Estradiol adderall

Age - 38
Sex - f
Height - 5’5”
Weight - 155lbs
Race - Caucasian
Duration of complaint - 3-6 weeks
Location - southeastern USA
Any existing relevant medical issues - n/a
Current medications - prozac 20mg/day; adderall 10-20mg/day; Benadryl 50mg/day; trazadone 50-100mg/day
I smoke marijuana multiple times a day.
I am on birth control (norgestimate and ethinyl estradiol tablets usp .25 mg/ .035mg) but have been inconsistent with the times I’ve taken it.
I believe I am between 3-6 weeks pregnant. I have 6–12 drinks a day and have had that habit far longer than 6 weeks. I smoke almost a pack of cigarettes a day.
Have I already done irreparable damage? I had no idea the impact of my actions and I am spiraling thinking about the consequences of my own actions.

Demographics: 34F, 5’04, 187lbs. Medications include adderall and estradiol patch as I am two years post-op from hysterectomy/bilateral oopherectomy and in surgically-induced menopause.
This post pertains to an injury to my left hand/wrist
Images: https://imgur.com/a/1963hdX
This last Sunday, I was holding the guideline attached to a large limb (10” diameter branch) on a tree that we were cutting off. While my husband was about halfway through with the limb cut, the branch suddenly splintered and, instead of breaking free of the tree, hinged downwards and away from me, pulling me very violently with it. My hand had become tangled in the guideline. It yanked me and the rope cinched very tightly around my hand.
Urgent care that day diagnosed me with a distal radial styloid fracture on these x-rays.
Today (4 days out), I followed up with an orthopedist who told me that these don’t show a fracture but rather are showing my nutrient foramen channel. She indicated that the injury was is likely just soft tissue and for me to take it easy and return in two weeks to see if I’ve regained full feeling in my fingers (instead of the current pins/needles/burning).
My wrist and hand are in a great deal of pain and still pretty swollen. I tried looking online a bit this afternoon to find a nutrient foramina on x-ray but struggled to find one that looked remotely similar to mine. I’m wondering if I should consider seeing another orthopedist for a second opinion?

Hey guys,
Long story short I had severe adrenal fatigue due to severe trauma and stress in my life a couple years ago and just abusing caffeine, adderall. I pretty much recovered and feel great.
I just started taking dhea 100mg (feb 15 this year) and first few weeks it was amazing - more energy- adrenaline - way less anxiety - better focus - emotional control - confidence - gym strength has shot through the roof and more drive. But last couple weeks that started disappearing. so I figured to do some blood work and estradiol came back at 56 and my tsh was a 5. So I guess I have to cut out dhea supplement.
My questions are
1- if I stop it, will my estradiol/tsh levels go back to normal range on their own? I’m assuming so.
2 - Also thinking of adding in DIM(lmk your thoughts)
3 - I would love to take it again but maybe 5mg once I detox and my levels are back to normal range?
Appreciate your inputs!

Halloooo,
Ive been on Sertraline 100mg, Adderall XR 15mg, and Syeda (drospirenone and ethinyl estradiol) for about 6 months. Been trying numerous different meds to help with sleep. I started taking Lamotrigine, and Quetiapine, both starting two weeks ago. I’m now taking 50mg of Lamotrigine at night, for mood issues, and the Quetiapine 50mg has been the only thing that has helped with my sleep.
In the last two weeks I have been vomiting up to 6 times a day, I’ve been eating less because I dont like throwing up tillamook cheese god that was horrific. It can be as small as two bites of a bagel. I am not necessarily nauseous throughout the day, and I tend to throw up mostly in the evenings. I only get nauseous about 30 seconds before I need to puke. Lately ive been puking mostly bile. Im not bothered by puking, but I feel bad disappearing at work every 45 minutes or so.
I have found more info on Lamotrigine causing nausea and vomiting, compared to the Quetiapine, but I was wondering if anyone has any input or experience with this. I am meeting with my Provider next week so hopefully I can get some answers. Its a shame because I feel both the Lamotrigine and Quetiapine have been quite helpful, just a shame im so vomity.
Might just be my body adjusting to the meds and might go away in a few weeks, but god i cant eat those tillamook cheese slices anymore without feeling sooooo ill.
Thanks kittens<3 mwah kisses forever

