Example application travel grant
apps_reviews:discover new applications and think about them
2015.03.20 03:30 garnerrr2 apps_reviews:discover new applications and think about them
Under construction
2024.05.22 00:33 Bowazon_ Using Flurry as an attack speed buff with Heartseeker - is it worth it?
 | Hi guys, after seeing Wudi and a few others use Flurry to buff their Heartseeker attack speed, I decided to actually test this out to understand if it's worth doing this. submitted by Bowazon_ to D4Rogue [link] [comments] For context, I wrote the guide on the Heartseeker build and shared it on Reddit and the official D4 discord as well as discussing the build with a few others for some time before then, so I'm very familiar with the build. The Heartseeker guide for season 4 can be read here: https://www.reddit.com/D4Rogue/comments/1crc1ni/season_4_heartseeker_victimise_rogue_guide_by_bowa/ Anyway, this technique of using Flurry to boost attack speed came to be after Blizzard removed attack speed on weapons and significantly nerfed its values in other gear slots. This opened up an opportunity for theorycrafters to find attack speed elsewhere, hence Flurry. But, is it worth it? TestingI ran some frame-by-frame tests for this on the Kyovashad dummy with the following setup and methodology:Setup
ResultsSee below the screengrabs of the results.How to read this data:
Set 2 Set 3 Observations
ConsiderationsAlthough casting Flurry to boost attack speed does net a benefit in the end, some things to keep in mind:
ConclusionIn my opinion, it's not worth using Flurry for its attack speed buff in this way. If you're going to use it at all, it would be:
|
2024.05.22 00:33 The_MadMage_Halaster Looking for Feedback on a Pair of Antagonists.
I just realized that the main antagonist of my campaign (a Lasombra Sabbat priest attempting to take over Santa Cruz) needs a couple of minions that the party can actually face down and reasonably fight, either physically or socially. So I have created two of them: the Shaw Brothers.
They are a pair of identical twins named Benjamin and Timothy, who were born in 1799 to a very religious family in Virginia. Identical through most of their childhood they started to diverge from each other personality wise in their late teenage years, when Benjamin began to chafe under his father's strict and demanding ways.
Eventually, after a spat, Benjamin ran away from home and became a traveling rapscallion who carved a path of hedonism and youthful chaos across the southern half of the Union. He got involved in all manner of things, some criminal some not, and eventually ended up on a riverboat on the Mississippi playing cards with a mysterious stranger late into the night. He was a remarkably good gambler and managed to whittle down his opponent until the stranger had only one thing left to bet, immortality. Benjamin naturally doubted this offer, but seeing as it was both late and night and he had already won so much he decided to humor the stranger. He won that hand too, and was swiftly Embraced into the night by the mysterious stranger.
The stranger was a vampire (obviously) of clan Brujah who took Benjamin to New Orleans, where they got involved in the mess of vampire politics that place was in the early 1800s. Eventually Benjamin grew tired of vampiric politics, and he found his new Sire somehow even more controlling than his father had been. Despite being a Brujah his sire was of the domineering sort who strong-armed anyone who stood against their wishes. Eventually he was able to free himself by using the Capture of New Orleans during the Civil War to trick his sire into going near an ammo depot which he then had an agent detonated Now free from his master he left to find a new group which would grant him the freedom he desired, whereupon he fell in with the Sabbat. Their message greatly resonated with him, particularly the "vampires are better then all the mortals let's rule them" part.
After a few years with them he decided to see what had become of his brother, and so traveled back to Virginia.
During this time Timothy had become a priest, gotten involved in the Second Great Awakening, and eventually got into what amounts to a turf war with a rival pastor. Said rival pastor sent goons after him to beat him up, so when Benjamin found him he was laying injured on his death bed.
Benjamin explained to his brother that he had finally found faith, and he offered to share that new faith with Timothy. Timothy accused him of being a monster against god, which Benjamin didn't deny. He instead offered Timothy first revenge against the pastor who had wounded him, as well as the ability to usher in a new golden age with the return of the Dark Father. He also used a wee bit of Presence as well. Eventually Timothy gave in and was Embraced by his brother. They then killed that pastor and his goons together, and when the Presence and initial bloodlust wore off Timothy bitterly accepted his new state.
Later the two of them joined up under that Lasombra and now serve as his muscle.
Benjamin is a social Brujah, who is also fair in a fight (Presence, Potence). Meanwhile Timothy is much more confrontational, and is a crack shot with firearms who has experience fighting as a member of the Underground Railroad close to the front lines (Clerity, Potence). Benjamin is by far the most dangerous of the two, with him having both half a century and a generation on his elderly brother. He is also a narcissistic sadist who lacks the civility Timothy at least continues to possess. But what he lacks in morals he more than makes up for in charm, clever social manipulation, and a cruel cunning.
Together the two are a dangerous tag-team who will provide a strong challenge for my players.
So, what do all of you think?
P.S. I also made some minis in HeroForge for reference:
https://preview.redd.it/8rbq8gthwu1d1.png?width=1024&format=png&auto=webp&s=dd7d4930160f3ae2004105a71b8c04a19951baec
submitted by The_MadMage_Halaster to vtm [link] [comments]
They are a pair of identical twins named Benjamin and Timothy, who were born in 1799 to a very religious family in Virginia. Identical through most of their childhood they started to diverge from each other personality wise in their late teenage years, when Benjamin began to chafe under his father's strict and demanding ways.
Eventually, after a spat, Benjamin ran away from home and became a traveling rapscallion who carved a path of hedonism and youthful chaos across the southern half of the Union. He got involved in all manner of things, some criminal some not, and eventually ended up on a riverboat on the Mississippi playing cards with a mysterious stranger late into the night. He was a remarkably good gambler and managed to whittle down his opponent until the stranger had only one thing left to bet, immortality. Benjamin naturally doubted this offer, but seeing as it was both late and night and he had already won so much he decided to humor the stranger. He won that hand too, and was swiftly Embraced into the night by the mysterious stranger.
The stranger was a vampire (obviously) of clan Brujah who took Benjamin to New Orleans, where they got involved in the mess of vampire politics that place was in the early 1800s. Eventually Benjamin grew tired of vampiric politics, and he found his new Sire somehow even more controlling than his father had been. Despite being a Brujah his sire was of the domineering sort who strong-armed anyone who stood against their wishes. Eventually he was able to free himself by using the Capture of New Orleans during the Civil War to trick his sire into going near an ammo depot which he then had an agent detonated Now free from his master he left to find a new group which would grant him the freedom he desired, whereupon he fell in with the Sabbat. Their message greatly resonated with him, particularly the "vampires are better then all the mortals let's rule them" part.
After a few years with them he decided to see what had become of his brother, and so traveled back to Virginia.
During this time Timothy had become a priest, gotten involved in the Second Great Awakening, and eventually got into what amounts to a turf war with a rival pastor. Said rival pastor sent goons after him to beat him up, so when Benjamin found him he was laying injured on his death bed.
Benjamin explained to his brother that he had finally found faith, and he offered to share that new faith with Timothy. Timothy accused him of being a monster against god, which Benjamin didn't deny. He instead offered Timothy first revenge against the pastor who had wounded him, as well as the ability to usher in a new golden age with the return of the Dark Father. He also used a wee bit of Presence as well. Eventually Timothy gave in and was Embraced by his brother. They then killed that pastor and his goons together, and when the Presence and initial bloodlust wore off Timothy bitterly accepted his new state.
Later the two of them joined up under that Lasombra and now serve as his muscle.
Benjamin is a social Brujah, who is also fair in a fight (Presence, Potence). Meanwhile Timothy is much more confrontational, and is a crack shot with firearms who has experience fighting as a member of the Underground Railroad close to the front lines (Clerity, Potence). Benjamin is by far the most dangerous of the two, with him having both half a century and a generation on his elderly brother. He is also a narcissistic sadist who lacks the civility Timothy at least continues to possess. But what he lacks in morals he more than makes up for in charm, clever social manipulation, and a cruel cunning.
Together the two are a dangerous tag-team who will provide a strong challenge for my players.
So, what do all of you think?
P.S. I also made some minis in HeroForge for reference:
https://preview.redd.it/8rbq8gthwu1d1.png?width=1024&format=png&auto=webp&s=dd7d4930160f3ae2004105a71b8c04a19951baec
2024.05.22 00:33 Andre3000RPI Yahoo Morning Briefing
Tuesday, May 21 Good morning! Today's Morning Brief is all about strategists revising their 2024 year-end predictions. Nasdaq record highs: The Nasdaq rose 0.65% to a record close as the S&P 500 gained 0.1% Monday. The week's optimism came on the back of a few revised S&P 500 year-end calls (see both today's Takeaway and the Chart of the Day!).
JPMorgan's succession story: JPMorgan CEO Jamie Dimon noted that his retirement was both closer than "five years away," his standard stock answer over the years, and that a succession plan was "well on the way." Talk of the CEO's departure moved the stock down 4.5%, despite the bank's good news: It revised its 2024 revenue expectations higher due to two potential rate cuts. The cuts would increase its net interest margin, a key banking metric marking the difference between what banks pay for deposits and what they make from them. Microsoft's new vision for AI: Microsoft announced its "Copilot+ PCs" on Monday, giving the world a look at how the most valuable company in the world plans to integrate its AI capabilities into consumer computers — capabilities that it hopes will reignite the PC market. Using specialized chips on the devices (no need for cloud processing), the ChatGPT-4o-based system assists users by seeing and analyzing what's already on the screen, integrating a key communication step. The software will be on Surface tablets as well as PCs from the usual suspects: Acer, ASUS, Dell, HP, Lenovo, and Samsung. The stock rose 1.2% Monday. 'A good position to hold steady': Monday's round of Fedspeak had Fed Vice Chair Philip Jefferson and Fed Vice Chair for Supervision Michael Barr concurring with a suite of their peers who have reiterated their wait-and-see approach to rates. One month of encouraging data isn't enough for them, and as Fed Chair Jerome Powell said last week, three months might be better.
Rising metal prices: Gold and copper hit records Monday as silver hit a 12-year high. Gold has been on a roll of late thanks to demand from central banks and potential Fed rate cuts. And copper, as a non-precious metal, has seen its value spike due to higher demand from machinery and wiring applications. Another picks-and-shovels AI trade, perhaps. What we're watching Morning Brief is written and edited by Ethan Wolff-Mann. For the web version, click here. Follow all the action throughout the day on Yahoo Finance and on the Yahoo Finance app.
