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I've seen a lot of people ask about any positive experiences with Q. here's a detailed post from a year ago from my previous account with one of those automated usernames
OP: https://www.reddit.com/qelbree/comments/13ej5ck/qelbree_diary_woo/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button
[copy pasted here too]
Yes, I am writing this at 4am bc of qelbree insomnia
context: 30F, combined type ADHD + bipolar 2. currently on a gap year career wise in the medical field, which made it easier to deal with side effects. Have tried adderall (increased irritability, barely helped with focus, stopped after a month). Ritalin, guanfacine, clonidine, and strattera did nothing, but I also had no side effects.
slowly titrated up because I'm pretty sensitive to new medications. On 400mg and moving to 500mg today, the positives are definitely worth it. Waited until the side effects calmed down before titrating up each time. also switching mood stabilizers throughout this ordeal.
Update: on day 4 of 500mg and just really angry, so staying on 400mg
-dry mouth finally significantly better 4 months later (june) -insomnia still sucks, started taking Doxepin for sleep due to potential interactions with other medications I take. Started at 10mg (less than starting dose), moved up to 20 pretty quick, and now that's starting to not be very effective unless im deadddd tired so will probably move to 30 sometime soon.
Qelbree 100mg/ February:

• so much nausea. Dear God. wish I knew to take it with meals!
• dehydration even though I drink so much water??

- gatorade is your best friend.

• insomnia wasn't much of an issue
• fatigue lasted about 2 weeks? exhausting but you'll get through it
• increased irritability the first 2 weeks

-loss of appetite
200mg/ March

• increased irritability for 10-14 days after increasing dose. clonidine and guanfacine are used for kids, mostly for impulsivity and hyperactive kids, and they're preferred over stimulants for them. no studies of it showing changes in adults. psych said don't bother adding it but i've read it helps some people on here. didn't help me when i gave it a go 5 years ago
• insomnia kicked in mid-March. awake roughly 2-7am. Even if I took 10mg melatonin vs 5mg it had the same effect.
• didn;t see much of an improvement, like maybe 10%
• no more nausea, fatigue, but dry mouth started.

- yes libido increased too lol
-loss of appetite continues, lost 10lb in total. Had to look up eating/food strategies people on stimulants use because I was getting lightheaded from eating very little from not recognizing hunger cues
300mg/ April

• increased irritability for 10-14 days after increasing dose.
• insomnia still kicking my butt. I wake up exactly 2 hours after falling asleep, generally 2:30-7:30am I'm awake. and so focused it's so strange. I sleep maybe 5 hours daily? previously would've never survived on that.
• vivid dreams started
• dry mouth still an issue- tried xylitol mints which help for a bit

- learned to always eat Qelbree with food! high protein/low fat encouraged. don't think my dr knows this

• seeing real improvement, excited for 400mg

400mg/ April 28- May 10

• increased irritability for 3-5 days after increasing dose, but went away really quickly
• the vivid dreams are to the point where sometimes idk if I'm sleeping or awake
• insomnia has started to calm down after 2 weeks of 400mg and split dosing. Initially still got up 2 hours after going to sleep, but now I sometimes get a solid 4-5 hours of sleep and it is life changing
• dry mouth is intense. I use biotene toothpaste, doesn't help much. Xylitol mints are a quick fix. the biotene mouthwash does actually work for a few hours! dunno how you'd incorporate that into your work day though without being noticeable :/

- split dosing: 200mg at 10:30am and 200mg anytime between 2pm-6pm. with food. Has helped, still tweaking it

• iMPROVEMENTS ARE NOTICEABLE!!!! easier to start tasks, switch from one task to another, feeling more motivated after months of burnout and the qelbree irritability + insomnia package. It's only been a week or two but man the last few months of side effects were worth it. I feel like my brain is possibly functioning to the potential it has.

i can prioritize things properly for the first time in my life. it's actually mind blowing.

• sometimes the go go go/running on a motor energy has me thinking maybe this is anxiety increasing? Sort of having a hard time "relaxing" between tasks but ive never really known how to relax without losing All focus so idk
• tea/coffee normally makes me sleepy, recently tea has been making me even sleepier and the new studies about qelbree and caffeine metabolism are worth looking into

I'll be moving to 500mg today (the highest my psych has prescribed, said 600mg is only if your weight is ++) mostly because I want to get all the side effects out of the way before starting work again. A lot of my job requires Maximum Executive Function which i obvs don't have, so this medication has given me hope that I won't be eaten up (again) for messing up patient lists and missing orders. I also want to up to 500mg in order to deal with the stress and insane ADHD challenges of my job, so hopefully this works out. Hopefully insomnia, vivid dreams, and dry mouth go away??
TLDR lots of side effects for months but totally worth it because my brain doesn't feel so broken woo. Hope this helps someone!
1 year 3 months after starting qelbree the difference is night and day, I can actually function and DO THINGS without being 500% exhausted.
-Still on 400mg. Take it at night (w/o food even!) bc I get this weird reaction if I have caffeine within ~45mins of taking it. I get dizzy and fall asleep immediately for half an hour, but caffeine in general makes me sleepy and Q apparently exaggerates the effect it has on you. So checks out.
-side effects: dry mouth isn't bad, just use the mouthwash in the morning. insomnia still there, have to take doxepin 30mg or can't sleep. I eat less, probs I'm using less brain power on small things.

As an Australian who still loves JW - the day being I picked up a box of 'perc 20's (in Australia we dont call them percs, oxynorm is the good stuff) and randomly JW came on the radio and the lyric 'I take prescriptions to make me feel a-okay' made an instant connection and I've combed over thousands of his songs. I'm 2 year clean for anyone who cares.
I wonder how much Juice WRLD was taking towards the end. I am NOT 'neg raving' as we call it here or big noting my drug use, but I was taking up to 400mg of oxy at a time and I was functioning fine. I know in the Juice docu not long before his passing he put 4 30s in his mouth - 120 is a 'high dose' for some - but if hes been taking 2-3 percs consisently then his body would of accustomed to it quick. But from previous experience, once you got 4 at a time, it can snowball REALLY quick to the 200mg period - next thing its 250, 300mg and then somehow trying to afford 400mg.
My question is - what his usage during his worst, in terms of highest dosages? And is it confirmed how many he took on the plane? I am just curious if this was a standard dose or if he was still in the low 100 range and he 12 30's or something then I can understand.
I was also curious if he ever did try heroin for music. In PITR - that definately sounds like someone on heroin and not just higher oxy. I believe thats truely his vocals on heroin - you can hear that husky heroin noise in his vocals (I liked it)
I also never understood why he drunk lean - you are taking OXY mate, codeine is SHIT after you graduate to oxy, it converts to morphine in the body I guess so I guess in a way your taking OXY + Morphine - but surely he wouldnt of felt it. Oxy is stronger than morphine. If he was doing it for the promethazine, then go buy phernergen that shits everywhere.
Cheers fellas

