Warning of prednisone

Hi all, still working on officially getting diagnosed. I had an appointment with a new neurologist (waiting to get in with a neurosurgeon at the Cleveland Clinic) and got blood tests yesterday.
Leaving the hospital, I was t-boned directly on my door by someone going about 50mph. The side airbags went off, and I have some minor burns and bruises but I got checked at the ER and they did CTs and didn’t find any acute issues.
I know that car accidents can worsen Chiari (and I’ve already been having horrendous symptoms before the accident). I guess I’m just posting to see if anyone has had a similar experience, and/or what kind of things to look for as a warning sign?
I saw my PCP today and I’m on prednisone along with flexeril and gabapentin, plus imitrex for the migraines.
Thank you all in advance!

TL;DR - I’m experiencing constant skin sensations that seem neurological (among other symptoms), but no answers from Neuro. I’m mentally exhausted, scared, and lost.
Firstly, thank you for taking the time to read this. I’m a 32F. Diagnosed with anxiety and IBS-D in 2013; no other known health problems.
In May of 2023 I experienced a week of extreme nausea, so much so that Zofran was a necessity every day (used prn for IBS). At the time I thought maybe I could be possibly be pregnant, so I wasn’t terribly concerned.
At the tail end of that week I was traveling to Colorado with a friend and on our first night there I woke up out of sleep feeling like my body was covered in icy-hot. I immediately started to panic because it was painful, but thought maybe I was overheated or had slept funny. Nausea washed over me again and I ran to the bathroom thinking I would be sick. I was in the bathroom for the next two hours on the floor with my skin burning and vibrating (like I was holding a leaf blower) with such intense nausea that I could barely move. When I started to experience pain in my mid chest and whole body tremors, I had my friend take me to the ER. I was there for 3 hours, given stronger nausea meds and they sent me on my way. I spent the next 5 days of our trip nauseous and intensely fatigued.
I saw my PCP as soon as I could, but by that time I had developed a “burning” sensation on areas of my face, scalp, hands, arms, and back. These sensations come and go very quickly, only lasting a few seconds each time but happening every few minutes. Sometimes they sting, sometimes they vibrate. The feeling seems to “bloom” onto my skin before disappearing anywhere from 5-30 seconds later.
My PCP said she thought I had MS after Lyme, B12, and celiac tests came back normal. She sent me to Neuro. Neuro gave me a brain MRI and a cervical MRI with and without contrast - both came back normal. I did a nerve conduction test (the most painful thing I’ve ever experienced!) and that was normal too. She sent me away and told me to follow up in 6 months.
I’ve been experiencing these symptoms (burning, tingling, fatigue) daily ever since. Its starting on new parts of my body. It’s becoming more painful. It’s so distracting that I have moments where it stops me in my tracks.
It’s killing my mental health. I do have preexisting anxiety and my newest PCP says it’s all in my head and that this is a physical manifestation. I just can’t bring myself to believe that.. I am on Zoloft and feel like my anxiety is under control - it’s even helped my IBS symptoms.
Some significant things I’ve noticed:

• I have frequent headaches, but they don’t reach migraine levels of discomfort. Sometimes medicine doesn’t relieve them, though
  
• I have a section on my lower-mid back that is incredible painful when pressure is applied, but doesn’t hurt otherwise. Been to ortho and PT, nothing is wrong. I can’t lay on any hard surface without intense pain.
  
• When I have been prescribed prednisone in the past, my doctor has warned me that it might make me feel terrible but to finish the dose. However, I have found that it makes me feel AMAZING. Like I can do anything and I wish I could have it as a regular prescription.
  

All of this to say, I feel like no one is taking me seriously. I feel like something could be getting worse and I’m without any guidance. I feel like all the sudden I don’t know myself at all if my doctor doesn’t think I can trust my own brain.
I’m struggling to get through some days. I am going through my first ever depressive episode and I feel like I would do anything to relieve this. Please, am I just crazy? I can’t keep doing this. I’m open to any advice, suggestions, or kind words.

My senior Peke, Twinkie, is around 10 years old now. She's been on phenobarbital for a little over 2 months to control idiopathic epilepsy. Well, I swear, I have a totally different dog now!
For the most part, she seems happier, more active and playful. But it almost seems like the pheno "reactivated" an old spinal injury (7+ years ago) that left her partially paralyzed temporarily - she could walk and potty just fine, but she had no feeling or reaction to stimuli to her rear paws (the vet said her being mobile was involuntary or subconscious, or out of instinct or habit?). She was on crate rest for 6 weeks and on prednisone, rimadyl and dasuquin advanced, and after all that, she was back to normal. And now, she's very wobbly in the rear end, clumsy, and when playing with a toy will throw it around and sort of pivot on her butt to turn to get it, so she's using her whole front of her body, but barely any of her butt or back legs. She walks, runs, jumps and potties just fine, though, so it doesn't seem to be a problem. Her labs and liver levels 3 weeks after starting the pheno were normal. Anyways...
Here's the weird stuff:

1. She has never been a dog to get into trouble or find mischief. She plays with her toys nicely and never breaks or rips them. All of sudden, Twinkie is a naughty pants! Yesterday, she found one of my adult kid's dirty socks, and I caught her chewing on it! She let me take it and put it up without a problem. But today, she found another sock, and did NOT want to give it up. Out of fear of getting bitten, my kid used my grabber tool to try to take it, and Twinkie went after it! What the heck? It's like she was invoking my first Peke, Lily, whose favorite "toys" were my late husband's dirty socks!!! I've never seen another dog do that in the last 15 years! Lily never guarded them in a nasty way, but in a teasing way. She wouldn't even play with toys, JUST the socks! Also, since starting this medication, Twinkie has been copying my kid's Pomsky (who we got October 2022) and shredding Kleenex! I know dogs learn things from other dogs, but for Twinkie, it's JUST the naughty things.. and vice versa, Maple (the Pomsky) has learned to guard things from Twinkie.
2. Twinkie has gotten SUPER whiny, annoyingly so, since beginning phenobarbital. She whines when she's nesting, whines whilst asleep, whines for no apparent reason, but the worst is the whining in the morning! It's like her internal clock is way out of whack. She normally eats breakfast between 10 and 11am (it used to be 9 - 9:30 until these issues started), and dinner at 8:30. Well, now she thinks if the sun is up, and someone got up to use the bathroom, it's time for breakfast, and if it's around 7pm, she demands dinner. The mornings are the worst - the sun starts coming up around 5am, and she'll start whining and yipping LOUDLY anytime between 6am and whenever I feed her. The earliest I'll feed her is 10:30am, the latest 11am. Dinner is the same, except she starts around 7pm, and I feed her earliest at 8:30pm, the latest is 9pm. I'm being strict about the schedule, because she's been so disruptive to me & my adult kids - one who is disabled with ASD + mental health diagnoses, the other who works 2 jobs and also has mental health diagnoses - that we're all exhausted and struggling to perform our daily duties. I've begun putting her on a leash at the first whine of the morning and night, and keeping her close to me, which seems to help, but I still have to get up early to do it... which leaves me needing a nap midday! I'd keep her in my bed overnight, but for a 10 lb dog, she takes up a LOT of space on my bed! She insists on laying the wide way and will push me to the very edge of my bed, which interrupts my sleep. So, for now, the leash is helping the other 2 humans get their necessary sleep at least.
3. She's been "corncobbing" the Pomsky when they're playing. I don't know if corncobbing is the same kind of thing as "pibble nibbles", but Twinkie is doing that when she's NEVER done it before. You know where they just use the front of their teeth and take tiny little bites in a row? My second oldest daughter has a Boxer Pit mix that corncobs, but I've never seen another dog do it aside from her. Twinkie just started the corncobbing and also play biting the Pomsky about 2 weeks ago. She does it on her butt, legs, and neck.
4. She's been just sitting outside in the rain during her potty breaks, and she has always hated rain! Up until a week ago, if it was raining, she'd walk the edge of the house under the eaves to go potty, and come right back in afterwards. Some rainy days she just skips pooping altogether, she hates it that much! Oddly, she likes snow! But that's just weird for her, to just sit on the sidewalk, getting rained on and not wanting to come in, even with treat bribes.
5. She's not more cranky than usual - she's always been a crotchety old hag of a dog - but she's been more bitey than normal, and picks fights with the Pomsky and is always warning the Boxer mix. If she's in a bad mood (which has always been a LOT of the time), if another dog gets within 8 feet of her or her things - her things include everything in the room, including me - she's growling, baring teeth and lunging at them.