Not asking for advice, asking for someone to make this make sense for me.
I have had genetic testing done and am a CYP2 D6 intermediate metabolizer. This has proven true to me with SSRI's as they stack up in my system and caused me to become manic or, as with Wellbutrin, psychotic. On my genesite test, it says I can use most amphetamines as directed. I recently started Adderall instant release and wanted to start very low and go very slow due to how other drugs I have taken in the past metabolized through 2D6 have affected me. This includes past recreational use of MDMA and psilocybin… Not recommended.
In any case I am finding the Adderall is like coffee to me and even at 30 mg is in and out within a couple of hours. I have no real side effects… My heart rate has not really increased a whole lot and I'm even sleeping better. I feel less anxious and less depressed. I am a little confused why Adderall is wearing off so quickly with no side effects but if I took a Prozac for two days would be a hallucinating ball of panic attacks I am an ultra rapid metabolizer of cyp 219 however which does explain my rapid metabolism for coffee. Thoughts?
COMT High Activity VAL/VAL This patient is homozygous for the Val allele of the Val158Met polymorphism in the catechol-o-methyltransferase gene. Carriers of this genotype are more likely to have a typical response to stimulant medications.
ADRA2A Typical Response C/G This patient is heterozygous for the -1291G>C polymorphism in the adrenergic alpha-2A receptor gene. They have one copy of the G allele and one copy of the C allele. This genotype suggests a typical response to certain ADHD medications.
PHARMACOKINETIC GENES PK Intermediate Metabolizer CYP2D6 1/4 CYP2D61 allele enzyme activity: Normal CYP2D64 allele enzyme activity: None This genotype is most consistent with the intermediate metabolizer phenotype. This patient may have reduced enzyme activity as compared to individuals with the normal phenotype.
I'm not on any 2d6 inhibitors, other than caffeine sometimes; I also take magnesium, ashwaganda, omega oils, estradiol (had a radical hysterectomy), Ativan prn. 44f, healthy weight and no medical conditions. I'm an RN and the clarity I do have when the Adderall works is life-changing. It definitely works and works well… Just not for long.

Hi,
51f - history of eczema or psoriasis (biopsy said “psoriaform eczematous….”) currently not medicated and not an issue.
Current diagnoses - anxiety, depression, ADD, obesity, menopausal.
Issues currently dealing with - insomnia - can fall asleep, but wake up at 3am and can’t fall back; low libido; hair loss; itchy skin, tired all the time, achy joints (nothing terrible, but usually stiff when I wake up.)
Medications - Adderall 20mg, Wellbutrin 150mg, HRT - estradiol, medroxyprogesterone, estrogen-methyltestosterone; Nutrafol vitamins.
5’3”, 158lbs
New doctor ran labs - those not WNL = Eosinophils - 700 TSH - 4.69 (Free T4 is 1.2) Total cholesterol - 213 LDL - 137 Non HDL - 160
His only comment to me was to watch what i eat & avoid fried foods, but truthfully, I really don’t eat a lot of fried foods anyway. (I actually don’t eat a lot to begin with.)
I’m wondering if I should be concerned about the high eosinophils. Admittedly, I am not a doctor, but Google made me nervous.
Thank you for any insight or suggestions or even if it’s just to tell me to calm the eff down….lol.

20 FTM (female to male), obese, taking testosterone, venlafaxine, adderall, Vyvanse, avorastatin, finasteride, hydroxyzine (rarely), quetiapine, famotidine, Norethindrone, ibuprofen, vitamin D, estradiol for atrophy, and I use topical minoxidil on my face for facial hair growth
I know I take several medications that can impact blood pressure. However, i always have normal blood pressure when I get it done. I see my endocrinologist every 6 months who does blood work and takes my blood pressure. I’ve also had a few other appointments where they’ve taken it recently (most recent was a sleep doctor to see about a sleep study for sleep apnea).
Occasionally i have times where I feel kinda weird. It feels like when I had low iron when I used to menstruate. I haven’t menstruated in three years. I had very heavy periods and would sometimes feel dizzy and nauseous, i would get pale and fatigued. Never passed out though. It doesn’t feel exactly like that, but it’s the closest thing I’ve experienced.
I thought maybe it was low blood sugar. My last two fasting glucose levels were low, barely, and normal, barely.
But thinking about my meds now I’m wondering if it’s blood pressure? My blood pressure is always normal though. I want to reiterate that times where I feel like this are not common, but not rare? I’m not sure. I felt it earlier today, and prior to then i felt it around the beginning of February. I’ll start recording it to keep track. It usually stops after I eat something.
I do also have fatigue issues in general. I feel tired daily and have for as long as I can remember, hence the sleep study
Like I said I get blood work done regularly so if you have any questions about the blood work I’ll happily share
Thank you

