  • Warhammer 40,000: Armageddon - Imperium Complete
  • Warhammer 40,000: Battlesector
  • Warhammer 40,000: Gladius - Relics of War
  • Warhammer 40,000: Space Wolf Special Edition
  • WARHAMMER AGE OF SIGMAR: REALMS OF RUIN – ULTIMATE EDITION
  • Warhammer: End Times - Vermintide
  • Warhammer: Vermintide 2
  • Warman
  • Warstone TD
  • Wasteland 3
  • Wayward
  • WE NEED TO GO DEEPER
  • We should talk.
  • We Were Here Together
  • We Were Here Too
  • Webbed
  • Werewolf: The Apocalypse Heart of the Forest
  • West of Dead
  • What Lies in the Multiverse
  • When Ski Lifts Go Wrong
  • while True: learn()
  • Whos Your daddy
  • Wick
  • Windward
  • Witch It
  • Witchy Life Story
  • Wizard of Legend
  • wizard of legends
  • Worms Rumble
  • Worms Rumble + Legends Pack
  • Wrath: Aeon of Ruin
  • WRC 6 FIA World Rally Championship
  • WRC 7 FIA World Rally Championship
  • WWE 2K Battlegrounds
  • WWE 2K23
  • WWZ Aftermath
  • Wytchwood
  • X-COM: COMPLETE PACK
  • XCOM: ULTIMATE COLLECTION
  • XIII - Classic
  • X-Morph: Defense
  • X-Morph: Defense + European Assault, Survival of the Fittest, and Last Bastion DLC
  • X-Morph: Defense Complete Pack
  • Yakuza Kiwami
  • Yakuza: Like A Dragon
  • Yumeutsutsu Re:After
  • Yumeutsutsu Re:Master
  • Zen Chess: Mate in One, Mate in 2 , Mate in 3 , Mate in 4 , Champion's Moves (5 games)
  • Ziggurat
  • Zombie Army 4
  • Zombie Army Trilogy
  • Zool Redimensioned
  • Zwei: The Arges adventure
  • Zwei: The ilvard insurrection
DLCs and Softwares:
  • For The King: Lost Civilization Adventure Pack
  • Train Simulator: Isle of Wight Route Add-On
  • Train Simulator: Woodhead Electric Railway in Blue Route Add-On
  • Train Simulator: North Somerset Railway Route Add-On
  • Train Simulator: Union Pacific Heritage SD70ACes Loco Add-On
  • Train Simulator: London to Brighton Route Add-On
  • BR Class 170 'Turbostar' DMU Add-On
  • DB BR 648 Loco Add-On
  • Europa Universalis IV: Wealth of Nations
  • Expansion - Europa Universalis IV: Conquest of Paradise
  • Expansion - Europa Universalis IV: Res Publica
  • Grand Central Class 180 'Adelante' DMU Add-On
  • Peninsula Corridor: San Francisco - Gilroy Route Add-On
  • SONIC ADVENTURE 2: BATTLE
  • Small World - A Spider's Web
  • Small World - Cursed
  • Small World - Royal Bonus
  • The Dungeon Of Naheulbeuk: The Amulet Of Chaos - Goodies Pack
  • The Dungeon Of Naheulbeuk: The Amulet Of Chaos - OST
  • Thompson Class B1 Loco Add-On
  • Total War: Shogun 2 - Rise of the Samurai
  • Train Sim World® 3: Birmingham Cross-city line
  • Train Sim World®: BR Class 20 'Chopper' Loco
  • Train Sim World®: Brighton Main Line: London Victoria - Brighton
  • Train Sim World®: Caltrain MP36PH-3C 'Baby Bullet'
  • Train Sim World®: Cathcart Circle Line: Glasgow - Newton & Neilston
  • Train Sim World®: Clinchfield Railroad: Elkhorn - Dante
  • Train Sim World®: Great Western Express
  • Train Sim World®: Hauptstrecke Hamburg - Lubeck
  • Train Sim World®: LIRR M3 EMU
  • Train Sim World®: Long Island Rail Road: New York - Hicksville
  • Train Sim World®: Nahverkehr Dresden - Riesa
  • Train Sim World®: Northern Trans-Pennine: Manchester - Leeds
  • Train Sim World®: Peninsula Corridor: San Francisco - San Jose
  • Train Sim World®: Rhein-Ruhr Osten: Wuppertal - Hagen
  • Train Sim World®: Tees Valley Line: Darlington - Saltburn-by-the-sea
  • Worms Rumble - Armageddon Weapon Skin Pack
  • Worms Rumble - Captain & Shark Double Pack
  • Worms Rumble - Legends Pack
  • Worms Rumble - New Challengers Pack
  • Ashampoo Photo Optimizer 7
  • Dagon: by H. P. Lovecraft - The Eldritch Box DLC
  • Duke Nukem Forever Hail to the Icons
  • Duke Nukem Forever The Doctor Who Cloned Me
  • GRIP: Combat Racing - Cygon Garage Kit
  • GRIP: Combat Racing - Nyvoss Garage Kit
  • GRIP: Combat Racing - Terra Garage Kit
  • GRIP: Combat Racing - Vintek Garage Kit
  • GameGuru
  • GameMaker Studio 2 Creator 12 Months
  • Intro to Game Development with Unity
  • Music Maker EDM Edition
  • Neverwinter Nights: Darkness Over Daggerford
  • Neverwinter Nights: Enhanced Edition Dark Dreams of Furiae
  • Neverwinter Nights: Enhanced Edition Tyrants of the Moonsea
  • Neverwinter Nights: Enhanced Edition
  • Neverwinter Nights: Infinite Dungeons
  • Neverwinter Nights: Pirates of the Sword Coast
  • Neverwinter Nights: Wyvern Crown of Cormyr
  • PDF-Suite 1 Year License
  • Pathfinder Second Edition Core Rulebook and Starfinder Core Rulebook
  • RPG Maker VX
  • WWE 2K BATTLEGROUNDS - Ultimate Brawlers Pass
  • We Are Alright
  • The Outer Worlds Expansion Pass
  • A Hat in Time - Seal the Deal DLC
  • City Skylines:mass transit
  • A Game Of Thrones - A Dance With Dragons
  • A Game Of Thrones - A Feast For Crows
  • Blood Rage: Digital Edition - Gods of Asgard
  • Blood Rage: Digital Edition - Mythical Monsters
  • Blood Rage: Digital Edition - Mystics of Midgard
  • Carcassonne - The Princess and The Dragon DLC
  • Carcassonne - Traders & Builders DLC
  • Carcassonne - Winter & Gingerbread Man DLC
  • Carcassonne - Inns & Cathedrals
  • Carcassonne - The River
  • Splendor: The Trading Posts DLC
  • Splendor: The Strongholds DLC
  • Splendor: The Cities DLC
  • Small World - Be Not Afraid... DLC
  • Small World - Grand Dames DLC
  • Small World - Cursed!
  • Sands of Salzaar - The Ember Saga
  • Sands of Salzaar - The Tournament
  • Monster Train: The Last Divinity DLC
  • WARSAW
submitted by calvin324hk to indiegameswap [link] [comments]


2024.06.07 19:20 calvin324hk [H] 1000+ Games / DLCs / VR Games [W] Paypal / Wishlist / Offers