Taylor Swift's economic boost is traveling from the US to Europe. Amid uncertainty around Social Security, here's what financial advisers are telling clients. Audi furthers EV push into China with new platform agreement. Housing experts revise mortgage rate forecasts for remainder of 2024. Secondhand Rolex sales surge in 'underdeveloped' US market. Wall Street's biggest bear flips, raises S&P 500 price target by 20%. What we're reading
Today's Takeaway is by Myles Udland, Head of News. One of the most notable bears on Wall Street finally flipped this week. Morgan Stanley's Mike Wilson raised his price target for the S&P 500 over the next 12 months to 5,400 from 4,500, a 20% jump amid a market Wilson sees defined by "higher than normal uncertainty." Josh Schafer has more on Wilson's call here. And in his report, Wilson included a chart that serves as a note of caution to stock market bulls looking for lower rates to power the next leg of this rally. "[There] is a wide array of return outcomes across history following the start of the cutting cycle," Wilson wrote. "In many ways, this analysis encapsulates our outlook well — a balanced risk/reward profile in the average/base line view, but the potential for a wide array of scenarios to play out. Once again, get ready for some notable swings in sentiment, positioning and prices."
Interest rate cuts have a complicated history with the stock market The S&P 500's average annual return is around 10%, making the 12-month returns that follow rate cuts, on average, well below this bogey. And with the exceptions of 1974, 1989, and 2019, year-ahead returns for the S&P 500 after rate cuts have typically been well outside this historical average both high and low. All else equal, lower interest rates benefit riskier assets like stocks, bringing down the return hurdle that makes stocks preferable to something like fixed income. What Wilson's data reminds us, however, is that rate cuts aren't something the Federal Reserve typically does "just because." Even the winning years in Wilson's chart are reminders of precarious moments in financial market history — the 1994 bond market crash gave rise to James Carville's famous complaints about "bond vigilantes," and 1998's emerging market crisis and collapse of LTCM forced the Fed to take drastic action to save a single hedge fund.
Go back 18 months and Wall Street expected a recession to prompt rate cuts. Today, the Fed is looking for "greater confidence that inflation is moving down sustainably toward 2%" as the catalyst to lower rates. Last year's view on rate cuts was in line with history: A negative shock prompts the Fed to move. The current view is anomalous. Though as Wilson notes, in the current market, what else would you expect? "The last couple of months have been a microcosm in this respect as economic growth data have once again cooled after a period of strength, while inflation data have been bumpy," Wilson wrote. "In short, macro outcomes have become increasingly hard to predict as data have become more volatile. We see this environment persisting." The Wall Street consensus for the S&P 500 has been shifting, with three strategists boosting their outlook for the benchmark index. Let's round up the latest changes.
Chart of the day BMO Capital Market's chief investment strategist Brian Belski boosted his year-end target to 5,600 from 5,100, noting that momentum in the market is "likely to persist." On Friday, Deutsche Bank chief equity strategist Binky Chadha boosted his year-end target for the benchmark to 5,500 from 5,100, noting robust earnings growth and an improving macroeconomic consensus. Then, on Sunday, one of the biggest bears on Wall Street over the past year joined the crowd. Morgan Stanley chief investment officer Mike Wilson now sees the S&P 500 hitting 5,400 in the next 12 months, up from his prior call that the index would fall to 4,500, driven by solid earnings growth.
As Myles writes in the Takeaway, there are notes of caution in Wilson's "bullish" call. Macro consensus has become "increasingly hard to predict" in the current environment, with the market shifting back and forth between a "soft landing" and "no landing" base case. Investors, he wrote, should be "ready for more rotations." But as our chart of the day shows, with Wilson no longer calling for a market decline, few on Wall Street see any further "rotations" sending stocks sinking to end the year. And to JPMorgan ... we are waiting patiently. — Josh Schafer, Markets Reporter
submitted by Andre3000RPI to DeercreekvolsBlog [link] [comments]
JPMorgan's succession story: JPMorgan CEO Jamie Dimon noted that his retirement was both closer than "five years away," his standard stock answer over the years, and that a succession plan was "well on the way." Talk of the CEO's departure moved the stock down 4.5%, despite the bank's good news: It revised its 2024 revenue expectations higher due to two potential rate cuts. The cuts would increase its net interest margin, a key banking metric marking the difference between what banks pay for deposits and what they make from them. Microsoft's new vision for AI: Microsoft announced its "Copilot+ PCs" on Monday, giving the world a look at how the most valuable company in the world plans to integrate its AI capabilities into consumer computers — capabilities that it hopes will reignite the PC market. Using specialized chips on the devices (no need for cloud processing), the ChatGPT-4o-based system assists users by seeing and analyzing what's already on the screen, integrating a key communication step. The software will be on Surface tablets as well as PCs from the usual suspects: Acer, ASUS, Dell, HP, Lenovo, and Samsung. The stock rose 1.2% Monday. 'A good position to hold steady': Monday's round of Fedspeak had Fed Vice Chair Philip Jefferson and Fed Vice Chair for Supervision Michael Barr concurring with a suite of their peers who have reiterated their wait-and-see approach to rates. One month of encouraging data isn't enough for them, and as Fed Chair Jerome Powell said last week, three months might be better.
Rising metal prices: Gold and copper hit records Monday as silver hit a 12-year high. Gold has been on a roll of late thanks to demand from central banks and potential Fed rate cuts. And copper, as a non-precious metal, has seen its value spike due to higher demand from machinery and wiring applications. Another picks-and-shovels AI trade, perhaps. What we're watching Morning Brief is written and edited by Ethan Wolff-Mann. For the web version, click here. Follow all the action throughout the day on Yahoo Finance and on the Yahoo Finance app.
Taylor Swift's economic boost is traveling from the US to Europe. Amid uncertainty around Social Security, here's what financial advisers are telling clients. Audi furthers EV push into China with new platform agreement. Housing experts revise mortgage rate forecasts for remainder of 2024. Secondhand Rolex sales surge in 'underdeveloped' US market. Wall Street's biggest bear flips, raises S&P 500 price target by 20%. What we're reading
Today's Takeaway is by Myles Udland, Head of News. One of the most notable bears on Wall Street finally flipped this week. Morgan Stanley's Mike Wilson raised his price target for the S&P 500 over the next 12 months to 5,400 from 4,500, a 20% jump amid a market Wilson sees defined by "higher than normal uncertainty." Josh Schafer has more on Wilson's call here. And in his report, Wilson included a chart that serves as a note of caution to stock market bulls looking for lower rates to power the next leg of this rally. "[There] is a wide array of return outcomes across history following the start of the cutting cycle," Wilson wrote. "In many ways, this analysis encapsulates our outlook well — a balanced risk/reward profile in the average/base line view, but the potential for a wide array of scenarios to play out. Once again, get ready for some notable swings in sentiment, positioning and prices."
Interest rate cuts have a complicated history with the stock market The S&P 500's average annual return is around 10%, making the 12-month returns that follow rate cuts, on average, well below this bogey. And with the exceptions of 1974, 1989, and 2019, year-ahead returns for the S&P 500 after rate cuts have typically been well outside this historical average both high and low. All else equal, lower interest rates benefit riskier assets like stocks, bringing down the return hurdle that makes stocks preferable to something like fixed income. What Wilson's data reminds us, however, is that rate cuts aren't something the Federal Reserve typically does "just because." Even the winning years in Wilson's chart are reminders of precarious moments in financial market history — the 1994 bond market crash gave rise to James Carville's famous complaints about "bond vigilantes," and 1998's emerging market crisis and collapse of LTCM forced the Fed to take drastic action to save a single hedge fund.
Go back 18 months and Wall Street expected a recession to prompt rate cuts. Today, the Fed is looking for "greater confidence that inflation is moving down sustainably toward 2%" as the catalyst to lower rates. Last year's view on rate cuts was in line with history: A negative shock prompts the Fed to move. The current view is anomalous. Though as Wilson notes, in the current market, what else would you expect? "The last couple of months have been a microcosm in this respect as economic growth data have once again cooled after a period of strength, while inflation data have been bumpy," Wilson wrote. "In short, macro outcomes have become increasingly hard to predict as data have become more volatile. We see this environment persisting." The Wall Street consensus for the S&P 500 has been shifting, with three strategists boosting their outlook for the benchmark index. Let's round up the latest changes.
Chart of the day BMO Capital Market's chief investment strategist Brian Belski boosted his year-end target to 5,600 from 5,100, noting that momentum in the market is "likely to persist." On Friday, Deutsche Bank chief equity strategist Binky Chadha boosted his year-end target for the benchmark to 5,500 from 5,100, noting robust earnings growth and an improving macroeconomic consensus. Then, on Sunday, one of the biggest bears on Wall Street over the past year joined the crowd. Morgan Stanley chief investment officer Mike Wilson now sees the S&P 500 hitting 5,400 in the next 12 months, up from his prior call that the index would fall to 4,500, driven by solid earnings growth.