I've been calling her my "drunken munchkin", because she's been so weird and not making sense in my mind. Sometimes she's a playful puppy like she's never been since I've had her (around 2 years), and other times she's a vicious rabid beastie! She's always been a quirky little thing, scared of hiccups and gum chewing and dolls, hates being baby talked or having her space invaded (including stranger's hands coming at her for pets) and hates kids, but only if they're moving (walking, running, jumping). She loves kids when they're infants in car seats or rockers, or sleeping toddlers and kids... she'll kiss them and snuggle up with them. She seems to hate certain people or dogs, but then when they rough house together, she wants to defend them? Wacky! She loves people the most of they completely ignore her and pretend she doesn't exist. If a person ignores her like that, she'll climb into their lap and make herself at home, but as soon as they're talking or touching or even making eye contact sometimes, she's growling and/or showing teeth.
Anyways, I've added a video of her and the sock plus pics for funsies. She's such a sweet, innocent looking demon dog! SHE seems to think she's a Rottweiler, and is fearless (for the most part). She's just a little weirdo, and I wish I could understand her. That's my one issue with rescues, is you never truly know what their previous life was like. Clearly she has trauma. She had a broken rib at some point, and it healed sticking out. But I love her so much, and she is the first dog I've had that has been loyal to me... I'm her person. All our previous dogs and rescues bonded to my husband... he was an animal and kid magnet! So that part is nice. I love that she's independent and doesn't NEED to be on or near me all the time, and doesn't whine when I leave (most of the time). She's very sweet with me, and so she's mine and I'm hers.
https://reddit.com/link/1cugw3v/video/bgsgvufo121d1/player
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I supposedly have MCAS, but is it mastocytosis? Also PSA for people in Portland, Oregon at bottom. A couple months ago I started allergy shots at a local clinic. They hit me extremely hard, like I had a severe flu and all I could do was lay in bed. The doctor upped my ketotifen and Cromolyn to the max and I discovered that Benedryl Extra Strength is ridiculously effective and I started being able to function again, even though I still felt bad. I made it through the lowest tier of doses and then they started injecting me with the next strongest tier and things got really bad. I started having anaphylactic shock responses to basically everything (never had anaphylaxis before that I know of) and sometimes to nothing at all - heart rate going up to 150, almost passing out, extreme vertigo, profound sense of doom, nausea, difficulty breathing, etc. So I stopped the shots about a month ago but the symptoms just kept coming. I started having seizures whenever I eat anything that isn’t rice cakes with almond butter and cheese, and even that I can only eat so much. So that’s basically all I’ve eaten for weeks now, and all I can do is lay in bed to conserve energy so I don’t have to eat much. The only thing that’s made a difference is a different doctor put me on Prednisone, and that’s the only reason I can even eat the rice cakes. And the allergy doc gave me an inhaler which helps with breathing, but makes my heart beat faster too. My blood tests are coming up with low neutrophils, and a low C Compliment, and I have persistently disregulated blood sugar and anemia. I also had a DEXA scan that showed Osteopenia. I also always test positive for lupus on general screenings but negative for it on lupus testing (which the allergy doc ignored when I told her and is just convinced that I have lupus now). Does any of this sound familiar to those of you with Mastocytosis? Have any of you heard of the KIT D816V blood test and know whether it’s worth doing instead of a bone marrow biopsy? Have any of you had bad reactions to allergy shots like this? Was your health permanently worsened? Did anything help? What type of doctors were able to do anything about it? Has anyone had any side effects like this (paradoxical reactions) to Cromolyn or Ketotifen? Does anyone here have any weird mystery immune issues like this lupus thing I’m talking about? Anyone here have seizures in relationship to histamine/food? What helps? I’d also appreciate any suggestions for the lowest histamine foods that have worked for you, because I’m really trying to find other foods that can work out for me. So far it seems like carrots, and weirdly cheese and nuts, and then rice cakes are all I’ve got. Thanks for reading and for the help, I really, REALLY appreciate it.

PSA Time: if any of you are in Portland, Oregon I highly warn you against the Know Allergy Clinic. I genuinely feel they’ve recklessly put my life in danger in so many ways and times, while also treating me with contempt as though I’m making all this up and wasting their much more valuable time. Like at my last doc appointment, when I said “this can’t be normal” the doc said this “happens all the time”, and to see her again in September, while also not being able to tell me why this is happening or what to do about it, or how not to die of starvation or anaphylaxis in the next few months. I don’t even know if I can use an Epipen because they increase your heart rate (which I only found out through Google, not even the allergy clinic) and mine is already so freakishly fast (possibly hypertensive anaphylaxis though), and she wouldn’t help me with that either, despite the fact that they have mini Epipens there that could be safer for me to try in an emergency. And when I said all I could eat is rice cakes to the nurse who asked why I looked ill, she was like “Well, that’s what I like to eat at breakfast and lunch”. 

I’m in extreme need of help. Also PSA for people in Portland, Oregon at bottom. A couple months ago I started allergy shots at a local clinic. They hit me extremely hard, like I had a severe flu and all I could do was lay in bed. The doctor upped my ketotifen and Cromolyn to the max and I discovered that Benedryl Extra Strength is ridiculously effective and I started being able to function again, even though I still felt bad. I made it through the lowest tier of doses and then they started injecting me with the next strongest tier and things got really bad. I started having anaphylactic shock responses to basically everything and sometimes nothing at all - heart rate going up to 150, almost passing out, extreme vertigo, profound sense of doom, nausea, difficulty breathing, etc. So I stopped the shots about a month ago but the symptoms just kept coming. I started having seizures whenever I eat anything that isn’t rice cakes with almond butter and cheese, and even that I can only eat so much. So that’s basically all I’ve eaten for weeks now, and all I can do is lay in bed to conserve energy so I don’t have to eat much. The only thing that’s made a difference is a different doctor put me on Prednisone, and that’s the only reason I can even eat the rice cakes. And the allergy doc gave me an inhaler which helps with breathing, but makes my heart beat faster too. My blood tests are coming up with low neutrophils, and a low C Compliment, and I have persistently disregulated blood sugar and anemia. I also always test positive for lupus on general screenings but negative for it on lupus testing (which the allergy doc ignored when I told her and is just convinced that I have lupus now). Have any of you had bad reactions to allergy shots like this? Was your health/MCAS permanently worsened? Did anything help? What type of doctors were able to do anything about it? Has anyone had any side effects like this (paradoxical reactions) to Cromolyn or Ketotifen? Does anyone here have any weird mystery immune issues like this lupus thing I’m talking about? Anyone here have seizures in relationship to histamine/food? What helps? I’d also appreciate any suggestions for the lowest histamine foods that have worked for you, because I’m really trying to find other foods that can work out for me. So far it seems like carrots, and weirdly cheese and nuts, and then rice cakes are all I’ve got. Thanks for reading and for the help, I really, REALLY appreciate it.

