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2024.05.17 10:27 utherpharmaceutical about semaglutide
Novo Nordisk recently announced the latest results of the STEP Phase 3a clinical trial project of semaglutide (semaglutide) 2.4 mg subcutaneous injection preparation for the treatment of obesity at the 2021 American Endocrine Society (ENDO 2021) Annual Meeting. Data from the STEP 4 trial showed that treatment with once-weekly subcutaneous (SC) 2.4 mg dose of semaglutide resulted in statistically significant weight reductions compared with placebo. submitted by utherpharmaceutical to FastingtoLoseWeight [link] [comments] Obesity is a chronic disease that requires long-term treatment and is associated with many serious health consequences and reduced life expectancy. There are many complications associated with obesity, including type 2 diabetes, heart disease, obstructive sleep apnea, chronic kidney disease, non-alcoholic fatty liver disease and cancer. Novo Nordisk is currently developing a once-weekly 2.4 mg subcutaneous formulation of semaglutide as a treatment for obesity in adults. Semaglutide is a glucagon-like peptide-1 (GLP-1) analog that can help people eat less, reduce calorie intake, and induce weight loss by reducing hunger and increasing satiety. The STEP program (Semaglutide in Obesity) is a global Phase IIIa clinical development program evaluating a once-weekly subcutaneous (SC) 2.4 mg dose of semaglutide for weight management in adults with obesity. The project includes a total of 4 phase IIIa trials, which have enrolled approximately 4,500 overweight or obese adults, and all trials have been successful. Based on data from the STEP clinical project, Novo Nordisk submitted a New Drug Application (NDA) for semaglutide 2.4mg subcutaneous injection to the US FDA in December 2020. The drug is injected subcutaneously once a week for long-term weight management. It is worth mentioning that Novo Nordisk also submitted a Priority Review Voucher (PRV) to speed up the NDA review. This PRV can shorten the NDA review cycle from the standard 10 months to 6 months. The indications applied for for semaglutide 2.4 mg subcutaneous injection preparation are: as an adjunct to a low-calorie diet and increased exercise, for the treatment of obesity (BMI ≥ 30 kg/m2) or overweight (BMI ≥ 27 kg/m2) accompanied by at least one body weight Adult patients with relevant comorbidities. STEP 4 (withdrawal) was a 68-week, randomized, double-blind, multicenter, placebo-controlled, withdrawal trial comparing semaglutide to placebo in 902 obese or overweight patients with comorbidities Efficacy and safety for sustained weight management. The trial includes a 20-week run-in period and a 48-week maintenance period. During the 20-week lead-in period, after receiving dose-escalating semaglutide treatment, 803 patients reached the target dose of 2.4 mg, and their average weight decreased from 107.2 kg to 96.1 kg. After that, these patients entered the maintenance phase and were randomly divided into 2 groups, one group received SC semaglutide 2.4 mg once a week, and the other group received SC placebo once a week for 48 weeks. Throughout the study, both treatment groups followed a regimen of low-calorie diet and increased physical activity. The trial used 2 statistical methods: (1) based on treatment strategy evaluation (primary statistical method), that is, without considering treatment compliance or the therapeutic effect of using other weight loss drugs; (2) based on trial product evaluation (secondary statistical method) ), that is, all