As Myles writes in the Takeaway, there are notes of caution in Wilson's "bullish" call. Macro consensus has become "increasingly hard to predict" in the current environment, with the market shifting back and forth between a "soft landing" and "no landing" base case. Investors, he wrote, should be "ready for more rotations." But as our chart of the day shows, with Wilson no longer calling for a market decline, few on Wall Street see any further "rotations" sending stocks sinking to end the year. And to JPMorgan ... we are waiting patiently. — Josh Schafer, Markets Reporter
2024.05.22 00:30 TheGenkz Septem8er Tapes
 | I was recently organizing some of my old DVDs in storage and stumbled on a copy of a found footage film called SEPTEM8ER TAPES, a film that I have not rewatched in probably a good 15 years, but one that I think about a lot for some reason. submitted by TheGenkz to foundfootage [link] [comments] The film is a really interesting example of non-horror found footage, centering around an American journalist who travels to Afghanistan one year after 9/11, ostensibly to film a documentary. The film premiered at Sundance in 2004 and screened in many major festivals around the world. It got some buzz at the time because apparently the director, Christian Johnston, actually shot much of the film on location in Afghanistan, which as you might imagine, was not a super safe place for Americans to be around 2002-2003. It was picked up for distribution by a company called First Look Media, but as far as I can tell, it had an very limited or nonexistent theatrical run, and was released on DVD in 2005. Today, it very occasionally seems to pop up on AVOD streaming services, but I have not seen it be available for at least a few years. You can still find secondhand copies of the DVD for sale, but it doesn't look like the film was ever released in HD. The director put out another found footage film in 2007, this time in the sci-fi genre, called ALMAZ BLACK BOX. This one is even more obscure, and I've never seen it legitimately streaming, nor does it not look like it ever got a home video release in the US. It's particularly interesting because the film very clearly seems to be setting up a transmedia component via a tie-in website, which is no sadly no longer online. Between these two films, Christian Johnston seems to be a very intriguing filmmaker in the found footage subgenre, whose work is unfortunately becoming harder and harder to find. Has anyone else seen SEPTEM8ER TAPES? If so, what did you think? And does anyone here have more information on the director or his work? https://preview.redd.it/863myicawu1d1.jpg?width=1200&format=pjpg&auto=webp&s=abceb4f91cd13bfc22135faf86a91582f5324c45 |
2024.05.22 00:28 dradrado Is zero inhibiting cosmological understanding?
 | When theorising in astrophysics, and more specifically the beginning and expansion of the universe (the big bang), the phenomenon of black holes and the mysteries behind dark matter and dark energy, we mistakenly use the two concepts interchangeably, they being 1. The philosophical zero, ie nothingness, and 2. The mathematics concept of zero, ie summarily attaching the philosophical concept of zero, with a numerical designation because it greatly assists the functionality of mathematic in the paradigm of our observable reality. Also please bearing mind the the math concept of zero allows negative values, unlike the philosophy, and when discussing space time, there is no place for negative numbers. Now that said and made clear, I believe it impossible for us to attempt to explain the unimaginable, without separation and distinction of the two concepts when infinity is brought into the conversation. Infinity, like zero, is a philosophical concept not all that dissimilar to zero, it has a mathematical conceptual basis also, but unlike the philosophical zero ie nothingness, it is given a numerical designation that more accurately relates to it philosophically, even though it is not strictly a number and cannot he used in any tangible calculation, mathematics certainly allows for its philosophical manifestation into mathematical equations. submitted by dradrado to ZeroOrInfinity [link] [comments] I see this as a huge conflict, especially as it the very essence of big bang theory ie from nothing came infinity at the moment of the big bang. We surely cannot hope to solve this puzzle if the universe if we are conceptually flawed at he very starting point. 0 and infinity therefore cannot be used together in any calculation because we haven't yet reconciled the two conceptually. How can we look at this differently? How can we navigate passed mathematical dogma a concepts our brains are not capable of truly understanding on a practical level? These are very tough existential and philosophical problems. So rather than just critise the current order and point out what I see as conflicts, but offer no alternative, may I suggest at least a starting point for discussion and exploration which may be found in the area of fractal science/mathematics. And a good place to focus the beginning of any theoretical discourse, in my opinion would be the work of, amoung others, Mandelbrot and the set named after him, the Mandelbrot Set. I suggest this because it mathematically the most relevant area of a field and is largely avoided by the popular culture's interest in fractals which is largely forcused on aesthetical beauty, particularly popular with the psychedelic subculture which I believe has a place and time to be investigated as a part of the whole discussion, but maybe for now should not be a point of focus in fear of contaminating a sterile discussion with with larger philosophically arguments about what is reality, due to the psychedelic substance insights of those schools. To incorporate any talk of altered states of consciousness, may be counter productive at this time. Hence my Mandelbrot suggestion achieves the mathematical parameters I believe are the best for theoretical mathematical support and cancels out the annoying noise that the fractal science field makes due to its attractiveness to non mainstream pop culture. The Mandelbrot set is intriguing, not only because of the almost mindblowing graphical capability of AI, for as the Mandelbrot set seen by AI and then visualised for us to see, is nothing short of unbelievably beautiful. It also has an ability to provoke inner hought and discourse without one knowing the subject, topic or reason for the quiet peaceful internal discourse it inspires. I mention this, not because it can directly be incorporated in the radical discussion, but experiencing the astonishlng complexity if its beauty and the way it continues infinitely (or rather as long as it continues to be observed) because if the very self contained nature of the Mandelbrot set. After all, the mandelbrit set is simply a set of numbers, that when placed in the equation, do not spiral out into infinity. The equation value is always >0 or <2. So what as I see as irony, as the set was designed to avoid infinity in a sense, what it actually does is provide us with the best possible conceptualisation, in practice and theory, of a model demonstrating infinity. Even more bizarre is that the technology had only recently become available to show us visually by AI graphing. I'm not sure without the visual stimulus, could we have seen how beautifully fractal science demonstrates its potential unravelling existential and theoretical mysteries. I believe it lends itself perfectly to my proposed theory. I think so because infinity is difficult for the human mind to grasp, some may say impossible. What is even more difficult for our minds to grasp is infinity of reducted values. Basically, if infinity can exist in an expanding sense, then it is not a stretch of conceptualisation to think it can infinitely get smaller. This breaks no rules of science. Searching for the building block of the universe has been crusade of quantum physicists dating back to the creation of the scientific theory. Much money and effort has been spent in search for smaller and smaller still subatomic particles. What they do is fractal science in its purest form, yet like with the study of Theoretical Astrophysics, quantum science theory is its self hampered by the concept if zero as a number, in my opinion. Even doing the work of factually reducing matter, they are blinded to its possible futility, should fractal reduction does forever decend in to fractal infinity or -ve infinity. For if that is the case, maybe quantum theory is in fact mankind's first exploration, albeit unknowingly, into what may well be a black hole. That is for a later discussion but certainly worth bringing to the attention for the purposes of this discussion. So if we can accept that -ve infinity is as equally viable and logical as +ve infinity, what room in this discussion is left for the inclusion of zero? I believe this leaves no room for zero in the same conversation as infinity. I am not suggesting zero should be stricken from mathematics. However I am suggesting that mathematics use of zero may, invalidate is ongoing use as an effective tool for measurement and communication, when the subject is beyond our ability to comprehend. Few people will argue that our 6 senses are significantly lacking the capacity to comprehend cosmological dynamics. Mathematics nothing more than an application of our 6 senses, to make sense of the chaos occurring all around us. Over hundreds and thousands of years, this is the best we have been able to do in terms of calculation and accurate prediction of future occurances. Even the concept of zero is less than 1000 years old. The Romans saw no use in incorporating it into their model, and to this day we wonder at their and other ancient civilisations ability for astonishing accuracy in measurement and prediction. Look at all they, the Egyptians and others managed without using zero in a single calculation. We can also break this down out of our conscious paradigm into nature. Numbers do not exist in nature (that includes the universe). It begs the question of do numbers really exist? Are numbers no more than part of our delusional reality? Who knows, but one thing is for sure, zero certainly doesn't exist anywhere outside of our consciousness. Not even in our own very bodies. How bodies clearly hold a knowledge that hasn't seemed to be passed over to our conscious, aware selves. Even on the smallest scale, without any intervention or guidance from any sort of intelligence, within our cellular membranes. Complex calculations are constantly being carried out. Consider cellular replication for example. In order for a cell to divide successfully, there must be a correct allocation of resources, let's just say primarily energy distribution for the sake of brevity. To split a cell but calculate the energy necessary to simply cary put the force of splitting. It must also calculate how much energy needs to be transfered to the new cell. This calculation must include how much energy for it take to replicate all cellular matter, how much energy is required for both cells to recover from the trauma, and how much energy on top of that, the new cell will require to become mature and begin its own replication. There are multiple complex calculations to be made there, and they then must be combined in to an overall and more complicated calculation again. All of this is done without intelligence and without using numbers ie mathematics. This same process can be observed all the way back to the very first beginning of not just life, but biochemistry in general. So I hope this demonstrates that the universe doesn't exist numerically. There are no rules in the universe. We created rules for our sciences, because if we didn't follow them the sciences would fail at unacceptable percentage of predictions So we make rules to overcome the shortcomings while waiting for future technologies or fixes. Mathematics and sciences are little more than a carefully ordered tapestry of rules, with too many exeptions for too many rules. We create rules and ideas to assist the conteived & malfunctioning intangible thing to not have to go to all the trouble of finding something that works better. We are just littered with examples through every field. Like 'zero', or Pi, or "bimdas" (brackets, indicies, multiply, division, addition and subtraction. I find this a good example, for not following this exact order of calculations, a correct answer to equation will nev a result) and thousands of others. No rules exist in nature, it appears to be that it just is, always will be and always has been. So in summary, given our restrictions on trying to understand the universe, namely intelligence, our 6 limited senses, our arrogance and our mortality, should we narrow the pursuits our restrictions can make us comfortable with? Thisbwilk lead us nowhere. By abandoning zero as the only accepted scientific approach to the universe, and allowing science to have multiple validating throeries for what is the same problem. The scientific community abhors divergence from dogma and academics are held to ransom with funding or being published, if their ideas are not with acceptable parameters. But for the sake of this conversation, can we discuss the merits of looking at the big bang without reference to nothing ie zero, but instead +ve and -ve infinity." |
2024.05.22 00:23 Charming_Barnacle_24 Is research really more stressful than other jobs? Any alternatives for ecology or disease based graduate?
Is being in academia really more stressful other jobs?
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet).
submitted by Charming_Barnacle_24 to AskAcademiaUK [link] [comments]
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet).
2024.05.22 00:23 JustAnAnon87348 My older Sister is NC with our parents and I am trapped in the middle between them.
I 24F have an older sister 27F who has been NC with our parents since April 2023, I have limited communication with her as she is mentally unwell (we are both on antidepressants etc) and regularly have calls with my parents every few days. The final straw for my sister was an argument in April 2023 sparked by my dad misgendering and deadnaming after I came out to them as being a male-to-female trans woman at that shortly before and afterwards my sister went into limited and then no contact with them.
Though this was the final straw for her there were obviously a lot of things before that happened to eitheor both of us and my sister has in length explained this to them. Emotional manipulation such as guilt, shaming, calling her a bad older sister to me and that one day I would stop forgiving her, that my parents would leave her (fear of abandonment was the main way we were controlled and disciplined).
