Food stamps ga eligibility caculater
Venerable Minh Tue and the Practice from a Buddhist Perspective
2024.05.19 06:25 Dry-Illustrator5292 Venerable Minh Tue and the Practice from a Buddhist Perspective
A few years ago, I had the chance to learn about Venerable Minh Tue through the YouTube channel Nhan Ga Vlogs. The videos show the monk in a cave at Mount San (Nha Trang), near my home. In these videos, the Venerable does not preach or talk about himself. He only answers questions and shares his journey of practice honestly. What I am most interested in are his insights on practice and discipline. I realized that Venerable Minh Tue has read extensively and understands the Nikaya scriptures deeply, practicing according to the Buddha's teachings. This led me to conclude that he is a true monk.
Today, Venerable Minh Tue is known by many (I prefer not to use the word "famous" for a monastic) and has widespread influence, reaching beyond national borders. The story of Venerable Minh Tue has become hotter than ever, flooding social media with videos and images of him. This has sparked a variety of opinions, ranging from admiration and respect to criticism and contempt. Many paths of human experience!
Fortunately, those who think negatively about him are still a minority.
Venerable Minh Tue practices the ascetic path of Dhutanga. Some people look at his conduct and attire and criticize him as crazy, self-mortifying, lacking wisdom, and not following the Middle Way that the Buddha encouraged. However, these critics do not realize that Venerable Minh Tue is practicing according to the correct Dharma, following the teachings of the original scriptures. He has abandoned family life, living a pure and simple life, renouncing all attachments, and practicing minimalism and contentment. People confuse the ascetic practices of Dhutanga with the severe austerities the Buddha practiced during his six years of seeking enlightenment. Those severe practices involved extreme self-mortification, causing great physical pain (originating from Brahmanism). Thus, Dhutanga in a sense is a precursor to the Middle Way and still closely aligns with it.
Many argue that monastic life should prioritize wisdom over physical asceticism. However, they confuse worldly wisdom with Buddhist wisdom. Worldly wisdom is human cognitive ability, derived from genetics and education, whereas Buddhist wisdom is only revealed when a practitioner strictly adheres to precepts. Observance of precepts leads to concentration, and concentration leads to wisdom. Therefore, the Buddha said, "Where there is virtue, there is wisdom and vice versa."
The core of practicing Dhutanga is to end all defilements and impurities. This practice helps the practitioner guard the senses, not being influenced by circumstances, gradually eliminating greed, hatred, and delusion. That is why monastics eat only one meal a day (reducing greed for food), sleep sitting (reducing the desire for sleep, as lying down can lead to deep, excessive sleep), and wear three robes (actually one set, the minimum requirement, reducing attachment to clothing).
Some criticize why a Dhutanga practitioner does not live alone in the forest but wanders across the country. The answer is that finding forests in Vietnam today like in the Buddha's time is impossible. Venerable Minh Tue has also spent time in seclusion on Mount San. So why does he choose to walk across the country? He answers that it is to "train and maintain health." In a deeper understanding, he is practicing the true Dharma of the Tathagata. Walking helps him to be mindful of body, feelings, mind, and phenomena; living in hardship, experiencing suffering, and understanding the cause of suffering leads to the end of suffering, rather than hoping to escape suffering to find happiness.
On his journey, if he is tempted by material possessions, money, or beauty, it means that desire has arisen; if he feels troubled by the crowd, it means anger has arisen. Therefore, solitary retreat alone may not necessarily help control the mind when faced with worldly temptations.
Many people also question the social utility of his wanderings. If everyone did as he does, who would produce food? These questions are shortsighted and self-serving.
What have we done for society? Everyone contributes to society in varying degrees, and human values are not solely measured by material contributions but also by spiritual ones. Typically, what we do is visible and beneficial to ourselves and our families. In contrast, what Venerable Minh Tue has done for society is far more significant and evident:
Some people question why he refers to himself as "con" (child) instead of "thầy" (teacher).
First, he has chosen the path of renunciation, no longer bound by monastic duties at a temple, and does not consider himself anyone's teacher to avoid influencing others and bureaucratic issues.
Second, the self-reference "thầy" among monks and laypeople today is merely a convention in communication. There is no binding requirement. In essence, it is a cultural practice in Vietnamese language, while in English, it is just "I-You," or in Chinese, "Wǒ 我 - Nǐ 你." Some high-ranking monks still refer to themselves as "tôi" (I) or their Dharma names when teaching. Venerable Minh Tue's use of "con" with everyone demonstrates his practice of humility, renouncing the ego, which is the spirit of selflessness.
Currently, wherever he goes, hundreds to thousands of people follow, including many YouTubers, TikTokers, and Facebookers. This has raised concerns about security and disruptions to his practice.
I believe we should not rush to blame or criticize those creating social media content. Let's see the positive side, for without them, how could the beautiful image of a true monk spread? In this era, spreading the Dharma and sharing good things are more effective with the support of media and social networks. How else would Vietnamese Buddhists know about the teachings of monks like Phap Hoa or Tinh Khong and other high-ranking monks?
Moreover, their gathering is also a test for Venerable Minh Tue to practice mind control. If he starts feeling important, central, or like a star due to attention and veneration, he immediately falls into ego clinging and arrogance. If he gets annoyed by the crowd, it means anger has arisen. These situations are ultimate tests on the path of precepts and mindfulness. Observing him, no matter how hard the walk, his face remains serene with a smile. Perhaps he has attained tranquility.
Some people express sympathy for him, tearfully seeing him bareheaded, barefoot, under the sun and rain. This emotional response is understandable but from a worldly perspective. Choosing the path of asceticism makes him feel internal joy, and these hardships help him approach enlightenment.
Some worry about him facing dangers from dark forces. Don't worry; choosing this path requires great courage. Didn't he say, "If I'm allowed to live, I'll continue to practice"? This shows fearlessness as he has thoroughly understood impermanence and selflessness. What we should care about is whether he has truly attained this mindset. If he has, Nirvana is not far away. Therefore, we should rejoice.
I predict that at some stage, after experiencing suffering and training body and mind, Venerable Minh Tue might retreat into seclusion to achieve enlightenment. Once precepts are fully observed, meditation is necessary to attain concentration.
Certainly, his influence has reduced the income of some fraudulent monks, who might even have to sell cars and land. Therefore, it is not surprising that efforts to defame and harm Venerable Minh Tue are intensifying. Initially, they fabricated stories of false monasticism with staged filming. They ridiculed his robe, calling it "plot selling land," or criticized his rice cooker as an unofficial alms bowl. But they fail to understand that he has reached a state of non-attachment, indifferent to shame or ridicule. Having chosen a renunciant life, living without family, sleeping in cemeteries, overcoming family ties is the greatest obstacle.
The meanest tactic they use is labeling him as an agent of foreign anti-government organizations, portraying him as a beggar monk to undermine Vietnamese Buddhism and the nation.