PSA Time: if any of you are in Portland, Oregon I highly warn you against the Know Allergy Clinic. I genuinely feel they’ve recklessly put my life in danger in so many ways and times, while also treating me with contempt as though I’m making all this up and wasting their much more valuable time. Like at my last doc appointment, when I said “this can’t be normal” the doc said this “happens all the time”, and to see her again in September, while also not being able to tell me why this is happening or what to do about it, or how not to die of starvation or anaphylaxis in the next few months. I don’t even know if I can use an Epipen because they increase your heart rate (which I only found out through Google, not even the allergy clinic) and mine is already so freakishly fast (possibly hypertensive anaphylaxis though), and she wouldn’t help me with that either, despite the fact that they have mini Epipens there that could be safer for me to try in an emergency. And when I said all I could eat is rice cakes to the nurse who asked why I looked ill, she was like “Well, that’s what I like to eat at breakfast and lunch”. 

My dog was diagnosed with Non-epitheliotropic cutaneous T cell lymphoma. We started chemotherapy yesterday and he had his first dose of CCNU. He also had a shot of L-asparaginase and Prednisone 20mg 1.5 tablets. The oncology team has done a great job of preparing/informing us about how poor his prognosis is - they told us median survival with chemo is 4-6 months. However, today we've seen a significant reduction in his skin lesions and he seems more perky than he has been the last few weeks. I realize this is likely from the Prednisone but is it possible he's already having a response to the chemo? Is it to soon to hope he'll have an excellent response to chemo? They warned us that his prognosis is based on the lymphomas response to the chemo. He has skin lesions distributed over his entire body but his lymph nodes aren't enlarged and the needle aspirations showed no lymphoma. His blood work was all normal as well. We hope he'll have a good response to chemo and won't be the average for survival but are preparing for the worst and making whatever time he has left the best. They also warned us how lymphoma is unlikely to cause his death but he will eventually be covered in open wounds that will severely impact his quality of life. So at that point we will need to make end-of-life decisions.

Hey y'all, I'm not sure if I'm looking for advice on how to survive the summer or if I need motivation to keep going, or any thoughts on what might be ahead if anyone has any similar experience
I thought I was getting close to figuring it out with my dose in March but at the end of April as it got warmer what I'd been figuring out went out the window. My last crisis and ER visit were in February and since it's been so long some of the symptoms that eased up I'm having again full force and I recognize them as a warning sign
I'm not sure if I should go to the ER yet since I'm not in a crisis right now, but I'm in what I remember the days/week leading up to one feeling like. And it's an awful game of chicken that I can't win either way by having a crisis or not
Brain fog and feeling detached mentally and emotionally, severe fatigue and feeling tired all the time, dull temple headaches, freezing and can't control my body temperature, huge joint and bone pains (my lower right ribs are absolutely screaming as I type this lol) massive shouldeback pain, muscle weakness, insane insomnia despite being worn down or after sleeping 14+ hours, can't eat and haven't felt hungry to even try for days... the usual I think, for what most severe lows in cortisol feel like here (maybe?)
Not sure what changed but here's my dosing; 0.1mg fludrocortisone 6:30am 2.5mg prednisone 6:30am 1.5mg prednisone 2pm 2mg Rayos (delay release pred) 9pm
My endocrinologist wants me to try to stay around 6mg total prednisone including Rayos as best I can to avoid going too over, and said not to double the fludrocortisone for now because we are working out what my labwork is doing
My last labs showed my TSH was extremely low at 0.301 but my T3, T4 and the reverses were normal. He did a Thyroid antibody and it came back normal/negative, so it's impacted by something but unclear why only the TSH ACTH level was 14.2 (normal range said 7.6-64.2) Vitamin E Gamma, K1 and K2 were all low Food allergy panels showed nothing, negative for celiacs
Despite having Primary AI I had a second very high IGF-1 level in a row. First one was 320, this one was 350 (normal range is labeled as 91-300) so he will be doing a second MRI to scan for a pituitary tumor the first one might have missed. If anyone has any familiarity with that labwork or maybe growth hormone issues too?
But... yeah. I did double my pred doses today or I would have been nonfunctional like the last day or two. I feel like I'm barely scraping by on replacing cortisol and the summer isn't helping, fludro had the salt wasting and night sweating under control until this month. Without much else I can do but wait and see both on a crisis and MRI does anyone have any tips on how I might be able to tip it back away from a potential crisis? Or how to survive summer?
Thoughts on anything above always welcome, especially if you had similar experiences before treating something more. Or just how you got through, because 13 months later I'm losing my endurance on surviving this all. especially if what I thought I figured out in March was really that fragile

Trigger warning - brief descriptions of anaphylaxis symptoms
Context: I'm 22F. I have a weird allergy history. Persistent seasonal allergies, I have noticed tree pollen affects me most. I started developing oral allergies as a kid/preteen. I react to most fresh fruits (apples, pears, peaches, plums, cherries, strawberries, blackberries are the worst) and some fresh veggies (carrots, snap peas, cucumbers). I remember having issues with macadamia nut cookies too. These reactions cause swelling and itchiness around my mouth/lips but no respiratory symptoms. I am getting new allergies even now. I reacted to almond milk a few months ago after not having any issues with it before; my throat started tightening and I immediately stopped eating and took an OTC allergy med. After, I got anxious and cut out all almond products. I was prescribed an Epi-Pen in February after telling my PCP. Additionally, I once had a severe reaction to iodine CT contrast (hives, nose and throat itchiness and closing). It can be mitigated by premedication though (if that's relevant).
Now for the current situation: I had two bowls of Honey Nut Cheerios last week - dry. It was definitely careless of me but I had tolerated them fine my whole life (I was high and had the munchies, too). I felt weird partly through the second bowl and decided to check the label. I saw that it contains almond ingredients and prepared for the worst. My lips were swollen, throat was closing and my while mouth felt numb. Not even 10 minutes later I was calling 911 and administering the Epi. I ended up in the ER and had to get more epi while there because the reaction came back. I was put on a course of prednisone and felt bit crappy for a few days but I'm fine now (minus the severe anxiety about it happening again). From everything I'm reading, Honey Nut Cheerios don't contain actual almonds but peach and apricot pits. I have an appointment with an allergist soon because of this but I feel weird about the whole thing now.
TL;DR: Can Honey Nut Cheerios trigger nut allergy anaphylaxis despite not technically containing nuts? Is it possible that it was the oral allergies despite never experiencing a severe reaction from fruits before? Any input is much appreciated. This is taking a big toll on me and I want to be armed with knowledge until my first allergist appointment.