Couple of examples: 1: from 2005 to 2008 we were taken out of school so our parents could travel parts of the world with us and during this time we were homeschooled and had little interaction with other kids our age assuming they even spoke English, one day my sister (age 9) refused to do her schoolwork they’d set so my dad after shouting at her threw her passport at her and told her they’d just send her back home to live with our grandmother till they came back in two years. 2: My sister’s first memory as an infant is refusing to sit still in her booster seat in the car so my dad took her out, put her on the pavement and drove round the corner out of sight for a few minutes to scare her into behaving. (My dad has talked about these with me and how he has asked other parents opinions and they’ve all said this wasn’t anything bad, there are plenty more examples)
3: When I was 6 and misbehaved (I threw a pebble at a dog and I am obviously ashamed) my dad went ballistic and threatened to leave me behind when they leave for their next destination). 4: when I was 13 and talked back at my mum (I was being a moody kid with a bad attitude) he came into my room when I was asleep to tell me if he had to choose between me and my mum he’d “pick her”.
Honestly we were taught to never approach them for anything or to say when there was a problem as we were scared of him getting angry.
It’s difficult for me as I love my sister and see her as the only true family I have in the traditional sense yet she never really talks to me (I understand and accept it’s hard for her but obviously it makes me feel alone) and still have regular conversations and dependant on them financially till I graduate from my degree next year. I still love them because some part of me always will I feel but I can never forgive them and at least till Im Independant can not confront them as I’m reliant on them and also don’t want to see them hurt more than they already do (My mum is likely also going to be starting antidepressants in the next couple weeks).
I guess I just feel kind of stranded in no mans land, I love my parents despite my dad being abusive and manipulative and my mum an enabler and don't want to see them hurting but I also can't forgive them for how much they've damaged me and my sister but I am dependant on them and if I am being honest their massive financial support during my degree. I love my sister and absolutely support her choice of NC with them and acknowledge she needs distance but at times feel resentful that the one person I can call family has seemingly abandoned me to them and I feel guilty for feeling that way.
This ended up being more of a rant and getting to speak these thoughts somewhere rather than keeping them to myself.
If you read this then thanks, and if you didn't then I don't blame you it got pretty longwinded.
tldr: I simulatenously hate/love my parents and support/resent my sister for leaving me alone with them.
submitted by JustAnAnon87348 to EstrangedAdultChild [link] [comments]
Though this was the final straw for her there were obviously a lot of things before that happened to eitheor both of us and my sister has in length explained this to them. Emotional manipulation such as guilt, shaming, calling her a bad older sister to me and that one day I would stop forgiving her, that my parents would leave her (fear of abandonment was the main way we were controlled and disciplined).
Couple of examples: 1: from 2005 to 2008 we were taken out of school so our parents could travel parts of the world with us and during this time we were homeschooled and had little interaction with other kids our age assuming they even spoke English, one day my sister (age 9) refused to do her schoolwork they’d set so my dad after shouting at her threw her passport at her and told her they’d just send her back home to live with our grandmother till they came back in two years. 2: My sister’s first memory as an infant is refusing to sit still in her booster seat in the car so my dad took her out, put her on the pavement and drove round the corner out of sight for a few minutes to scare her into behaving. (My dad has talked about these with me and how he has asked other parents opinions and they’ve all said this wasn’t anything bad, there are plenty more examples)
3: When I was 6 and misbehaved (I threw a pebble at a dog and I am obviously ashamed) my dad went ballistic and threatened to leave me behind when they leave for their next destination). 4: when I was 13 and talked back at my mum (I was being a moody kid with a bad attitude) he came into my room when I was asleep to tell me if he had to choose between me and my mum he’d “pick her”.
Honestly we were taught to never approach them for anything or to say when there was a problem as we were scared of him getting angry.
It’s difficult for me as I love my sister and see her as the only true family I have in the traditional sense yet she never really talks to me (I understand and accept it’s hard for her but obviously it makes me feel alone) and still have regular conversations and dependant on them financially till I graduate from my degree next year. I still love them because some part of me always will I feel but I can never forgive them and at least till Im Independant can not confront them as I’m reliant on them and also don’t want to see them hurt more than they already do (My mum is likely also going to be starting antidepressants in the next couple weeks).
I guess I just feel kind of stranded in no mans land, I love my parents despite my dad being abusive and manipulative and my mum an enabler and don't want to see them hurting but I also can't forgive them for how much they've damaged me and my sister but I am dependant on them and if I am being honest their massive financial support during my degree. I love my sister and absolutely support her choice of NC with them and acknowledge she needs distance but at times feel resentful that the one person I can call family has seemingly abandoned me to them and I feel guilty for feeling that way.
This ended up being more of a rant and getting to speak these thoughts somewhere rather than keeping them to myself.
If you read this then thanks, and if you didn't then I don't blame you it got pretty longwinded.
tldr: I simulatenously hate/love my parents and support/resent my sister for leaving me alone with them.
2024.05.22 00:22 Charming_Barnacle_24 Non stressful alternatives to ecological research career?
Is being in academia really more stressful other jobs?
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet). In the UK, so cant do all those cool jobs you Americans get with the fish and wildlife service.
submitted by Charming_Barnacle_24 to ecology [link] [comments]
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet). In the UK, so cant do all those cool jobs you Americans get with the fish and wildlife service.
2024.05.22 00:22 Cromborz First Tried Morgott, Am I Over-levelled?
Soo... I just killed Morgott on my very first attempt and I don't feel good about it. Last challenge I had before this was Rykard and he was really difficult to beat for me and so I was looking forward to another boss to get stuck on for a lot of attempts, but I think I may be too over-levelled...
For reference, my only other souls game is Sekiro and I play Elden Ring like a lunatic where I complete every branching path of exploration and bits of dungeon crawling before I progress the next section of the game. I don't do this to farm anything (I don't farm runes), I just do it because I must, that's how I feel I'm having fun. For example, just before Morgott, I did my best to clean up the entirety of Leyndell and all the areas before that too including Volcano Manor, Caelid, Raya Lucaria etc.
During the Morgott fight, I was Level 113 with a Dismounter +9 and Bloodhound Fang +9 rocking a Str + Dex + Faith build. I also had the Golden Vow, Flame Grant Me Strength, Bloodflame Blade, and wondrous physick damage buffs on me (I cast/consumed right before the fog because I knew it was going to be a boss fight).
During the fight, I managed to dodge a few of his attacks with bloodhound fang special + heavy combo (while doing the heavy is when I dodged most of the things as I become invisible/get iframes), which was really lucky. On top of this, I managed to bleed him at some point which did a lot of damage. He got me down to like 10 HP at some point but I managed to recover.
Even if it was a close call and I was lucky with my dodges, the fight still didn't feel good unfortunately because I was looking forward to getting stuck at a boss since Rykard. My question to you is, do you think I am over-levelled? Am I using a weapon that is way too strong in terms of special? Does all the incantations make me way too powerful? What are your recommendations for future bosses?
submitted by Cromborz to Eldenring [link] [comments]
For reference, my only other souls game is Sekiro and I play Elden Ring like a lunatic where I complete every branching path of exploration and bits of dungeon crawling before I progress the next section of the game. I don't do this to farm anything (I don't farm runes), I just do it because I must, that's how I feel I'm having fun. For example, just before Morgott, I did my best to clean up the entirety of Leyndell and all the areas before that too including Volcano Manor, Caelid, Raya Lucaria etc.
During the Morgott fight, I was Level 113 with a Dismounter +9 and Bloodhound Fang +9 rocking a Str + Dex + Faith build. I also had the Golden Vow, Flame Grant Me Strength, Bloodflame Blade, and wondrous physick damage buffs on me (I cast/consumed right before the fog because I knew it was going to be a boss fight).
During the fight, I managed to dodge a few of his attacks with bloodhound fang special + heavy combo (while doing the heavy is when I dodged most of the things as I become invisible/get iframes), which was really lucky. On top of this, I managed to bleed him at some point which did a lot of damage. He got me down to like 10 HP at some point but I managed to recover.
Even if it was a close call and I was lucky with my dodges, the fight still didn't feel good unfortunately because I was looking forward to getting stuck at a boss since Rykard. My question to you is, do you think I am over-levelled? Am I using a weapon that is way too strong in terms of special? Does all the incantations make me way too powerful? What are your recommendations for future bosses?
2024.05.22 00:21 Charming_Barnacle_24 Less stressful alternatives to ecology or disease research career?
Is being in academia really more stressful other jobs?
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet).
submitted by Charming_Barnacle_24 to findapath [link] [comments]
Been accepted for funded ecology phd. So I'm thinking of going into a research career but getting cold feet. Ive only just started relaxing again out of university where it was 24/7 work really. Being at my rubbish summer job is heaven because i go to work, and then can forget about it when i come home. I work 7-8 hours a day and actually get paid per hour. Im worried going into a PhD ill be back to square one, no work life balance. Which i could just about cope with for four years. But now im realising the rest of my career as a postdoc and beyond might be the same. Where i work 9-5, then come home and realise actually i should do some work on that paper or grant proposal. It seems like so many people in research are happy to sacrifice a work life balance, so i will have to too to keep up with them.
But im also realising that most others jobs i want to do will be like this. Other jobs like civil service (project management kinda stuff), scientific communication, even non profit work. All things where I'll probably feel forced to work on things outside work to stay ahead. It seems like i can't find a career thats a mix of stimulating and lets me switch off. Any help?
In terms of careers i might want to do, preferably anything that involves travel and stokes me inbuilt need to feel clever. But also where i can switch off, ideally ones where i physically cant do the work at home. Im interested in ecology, marine biology, paleontology, and disease (human and vet).
2024.05.22 00:20 gttstd PRISM MarketView Highlights Soligenix, Inc. as it Builds on Compelling Phase 3 Data with Key Catalysts on the Horizon
NEW YORK, May 21, 2024 (GLOBE NEWSWIRE) -- PRISM MarketView presents an in-depth interview with Dr. Christopher Schaber, President and Chief Executive Officer of Soligenix, Inc. (Nasdaq: SNGX). The late-stage biopharmaceutical company is advancing a broad pipeline of therapeutic and vaccine candidates across its two business segments, emphasizing its strategic focus on diversified drug development.
Soligenix has recently achieved success in its first Phase 3 clinical trial of HyBryte™ (synthetic hypericin) for cutaneous T-cell lymphoma (CTCL), a rare and chronic cancer. The trial showed statistical significance in its primary endpoint, and a second confirmatory Phase 3 study is set to commence in 2024. HyBryte™ has received Orphan Drug Designations from both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA), along with Fast Track status from the FDA. These developments underscore a potentially de-risked path to regulatory approvals worldwide.