I want to preface this by saying that I was probably the only person (or almost only as I've met maybe 1 or 2 other people on Reddit) who claimed flares from CoQ10. It actually flared me quite a lot — sometimes I could handle 100mg and sometimes even 30mg would lead to terrible pain. It was frightening to be one of the rarest cases in a pool of already rare cases, so, naturally, I tracked reactions to supplements extremely attentively (u/vadroqvertical won’t let me lie about that) and I have tried a lot (my cupboard is full of supplements — I spent around €3,500 on them in the span of 1.5 years). I will list reactions to supplements and the approximate timeline of when it happened:
— First of all, CoQ10/Ubiquinol flared me not so much 1 month out (tried 100mg ubiquinol multiple times) but it got worse as time went on to the point that April 2023 I could not even take 30mg without great pain. I tried it 1, 2, 3, 4, 5, 6, 8, 16 months out all without luck with varying doses flaring me to different extents. I will outline the reasons for it below;
— Vitamin E flared me a lot 2, 4, 6 and 8 months out. Never tried again. Tried 200-400 IU at a time. Due to poor GSH regeneration through Glutathione Reductase dependent upon B2 and NADPH;
— Benfothiamine flared me as well (doses 150mg-300mg/day). This is due to high sulphite and blockage of complex IV of the Electron Transport Chain in the mitochondria the reason for I will explain further. Thiamine is easily broken down by sulphite in the body and it is broken down into sulphite as well, which causes a negative loop reaction in people with high sulphite levels. Benfothiamine also caused me a severe allergic reaction (extreme anxiety and itching) that gladly did not require hospitalisation but was extremely scary and scarred me psychologically (likely high sulfocysteine activated NMDA receptors);
— Vitamin B6 increased my neuropathy when I got it. Likely due to poor B2 functional status. The problem I was also deficient in B6 and its supplementation led to great improvements in sleep quality once I could tolerate it. Note B6 is easily destroyed by sulphite just like B1;
— Riboflavin flared me (tried at 100mg, doses under 10mg never flared me). This is likely due to unmatched NADPH supply due to high sulphite load in the body (speculative);
— Astaxanthin greatly improved my physical health at 5-6 months out (proving that the core of my issues was solely ROS) but it caused reductive stress (NADH accumulation), which also caused pain, albeit the pain was a different kind and asta caused worsening neuropathy and visual snow. It accumulates in fat tissue, so stopping it was nice with ROS coming to a balance at about 10-12 days after discontinuation (after a loading dose of 36mg/daily for 3.5 weeks) but ROS then came back after it went out of the body further. I did not retry astaxanthin as I realised it caused me reductive stress and neurological issues;
— NAC helped me a damn lot. It was the best antioxidant for me. The problem is it depleted my molybdenum and copper and started giving me allergic reactions (low molybdenum + copper as well as blocked complex IV will lead to way higher sulphite generated from NAC);
— Did not feel much from vitamin D. I live in a very sunny country and tested at 51 (ref. Range 30+) without any supplements;
— Magnesium helped me a lot. #1 supplement;
— Calcium did not help me much in the beginning, actually, caused me heart palpitations. Was fine taking it after a few months;
— Potassium was a good supplement. I took 800mg/day for a while and it supported my muscle health;
— Important: vitamin B5 made me feel a lot better. It took my ROS down like crazy — I could feel normal muscles again, it removed my oxalate pain completely, too but for only a short while like 3-4h.
I have tried many more supplements that were phyto-supplements and such and none of them really helped me beside maybe some placebo effects. Some made me feel worse and were not worth it at all. I did not try anything mood-changing as I was not interested in it. To note, GABA supplement made me feel a little euphoric at first.

Hello, everyone! It's been a while since I posted anything or even visited the sub. I do not visit the sub anymore as I collected all the information I needed long ago and staying on the sub only led to more thinking about flox. Focusing on other areas of life has been a great life hack for me! I have done a lot of positive things in the past half a year - I am starting my own business, been meeting new people and making a lot of new friends. Flox has changed me for the better.
I want to preface this by saying that I was probably the only person (or almost only as I've met maybe 1 or 2 other people on Reddit) who claimed flares from CoQ10. It actually flared me quite a lot — sometimes I could handle 100mg and sometimes even 30mg would lead to terrible pain. It was frightening to be one of the rarest cases in a pool of already rare cases, so, naturally, I tracked reactions to supplements extremely attentively (u/vadroqvertical won’t let me lie about that) and I have tried a lot (my cupboard is full of supplements — I spent around €3,500 on them in the span of 1.5 years). I will list reactions to supplements and the approximate timeline of when it happened:
— First of all, CoQ10/Ubiquinol flared me not so much 1 month out (tried 100mg ubiquinol multiple times) but it got worse as time went on to the point that April 2023 I could not even take 30mg without great pain. I tried it 1, 2, 3, 4, 5, 6, 8, 16 months out all without luck with varying doses flaring me to different extents. I will outline the reasons for it below;
— Vitamin E flared me a lot 2, 4, 6 and 8 months out. Never tried again. Tried 200-400 IU at a time. Due to poor GSH regeneration through Glutathione Reductase dependent upon B2 and NADPH;
— Benfothiamine flared me as well (doses 150mg-300mg/day). This is due to high sulphite and blockage of complex IV of the Electron Transport Chain in the mitochondria the reason for I will explain further. Thiamine is easily broken down by sulphite in the body and it is broken down into sulphite as well, which causes a negative loop reaction in people with high sulphite levels. Benfothiamine also caused me a severe allergic reaction (extreme anxiety and itching) that gladly did not require hospitalisation but was extremely scary and scarred me psychologically (likely high sulfocysteine activated NMDA receptors);
— Vitamin B6 increased my neuropathy when I got it. Likely due to poor B2 functional status. The problem I was also deficient in B6 and its supplementation led to great improvements in sleep quality once I could tolerate it. Note B6 is easily destroyed by sulphite just like B1;
— Riboflavin flared me (tried at 100mg, doses under 10mg never flared me). This is likely due to unmatched NADPH supply due to high sulphite load in the body (speculative);
— Astaxanthin greatly improved my physical health at 5-6 months out (proving that the core of my issues was solely ROS) but it caused reductive stress (NADH accumulation), which also caused pain, albeit the pain was a different kind and asta caused worsening neuropathy and visual snow. It accumulates in fat tissue, so stopping it was nice with ROS coming to a balance at about 10-12 days after discontinuation (after a loading dose of 36mg/daily for 3.5 weeks) but ROS then came back after it went out of the body further. I did not retry astaxanthin as I realised it caused me reductive stress and neurological issues;
— NAC helped me a damn lot. It was the best antioxidant for me. The problem is it depleted my molybdenum and copper and started giving me allergic reactions (low molybdenum + copper as well as blocked complex IV will lead to way higher sulphite generated from NAC);
— Did not feel much from vitamin D. I live in a very sunny country and tested at 51 (ref. Range 30+) without any supplements;
— Magnesium helped me a lot. #1 supplement;
— Calcium did not help me much in the beginning, actually, caused me heart palpitations. Was fine taking it after a few months;
— Potassium was a good supplement. I took 800mg/day for a while and it supported my muscle health;
— Important: vitamin B5 made me feel a lot better. It took my ROS down like crazy — I could feel normal muscles again, it removed my oxalate pain completely, too but for only a short while like 3-4h.
I have tried many more supplements that were phyto-supplements and such and none of them really helped me beside maybe some placebo effects. Some made me feel worse and were not worth it at all. I did not try anything mood-changing as I was not interested in it. To note, GABA supplement made me feel a little euphoric at first.
It is very relevant that I have been oxalate dumping since 27 Dec. 2023. The description of the experience can be found here: https://www.reddit.com/floxies/comments/1by0uh0/comment/kyma718/
Now, to the real question: why did CoQ10 flare me even at high nutrient status (just after flox). I have to stress that flares from CoQ10 were much less at the beginning of flox likely due to better nutrient status (it went from extremely terrible to slightly more extremely terrible while 6 months out it went from ‘eh’ to terrible).

1. First, I have to say that NAC made me worse long-term. How? Over a long period of time I was taking it and was not watching my copper levels (NAC increases metallothionein and causes poor copper absorption) and molybdenum levels (NAC raises generation of sulfite and it needs molybdenum to be detoxified). Some NAC formulations have molybdenum in them but I was not lucky to get one of those and, due to lack of knowledge, did not supplement any molybdenum. The result was high sulphite and from that high ROS (with a combo of benfo which further increased sulphite it caused me peripheral neuropathy at 5 months). Sulphite causes Fenton reactions when complex IV gets blocked up. H2S (a signalling molecule and a vasodilator) also needs to be detoxified by a CoQ-10 dependent enzyme and turned later into sulphite and then sulphate by molybdenum and complex IV (dependent on copper) and if it is not detoxified, it causes a complex IV blockage and starts Fenton reactions as well as electron leakage during production of ATP, causing ROS. This causes a negative feedback loop that was described in the linked article as follows:

«This can be explained as follows:
1) hydrogen sulfide inhibition of complex IV generates superoxide in the respiratory chain, which becomes hydrogen peroxide,
2) hydrogen sulfide reduces ferric iron to ferrous iron, which makes it release from storage in ferritin,
3) this increases Fenton reactions between free iron and hydrogen peroxide, which generate more dangerous reactive oxygen species like the hydroxyl radical,
4) all of this deplete glutathione,
5) since a major purpose of the trans-sulfuration pathway is to provide enough cysteine to make glutathione, glutathione depletion hyperactivates the trans-sulfuration pathway, leading to more cysteine availability, the excess of which is catabolized to sulfite by alternative reactions that do not produce hydrogen sulfide and therefore do not require CoQ10.»