Can I tell you his story? What happened to our beloved boy and caused us to find this community? You don't have to agree with how we handled it, but before criticizing ,please try to understand our love for him. And how hard we (and he) tried to get thru the spinal cord injury. He fought. And that was our rallying cry "IF HE FIGHTS, WE FIGHT." Right now, I need to "talk" with someone, and this community is the only world that truly understands. I can't answer the phone. I can't email. I can't say his name. It's like if I say it, he will be lost to me.
Today we helped our sweet, sweet boy pass over the Rainbow Bridge. Rescued 12 years ago from a deserted canyon road in Hawaii, he will always hold our hearts. It was devastasting. My husband has rarely cried over the past 35 years. When his mom died. When my dad died. Now. Almost five months to the day since our boy suffered a terrible injury at the boarding kennel when his life irreparably changed.
His hind foot caught in the kennel grate overnight sometime between 8 pm and 6 am. He was like that for hours based on the swelling and injury to his foot according to our vet. In trying to free himself, he suffered a severe spinal cord injury from which he never fully recovered.
We picked him up from the emergency vet soon the next day (earliest flight back), and he was paralyzed on all four legs by that time. His crying will forever haunt us. His fear at not being able to move, his pain that riddled his back and neck...it was unbearable. The crying wouldn't stop.
We swiftly moved into action. My husband tended to our injured boy while I worked the phones literally all night calling everywhere in a 200 mile radius fron the DC metro area to find a neurologist and MRI available the next day. Each time I got turned down, I asked "who else can I call?" Word spread overnight in the veterinary community. Just as the sun was coming up and day clinics were getting ready to open, a vet office called our home and said "We heard your story. Can you be here at 10?" Thank God.
The MRI confirmed the injury to the spinal cord. It was bad, especially for a 15 year old dog. But the neurologist and our vet (who specializes in PT), gave us hope. There's a 50/50 chance he can recover, but surgery is not recommended because of his age.
So began the whirlwind of the past months. Diazapam, Prednisone, Gapabentin, so many other meds, I can't remember them all and these changed depending on how he responded. CBD, Senelife, Selegeline (for his terror at being in the dark now) and other joint and healing supplements. Laser therapy, accupuncture, deep tissue massage, exercises, supplements, twice weekly VET/PT appointments, B12 injections, PEMF mat sessions. You name it, we did it. Correction: HE did it.
He made progress. We kept a journal to stay encouraged. Even the vet was cautiiously optimistic but warned he had a long road. And then he started losing ground. He got more tired, less able to stand to eat, needed help again to go to the bathroom. Barely could walk. The vet said his injury was going the wrong direction. He no longer wanted to fight. He was so tired. We made the hard call. The one that hurt us more than anything. We let him go in peace without more suffering.
The sweetest, most grateful dog we have ever known. Run free, little one.

Heya. Long time lurker, rarely post 🫣 History - 52 yo F, 🇦🇺,10 years Medically retired RN/midwife - looooong hx severe osteoarthritis since my 20's, lots of back issues, bulged discs, crush fractures, long term high dose opioids for severe chronic pain, Graves disease 16 years, T2 diabetes in "remission" after 30kg weight loss
6 mths now diagnosed seronegative RA. Fighting w doctors for 10 YEARS as i knew i had something inflammatory going on, even another Rheumy brushed me off (persistent CRP over 15 up to 25+ for over 10 years- range in Aus i think is under 4 ish?) and of course the pain and swelling- hands, feet, knees, shoulders, neck, whole spine.
TOMORROW I'm 5 mths post L4/5 fusion/disc replacement 🥳 (life changer!)
Just completed my 6 mths on Hydroxychloroquine/Prednisone/Celebrex and the horrendous Methotrexate combo. Had a little relief, but not as much as hoped (esp my hands and lately SI joints)
Rheumy started me on Xeljanz last week- 5mg twice a day. Reading side effects scared me a bit! A big warning here in Australia comes up for blood clots so a bit terrified as i lost my mamma 7 years ago at just 61 yo suddenly from a massive Pulmonary embolism 😬😬😬
Who else is on Xeljanz? Any side effects, dramas? I started it on Thursday night last week, have felt fine, no side effects, even- dare I even say this 🫣- i feel like it's already starting to work!?! Is that possible? so quickly? or a placebo effect/in my head lol. My hands and feet (and spine) are worst affected- but for at least 3 days already, my hands aren't as "clawed" and swollen when I wake up 🤷🏼‍♀️ Just curious who takes this also and their experience. Relatively new to RA, I've still got SO much to learn! Need to hang out in here more often 😊 Cheers warriors 🫶🏻

I'm looking for any advice, recommendations or past experiences. My 7 y/o Lab X developed a small pin sized puncture on his abdomen on January 5th, 2024. It wasn't healing well and presented as abcess in February 2024 we did antibiotics and it was getting better until it got so much worse. We opted for surgery on March 30th 2024 due to the growing concern it was a malignant tumor. A biopsy was preformed after removal. Anyone currently experiencing this, please please please do the biopsy before the surgery. It may seem like an unnecessary extra step but if I could go back in time I would. I wasn't warned on any risks of metastasis, he wasn't given any preventative medication. They examined him March 29th and performed the surgery March 30th. I'd like the emphasize the prior to the surgery, despite the 5" tumor, he was a happy and healthy dog.
The day after surgery I noticed small bumps beside his armpit, in the shaved area and outside of it. 5 days later these grew and started to degranulate. I was in contact with the vet and they suggested it may he a trauma wound from the surgery/shave and not to worry about it too much. Despite its degranulation I was given nothing but gabapentin to help manage pain and antibiotics for the incision site. April 6th I was informed it was a high grade 3 mast cell tumor and he had 4-6 months to live. I opted to go for a referral to the onocogist and despite constantly being in contact with the vet due to severity of his new tumors growth, they somehow forgot to send the referral. It wasn't until I asked to know where the referral went that I was told they 'resubmitted the request as urgent".
Throughout the 3 weeks of waiting for the onocologist to call, I went through every corner of the internet and have put Ollie on any supplement that has any positive reviews. Maybe its all snake oil idk.
I put him on benedryl and pepcid, based on Google recommendations which the onocologist has recommended I continue to do.
The onocologist put him on prednisone and we start chemo tomorrow. They said there is 0 hope of treatment and that the chemo/prednisone could be used to reduce symptoms so he can have some quality of life for the weeks/months he has left.
I know there's likley no miracle that will save my baby but I wanted to know if anyone had their dog went through this, if chemo will bring back his quality of life and allow his ulcerated tumor to heal. Or if I'm just prolonging his suffering.
He is truly the purest good boy and I feel so devastated. I'm angry. Why didn't the vet recommend a biopsy first? Why wasn't he given any medication to stop the swelling/degranulation while we waited for the onocologist. Why did the referral get "resubmitted" ( I am well aware this is the professional way to say they forgot to send it). Was this negligence or just purely a mistake? Why didn't they put him on antihistamines prior to surgery if they were concerned about cancer? Why did I pay 3200.00 to make my dog worse based on a vets recommendations?
Maybe I'm just angry, venting, grieving. Any advice or past experiences are appreciated thankyou.