https://www.reddit.com/IGSRep/comments/pikmri/calvin324hks_igs_rep_page/
https://www.reddit.com/sgsflaicomments/of2wzu/flair_profile_ucalvin324hk/
Wishlist
Region: NA (Canada)
Fees on buyer if any, currency is USD unless specified
CTRL + F to find your games in terms of name
  • >observer_
  • 10 Second Ninja X
  • 11-11 Memories Retold
  • 112 Operator
  • 12 is Better Than 6
  • 198X
  • 1993 Space Machine
  • 60 Parsecs
  • 7 Billion Humans
  • 8 DOORS
  • 8-bit Adventure Anthology: Volume I
  • 9 Years of Shadows
  • 911 Operator
  • A Game of Thrones: The Board Game
  • A Hat in Time
  • A Hole New World
  • A JUGGLER'S TALE
  • A Long Way Down
  • A PLAGUE TALE: INNOCENCE
  • A Robot Named Fight!
  • A Tale for Anna
  • A.I.M.2 Clan Wars
  • Abalon (Summoners Fate)
  • Above Snakes
  • ABZU
  • Ace Combat Assault Horizon Enhanced Edition
  • ADOM
  • Adore
  • Adventure Time: Pirates of the Enchiridion
  • Aeterna Noctis
  • AETHERIS
  • Agatha Christie Hercule Poirot The First Cases
  • AI War 2
  • AIdol
  • Airborne Kingdom
  • Alba: A Wildlife Adventure
  • Alder's Blood: Definitive Edition
  • Alfred Hitchcock - Vertigo
  • Alien Breed Trilogy
  • Aliens vs. Predator™ Collection
  • All-Star Fruit Racing
  • Almost There: The Platformer
  • American Fugitive
  • American Truck Simulator
  • Amerzone: The Explorer’s Legacy
  • AMID EVIL
  • Amnesia rebirth
  • Amnesia: The Dark Descent + Amnesia: A Machine for Pigs
  • Anomalous
  • Another World – 20th Anniversary Edition
  • Antigraviator
  • Anuchard
  • APICO
  • APICO
  • Aragami
  • Aragami 2
  • Arboria
  • Arcade Paradise
  • Arcade Paradise - Arcade Paradise EP
  • Arcade Spirits
  • Arkham Horror: Mother's Embrace
  • Armada 2526 Gold Edition
  • Army Men RTS
  • army of ruin
  • Arto
  • Ary and the Secret of Seasons
  • As Far as the Eye
  • Ascension to the Throne
  • Assemble With Care
  • Assetto Corsa Competizione
  • Assetto Corsa Ultimate Edition
  • Astebreed Definitive Edition
  • Astronarch
  • Attack of the Earthlings
  • Automachef
  • Automobilista
  • Automobilista 2
  • AUTONAUTS
  • AUTONAUTS VS PIRATEBOTS
  • Avatar: Frontiers of Pandora™ - Ubisoft Connect
  • AVICII Invector: Encore Edition
  • Awesomenauts All Nauts pack
  • Axiom Verge
  • Axiom Verge 2
  • Baba is you
  • Back 4 Blood
  • Back 4 blood (EU)
  • Backbone
  • Banners of Ruin
  • Bartlow's Dread Machine
  • Basement
  • Batbarian: Testament of the Primordials
  • Batman: Arkham Asylum Game of the Year Edition
  • Batman: Arkham Origins
  • Battle Royale Tycoon
  • Battlecruisers
  • Battlestar Galactica Deadlock
  • BATTLESTAR GALACTICA DEADLOCK SEASON ONE
  • Battlestar Galactica Deadlock: Complete
  • BATTLETECH MERCENARY COLLECTION
  • BATTLETECH Shadow Hawk Pack
  • BEAUTIFUL DESOLATION
  • Bee Simulator
  • BEFORE WE LEAVE
  • Beholder 2
  • Ben 10
  • Ben 10: Power Trip
  • Bendy and the Ink Machine™
  • Between the Stars
  • Beyond a Steel Sky
  • Beyond The Edge Of Owlsgard
  • BEYOND THE WIRE
  • Beyond: Two Souls
  • BIOMUTANT
  • Bionic Commando
  • BioShock: The Collection
  • BLACK BOOK
  • Black Moon Chronicles
  • Black Paradox
  • BLACK SKYLANDS
  • BLACKHOLE: Complete Edition
  • Blacksad: Under the Skin
  • Blade of Darkness
  • Blasphemous
  • Blazing Chrome
  • Blightbound
  • Blood And Zombies
  • Blood Rage: Digital Edition
  • Bloodstained: Ritual of the Night
  • Blue Fire
  • Bomber Crew
  • Boneless Zombie
  • Boomerang Fu
  • Borderlands 3
  • Borderlands 3 Super Deluxe
  • Borderlands 3 Super Deluxe Edition
  • Borderlands: The Handsome Collection
  • Bot Vice
  • Bounty of One
  • Brawlout
  • Breakout: Recharged
  • Breathedge
  • bridge constructor
  • Bridge constructor medieval
  • bridge constructor stunts
  • Brigador: Up-Armored Edition
  • Broken Lines
  • Bug Fables: The Everlasting Sapling
  • BUILDER SIMULATOR
  • calico
  • Call of Duty® Modern Warfare 3™ (2011)
  • Call of Juarez: Gunslinger
  • Capitalism 2
  • Car Mechanic 2018
  • Car Mechanic Simulator 2015
  • Car Mechanic Simulator 2018
  • Cardboard Town
  • Castle Morihisa
  • castle storm
  • CastleStorm
  • Cat Cafe Manager
  • Catherine Classic
  • Caveblazers
  • Celeste
  • Centipede: Recharged
  • Cepheus Protocol
  • CHANGE: A Homeless Survival Experience
  • Charlie's Adventure
  • Chasm
  • Chenso Club
  • Chernobylite: Enhanced Edition
  • Chess Ultra
  • Chicago 1930 : The Prohibition
  • Chivalry 2
  • Chorus
  • Chorus
  • Circuit Superstars
  • Cities Skylines + After Dark
  • Cities: Skylines
  • City of Beats
  • CivCity: Rome
  • Click and Slay
  • Cloud Gardens
  • Cloudpunk
  • Code Vein
  • Coffee Talk
  • Comedy Night
  • Command & Conquer Remastered (Origin)
  • Complete Dread X Collection
  • Conarium
  • Construction Simulator (2015) Deluxe Edition
  • Constructor Plus
  • Control
  • Cook, Serve, Delicious! 3
  • Cook, Serve, Delicious! 3?!
  • Cookie Cutter
  • cornucopia
  • Corridor Z
  • Cosmic Osmo and the Worlds Beyond the Mackerel
  • Cosmonautica
  • Crash Drive 2
  • Crash Drive 3
  • Creaks
  • Creepy Tale
  • Crookz the big heist
  • CROSSBOW: Bloodnight
  • Crush Your Enemies
  • Cube Runner
  • Cultist Simulator: Anthology Edition
  • Curse: The Eye of Isis
  • Cyber Ops
  • Cybercube
  • Danger Scavenger
  • Dark Deity
  • Dark Future
  • Darkside Detective
  • Darksiders II Deathinitive Edition
  • Darkwood
  • DARQ: Complete Edition
  • Day of the Tentacle Remastered
  • days of war definitive edition
  • DC League of Super-Pets: The Adventures of Krypto and Ace
  • DC's Justice League: Cosmic Chaos
  • Dead by Daylight
  • Dead Estate
  • Dead Island Definitive Edition
  • Dead Rising 2
  • Deadly Days
  • Dear Esther: Landmark Edition
  • DEATH STRANDING DIRECTOR'S CUT
  • Death's Gambit
  • Deceased
  • DECEIVE INC.
  • Degrees of Separation
  • Deleveled
  • Delicious! Pretty Girls Mahjong Solitaire
  • Deliver Us The Moon
  • Demetrios - Deluxe Edition
  • Depraved
  • DESCENDERS
  • Desert Child
  • DESOLATE
  • Destiny 2: Beyond Light
  • DESTROYER: THE U-BOAT HUNTER
  • Detention
  • Devil May Cry HD Collection
  • Devilated
  • Dicey Dungeons
  • Dirt 5
  • dirt rally
  • Dirt Rally 2.0
  • Disaster Band
  • Disciples III: Reincarnation
  • Disjunction (GOG)
  • DISTRAINT 2
  • Distrust
  • DmC: Devil May Cry
  • Do Not Feed the Monkeys
  • Don't Be Afraid
  • Doomed Lands
  • Door Kickers: Action Squad
  • Doorways: Prelude
  • Downfall
  • Dragons Dogma Dark Arisen
  • Dragon's Dogma: Dark Arisen
  • Drake Hollow
  • Draugen
  • Draw Slasher
  • Drawful 2
  • Dreams in the Witch House
  • Dreamscaper
  • DreamWorks Dragons: Dawn of New Riders
  • DreamWorks Dragons: Legends of the Nine Realms
  • DRIFT21
  • Driftland: The Magic Revival
  • drive!drive!drive!
  • Drone Swarm
  • Due Process
  • Duke Nukem: Manhattan Project
  • Duke of Alpha Centauri
  • Dungeon Rushers
  • Dungeons 2
  • Dungeons 3
  • DUSK
  • Dusk Diver
  • Dust to the End
  • Dynopunk
  • Earth Defense Force 4.1 The Shadow of New Despair
  • Eastern Exorcist
  • Effie
  • Eiyuden Chronicle: Rising
  • El Matador
  • Elderand
  • Elderborn
  • ELDEST SOULS
  • Electrician Simulator
  • Elemental Survivors
  • Elex
  • Elex II
  • Elite Dangerous
  • Embr
  • Empire: Total War - Definitive Edition
  • Empyrion - Galactic Survival
  • ENCASED: A SCI-FI POST-APOCALYPTIC RPG
  • Encodya (GOG)
  • Endless Space 2
  • Endless Space 2 - Digital Deluxe Edition
  • Endless Space® 2 - Digital Deluxe Edition
  • Endzone - A World Apart
  • Epistory - Typing Chronicles
  • Escape the backrooms
  • Eternal Threads
  • Etherborn
  • Europa Universalis IV
  • European Ship Simulator
  • Everdream Valley
  • Evil Genius 2: World Domination
  • EXAPUNKS
  • Exorder
  • EXPEDITIONS: ROME
  • Explosionade
  • F1 2018
  • F1 2019 Anniversary Edition