To start I'm 27 and a trans woman, im 5'7 and my weight has been hovering around 240lbs. I do not smoke, but my mother does and I've been around her most my life. I take medication for ADHD(Adderall), anxiety(ativan and buspirone), insomnia(trazodone), and depression(fluoxetine). I also take HRT(spironolactone, Progesterone and estradiol valerate) and on occasion will have a thc gummy. I don't know how relevent it is but I'm also diagnosed with ASD.So every 3-5 months I'll experience some severe breathing problems, I feel like I'm not getting enough air and I reflexively start taking rapid l, sharp, shallow breaths, and when i exhale i occasionally make this weird squeaking sound. It comes in fits, the fits usually last a few minutes and I'll experience them intermittently for 1-7 days. Sometimes it gets so bad i almost pass out, and I have actually passed out once due to this. I've had doctors look into it but nothing conclusive. I'm really concerned about this and am wondering if anyone has any ideas or suggestions.

I am a mtf who currently takes dutasteride, estradiol valerate, and bicalutamide, and topiramate. (I also take vyvanse, adderall, and lexapro. I'll include it for the record.)
I'm experiencing some hair loss ... I read on a drug interaction checker that:
"topiramate will decrease the level or effect of dutasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. MinoSignificance Unknown."
This thread also points to evidence that even topiramate could be potentially altering bicalutamide's effectiveness with enzyme CYP3A4: https://www.reddit.com/asktransgendes/qSfdTqwZYv
some big pointers here... I'm a mtf of 16 months who quit Spiro and progesterone (200mg) cold turkey and switched right to bica + increased my estradiol valerate to 3ml a week (40mg bottle), from 2.5ml. This was essentially to "restart" my physical transition (in my mind), by eliminating the other hormones and just giving an increased dose of estrogen a chance to do it's work in all it's glory. A risky experiment I guess. I felt spiro compromised some things, both from my mental and physical health. Definitely not my hairline though.
I like what I'm seeing a little bit so far out solo estrogen just shy of 3 weeks.... I think. However, I AM already seeing some hair loss. Not good. I'm concerned.
Any input? I feel like this thread good be helpful for others as well. Thanks. ❤️.

I am a mtf who currently takes dutasteride, estradiol valerate, and bicalutamide, and topiramate. (I also take vyvanse, adderall, and lexapro. I'll include it for the record.)
I'm experiencing some hair loss ... I read on a drug interaction checker that:
"topiramate will decrease the level or effect of dutasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. MinoSignificance Unknown."
This thread also points to evidence that even topiramate could be potentially altering bicalutamide's effectiveness with enzyme CYP3A4: https://www.reddit.com/asktransgendes/qSfdTqwZYv
some big pointers here... I'm a mtf of 16 months who quit Spiro and progesterone (200mg) cold turkey and switched right to bica + increased my estradiol valerate to 3ml a week (40mg bottle), from 2.5ml. This was essentially to "restart" my physical transition (in my mind), by eliminating the other hormones and just giving an increased dose of estrogen a chance to do it's work in all it's glory. A risky experiment I guess. I felt spiro compromised some things, both from my mental and physical health. Definitely not my hairline though.
I like what I'm seeing a little bit so far out solo estrogen just shy of 3 weeks.... I think. However, I AM already seeing some hair loss. Not good. I'm concerned.
Any input? I feel like this thread good be helpful for others as well. Thanks. ❤️.