1. In the article linked below, you will see that CoQ-10 protects against reactive oxygen species mainly due to improving hydrogen sulphide clearance (H2S). Therefore, CoQ-10 deficiency did not cause much ROS in complexes I and II but mainly produced issues in Complex III (where sulphite detoxification starts) and complex IV (where the last electrons are delivered during the sulphite-sulphate reaction). Excerpt: «In human cells with CoQ10 synthesis defects from the same study, CoQ10 protected against reactive oxygen species, but suppressing the enzyme that uses CoQ10 to clear hydrogen sulfide abolished this effect. This shows that the reactive oxygen species were coming from poor hydrogen sulfide clearance.»

Considering this, and oh my god, finding this article was like god sent it to me: my CoQ10 flares were coming from poor hydrogen sulphide clearance. At that point there were multiple reasons this could be happening:

1. Cellular CoQ-10 deficiency;
   
2. Manganese toxicity;
   
3. Copper deficiency;
   
4. Molybdenum deficiency;
   
5. SUOX (enzyme which converts sulphite to sulphate) or another genetic impairment;
   
6. Blockage of complex IV by something else.
   

I checked my molybdenum and copper transporting genes, SUOX using DBSNP and my AncestryDNA.txt file, and they were all good (Yes, I know Ancestry does not do a full genomic profile but it still had the main SNPs for that.). I also checked my manganese transporter genes and seemed I was homozygous for an important one but fine with others. It is really hard to estimate how that might affect you IRL, perhaps that would require a real genetic counsellor (or lots of hours spent ruminating again). I also did not think I had any genetic issue since I was very very healthy all my life and had 0 pain or health issues before flox occurred (I have extremely healthy young looking parents that drink, smoke and do whatever they want and have 0 consequences to their health as well).
I took some tests, for example: Genova NutrEval at ~6 months out, full nutrient blood test panel at ~11 months out (abstained for 35 days from any supplements at all, even vitamins and tested literally everything, paid around €1,200) and my CoQ10 levels at both of those occurrences were at 1 & 1.07 in absence of supplementation with ref. Range 0.8-1.4, so it was definitely not low. That way I eliminated #1 and #5. While I was not entirely sure whether genetic issues had to do anything with it, I decided to pretend like they didn’t, since I had to try out other solutions before jumping to the most complex one. I took a lot of molybdenum, so molybdenum deficiency was not at the table for me. In this way I was left with #2, #3 and #6. In the full blood panel, my manganese was slightly high (20.1 with ref. Range <~18) and the SNP people were talking about that caused them manganese toxicity was homozygous for me, so I definitely considered it but manganese when supplemented made me a feel a lot better, actually (mentally, not physically), so I was also likely deficient in it. For now, I just avoid it in supplemental doses but I do not avoid foods containing it. Besides, I do not have iron overload genes that could contribute to manganese toxicity.
I could not take copper because it would lead to high ROS immediately (due to complex IV blockage the reasons for which I will outline further). Considering manganese was likely deficient and not superfluous, I discarded reason #2 and reason #3 could not be fixed by copper, so it was definitely not only copper deficiency but either another factor or another factor coupled with copper deficiency. I was stuck for a long time until I found another article from the same author about B12 and B9 helping to detoxify oxalate. As I said before all this explanation, I have been oxalate dumping throughout the whole process (already 4 months). I should note I was oxalate dumping even before I got floxed (I likely had oxalate overload to my appendix surgery — this is proven by inflamed mesenteric lymph nodes confirmed by 3 MRIs — Sally Norton has the same case of over-absorption in her book) and that is how I actually got the E. Coli they gave me Cipro for (oxalate crystals create a good environment for it in the urinary tract lol) and how I got floxed (I went full circle, lmao). When I was floxed, I was not oxalate dumping for at least a year likely because my body was not in the state to handle the dumping process but it was still affecting me as I will outline further. First of all, I want to say that biotin actually promoted dumping for me as said in the article and not relieved it like it is said in Sally Norton’s book (I am not sure if there is a genetic variation to this). The proposed mechanism of oxalate detoxification in the article is as follows:
«Recall my proposed two-step detoxification process:

1. Pyruvate carboxylase [biotin-dependent] converts oxalate to formate.
   
2. Formate is joined to tetrahydrofolate to enter the methylation cycle, be used for the synthesis of purines or DNA, or be converted to carbon dioxide and exhaled in the breath.»
   

This are also very important words: «There may be more regulation layered on top of this to prevent excessive formate accumulation. It would certainly be preferable to have oxalate crystals cause pain or disrupt the skin than to have formate accumulate beyond the capacity to clear it.» This is why I felt best when dumping. Could eat anything, drink beer, even smoked weed once without issue. Another time though I got too brave, smoked a lot of weed and got a very bad ‘relapse’ but recovered quickly from it. The next morning when using a towel after a shower I had the same pain I used to have 2.5 months out from Cipro (which was extremely bad and took me back 14 months in memories) while before I smoked weed that second time I had almost 0 tendon pain in my daily life apart from oxalate [Here I thought maybe I and DrHungry share similar issues then? He also had an extreme (same in intensity relatively to his flox journey) flare from weed and is also using a lot of sulphur-based antioxidants still. Could such weed flares be related to complex IV dysfunction and/or impaired sulphite clearance?]. In either case, I felt best when dumping, probably because my body was able to regulate formate accumulation and ROS production greatly reduced at those times.
I was sitting outside with my parents and their friends, researching my flox issue when I read these lines: «Formate accumulation is the principle mechanism of methanol toxicity. Part of its toxicity is driven by inhibiting cytochrome oxidase, complex IV of the mitochondrial respiratory chain, which would inhibit the clearance of sulfite and hydrogen sulfide and block the production of ATP.» It finally clicked. It was honestly one of the best moments in my life when I realised. I made the connection between great improvement from B5, formate accumulation, issues with copper supplementation, general ROS improvement and oxalate everything together. Suddenly, my whole flox journey became crystal clear to me.
B5 is mainly used in the body to create Coenzyme A. An intermediate molecule in the production of CoA is called 4’-phosphopantethine and is used in the enzyme 10-methyltetrahydrofolate dehydrogenase (high formate will pair with THF and form 10-MTHF in the attempt of the body to detoxify formate). This enzyme converts 10-MTHF back to THF and creates NADPH in the process which is used by Glutathione Reductase to regenerate Glutathione. Hence, high-dose B5 led to a lot of those reactions occurring and me feeling a big relief from ROS AND OXALATE, so oxalate is indeed detoxified into formate by biotin-dependent pyruvate carboxylase.
Okay, so theory is very interesting but what is theory if it has no proof? When I read it, I realised I finally cracked my flox but I had to get real proof.
Just a few weeks before this, I drank some wine and got nerve damage (likely from high sulphites in it, again, duh — while this was a terrible experience, it played a role in me getting closer to the solution of my issues). Beer caused me no issues, could drink 10 or more bottles in one sitting, eat a lot of rice with no issue. Before, I had only numb hands and top of feet. After the wine, I had burning up to the knee and burning in palms and behind my shoulders. I got fed up with this, I just decided to methylate the fuck out of my nerves and eat copper not in supplements but from calamari (very high in copper but low in vit A, so no toxicity risk like from liver). At that time, I was dumping and my ROS was not too high. I started consuming around 200g protein per day, eating a lot of copper 3-4mg/day and my nerves really healed a lot. To the point they even became normal after 3-4 days. My vision became brighter, it was absolutely crazy. I was also supplementing 150mg molybdenum/day. After a week of that, though, I started getting ROS back and it was very bad ROS, like almost a year ago when I had low molybdenum and copper from a lot of NAC use. That confirmed my suspicion that my issue was indeed sulphite. Eating almost anything caused ROS for me, dumping stopped since the body had no free reducing agents (NADPH) to support sulphate-producing enzymes (oxalate is transported on sulphate transporters, so it literally could not drive out of the cell because it had no car lol). As you understand, high ROS prevents a lot of enzymes from working and here it causes, as you have probably understood, a negative feedback loop.
So, back to the proof. Since I realised that my issue is probably formate, I just decided to take high-dose B5 again (did not add any high dose B2, B1 or other B vitamins, just took my usual B complex with food). It really helped me a lot, again. I felt almost normal. Then, it caused me some pain but I felt how I was getting better and the next day I took it in the day, then in the evening I ate around 80g carbs and took double the dose of B complex (my B complex has low doses: 10mg B1, 10mg B2, 25mg B3, 20mg B5, 5mg B6, 100mcg B7, 100mcg B9, 50mcg B12) instead of adding a lot of B5 and boom, no pain and oxalate dumping restarted quite more strongly than it even used to be before megadosing protein. So I was in pain for at least 2 weeks dying from ROS and then 2 days of B5 and suddenly I was normal again? It felt like paradise. The next day, I went out with my friends. I was a little nervous since we were going to eat out and we ordered 600g of carbonara (the portions here were huge there). I ate it all at once with 2x my light B complex and guess what happened? NO PAIN, just oxalate dumping. I finally realised that I was right and detoxified formate unloaded my complex IV, allowed sulphate transporters to be created, reduced ROS production from food and suddenly I felt like a normal human being (except the dumping part). I recently retried CoQ10 — no flare. Likely before formate got recreated a lot because I was dumping a lot (if you read my comment, you will understand).
I am not megadosing B5 right now but just stuck to 80-100mg B5 per day, so 4x my light B complex as my B6 tolerance improved a lot. Why I am not megadosing B5 is because oxalate likely blocks conversion of vitamin B2 into its active forms as I at ~11 months out when I did full-testing in the absence of supplementation 35 pre-testing had high molybdenum, iodine, (almost above the ref. Range (113 with ref. Range <120) selenium and very high B2 even though I was cellularly deficient according to Genova NutrEval (at 356 with ref. Range <295).
Hence, we can understand what happened to me from the beginning:

1. Oxalate overload led to formate overload as oxalate is converted to formate through the action of biotin-dependent pyruvate carboxylase;
   
2. Formate overload led to complex IV blockage, high ROS and high sulphite, which also leads to high ROS and also leads to complex IV blockage (negative feedback loop);
   
3. High sulphite destroys vitamins B1&B6 as said in the beginning, which caused endogenous production of oxalate to skyrocket (you can read about this if you google, this information is very available);
   
4. Hence sulphate transporters also got impaired, oxalate detoxification in the form of physical crystals also halted, which led to even higher overload;
   
5. This led to higher formate, this led to even more ROS.
   

Mega-dosing B vitamins and especially B5 and B9 led to formate detoxification and the ability of my body to detoxify oxalate. This improved me a lot and it definitely feels like it will inevitably lead to my recovery. I feel good now, I still have some remaining neuropathy but it’s minimal and I know what to avoid to not make it worse and how to improve it quickly if I need to. I have no OS from beer, coffee or food. Also, I am dumping a lot right now. You can ask me all kinds of questions that you want and I will try to answer them to my best ability since I know what it is like to be floxed and I will help anyone who is in the same situation. I am only 22 years old and this experience led to me rethinking my whole life. I plan to become an extremely rich person to be able to fund biochemical research in the future and will focus specifically on floxed individuals and I will help floxed people first. I will try to reach my goals as fast as possible, I promise.
I hope this post does not get removed by moderators. If there is anything to moderate, change, or add, I will be happy to do that. All I say here is very attentively selected and fact-checked either from external sources or personal experience. I do not lie and have no motivation to do so. I am only trying to share my knowledge and to help realise others flox is not unbeatable and can be understood and solved — it all depends on individual factors.
Linked articles:
Manganese Toxicity Is a CoQ10 Deficiency
https://chrismasterjohnphd.substack.com/p/manganese-toxicity-is-a-coq10-deficiency
CoQ10 Deficiency Is Sulfur Toxicity
https://chrismasterjohnphd.substa2ck.com/p/coq10-deficiency-is-sulfur-toxicity?utm_source=profile&utm_medium=reader
10-Formyltetrahydrofolate dehydrogenase
https://lpi.oregonstate.edu/mic/vitamins/pantothenic-acid#formyltetrahydrofolate-dehydrogenase
Can Biotin Help Detoxify Oxalate?
https://chrismasterjohnphd.substack.com/p/can-biotin-help-detoxify-oxalate
Can B12 and Folate Help Detoxify Oxalate?
https://chrismasterjohnphd.substack.com/p/can-b12-and-folate-help-detoxify

Hi askdocs
I've (36M) been dealing with high blood pressure (150/85+) this year and have made a ton of progress through exercise, diet, and quitting drinking/smoking. Lately, I've switched to having low (below 80/60) blood pressure. It's been low enough that I've almost blacked out from standing up and during weightlifting.
I talked to my doctor already and he's having me lower my Losartan dosage from 100mg daily to 50mg and stopping my hydrochlorothiazide 12.5mg entirely to start, with instructions to continue lowering the dosage until my systolic is back around 120. We currently think I'll be able to stop the medication entirely.
I've also added protein shakes (muscle milk) to my diet to ensure that I'm not malnourished, since my other medications (listed below) suppress my diet significantly.
My question is: at what point should I go back to weightlifting? It's been 3 days on the lower dose and I'm measuring 100/70 before medication and between 90/60 and 100/70 after medication. I'm still getting dizzy when standing up, though not as bad. I was planning on waiting until either I was done adjusting my dosage, or above 110 systolic, but that may be me making excuses for myself.
Medications:

• Venlafaxine 75mg
• Atomoxetine 40mg
• bupropion 150mg
• Aripiprazole 10mg (1/2 a 20mg tab)
• Losartan 50mg
• Gabapentin 300mg (as needed at bedtime for nerve pain)
• Atorvastatin Calcium 20mg
• Trazodone (temporary sleep aid)
• Nicotine gum 2mg/3 hours (as needed for cravings)
• Vitamin D3 5000 IU
• Ibuprofen and acetaminophen as needed for pain

Lifestyle:
Diet is almond milk yogurt w/ granola, and a protein shake for breakfast, raw vegetables for lunch, coldcut sandwich for dinner, fresh fruit, nuts and dried fruit for snacks, 2-3L of water and unsweetened tea for fluids (I've been over hydrated per lab results). 30-60 minutes of exercise on weekdays.
Background:
My weight is currently 215lbs (97.5kg) at 5'11 (180cm). I've been a 1/2 pack/day smoker for 16 years and an alcoholic for 14 years. No indication of liver or kidney damage, and my chest x-ray was clean. I'm currently 3-months sober and have quit smoking, but I'm still using nicotine gum and pouches. I have significant back, ankle/foot, and joint pain from military service and am diagnosed with GAD, MDD, and ADHD (hence the laundry list of medications). My cholesterol was above 300 as of 4 months ago, but is down to 107 as of a week ago. Sleep is a disturbed 5 hours/night.
I've been back in the gym for 3 months, lifting and walking. Outside of exercise, I'm pretty sedentary.

Mid-40s male here. I'm in decent shape, not jacked or anything, but 5'8, 160lbs, able to run 60 minutes at 8 minutes per mile. Resistance train at least 2x a week and can do tons of bodyweight stuff (can knock out up to 70 good form push-ups without stopping, and can do 5 dead hang pullups). Wouldn't mind a little extra edge for lifting/general athletics.
But...I need a little help in the bedroom department sometimes. Everything works, especially when alone, but with a friend sometimes it doesn't STAY working. Not sure I need a full on medical solution yet, so looking for a quick fix stack that could take effect inside of a week (I have...plans...next weekend).
I cycle 300mg ashwaghanda for 2-3 weeks every few months. I also take 30mg of zinc gummies every now and then in addition to the zinc in my multivitamin and protein powder. I'm probably going to try tongkat this week for the first time, too.
Any other suggestions that can give me a quick performance boost, even a minor one?