I'm looking for any advice, recommendations or past experiences. My 7 y/o Lab X developed a small pin sized puncture on his abdomen on January 5th, 2024. It wasn't healing well and presented as abcess in February 2024 we did antibiotics and it was getting better until it got so much worse. We opted for surgery on March 30th 2024 due to the growing concern it was a malignant tumor. A biopsy was preformed after removal. Anyone currently experiencing this, please please please do the biopsy before the surgery. It may seem like an unnecessary extra step but if I could go back in time I would. I wasn't warned on any risks of metastasis, he wasn't given any preventative medication. They examined him March 29th and performed the surgery March 30th. I'd like the emphasize the prior to the surgery, despite the 5" tumor, he was a happy and healthy dog.
The day after surgery I noticed small bumps beside his armpit, in the shaved area and outside of it. 5 days later these grew and started to degranulate. I was in contact with the vet and they suggested it may he a trauma wound from the surgery/shave and not to worry about it too much. Despite its degranulation I was given nothing but gabapentin to help manage pain and antibiotics for the incision site. April 6th I was informed it was a high grade 3 mast cell tumor and he had 4-6 months to live. I opted to go for a referral to the onocogist and despite constantly being in contact with the vet due to severity of his new tumors growth, they somehow forgot to send the referral. It wasn't until I asked to know where the referral went that I was told they 'resubmitted the request as urgent".
Throughout the 3 weeks of waiting for the onocologist to call, I went through every corner of the internet and have put Ollie on any supplement that has any positive reviews. Maybe its all snake oil idk.
I put him on benedryl and pepcid, based on Google recommendations which the onocologist has recommended I continue to do.
The onocologist put him on prednisone and we start chemo tomorrow. They said there is 0 hope of treatment and that the chemo/prednisone could be used to reduce symptoms so he can have some quality of life for the weeks/months he has left.
I know there's likley no miracle that will save my baby but I wanted to know if anyone had their dog went through this, if chemo will bring back his quality of life and allow his ulcerated tumor to heal. Or if I'm just prolonging his suffering.
He is truly the purest good boy and I feel so devastated. I'm angry. Why didn't the vet recommend a biopsy first? Why wasn't he given any medication to stop the swelling/degranulation while we waited for the onocologist. Why did the referral get "resubmitted" ( I am well aware this is the professional way to say they forgot to send it). Was this negligence or just purely a mistake? Why didn't they put him on antihistamines prior to surgery if they were concerned about cancer? Why did I pay 3200.00 to make my dog worse based on a vets recommendations?
Maybe I'm just angry, venting, grieving. Any advice or past experiences are appreciated thankyou.

Hello there, I was floxed in August 2023 and finally made a full recovery in 2024. I can pretty much enjoy many of the foods, substances, etc. that I once did again.
I learned something about myself during my floxing period. Even before floxing, I've always had horrible acid reflux. So to fight this I take things like Pepto Bismol. SO nobody ever told me that Pepto Bismol is chunked full of NSAIDS. And there's even a warning online that says "Don't take if you're allergic to NSAIDS." I literally drank Pepto Bismol the entire time I was floxed without any negative effects ! ! !
When I hit this realization, I actually thought it was great news. So does this mean I'm pretty much in the clear to take NSAIDS again ? Because I use to be a regular Aspirin and Aleve user, and I think that's probably way safer for your liver in the long run than stuff like Tylenol is.
The one I'm still not sure about is Steroids. I recently turned down a prescription for Prednisone that a GP tried to give me for sinus issues. I wasn't sure how it would affect me, and I was scared to take it. The thing is, I've had completely separate health problems BEFORE being floxed where steroids played an important role in healing. So while I'm not trying to go out of my way to take steroids, I do feel like they could be beneficial for me in some cases.
Does the Pepto Bisomol thing pretty much mean I'm in the clear to take NSAIDS ? Should I chance steroids again someday ? None of the other stuff floxies warn about seems to affect me. So maybe this is safe too ?

I just need to rant and hopefully get an idea from others on how long they were effected by insulin resistance / unruly blood sugars while taking this med. (everyone is different of course just looking for others experiences)
First time this has happened to me, I broke out in an absurdly painful rash from elbows to knuckles. My hands were scaley, purple, swollen. I tried all the over the counter stuff, there was a prescription steroid topical at home that I gave a go and it was just getting worse and I was in a lot of pain. I went to urgent care a week ago and got a stronger topical steroid ointment and oral steroids, prednisone.
Doctor warned me that my blood sugars would likely be high and stubborn. I never shy away from carbs but with this in mind I have been really staying away from carbs and foods I know will spike me and really pushing liquids, even minimizing my caffeine intake.
The first few days my numbers were fine, I noticed once I did go out of range it was harder to come down but it was still manageable compared to the typical level I experience when getting a cold or the flu.
Now these last three days I have not been able to get out of the 300s if I do it won’t hit the 100s and just sit in the 200s. I have been waking up to correct through the night and nothing seems to help. My pump site is fine it’s not failed. It’s wild though, I have gone through my normal 3 day insulin in cartridge amount in 24 hours. (This is with minimal blouses for food!!! I miss carbs!!!!!)
I got ketone strips to make sure I was okay and I’ll be fine it’s sitting between trace and small. I don’t want to stop the medication thankfully the rash is virtually gone but I know I need to take the full course to ensure it doesn’t come back. Thankfully tomorrow is my last day taking it but I imagine it will be in my system for a while.
I guess I am just hoping to see how long others experienced high levels of insulin resistance after they complete the oral medication?
This was lengthy, thank you if you read all of this!

WARNING: SWOLLEN FOOT PIC AHEAD!
Hi! I have SAI from being on prednisone for a long time. I was put on hydrocortisone march 3rd of this year and it’s been hell. My body has not handled it well. I am immensely swollen. I am on TWO diuretics to help combat this fluid buildup. I can barely sleep I’m so swollen. Will this ever go away?

I thought of creating a throw-away account for this post, but I have thrown all dignity out the window with this disease and all the docs I have seen, so why start now? Warning, if you don't want to read about gross bodily functions, skip this post.
I was DX'd with PsA a little over a year ago. I was on Cimzia for a while then it stopped working. Then Cosentyx, which I failed. I am currently on Taltz and about 4 months in to that treatment. The Taltz has cleared my skin of any psoriasis, but not done much for my PsA, so they also have me on 20 mg of prednisone a day as a bridge, till we figure out what's next with insurance.
However, recently I have noticed sometimes after urination, I will have some leakage. Rather embarrassing for a 46 yo male. I have also been having bouts of what seems like constipation, but it's not like I had rock hard stools. More like the muscles to push are not working as well. It's worse in the morning like most things I deal with, so I am wondering if it's just more PsA? Could it be a side effect of the Taltz or the Prednisone? Anyone else experience anything like this? Thanks!