This is my first time making a post like this, so if you need more information about other blood tests like lipid, CBC, metabolic panel, etc. just let me know. I decided to make this post to troubleshoot some issues with unbiased people who have some knowledge of hormones (either professionals or people who have a background in dealing with their hormone imbalances). I am currently in college (across the country) and I don’t have access to my primary care doctors or in-network doctors. My psychiatrist was the one to order the blood tests as a favor.
I’m a 20-year-old male looking for solutions to optimize my hormones. I think the changes in my recent life are because of non-optimal hormone balances. I feel tired 24/7, my libido could be better, lots of brain fog, and I’ve lost a lot of drive/motivation to do daily tasks.
Background: I’m a late bloomer. I was 100lbs, until the middle of my senior year of high school. My family has a history of hormone problems and thyroid problems, like hypehypothyroidism. My natural metabolism is very high and it is very difficult to gain any weight. Also, I have extreme ADHD and I’ve been taking Vyvanse for the past 2 years (took Adderall for 5 years in elementary school). Some of these problems are from this medication but it’s hard to function without it. I am planning on getting off of it after college.
Life the past 2 years:
Halfway through my senior year of high school, I decided to fully dedicate myself to the gym. I am now 150-155 lbs on lean muscle. My schedule was to wake up at 4:30-5 am every day to work out before my summer job or school (I love waking up this early). I love going to the gym and go 6 days a week for 1 ½ - 2 hours a day. I also try to eat around 3600 calories a day and take basic health supplements.
Present:
In the past 6 months, I’ve noticed certain negative symptoms getting worse and it’s affecting all areas of my life. I’m tired 24/7 (even though I get 8-9 hours of sleep every day), lack the drive/motivation to do daily tasks, my brain fog is getting worse, and my libido is decreasing. My psychiatrist thinks that I might have a low level of narcolepsy, but is confused because if I did the Vyvanse should be helping with that.
The blood tests show that my hormones are in the healthy range. But, this is affecting me to the point that my grades in school are slipping, I no longer wake up early in the morning because it’s gotten too hard to do, and my gym routine is ruined. It’s changed to only 30-40 minutes at the gym (working to failure) and only going 4-5 days a week because of my messed up daily schedule, school assignments, and overall fatigue.
I like my “natural” status for the gym but, I’m worried about my other responsibilities in life. Any suggestions on how I can optimize my hormones to get my life back together? Thank you for your guys’ help.
General Hormones:
FSH- 1.0 mlU/mL
LH- 6.7 mlU/mL
TSH W/Reflex to FT4- 1.57 mlU/L
Prolactin- 13.4 ng/mL
Total Testosterone- 640 ng/dL
Estradiol- 34 pg/mL
Thyroid:
T3 uptake- 29%
T4 (THYROXINE), TOTAL- 10.3 mcg/dL
FREE T4 INDEX (T7)- 3.0
TSH- 1.37mlU/L

20 FTM (female to male). Overweight. Suspected sleep apnea (I have an in office sleep study in March to see). I take several meds. Testosterone, venlafaxine, Vyvanse, adderall, quetiapine at night for nightmares, avorastatin (my cholesterol levels are now just above normal), Norethindrone, estradiol, and finasteride. I also take ibuprofen and sometimes acetaminophen for vaginal atrophy pain
This morning I woke up with a headache. Like, the headache literally woke me up. This was around 9/9:30 am. Now at nearly 12 my head hurts again. I’ve ate breakfast so I don’t think it’s food related
What can be the cause for headaches in the morning?
This is the first time I’ve ever had a headache wake me up

Because of reasons I felt compelled to start HRT back up again last Sunday after multiple posts on Reddit. 7 doses of spiro (one taken daily in evening) and 2 doses of estradiol (via intramuscular injection once per 5 days) later and here I am.
This would mark the 20th+ time this happens.
While on HRT, I get the impression the best thing for me is to be off of HRT. I guess this comes with experiencing genderfluidity? If I even am that. I honestly can’t help but continuously think I am simply a gay man and that’s all. I feel it’s an unchangeable fact about me, and I actually feel so at home with this identity – at least while on HRT. While on HRT I feel perfectly ok with everything essentially and as though I can weather any storm.
Maybe what I need is to go through is 2 years or something off of HRT – just to be sure. Just to be sure of what? I don’t even know.
I just don’t want to lost these next 2 years to arrive at an answer that had I stayed on HRT – would mean that I am 2 years behind on physical changes achieved via HRT that would have otherwise been mine. But maybe through these 2 years with my “natural” hormone (testosterone) resetting back to essentially normally eventually, I will find the HRT thing I did that consumed my life over 2.5 years was just a wild and incredibly strange fingerpost in me figuring out myself – that after everything I am simply gay man and that’s all.
I am not sure I care any longer about living the most “abundant” and realized life (when it comes to relationships and sex), but simply one where I live my truth. Whatever that is. Even if it means living a life where I am with immensely less of relationships (of all kind) and sex.
This has all been despite NOT being chronically online by the way. My screentime the last weeks averaged 1.5 daily. 2.5 weeks on keto (under 25 carbs) daily; eating the same thing basically daily: wild caught salmon, free-range organic eggs, turkey, bone broth, MCT oil, vitamins and wide range of supplements. 15-minute red light and 4-minute cryotherapy sessions (inside -220 F chamber) each 3 times a week MWF. Weightlifting. Exercising. New med regimen that consists of small dose of anti-depressant and Adderall daily in AM. Got for the first time diagnosed with ADHD about 3 weeks ago.
TLDR: About 2-3 years ago, I realized I could be really really hot as a woman if I transitioned and have a far far better sex, love, and in general relationships aspects of my life. I went all in, killed my libido as I knew it, forever changed my brain chemistry, and now am continuously in this I don’t know what I am state. Off of HRT, with my libido back, it’s woman. Maybe with ADHD medication I’m on now, if I was off of HRT I could get back into being a guy again?
To the young ones reading, if things are fine as they are, don’t jump about the medical transition boat. There are so many risks involved including in possibility of user errors with intramuscular injections. Also, with all forms of HRT in general. If this isn’t you, if your life is fine without transitioning, think long and hard and consider all things including things you otherwise wouldn’t.