  • F1 2020
  • F1 RACE STARS Complete Edition Include DLC
  • Fable Anniversary
  • Factory Town
  • Fallback uprising
  • Family Man
  • Family Mysteries 3: Criminal Mindset
  • Fantasy Blacksmith
  • FARMER'S DYNASTY
  • Farming Simulator 17
  • Farming Simulator 19
  • Fast & Furious: Spy Racers Rise of SH1FT3R
  • Fell Seal: Arbiter's Mark
  • Fictorum
  • Field of Glory II
  • Fights in Tight Spaces
  • Figment
  • Filthy Animals Heist Simulator
  • Firefighting Simulator - The Squad
  • Fishing Adventure
  • Flashback
  • FLATLAND Vol.2
  • FlatOut
  • FLING TO THE FINISH
  • Floppy Knights
  • Fluffy Horde
  • FOBIA - ST. DINFNA HOTEL
  • For the King
  • Forged Battalion
  • Forgive me Father
  • Forts
  • Framed Collection
  • Fred3ric
  • Fresh Start Cleaning Simulator
  • Friends vs Friends
  • Frogun
  • From Space
  • From the Depths
  • Frostpunk: Game of the Year Edition
  • Frozenheim
  • Fun with Ragdolls: The Game
  • Funtasia
  • Fury Unleashed
  • Gamedec - Definitive Edition
  • Gang Beasts
  • GARAGE bad trip
  • Garden Story
  • Garfield Kart
  • GAS STATION SIMULATOR
  • Gelly Break Deluxe
  • Genesis Alpha One Deluxe Edition
  • Gevaudan
  • Ghost Song
  • Ghostrunner
  • Giana Sisters 2D
  • GIGA WRECKER
  • Gigantosaurus: Dino Kart
  • Glitch Busters: Stuck On You
  • Gloria Victis
  • Go Home Dinosaurs
  • Goat of Duty
  • Godlike Burger
  • Godstrike
  • Going Under
  • Golf Gang
  • Golf It!
  • Gone Home + Original Soundtrack
  • Good Knight
  • Gotham Knights
  • Graveyard Keeper
  • GREAK: MEMORIES OF AZUR
  • GREEDFALL
  • Gremlins, inc
  • grey goo
  • GRID - 2019
  • grid ultimate
  • GRIP: Combat Racing
  • GRIP: Combat Racing Artifex DLC
  • Gungrave G.O.R.E
  • Guppy
  • Guts and glory
  • GYLT
  • Hacknet
  • HackyZack
  • Haegemonia: Legions of Iron
  • Hamilton's Great Adventure
  • Hammerting
  • Hammerwatch
  • Hands of Necromancy
  • Havsala: Into the Soul Palace
  • Headsnatchers
  • Heartwood Heroes
  • Heat Signature
  • Heaven's Vault
  • Helheim Hassle
  • Hell Let Loose
  • Hellblade: Senua's Sacrifice
  • Hellbound
  • Hellpoint
  • Hellslave
  • Hellstuck: Rage With Your Friends
  • Hero of the Kingdom III
  • Hero of the Kingdom: The Lost Tales 2
  • Heroes of Hammerwatch
  • Heros hour
  • Hexologic
  • Hidden & Dangerous 2: Courage Under Fire
  • Hidden & Dangerous: Action Pack
  • Hidden Deep
  • Hi-Fi Rush
  • High On Life
  • Hitman (2016) Game of the Year Edition
  • HITMAN 2 - Gold Edition
  • Hitman: The Complete First Season
  • Hoa
  • Hob
  • Hollow Knight
  • Holy Potatoes! A Spy Story?!
  • Home Sweet Home
  • Home Sweet Home EP2
  • Homestead Arcana
  • Hood: Outlaws & Legends
  • Hoplegs
  • Hot Tin Roof: The Cat That Wore A Fedora
  • HOT WHEELS UNLEASHED ™
  • Hotel Transylvania 3: Monsters Overboard
  • Hotel Transylvania: Scary-Tale Adventures
  • Hotshot Racing
  • House Flipper
  • How to Survive 2
  • Hue
  • Human: Fall Flat
  • HUMANKIND DEFINITIVE EDITION
  • Hungry Flame
  • Hyper Knights
  • I am Bread
  • I Am Fish
  • I am not a Monster: First Contact
  • I Hate Running Backwards
  • ibb & obb Double Pack
  • ICBM
  • Ice Age Scrat's Nutty Adventure
  • Ice Age: Scrat's Nutty Adventure
  • Ice Lakes
  • Impostor Factory
  • IN SOUND MIND
  • Indivisible
  • INDUSTRIA
  • Infectonator 3: Apocalypse
  • Infinite Beyond The Mind
  • Injustice 2 Legendary Edition
  • Insane 2
  • INSOMNIA: The Ark
  • Internet Cafe Simulator
  • Internet Cafe Simulator 2
  • Interstellar Space: Genesis
  • Iris and the Giant
  • Iron Fisticle
  • Iron Harvest
  • Ittle Dew
  • Ittle Dew 2+
  • Jack Move
  • Jackbox party pack 2
  • Jackbox party pack 5
  • JANITOR BLEEDS
  • Joint Task Force
  • Jotun: Valhalla Edition
  • Journey For Elysium
  • Journey to the Savage Planet
  • JUMANJI: The Video Game
  • Jurassic Park: The Game
  • Jurassic World Evolution
  • Jurassic World Evolution 2
  • JUST CAUSE 4: COMPLETE EDITION
  • Just Die Already
  • Kardboard Kings: Card Shop Simulator
  • Keep Talking and Nobody Explodes
  • Ken Follett's The Pillars of the Earth
  • Kentucky Route Zero - Season Pass Edition
  • Kerbal Space Program
  • Kill it with Fire
  • Killing Floor 2
  • Killing Floor 2 Digital Deluxe Edition
  • Killing Room
  • Kingdom Two Crowns
  • Kingdom: New Lands
  • King's Bounty: Crossworlds
  • Knights of Pen & Paper 2
  • Knock-knock
  • Koi-Koi Japan [Hanafuda playing cards] *Koi-Koi Japan : UKIYOE tours Vol.1 DLC *Koi-Koi Japan : UKIYOE tours Vol.2 DLC *Koi-Koi Japan : UKIYOE tours Vol.3 DLC
  • Konung 2
  • KungFu Kickball
  • Labyrinthine
  • Lair of the Clockwork God
  • Laserlife
  • Last Kids on Earth and the Staff of Doom
  • LAST OASIS
  • Lawn Mowing Simulator
  • Layers of Fear: Masterpiece Edition
  • Lead and Gold: Gangs of the Wild West
  • Learn Japanese To Survive! Hiragana Battle
  • Learn Japanese To Survive! Katakana War
  • Learn Japanese to Survive! Trilogy
  • Legend of Keepers
  • LEGION TD 2 - MULTIPLAYER TOWER DEFENSE
  • LEGION TD 2 - MULTIPLAYER TOWER DEFENSE.
  • Leisure Suit Larry - Wet Dreams Don't Dry
  • Leisure Suit Larry 1-7
  • Lemnis Gate
  • Lemon Cake
  • lethal league blaze
  • Let's School
  • Levelhead
  • Liberated (GOG)
  • Life is Strange Complete Season (Episodes 1-5)
  • Light Fairytale Episode 1
  • Light Fairytale Episode 2
  • LIGHTMATTER
  • Little dragons cafe
  • Little Hope
  • Little Inner Monsters - Card Game
  • Little Misfortune
  • Little Nightmares
  • Little Nightmares Complete Edition
  • Livelock
  • Loop Hero
  • Loot River
  • Looterkings
  • Lornsword Winter Chronicle
  • Lost Castle
  • Love Letter
  • Lovecraft's Untold Stories
  • Lovely planet arcade
  • Lucius 2
  • Lucius 3
  • Ludus
  • Lumberhill
  • LunarLux
  • Lust for Darkness
  • Lust from Beyond: M Edition
  • Mad Experiments: Escape Room
  • Mad Max
  • Mafia Definitive Edition
  • Mafia iii
  • Mafia: Definitive Edition
  • Magenta Horizon
  • Mahjong Pretty Girls Battle
  • Mahjong Pretty Girls Battle : School Girls Edition
  • Maid of Sker
  • Mail Time
  • Maize
  • Maneater
  • Marooners
  • MARSUPILAMI - HOOBADVENTURE
  • Marvel's Avengers - The Definitive Edition
  • Mato Anomalies
  • Max Payne 3
  • Mechs & Mercs: Black Talons
  • Medieval II: Total War - Definitive Edition
  • Medieval: Total War Collection
  • MEEPLE STATION
  • Men of War
  • MERCHANT OF THE SKIES
  • METAL HELLSINGER
  • Metal Hellsinger
  • Metro Exodus
  • Metro last light
  • Metro: Last Light Redux
  • Middle-earth: Shadow of Mordor GOTY
  • Middle-earth: Shadow of Mordor GOTY
  • Middle-Earth: Shadow of War Definitive Edition
  • MIDNIGHT PROTOCOL
  • Mighty Switch Force! Collection
  • Milky Way Prince - The Vampire Star
  • MIND SCANNERS
  • Ministry of Broadcast
  • Minute of Islands
  • Miscreated
  • Mists of Noyah
  • MKXL
  • Mob Factory
  • Mob Rule Classic
  • Monaco
  • Monster Hunter: Rise
  • Monster Slayers - Complete Edition
  • Monstrum
  • Monstrum 2
  • Moon Hunters
  • Moons of Madness
  • MORDHAU
  • Mordheim: City of the Damned
  • Mortal Kombat 11 Ultimate Edition
  • MORTAL KOMBAT XL
  • Mortal Shell
  • Motorcycle Mechanic Simulator 2021
  • Mr. Run and Jump
  • MudRunner
  • Murder Mystery Machine
  • My Big Sister
  • My Friend Peppa Pig
  • My Little Universe
  • My Lovely Wife
  • My Summer Adventure: Memories of Another Life
  • My Time At Portia
  • Mythforce
  • N++ (NPLUSPLUS)
  • Napoleon: Total War - Definitive Edition
  • NARUTO TO BORUTO: SHINOBI STRIKER
  • Necesse
  • NECROMUNDA: HIRED GUN
  • Necronator: Dead Wrong
  • NecroVisioN: Lost Company
  • NecroWorm
  • Neighbours back From Hell
  • Nelly Cootalot: Spoonbeaks Ahoy! HD
  • Neon Space
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submitted by calvin324hk to SteamGameSwap [link] [comments]