I must say, Vietnamese Buddhism is undermined by fraudulent monks, tolerated and supported. They exploit karma and reincarnation theories, distorting and frightening the ignorant with horrific afterlife scenarios. They continue exploiting donations as a way to resolve karmic debts, seeking blessings, and accumulating merit, the more money, the better, even encouraging devotees to donate entire houses to temples and live simply elsewhere. In short, just donate.
Therefore, the purification of fraudulent monks will be the revival of Vietnamese Buddhism.
Praising Venerable Minh Tue's practice does not mean devaluing other practices of true monks in the country. Each has different capacities and vows, so not everyone can be the same. Every individual is here to fulfill a unique mission.
If the standard of a monk is virtue, clearly, the one who practices surpasses the one who understands. Practicing Dhutanga is a great merit, rarely achieved. Therefore, praising and respecting virtue is right but not deifying or idolizing Venerable Minh Tuệ at this moment, as this would lead to wrong views and contradict the spirit of Buddhism.
To understand the significance of practicing Dhutanga, let me quote the Buddha's praise of Venerable Kasyapa's practice:
“Well done! Well done, Kasyapa! You have brought great benefit and saved innumerable beings, extending this to all the realms of gods and men. Why? Kasyapa, if this ascetic practice remains in the world, then my teachings will also remain long in the world. If my teachings remain in the world, then the path to the heavenly realm will increase, and the three evil paths will diminish. Likewise, the noble paths of Sotapanna, Sakadagami, Anagami, and the Three Vehicles will also remain in the world. Monks, you should practice as Kasyapa does.
Thus, monks, you should learn this.” (4)
Notes: (1) In the Samannaphala Sutta, Kinh Chung Đức (2) Also known as Prajna Wisdom (3) In the Kinh Chung Đức (4) In the Ekottara Agama, Volume I
Nha Trang, May 10, 2024 Nguyen Thanh Huy Email: [thanhhuy1979@gmail.com]()
Editor's Note: (*) Currently a lecturer in the Department of Linguistics at the University.
submitted by Dry-Illustrator5292 to MonkMinhTue [link] [comments]
Today, Venerable Minh Tue is known by many (I prefer not to use the word "famous" for a monastic) and has widespread influence, reaching beyond national borders. The story of Venerable Minh Tue has become hotter than ever, flooding social media with videos and images of him. This has sparked a variety of opinions, ranging from admiration and respect to criticism and contempt. Many paths of human experience!
Fortunately, those who think negatively about him are still a minority.
Venerable Minh Tue practices the ascetic path of Dhutanga. Some people look at his conduct and attire and criticize him as crazy, self-mortifying, lacking wisdom, and not following the Middle Way that the Buddha encouraged. However, these critics do not realize that Venerable Minh Tue is practicing according to the correct Dharma, following the teachings of the original scriptures. He has abandoned family life, living a pure and simple life, renouncing all attachments, and practicing minimalism and contentment. People confuse the ascetic practices of Dhutanga with the severe austerities the Buddha practiced during his six years of seeking enlightenment. Those severe practices involved extreme self-mortification, causing great physical pain (originating from Brahmanism). Thus, Dhutanga in a sense is a precursor to the Middle Way and still closely aligns with it.
Many argue that monastic life should prioritize wisdom over physical asceticism. However, they confuse worldly wisdom with Buddhist wisdom. Worldly wisdom is human cognitive ability, derived from genetics and education, whereas Buddhist wisdom is only revealed when a practitioner strictly adheres to precepts. Observance of precepts leads to concentration, and concentration leads to wisdom. Therefore, the Buddha said, "Where there is virtue, there is wisdom and vice versa."
The core of practicing Dhutanga is to end all defilements and impurities. This practice helps the practitioner guard the senses, not being influenced by circumstances, gradually eliminating greed, hatred, and delusion. That is why monastics eat only one meal a day (reducing greed for food), sleep sitting (reducing the desire for sleep, as lying down can lead to deep, excessive sleep), and wear three robes (actually one set, the minimum requirement, reducing attachment to clothing).
Some criticize why a Dhutanga practitioner does not live alone in the forest but wanders across the country. The answer is that finding forests in Vietnam today like in the Buddha's time is impossible. Venerable Minh Tue has also spent time in seclusion on Mount San. So why does he choose to walk across the country? He answers that it is to "train and maintain health." In a deeper understanding, he is practicing the true Dharma of the Tathagata. Walking helps him to be mindful of body, feelings, mind, and phenomena; living in hardship, experiencing suffering, and understanding the cause of suffering leads to the end of suffering, rather than hoping to escape suffering to find happiness.
On his journey, if he is tempted by material possessions, money, or beauty, it means that desire has arisen; if he feels troubled by the crowd, it means anger has arisen. Therefore, solitary retreat alone may not necessarily help control the mind when faced with worldly temptations.
Many people also question the social utility of his wanderings. If everyone did as he does, who would produce food? These questions are shortsighted and self-serving.
What have we done for society? Everyone contributes to society in varying degrees, and human values are not solely measured by material contributions but also by spiritual ones. Typically, what we do is visible and beneficial to ourselves and our families. In contrast, what Venerable Minh Tue has done for society is far more significant and evident:
- He has helped many people see the image of original Buddhism and the monastic life of the Buddha.
- He serves as a mirror reflecting the true nature of some "fraudulent monks," "transaction monks," and "advisory monks."
- He has awakened many who were lost in false doctrines, bringing them back to the light of the true Dharma.
- He has maintained faith in Buddhism for many and earned the admiration of followers of other religions.
- He has inspired many to reflect on themselves, reducing greed, hatred, and delusion in their lives. Some have even given up everything to follow his path.
- In a way, he has brought people closer and fostered social harmony.
Some people question why he refers to himself as "con" (child) instead of "thầy" (teacher).
First, he has chosen the path of renunciation, no longer bound by monastic duties at a temple, and does not consider himself anyone's teacher to avoid influencing others and bureaucratic issues.
Second, the self-reference "thầy" among monks and laypeople today is merely a convention in communication. There is no binding requirement. In essence, it is a cultural practice in Vietnamese language, while in English, it is just "I-You," or in Chinese, "Wǒ 我 - Nǐ 你." Some high-ranking monks still refer to themselves as "tôi" (I) or their Dharma names when teaching. Venerable Minh Tue's use of "con" with everyone demonstrates his practice of humility, renouncing the ego, which is the spirit of selflessness.
Currently, wherever he goes, hundreds to thousands of people follow, including many YouTubers, TikTokers, and Facebookers. This has raised concerns about security and disruptions to his practice.
I believe we should not rush to blame or criticize those creating social media content. Let's see the positive side, for without them, how could the beautiful image of a true monk spread? In this era, spreading the Dharma and sharing good things are more effective with the support of media and social networks. How else would Vietnamese Buddhists know about the teachings of monks like Phap Hoa or Tinh Khong and other high-ranking monks?