Because of reasons I felt compelled to start HRT back up again last Sunday after multiple posts on Reddit. 7 doses of spiro (one taken daily in evening) and 2 doses of estradiol (via intramuscular injection once per 5 days) later and here I am.
This would mark the 20th+ time this happens.
While on HRT, I get the impression the best thing for me is to be off of HRT. I guess this comes with experiencing genderfluidity? If I even am that. I honestly can’t help but continuously think I am simply a gay man and that’s all. I feel it’s an unchangeable fact about me, and I actually feel so at home with this identity – at least while on HRT. While on HRT I feel perfectly ok with everything essentially and as though I can weather any storm.
Maybe what I need is to go through is 2 years or something off of HRT – just to be sure. Just to be sure of what? I don’t even know.
I just don’t want to lost these next 2 years to arrive at an answer that had I stayed on HRT – would mean that I am 2 years behind on physical changes achieved via HRT that would have otherwise been mine. But maybe through these 2 years with my “natural” hormone (testosterone) resetting back to essentially normally eventually, I will find the HRT thing I did that consumed my life over 2.5 years was just a wild and incredibly strange fingerpost in me figuring out myself – that after everything I am simply gay man and that’s all.
I am not sure I care any longer about living the most “abundant” and realized life (when it comes to relationships and sex), but simply one where I live my truth. Whatever that is. Even if it means living a life where I am with immensely less of relationships (of all kind) and sex.
This has all been despite NOT being chronically online by the way. My screentime the last weeks averaged 1.5 daily. 2.5 weeks on keto (under 25 carbs) daily; eating the same thing basically daily: wild caught salmon, free-range organic eggs, turkey, bone broth, MCT oil, vitamins and wide range of supplements. 15-minute red light and 4-minute cryotherapy sessions (inside -220 F chamber) each 3 times a week MWF. Weightlifting. Exercising. New med regimen that consists of small dose of anti-depressant and Adderall daily in AM. Got for the first time diagnosed with ADHD about 3 weeks ago.
TLDR: About 2-3 years ago, I realized I could be really really hot as a woman if I transitioned and have a far far better sex, love, and in general relationships aspects of my life. I went all in, killed my libido as I knew it, forever changed my brain chemistry, and now am continuously in this I don’t know what I am state. Off of HRT, with my libido back, it’s woman. Maybe with ADHD medication I’m on now, if I was off of HRT I could get back into being a guy again?
To the young ones reading, if things are fine as they are, don’t jump about the medical transition boat. There are so many risks involved including in possibility of user errors with intramuscular injections. Also, with all forms of HRT in general. If this isn’t you, if your life is fine without transitioning, think long and hard and consider all things including things you otherwise wouldn’t.

Just want to start off with, I already made an appointment with my doctor. I just want to see if others experienced something similar
I recently start taking estradiol patches and spironolactone around October and in my most recent blood work my liver enzymes were much higher than average. The only new medication I have had during October and now other than for transitioning has been Adderall for my adhd. Was told to stop taking spironolactone and limit adderall but the estrogen patches should be fine.
If anyone has gone through something similar, would live to hear a little about it. Thanks in advance!