2024.06.07 19:20 Temporary_Noise_4014 RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

https://preview.redd.it/ipglk9e9o65d1.png?width=325&format=png&auto=webp&s=ef496929ad531bcef3f1c1d192e4c024bfcaef33
LOS ALTOS, Calif.--(BUSINESS WIRE)--RenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, today provided a letter to shareholders from Chief Executive Officer, Shaun Bagai.
Dear Fellow RenovoRx Shareholders,
The first quarter of 2024 marked a significant period in our company’s evolution, and we have set the stage for significant milestones in the foreseeable future. Our team is steadfast in RenovoRx’s mission to continue on a clinical pathway towards improving patients’ lives by using our patented products to deliver precision therapies that have the potential to transform the standard of care in difficult-to-treat cancers.
With $17.2 million in gross proceeds raised since the beginning of 2024, and with a proven history of prudent stewardship of our capital resources, RenovoRx has sufficient funding to advance our pivotal Phase III TIGeR-PaC clinical trial and expand the development pipeline into additional cancer indications. Our priority remains on TIGeR-PaC in Locally Advanced Pancreatic Cancer (LAPC) first and foremost, and its progress towards a second interim readout triggered by the 52nd event (death) in the trial estimated late 2024, and ultimate completion thereafter. Additionally, we intend to pursue the expansion of our proprietary Trans-Arterial Micro-Perfusion (TAMP™) therapy platform and the clinical development of our pipeline into additional cancer indications. Lastly, we will continue to investigate our ongoing exploration of new commercial business development opportunities with our therapeutic technologies.
During the first quarter, we continued to progress the TIGeR-PaC clinical trial, an ongoing randomized multi-center study in LAPC using RenovoRx’s TAMP therapy platform to evaluate its first product candidate, RenovoGem™, a novel oncology drug-device combination product. The study is comparing treatment with TAMP to the current standard of care (systemic intravenous chemotherapy).
In tandem with the positive progress that we have made in advancing TAMP with our TIGeR-PaC study, we made important additions to our management team and Scientific Advisory Board, bolstering our strong leadership. These additions enhance our already deep expertise resident at RenovoRx.
In March, RenovoRx promoted Leesa Gentry to Chief Clinical Officer and Ronald B. Kocak to Principal Accounting Officer. These promotions reflect our commitment to assembling a dynamic team poised to continue to lead a successful clinical pathway for our proprietary therapy platform. We have streamlined our team, focusing our efforts on strategic initiatives to drive growth and innovation. On behalf of our Board of Directors, I extend our gratitude to Leesa and Ron for their hard work and dedication to date and congratulate them on their well-deserved promotions.
In March, important research studies were published supporting the TAMP therapy platform, including:
  • A publication of pre-clinical studies supporting the efficacy and drug-delivery mechanism potential of TAMP to improve targeted cancer drug treatment delivery was published in the peer-reviewed Journal of Vascular Interventional Radiology. The manuscript was authored by Khashayar Farsad, MD, PhD of the Department of Interventional Radiology at Oregon Health and Science University, and co-authored by Paula M. Novelli, MD, of the University of Pittsburgh Hillman Cancer Center, together with other researchers, including RenovoRx’s Chief Medical Officer, Ramtin Agah, MD. View press release.
  • David Sperling, MD, Associate Professor of Radiology at Columbia University Irving Medical Center in New York, presented a clinical data abstract at the recent 2024 Society of Interventional Radiology Annual Scientific Meeting. The abstract highlighted a sub-study of the TIGeR-PaC clinical trial and featured important data to assist in optimization of TAMP with better risk stratification of patients while improving guidance of TAMP therapy for LAPC treatment. It is important to understand appropriate candidates for TAMP, and managing patients who could be at any risk is paramount to helping underserved patient populations, like those diagnosed with LAPC. This is especially important given the potential of the TAMP therapy platform. View press release.
The first interim analysis in the Phase III clinical trial was completed in March 2023, with the Data Monitoring Committee recommending a continuation of the study. The TIGeR-PaC study is investigating TAMP in LAPC. The study's primary endpoint is a 6-month Overall Survival benefit with secondary endpoints including reduced side effects versus standard of care. We are expecting the clinical events necessary for a second interim analysis should take place by the end of this year, and we are eagerly anticipating the outcome of this analysis.
In closing, I want to extend our appreciation to our clinical sites and patients in our Phase III clinical trial, along with our long-term and newer shareholders. With your support, our team is very well positioned to continue its commitment to improving patients’ lives and lifespans by delivering precision therapies that have the potential to revolutionize the current paradigm of cancer care. Your trust and confidence in RenovoRx have helped us build the remarkable company we have become, and one whose future has never been brighter.
We encourage anyone interested to visit our website, renovorx.com, to learn more, and email us at [renovorx@kcsa.com](mailto:renovorx@kcsa.com) to contact us.
Sincerely, Shaun R. Bagai, CEO RenovoRx, Inc. (NASDAQ: RNXT)
About RenovoRx, Inc.
RenovoRx is a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug delivery platform for high unmet medical need with a goal to improve therapeutic outcomes for cancer patients undergoing treatment. RenovoRx’s patented Trans-Arterial Micro-Perfusion (TAMP™) therapy platform is designed to ensure precise therapeutic delivery to directly target the tumor while potentially minimizing a therapy’s toxicities versus systemic intravenous therapy. RenovoRx’s novel and patented approach to targeted treatment offers the potential for increased safety, tolerance, and improved efficacy. Our Phase III lead product candidate, RenovoGem™, a novel oncology drug-device combination product, is being investigated under a U.S. investigational new drug application that is regulated by the FDA’s 21 CFR 312 pathway. RenovoGem is currently being evaluated for the treatment of locally advanced pancreatic cancer by the Center for Drug Evaluation and Research (the drug division of FDA).
RenovoRx is committed to transforming the lives of patients by delivering innovative solutions to change the current paradigm of cancer care. RenovoGem is currently under investigation for TAMP therapeutic delivery of gemcitabine and has not been approved for commercial sale.
For more information, visit www.renovorx.com. Follow RenovoRx on Facebook, LinkedIn, and Twitter.
submitted by Temporary_Noise_4014 to StonkFeed [link] [comments]