Moreover, their gathering is also a test for Venerable Minh Tue to practice mind control. If he starts feeling important, central, or like a star due to attention and veneration, he immediately falls into ego clinging and arrogance. If he gets annoyed by the crowd, it means anger has arisen. These situations are ultimate tests on the path of precepts and mindfulness. Observing him, no matter how hard the walk, his face remains serene with a smile. Perhaps he has attained tranquility.
Some people express sympathy for him, tearfully seeing him bareheaded, barefoot, under the sun and rain. This emotional response is understandable but from a worldly perspective. Choosing the path of asceticism makes him feel internal joy, and these hardships help him approach enlightenment.
Some worry about him facing dangers from dark forces. Don't worry; choosing this path requires great courage. Didn't he say, "If I'm allowed to live, I'll continue to practice"? This shows fearlessness as he has thoroughly understood impermanence and selflessness. What we should care about is whether he has truly attained this mindset. If he has, Nirvana is not far away. Therefore, we should rejoice.
I predict that at some stage, after experiencing suffering and training body and mind, Venerable Minh Tue might retreat into seclusion to achieve enlightenment. Once precepts are fully observed, meditation is necessary to attain concentration.
Certainly, his influence has reduced the income of some fraudulent monks, who might even have to sell cars and land. Therefore, it is not surprising that efforts to defame and harm Venerable Minh Tue are intensifying. Initially, they fabricated stories of false monasticism with staged filming. They ridiculed his robe, calling it "plot selling land," or criticized his rice cooker as an unofficial alms bowl. But they fail to understand that he has reached a state of non-attachment, indifferent to shame or ridicule. Having chosen a renunciant life, living without family, sleeping in cemeteries, overcoming family ties is the greatest obstacle.
The meanest tactic they use is labeling him as an agent of foreign anti-government organizations, portraying him as a beggar monk to undermine Vietnamese Buddhism and the nation.
I must say, Vietnamese Buddhism is undermined by fraudulent monks, tolerated and supported. They exploit karma and reincarnation theories, distorting and frightening the ignorant with horrific afterlife scenarios. They continue exploiting donations as a way to resolve karmic debts, seeking blessings, and accumulating merit, the more money, the better, even encouraging devotees to donate entire houses to temples and live simply elsewhere. In short, just donate.
Therefore, the purification of fraudulent monks will be the revival of Vietnamese Buddhism.
Praising Venerable Minh Tue's practice does not mean devaluing other practices of true monks in the country. Each has different capacities and vows, so not everyone can be the same. Every individual is here to fulfill a unique mission.
If the standard of a monk is virtue, clearly, the one who practices surpasses the one who understands. Practicing Dhutanga is a great merit, rarely achieved. Therefore, praising and respecting virtue is right but not deifying or idolizing Venerable Minh Tuệ at this moment, as this would lead to wrong views and contradict the spirit of Buddhism.
To understand the significance of practicing Dhutanga, let me quote the Buddha's praise of Venerable Kasyapa's practice:
“Well done! Well done, Kasyapa! You have brought great benefit and saved innumerable beings, extending this to all the realms of gods and men. Why? Kasyapa, if this ascetic practice remains in the world, then my teachings will also remain long in the world. If my teachings remain in the world, then the path to the heavenly realm will increase, and the three evil paths will diminish. Likewise, the noble paths of Sotapanna, Sakadagami, Anagami, and the Three Vehicles will also remain in the world. Monks, you should practice as Kasyapa does.
Thus, monks, you should learn this.” (4)
Notes: (1) In the Samannaphala Sutta, Kinh Chung Đức (2) Also known as Prajna Wisdom (3) In the Kinh Chung Đức (4) In the Ekottara Agama, Volume I
Nha Trang, May 10, 2024 Nguyen Thanh Huy Email: [thanhhuy1979@gmail.com]()
Editor's Note: (*) Currently a lecturer in the Department of Linguistics at the University.
2024.05.19 05:57 ShiftedAurora Gorge camping questions :)
Hello:)
Side note, This will be my FIRST TIME attending a show at the gorge, so I apologize in advance if any of these are obvious.
Very excited for the upcoming show at the gorge! With all the EDC hype it’s been actually quite difficult to find information on this show. I’ve been finding a lot of bass canyons threads, or above and beyond threads but it seems as each show is a little bit unique as far as setup and rules go. Any help with these questions would be greatly appreciated, and I hope to see some of you at the gorge this coming up week:)
1- Food situation? So confused on the fact that it seems we CAN bring coolers in, however food needs to be placed in gallon ziplock bags? So do we put them in bags, inside of our cooler? Or do they need to be separated upon entry?
On the same thought, water? The website says only a gallon is permitted? So I cannot bring a 5 gallon water jug for hand washing and what not? How strict are they with this?
2- “Small propane grills welcome” Requirements on this? I have a stove burner that uses a normal size 5 gallon propane tank. It’s only a single burner so does this classify as a small propane grill? Do they allow propane tanks of this size?
3- Camp upgrades. Originally purchased a GA camping pass. I’ve heard some horror stories from bass canyon about the GA pop being quite rowdy, with no regard to the rules. For a show like Illenium, is this going to still be the case? Hoping to upgrade my camping pass but it says the only way to do so is on site during check in. So should we take the premier camping line and expect to upgrade, or do we wait in the GA line and tell them our situation? Has anyone had experience with upgrading your camping pass?
4- Campground opens at 4, is arriving at like 2 or 3pm too early? Or do you shoot for 4 when it opens?
5- ANY OTHER tips, things to watch for, advice or anything at all would be greatly appreciated. (We have lots of stakes for securing our camping items down)
Looking forward to this show, and I’m sure others have some questions as well so feel free to comment them down below
❤️PLUR❤️
submitted by ShiftedAurora to Illenium [link] [comments]
Side note, This will be my FIRST TIME attending a show at the gorge, so I apologize in advance if any of these are obvious.
Very excited for the upcoming show at the gorge! With all the EDC hype it’s been actually quite difficult to find information on this show. I’ve been finding a lot of bass canyons threads, or above and beyond threads but it seems as each show is a little bit unique as far as setup and rules go. Any help with these questions would be greatly appreciated, and I hope to see some of you at the gorge this coming up week:)
1- Food situation? So confused on the fact that it seems we CAN bring coolers in, however food needs to be placed in gallon ziplock bags? So do we put them in bags, inside of our cooler? Or do they need to be separated upon entry?
On the same thought, water? The website says only a gallon is permitted? So I cannot bring a 5 gallon water jug for hand washing and what not? How strict are they with this?
2- “Small propane grills welcome” Requirements on this? I have a stove burner that uses a normal size 5 gallon propane tank. It’s only a single burner so does this classify as a small propane grill? Do they allow propane tanks of this size?