Age: 5, Sex/Neuter status: Male/neutered Breed: Boston TerrieFrench Bulldog mix, Body weight: 28lbs Clinical signs: Very healthy dog until 3/17/24 when he had a grand mal seizure for nearly 3 minutes. Took him to urgent care and all of his blood tests were normal. The vet thought it perhaps was just a random seizure- no medication was given. 2 days after first seizure, he had a complete personality change, forgot learned tricks and where he lived, started poor coordination (difficulty walking and falling down), heavy breathing with a lot of reverse sneezing, panting, trembling, pacing, and extreme lethargy.
2 days after his first grand mal seizure, I took him to the ER again since he sounded like he had difficulty breathing- along with all his other troubling symptoms listed above. He was prescribed 15mg Codeine every 8 hours for 7 days along with 100mg Gabapentin every 8 hours. 3/21 to 4/6 he continued trembling, shaking, randomly yelping, began circling to the left for 10 minutes at a time, staring at walls, and I would find him in very strange places in the house. After days of continued reverse sneezing, on 4/7 he vomited two large masses of thick mucus. I took him back to the ER. His chest x-ray and all his blood tests were normal. I was told he could be suffering from breed-related Interverbral Disc Disease and he was continued on 100 mg Gabapentin every 8 hours and 15 mg Codeine. None of his symptoms improved- he was very withdrawn, lethargic, and I basically had to put food in his mouth so he would eat. 4/18 in the early morning he had a small seizure, followed by 2 others shortly after. I rushed him to the ER again. The vet said he needs an MRI, but I do not have the money to pay for that and asked if there were any other options. The vet put him on 20mg prednisone every 12 hours and 500mg Levetiracetam every 12 hours. The vet said if my dog didn't respond to the medicine within 3 to 4 days, I would probably need to put him down. After around 4 days, my dog did a complete 180 and began eating and returning to his old self- even remembering some of his old tricks. It was a miracle. However, now, after around 2 weeks on this very heavy dose of prednisone, my vet wanted to start to taper the dose, but when I tried to reduce the prednisone to 30mg a day, he had another seizure after just 1 day doing that. So, I have returned to the 40mg of prednisone a day as advised by the vet to keep all of his symptoms under control. Is this sustainable to do such a high dose of steriods? Obviously my dog has something very wrong with him and I wish I could pay the money to find out what it is through an MRI, but I am already way out of my budget as a teacher and struggling to pay out of pocket for all of the ER visits and meds he has required. Have any of you ever experienced similar symptoms with your Bostons? I am desperate. He is the only thing I love in this world, and it kills me I cannot do more for him.

Species: Dog Age: 5 Sex/Neuter status: Male/neutered Breed: Boston TerrieFrench Bulldog mix Body weight: 28lbs Clinical signs: Very healthy dog until 3/17/24 when he had a grand mal seizure for nearly 3 minutes. Took him to urgent care and all of his blood tests were normal. The vet thought it perhaps was just a random seizure- no medication was given. 2 days after first seizure, he had a complete personality change, forgot learned tricks and where he lived, started poor coordination (difficulty walking and falling down), heavy breathing with a lot of reverse sneezing, panting, trembling, pacing, and extreme lethargy. Your general location: New England
2 days after his first grand mal seizure, I took him to the ER again since he sounded like he had difficulty breathing- along with all his other troubling symptoms listed above. He was prescribed 15mg Codeine every 8 hours for 7 days along with 100mg Gabapentin every 8 hours. 3/21 to 4/6 he continued trembling, shaking, randomly yelping, began circling to the left for 10 minutes at a time, staring at walls, and I would find him in very strange places in the house. After days of continued reverse sneezing, on 4/7 he vomited two large masses of thick mucus. I took him back to the ER. His chest x-ray and all his blood tests were normal. I was told he could be suffering from breed-related Interverbral Disc Disease and he was continued on 100 mg Gabapentin every 8 hours and 15 mg Codeine. None of his symptoms improved- he was very withdrawn, lethargic, and I basically had to put food in his mouth so he would eat. 4/18 in the early morning he had a small seizure, followed by 2 others shortly after. I rushed him to the ER again. The vet said he needs an MRI, but I do not have the money to pay for that and asked if there were any other options. The vet put him on 20mg prednisone every 12 hours and 500mg Levetiracetam every 12 hours. The vet said if my dog didn't respond to the medicine within 3 to 4 days, I would probably need to put him down. After around 4 days, my dog did a complete 180 and began eating and returning to his old self- even remembering some of his old tricks. It was a miracle. However, now, after around 2 weeks on this very heavy dose of prednisone, my vet wanted to start to taper the dose, but when I tried to reduce the prednisone to 30mg a day, he had another seizure after just 1 day doing that. So, I have returned to the 40mg of prednisone a day as advised by the vet to keep all of his symptoms under control. Is this sustainable to do such a high dose of steriods? Obviously my dog has something very wrong with him and I wish I could pay the money to find out what it is through an MRI, but I am already way out of my budget as a teacher and struggling to pay out of pocket for all of the ER visits and meds he has required. Please adivise what I should do? He is the only thinig I love in this world and I wish I could help him more.

Apologies in advance if this is long af and kind of all over the place, I’ve got a lot to say lol
I’ve been taking Adderall for the past 10+ years. I was specifically on 30mg XR for majority of that time. It wasn’t until the shortage within the last 3 years (that I experienced, I know it’s been going on longer) that I started to reevaluate my situation. So at first my doctor moved me down to 20mg XR of Adderall and added on 150mg of Wellbutrin. The Wellbutrin didn’t really do much besides making me very irritated and angry lol. The Adderall drop from 30mg XR to 20mg XR wasn’t bad, but the more I’ve been on this specific dosage now I notice a difference in when I take it and when it wears off. After a few months of the 150mg for Wellbutrin, we moved it up to 300mg to see if that would make a difference. It actually helped and it seemed like it was working really well. However, I ended up getting an allergic reaction to it and had to stop taking Wellbutrin lol. Went back to the doctor and we decided to try Strattera next. We started with 25mg, which I stayed on for a while, but it didn’t do much so we moved it up to 50mg, which is what I am still on now.
I’m not sure if it is really doing much for me at this dosage? Is it hard for anyone else to tell? Like I notice some big things like getting tired midday or not having much focus after a certain period of time, but I feel like that is just the Adderall wearing off. Plus the fact that I was on 30mg XR of Adderall for that long I think it’s just messed my brain up a bit. I really didn’t want to switch from the 30mg XR of Adderall in the beginning b/c it had been working for so long, but b/c of the shortage and the side effects I had developed over all those years, I was over it. I still have issues getting the 20mg XR refilled every month, which is so stressful and frustrating I literally don’t wish it upon anyone to have to go through.
Another big thing I’ve noticed is my appetite. Being on Adderall has suppressed it, but the Strattera does nothing (from what I’ve noticed). I think it could be due to taking 30mgs of Adderall for 10+ years that the Strattera doesn’t do much unless at a high high dose, but I feel like I binge a lot more, which is so upsetting. I’ve always had an issue with it, but the high dosage of Adderall helped a bit to control it. Could also be stress who knows
I’m thinking of bringing the Adderall down to maybe 15 or even 10mg then raising the Strattera to either 80mg or 100mg to see how that will feel? I would love to be off of Adderall, but I’m scared b/c it helps and the withdrawal is not fun. My doctor and I talked about switching to vyvanse, but I wanted to move away from having to take stimulants (eventually) and my insurance doesn’t cover the brand. Does anyone have any suggestions or experiences? I haven’t seen many people on here talking about taking Adderall and Strattera together (could be missing it as well) so hoping there are a few that can provide some insight.
I feel like I’m missing a lot, but I hope someone is able to relate to this in some way as well!