In addition to its robust biotherapeutics portfolio, which includes active clinical programs in psoriasis and Behçet’s disease, Soligenix has an established Public Health Solutions business. This segment is advancing heat-stable vaccines and therapeutics, notably with its proprietary ThermoVax® process, which enables lyophilization without compromising potency — a critical factor in areas lacking cold chain logistics.
logodehazesearch PRISM MarketView Highlights Soligenix, Inc. as it Builds on Compelling Phase 3 Data with Key Catalysts on the Horizon May 21, 2024 12:35 ET Source: PRISM MarketView
NEW YORK, May 21, 2024 (GLOBE NEWSWIRE) -- PRISM MarketView presents an in-depth interview with Dr. Christopher Schaber, President and Chief Executive Officer of Soligenix, Inc. (Nasdaq: SNGX). The late-stage biopharmaceutical company is advancing a broad pipeline of therapeutic and vaccine candidates across its two business segments, emphasizing its strategic focus on diversified drug development.
Soligenix has recently achieved success in its first Phase 3 clinical trial of HyBryte™ (synthetic hypericin) for cutaneous T-cell lymphoma (CTCL), a rare and chronic cancer. The trial showed statistical significance in its primary endpoint, and a second confirmatory Phase 3 study is set to commence in 2024. HyBryte™ has received Orphan Drug Designations from both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA), along with Fast Track status from the FDA. These developments underscore a potentially de-risked path to regulatory approvals worldwide.
In addition to its robust biotherapeutics portfolio, which includes active clinical programs in psoriasis and Behçet’s disease, Soligenix has an established Public Health Solutions business. This segment is advancing heat-stable vaccines and therapeutics, notably with its proprietary ThermoVax® process, which enables lyophilization without compromising potency — a critical factor in areas lacking cold chain logistics.
Dr. Schaber shared insights into the recent publication of HyBryte results in the Journal of the European Academy of Dermatology & Venereology. The open-label study, involving nine patients, showed significant improvements in CTCL lesions, confirming the efficacy seen in the Phase 3 FLASH trial. "Our clinical studies have demonstrated HyBryte's strong and rapid efficacy and a benign safety profile. It's applicable across various lesion types, skin tones, and stages of disease," said Dr. Schaber.
Addressing the public health solutions segment, Dr. Schaber highlighted the advancement of vaccine candidates for ricin toxin, Sudan ebolavirus, Marburg marburgvirus, and COVID-19. Soligenix is particularly focused on pursuing FDA approval for RiVax® under the FDA's animal rule and expects to publish preclinical study results in the second half of 2024. The segment has already secured over $30 million in NIH funding and grants.
For 2024, Soligenix is poised to achieve several key milestones. "We will be enrolling the first patients in our 18-week Phase 3 placebo-controlled study evaluating HyBryte™ in CTCL across the US and Europe. We also anticipate reporting expanded results from our Phase 2a study of SGX302 in psoriasis and initiating a Phase 2a clinical study of SGX945 for aphthous mouth ulcers in Behçet's Disease," Dr. Schaber explained.
submitted by gttstd to Soligenix [link] [comments]
Soligenix has recently achieved success in its first Phase 3 clinical trial of HyBryte™ (synthetic hypericin) for cutaneous T-cell lymphoma (CTCL), a rare and chronic cancer. The trial showed statistical significance in its primary endpoint, and a second confirmatory Phase 3 study is set to commence in 2024. HyBryte™ has received Orphan Drug Designations from both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA), along with Fast Track status from the FDA. These developments underscore a potentially de-risked path to regulatory approvals worldwide.
In addition to its robust biotherapeutics portfolio, which includes active clinical programs in psoriasis and Behçet’s disease, Soligenix has an established Public Health Solutions business. This segment is advancing heat-stable vaccines and therapeutics, notably with its proprietary ThermoVax® process, which enables lyophilization without compromising potency — a critical factor in areas lacking cold chain logistics.
logodehazesearch PRISM MarketView Highlights Soligenix, Inc. as it Builds on Compelling Phase 3 Data with Key Catalysts on the Horizon May 21, 2024 12:35 ET Source: PRISM MarketView
NEW YORK, May 21, 2024 (GLOBE NEWSWIRE) -- PRISM MarketView presents an in-depth interview with Dr. Christopher Schaber, President and Chief Executive Officer of Soligenix, Inc. (Nasdaq: SNGX). The late-stage biopharmaceutical company is advancing a broad pipeline of therapeutic and vaccine candidates across its two business segments, emphasizing its strategic focus on diversified drug development.
Soligenix has recently achieved success in its first Phase 3 clinical trial of HyBryte™ (synthetic hypericin) for cutaneous T-cell lymphoma (CTCL), a rare and chronic cancer. The trial showed statistical significance in its primary endpoint, and a second confirmatory Phase 3 study is set to commence in 2024. HyBryte™ has received Orphan Drug Designations from both the U.S. Food and Drug Administration (FDA) and European Medicines Agency (EMA), along with Fast Track status from the FDA. These developments underscore a potentially de-risked path to regulatory approvals worldwide.
In addition to its robust biotherapeutics portfolio, which includes active clinical programs in psoriasis and Behçet’s disease, Soligenix has an established Public Health Solutions business. This segment is advancing heat-stable vaccines and therapeutics, notably with its proprietary ThermoVax® process, which enables lyophilization without compromising potency — a critical factor in areas lacking cold chain logistics.
Dr. Schaber shared insights into the recent publication of HyBryte results in the Journal of the European Academy of Dermatology & Venereology. The open-label study, involving nine patients, showed significant improvements in CTCL lesions, confirming the efficacy seen in the Phase 3 FLASH trial. "Our clinical studies have demonstrated HyBryte's strong and rapid efficacy and a benign safety profile. It's applicable across various lesion types, skin tones, and stages of disease," said Dr. Schaber.
Addressing the public health solutions segment, Dr. Schaber highlighted the advancement of vaccine candidates for ricin toxin, Sudan ebolavirus, Marburg marburgvirus, and COVID-19. Soligenix is particularly focused on pursuing FDA approval for RiVax® under the FDA's animal rule and expects to publish preclinical study results in the second half of 2024. The segment has already secured over $30 million in NIH funding and grants.
For 2024, Soligenix is poised to achieve several key milestones. "We will be enrolling the first patients in our 18-week Phase 3 placebo-controlled study evaluating HyBryte™ in CTCL across the US and Europe. We also anticipate reporting expanded results from our Phase 2a study of SGX302 in psoriasis and initiating a Phase 2a clinical study of SGX945 for aphthous mouth ulcers in Behçet's Disease," Dr. Schaber explained.
2024.05.22 00:17 tropicsea Advise on Moving for a Job Opportunity
Hello!
I am looking for some advice on moving for an (internal) job opportunity. I am 27F and about 4 years into my career.
I currently work at a cancer genetic testing lab on the operations side. My role could be described as a Clinical Data Analyst. It's super chill, I work 4 10s, fully remote, 3 weeks of PTO, pay is hourly but last year made ~ 60k a year. I struggle with this job because it is the same thing every day, every moment of the day and is completely production/metrics based. I got into this job because I wanted to be on the technical side of things and thought it would help me get into genetic counseling school but that goal died after one cycle of applications. So I see this job as something I can do while pursuing a masters degree and super chill/low stress but also not challenging at all and theres no opportunity for growth (title/responsibilities/pay) in this position.
I have been applying internally for positions that are more client facing. I recently applied for an entry level sales position. I have always worked in labs/clinics so this is way different than anything I've ever considered but thought the pay would be better and it'd be more variable in the day to day. The position is based out of a larger US city and is a remote/field based position. I have done 5 different interviews trying to get a gauge for the job and it sounds like 50% of the day, I would be driving around. This job would put me at close to 100k (salary), PTO is unlimited, and maybe I could still pursue a masters degree. The caveat is that I would (1) have to move (2) have to give up my fully remote job and lose the opportunity to travel around and work (3) I have been at my company 3 years and they said they would not offer relocation money.
So I am wondering what your alls advice is on moving (almost across the country) for a job. I have been applying to jobs for almost a year now and haven't even gotten this far into the interview process where an offer is on the table so it feels like maybe it's the only opportunity coming for the foreseeable future. Do you all feel that medical/biotech sales is a way to gain more business side experience? Or is a sales rep another "dead end" job?
Thank you so much!
submitted by tropicsea to biotech [link] [comments]
I am looking for some advice on moving for an (internal) job opportunity. I am 27F and about 4 years into my career.
I currently work at a cancer genetic testing lab on the operations side. My role could be described as a Clinical Data Analyst. It's super chill, I work 4 10s, fully remote, 3 weeks of PTO, pay is hourly but last year made ~ 60k a year. I struggle with this job because it is the same thing every day, every moment of the day and is completely production/metrics based. I got into this job because I wanted to be on the technical side of things and thought it would help me get into genetic counseling school but that goal died after one cycle of applications. So I see this job as something I can do while pursuing a masters degree and super chill/low stress but also not challenging at all and theres no opportunity for growth (title/responsibilities/pay) in this position.
I have been applying internally for positions that are more client facing. I recently applied for an entry level sales position. I have always worked in labs/clinics so this is way different than anything I've ever considered but thought the pay would be better and it'd be more variable in the day to day. The position is based out of a larger US city and is a remote/field based position. I have done 5 different interviews trying to get a gauge for the job and it sounds like 50% of the day, I would be driving around. This job would put me at close to 100k (salary), PTO is unlimited, and maybe I could still pursue a masters degree. The caveat is that I would (1) have to move (2) have to give up my fully remote job and lose the opportunity to travel around and work (3) I have been at my company 3 years and they said they would not offer relocation money.
So I am wondering what your alls advice is on moving (almost across the country) for a job. I have been applying to jobs for almost a year now and haven't even gotten this far into the interview process where an offer is on the table so it feels like maybe it's the only opportunity coming for the foreseeable future. Do you all feel that medical/biotech sales is a way to gain more business side experience? Or is a sales rep another "dead end" job?
Thank you so much!
2024.05.22 00:13 J_Phillip-I-Fry (Online)(5E-D&D)(Weekly)(Sundays)(9PM-MST)(Any Experience Level)(18+)(Low Magic) Monster of the week style campaign set in Ancient Rome
Hello folks,
Looking for people to play in an upcoming campaign starting in June. We will be using discord for voice and Owlbear Rodeo for battlemaps. ideally id love to make some friends from this, but will settle for a consistent dnd group.