3- Camp upgrades. Originally purchased a GA camping pass. I’ve heard some horror stories from bass canyon about the GA pop being quite rowdy, with no regard to the rules. For a show like Illenium, is this going to still be the case? Hoping to upgrade my camping pass but it says the only way to do so is on site during check in. So should we take the premier camping line and expect to upgrade, or do we wait in the GA line and tell them our situation? Has anyone had experience with upgrading your camping pass?
4- Campground opens at 4, is arriving at like 2 or 3pm too early? Or do you shoot for 4 when it opens?
5- ANY OTHER tips, things to watch for, advice or anything at all would be greatly appreciated. (We have lots of stakes for securing our camping items down)
Looking forward to this show, and I’m sure others have some questions as well so feel free to comment them down below
❤️PLUR❤️
2024.05.19 04:17 throwaway29837373 Anyone else tired of their boomer parents trying to pimp them out?
After years of an unhappy relationship I abruptly left in April and moved back in with my folks.
I think part of the reason it took so long to leave the relationship is because it meant I wouldn’t have to go back and listen to my shit boomer dad.
I haven’t even been here three weeks and he’s already asked if my folks can claim us (me and my two kids) as dependents on their taxes so they can get a f*cking tax break 🙄. (I work part time and attend school and have applied for food stamps).
Tonight he alleged he was going to testify in child support court and that “Things weren’t gonna go the way I thought they were.” As if the court is gonna turn over custody of my children to my parents. LOL. (Neither me nor my ex do drugs, we both work and pay our bills with what little we make and spend every moment with our kids.)
I’m just so tired of his self serving greed. Before I moved back in with them I had to agree to a $900 rent for ONE ROOM in their precious home. FUCK boomers. Sincerely.
submitted by throwaway29837373 to GenZ [link] [comments]
I think part of the reason it took so long to leave the relationship is because it meant I wouldn’t have to go back and listen to my shit boomer dad.
I haven’t even been here three weeks and he’s already asked if my folks can claim us (me and my two kids) as dependents on their taxes so they can get a f*cking tax break 🙄. (I work part time and attend school and have applied for food stamps).
Tonight he alleged he was going to testify in child support court and that “Things weren’t gonna go the way I thought they were.” As if the court is gonna turn over custody of my children to my parents. LOL. (Neither me nor my ex do drugs, we both work and pay our bills with what little we make and spend every moment with our kids.)
I’m just so tired of his self serving greed. Before I moved back in with them I had to agree to a $900 rent for ONE ROOM in their precious home. FUCK boomers. Sincerely.
2024.05.19 04:01 Beginning-Pilot7727 Food Stamp card
Can you use your food Stamp card in another state?
submitted by Beginning-Pilot7727 to foodstamps [link] [comments]
2024.05.19 03:51 Serephitus 42 packs of Twilight Masquerade - 1 BB & 2 three pack blisters
submitted by Serephitus to pokemoncards [link] [comments]
2024.05.19 03:45 Sea-Point-7313 My gf and I live together with our sons. My gf has claimed my 6 yo on her taxes. We have a newborn. I’m applying for food stamps, without including my GF. Can I put both of my sons on my food stamp application, even though I won’t claim them?
submitted by Sea-Point-7313 to foodstamps [link] [comments]
2024.05.19 02:45 The_Brand94 RIGL Thesis 5/18/2024
~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD1
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.
submitted by The_Brand94 to u/The_Brand94 [link] [comments]
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD1
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.
2024.05.19 02:42 gfdoctor Sun Bucks for Washington state folks
Sun Bucks AKA Summer EBT benefits are available to eligible families with school aged children. Families receiving Basic Food benefits and/or Free and Reduced Lunch Rates automatically qualify and will receive $120 per child.
To enroll in the program, contact the SUN Bucks Contact Center at 1-833-543-3230 (TTY: 1-800-833-6348) between 8am and 5pm Monday–Friday (except observed holidays) or visit textsunbucks.dshs.wa.gov to opt into to text alerts and to check your account status.
submitted by gfdoctor to FoodStampCooking [link] [comments]
To enroll in the program, contact the SUN Bucks Contact Center at 1-833-543-3230 (TTY: 1-800-833-6348) between 8am and 5pm Monday–Friday (except observed holidays) or visit textsunbucks.dshs.wa.gov to opt into to text alerts and to check your account status.
2024.05.19 02:27 Sufficient-Bat8282 Food recommendations
I’m GA+ and want some food/smoothies/milkshakes recommendations and location on where to get them. I tried using the map but it doesn’t the name of the food. thank you!
submitted by Sufficient-Bat8282 to electricdaisycarnival [link] [comments]
2024.05.19 02:24 XsairahmlX Aging parents.
I am 35, my dad is 70. My mom is 66.
I got a very distressing call from my dad today. My mom has muscular dystrophy, tremors (severe), and Alzheimer’s. They have been keeping this from me but her health is declining rapidly. He believes by the end of the year she will be unable to feed herself. She is totally disabled, and can barely walk even with a walker. Her mind is still cognizant- but she gets confused and lost pretty often. She has been falling 7-10 times per week and my dad is not able to pick her up any more so they have to call the fire department to come help.
My question is they seriously need help. My dad also had to quit his job two weeks ago because he can’t leave her. She has disability payments she receives, and my dad gets social security but it’s barely enough to get by. Somehow they don’t qualify for food stamps. She needs an at home care worker but they can’t afford it.
I guess I’m just reaching out to see if anyone has any suggestions, or experiences, or Reddit groups where these co furious are talked about so I can try to figure out what other millennials are doing to help their parents. They are on Medicare and he is trying to get a “hoyer lift”? In the house so he can pick her up. But as far as the at home care worker, does anyone know if you can have that paid for by the government? I mentioned he could apply to have himself paid as her caregiver, and we are looking into that but if it’s not a significant enough income they may not be able to do it.
I don’t even know where to start looking, or what programs might be available so ANY help would be so much appreciated.
I’m sorry if I’m rambling or this isn’t clear or is missing something- I’m kind of lost right now.
submitted by XsairahmlX to millenials [link] [comments]
I got a very distressing call from my dad today. My mom has muscular dystrophy, tremors (severe), and Alzheimer’s. They have been keeping this from me but her health is declining rapidly. He believes by the end of the year she will be unable to feed herself. She is totally disabled, and can barely walk even with a walker. Her mind is still cognizant- but she gets confused and lost pretty often. She has been falling 7-10 times per week and my dad is not able to pick her up any more so they have to call the fire department to come help.
My question is they seriously need help. My dad also had to quit his job two weeks ago because he can’t leave her. She has disability payments she receives, and my dad gets social security but it’s barely enough to get by. Somehow they don’t qualify for food stamps. She needs an at home care worker but they can’t afford it.