patients adhere to the study drug treatment and do not use other weight loss drugs. The results showed that the STEP 4 trial met the two primary endpoints, and the data had statistically significant differences, showing that patients who continued to receive SC semaglutide 2.4mg further lost weight significantly, while patients who switched to placebo significantly regained their weight. ——The main statistical method showed that among all randomized patients, those who continued to receive SC semaglutide 2.4 mg for 48 weeks continued to reduce the average body weight by 7.9% from the baseline at randomization (weight at the end of the run-in period); while those who received placebo For patients, mean weight increased by 6.9% from baseline at randomization. The treatment difference between the 2 groups was statistically significant. Patients who received once-weekly SC semaglutide for 68 weeks (20-week lead-in period + 48-week maintenance period) experienced an average weight loss of 17.4%. ——Secondary statistical methods showed that among intention-to-treat patients, patients who continued to receive SC semaglutide 2.4 mg for 48 weeks continued to reduce mean body weight by 8.8% from baseline at randomization (weight at the end of the run-in period); For placebo patients, mean weight increased by 6.5% from baseline at randomization. The treatment difference between the 2 groups was statistically significant. Patients who received weekly SC semaglutide for 68 weeks experienced an average weight loss of 18.2%. In this trial, the safety profile of once-weekly subcutaneous injection of semaglutide 2.4 mg was consistent with that previously observed for GLP-1 receptor agonists and was well tolerated. The most common adverse events in patients treated with semaglutide 2.4 mg were gastrointestinal events. |
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Broker ticker,YF ticker,Listing country,Name,Currency,Type,Exchange,Sector,Industry,Last date (YYYY-MM-DD),Last price,Last price (EUR),Purchase date (YYYY-MM-DD),Purchase price,Purchase price (EUR),Quantity,Total cost,Total cost (EUR),Stop loss,Stop loss (EUR) 4BB.L,4BB.L,GB,4basebio PLC,GBp,EQUITY,LSE,Healthcare,Biotechnology,2024-05-15,1410,16.4411112956747,2024-05-15,1410,16.4411112956747,6,8460,98.6466677740485,181.99237928413,2.12076386322516 ABBN.VX,ABBN.SW,CH,ABB Ltd,CHF,EQUITY,EBS,Industrials,Electrical Equipment & Parts,2024-05-15,48.2000007629395,49.2463076080989,2024-05-15,48.2000007629395,49.2463076080989,2,96.4000015258789,98.4926152161979,30.0463815309176,30.6219409984699 ACGL.O,ACGL,US,Arch Capital Group Ltd.,USD,EQUITY,NMS,Financial Services,Insurance - Diversified,2024-05-15,97.8700027465821,90.0003736957321,2024-05-15,97.8700027465821,90.0003736957321,1,97.8700027465821,90.0003736957321,57.6807854724479,53.0540366273465 ADMA.O,ADMA,US,"ADMA Biologics, Inc.",USD,EQUITY,NGM,Healthcare,Biotechnology,2024-05-15,9.10000038146973,8.36827845079613,2024-05-15,9.10000038146973,8.36827845079613,12,109.200004577637,100.419341409554,1.47446989649493,1.35619824268739 AET.L,AET.L,GB,Afentra plc,GBp,EQUITY,LSE,Energy,Oil & Gas E&P,2024-05-15,51.5999984741211,0.601674693453668,2024-05-15,51.5999984741211,0.601674693453668,166,8565.5997467041,99.8779991133089,17.2552084436733,0.201075576151617 ALDNX.PAR,ALDNX.PA,FR,DNXCorp SE,EUR,EQUITY,PAR,Communication Services,Internet Content & Information,2024-05-15,22,22,2024-05-15,22,22,5,110,110,11.1928169792181,11.1928169792181 ALLAN.PAR,ALLAN.PA,FR,Lanson-BCC,EUR,EQUITY,PAR,Consumer Defensive,Beverages - Wineries & Distilleries,2024-05-15,46.5999984741211,46.5999984741211,2024-05-15,46.5999984741211,46.5999984741211,2,93.1999969482422,93.1999969482422,33.9247673647968,33.9247673647968 ALLOG.PAR,ALLOG.PA,FR,Logic Instrument S.A.,EUR,EQUITY,PAR,Technology,Computer Hardware,2024-05-15,1.16499996185303,1.16499996185303,2024-05-15,1.16499996185303,1.16499996185303,86,100.18999671936,100.18999671936,0.369989265252377,0.369989265252377 AROC.N,AROC,US,"Archrock, Inc.",USD,EQUITY,NYQ,Energy,Oil & Gas Equipment & Services,2024-05-15,20,18.39182,2024-05-15,20,18.39182,5,100,91.9591,9.52721949298871,8.76301263579761 ARRWU.O,ARRWU,US,Arrowroot Acquisition Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-04-16,17,15.633047,2024-04-16,17,15.633047,6,102,93.798282,8.8489792646162,8.13917609086355 ARYD.O,ARYD,US,ARYA Sciences Acquisition Corp IV,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.3699998855591,10.4557495647612,2024-05-15,11.3699998855591,10.4557495647612,10,113.699998855591,104.557495647612,10.6225484108966,9.77048193521333 BA_.L,BA.L,GB,BAE Systems plc,GBp,EQUITY,LSE,Industrials,Aerospace & Defense,2024-05-15,1363,15.8930742524856,2024-05-15,1363,15.8930742524856,6,8178,95.3584455149135,816.219675877841,9.51143778582399 BDB.MI,BDB.MI,IT,Banco di Desio e della Brianza S.p.A.,EUR,EQUITY,MIL,Financial Services,Banks—Regional,2024-05-15,4.98000001907349,4.98000001907349,2024-05-15,4.98000001907349,4.98000001907349,20,99.6000003814697,99.6000003814697,3.15504560196379,3.15504560196379 BDT.TO,BDT.TO,CA,Bird Construction Inc.,CAD,EQUITY,TOR,Industrials,Engineering & Construction,2024-05-15,22.5100002288818,15.1999072001158,2024-05-15,22.5100002288818,15.1999072001158,7,157.570001602173,106.39935040081,7.03762236613261,4.74895717230204 BPE.MI,BPE.MI,IT,BPER Banca SpA,EUR,EQUITY,MIL,Financial Services,Banks—Regional,2024-05-15,5.01200008392334,5.01200008392334,2024-05-15,5.01200008392334,5.01200008392334,20,100.240001678467,100.240001678467,2.09752578063009,2.09752578063009 BPSO.MI,BPSO.MI,IT,Banca Popolare di Sondrio S.p.A,EUR,EQUITY,MIL,Financial Services,Banks—Regional,2024-05-15,8.1899995803833,8.1899995803833,2024-05-15,8.1899995803833,8.1899995803833,12,98.2799949645996,98.2799949645996,3.57230683027942,3.57230683027942 BRBR.N,BRBR,US,"BellRing Brands, Inc.",USD,EQUITY,NYQ,Consumer Defensive,Packaged Foods,2024-05-15,58.9000015258789,54.1639113031845,2024-05-15,58.9000015258789,54.1639113031845,2,117.800003051758,108.327822606369,29.9543368800174,27.5516096558606 CAMT.O,CAMT,US,Camtek Ltd.,USD,EQUITY,NGM,Technology,Semiconductor Equipment & Materials,2024-05-15,100.389999389648,92.3177399287262,2024-05-15,100.389999389648,92.3177399287262,1,100.389999389648,92.3177399287262,13.0355686283783,11.9899465619902 CECO.O,CECO,US,CECO Environmental Corp.,USD,EQUITY,NMS,Industrials,Pollution & Treatment Controls,2024-05-15,25.1200008392334,23.1001266917515,2024-05-15,25.1200008392334,23.1001266917515,4,100.480003356934,92.4005067670059,9.5891733627488,8.81999699980263 CEU.TO,CEU.TO,CA,CES Energy Solutions Corp.,CAD,EQUITY,TOR,Energy,Oil & Gas Equipment & Services,2024-05-15,6.88000011444092,4.64572910763949,2024-05-15,6.88000011444092,4.64572910763949,22,151.3600025177,102.206040368069,1.86502711047414,1.25851223780441 CHG.FRA,CHG.F,DE,CHAPTERS Group AG,EUR,EQUITY,FRA,Technology,Information Technology Services,2024-05-15,23.2000007629395,23.2000007629395,2024-05-15,23.2000007629395,23.2000007629395,4,92.8000030517578,92.8000030517578,9.6013365799341,9.6013365799341 CIRC.MI,CIRC.MI,IT,Circle S.p.A.,EUR,EQUITY,MIL,Technology,Information Technology