First, some basic requirements:
Decent Mic (voice chat required)
Consistent Schedule (missing more than a couple session without a good excuse will result in a kick)
Human Decency (Treat any Human, regardless of background with respect)(this game is open to LGBT+ and whoever)
18+ (Game will have no sexual content beyond the mention of sex)
Now that that's out of the way, some basic rules for the campaign:
Restricted Races (If you REALLY want to play something we can talk about that *See questionnaire at bottom of post*)
Monster of the week style (will explain more during summary)
Low magic (No Druids, Bards, Clerics, Wizards, Sorcerers allowed, on the fence about warlocks)
Mid Fantasy (Magic items exist, monsters exist)
30%-30%-40% (RP-Exploration-Combat)
Campaign summary:
You are a tasked by the Emperor (for one reason or another) to serve as part of a secretive special group of soldiers who journey throughout the Empire hunting threats ranging from monsters to the supernatural. With the backing of the Empire in Roman territory (though you may not always be in Roman territory) you can usually find food, shelter and other basic requirements provided with ease. You will do your best to gather information about the creature (weaknesses, location, amount, etc.) before confronting it. Due to the secretive nature of your group, and the unpredictable state of the land you're travelling through sometimes you will also be confronted with Humanoid enemies (bandits, rebels, enemy empires) from time to time, as well as some threats that dont fall within your duty (goblins, orcs, etc), its up to you to decide how to handle those threats. From time to time the party will be gifted powerful artifacts in the form of magic items to aid them in their journey.
Session information:
Voice chat over discord, Battle maps on Owlbear Rodeo, Weekly on Sunday evenings (start time can be changed if it works better for players) 3-5 hour sessions with a 10 minute break somewhere.
About myself:
Pierce-28M, Been playing/ DMing dnd for 2-3 years consistently, just finished running a year long campaign for some LFG peeps, I make most of the maps i use and generally homebrew monsters to fight, while using the monster manual to supplement them. Im by no means a professional DM, and can struggle with RP from time to time, but will always do my best to create an enjoyable experience.
I like to watch anime, play games, i use to make music, and i enjoy chatting about life in general.
Allowed Races:
Dwarf, Elf, Gnome, Human, half-elf, halfling, Genasi, Goliath, Triton, Yaun-ti and Leonin
(if you REALLY, really want to play something else we can chat about that)
Application Process:
A small Questionnaire, followed by a short interview in discord.
Please DM me with the following on reddit and i will answer within a day or two.
submitted by J_Phillip-I-Fry to lfg [link] [comments]
Looking for people to play in an upcoming campaign starting in June. We will be using discord for voice and Owlbear Rodeo for battlemaps. ideally id love to make some friends from this, but will settle for a consistent dnd group.
First, some basic requirements:
Decent Mic (voice chat required)
Consistent Schedule (missing more than a couple session without a good excuse will result in a kick)
Human Decency (Treat any Human, regardless of background with respect)(this game is open to LGBT+ and whoever)
18+ (Game will have no sexual content beyond the mention of sex)
Now that that's out of the way, some basic rules for the campaign:
Restricted Races (If you REALLY want to play something we can talk about that *See questionnaire at bottom of post*)
Monster of the week style (will explain more during summary)
Low magic (No Druids, Bards, Clerics, Wizards, Sorcerers allowed, on the fence about warlocks)
Mid Fantasy (Magic items exist, monsters exist)
30%-30%-40% (RP-Exploration-Combat)
Campaign summary:
You are a tasked by the Emperor (for one reason or another) to serve as part of a secretive special group of soldiers who journey throughout the Empire hunting threats ranging from monsters to the supernatural. With the backing of the Empire in Roman territory (though you may not always be in Roman territory) you can usually find food, shelter and other basic requirements provided with ease. You will do your best to gather information about the creature (weaknesses, location, amount, etc.) before confronting it. Due to the secretive nature of your group, and the unpredictable state of the land you're travelling through sometimes you will also be confronted with Humanoid enemies (bandits, rebels, enemy empires) from time to time, as well as some threats that dont fall within your duty (goblins, orcs, etc), its up to you to decide how to handle those threats. From time to time the party will be gifted powerful artifacts in the form of magic items to aid them in their journey.
Session information:
Voice chat over discord, Battle maps on Owlbear Rodeo, Weekly on Sunday evenings (start time can be changed if it works better for players) 3-5 hour sessions with a 10 minute break somewhere.
About myself:
Pierce-28M, Been playing/ DMing dnd for 2-3 years consistently, just finished running a year long campaign for some LFG peeps, I make most of the maps i use and generally homebrew monsters to fight, while using the monster manual to supplement them. Im by no means a professional DM, and can struggle with RP from time to time, but will always do my best to create an enjoyable experience.
I like to watch anime, play games, i use to make music, and i enjoy chatting about life in general.
Allowed Races:
Dwarf, Elf, Gnome, Human, half-elf, halfling, Genasi, Goliath, Triton, Yaun-ti and Leonin
(if you REALLY, really want to play something else we can chat about that)
Application Process:
A small Questionnaire, followed by a short interview in discord.
Please DM me with the following on reddit and i will answer within a day or two.
- Name/Age/Pronouns
- Discord Name
- Experience with 5e, expectations for the campaign (Lethality on a scale of 1-10, topics youd like to avoid, etc.)
- Character idea (not required, if you want to play a restricted race, tell me the race/reason youd like to play it)
- little bit about yourself (1-3 sentences minimum, but feel free to say as much as youd like)
- Any questions you might have for me.
2024.05.22 00:12 SquiffSquiff Custom GPT equivalent on Bedrock - Do I have this process right? Really?!
Today I was struggling with some documentation on a hosted public cloud application. Ironically this is an AWS hosted proprietary service with poor google visibility or local search but it could be anything. I 'built and trained' a Custom GPT in about ten minutes. Looks good but I am not allowed to share it by default because 'it references trademarks'. OK, well, appeal, and maybe I can use Bedrock instead. Do I really have this right?
I sign in to AWS and go to Bedrock.
Oh yeah, and much of this is console only apparently...
Is this seriously what AWS are doing for a service that they want uptake on? Alternatively I could deploy a Kubernetes cluster with Llama3 and openwebui completely in code. For a 'complete' example on an odd-bod cloud see this. Might need to do some tweaks to read websites but not write original code. I suppose it might be even simpler to simply hook a front end on my website up to an OpenAI/Anthropic etc backend API.
In other words I can have a complete implementation in code for an LLM 'self hosted' that I would expect (after assembly!) to deploy in less than 30 minutes with high availability etc, a web front end and its own site crawler. I can do this in AWS, test out, tear down, not worry about leaving anything potentially expensive running and transfer verbatim to a client site without having to grant myself or request special permission or wait or be potentially refused.
What am I supposed to be considering paying Amazon for here again?
submitted by SquiffSquiff to aws [link] [comments]
I sign in to AWS and go to Bedrock.
- I have to enable permission for my (admin) user to use Bedrock
- I have to make a request for the specific model(s) I want access to, i.e. this request may be denied, and wait. Apparently the UI is terrible in this respect so not sure how long that might take.
Oh yeah, and much of this is console only apparently...
Is this seriously what AWS are doing for a service that they want uptake on? Alternatively I could deploy a Kubernetes cluster with Llama3 and openwebui completely in code. For a 'complete' example on an odd-bod cloud see this. Might need to do some tweaks to read websites but not write original code. I suppose it might be even simpler to simply hook a front end on my website up to an OpenAI/Anthropic etc backend API.
In other words I can have a complete implementation in code for an LLM 'self hosted' that I would expect (after assembly!) to deploy in less than 30 minutes with high availability etc, a web front end and its own site crawler. I can do this in AWS, test out, tear down, not worry about leaving anything potentially expensive running and transfer verbatim to a client site without having to grant myself or request special permission or wait or be potentially refused.
What am I supposed to be considering paying Amazon for here again?
2024.05.22 00:11 Sweet-Count2557 Michael in New York City, USA
 | Michael in New York City, USA submitted by Sweet-Count2557 to worldkidstravel [link] [comments] Experience Comfort and Convenience at Michael: The Best Budget-Friendly Hotel in New York City Price Level: Hotel Class: 0.0 When it comes to finding a comfortable and affordable place to stay in New York City, look no further than Michael. This hotel is the perfect choice for weary travelers in need of rest and rejuvenation. Not only does Michael offer a budget-friendly environment, but it is also conveniently located near great restaurants and attractions. With air-conditioned rooms and free wifi, staying connected and comfortable is a breeze. Plus, Michael is just a stone's throw away from popular landmarks like Greater Refuge Temple and General Grant National Memorial. If you're a fan of sushi, you'll be delighted to know that Michael is surrounded by fantastic sushi restaurants. And don't forget to explore the beautiful gardens nearby, such as Conservatory Garden, Shakespeare Garden, and Winter Garden. Your visit to New York City will be one to remember when you choose to stay at Michael. Amenities of Michael in New York City, USA When it comes to amenities, Michael in New York City, USA, has got you covered. With free internet and free wifi, staying connected is a breeze. Whether you're catching up on work emails or streaming your favorite shows, you can do it all without worrying about data limits. Plus, with air conditioning in every room, you can escape the summer heat and relax in comfort. So whether you're visiting for business or pleasure, Michael has the amenities you need for a comfortable stay. Contact of Michael in New York City, USA +1 212-740-1767 15 Sylvan Ter, New York City, NY 10032-5305 reservations@michaelny.com http://www.michaelny.com/ Location of Michael in New York City, USA Pictures of Michael in New York City, USA Tips for Staying in Michael
Book Michael Now !!! Tags |
2024.05.22 00:10 dradrado Is zero inhibiting cosmological understanding? One person's point of view.
When theorising in astrophysics, and more specifically the beginning and expansion of the universe (the big bang), the phenomenon of black holes and the mysteries behind dark matter and dark energy, we mistakenly use the two concepts interchangeably, they being 1. The philosophical zero, ie nothingness, and 2. The mathematics concept of zero, ie summarily attaching the philosophical concept of zero, with a numerical designation because it greatly assists the functionality of mathematic in the paradigm of our observable reality. Also please bearing mind the the math concept of zero allows negative values, unlike the philosophy, and when discussing space time, there is no place for negative numbers. Now that said and made clear, I believe it impossible for us to attempt to explain the unimaginable, without separation and distinction of the two concepts when infinity is brought into the conversation. Infinity, like zero, is a philosophical concept not all that dissimilar to zero, it has a mathematical conceptual basis also, but unlike the philosophical zero ie nothingness, it is given a numerical designation that more accurately relates to it philosophically, even though it is not strictly a number and cannot he used in any tangible calculation, mathematics certainly allows for its philosophical manifestation into mathematical equations.