I guess I’m just reaching out to see if anyone has any suggestions, or experiences, or Reddit groups where these co furious are talked about so I can try to figure out what other millennials are doing to help their parents. They are on Medicare and he is trying to get a “hoyer lift”? In the house so he can pick her up. But as far as the at home care worker, does anyone know if you can have that paid for by the government? I mentioned he could apply to have himself paid as her caregiver, and we are looking into that but if it’s not a significant enough income they may not be able to do it.
I don’t even know where to start looking, or what programs might be available so ANY help would be so much appreciated.
I’m sorry if I’m rambling or this isn’t clear or is missing something- I’m kind of lost right now.
2024.05.19 02:00 BeigeListed Are the Republicans Sneakily Trying to Cut Food Stamps? The House GOP’s farm bill would change how SNAP benefits are evaluated, and Democrats are furious.
 | submitted by BeigeListed to Investigate_the_GOP [link] [comments] |
2024.05.19 01:50 joy-nes Should you mention transit countries?
Please help. Regarding travel history should we mention any transit countries?
I remember crossing Spain to get to France but I only mentioned France. I was in Spain for less than a day but my passport was stamped in the Spanish borders. I also spent few days in Switzerland but since there are no borders in Europe my passport doesn’t have a Swiss stamp. I already submitted my application and medicals and bio are all passed but eligibility hasn’t started yet. Should I send a web form or is it not important? Please can someone tell me what to do I’m freaking out right now.
submitted by joy-nes to ImmigrationCanada [link] [comments]
I remember crossing Spain to get to France but I only mentioned France. I was in Spain for less than a day but my passport was stamped in the Spanish borders. I also spent few days in Switzerland but since there are no borders in Europe my passport doesn’t have a Swiss stamp. I already submitted my application and medicals and bio are all passed but eligibility hasn’t started yet. Should I send a web form or is it not important? Please can someone tell me what to do I’m freaking out right now.
2024.05.19 01:30 ButterFinger084 Is the point system legal?
I work for a big company that gives us 7 points. If you reach 0, you’re fired. I lost a point for surgery saying I’m not eligible for fmla until I worked there for a year. A few due to my car breaking down, food poisoning, sick etc. I never wanted to take any of those days off. A year of misfortune got me to 1 point. I get some points back in a couple months but now I have the flu really bad and even with a doctors note it’ll be 1 point. What should I do? I don’t feel safe to work.
submitted by ButterFinger084 to work [link] [comments]
2024.05.19 01:19 AdSilent5734 Possibility of receiving extra foodstamps due to being on antidepressant in NYC?
Hi. I'm new here so idk if this has been asked before and my local food stamp office is close till Monday. I'm wondering is it possible to request (and hopefully receive)extra food stamps if i explain that I'm on antidepressants and have crhons disease. So now im eating more. But my diet has had to change alot since surgery and the foods I need to eat are kinds expensive compare to how I'm used to eating.
With both those things in mind, and inflation. i find myself going through half my monthly food stock in 9-10 days. And it's very said what $70 in groceries gets you these days. I get $291 a month and have no kids. Can I request for an increase and provide my medical documents as to why I'm asking! Thanks
submitted by AdSilent5734 to foodstamps [link] [comments]
With both those things in mind, and inflation. i find myself going through half my monthly food stock in 9-10 days. And it's very said what $70 in groceries gets you these days. I get $291 a month and have no kids. Can I request for an increase and provide my medical documents as to why I'm asking! Thanks
2024.05.19 00:58 DesperateTry2694 My friend thinks I have an ED
My friend just told me I need medical help. I am a young woman. I had quite a bit to drink and confessed my father was often making snide comments about my weight and she revealed he had done so behind my back. I have gained probably 1-2 stone within a year. She says it is not visible but I disagree as since these comments have started I have felt massive. As if I pound the ground as I walk with a large obnoxious thump. As if there is some inconceivably red letter stamped on me marking me as fat that only other people can see and judge me for. Due to exams, regular exercise has been impeded. I have every intention to return to regular exercise. I know my eating habits have never been up to par and it is something I will forever need to work on due me stress eating and comfort eating however due to monetary issues I firmly believe this can be worked on within the near future. I admitted that for me being hungry and eating and feeling sick is a never ending cycle. I feel hungry so I eat and then because I enjoy eating I feel sick from eating too much and because i feel sick I eat to feel better.
Personally I don’t feel like this is an eating disorder merely a bad relationship with food due to a lifetime as a picky eater which my parents hated. I never actually throw up it is impossible for me to throw up without it being absolutely necessary.
submitted by DesperateTry2694 to offmychest [link] [comments]
Personally I don’t feel like this is an eating disorder merely a bad relationship with food due to a lifetime as a picky eater which my parents hated. I never actually throw up it is impossible for me to throw up without it being absolutely necessary.
2024.05.19 00:34 Oliver-Clothes-Ooof Hey Laurel, has TXDHHS reached out to you yet about your food stamps? Asking for a friend. 🤭
submitted by Oliver-Clothes-Ooof to MBearSnark [link] [comments]
2024.05.19 00:21 stlatos Crimean Gothic Ingdolou ‘Lord Ing’
I have said that Heimdallr has no certain etymology for -dallr, but since heim- is certain, “lord of the world” is a possibility that arises from seeing that metathesis of *mw (since Pw is usually not allowed in IE) might exist in a sequence :
*xaimi-walda-z > *xaim-walda-z > *xaim-dalwa-z > ON Heimdallr
with the same optional changes to *lw in Latin :
*solwo- > L. salvus ‘unharmed/safe/sound’, OL sollus, Skt. sárva- ‘whole/all’
*palwo- / *pelwo- > OE f(e)alo ‘yellow’, Li. palvas ‘light yellow (reddish/brownish)’, L. fulvus ‘deep yellow / gold’
*pal(i)wo- / *pel(i)wo- / *pol(i)wo- > G. poliós ‘grey’, peliós ‘livid’, pellós ‘dark’, L. pullus ‘dark’, pallidus ‘pale’
*mulwo- > Li. mulvas ‘reddish / yellowish’, L. mullus ‘red mullet’, mulleus ‘reddish/purple shoe worn by 3 highest magistrates’
which might be related to optional alternation of Gmc. *gW / *gw / *w, since the same in :
*dwi-dhogWhlo- ‘half-light’ > OIr. dedól ‘dawn/twilight’
*dhogWhlo- > *dalwa- > *dall-inga-z > Dellingr ‘god of dawn?’