Services,2024-05-15,6.8600001335144,6.8600001335144,2024-05-15,6.8600001335144,6.8600001335144,15,102.900002002716,102.900002002716,4.30242335652391,4.30242335652391 CLS.TO,CLS.TO,CA,Celestica Inc.,CAD,EQUITY,TOR,Technology,Electronic Components,2024-05-15,70.8000030517578,47.8077949894401,2024-05-15,70.8000030517578,47.8077949894401,2,141.600006103516,95.6155899788802,3.54000015258789,2.38877681125436 COH.PAR,COH.PA,FR,Coheris SA,EUR,EQUITY,PAR,Technology,Software—Application,2024-05-15,6.73999977111816,6.73999977111816,2024-05-15,6.73999977111816,6.73999977111816,15,101.099996566772,101.099996566772,2.88333012866946,2.88333012866946 COOL.O,COOL,US,Corner Growth Acquisition Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.3699998855591,10.4557495647612,2024-05-15,11.3699998855591,10.4557495647612,10,113.699998855591,104.557495647612,10.3322166375254,9.5034385443796 CPH.TO,CPH.TO,CA,Cipher Pharmaceuticals Inc.,CAD,EQUITY,TOR,Healthcare,Drug Manufacturers—Specialty & Generic,2024-05-15,8.78999996185303,5.93545901158012,2024-05-15,8.78999996185303,5.93545901158012,17,149.429999351501,100.902803196862,1.96204830367043,1.32398171987155 CPRT.O,CPRT,US,"Copart, Inc.",USD,EQUITY,NMS,Industrials,Specialty Business Services,2024-05-15,55.310001373291,50.8625794728661,2024-05-15,55.310001373291,50.8625794728661,2,110.620002746582,101.725158945732,35.3170907446316,32.4842009447324 CRS.N,CRS,US,Carpenter Technology Corporation,USD,EQUITY,NYQ,Industrials,Metal Fabrication,2024-05-15,109.550003051758,100.741196856369,2024-05-15,109.550003051758,100.741196856369,1,109.550003051758,100.741196856369,34.0476120260581,31.3165509226119 DIS.MI,DIS.MI,IT,d'Amico International Shipping S.A.,EUR,EQUITY,MIL,Industrials,Marine Shipping,2024-05-15,7.69999980926514,7.69999980926514,2024-05-15,7.69999980926514,7.69999980926514,13,100.099997520447,100.099997520447,1.48521744342503,1.48521744342503 DNG.TO,DNG.TO,CA,Dynacor Group Inc.,CAD,EQUITY,TOR,Basic Materials,Other Precious Metals & Mining,2024-05-15,5.42000007629395,3.65986216555364,2024-05-15,5.42000007629395,3.65986216555364,27,146.340002059937,98.8162784699483,2.73996555376442,1.8489169198717 DRX.TO,DRX.TO,CA,ADF Group Inc.,CAD,EQUITY,TOR,Industrials,Metal Fabrication,2024-05-15,16.3299999237061,11.0268538824693,2024-05-15,16.3299999237061,11.0268538824693,9,146.969999313355,99.2416849422234,0.816499996185303,0.550970670396969 E.TO,E.TO,CA,"Enterprise Group, Inc.",CAD,EQUITY,TOR,Energy,Oil & Gas Equipment & Services,2024-05-15,1.21000003814697,0.817054113947654,2024-05-15,1.21000003814697,0.817054113947654,122,147.620004653931,99.6806019016138,0.210420134172571,0.141990597589385 ENO.MC,ENO.MC,ES,"Elecnor, S.A.",EUR,EQUITY,MCE,Industrials,Infrastructure Operations,2024-05-15,21.2000007629395,21.2000007629395,2024-05-15,21.2000007629395,21.2000007629395,5,106.000003814697,106.000003814697,12.551528826266,12.551528826266 ENVI.AS,ENVI.AS,NL,Envipco Holding N.V.,EUR,EQUITY,AMS,Industrials,Pollution & Treatment Controls,2024-05-15,5.80000019073486,5.80000019073486,2024-05-15,5.80000019073486,5.80000019073486,17,98.6000032424927,98.6000032424927,1.67603432587419,1.67603432587419 EVISO.MI,EVISO.MI,IT,eVISO S.p.A.,EUR,EQUITY,MIL,Utilities,Utilities—Regulated Electric,2024-05-15,4.90999984741211,4.90999984741211,2024-05-15,4.90999984741211,4.90999984741211,20,98.1999969482422,98.1999969482422,1.86293823453707,1.86293823453707 FTC.L,FTC.L,GB,Filtronic plc,GBp,EQUITY,LSE,Technology,Communication Equipment,2024-05-15,58.5,0.682131213331186,2024-05-15,58.5,0.682131213331186,147,8599.5,100.273288359684,2.925,0.0340851321595671 