I see this as a huge conflict, especially as it the very essence of big bang theory ie from nothing came infinity at the moment of the big bang. We surely cannot hope to solve this puzzle if the universe if we are conceptually flawed at he very starting point. 0 and infinity therefore cannot be used together in any calculation because we haven't yet reconciled the two conceptually. How can we look at this differently? How can we navigate passed mathematical dogma a concepts our brains are not capable of truly understanding on a practical level?
These are very tough existential and philosophical problems. So rather than just critise the current order and point out what I see as conflicts, but offer no alternative, may I suggest at least a starting point for discussion and exploration which may be found in the area of fractal science/mathematics. And a good place to focus the beginning of any theoretical discourse, in my opinion would be the work of, amoung others, Mandelbrot and the set named after him, the Mandelbrot Set. I suggest this because it mathematically the most relevant area of a field and is largely avoided by the popular culture's interest in fractals which is largely forcused on aesthetical beauty, particularly popular with the psychedelic subculture which I believe has a place and time to be investigated as a part of the whole discussion, but maybe for now should not be a point of focus in fear of contaminating a sterile discussion with with larger philosophically arguments about what is reality, due to the psychedelic substance insights of those schools. To incorporate any talk of altered states of consciousness, may be counter productive at this time. Hence my Mandelbrot suggestion achieves the mathematical parameters I believe are the best for theoretical mathematical support and cancels out the annoying noise that the fractal science field makes due to its attractiveness to non mainstream pop culture.
The Mandelbrot set is intriguing, not only because of the almost mindblowing graphical capability of AI, for as the Mandelbrot set seen by AI and then visualised for us to see, is nothing short of unbelievably beautiful. It also has an ability to provoke inner hought and discourse without one knowing the subject, topic or reason for the quiet peaceful internal discourse it inspires. I mention this, not because it can directly be incorporated in the radical discussion, but experiencing the astonishlng complexity if its beauty and the way it continues infinitely (or rather as long as it continues to be observed) because if the very self contained nature of the Mandelbrot set. After all, the mandelbrit set is simply a set of numbers, that when placed in the equation, do not spiral out into infinity. The equation value is always >0 or <2. So what as I see as irony, as the set was designed to avoid infinity in a sense, what it actually does is provide us with the best possible conceptualisation, in practice and theory, of a model demonstrating infinity. Even more bizarre is that the technology had only recently become available to show us visually by AI graphing. I'm not sure without the visual stimulus, could we have seen how beautifully fractal science demonstrates its potential unravelling existential and theoretical mysteries. I believe it lends itself perfectly to my proposed theory.
I think so because infinity is difficult for the human mind to grasp, some may say impossible. What is even more difficult for our minds to grasp is infinity of reducted values. Basically, if infinity can exist in an expanding sense, then it is not a stretch of conceptualisation to think it can infinitely get smaller. This breaks no rules of science. Searching for the building block of the universe has been crusade of quantum physicists dating back to the creation of the scientific theory. Much money and effort has been spent in search for smaller and smaller still subatomic particles. What they do is fractal science in its purest form, yet like with the study of Theoretical Astrophysics, quantum science theory is its self hampered by the concept if zero as a number, in my opinion. Even doing the work of factually reducing matter, they are blinded to its possible futility, should fractal reduction does forever decend in to fractal infinity or -ve infinity. For if that is the case, maybe quantum theory is in fact mankind's first exploration, albeit unknowingly, into what may well be a black hole. That is for a later discussion but certainly worth bringing to the attention for the purposes of this discussion.
So if we can accept that -ve infinity is as equally viable and logical as +ve infinity, what room in this discussion is left for the inclusion of zero?
I believe this leaves no room for zero in the same conversation as infinity. I am not suggesting zero should be stricken from mathematics. However I am suggesting that mathematics use of zero may, invalidate is ongoing use as an effective tool for measurement and communication, when the subject is beyond our ability to comprehend. Few people will argue that our 6 senses are significantly lacking the capacity to comprehend cosmological dynamics. Mathematics nothing more than an application of our 6 senses, to make sense of the chaos occurring all around us. Over hundreds and thousands of years, this is the best we have been able to do in terms of calculation and accurate prediction of future occurances. Even the concept of zero is less than 1000 years old. The Romans saw no use in incorporating it into their model, and to this day we wonder at their and other ancient civilisations ability for astonishing accuracy in measurement and prediction. Look at all they, the Egyptians and others managed without using zero in a single calculation. We can also break this down out of our conscious paradigm into nature. Numbers do not exist in nature (that includes the universe). It begs the question of do numbers really exist? Are numbers no more than part of our delusional reality? Who knows, but one thing is for sure, zero certainly doesn't exist anywhere outside of our consciousness. Not even in our own very bodies. How bodies clearly hold a knowledge that hasn't seemed to be passed over to our conscious, aware selves. Even on the smallest scale, without any intervention or guidance from any sort of intelligence, within our cellular membranes. Complex calculations are constantly being carried out. Consider cellular replication for example. In order for a cell to divide successfully, there must be a correct allocation of resources, let's just say primarily energy distribution for the sake of brevity. To split a cell but calculate the energy necessary to simply cary put the force of splitting. It must also calculate how much energy needs to be transfered to the new cell. This calculation must include how much energy for it take to replicate all cellular matter, how much energy is required for both cells to recover from the trauma, and how much energy on top of that, the new cell will require to become mature and begin its own replication. There are multiple complex calculations to be made there, and they then must be combined in to an overall and more complicated calculation again. All of this is done without intelligence and without using numbers ie mathematics. This same process can be observed all the way back to the very first beginning of not just life, but biochemistry in general. So I hope this demonstrates that the universe doesn't exist numerically. There are no rules in the universe. We created rules for our sciences, because if we didn't follow them the sciences would fail at unacceptable percentage of predictions.
So we make rules to overcome the shortcomings while waiting for future technologies or fixes. Mathematics and sciences are little more than a carefully ordered tapestry of rules, with too many exeptions for too many rules. We create rules and ideas to assist the conteived & malfunctioning intangible thing to not have to go to all the trouble of finding something that works better. We are just littered with examples through every field. Like 'zero', or Pi, or "bimdas" (brackets, indicies, multiply, division, addition and subtraction. I find this a good example, for not following this exact order of calculations, a correct answer to equation will nev a result) and thousands of others.
No rules exist in nature, it appears to be that it just is, always will be and always has been.
So in summary, given our restrictions on trying to understand the universe, namely intelligence, our 6 limited senses, our arrogance and our mortality, should we narrow the pursuits our restrictions can make us comfortable with? Thisbwilk lead us nowhere. By abandoning zero as the only accepted scientific approach to the universe, and allowing science to have multiple validating throeries for what is the same problem. The scientific community abhors divergence from dogma and academics are held to ransom with funding or being published, if their ideas are not with acceptable parameters.
But for the sake of this conversation, can we discuss the merits of looking at the big bang without reference to nothing ie zero, but instead +ve and -ve infinity."
submitted by dradrado to astrophysics [link] [comments]
I see this as a huge conflict, especially as it the very essence of big bang theory ie from nothing came infinity at the moment of the big bang. We surely cannot hope to solve this puzzle if the universe if we are conceptually flawed at he very starting point. 0 and infinity therefore cannot be used together in any calculation because we haven't yet reconciled the two conceptually. How can we look at this differently? How can we navigate passed mathematical dogma a concepts our brains are not capable of truly understanding on a practical level?
These are very tough existential and philosophical problems. So rather than just critise the current order and point out what I see as conflicts, but offer no alternative, may I suggest at least a starting point for discussion and exploration which may be found in the area of fractal science/mathematics. And a good place to focus the beginning of any theoretical discourse, in my opinion would be the work of, amoung others, Mandelbrot and the set named after him, the Mandelbrot Set. I suggest this because it mathematically the most relevant area of a field and is largely avoided by the popular culture's interest in fractals which is largely forcused on aesthetical beauty, particularly popular with the psychedelic subculture which I believe has a place and time to be investigated as a part of the whole discussion, but maybe for now should not be a point of focus in fear of contaminating a sterile discussion with with larger philosophically arguments about what is reality, due to the psychedelic substance insights of those schools. To incorporate any talk of altered states of consciousness, may be counter productive at this time. Hence my Mandelbrot suggestion achieves the mathematical parameters I believe are the best for theoretical mathematical support and cancels out the annoying noise that the fractal science field makes due to its attractiveness to non mainstream pop culture.
The Mandelbrot set is intriguing, not only because of the almost mindblowing graphical capability of AI, for as the Mandelbrot set seen by AI and then visualised for us to see, is nothing short of unbelievably beautiful. It also has an ability to provoke inner hought and discourse without one knowing the subject, topic or reason for the quiet peaceful internal discourse it inspires. I mention this, not because it can directly be incorporated in the radical discussion, but experiencing the astonishlng complexity if its beauty and the way it continues infinitely (or rather as long as it continues to be observed) because if the very self contained nature of the Mandelbrot set. After all, the mandelbrit set is simply a set of numbers, that when placed in the equation, do not spiral out into infinity. The equation value is always >0 or <2. So what as I see as irony, as the set was designed to avoid infinity in a sense, what it actually does is provide us with the best possible conceptualisation, in practice and theory, of a model demonstrating infinity. Even more bizarre is that the technology had only recently become available to show us visually by AI graphing. I'm not sure without the visual stimulus, could we have seen how beautifully fractal science demonstrates its potential unravelling existential and theoretical mysteries. I believe it lends itself perfectly to my proposed theory.
I think so because infinity is difficult for the human mind to grasp, some may say impossible. What is even more difficult for our minds to grasp is infinity of reducted values. Basically, if infinity can exist in an expanding sense, then it is not a stretch of conceptualisation to think it can infinitely get smaller. This breaks no rules of science. Searching for the building block of the universe has been crusade of quantum physicists dating back to the creation of the scientific theory. Much money and effort has been spent in search for smaller and smaller still subatomic particles. What they do is fractal science in its purest form, yet like with the study of Theoretical Astrophysics, quantum science theory is its self hampered by the concept if zero as a number, in my opinion. Even doing the work of factually reducing matter, they are blinded to its possible futility, should fractal reduction does forever decend in to fractal infinity or -ve infinity. For if that is the case, maybe quantum theory is in fact mankind's first exploration, albeit unknowingly, into what may well be a black hole. That is for a later discussion but certainly worth bringing to the attention for the purposes of this discussion.