Now, new evidence of this has come to my knowledge, showing that Gmc. *dalwa-z did exist. Crimean Gothic Ingdolou, with the odd cluster -ngd-, must be a compound. Since the name Ing is well-established in Gmc., no other reasonable optiona exists. Since Ing was also called *Frauja-z ( > Freyr ) ‘lord’, a name ‘Lord Ing’ seems to fit. Since *-wV became -w (pronounced -u after consonants) in Gothic, the same (with metathesis of *ww like *mw) in :
*ingwa-walda- > *ingw-walda- > *ingw-dalwa- > *ingw-dalw > *ingw-dalu > Ingdolou
This is presumably the vocative form, with *a > o (as in others, dorbiza ~ þarba, hoem- ~ *xaim-) and ou used for [u] (the writer was Flemish). This much metathesis, seen twice, is much less than needed in other words of certain meaning :
Go. ga-hveitjan ‘to whiten’, Crim. *ga-xwit-ta- ‘whitened’ > wixtgata = vvichtgata ‘white’
Crimean Gothic already shows some changes that might make it impossible to be directly derived from Gothic (see likely *-amiz > *-ems > -emsch below). That they retained the name of a prominent Gmc. god, toasted to him and asked for his protection, makes it likely they were a group of non-Christianized Goths (at the time of the Christianization of most Goths; their later history unknown).
The name Ingdolou is seen in the drinking song :
Wara Wara ingdolou / Seu te gira Galizou / Hoemisclep dorbi za ea
Wara Wara ingdolou / Sen te gira Galizou / Hoemis clep dorbiza es (word boundaries, 2 errors due to poor printing or other mistakes)
guard (us), guard (us), Lord Ing; without you, hunger grows, and the village food is less
Hoemis ‘of the village’, Gmc. gen. *xaimisa
es ‘is’ < *isti < *Hesti
sen, L. sine ‘without’
te < PIE *t(w)e(H), here -te / *-þe is probably the clitic for all cases of ‘thou’, with n-þ > n-t (similar to OE)
Galiz-ou, Go. -uh ‘and’
Galiz-ou, Go. ga-lisan ‘gather / collect’ ( > accumulate / increase / grow )
dorbiza ‘more lacking / less’, Go. þarba ‘lack / need’, þarbs ‘needy / necessary’
clep < *xlep < Gmc. *xlaiba- ‘bread’, Go. hlaib-
wara ‘guard / protect’, ward- (rd > r like -d > 0 as in broe ‘bread’)
gira < *girdag, Go. grédags ‘hungry’, grédus ‘hunger / greed’ (rd > r like -d > 0 as in broe ‘bread’)
This song has been considered untranslatable, not Gmc., or even Turkic. Its nature is very clear, and only by ignoring sound changes from obvious cognates (-d > 0 as in broe ‘bread’) and emending them into nonexistence (Stearns 1978) have the other cognates that also lost *d been left unseen. Since so many Crimean Gothic words are almost exactly like other Gmc. cognates, the trouble linguists have had finding any matches for the words in this song must show that some sound changes existed but were ignored. In the same way, the toast :
kilemschkop ‘drain the cup’ < *kwilami(z) (sa(n)) kupan ‘let’s down/finish (this) cup’ (*gWelH- > Gmc. *kwil- ‘die / end / fall / set’)
seems to show that *s > š by C (*windaz > wintch ‘wind’, schvvester ‘sister’) either applies to *-miz > *-ms > msch or that *so > *sa became a clitic s- before words (with analogy, since *t- existed in non-nominative forms; compare likely analogy in -te above). Some analysis is made less precise since many sounds seem to be in the process of devoicing (*wira-z ‘man’ > fers), but many old languages show irregular variation (or due to dialects), so this is not a reason to give up and say it’s impossible from the start. Without taking the evidence as primary, and undestanding which sound changes to apply, no progress can be made. Manaster Ramer’s (2024) refusal to even see -kop as ‘cup’ when the translation is so clear makes little sense, and only continues a lack of reasonable analysis of even slightly difficult Crimean Gothic words.
Busbecq, A. G. (printed 1740, 1995, 2000)
http://titus.uni-frankfurt.de/texte/etcs/germ/got/krimgot/krimg.htm
Manaster Ramer, Alexis (2024, 2nd draft) Bay Mir Zestu Oys Vi a Germanishe: Crimean Gothic Connected Speech (A Toast and A Drinking Song)
https://www.academia.edu/119269732
Stearns, MacDonald (1978) Crimean gothic : analysis and etymology of the corpus
https://archive.org/details/crimeangothicana0000stea
Whalen, Sean (2023) Latin lūculentus, opulentus, violent-, vehement-
https://www.reddit.com/etymology/comments/zzfsx3/latin_l%C5%ABculentus_opulentus_violent_vehement/
submitted by stlatos to mythology [link] [comments]
*xaimi-walda-z > *xaim-walda-z > *xaim-dalwa-z > ON Heimdallr
with the same optional changes to *lw in Latin :
*solwo- > L. salvus ‘unharmed/safe/sound’, OL sollus, Skt. sárva- ‘whole/all’
*palwo- / *pelwo- > OE f(e)alo ‘yellow’, Li. palvas ‘light yellow (reddish/brownish)’, L. fulvus ‘deep yellow / gold’
*pal(i)wo- / *pel(i)wo- / *pol(i)wo- > G. poliós ‘grey’, peliós ‘livid’, pellós ‘dark’, L. pullus ‘dark’, pallidus ‘pale’
*mulwo- > Li. mulvas ‘reddish / yellowish’, L. mullus ‘red mullet’, mulleus ‘reddish/purple shoe worn by 3 highest magistrates’
which might be related to optional alternation of Gmc. *gW / *gw / *w, since the same in :
*dwi-dhogWhlo- ‘half-light’ > OIr. dedól ‘dawn/twilight’
*dhogWhlo- > *dalwa- > *dall-inga-z > Dellingr ‘god of dawn?’
Now, new evidence of this has come to my knowledge, showing that Gmc. *dalwa-z did exist. Crimean Gothic Ingdolou, with the odd cluster -ngd-, must be a compound. Since the name Ing is well-established in Gmc., no other reasonable optiona exists. Since Ing was also called *Frauja-z ( > Freyr ) ‘lord’, a name ‘Lord Ing’ seems to fit. Since *-wV became -w (pronounced -u after consonants) in Gothic, the same (with metathesis of *ww like *mw) in :
*ingwa-walda- > *ingw-walda- > *ingw-dalwa- > *ingw-dalw > *ingw-dalu > Ingdolou
This is presumably the vocative form, with *a > o (as in others, dorbiza ~ þarba, hoem- ~ *xaim-) and ou used for [u] (the writer was Flemish). This much metathesis, seen twice, is much less than needed in other words of certain meaning :
Go. ga-hveitjan ‘to whiten’, Crim. *ga-xwit-ta- ‘whitened’ > wixtgata = vvichtgata ‘white’
Crimean Gothic already shows some changes that might make it impossible to be directly derived from Gothic (see likely *-amiz > *-ems > -emsch below). That they retained the name of a prominent Gmc. god, toasted to him and asked for his protection, makes it likely they were a group of non-Christianized Goths (at the time of the Christianization of most Goths; their later history unknown).