2024.06.07 19:19 Temporary_Noise_4014 RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

https://preview.redd.it/hqh65yz7o65d1.png?width=325&format=png&auto=webp&s=4f057b0384d87ccaa071d84c10ffff85b0299ae2
LOS ALTOS, Calif.--(BUSINESS WIRE)--RenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, today provided a letter to shareholders from Chief Executive Officer, Shaun Bagai.
Dear Fellow RenovoRx Shareholders,
The first quarter of 2024 marked a significant period in our company’s evolution, and we have set the stage for significant milestones in the foreseeable future. Our team is steadfast in RenovoRx’s mission to continue on a clinical pathway towards improving patients’ lives by using our patented products to deliver precision therapies that have the potential to transform the standard of care in difficult-to-treat cancers.
With $17.2 million in gross proceeds raised since the beginning of 2024, and with a proven history of prudent stewardship of our capital resources, RenovoRx has sufficient funding to advance our pivotal Phase III TIGeR-PaC clinical trial and expand the development pipeline into additional cancer indications. Our priority remains on TIGeR-PaC in Locally Advanced Pancreatic Cancer (LAPC) first and foremost, and its progress towards a second interim readout triggered by the 52nd event (death) in the trial estimated late 2024, and ultimate completion thereafter. Additionally, we intend to pursue the expansion of our proprietary Trans-Arterial Micro-Perfusion (TAMP™) therapy platform and the clinical development of our pipeline into additional cancer indications. Lastly, we will continue to investigate our ongoing exploration of new commercial business development opportunities with our therapeutic technologies.
During the first quarter, we continued to progress the TIGeR-PaC clinical trial, an ongoing randomized multi-center study in LAPC using RenovoRx’s TAMP therapy platform to evaluate its first product candidate, RenovoGem™, a novel oncology drug-device combination product. The study is comparing treatment with TAMP to the current standard of care (systemic intravenous chemotherapy).
In tandem with the positive progress that we have made in advancing TAMP with our TIGeR-PaC study, we made important additions to our management team and Scientific Advisory Board, bolstering our strong leadership. These additions enhance our already deep expertise resident at RenovoRx.
In March, RenovoRx promoted Leesa Gentry to Chief Clinical Officer and Ronald B. Kocak to Principal Accounting Officer. These promotions reflect our commitment to assembling a dynamic team poised to continue to lead a successful clinical pathway for our proprietary therapy platform. We have streamlined our team, focusing our efforts on strategic initiatives to drive growth and innovation. On behalf of our Board of Directors, I extend our gratitude to Leesa and Ron for their hard work and dedication to date and congratulate them on their well-deserved promotions.
In March, important research studies were published supporting the TAMP therapy platform, including:
  • A publication of pre-clinical studies supporting the efficacy and drug-delivery mechanism potential of TAMP to improve targeted cancer drug treatment delivery was published in the peer-reviewed Journal of Vascular Interventional Radiology. The manuscript was authored by Khashayar Farsad, MD, PhD of the Department of Interventional Radiology at Oregon Health and Science University, and co-authored by Paula M. Novelli, MD, of the University of Pittsburgh Hillman Cancer Center, together with other researchers, including RenovoRx’s Chief Medical Officer, Ramtin Agah, MD. View press release.
  • David Sperling, MD, Associate Professor of Radiology at Columbia University Irving Medical Center in New York, presented a clinical data abstract at the recent 2024 Society of Interventional Radiology Annual Scientific Meeting. The abstract highlighted a sub-study of the TIGeR-PaC clinical trial and featured important data to assist in optimization of TAMP with better risk stratification of patients while improving guidance of TAMP therapy for LAPC treatment. It is important to understand appropriate candidates for TAMP, and managing patients who could be at any risk is paramount to helping underserved patient populations, like those diagnosed with LAPC. This is especially important given the potential of the TAMP therapy platform. View press release.
The first interim analysis in the Phase III clinical trial was completed in March 2023, with the Data Monitoring Committee recommending a continuation of the study. The TIGeR-PaC study is investigating TAMP in LAPC. The study's primary endpoint is a 6-month Overall Survival benefit with secondary endpoints including reduced side effects versus standard of care. We are expecting the clinical events necessary for a second interim analysis should take place by the end of this year, and we are eagerly anticipating the outcome of this analysis.
In closing, I want to extend our appreciation to our clinical sites and patients in our Phase III clinical trial, along with our long-term and newer shareholders. With your support, our team is very well positioned to continue its commitment to improving patients’ lives and lifespans by delivering precision therapies that have the potential to revolutionize the current paradigm of cancer care. Your trust and confidence in RenovoRx have helped us build the remarkable company we have become, and one whose future has never been brighter.
We encourage anyone interested to visit our website, renovorx.com, to learn more, and email us at [renovorx@kcsa.com](mailto:renovorx@kcsa.com) to contact us.
Sincerely, Shaun R. Bagai, CEO RenovoRx, Inc. (NASDAQ: RNXT)
About RenovoRx, Inc.
RenovoRx is a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug delivery platform for high unmet medical need with a goal to improve therapeutic outcomes for cancer patients undergoing treatment. RenovoRx’s patented Trans-Arterial Micro-Perfusion (TAMP™) therapy platform is designed to ensure precise therapeutic delivery to directly target the tumor while potentially minimizing a therapy’s toxicities versus systemic intravenous therapy. RenovoRx’s novel and patented approach to targeted treatment offers the potential for increased safety, tolerance, and improved efficacy. Our Phase III lead product candidate, RenovoGem™, a novel oncology drug-device combination product, is being investigated under a U.S. investigational new drug application that is regulated by the FDA’s 21 CFR 312 pathway. RenovoGem is currently being evaluated for the treatment of locally advanced pancreatic cancer by the Center for Drug Evaluation and Research (the drug division of FDA).
RenovoRx is committed to transforming the lives of patients by delivering innovative solutions to change the current paradigm of cancer care. RenovoGem is currently under investigation for TAMP therapeutic delivery of gemcitabine and has not been approved for commercial sale.
For more information, visit www.renovorx.com. Follow RenovoRx on Facebook, LinkedIn, and Twitter.
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2024.06.07 19:19 Temporary_Noise_4014 RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