So if we can accept that -ve infinity is as equally viable and logical as +ve infinity, what room in this discussion is left for the inclusion of zero?
I believe this leaves no room for zero in the same conversation as infinity. I am not suggesting zero should be stricken from mathematics. However I am suggesting that mathematics use of zero may, invalidate is ongoing use as an effective tool for measurement and communication, when the subject is beyond our ability to comprehend. Few people will argue that our 6 senses are significantly lacking the capacity to comprehend cosmological dynamics. Mathematics nothing more than an application of our 6 senses, to make sense of the chaos occurring all around us. Over hundreds and thousands of years, this is the best we have been able to do in terms of calculation and accurate prediction of future occurances. Even the concept of zero is less than 1000 years old. The Romans saw no use in incorporating it into their model, and to this day we wonder at their and other ancient civilisations ability for astonishing accuracy in measurement and prediction. Look at all they, the Egyptians and others managed without using zero in a single calculation. We can also break this down out of our conscious paradigm into nature. Numbers do not exist in nature (that includes the universe). It begs the question of do numbers really exist? Are numbers no more than part of our delusional reality? Who knows, but one thing is for sure, zero certainly doesn't exist anywhere outside of our consciousness. Not even in our own very bodies. How bodies clearly hold a knowledge that hasn't seemed to be passed over to our conscious, aware selves. Even on the smallest scale, without any intervention or guidance from any sort of intelligence, within our cellular membranes. Complex calculations are constantly being carried out. Consider cellular replication for example. In order for a cell to divide successfully, there must be a correct allocation of resources, let's just say primarily energy distribution for the sake of brevity. To split a cell but calculate the energy necessary to simply cary put the force of splitting. It must also calculate how much energy needs to be transfered to the new cell. This calculation must include how much energy for it take to replicate all cellular matter, how much energy is required for both cells to recover from the trauma, and how much energy on top of that, the new cell will require to become mature and begin its own replication. There are multiple complex calculations to be made there, and they then must be combined in to an overall and more complicated calculation again. All of this is done without intelligence and without using numbers ie mathematics. This same process can be observed all the way back to the very first beginning of not just life, but biochemistry in general. So I hope this demonstrates that the universe doesn't exist numerically. There are no rules in the universe. We created rules for our sciences, because if we didn't follow them the sciences would fail at unacceptable percentage of predictions.
So we make rules to overcome the shortcomings while waiting for future technologies or fixes. Mathematics and sciences are little more than a carefully ordered tapestry of rules, with too many exeptions for too many rules. We create rules and ideas to assist the conteived & malfunctioning intangible thing to not have to go to all the trouble of finding something that works better. We are just littered with examples through every field. Like 'zero', or Pi, or "bimdas" (brackets, indicies, multiply, division, addition and subtraction. I find this a good example, for not following this exact order of calculations, a correct answer to equation will nev a result) and thousands of others.
No rules exist in nature, it appears to be that it just is, always will be and always has been.
So in summary, given our restrictions on trying to understand the universe, namely intelligence, our 6 limited senses, our arrogance and our mortality, should we narrow the pursuits our restrictions can make us comfortable with? Thisbwilk lead us nowhere. By abandoning zero as the only accepted scientific approach to the universe, and allowing science to have multiple validating throeries for what is the same problem. The scientific community abhors divergence from dogma and academics are held to ransom with funding or being published, if their ideas are not with acceptable parameters.
But for the sake of this conversation, can we discuss the merits of looking at the big bang without reference to nothing ie zero, but instead +ve and -ve infinity."
2024.05.22 00:08 stanchochorbara UK mortgage decision - monthly outgoings
Hi everyone. I did read and answered some of my questions like could I get a mortgage with settled status and would have been in arranged overdraft an issue. Apparently from others experience both aint problem. I’ve only been into overdraft 20-80£ for few days in the past couple months due excessive travelling, thats like ever in my life.
I struggle to find information about share investing and private pensions. I have an annual income of 65-80k depending on overtime and I’m only looking into loan between 250-270k with 30k deposit. When they consider spendings I’ve been told money going into savings and pension are considered negative although they are positive spendings. I have about 900£ gross going into both, so its quiet a chunk. Most of my share schemes will be over next year and I’ll probably won’t renew them to be able to cope better with my budget, but I’m planning to apply for mortgage end of summer. Would that have a negative impact?
I do have a good credit history and by the time of my application I should NOT have any monthly dept outgoing towards loans/car.
Any helpful information about how they view different outgoings and what impact they could have would help me manage better the upcoming 3-4 months to try and give best impression to the bank. Thank you
submitted by stanchochorbara to UKPersonalFinance [link] [comments]
I struggle to find information about share investing and private pensions. I have an annual income of 65-80k depending on overtime and I’m only looking into loan between 250-270k with 30k deposit. When they consider spendings I’ve been told money going into savings and pension are considered negative although they are positive spendings. I have about 900£ gross going into both, so its quiet a chunk. Most of my share schemes will be over next year and I’ll probably won’t renew them to be able to cope better with my budget, but I’m planning to apply for mortgage end of summer. Would that have a negative impact?
I do have a good credit history and by the time of my application I should NOT have any monthly dept outgoing towards loans/car.
Any helpful information about how they view different outgoings and what impact they could have would help me manage better the upcoming 3-4 months to try and give best impression to the bank. Thank you
2024.05.22 00:06 MrDigitFace Help with Docker/NetApp Config Woes
I have inherited a Linux environment that had, until recently, mostly been managed by the devs using the systems. The company has since grown, as has the use-case for Unix based servers, so after expressing interest in the role I was promoted from Desktop Support to System Admin/Unix Admin to address the need a little less than a year ago. I have been trying to address some of the configuration sprawl and security issues as I learn, however, my current problem would really benefit from a second opinion from more experienced admins in this space.
Currently, I have several Ubuntu servers that are used by multiple users, with NFS shares mounted from NetApp NAS. The NetApp serves the same files/folders using both NFS and CIFS, with an NTFS security style, so all permissions are managed via NTFS ACLs, even when using NFS. To facilitate this, we currently have UNIX names manually mapped to Windows users in the NetApp config, so that Unix users can access files with NTFS ACLs. Additionally, these Linux servers are all domain joined, and users log in using their windows credentials.
Recently, we discovered that the root account is mapped to a privileged Windows user via the NetApp that we do not want it mapped to. The main issue is that our dev team members use Docker, and the containers access the NFS shares as root, so removing that mapping will break stuff in production. Subsequently, this highlighted another issue in our config; Docker users can volume bind local directories to the containers and effectively elevate to root without having been explicitly granted sudo permissions.
My current plan to address these issues is as follows:
• First, I plan on remapping container root a different id (ie. UID 300000) via userns remapping/subuid configs. This way Docker container root is no longer root in the host filesystem, and the remapped user’s access to the shares can be managed separately.
• Then I am going to create two shares, one for the users to access the data from the servers and one for applications to access data. Both will be CIFS shares (so no more NFS); the user share using the multiuser and sec=krb5 options and the application share mounted using a credential file with service account credentials, and then locked down with UNIX permission bits so that only the container user specified in the userns remap process has read/write access to the share.
Does this sound like an efficient solution to this problem? Is there a better way to approach this or other suggestions/considerations?
I had been pursuing using Kerberized NFS or a single CIFS share for both users and the application, but I ran into a few roadblocks. The biggest issue was that I could not figure out how to grant the containers on a given system a Kerberos ticket to access a Kerberized share (which is why I settled on a separate mount for applications using service account credentials). I was able to get as far as remapping the container root to a user (UID 300000) then grabbing Kerberos tickets on system boot for 300000 that is from a Windows service account with relevant access configured in the NTFS ACLs. When I tried to access Kerberized NFS shares as 300000 from the host it worked fine, but when I tried to run a container with that mount volume bound, I was denied access. My specific test case was that I ran an nginx container and shelled in as container root and tried to list/view/modify files from the Kerberized share. I confirmed on the host that root processes in the container were being mapped to 300000 on the host using Docker Top.
submitted by MrDigitFace to linuxadmin [link] [comments]
Currently, I have several Ubuntu servers that are used by multiple users, with NFS shares mounted from NetApp NAS. The NetApp serves the same files/folders using both NFS and CIFS, with an NTFS security style, so all permissions are managed via NTFS ACLs, even when using NFS. To facilitate this, we currently have UNIX names manually mapped to Windows users in the NetApp config, so that Unix users can access files with NTFS ACLs. Additionally, these Linux servers are all domain joined, and users log in using their windows credentials.
Recently, we discovered that the root account is mapped to a privileged Windows user via the NetApp that we do not want it mapped to. The main issue is that our dev team members use Docker, and the containers access the NFS shares as root, so removing that mapping will break stuff in production. Subsequently, this highlighted another issue in our config; Docker users can volume bind local directories to the containers and effectively elevate to root without having been explicitly granted sudo permissions.
My current plan to address these issues is as follows:
• First, I plan on remapping container root a different id (ie. UID 300000) via userns remapping/subuid configs. This way Docker container root is no longer root in the host filesystem, and the remapped user’s access to the shares can be managed separately.
• Then I am going to create two shares, one for the users to access the data from the servers and one for applications to access data. Both will be CIFS shares (so no more NFS); the user share using the multiuser and sec=krb5 options and the application share mounted using a credential file with service account credentials, and then locked down with UNIX permission bits so that only the container user specified in the userns remap process has read/write access to the share.
Does this sound like an efficient solution to this problem? Is there a better way to approach this or other suggestions/considerations?
I had been pursuing using Kerberized NFS or a single CIFS share for both users and the application, but I ran into a few roadblocks. The biggest issue was that I could not figure out how to grant the containers on a given system a Kerberos ticket to access a Kerberized share (which is why I settled on a separate mount for applications using service account credentials). I was able to get as far as remapping the container root to a user (UID 300000) then grabbing Kerberos tickets on system boot for 300000 that is from a Windows service account with relevant access configured in the NTFS ACLs. When I tried to access Kerberized NFS shares as 300000 from the host it worked fine, but when I tried to run a container with that mount volume bound, I was denied access. My specific test case was that I ran an nginx container and shelled in as container root and tried to list/view/modify files from the Kerberized share. I confirmed on the host that root processes in the container were being mapped to 300000 on the host using Docker Top.
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