The name Ingdolou is seen in the drinking song :
Wara Wara ingdolou / Seu te gira Galizou / Hoemisclep dorbi za ea
Wara Wara ingdolou / Sen te gira Galizou / Hoemis clep dorbiza es (word boundaries, 2 errors due to poor printing or other mistakes)
guard (us), guard (us), Lord Ing; without you, hunger grows, and the village food is less
Hoemis ‘of the village’, Gmc. gen. *xaimisa
es ‘is’ < *isti < *Hesti
sen, L. sine ‘without’
te < PIE *t(w)e(H), here -te / *-þe is probably the clitic for all cases of ‘thou’, with n-þ > n-t (similar to OE)
Galiz-ou, Go. -uh ‘and’
Galiz-ou, Go. ga-lisan ‘gather / collect’ ( > accumulate / increase / grow )
dorbiza ‘more lacking / less’, Go. þarba ‘lack / need’, þarbs ‘needy / necessary’
clep < *xlep < Gmc. *xlaiba- ‘bread’, Go. hlaib-
wara ‘guard / protect’, ward- (rd > r like -d > 0 as in broe ‘bread’)
gira < *girdag, Go. grédags ‘hungry’, grédus ‘hunger / greed’ (rd > r like -d > 0 as in broe ‘bread’)
This song has been considered untranslatable, not Gmc., or even Turkic. Its nature is very clear, and only by ignoring sound changes from obvious cognates (-d > 0 as in broe ‘bread’) and emending them into nonexistence (Stearns 1978) have the other cognates that also lost *d been left unseen. Since so many Crimean Gothic words are almost exactly like other Gmc. cognates, the trouble linguists have had finding any matches for the words in this song must show that some sound changes existed but were ignored. In the same way, the toast :
kilemschkop ‘drain the cup’ < *kwilami(z) (sa(n)) kupan ‘let’s down/finish (this) cup’ (*gWelH- > Gmc. *kwil- ‘die / end / fall / set’)
seems to show that *s > š by C (*windaz > wintch ‘wind’, schvvester ‘sister’) either applies to *-miz > *-ms > msch or that *so > *sa became a clitic s- before words (with analogy, since *t- existed in non-nominative forms; compare likely analogy in -te above). Some analysis is made less precise since many sounds seem to be in the process of devoicing (*wira-z ‘man’ > fers), but many old languages show irregular variation (or due to dialects), so this is not a reason to give up and say it’s impossible from the start. Without taking the evidence as primary, and undestanding which sound changes to apply, no progress can be made. Manaster Ramer’s (2024) refusal to even see -kop as ‘cup’ when the translation is so clear makes little sense, and only continues a lack of reasonable analysis of even slightly difficult Crimean Gothic words.
Busbecq, A. G. (printed 1740, 1995, 2000)
http://titus.uni-frankfurt.de/texte/etcs/germ/got/krimgot/krimg.htm
Manaster Ramer, Alexis (2024, 2nd draft) Bay Mir Zestu Oys Vi a Germanishe: Crimean Gothic Connected Speech (A Toast and A Drinking Song)
https://www.academia.edu/119269732
Stearns, MacDonald (1978) Crimean gothic : analysis and etymology of the corpus
https://archive.org/details/crimeangothicana0000stea
Whalen, Sean (2023) Latin lūculentus, opulentus, violent-, vehement-
https://www.reddit.com/etymology/comments/zzfsx3/latin_l%C5%ABculentus_opulentus_violent_vehement/
2024.05.19 00:12 PlantBasedDelinquent I really need help and idk what to do. I need some money tonight urgently
Anything helps, and I will do everything in my power to repay you.
I have never been so low in my life.
My car was repossessed.
My house is foreclosing, first court date is first week of June.
I have over $30k of credit card debt.
I was laid off of work and haven't had luck with my job search, especially without transportation.
Every "friend" I had has robbed me. It adds up to thousands. They use me until I have nothing left then they take it all and leave.
My mother is unemployed without any income or effort, and I cannot help but help her as much as I possibly can.
I hate begging. I used to reject any money or gifts from people because I am a giver. But I don't know what to do. I don't want to do anything that involves selling my body and I have no belongings left to sell. Even my phone is broken and I can't afford a new one.
I am so lost and so alone. I need help. I need help so bad.
I am willing work for it or pay it back if needed as I don't expect hand outs, but anything at all is appreciated. I am a 26 year old female from MA. My mother owned her house but town tried to take it due to 12 years of neglected property tax, in turn I bought her house and had the mortgage in my name, even though she was going to live there and pay the mortgage just using my name as her credit sucks. She lied about paying it and didn't give me the account information but I trusted her, stupidly, now it's too late. If I can't save it I want to fix it up as much as I can while I have time left. She put ruined my credit further, put me in collections with home owners insurance, and broke her promises of it only being a year until we sell, and her giving me the cash to pay my car off. Now I have no car and no home soon. I had perfect credit and $30k of available credit cards in good standing but my ex racked them up to the point they all maxed. Not only did he use them without my permission sometimes, but I couldn't eat in front of him and watch him go hungry, I just couldn't. I had to support him too. He couldn't hold a job. And when enough was enough and I said no more, he would abuse and threaten me. I do everything for everyone I care about but no one is there for me. I legit can't afford food tonight. I only get $22 in food stamps.
I need it help immediately and I don't know what to do
My cashapp is $Aceeee98, Venmo @ Aislyn-B, and Paypal @ AislynB. Thank you in advance
submitted by PlantBasedDelinquent to INeedMoneyNow [link] [comments]
I have never been so low in my life.
My car was repossessed.
My house is foreclosing, first court date is first week of June.
I have over $30k of credit card debt.
I was laid off of work and haven't had luck with my job search, especially without transportation.
Every "friend" I had has robbed me. It adds up to thousands. They use me until I have nothing left then they take it all and leave.
My mother is unemployed without any income or effort, and I cannot help but help her as much as I possibly can.
I hate begging. I used to reject any money or gifts from people because I am a giver. But I don't know what to do. I don't want to do anything that involves selling my body and I have no belongings left to sell. Even my phone is broken and I can't afford a new one.
I am so lost and so alone. I need help. I need help so bad.
I am willing work for it or pay it back if needed as I don't expect hand outs, but anything at all is appreciated. I am a 26 year old female from MA. My mother owned her house but town tried to take it due to 12 years of neglected property tax, in turn I bought her house and had the mortgage in my name, even though she was going to live there and pay the mortgage just using my name as her credit sucks. She lied about paying it and didn't give me the account information but I trusted her, stupidly, now it's too late. If I can't save it I want to fix it up as much as I can while I have time left. She put ruined my credit further, put me in collections with home owners insurance, and broke her promises of it only being a year until we sell, and her giving me the cash to pay my car off. Now I have no car and no home soon. I had perfect credit and $30k of available credit cards in good standing but my ex racked them up to the point they all maxed. Not only did he use them without my permission sometimes, but I couldn't eat in front of him and watch him go hungry, I just couldn't. I had to support him too. He couldn't hold a job. And when enough was enough and I said no more, he would abuse and threaten me. I do everything for everyone I care about but no one is there for me. I legit can't afford food tonight. I only get $22 in food stamps.