LOS ALTOS, Calif.--(BUSINESS WIRE)--RenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, today provided a letter to shareholders from Chief Executive Officer, Shaun Bagai. Dear Fellow RenovoRx Shareholders, The first quarter of 2024 marked a significant period in our company’s evolution, and we have set the stage for significant milestones in the foreseeable future. Our team is steadfast in RenovoRx’s mission to continue on a clinical pathway towards improving patients’ lives by using our patented products to deliver precision therapies that have the potential to transform the standard of care in difficult-to-treat cancers. With $17.2 million in gross proceeds raised since the beginning of 2024, and with a proven history of prudent stewardship of our capital resources, RenovoRx has sufficient funding to advance our pivotal Phase III TIGeR-PaC clinical trial and expand the development pipeline into additional cancer indications. Our priority remains on TIGeR-PaC in Locally Advanced Pancreatic Cancer (LAPC) first and foremost, and its progress towards a second interim readout triggered by the 52nd event (death) in the trial estimated late 2024, and ultimate completion thereafter. Additionally, we intend to pursue the expansion of our proprietary Trans-Arterial Micro-Perfusion (TAMP™) therapy platform and the clinical development of our pipeline into additional cancer indications. Lastly, we will continue to investigate our ongoing exploration of new commercial business development opportunities with our therapeutic technologies. During the first quarter, we continued to progress the TIGeR-PaC clinical trial, an ongoing randomized multi-center study in LAPC using RenovoRx’s TAMP therapy platform to evaluate its first product candidate, RenovoGem™, a novel oncology drug-device combination product. The study is comparing treatment with TAMP to the current standard of care (systemic intravenous chemotherapy). In tandem with the positive progress that we have made in advancing TAMP with our TIGeR-PaC study, we made important additions to our management team and Scientific Advisory Board, bolstering our strong leadership. These additions enhance our already deep expertise resident at RenovoRx. In March, RenovoRx promoted Leesa Gentry to Chief Clinical Officer and Ronald B. Kocak to Principal Accounting Officer. These promotions reflect our commitment to assembling a dynamic team poised to continue to lead a successful clinical pathway for our proprietary therapy platform. We have streamlined our team, focusing our efforts on strategic initiatives to drive growth and innovation. On behalf of our Board of Directors, I extend our gratitude to Leesa and Ron for their hard work and dedication to date and congratulate them on their well-deserved promotions. In March, important research studies were published supporting the TAMP therapy platform, including: A publication of pre-clinical studies supporting the efficacy and drug-delivery mechanism potential of TAMP to improve targeted cancer drug treatment delivery was published in the peer-reviewed Journal of Vascular Interventional Radiology. The manuscript was authored by Khashayar Farsad, MD, PhD of the Department of Interventional Radiology at Oregon Health and Science University, and co-authored by Paula M. Novelli, MD, of the University of Pittsburgh Hillman Cancer Center, together with other researchers, including RenovoRx’s Chief Medical Officer, Ramtin Agah, MD. View press release. David Sperling, MD, Associate Professor of Radiology at Columbia University Irving Medical Center in New York, presented a clinical data abstract at the recent 2024 Society of Interventional Radiology Annual Scientific Meeting. The abstract highlighted a sub-study of the TIGeR-PaC clinical trial and featured important data to assist in optimization of TAMP with better risk stratification of patients while improving guidance of TAMP therapy for LAPC treatment. It is important to understand appropriate candidates for TAMP, and managing patients who could be at any risk is paramount to helping underserved patient populations, like those diagnosed with LAPC. This is especially important given the potential of the TAMP therapy platform. View press release. The first interim analysis in the Phase III clinical trial was completed in March 2023, with the Data Monitoring Committee recommending a continuation of the study. The TIGeR-PaC study is investigating TAMP in LAPC. The study's primary endpoint is a 6-month Overall Survival benefit with secondary endpoints including reduced side effects versus standard of care. We are expecting the clinical events necessary for a second interim analysis should take place by the end of this year, and we are eagerly anticipating the outcome of this analysis. In closing, I want to extend our appreciation to our clinical sites and patients in our Phase III clinical trial, along with our long-term and newer shareholders. With your support, our team is very well positioned to continue its commitment to improving patients’ lives and lifespans by delivering precision therapies that have the potential to revolutionize the current paradigm of cancer care. Your trust and confidence in RenovoRx have helped us build the remarkable company we have become, and one whose future has never been brighter. We encourage anyone interested to visit our website, renovorx.com, to learn more, and email us at renovorx@kcsa.com to contact us. Sincerely, Shaun R. Bagai, CEO RenovoRx, Inc. (NASDAQ: RNXT) About RenovoRx, Inc. RenovoRx is a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug delivery platform for high unmet medical need with a goal to improve therapeutic outcomes for cancer patients undergoing treatment. RenovoRx’s patented Trans-Arterial Micro-Perfusion (TAMP™) therapy platform is designed to ensure precise therapeutic delivery to directly target the tumor while potentially minimizing a therapy’s toxicities versus systemic intravenous therapy. RenovoRx’s novel and patented approach to targeted treatment offers the potential for increased safety, tolerance, and improved efficacy. Our Phase III lead product candidate, RenovoGem™, a novel oncology drug-device combination product, is being investigated under a U.S. investigational new drug application that is regulated by the FDA’s 21 CFR 312 pathway. RenovoGem is currently being evaluated for the treatment of locally advanced pancreatic cancer by the Center for Drug Evaluation and Research (the drug division of FDA). RenovoRx is committed to transforming the lives of patients by delivering innovative solutions to change the current paradigm of cancer care. RenovoGem is currently under investigation for TAMP therapeutic delivery of gemcitabine and has not been approved for commercial sale. For more information, visit www.renovorx.com. Follow RenovoRx on Facebook, LinkedIn, and Twitter.
submitted by Temporary_Noise_4014 to Penny_Stocks [link] [comments]


2024.06.07 19:19 Temporary_Noise_4014 RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

RenovoRx CEO Issues Update Letter to Shareholders (NASDAQ: RNXT)

https://preview.redd.it/t3fxd7x4o65d1.png?width=325&format=png&auto=webp&s=44b4e25004d012024d73aca01acadf167fdc02e6
LOS ALTOS, Calif.--(BUSINESS WIRE)--RenovoRx, Inc. (“RenovoRx” or the “Company”) (Nasdaq: RNXT), a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug-delivery platform, today provided a letter to shareholders from Chief Executive Officer, Shaun Bagai.
Dear Fellow RenovoRx Shareholders,
The first quarter of 2024 marked a significant period in our company’s evolution, and we have set the stage for significant milestones in the foreseeable future. Our team is steadfast in RenovoRx’s mission to continue on a clinical pathway towards improving patients’ lives by using our patented products to deliver precision therapies that have the potential to transform the standard of care in difficult-to-treat cancers.
With $17.2 million in gross proceeds raised since the beginning of 2024, and with a proven history of prudent stewardship of our capital resources, RenovoRx has sufficient funding to advance our pivotal Phase III TIGeR-PaC clinical trial and expand the development pipeline into additional cancer indications. Our priority remains on TIGeR-PaC in Locally Advanced Pancreatic Cancer (LAPC) first and foremost, and its progress towards a second interim readout triggered by the 52nd event (death) in the trial estimated late 2024, and ultimate completion thereafter. Additionally, we intend to pursue the expansion of our proprietary Trans-Arterial Micro-Perfusion (TAMP™) therapy platform and the clinical development of our pipeline into additional cancer indications. Lastly, we will continue to investigate our ongoing exploration of new commercial business development opportunities with our therapeutic technologies.
During the first quarter, we continued to progress the TIGeR-PaC clinical trial, an ongoing randomized multi-center study in LAPC using RenovoRx’s TAMP therapy platform to evaluate its first product candidate, RenovoGem™, a novel oncology drug-device combination product. The study is comparing treatment with TAMP to the current standard of care (systemic intravenous chemotherapy).
In tandem with the positive progress that we have made in advancing TAMP with our TIGeR-PaC study, we made important additions to our management team and Scientific Advisory Board, bolstering our strong leadership. These additions enhance our already deep expertise resident at RenovoRx.
In March, RenovoRx promoted Leesa Gentry to Chief Clinical Officer and Ronald B. Kocak to Principal Accounting Officer. These promotions reflect our commitment to assembling a dynamic team poised to continue to lead a successful clinical pathway for our proprietary therapy platform. We have streamlined our team, focusing our efforts on strategic initiatives to drive growth and innovation. On behalf of our Board of Directors, I extend our gratitude to Leesa and Ron for their hard work and dedication to date and congratulate them on their well-deserved promotions.
In March, important research studies were published supporting the TAMP therapy platform, including:
  • A publication of pre-clinical studies supporting the efficacy and drug-delivery mechanism potential of TAMP to improve targeted cancer drug treatment delivery was published in the peer-reviewed Journal of Vascular Interventional Radiology. The manuscript was authored by Khashayar Farsad, MD, PhD of the Department of Interventional Radiology at Oregon Health and Science University, and co-authored by Paula M. Novelli, MD, of the University of Pittsburgh Hillman Cancer Center, together with other researchers, including RenovoRx’s Chief Medical Officer, Ramtin Agah, MD. View press release.
  • David Sperling, MD, Associate Professor of Radiology at Columbia University Irving Medical Center in New York, presented a clinical data abstract at the recent 2024 Society of Interventional Radiology Annual Scientific Meeting. The abstract highlighted a sub-study of the TIGeR-PaC clinical trial and featured important data to assist in optimization of TAMP with better risk stratification of patients while improving guidance of TAMP therapy for LAPC treatment. It is important to understand appropriate candidates for TAMP, and managing patients who could be at any risk is paramount to helping underserved patient populations, like those diagnosed with LAPC. This is especially important given the potential of the TAMP therapy platform. View press release.
The first interim analysis in the Phase III clinical trial was completed in March 2023, with the Data Monitoring Committee recommending a continuation of the study. The TIGeR-PaC study is investigating TAMP in LAPC. The study's primary endpoint is a 6-month Overall Survival benefit with secondary endpoints including reduced side effects versus standard of care. We are expecting the clinical events necessary for a second interim analysis should take place by the end of this year, and we are eagerly anticipating the outcome of this analysis.
In closing, I want to extend our appreciation to our clinical sites and patients in our Phase III clinical trial, along with our long-term and newer shareholders. With your support, our team is very well positioned to continue its commitment to improving patients’ lives and lifespans by delivering precision therapies that have the potential to revolutionize the current paradigm of cancer care. Your trust and confidence in RenovoRx have helped us build the remarkable company we have become, and one whose future has never been brighter.
We encourage anyone interested to visit our website, renovorx.com, to learn more, and email us at [renovorx@kcsa.com](mailto:renovorx@kcsa.com) to contact us.
Sincerely, Shaun R. Bagai, CEO RenovoRx, Inc. (NASDAQ: RNXT)
About RenovoRx, Inc.
RenovoRx is a clinical-stage biopharmaceutical company developing novel precision oncology therapies based on a local drug delivery platform for high unmet medical need with a goal to improve therapeutic outcomes for cancer patients undergoing treatment. RenovoRx’s patented Trans-Arterial Micro-Perfusion (TAMP™) therapy platform is designed to ensure precise therapeutic delivery to directly target the tumor while potentially minimizing a therapy’s toxicities versus systemic intravenous therapy. RenovoRx’s novel and patented approach to targeted treatment offers the potential for increased safety, tolerance, and improved efficacy. Our Phase III lead product candidate, RenovoGem™, a novel oncology drug-device combination product, is being investigated under a U.S. investigational new drug application that is regulated by the FDA’s 21 CFR 312 pathway. RenovoGem is currently being evaluated for the treatment of locally advanced pancreatic cancer by the Center for Drug Evaluation and Research (the drug division of FDA).
RenovoRx is committed to transforming the lives of patients by delivering innovative solutions to change the current paradigm of cancer care. RenovoGem is currently under investigation for TAMP therapeutic delivery of gemcitabine and has not been approved for commercial sale.
For more information, visit www.renovorx.com. Follow RenovoRx on Facebook, LinkedIn, and Twitter.
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2024.06.07 19:19 abhikavi Has anyone hacked a CamelBak or similar drinking system into a half-face respirator?