GAMC.O,GAMC,US,Golden Arrow Merger Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.0299997329712,10.1430884844427,2024-05-15,11.0299997329712,10.1430884844427,10,110.299997329712,101.430884844427,10.1468770873948,9.33296563558359 IDR.MC,IDR.MC,ES,"Indra Sistemas, S.A.",EUR,EQUITY,MCE,Technology,Information Technology Services,2024-05-15,20.1200008392334,20.1200008392334,2024-05-15,20.1200008392334,20.1200008392334,5,100.600004196167,100.600004196167,10.8941912325836,10.8941912325836 IGIC.O,IGIC,US,International General Insurance Holdings Ltd.,USD,EQUITY,NCM,Financial Services,Insurance—Diversified,2024-05-15,14.6700000762939,13.4904000401592,2024-05-15,14.6700000762939,13.4904000401592,7,102.690000534058,94.4328002811146,9.30404677312841,8.55774126931546 III.L,III.L,GB,3i Group Ord,GBp,EQUITY,LSE,,,2024-05-15,2966,34.5846355340222,2024-05-15,2966,34.5846355340222,3,8898,103.753906602067,1447.85882812435,16.8719519675262 IQG.L,IQG.L,GB,IQGeo Group plc,GBp,EQUITY,LSE,Technology,Software—Application,2024-05-15,472,5.50369115713367,2024-05-15,472,5.50369115713367,18,8496,99.0664408284061,114.359449092067,1.33263484991398 IVN.TO,IVN.TO,CA,Ivanhoe Mines Ltd.,CAD,EQUITY,TOR,Basic Materials,Other Industrial Metals & Mining,2024-05-15,19.9300003051758,13.4577588652472,2024-05-15,19.9300003051758,13.4577588652472,7,139.51000213623,94.2043120567304,8.61605916585422,5.81407950639264 JAM.L,JAM.L,GB,JPMorgan American Ord,GBp,EQUITY,LSE,,,2024-05-15,987,11.5087779069723,2024-05-15,987,11.5087779069723,9,8883,103.579001162751,734.693023539479,8.56140471933505 KKR.N,KKR,US,KKR & Co. Inc.,USD,EQUITY,NYQ,Financial Services,Asset Management,2024-05-15,107.669998168945,99.0123612861786,2024-05-15,107.669998168945,99.0123612861786,1,107.669998168945,99.0123612861786,51.1494689660835,47.0466166119071 KMER.MI,KMER.MI,IT,KME Group S.p.A.,EUR,EQUITY,MIL,,,2024-05-15,1.55999994277954,1.55999994277954,2024-05-15,1.55999994277954,1.55999994277954,64,99.8399963378906,99.8399963378906,0.800465071994058,0.800465071994058 KRNL.O,KRNL,US,"Kernel Group Holdings, Inc.",USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,10.9200000762939,10.0419337901592,2024-05-15,10.9200000762939,10.0419337901592,10,109.200000762939,100.419337901592,10.269285944972,9.44555571146799 KURN.VX,KURN.SW,CH,Kuros Biosciences AG,CHF,EQUITY,EBS,Healthcare,Medical Devices,2024-05-15,8,8.17366088441458,2024-05-15,8,8.17366088441458,12,96,98.083930612975,0.530445807104744,0.540606867796476 L.TO,L.TO,CA,Loblaw Companies Limited,CAD,EQUITY,TOR,Consumer Defensive,Grocery Stores,2024-05-15,155.139999389648,104.758488217297,2024-05-15,155.139999389648,104.758488217297,1,155.139999389648,104.758488217297,108.795430497776,73.4146865370985 LDO.MI,LDO.MI,IT,Leonardo S.p.a.,EUR,EQUITY,MIL,Industrials,Aerospace & Defense,2024-05-15,22.5,22.5,2024-05-15,22.5,22.5,4,90,90,9.15905866550776,9.15905866550776 LMB.O,LMB,US,"Limbach Holdings, Inc.",USD,EQUITY,NCM,Industrials,Building Products & Equipment,2024-05-15,50.6599998474121,46.5864799196816,2024-05-15,50.6599998474121,46.5864799196816,2,101.319999694824,93.1729598393631,3.1283030409755,2.87737246914973 MEMS.EQ,MEMS.PA,FR,"MEMSCAP, S.A.",EUR,EQUITY,PAR,Technology,Semiconductor Equipment & Materials,2024-05-15,7.75,7.75,2024-05-15,7.75,7.75,13,100.75,100.75,1.24829618687214,1.24829618687214 MEPK.N,MER-PK,US,Merrill Lynch Capital Trust I GTD CAP 6.45%,USD,EQUITY,NYQ,,,2024-05-15,25.3899993896484,23.3484149287262,2024-05-15,25.3899993896484,23.3484149287262,4,101.559997558594,93.3936597149048,23.4660902117283,21.5838047175749 MIKN.VX,MIKN.SW,CH,Mikron