IMPORTANT SAFETY INFORMATION
CONTRAINDICATIONS
There are no contraindications for LYNPARZA.
WARNINGS AND PRECAUTIONS
Myelodysplastic Syndrome/Acute Myeloid Leukemia (MDS/AML): Occurred in approximately 1.2% of patients with various BRCAm, gBRCAm, HRR gene-mutated or HRD-positive cancers who received LYNPARZA as a single agent or as part of a combination regimen, consistent with the approved indications, and the majority of events had a fatal outcome. The median duration of therapy in patients who developed MDS/AML was approximately 2 years (range: <6 months to >4 years). All of these patients had previous chemotherapy with platinum agents and/or other DNA-damaging agents, including radiotherapy.
In SOLO-1, patients with newly diagnosed advanced BRCAm ovarian cancer, the incidence of MDS/AML was 1.9% (5/260) in patients who received LYNPARZA and 0.8% (1/130) in patients who received placebo based on an updated analysis. In PAOLA-1, of patients with newly diagnosed advanced ovarian cancer with HRD-positive status, the incidence of MDS/AML was 1.6% (4/255) in patients who received LYNPARZA and 2.3% (3/131) in the control arm.
In SOLO-2, patients with BRCAm platinum-sensitive relapsed ovarian cancer, the incidence of MDS/AML was 8% (15/195) in patients who received LYNPARZA and 4% (4/99) in patients who received placebo. The duration of LYNPARZA treatment prior to the diagnosis of MDS/AML ranged from 0.6 years to 4.5 years.
Do not start LYNPARZA until patients have recovered from hematological toxicity caused by previous chemotherapy (≤Grade 1). Monitor complete blood count for cytopenia at baseline and monthly thereafter for clinically significant changes during treatment. For prolonged hematological toxicities, interrupt LYNPARZA and monitor blood count weekly until recovery.
If the levels have not recovered to Grade 1 or less after 4 weeks, refer the patient to a hematologist for further investigations, including bone marrow analysis and blood sample for cytogenetics. Discontinue LYNPARZA if MDS/AML is confirmed.
Pneumonitis: Occurred in 0.8% of patients exposed to LYNPARZA monotherapy, and some cases were fatal. If patients present with new or worsening respiratory symptoms such as dyspnea, cough, and fever, or a radiological abnormality occurs, interrupt LYNPARZA treatment and initiate prompt investigation. Discontinue LYNPARZA if pneumonitis is confirmed and treat patient appropriately.
Venous Thromboembolism (VTE): Including severe or fatal pulmonary embolism (PE) occurred in patients treated with LYNPARZA. In the combined data of two randomized, placebo-controlled clinical studies (PROfound and PROpel) in patients with metastatic castration-resistant prostate cancer (N=1180), VTE occurred in 8% of patients who received LYNPARZA, including pulmonary embolism in 6%. In the control arms, VTE occurred in 2.5%, including pulmonary embolism in 1.5%. Monitor patients for signs and symptoms of venous thrombosis and pulmonary embolism, and treat as medically appropriate, which may include long-term anticoagulation as clinically indicated.
Embryo-Fetal Toxicity: Based on its mechanism of action and findings in animals, LYNPARZA can cause fetal harm. Verify pregnancy status in females of reproductive potential prior to initiating treatment.
Females
Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception during treatment and for 6 months following the last dose.
Males
Advise male patients with female partners of reproductive potential or who are pregnant to use effective contraception during treatment and for 3 months following the last dose of LYNPARZA and to not donate sperm during this time.
ADVERSE REACTIONS—First-Line Maintenance BRCAm Advanced Ovarian Cancer
Most common adverse reactions (Grades 1-4) in ≥10% of patients who received LYNPARZA in the first-line maintenance setting for SOLO-1 were: nausea (77%), fatigue (67%), abdominal pain (45%), vomiting (40%), anemia (38%), diarrhea (37%), constipation (28%), upper respiratory tract infection/influenza/nasopharyngitis/bronchitis (28%), dysgeusia (26%), decreased appetite (20%), dizziness (20%), neutropenia (17%), dyspepsia (17%), dyspnea (15%), leukopenia (13%), urinary tract infection (13%), thrombocytopenia (11%), and stomatitis (11%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA in the first-line maintenance setting for SOLO-1 were: decrease in hemoglobin (87%), increase in mean corpuscular volume (87%), decrease in leukocytes (70%), decrease in lymphocytes (67%), decrease in absolute neutrophil count (51%), decrease in platelets (35%), and increase in serum creatinine (34%).
ADVERSE REACTIONS—First-Line Maintenance Advanced Ovarian Cancer in Combination with Bevacizumab
Most common adverse reactions (Grades 1-4) in ≥10% of patients treated with LYNPARZA/bevacizumab and at a ≥5% frequency compared to placebo/bevacizumab in the first-line maintenance setting for PAOLA-1 were: nausea (53%), fatigue (including asthenia) (53%), anemia (41%), lymphopenia (24%), vomiting (22%), and leukopenia (18%). In addition, the most common adverse reactions (≥10%) for patients receiving LYNPARZA/bevacizumab irrespective of the frequency compared with the placebo/bevacizumab arm were: diarrhea (18%), neutropenia (18%), urinary tract infection (15%), and headache (14%).
In addition, venous thromboembolism occurred more commonly in patients receiving LYNPARZA/bevacizumab (5%) than in those receiving placebo/bevacizumab (1.9%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients for LYNPARZA in combination with bevacizumab in the first-line maintenance setting for PAOLA-1 were: decrease in hemoglobin (79%), decrease in lymphocytes (63%), increase in serum creatinine (61%), decrease in leukocytes (59%), decrease in absolute neutrophil count (35%), and decrease in platelets (35%).
ADVERSE REACTIONS—Maintenance gBRCAm Recurrent Ovarian Cancer
Most common adverse reactions (Grades 1-4) in ≥20% of patients who received LYNPARZA in the maintenance setting for SOLO-2 were: nausea (76%), fatigue (including asthenia) (66%), anemia (44%), vomiting (37%), nasopharyngitis/upper respiratory tract infection (URI)/influenza (36%), diarrhea (33%), arthralgia/myalgia (30%), dysgeusia (27%), headache (26%), decreased appetite (22%), and stomatitis (20%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA in the maintenance setting for SOLO-2 were: increase in mean corpuscular volume (89%), decrease in hemoglobin (83%), decrease in leukocytes (69%), decrease in lymphocytes (67%), decrease in absolute neutrophil count (51%), increase in serum creatinine (44%), and decrease in platelets (42%).
ADVERSE REACTIONS—Adjuvant Treatment of gBRCAm, HER2-Negative, High-Risk Early Breast Cancer
Most common adverse reactions (Grades 1-4) in ≥10% of patients who received LYNPARZA in the adjuvant setting for OlympiA were: nausea (57%), fatigue (including asthenia) (42%), anemia (24%), vomiting (23%), headache (20%), diarrhea (18%), leukopenia (17%), neutropenia (16%), decreased appetite (13%), dysgeusia (12%), dizziness (11%), and stomatitis (10%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA in the adjuvant setting for OlympiA were: decrease in lymphocytes (77%), increase in mean corpuscular volume (67%), decrease in hemoglobin (65%), decrease in leukocytes (64%), and decrease in absolute neutrophil count (39%).
ADVERSE REACTIONS—gBRCAm, HER2-Negative Metastatic Breast Cancer
Most common adverse reactions (Grades 1-4) in ≥20% of patients who received LYNPARZA in the metastatic setting for OlympiAD were: nausea (58%), anemia (40%), fatigue (including asthenia) (37%), vomiting (30%), neutropenia (27%), respiratory tract infection (27%), leukopenia (25%), diarrhea (21%), and headache (20%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA in the metastatic setting for OlympiAD were: decrease in hemoglobin (82%), decrease in lymphocytes (73%), decrease in leukocytes (71%), increase in mean corpuscular volume (71%), decrease in absolute neutrophil count (46%), and decrease in platelets (33%).
ADVERSE REACTIONS—First-Line Maintenance gBRCAm Metastatic Pancreatic Adenocarcinoma
Most common adverse reactions (Grades 1-4) in ≥10% of patients who received LYNPARZA in the first-line maintenance setting for POLO were: fatigue (60%), nausea (45%), abdominal pain (34%), diarrhea (29%), anemia (27%), decreased appetite (25%), constipation (23%), vomiting (20%), back pain (19%), arthralgia (15%), rash (15%), thrombocytopenia (14%), dyspnea (13%), neutropenia (12%), nasopharyngitis (12%), dysgeusia (11%), and stomatitis (10%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA in the first-line maintenance setting for POLO were: increase in serum creatinine (99%), decrease in hemoglobin (86%), increase in mean corpuscular volume (71%), decrease in lymphocytes (61%), decrease in platelets (56%), decrease in leukocytes (50%), and decrease in absolute neutrophil count (25%).
ADVERSE REACTIONS—HRR Gene-mutated Metastatic Castration-Resistant Prostate Cancer
Most common adverse reactions (Grades 1-4) in ≥10% of patients who received LYNPARZA for PROfound were: anemia (46%), fatigue (including asthenia) (41%), nausea (41%), decreased appetite (30%), diarrhea (21%), vomiting (18%), thrombocytopenia (12%), cough (11%), and dyspnea (10%).
Most common laboratory abnormalities (Grades 1-4) in ≥25% of patients who received LYNPARZA for PROfound were: decrease in hemoglobin (98%), decrease in lymphocytes (62%), decrease in leukocytes (53%), and decrease in absolute neutrophil count (34%).
ADVERSE REACTIONS—Metastatic Castration-Resistant Prostate Cancer in Combination with Abiraterone and Prednisone or Prednisolone
Most common adverse reactions (Grades 1-4) in ≥10% of patients who received LYNPARZA/abiraterone with a difference of ≥5% compared to placebo for PROpel were: anemia (48%), fatigue (including asthenia) (38%), nausea (30%), diarrhea (19%), decreased appetite (16%), lymphopenia (14%), dizziness (14%), and abdominal pain (13%).
Most common laboratory abnormalities (Grades 1-4) in ≥20% of patients who received LYNPARZA/abiraterone for PROpel were: decrease in hemoglobin (97%), decrease in lymphocytes (70%), decrease in platelets (23%), and decrease in absolute neutrophil count (23%).
DRUG INTERACTIONS
Anticancer Agents: Clinical studies of LYNPARZA with other myelosuppressive anticancer agents, including DNA-damaging agents, indicate a potentiation and prolongation of myelosuppressive toxicity.
CYP3A Inhibitors: Avoid coadministration of strong or moderate CYP3A inhibitors when using LYNPARZA. If a strong or moderate CYP3A inhibitor must be coadministered, reduce the dose of LYNPARZA. Advise patients to avoid grapefruit, grapefruit juice, Seville oranges, and Seville orange juice during LYNPARZA treatment.
CYP3A Inducers: Avoid coadministration of strong or moderate CYP3A inducers when using LYNPARZA.
USE IN SPECIFIC POPULATIONS
Lactation: No data are available regarding the presence of olaparib in human milk, its effects on the breastfed infant or on milk production. Because of the potential for serious adverse reactions in the breastfed infant, advise a lactating woman not to breastfeed during treatment with LYNPARZA and for 1 month after receiving the final dose.
Pediatric Use: The safety and efficacy of LYNPARZA have not been established in pediatric patients.
Hepatic Impairment: No adjustment to the starting dose is required in patients with mild or moderate hepatic impairment (Child-Pugh classification A and B). There are no data in patients with severe hepatic impairment (Child-Pugh classification C).
Renal Impairment: No dosage modification is recommended in patients with mild renal impairment (CLcr 51-80 mL/min estimated by Cockcroft-Gault). In patients with moderate renal impairment (CLcr 31-50 mL/min), reduce the dose of LYNPARZA to 200 mg twice daily. There are no data in patients with severe renal impairment or end-stage renal disease (CLcr ≤30 mL/min).
INDICATIONS
LYNPARZA is a poly (ADP-ribose) polymerase (PARP) inhibitor indicated:
First-Line Maintenance BRCAm Advanced Ovarian Cancer
For the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA-mutated (gBRCAm or sBRCAm) advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
First-Line Maintenance HRD-Positive Advanced Ovarian Cancer in Combination with Bevacizumab
In combination with bevacizumab for the maintenance treatment of adult patients with advanced epithelial ovarian, fallopian tube or primary peritoneal cancer who are in complete or partial response to first-line platinum-based chemotherapy and whose cancer is associated with homologous recombination deficiency (HRD)-positive status defined by either:

• a deleterious or suspected deleterious BRCA mutation, and/or
• genomic instability

Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
Maintenance BRCA-mutated Recurrent Ovarian Cancer
For the maintenance treatment of adult patients with deleterious or suspected deleterious germline or somatic BRCA-mutated (gBRCAm or sBRCAm) recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer, who are in complete or partial response to platinum-based chemotherapy. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
Adjuvant Treatment of gBRCAm, HER2-Negative, High-Risk Early Breast Cancer
For the adjuvant treatment of adult patients with deleterious or suspected deleterious gBRCAm, human epidermal growth factor receptor 2 (HER2)-negative, high-risk early breast cancer who have been treated with neoadjuvant or adjuvant chemotherapy. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
gBRCAm, HER2-Negative Metastatic Breast Cancer
For the treatment of adult patients with deleterious or suspected deleterious gBRCAm, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer who have been treated with chemotherapy in the neoadjuvant, adjuvant, or metastatic setting. Patients with hormone receptor (HR)-positive breast cancer should have been treated with a prior endocrine therapy or be considered inappropriate for endocrine therapy. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
First-Line Maintenance gBRCAm Metastatic Pancreatic Cancer
For the maintenance treatment of adult patients with deleterious or suspected deleterious gBRCAm metastatic pancreatic adenocarcinoma whose disease has not progressed on at least 16 weeks of a first-line platinum-based chemotherapy regimen. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
HRR Gene-mutated Metastatic Castration-Resistant Prostate Cancer
For the treatment of adult patients with deleterious or suspected deleterious germline or somatic homologous recombination repair (HRR) gene-mutated metastatic castration-resistant prostate cancer (mCRPC) who have progressed following prior treatment with enzalutamide or abiraterone. Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
BRCAm Metastatic Castration-Resistant Prostate Cancer in Combination with Abiraterone and Prednisone or Prednisolone
In combination with abiraterone and prednisone or prednisolone (abi/pred) for the treatment of adult patients with deleterious or suspected deleterious BRCA-mutated (BRCAm) metastatic castration-resistant prostate cancer (mCRPC). Select patients for therapy based on an FDA-approved companion diagnostic for LYNPARZA.
You are encouraged to report negative side effects of AstraZeneca prescription drugs by calling 1-800-236-9933. If you prefer to report these to the FDA, call 1-800-FDA-1088.
LYNPARZA is a registered trademark of the AstraZeneca group of companies.
©2024 AstraZeneca. All rights reserved. US-88021 Last Updated 4/24

Hey y’all. This is more of a vent than anything. It’s my Birthday weekend. I’m only halfway through and in some real pain.
The wife and I had some “alone time” last night and today we took the kids to play mini golf. Nothing crazy for partying like in my younger years. 🥳
I enjoyed every minute of all of that but damn this afternoon I hit a wall. I feel like I have been hit by a bus from just enjoying the simplest things in life. My wrists, elbows, hips, hands and feet are aching with enthesitis. I feel rigid and stiff in the shoulders.
I’m already on a biologic Taltz and failing, so I am also on 20mg of prednisone a day. How the hell can I still be in pain like this? It had been working fairly well as a bridge, not perfect but not this bad.
Does anyone have any tips on any sort of relief or been in a similar boat of being medicated but yet still in pain like this?
I’m not sure what’s next from a medical standpoint and starting to worry more than I have ever. My rheumatologist was thinking Rinvoq but I have a couple cardio issues too. I was really hopeful but It’s got warnings all over it about CV risks of stroke and heart attack. Now I’m not sure. This damn disease and now some of the risks associated with the treatment drive me crazy.
Anyway. If anything thanks for listening 👂