Acabo de entrar a un trabajo como médico laboral y todos los días son compañeros que ocupan receta para sus enfermedades (su seguro médico los cubre). Es deprimente ver recetas así todos los días, carajo.

so i started off taking 1 of them (it was green pradas said to be 300mg) and it felt like it usually does, feeling great like usual then thats when i get the idea to take the rest because i already felt confident on the first one, and i messed up big time because as soon as i took the rest i started to be filled with regret, when they kick in i start to sweat and it starts to have negative effects on me, i didnt feel euphoric like usual but rather i felt neutral and i was hallucinating extremely heavily. To the point where it was almost like i dropped a tab, i started to see my wall warp and melt into rainbow spirals and i saw spiders crawl out of my walls, then i started thinking my friends were in my room when no one was there. Since then, i have started to get noticably more eye floaters and have been feeling depressed for 3 days, im wondering if there might have been something in these and when this depressed feeling will stop.

I'm 1wpo and I'm curious what everyone has for pain management, especially those that aren't taking an opioid. I'm genuinely allergic to codeine. Found that out at 18 month old for a set of stitches. I was prescribed ibuprofen and Tylenol. I also have a script for gabapentin for my MS but don't want to abuse it. I'm also use THC for my MS but don't want to be high all the time. My kids don't need to see mom blitzes outta her mind.
I'll be alright one day and the next I'll have pain. Maybe I didn't take my pills on time or maybe I walked to much thanks to my MS giving me spasticity.
EDIT My dosage for gabapentin is 300mg 2-3 times a day. I typically take that 2 times a day for my MS. I really don't like how dopey I feel when I take it 3 times.

Recently got diagnosed at 23 and started medication in February, and titrated up to current dosage of 30mg dextroamphetamine IR (2 tabs x 3 times a day at roughly 4 hours intervals).
Not totally sure if I'm imaging it but I feel like some of the fidgeting, procrastinating and distractedness is starting to return. I felt like at the start I could sit and listen to what people were saying and start and continue work very happily, but my work, school and socializing has felt like a more concerted effort the last month or so?
Just wanted thoughts if it makes sense to ask my psych at my follow up if increasing my dose? And in everyone's personal experience, how long it took before they found their ideal working dose.
Edit: Just so I cover all grounds, I also concurrently see a psychologist and have been doing so for several years, which in large has been very effective

I've been on 40mg for 3 weeks now. Started in December at 10mg for a week, then up to 20. I think I went up to 30 after a month and stayed there for a bit. The only side effect I had initially was shorter menstrual cycle, nothing major. But now at 40 I'm getting frequent headaches, having trouble sleeping, and pretty majorly decreased libido. The headaches are what's really bothering me. I went for a massage today and it's better but for 5 days in a row I had what felt like a mild migraine. I had a migraine within the first few days of starting it as well. But the 5 day headache was also during my period so I'm hoping that was connected and it'll get better.
I know side effects are supposed to get better over time so I feel like I should ride it out but I'm getting frustrated. I want my libido back. I'm tired of headaches. I'd like to go back to sleeping better, but at least for that I can take a sleeping pill on occasion and get some relief. Nothing has worked for the headaches though.
I'm on 150mg wellbutrin XL. Shortly after starting strattera I tried weaning off it and it messed everything up, the strattera and vyvanse stopped working and I felt like a mess. Restarted wellbutrin and it felt like going back to normal, I was functioning better within days.
If the side effects don't get better I could just go back to 30mg and stay there, I still had benefits at that dose I just felt like it could be doing more. But I'm wondering if anyone has had any improvements in adhd symptoms by upping wellbutrin instead. I was on wellbutrin 300mg XL for almost a year and had zero side effects on it but very minimal, almost no improvement in adhd symptoms but that was without vyvanse or strattera. I know the two meds amplify each other so I'm wondering if upping the wellbutrin could help but without the side effects I'm getting now from strattera.
Had anyone tried this and if so, did it help ?