I need it help immediately and I don't know what to do
My cashapp is $Aceeee98, Venmo @ Aislyn-B, and Paypal @ AislynB. Thank you in advance
2024.05.19 00:08 Homo-Sapien11 Can I gift a car to my out-of-state daughter? If not, how do I transfer the title and registration to her? Do both of us have to be in PA or GA to notarize?
Hi all,
I am trying to transfer my title and registration to my daughter who lives in GA. I wonder if we're eligible to apply for the form MV-13ST?
She moved to GA last year and took the car with her. I originally purchased the car for her under payment plans, but we just paid it off and want to transfer the title for her. We're trying to figure out the process.
submitted by Homo-Sapien11 to Pennsylvania [link] [comments]
I am trying to transfer my title and registration to my daughter who lives in GA. I wonder if we're eligible to apply for the form MV-13ST?
She moved to GA last year and took the car with her. I originally purchased the car for her under payment plans, but we just paid it off and want to transfer the title for her. We're trying to figure out the process.
- Do I do all the paperwork in PA? Does she need to be in person at the auto tag in PA to do this?
- I am going to GA to visit her in July and wonder if we can get it done there?
- Other things we should know for this process?
- She's also a veteran and do we have to pay for the sale tax when we transfer if the MV-13ST is not eligible for us.
- What are the fees that we should be aware of?
2024.05.19 00:02 EmployeeAromatic6118 What are your opinions on Voter ID?
On one hand I understand the liberal perspective that the right is just fear mongering and voter fraud is extremely rare so there is no point. However on the other hand to me it doesn’t seem that extreme to require someone to present ID when they vote, especially considering all the other things that require ID.
Things that require an ID include: Applying for welfare, applying for food stamps, applying for a job, renting, opening a bank account, driving, getting a room at a hotel, buying alcohol/nicotine, purchasing a gun, etc.
I honestly am confused how people survive without an ID in the first place, but nonetheless think government should pay for them if they are going to require them in all these instances. So would you be opposed to voter ID if IDs were payed for by the government?
submitted by EmployeeAromatic6118 to AskALiberal [link] [comments]
Things that require an ID include: Applying for welfare, applying for food stamps, applying for a job, renting, opening a bank account, driving, getting a room at a hotel, buying alcohol/nicotine, purchasing a gun, etc.
I honestly am confused how people survive without an ID in the first place, but nonetheless think government should pay for them if they are going to require them in all these instances. So would you be opposed to voter ID if IDs were payed for by the government?
2024.05.18 23:48 PlantBasedDelinquent Anything helps, and I will do everything in my power to repay you.
I have never been so low in my life.
My car was repossessed.
My house is foreclosing, first court date is first week of June.
I have over $30k of credit card debt.
I was laid off of work and haven't had luck with my job search, especially without transportation.
Every "friend" I had has robbed me. It adds up to thousands. They use me until I have nothing left then they take it all and leave.
My mother is unemployed without any income or effort, and I cannot help but help her as much as I possibly can.
I hate begging. I used to reject any money or gifts from people because I am a giver. But I don't know what to do. I don't want to do anything that involves selling my body and I have no belongings left to sell. Even my phone is broken and I can't afford a new one.
I am so lost and so alone. I need help. I need help so bad.
I am willing work for it or pay it back if needed as I don't expect hand outs, but anything at all is appreciated. I am a 26 year old female from MA. My mother owned her house but town tried to take it due to 12 years of neglected property tax, in turn I bought her house and had the mortgage in my name, even though she was going to live there and pay the mortgage just using my name as her credit sucks. She lied about paying it and didn't give me the account information but I trusted her, stupidly, now it's too late. If I can't save it I want to fix it up as much as I can while I have time left. She put ruined my credit further, put me in collections with home owners insurance, and broke her promises of it only being a year until we sell, and her giving me the cash to pay my car off. Now I have no car and no home soon. I had perfect credit and $30k of available credit cards in good standing but my ex racked them up to the point they all maxed. Not only did he use them without my permission sometimes, but I couldn't eat in front of him and watch him go hungry, I just couldn't. I had to support him too. He couldn't hold a job. And when enough was enough and I said no more, he would abuse and threaten me. I do everything for everyone I care about but no one is there for me. I legit can't afford food tonight. I only get $22 in food stamps.
I need it help immediately and I don't know what to do
My cashapp is $Aceeee98, Venmo @ Aislyn-B, and Paypal @ AislynB. Thank you in advance
submitted by PlantBasedDelinquent to INeedMoneyNow [link] [comments]
My car was repossessed.
My house is foreclosing, first court date is first week of June.
I have over $30k of credit card debt.
I was laid off of work and haven't had luck with my job search, especially without transportation.
Every "friend" I had has robbed me. It adds up to thousands. They use me until I have nothing left then they take it all and leave.
My mother is unemployed without any income or effort, and I cannot help but help her as much as I possibly can.
I hate begging. I used to reject any money or gifts from people because I am a giver. But I don't know what to do. I don't want to do anything that involves selling my body and I have no belongings left to sell. Even my phone is broken and I can't afford a new one.
I am so lost and so alone. I need help. I need help so bad.
I am willing work for it or pay it back if needed as I don't expect hand outs, but anything at all is appreciated. I am a 26 year old female from MA. My mother owned her house but town tried to take it due to 12 years of neglected property tax, in turn I bought her house and had the mortgage in my name, even though she was going to live there and pay the mortgage just using my name as her credit sucks. She lied about paying it and didn't give me the account information but I trusted her, stupidly, now it's too late. If I can't save it I want to fix it up as much as I can while I have time left. She put ruined my credit further, put me in collections with home owners insurance, and broke her promises of it only being a year until we sell, and her giving me the cash to pay my car off. Now I have no car and no home soon. I had perfect credit and $30k of available credit cards in good standing but my ex racked them up to the point they all maxed. Not only did he use them without my permission sometimes, but I couldn't eat in front of him and watch him go hungry, I just couldn't. I had to support him too. He couldn't hold a job. And when enough was enough and I said no more, he would abuse and threaten me. I do everything for everyone I care about but no one is there for me. I legit can't afford food tonight. I only get $22 in food stamps.
I need it help immediately and I don't know what to do
My cashapp is $Aceeee98, Venmo @ Aislyn-B, and Paypal @ AislynB. Thank you in advance
2024.05.18 23:43 MoochoMaas Are the Republicans Sneakily Trying to Cut Food Stamps? The House GOP’s farm bill would change how SNAP benefits are evaluated, and Democrats are furious.
| | submitted by MoochoMaas to GQP [link] [comments] |