I love my GVS Eclipse, but often end up wearing an Aura with a sip valve instead for longer-term use, because I need to stay hydrated, and I'm trying to balance the risk of the less-solid protection of an N95 versus the risk of having to lift my entire mask to drink while wearing my half-face.
I'm eying the Dentec Comfort-Air and the MSA Advantage as masks that look like they get good reviews and would have the space to add in a sip valve, and I'm thinking about drilling a hole, inserting a CamelBak (or similar) hands-free drinking system, and sealing the joint with silicon caulk.
Has anyone done anything like this before? I was looking to find examples/tutorials/etc, but most of what I'm seeing is drinking systems for CBRN setups.
(As a general rule of thumb, modifying any PPE is not a good thing to do. I'm considering it here because the realistic alternative is lifting my mask to drink, and that's an objectively terrible baseline. Being able to improve on that at all would be huge.)
submitted by abhikavi to Masks4All [link] [comments]


2024.06.07 18:24 Firefox72 In China Furiosa opens with just $1.1M. Aiming for a $3.5-$4.5M 4 Day weekend. Civil War opens with $0.38M/$1.66M. Garfield in 5th adds $0.64M/$10.45M. Will be pushing for $15M+ through Monday. Walk The Line and Be My Friend will go head to head tommorow both aiming for a $7-8M opening day.

In China Furiosa opens with just $1.1M. Aiming for a $3.5-$4.5M 4 Day weekend. Civil War opens with $0.38M/$1.66M. Garfield in 5th adds $0.64M/$10.45M. Will be pushing for $15M+ through Monday. Walk The Line and Be My Friend will go head to head tommorow both aiming for a $7-8M opening day.
https://preview.redd.it/wap495d8e65d1.png?width=613&format=png&auto=webp&s=c0836d1f3e68f7d63b8ae23f495bf5bfa7b82a58

Daily Box Office (June 7th 2024)

The market hits ¥48.1M/$6.6M which is up +81% versus yesterday and down -1% versus last week.
Furiosa opens barelly above $1M. Tomorrow with the onslaught of Dragon Boat Festival Local releases it will already lose 72% of its screenings. Its projecte to drop below Garfield.
Civil War does even worse opening with just $0.38M which alongside its pre-screenings from last week means a $1.66M total so far.
Province map of the day:
https://imgsli.com/MjcwNTcz
Furiosa strugles to get a grip of the market on its opening day being very much so challenged by Be My Friends pre-screenings.
In Metropolitan cities:
Garfield wins Shanghai, Wuhan, Hangzhou
Crisis Negotiators wins Guangzhou
The Last Frenzy wins Beijing, Chengdu, Suzhou and Chongqing
Twilight of the Warriors wins Shenzhen and Nanjing
City tiers:
Garfield jumps Twilight of the Warriors in T2-T4.
Tier 1: Twilight of the Warriors>Crisis Negotiators>The Last Frenzy
Tier 2: The Last Frenzy>Garfield>Twilight of the Warriors
Tier 3: The Last Frenzy>Garfield>Twilight of the Warriors
Tier 4: The Last Frenzy>Garfield>Twilight of the Warriors
# Movie Gross %YD %LW Screenings Admisions(Today) Total Gross Projected Total Gross
1 Furiosa: A Mad Max Saga $1.10M 54541 0.18M $1.10M $6M-$7M
2 Be My Friend(Pre-Scr) $0.98M +180% 42295 0.18M $4.15M $54M-$56M
3 Walk The Line(Pre-Scr) $0.91M +160% 43591 0.17M $5.16M $47M-$51M
4 Crisis Negotiators(Pre-Scr) $0.65M +97% 20807 0.12M $5.63M $25M-$36M
5 Garfield $0.64M +34% 35943 0.13M $10.45M $19M-$22M
6 The Last Frenzy $0.47M -26% -51% 37706 0.09M $106.67M $6M-$111M
7 Civil War $0.38M 17890 0.07M $1.66M $5M-$7M
8 Twilight of the Warriors $0.31M -34% -61% 25610 0.05M $90.10M $94M-$95M
9 Doraemon: Nobita's Earth Symphony $0.27M +13% -85% 29998 0.05M $13.68M $19M-$28M
*YD=Yesterday, LW=Last Week,
Pre-Sales map for tomorrow
The new releases tomorrow lead the pre-sales across the country.
https://i.imgur.com/fkXqCDB.png

Garfield

Garfield with continues to string together good days. It will now try to push to $15M+ through Monday.
Audience Figures:
WoM figures: Maoyan: 9.2 , Taopiaopiao: 9.6 , Douban: 7.0
A small sample size of 6k ratings but so far the movie appears to be received positively with very high 9.5-9.6 rating average on Taopiaopiao. Women make up a majority of the viewers with a 63-37% split.
Surprisingly enough the 30-40 age groups have the highest % of viewers likely fueled by parents of kids leaving reviews. People over 40 have rated the movie the best with a high 9.8 ratings average.
# SAT SUN MON TUE WED THU FRI Total
First Week $5.92M $2.26M $0.40M $0.36M $0.39M $0.48M $0.64M $10.45M
Scheduled showings update for Garfield for the next few days:
Day Number of Showings Presales Projection
Today 35135 $112k $0.63M-$0.68M
Saturday 21864 $310k $1.43M-$1.90M
Sunday 26096 $65k $1.51M-$2.10M
Monday 11835 $11k $1.19M-$1.89M

Other stuff:

The next holywood releases currently scheduled are IF on June 15th, Inside Out 2 on June 21st, Bad Boys 4 on June 22nd and Despicable Me 4 on July 12th
Haikyu!! The Movie: Decisive Battle at the Garbage Dump will release on the 15th June.
Moments We Shared will kick off the local summer season on June 22nd.

Dragon Boat Festival(June 10th)

Dragon Boat Festival lands on a Monday this year so its a single day holiday linked to the weekend instead of a 3 day period.
Its early June date this year which is a bit too soon for the summer season that starts at the end of the month means there's not really anything heavy hitting schedule for it but there will be a barage of small to mid sized local movies hitting alongside 2 Holywood movies in Civil War and Furiosa.
Very uninspiring last day for pretty much all 4 movies releasing tomorrow.
Days till release Walk The Line Be My Friend Crisis Negotiators Gold or Shit Furiosa Civil War
7 $208k/34706 $175k/26676 $123k/27514 $177k/17158 / $14k/7398
6 $225k/35101 $200k/27323 $138k/27619 $202k/17948 / $15k/7561
5 $251k/35507 $230k/28059 $156k/27725 $238k/19097 / $18k/7592
4 $290k/37032 $282k/30477 $173k/28524 $275k/22662 / $24k/7543
3 $337k/42162 $332k/37189 $198k/32060 $328k/29949 $7k/9885 $33k/7962
2 $400k/62878 $402k/58067 $223k/45966 $377k/49794 $26k/20756 $44k/10094
1 $529k/86106 $518k/81507 $268k/61986 $484k/70359 $64k/40846 $61k/14973
0 $810k/101026 $830k/96774 $445k/73823 $679k/83298 $162k/55039 $100k/18499
Opening Day $7.0M-$8.0M $6.7M-$7.9M $3.8M-$4.8M $4.3M-$4.5M $1.0M-$1.0M $0.6M-$0.7M
Total Projections $40-41M $27-44M $16-29M $11-22M $5-11M $5-8M
*Gross/Screenings