Proof read, edited, and formatted to hopefully be easy for The Trip Keeper to read on YouTube.
A lil about me: I have a family history of schizophrenia with two people in my family being diagnosed. I think that's why psychedelics hit me like a train. I know I'm one of the folks they say shouldn't tripping but I've already done it and I am not stopping anytime soon. I'm quite the spiritual hippie type. I live for the esoteric, bizarre, and werid side of tripping. I'm also quite experienced with psychedelics and drugs in general having tried alcohol, cigarettes, vapes, kava, Kratom, weed, oxycodone, hydrocodone, percocet, Hospital Morphine, Adderall, Ritalin, Vyvanse, Conserta, Nitrous, Acid, Shrooms, n-BOMEs, Synthetic shrooms, random Acid non n-BOME RCs, Hydroxyzine (only snorted while drunk), Phenibut, Promethazine w/o codeine, blue lotus, and a bunch of random herbs and nootropics.
A little context to story, I had got some liquid Acid dropped on Bottle Caps Candy from a family member we'll call R. R had called me up informing me he had liquid LSD and to bring a chalky candy when I came to pick it up. He dosed the candy in another room when I picked them up. When he brought them back there was a thick layer of liquid struggling to absorb into each hit so we smooshed another piece on top of each one, 3 tabs altogether. He told me each one was an equivalent of 2 to 3 hits of high quality LSD. I also hadn't tripped in 6 months at this point but that's a story for another sub. Though the reason why didn't have much to do with tripping itself nor anything fun like psychosis.
A couple days later I found myself with my bills caught up, a slow night on Doordash so no work, extra money, weed, some cigarettes, and my roommate was out visiting Family. I had showered and ate some Chinese before taking a short nap. When I woke up it was around 9pm, obviously already dark outside. I was in a good mood, had nothing to do, and didn't want to go back to sleep so I slapped an LSD bottle cap on my tongue and went for a walk.
One of the pieces dissolved really quickly, like less than a minute quick, while the other piece took atleast 15 to 20 minutes fully dissolve. I was slightly nervous about tripping the days prior and was even a lil scared before placing it on my tongue; but, that fear was completely annihilated when 5 to 7 minutes in I felt this electric tingle that started in the back of my head go down my spine. I started smiling, feeling super happy, and chilled out when the tingle reached the base of my spine. I thought to myself, "Wow, I can't believe I was scared to trip again, I feel amazing right now!!" I lit a cigarette and enjoyed my walk for awhile until I started coming to the end of a col-de-sac, the street I was on was on a downward slope I think this affected things but the end of the col-de-sac and the houses started stretching super tall and became super thin kind of like a fun house mirror. I was completely mesmerized by it till I was interrupted by this electric beeping that made my skeleton nearly jump out of my skin. I had looked over and saw this gray box with 2 pink lights on it sticking out of the ground and assumed that's where the beeping came from. I then straight sprinted home cause I wasn't sure if it was hallucination or not. I did go back a few days later and couldn't find the box.
After opening my front door the night is hard to remember linearly but I will try my best. I don't have the texts anymore from this night since I got a new phone. Once I got back home, I had to use the bathroom so I went did my business but while washing my hands I looked in the mirror and noticed my pupils are starting to look a lot like bowling balls. It was then, I noticed the reflection of the SpongeBob, Sandy, and Patrick on ketamine meme my roommate printed out and pinned on the wall. Their eyes were dilating more than normal and they were all swaying back and forth. I texted R to tell him I finally tried the acid and it's strong. It's roughly 10:40p.m. by this point, even though it had been 1 hour 40 minutes since dropping it had only felt like 30 or 40 minutes ago at the most. I was about to sit down and do a dab but I got a almost telepathic sense I was about to throw up rather than a physical feeling I was about to. After throwing up I texted R freaking out questioning if it was acid since it's not supposed to make you nauseous. He just told me "too much too fast" "calm down put your phone down and be safe". I didn't put my phone down.
I started finally doing some dabs after 2 or 3 big rips I looked over and saw 2 shadow people. One was a little girl with blonde hair, a yellow sun dress, no face, instead was an empty void. It was as if her head was an empty shell and her face was the hole. The other one was a middle aged man with short blackish gray balding hair dressed in overalls, no shirt, work boots, also no face. The second shadow person looked a lot like one of my deceased uncles. They didn't feel menacing or demonic nor even holy as one would expect an encounter of this type. I got up and walked to my kitchen probably to get water but I got distracted by a third shadow person who was a woman but I didn't get too good of a look before being distracted by my thoughts. I started stretching and thinking to myself, "well atleast the dark isn't so scary anymore compared to being schizophrenic" at the time it did feel very profound aswell as I am now genuinely less scared of the dark. There's also cardboard cut outs of the Elysian Full Haze and Full Contact IPA cans hung up in my kitchen. People were walking in and out of the giant head on the Full Haze poster, I thought they were sacrificing themselves to the massive head. Thought the dude on the Full Contact poster was holding my brain aswell.
I remember it was around this time the body load and vasoconstriction was getting so intense that my arms and legs felt lankier than normal and my jaw felt like it was wired shut. I drank some water and brought a glass back to my room. When I came back the ocean thunderstorm tapestry above bed had the clouds and ocean actually moving with the lightning striking. I have string lights behind that tapestry that wrap around to the conjoining wall. The string lights looked like technicolor rainbow stars forming beautiful constellations. Normally, they are only blue, yellow, green, red and twinkle but during the trip some were changing colors to pink, purple, violet, orange, and more colors that don't exist. While the tapestry was animated, it had no sound. There's a framed painting of a deer in a forest during the sunrise on the same wall. The light in the painting was actually coming through the painting as if it was a window with sunlight shining through. The deer even had his head down grazing when normally he has his head turned towards the viewer of the painting. I layed down and decided to throw on some music. I couldn't decide on a song, I hit skip on Spotify at least 30 times before settling on Pink Floyd's Comfortably Numb, cliche I know, but they're one of my favorite bands and usually seem to find me when things start getting intense on psychedelics. I couldn't actually read anymore so I only knew it was Comfortably Numb by the hook and album art.
As I layed in bed I started stretching out and looking around the room. I finally started to relax a lil and calm down from thinking these were possibly nBOMes. I started to really lose myself in the trip. The slight movement of my air mattress made feel like I was floating on the ocean sea, which gave way to a euphoric sense of oneness and that I am an ocean of pure consciousness. The string lights above my bed were twinkling and reflecting slightly off the ceiling. The reflections were blending with the moving geometry on the ceiling. Next, I looked up at my Pokémon 20th anniversary poster. It was a bunch of black and white silhouettes of starter Pokémon from the first five or six gens with the ones in the middle being colored and shaped like Pikachu's head. Every silhouette was pulsating and almost bubbling.
At one point, I watched this abstract splatter colored tapestry for what felt like two hours, in reality it was probably only 30 or 40 minutes at the most. There were rotating hexagonal and octagonal pillars shooting out of the tapestry between the pillars it appeared to boil, the bursting bubbles had sparks flying off of them.
I can't remember exactly when this happened in the night so might as well stick it here. While hanging out in my bedroom, I got up to do what else but smoke more dabs. I did multiple in a row where I would do the whole ritual and forgot I had done so and follow it up with another. While sitting there, I light a cigarette to pass time and to just smoke more while conserving a lil on the wax. On my second or third cigarette in a row I started thinking to myself out loud that, "Ya know, Family Guy is right!! Vaping does look pretty fucking goofy. My twin flame out there probably thinks vaping looks goofy as fuck!! And smoking might look cool to some bitches but they give you cancer and shorten your life. It's less money for weed and psychedelics. I think after tonight I'm done smoking forever." I chain smoked a few cigarettes.
I think this is when I started hearing voices in my head. I was hearing random YouTubers, friends, celebrities, family members, and other random voices saying random words over over again. I truly thought I was hearing my sleeping neighbors' thoughts. I genuinely believed I had Telepathy. The only words I could make out vividly; however, was The Trip Keeper saying, "Gassid" over over like it was a soundbyte looping. At the time I took this as a sign to do Nitrous with Acid and that there was something spiritual I needed to see/experience from it. I was right, however this wasn't the night I did that combo as I had no nitrous at the time and it's an equally crazy experience but shorter story. I'm planning on posting that experience soon, also DO NOT huff nitrous it actually KILLS your brain cells.
Thoroughly freaking out again about hearing voices. I start frantically texting R, however I can't remember what for though. I even vividly remember asking R what would happen if I took more phrasing it "will things get more colorful or last longer?" He never responded. Since I couldn't read I was using speech to text to text R. I also had got up to pace through the house. Ordinarly, I would've left to go on another walk but I had convinced myself if that I had left again one of my cats would get out of the house and somehow I'd get arrested. I look up from my phone to notice a swirling florescent neon colored vortex of geomtry in the middle of my living room. The vortex started swirling towards me and started to suck the words out of my mouth. I saw the phrase ,"The only words that make sense are the ones I say out loud" get sucked out of my mouth by the vortex in bubble letters that distorted and mixed with geometry. As the bubble letters got closer to center of the vortex they would distort super cartoonishly, individual patterns and a mix of colors appeared over each letter. The vortex itself had a wigwag shape to it. At the time I thought in my head, "Damn this is what Jerry Garcia probably ment by "Steal your face right off your head"". I actually attempted to draw this out later on. See the drawing here if I can get imgur to work. I don't really remember turning the lights on all through my house but I vividly remember all the lights being off when the vortex stole my words. I don't remember how the vortex incident ended just that next all I know is all the lights are on suddenly and I'm walking out of my bedroom. It's probably 3 or 4am at this point cause I started hearing my neighbor cough and going in and out for cigarettes the rest of the night. I had laid my recliner, the voices had stopped but that was replaced with an intense loud buzzing inside of my head. I had my head on one of armrests, legs hanging off the other armrest, chair reclined, facing the wall. I was watching the logo on my clawhammer wall flag drip like white blood. My cats, of which I had 10 at the time, 5 being kittens still nursing, were running back and forth and playing with each other. Below the wall flag is a table with a wooden CD tower, my cats Cinderella and Oreo had jumped on the table at the same time. Completely in sync and as one fluid motion they stood up, turned to look at me, arched their backs, and sat down. Their coats were flowing and Cinderella had extra golden stripes in her fur. They stared deep into my eyes for a long time and were trying to ask me telepathically if I was doing okay. I more or less alternated between laying on the floor and my recliner for the next couple hours.
Every now and then I'd hear my neighbor out front coughing. I was debating whether or not to go talk him and wait for the sun to come up. Normally, I would've put on a show from myself at various points through the night but I had no internet at the time.
As the sun was starting to really come up and I was starting to really come down, I went outside and talked with my neighbor for awhile. Told him about my night, he's actually a little bit of a hippie too. I walked to the gas station to get some food. I felt like a zombie the whole way there and back. The light made my eyes sizzle like bacon on the Texas pavement in the middle of July. It felt like my brain was a steaming bowl of scrambled eggs. My jaw felt like I got my shit rocked by Mike Tyson. I came home, ate my powdered donuts despite only being able to taste it's texture which was low-key wigging me out, and watched either Space Ghost Coast to Coast or The Trip Keeper on my phone till I passed out.
The next morning (afternoon), my dad picked me up and we hung the whole day while I recovered and slowly returned to feeling human again. I bummed a cigarette off my dad and decided while smoking it that it was my last cigarette. I actually quit all nicotine for a month and half after this night. I started back up purely because of a bad (tested real) Acid/Nitrous Trip.
I do wanna add while not using nicotine I had vivid dreams about smoking cigarettes and vaping. Keep posted for the follow up stories about my bad Acid/Nitrous Trip, Smoking Dreams, and Snorting Hydroxyzine with Alcohol cause I bet The Trip Keeper wants to hear that last one.