Okay y'all, I'm at a complete loss of what is going on. Have any of you had anything similar happen? For a note, my endocrinologist is aware of the issues and we are pending changes as results of some more bloodwork (listed at the end) but right now anything for advice or sharing your experiences is super appreciated
I know autoimmune disorders and skin issues go pretty hand in hand, but can it extend from dealing with Primary Adrenal Insufficiency (Addisons) into having allergy symptoms or hives?
For a quick reference: I am currently on 4mg of prednisone (but have had to double dose more lately from stress and illness, and now this constantly) and 0.1mg fludrocortisone in the morning and 2mg of Rayos (delayed release prednisone) at night at a 12 hour apart timing -
From March 21st to April 2nd every night at exactly 7:30pm into 8pm without fail I started having intense sudden itchiness. But it doesn't feel like times I would just have dry skin or was dehydrated, and about 4 of those nights I broke out into actual hives. My hair and scalp, my ears and eyes and the corners of my mouth, the back of my neck and chest just started itching and it only felt worse as the night went on
I could only describe it as if for no reason (it happened and came on the exact same time and exact same ways no matter what/if I would eat or when I would eat ahead of time, and nothing I noted as doing even at 3pm was the same to find a pattern or cause) my body was aware of something not good all at once and decided to try and fix it by purging everything but made it worse
When it happens I am also more aware of my legs feeling heavy and tired, joint or almost bone deep pains in my arms, legs and elbows and knees and sometimes in my hands/fingers. Even without hives appearing my fingers would be red and warm and almost tingling. I also get bruises all up my shins and knees and/or cuts on my fingers that weren't present during the day that were then irritated and itchy but would go down and calm like the rest of me with topical lotion and updosing with hydro. If I started breaking out into hives it was just on the back of my neck or around my mouth and it would take adding benadryl on to calm my skin down at all. Luckily I have not had any anaphylaxis or trouble breathing with any of this
Does anyone have any experience with hives or histamine issues with your Addisons? I know it's related somehow to cortisol, or that it happens and then tanks cortisol and that makes it worse because a lot of my low cortiso warning signs (pain, temperature intolerances, increased fatigue and leg achiness/fatigue, hair shedding, and the random bruising and slow to heal/fade cuts) overlap
What is different are the allergy aspects; ears feeling itchy inside and out though I never had ear issues before my diagnosis, intense hair shedding, nose itchiness and coldness, face being itchy and then the hives if it gets that far. Could Addisons or low cortisol almost make your entire body reject itself and be allergic to itself randomly?
If it also helps; we are repeating labwork soon to monitor thyroid because my TSH was extremely low at 0.3 but my T3, T4, and free and reverse were all very normal. We're also monitoring my vitamin k and e levels now because they were deficient and also extremely low. My vitamin D was normal, b12 was high but the key labwork is if I flag on IGF-1 again because my last level was extremely high. We're also now checking for food allergies as a possible cause and any new allergies to wheat and for celiacs markers despite not having had any before and not having allergies to anything but pollen/dust and antibiotics
Sorry for the long post but I am at a legitimate loss on how to process any of this. Since changing my Rayos dose and increasing it from 1mg to 2mg on 4/5 it was seemingly going away and the hives stopped. But the itchiness is back tonight in the exact same areas, so I have no clue what to think

Hi group, just a warning, this will be a long post as I’ve been holding this in and need to let it out. I was recently floxed a month ago from Levaquin that was prescribed with prednisone (FML). A bomb went off on day 3 and this group was the first that came up to confirm I was up a shit creek : ) I have been the lurker, reading endlessly, taking notes and of course started a supplement routine the very day it exploded. Within a week my dr put me on disability for 2 weeks. I could not walk more than a few steps and I was so mentally distraught (I have a husband, 4 kids, 2 dogs, 2 cats, a full time job and have been working out for 20 years and do heavy weight training and 1 day a week, I’d do the stairs for 60 minutes at level 10). I think my mental state was more his motivation to put me on leave. During those 2 weeks, my walking consisted of basic house stuff, ice, magnesium baths, rest/elevation. I also realized full leg compressions helped me walk so they were a must. The last 2 days of my time off were the best days that I gaslit myself into thinking maybe my prior health would help me recover sooner. I started work this Monday. I work from home but my work is incredibly demanding and deadline driven. By noon I realized my feet were the darkest purple/black shade ever so I stopped my day and elevated. My Achilles were very swollen as were my calves, which were crazy tight. Yesterday I’m intentionally getting up more, doing lymphedema stretches, icing and do a makeshift elevation pillow under my desk. I work until about 2p - I’m swollen from feet thru thighs, blood flow to feet ain’t great, and I get a painful swollen bump on my forearm and cramped fingers. Today is pretty much the same. So I guess my question is…are there any good tips on swelling management and like…how the hell am I supposed to pull this off? Also - thank you. This group has been more helpful than any doctor I’ve spoken with. Reddit in general is more helpful than any doctor I’ve met with. Reddit helped me diagnose my husbands inguinal hernia (his surgery is next week) and helped me diagnose my sister with a ganglion cyst when she was worried about a strange bump on her wrist. Ppl on Reddit also helped me tolerate my ADD medication several months back by reading about electrolytes, which immediately took care of the migraines, which was my only side effects.

UPDATE! I posted in the thread with my original post but in case it gets buried wanted to just update here because my derm had a word of warning for using resins! And first off, you guys are an amazing community. Kind, productive Reddit communities are hard to find so thanks to everyone who commented and didn’t roast my pasty ass.
Onto the update: so to clear up timeline of this, I have had this growing reaction since March 30th and we have not been in the house since April 1st. We are not living there until likely next year so for everyone concerned about me still being there I am not! I got an emergency appointment with a dermatologist this morning and they had their colleague come in as well because of how severe the reaction is across my body. This morning my toes on both feet were swollen and covered in rashes, both arms are blistered with the reaction going up my fingers and my butt cheek and quad rash is also significantly larger. The derm is 99.99% sure that this is a wicked case of acute dermatitis from epoxy and says that he is seeing an increasing amount of patients come in with this. He noted that although it’s great they’re seeing more patients he really wishes companies and people who choose to use resins for their own projects would really ramp up their mindset of “rather safe than sorry”. Most are not to this extent but he’s had a fair amount that have been a systemic reaction like mine is and some even worse that have needed very high doses of medication to stifle. He said that they’re finding increasing reactions and that if you’re going to handle any type of resin you need FULL ppe, mask, gloves, proper footwear and long sleeves/pants. He said that even in well ventilated areas he’s had reactions come in, one guy was doing epoxy on his boat which took a couple days to finish and got a full body reaction as well as his entire left leg blistered and rashed up from the knee down. They said for the most part this is something that will settle down with time and to stay away from hot showers and like many said to make sure to really clean the raised rashes as irritants can be stuck in there prolonging it. Due to my specific situation continuing to get worse and the swelling causing numbness they suggested I go on medication such as a prednisone but I’m not trying to gain 30 pounds and have a mental break from that horrible medication. Their other option was rinvoq which used in the short term has less side effects and is used for people with eczema or dermatitis such as this. I am taking the medication even though I generally refuse to take even ibuprofen but after three days of not sleeping and my body getting progressively covered in more rashes and blisters I’m doin it.
Thank you again to everyone who had suggestions, I really just want to use this as somewhat of a PSA that proper handling of resin products is so so important. It’s not worth risking taking yourself out of the game by skimping on protection and then having a reaction that will make it really difficult to keep doing projects in the future.