Haikyu!! The Movie: Decisive Battle at the Garbage Dump

Another good day. Tomorrow it will surpass $1M in pre-sales a week ahead of its release day.
Days till release Haikyu!! The Movie The Boy and The Heron Suzume Weathering with You Spirited Away Spy X Family
10 $63k/3807 $43k/1681 / / $34k/6305 $261k/28448
9 $422k/24796 $100k/3218 / / $61k/10503 $348k/31114
8 $754k/40094 $280k/13912 $161k/10580 / $80k/12835 $462k/33040
7 $981k/47072 $544k/19922 $1.02M/40753 $10k/1084 $105k/14762 $570k/36613
6 $814k/23251 $1.73M/56880 $134k/10888 $149k/18082 $689k/39929
5 $1.14M/26071 $2.22M/65278 $276k/15047 $204k/20762 $826k/43490
4 $1.61M/28985 $3.07M/72768 $472k/19411 $289k/23684 $952k/47610
3 $2.02M/31970 $4.36M/89752 $752k/27974 423k/31262 $1.10M/53982
2 $2.64M/35560 $5.14M/111454 $1.16M/38988 $753k/48242 $1.31M/60770
1 $4.09M/27343 $5.87M/135991 $1.73M/58456 1.19M/70921 $1.57M/75112
0 $6.86M/62802 $8.61M/155499 $3.07M/82049 $2.33M/97267 $2.34M/8796
Opening Day $14.0M $13.7M $6.6M $7.9M $4.9M
*Gross/Screenings

Release Schedule:

A table including upcoming movies in the next month alongside trailers linked in the name of the movie, Want To See data from both Maoyan and Taopiaopiao alongside the Gender split and genre.
Remember Want To See is not pre-sales. Its just an anticipation metric. A checkbox of sorts saying your interested in an upcoming movie.
Not all movies are included since a lot are just too small to be worth covering.
Dragon Boat Festival(June 10th):
The Dragon Boat Festival lands on a Monday this year which means its gonna be a single day holiday linked to the weekend.
Movie Maoyan WTS Daily Increase Taopiaopiao WTS Daily Increase M/W % Genre Release Date
Walk The Line 154k +2k 75k +1k 34/66 Comedy/Crime 08.06
Gold or Shit 40k +2k 103k +6k 51/49 Comedy/Family 08.06
Be My Friend 109k +3k 24k +1k 31/69 Drama/Comedy 08.06
Crisis Negotiators 28k +1k 20k +457 35/65 Drama 08.06
June:
A few other noteworthy releases in June.
Movie Maoyan WTS Daily Increase Taopiaopiao WTS Daily Increase M/W % Genre Release Date
Haikyu!! The Movie: Decisive Battle at the Garbage Dump 293k +5k 181k +4k 36/64 Animation 15.06
IF 4k +256 4k +327 38/62 Comedy/Fantasy 15.06
Inside Out 2 90k +3k 62k +3k 28/72 Animation 21.06
Reversed Destiny 92k +2k 113k +784 30/70 Romance 21.06
Bad Boys 4 7k +2k 6k +2k 65/35 Action 22.06
Moments We Shared 433k +6k 223k +3k 38/62 Drama/Romance 22.06
A Quiet Place: Day One 14k +2k 7k +1k 40/60 ThrilleHorror 28.06
submitted by Firefox72 to boxoffice [link] [comments]


2024.06.07 18:13 chill_lab Moms of preschoolers who are native speakers of American English: please join a paid research study on maternal communication (moderator-approved post)

Maternal Communication Study

Language, Development, and Cognition Lab (University of Colorado Boulder)
To be taken to our lab website, please click here.
Who Can Participate
Mothers of children between the ages of 3-5 years who are acquiring English as a first language.
What Happens
Mothers will be shown simple animated actions on a screen (e.g., putting an object on a table) and asked to instruct a hypothetical child or adult listener to perform those actions using props.
What We’re Studying
When communicating with our interlocutors, we adapt our speech in different ways to get our message across successfully. Our study investigates how mothers communicate information that is easy versus difficult for child and adult listeners to comprehend.
Duration
The study is conducted via a single Zoom session (scheduled at a time that is convenient for you). The session typically lasts 40-45 minutes or less, depending on the number of breaks.
Compensation
We will email a $20 Amazon gift card to you within 1-2 weeks of completion of the study. We will email you a $5 gift card even if you complete only part of the study.
Interested?
Please fill out our brief questionnaire to sign up for the study.
Contact us at this email with any questions: [ldclab.boulder@colorado.edu](mailto:ldclab.boulder@colorado.edu)
[Moderators: thanks for allowing us to post this message!]
submitted by chill_lab to beyondthebump [link] [comments]


2024.06.07 17:05 giwook A note of caution regarding Seresto collars

I was looking into tick protection for my dog and noticed that one of the most popular recommendations was the Seresto collars, usually on its own but occasionally in combination with topical/oral treatments.
Just as I was about to place an order for a Seresto collar, I found this notice issued just a few months ago (Feb 2024) that highlights a lot of potential issues with the Seresto collar. Here's the link: https://biologicaldiversity.org/w/news/press-releases/federal-watchdog-blasts-epas-failure-to-assess-safety-of-pesticides-used-on-flea-tick-collars-2024-02-29
I'm sure it works well and it's up to you to determine what makes the most sense in regards to your pet (and weighing the trade-offs of using what might be a less effective tick prevention method versus the potential harmful side effects of the collar), but I figured I'd share this so that you can ultimately make the decision for yourself and your furry friend.
Here are the highlights of the article:
Following more than 100,000 reports of Seresto’s harm to pets — including more than 3,000 deaths — the EPA announced in July 2023 that it would limit approval of the product to five years and require more detailed reporting of harm incidents from the flea collar’s maker, Elanco.
Among the report’s findings:
  • The EPA continues to rely on incomplete or outdated studies to keep the pet collars on the market;
  • The agency did not conduct a necessary risk assessment for use of the Seresto pet collar on domestic pets;
  • The EPA lacks proper standards for determining whether pesticides used on pets pose serious risks to people or pets;
  • The EPA’s incident reporting system lacks adequate information to assess the harms from pesticide exposure.
In 2021 the Center for Biological Diversity filed a formal legal petition urging the EPA to cancel the Seresto collar’s registration.
Today’s report comes just weeks after a judge granted preliminary approval to a $15 million settlement of a class action lawsuit filed by pet owners against the makers of Seresto collars.
submitted by giwook to BackpackingDogs [link] [comments]


2024.06.07 15:47 PipPip-OiOi Pick a Song for Each Character (Day 10: Shane)

Pick a Song for Each Character (Day 10: Shane)
Lovers of the classical arts, I see! Behold my new sleep/study playlist. Absolutely poetic and fitting. The overall winner is Nocturne No. 2 in E-Flat Major by Frédéric Chopin! As always, you can find the full Spotify playlist by following the link here: https://open.spotify.com/playlist/6cPlFd9xGAcCO5DEWQjSoA?si=WTEUdQbaQBOG8Gn2QhN-hQ&pi=u-LLPhToF5QmGd
Also of course, don’t forget to support the original artist by looking into Talkohlooey’s portrait mod which can be found here: https://www.nexusmods.com/stardewvalley/mods/5269
Now we’ve reach many of my friends’ Stardew Bachelor of Choice in Shane. I’m curious on the balance of drinking songs versus mental health development songs we get this time around. Exciting! Suggest songs you think best reflect the character, remind you of the character in some way, or is a song you believe he’d listen to on his own!
Remember to be kind, be creative, and be having fun!
submitted by PipPip-OiOi to StardewValley [link] [comments]


2024.06.07 15:20 Read_an_ice_age_saga Dreamer Books: An Ice Age Saga now available in eBook format, too!

Dreamer Books: An Ice Age Saga now available in eBook format, too!
Dreamer Books: An Ice Age Saga is a chronicle from the distant past, when the European continent was yet untamed, and humans fought to endure within a savage environment. Available in hardcover and paperback through most major and independent retailers, now also in eBook format, too! https://dreamerliteraryproductions.com/ebooks/

DreamerBooksAnIceAgeSaga #EAMeigs #Neanderthal #Adventure #PrehistoricFiction #BookSeries #PaleoFiction

https://preview.redd.it/t5hfuqbdh55d1.jpg?width=1700&format=pjpg&auto=webp&s=621c7e2b68a3774c5d9b649c64fd770df6adfc93
submitted by Read_an_ice_age_saga to u/Read_an_ice_age_saga [link] [comments]


http://rodzice.org/