46F, 175 lbs. History: - diagnosed with ADHD, anxiety, mild depression. On Vyvanse 30mg, bupropion 300mg, escitalopram 10mg. - diagnosed with premature ovarian insufficiency at age 36, on HRT (Estradot 50 and Prometrium 100) for that - had partial thyroidectomy at age 38 due to 4cm oncocytoma (Hurthle cell). - all blood tests including TSH, iron, liver panel, urinalysis normal at last annual physical 5 months ago. - non-smoker, non-drinker (maybe 3 glasses wine per year), no recreational drugs.
I took on a new job last year as I was promised more work-life balance (had done 60-70 hour weeks for years before that). It worked for the first month, but as I’m in a role that’s not easy to fill, I have again been doing 70-hour weeks consistently since November. My life is basically get up, go to work, go home late, grab something quick to eat, finish going through the day’s e-mails, drop into bed, and repeat.
I think I’ve been managing really well, but my eating habits have become horrendous (like, grab a muffin for lunch and dinner with some caffeine inbetween). As I’m so exhausted when I get home, I haven’t been exercising. On average I’ll have 2,000 steps in a day, when normally I’d be sitting at 10,000+. I used to head to the mountains (only an hour away) every Saturday for big elevation and long distance hikes/XC skiing year-round. Now I literally haven’t even been on a walk around the neighborhood since Christmas. Brushing my teeth has become a chore, same for showering, though as soon as I’m in the office I can somehow just go go go.
What concerned me now is that this weekend it feels like I had nothing left in me. Yesterday for lunch and meal prepping I made some chicken, rice and veggies, and just a few fork fulls of that made me nauseous. Everything felt gross. I’ve been holding on to furniture just for some strength when moving around. Last night I felt I needed food so bad, but getting to the kitchen and quickly warming up a prepped meal from early and put together a salad was so daunting that I felt I’d have to crawl to the kitchen. Instead I ordered in a burger with caesar salad and actually managed to eat half of that.
I’ve given up my weekend outings, haven’t seen family and friends in months (except for my dad whom I saw for an hour twice), gave up a hobby (took skating lessons with a coach, but she dropped me as I couldn’t make evening practice 3x a week). I have been speaking with a counselor for three years every 6 weeks as I used to have horrible health anxiety (mom had breast cancer, died of ovarian cancer, had a stroke, both of my parents have had emergency brain surgery within a year of eachother, etc). I don’t have a family of my own, so sometimes feel that maybe work has been an escape or coping mechanism of some sort.
I don’t cry, or feel happiness/sadness - everything is just kinda neutral - but yesterday was different. Almost like my body was telling me I can’t keep living like this. Rational me can see how this is abusing my body, and I know I need to do better (statistics aren’t in my favor either - we have BRCA1 in the family, and the generics clinic who went through generations of family history indicated that about 90% of the women on my mom’s side of the family passed away from ovarian cancer and/or breast cancer around age 52-53). I tested negative and do not have that specific mutation (duplication of exon 13, 6kb). But I digress.
So apart from this complete exhaustion this past weekend, I have also noticed quite significant hair loss. I understand that it’s normal to lose ~80 hairs a day, but I get quite full hair brushes, plus lots of shedding on clothes. It seems all concentrated in one big path in the top of my head. My hairdresser also commented on this. I do not use any harsh hair products or color my hair (last time I had colored my hair was pre-pandemic) and this hair loss really picked up 4-5 months ago.
So, does this sound like it’s only stress? Or could this be something hormonal? I had seen an endocrinologist (years ago now) who referred me back to my family doctor (I’m in Canada) to manage my HRT. From what I have been reading, those of us with POI need higher doses, but have never had my doctor agree to that. I do have extreme vaginal dryness and literally zero libido these last 7-8 years.
Would really appreciate any insight.

Hello,
So last night I went out with friends and had drinks (2 shots, 2 cocktails) and didn’t get to take my lithium until around 3:30-4am. I read if it’s been 6 hours since your normal time to just take the missed dose so I went ahead and took it even though I normally do around 10-11pm.
Well I also have an AM dose (300mg ER tabs) and took that around 1pm the next day. This was a good 6-7 hours apart but now I’m worried if I take my regular dose as normal at 10pm I’m going to have too much lithium in my system. I don’t want to miss a dose necessarily because I’m scared of feeling sad or off/depressed if I do.
Would it be best to continue as normal and take my dose tonight as normal or skip it? That would technically be 900mg in 18 hours vs my normal 600mg for the day. I don’t want to mess around with lithium toxicity either.

Almost all the Codeine you can get in many countries has 8mg of Codeine, 30mg of Caffeine, and 500mg paracetamol, which would probably give you a heart attack If you preformed a CWE and consume it without removing the Caffeine in them.
I recently came up with an extremely easy tek that should remove more than 90% of the Caffeine and not lose any Codeine in the process.
General info about the solubility of both compounds before starting the extraction.
Solubility of Caffeine in room temperature water is 2170 mg/ 100ml where as in 0c water is only 600 mg/ 100ml.
Solubility of Codeine in room temperature water is 1000 mg/ 0.7 ml of water only!
Step 1: preform a regular CWE as if there is no Caffeine at all.
Step 2: take your end solution containing the Codeine and Caffeine and measure the total volume of your solution. For example, let's say your total volume was at 50 ml.
Step 3: Pour your solution into a Pyrex plate or any long plate to expose as much of the water as possible to begin the evaporation process. You can place a fan to speed up the evaporation process, or you could place your solution in a dehydrator like how i do it.
You should aim to reduce the total volume of water by at least 50%, but obviously the less water there is, the less caffeine will be in your final solution.
Step 4: after evaporating the solution by 50% at least, place your solution again in the freezer to begin the precipitation process. MAKE SURE YOU DO NOT FREEZE THE SOLUTION TO A SOLID. GET IT AS COLD AS POSSIBLE WITHOUT IT FREEZING COMPLETELY. this is very important as we want to precipitate the Caffeine out of the solution.
Edit: you can also shake or agitate the solution every 30 minutes to make the process faster.
After some time, you will notice that your solution has turned very milky looking, this is the Caffeine being precipitated from your solution. (If the solution is still clear give it more time as sometimes Caffeine will precipitate slower depending on your total volume)
Step 5: take your solution and quickly filter it out using a 20cc syringe with a paper filter towel placed at the bottom. Slowly push the syringe and watch it drip, if the filtered water looks clear. You have removed most of the Caffeine from your solution and now your product is safe to consume. Alternatively, you could filter it out using a coffee filter and a cup. But I wouldn't recommend it.

21M No current ongoing medical conditions.
Meds - Fexofenadine 120mg daily for allergies. Paracetamol 1g 4x/day & Ibuprofen 400mg 3x/day (increased to 600mg if needed) as required for pain, with the occasional use of 2.32% Voltarol instead of Brufen. Omeprazole 20-40mg as required.
Hi all, sorry to be a pain, but I was just wondering if anyone might have any advice as what to do as I'm a bit lost with regards to next steps.
Basically back in December (2023) I slipped and fell at a party and injured my ankle. Immediately following the injury I had an almighty sharp pain shoot up my entire leg, but was able to stand (albeit with a little pain - though this significantly worsened as the night went on). Pain worsened as the ankle swelled up, and once I'd sobered up I could no longer mobilise/weight bare on the ankle. My foot was also numb with the only sensation being pins and needles, as well as being colder than usual to the touch from the point of injury downwards, with pain also shooting up to my knee and sometimes higher (the numbness and colder than usual temperature resolved itself after 1-2 weeks, and the shooting pain going up the leg resolved after 2-3 weeks. The swelling did go down as well but there's still a sort of lump/swelling next to the lateral malleolus).
I tried self care for the first two days afterwards, initially taking Paracetamol (swapped after 1 day to Co-codamol 2x 8/500mg) & Brufen for the pain. This failed and I ended up going to hospital and was sent home without an x-ray and told to "walk it off". Few days later I saw my GP/PCP and was sent to hospital for an outpatient x-ray which had no obvious fractures, and ultimately had a diagnosis of a couple of torn/snapped ligaments & tendons, and was referred for physiotherapy and given a short term prescription for Codeine 15-30mg 3x/day.
That was back in late Decembeearly January. I've been doing my physio as prescribed and using Paracetamol and Ibuprofen as required ever since but I still struggle with pain and the lateral malleolus area still appears and feels a bit lower, larger and slightly further forward than it was before and in comparison to the other side (if that makes sense, I did try capturing it on camera but its not as cleaobvious as it is in-person). The area around the lateral malleolus is also kinda weird to touch and palpate in comparison to the other side.
Admittedly I've been putting it off as I thought it would've improved by now, but now that its been around 20 weeks without a full recovery I'm just wondering what would be the best course of action to take.