30 Male. 185lbs, 5'7. Maintaining 15-17% BF. Have been consistently working out (4-5x per week) for the past 12 years. Over the past 4 years, I have seen a significant decline in my general mood, energy levels and overall performance (both in the gym and in regular life). No PED's. Standard otc supplements and vitamins- Multi vitamins, D, Zinc, B12, Magnesium, Creatine, Whey etc.
Muscle and strength gains have plateaued. Have really hard time moving past my status quo. While putting on size and getting stronger is still important to me, energy and drive are my biggest concerns.
Decided to finally get my blood tests done.
Test levels back in 2020 (my earliest blood test to date) were:
Total Test- 538 ng/dL with Ref range of 249-836.
Free Test- 120 pg/mL with Ref range of 47-244.
Things started to really feel worse in 2023. Did tests in the beginning, middle and end of the year.
January 2023
Total test- 446ng/dL with Ref range of 250-1100
Free Test- 70.9 pg/mL with Ref range of 35-155
SHGB- 23 nmol/L with Ref range of 10-50.
June 2023
Total Test- 355ng/dL (dont have ref range on this one)
December 2023
Total Test- 300ng/dL with Ref range of 250-827.
Really wishing I had more consistent tests performed with same lab and same panels but different doctors etc made different test orders.
Was out of the country for the month of January 2024 and figured I'd get my start of year test done as it was cheap and wanted to look at other things in my panel as well. Need help understanding what I should be looking at and focusing on. At this point I'm at my wits end. I get it, as we get older levels will start to fall off, but seems like my body decided to take a dump as soon as I hit 30. Nothing in my lifestyle has changed from what it was 4 years ago. Stopped taking Adderall roughly 2 years ago. Not sure if that will play much of a role.
My diets and caloric intake has been good (roughly 3k maintenance calories, 2500 for summer cuts), workout routines and consistency have been as it was for the past decade. I'd like to say my knowledge and understanding of working out and dieting is relatively good as I've been doing it for 12 years and have helped and coached many people to get in shape. While I'm happy about the progress I've helped others achieve, I am damn pissed off at my lack of progress.
While TRT appears to be a viable solution, I would very much rater exhaust all potential options/remedies naturally and attempt to address the potential underlying issue in my physiology. If I can find a way to have my body get back to optimal levels via its own mechanism, that would be preferred. Tired of doctors saying you're low but you're fine.
With that being said, can someone help me understand what levels on this test below appear to be good vs not good. Some of the numbers are different than what I am used to.
Thank you all in advance!
T3, Free 3.47 pg/mL REF 2.0 - 4.4
T4, Free 1.13 ng/dL REF 0.89 - 1.76
Thyroid Stimulating Hormone (TSH) 0.93 μIU/mL REF 0.27 - 4.20
Follicle-Stimulating Hormone 3.0 mIU/mL REF 1.5 - 12.4
Luteinizing Hormone (LH), serum 5.5 mIU/mL REF 1.7 - 8.6
Estradiol (E2), serum 24.4 pg/mL REF 11.3 - 43.2
Testosterone, Total 3.33 ng/mL REF 2.49 - 8.36
Testosterone, Free 6.2 pg/mL REF 5.4 - 40
SHBG (Sex Hormone Binding 28.6 nmol/L REF 18.3 - 54.1
Globulin)

30 Male. 185lbs, 5'7. Maintaining 15-17% BF. Have been consistently working out (4-5x per week) for the past 12 years. Over the past 4 years, I have seen a significant decline in my general mood, energy levels and overall performance (both in the gym and in regular life). No PED's. Standard otc supplements and vitamins- Multi vitamins, D, Zinc, B12, Magnesium, Creatine, Whey etc.
Muscle and strength gains have plateaued. Have really hard time moving past my status quo. While putting on size and getting stronger is still important to me, energy and drive are my biggest concerns.
Decided to finally get my blood tests done.
Test levels back in 2020 (my earliest blood test to date) were:
Total Test- 538 ng/dL with Ref range of 249-836.
Free Test- 120 pg/mL with Ref range of 47-244.
​
Things started to really feel worse in 2023. Did tests in the beginning, middle and end of the year.
January 2023
Total test- 446ng/dL with Ref range of 250-1100
Free Test- 70.9 pg/mL with Ref range of 35-155
SHGB- 23 nmol/L with Ref range of 10-50.
June 2023
Total Test- 355ng/dL (dont have ref range on this one)
December 2023
Total Test- 300ng/dL with Ref range of 250-827.
Really wishing I had more consistent tests performed with same lab and same panels but different doctors etc made different test orders.
​
Was out of the country for the month of January 2024 and figured I'd get my start of year test done as it was cheap and wanted to look at other things in my panel as well. Need help understanding what I should be looking at and focusing on. At this point I'm at my wits end. I get it, as we get older levels will start to fall off, but seems like my body decided to take a dump as soon as I hit 30. Nothing in my lifestyle has changed from what it was 4 years ago. Stopped taking Adderall roughly 2 years ago. Not sure if that will play much of a role.
My diets and caloric intake has been good (roughly 3k maintenance calories, 2500 for summer cuts), workout routines and consistency have been as it was for the past decade. I'd like to say my knowledge and understanding of working out and dieting is relatively good as I've been doing it for 12 years and have helped and coached many people to get in shape. While I'm happy about the progress I've helped others achieve, I am damn pissed off at my lack of progress.
While TRT appears to be a viable solution, I would very much rater exhaust all potential options/remedies naturally and attempt to address the potential underlying issue in my physiology. If I can find a way to have my body get back to optimal levels via its own mechanism, that would be preferred. Tired of doctors saying you're low but you're fine.
With that being said, can someone help me understand what levels on this test below appear to be good vs not good. Some of the numbers are different than what I am used to.
Thank you all in advance!
​
T3, Free 3.47 pg/mL REF 2.0 - 4.4
T4, Free 1.13 ng/dL REF 0.89 - 1.76
Thyroid Stimulating Hormone (TSH) 0.93 μIU/mL REF 0.27 - 4.20
Follicle-Stimulating Hormone 3.0 mIU/mL REF 1.5 - 12.4
Luteinizing Hormone (LH), serum 5.5 mIU/mL REF 1.7 - 8.6
Estradiol (E2), serum 24.4 pg/mL REF 11.3 - 43.2
Testosterone, Total 3.33 ng/mL REF 2.49 - 8.36
Testosterone, Free 6.2 pg/mL REF 5.4 - 40
SHBG (Sex Hormone Binding 28.6 nmol/L REF 18.3 - 54.1
Globulin)

I am 54 and have a wonderful family doctor who unfortunately has never discussed menopause with me past running labs and saying that yes, I am menopausal. The reason I asked them is that I had a uterine ablation and my tubes tied about seven years ago so without lab levels I would have no idea. I have always had anxiety, and started anxiety medication during COVID-19. I recently started Strattera at a very low dose to address brain fog after unsuccessful trials of both Adderall and Vyvanse. I have gained 25 lbs since perimenopause. Again, I think I have always been ADHD but it has gotten unmanageable. Although I love my doctor it makes me angry that I have been pulling my own research from PubMed and that HRT has never been discussed as an option.
I recently decided to go talk to my OB about HRT only to find that effective January she no longer accepts my insurance. If I were not a therapist, I would struggle to have the knowledge base or tools to advocate for myself. I can’t even get an appointment with a new provider until April and I’m miserable. I got online Friday and researched a range of online menopause providers and landed on Evernow. I can’t say enough good things, the WHNP talked me through options and I just picked up my Progesterone 100 and Estradiol .5. With insurance it cost me 11.00 and there was no attempt to upsell me anything.
All of this is to say that I’m overwhelmed. I’m the first among my friends. I am back to yoga multiple days a week and doing the WW program and just want to feel more like myself. An older wiser version is fine. Anyone care to send an atta girl or a success story my way?

(22f) 5’6 ~230lb. Daily norgestimate-estradiol, 100mg lamotragine, 40mg adderall. I have been very itchy the past week or so. Mostly on my stomach and back, but sometimes my legs and arms too. There is no rash. I, for the life of me, cannot figure out why. I have new stretch marks, which are horizontal, unlike the vertical ones I got when I recovered from an eating disorder 4 years ago. If I were gaining weight I wouldn’t question them, but I am participating in dry January and have been so busy the last month or so that I forget to eat from time to time and am eating less, so if anything I am probably losing weight (although per the whole eating disorder recovery, I do not weigh myself unless I am at a doctor’s office). I had a yeast infection last week due to being put onto antibiotics after being bit by a rat at work (i work in preclinical oncology research, this was an immunocompromised barrier facility rat, no risk of infection). I took 150mg of Fluconazole for the yeast infection, but only after the itch started. Ive been applying unscented lubriderm lotion 2-3x a day and its not helping. I’ve had no clothing, medication, or detergent changes leading up to the itching. I have not traveled recently. Other medical history: I was born with 1 kidney and a didephys uterus. Any ideas?

Background: ~50 years old. Went through chemo and radiation for lymphoma in chest 20 years ago. Never did much strength exercises but was big on endurance sports from 2005-2018 or so - a few marathons, a 50k, three full Ironman triathlons, etc. I was definitely fatter than the typical folks in those events.
When I started working from home during the pandemic, I lost all motivation to stay in shape, packed on 35-40 pounds, and have been on antidepressants and Adderall for the past three years, eventually getting a diagnosis of bipolar ii and new medication back in November, and things started picking up; however, energy and libido were still low. My psych and I both suspected low t could be a factor, but my PCP would only put me in for a half assed total testosterone lab, which came back in range but on the low end.
I ended up taking things into my own hand, and using references from here, I ordered a set of labs of my own that were eventually processed by Quest.
The key results came in Monday: Testosterone- Total ms: 162 ng/dL Free: 28.1 ng/dL Bioavailable: 57.9 ng/dL
Nothing else terribly exciting. Cholesterol is a little high and has been improving. HS CRP came back a bit high at 4.4. DHT and estradiol are in the teens, FSH (3.3) and LH (1.6) are at the tail end of the typical range.
I took that info to my insurance's website and started looking for urologists with strong hormone replacement practices. I set up an appt with a PA and had Quest forward over the labs. After hearing my medical history, current symptoms (basically the full low t bullet point list minus lack of beard growth), and reviewing those numbers, I was pretty much given my choice of options on trt along with the pros/cons of each: clomid, cream, injection, pellets, and quickly settled on injections with pellets considered once I'm on a stable dose that works for me.
Prescription was called in for 200mg injected once weekly. I stuck myself about an hour ago, and now we wait. Follow up labs and visit with the urologist are scheduled for April. Should I bother trying to get them checked any sooner?
Besides the standard diet and exercise advice, which I'm hoping will be easier to follow when my hormones aren't all out of wack, any advice is welcome, especially on the topics of avoiding testicle atrophy/shrinkage and hair loss.

Background: ~50 years old. Went through chemo and radiation for lymphoma in chest 20 years ago. Never did much strength exercises but was big on endurance sports from 2005-2018 or so - a few marathons, a 50k, three full Ironman triathlons, etc. I was definitely fatter than the typical folks in those events.
When I started working from home during the pandemic, I lost all motivation to stay in shape, packed on 35-40 pounds, and have been on antidepressants and Adderall for the past three years, eventually getting a diagnosis of bipolar ii and new medication back in November, and things started picking up; however, energy and libido were still low. My psych and I both suspected low t could be a factor, but my PCP would only put me in for a half assed total testosterone lab, which came back in range but on the low end.
I ended up taking things into my own hand, and using references from here, I ordered a set of labs of my own that were eventually processed by Quest.
The key results came in Monday: Testosterone- Total ms: 162 ng/dL Free: 28.1 ng/dL Bioavailable: 57.9 ng/dL
Nothing else terribly exciting. Cholesterol is a little high and has been improving. HS CRP came back a bit high at 4.4. DHT and estradiol are in the teens, FSH (3.3) and LH (1.6) are at the tail end of the typical range.
I took that info to my insurance's website and started looking for urologists with strong hormone replacement practices. I set up an appt with a PA and had Quest forward over the labs. After hearing my medical history, current symptoms (basically the full low t bullet point list minus lack of beard growth), and reviewing those numbers, I was pretty much given my choice of options on trt along with the pros/cons of each: clomid, cream, injection, pellets, and quickly settled on injections with pellets considered once I'm on a stable dose that works for me.
Prescription was called in for 200mg injected once weekly. I stuck myself about an hour ago, and now we wait. Follow up labs and visit with the urologist are scheduled for April. Should I bother trying to get them checked any sooner?
Besides the standard diet and exercise advice, which I'm hoping will be easier to follow when my hormones aren't all out of wack, any advice is welcome, especially on the topics of avoiding testicle atrophy/shrinkage and hair loss.