Holding AG,CHF,EQUITY,EBS,Industrials,Specialty Industrial Machinery,2024-05-15,16.9500007629395,17.3179447783545,2024-05-15,16.9500007629395,17.3179447783545,6,101.700004577637,103.907668670127,10.1066015477761,10.3002005739888 MLI.N,MLI,US,"Mueller Industries, Inc.",USD,EQUITY,NYQ,Industrials,Metal Fabrication,2024-05-15,59.0800018310547,54.3294379638214,2024-05-15,59.0800018310547,54.3294379638214,2,118.160003662109,108.658875927643,28.864001244309,26.5487331124992 MOD.N,MOD,US,Modine Manufacturing Company,USD,EQUITY,NYQ,Consumer Cyclical,Auto Parts,2024-05-15,109.419998168945,100.621645536179,2024-05-15,109.419998168945,100.621645536179,1,109.419998168945,100.621645536179,5.47099990844727,5.03215459279099 MSI.L,MSI.L,GB,MS INTERNATIONAL plc,GBp,EQUITY,LSE,Industrials,Conglomerates,2024-05-15,995,11.6020608079407,2024-05-15,995,11.6020608079407,9,8955,104.418547271466,299.053984032638,3.48488703199915 NBST.O,NBST,US,Newbury Street Acquisition Corporation,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,10.8400001525879,9.96836658031845,2024-05-15,10.8400001525879,9.96836658031845,10,108.400001525879,99.6836658031845,10.203750702138,9.38527724706745 NGEX.TO,NGEX.TO,CA,NGEx Minerals Ltd.,CAD,EQUITY,TOR,Basic Materials,Other Industrial Metals & Mining,2024-05-15,9.57999992370606,6.46890752273802,2024-05-15,9.57999992370606,6.46890752273802,15,143.699998855591,97.0336128410703,0.478999996185303,0.323227128293172 OCAX.O,OCAX,US,OCA Acquisition Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.1750001907349,10.2764296003981,2024-05-15,11.1750001907349,10.2764296003981,10,111.750001907349,102.764296003981,10.3482390933432,9.51817579094888 OPXS.O,OPXS,US,"Optex Systems Holdings, Inc",USD,EQUITY,NCM,Industrials,Aerospace & Defense,2024-05-15,8.56999969482422,7.8808945893631,2024-05-15,8.56999969482422,7.8808945893631,13,111.409996032715,102.45162966172,1.37396433534202,1.26375453411123 OSG.N,OSG,US,"Overseas Shipholding Group, Inc.",USD,EQUITY,NYQ,Energy,Oil & Gas Midstream,2024-05-15,6.8899998664856,6.33598186722136,2024-05-15,6.8899998664856,6.33598186722136,16,110.23999786377,101.375709875542,3.08423975967902,2.83684363583589 PLMI.O,PLMI,US,Plum Acquisition Corp. I,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.1199998855591,10.2258518147612,2024-05-15,11.1199998855591,10.2258518147612,10,111.199998855591,102.258518147612,10.3122527077106,9.48507598126697 PMGM.O,PMGM,US,Priveterra Acquisition Corp. II,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.0500001907349,10.1614807253981,2024-05-15,11.0500001907349,10.1614807253981,10,110.500001907349,101.614807253981,10.4066804048251,9.57192934951286 PNL.L,PNL.L,GB,Personal Assets Ord,GBp,EQUITY,LSE,,,2024-05-15,490,5.7135776843125,2024-05-15,490,5.7135776843125,18,8820,102.844398317625,205.388023341194,2.39339416053909 PSH.L,PSH.L,GB,Pershing Square Holdings Ord,GBp,EQUITY,LSE,,,2024-05-15,4058,47.3177515162043,2024-05-15,4058,47.3177515162043,2,8116,94.6355030324087,2760.24210472501,32.1652023698986 PUB.EQ,PUB.PA,FR,Publicis Groupe S.A.,EUR,EQUITY,PAR,Communication Services,Advertising Agencies,2024-05-15,106.150001525879,106.150001525879,2024-05-15,106.150001525879,106.150001525879,1,106.150001525879,106.150001525879,62.7854557332542,62.7854557332542 PUCK.O,PUCK,US,Goal Acquisitions Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,10.8500003814697,9.97756270079613,2024-05-15,10.8500003814697,9.97756270079613,10,108.500003814697,99.7756270079613,10.2216440084575,9.40173527760708 PWS.MI,PWS.MI,IT,Powersoft S.p.A.,EUR,EQUITY,MIL,Technology,Consumer Electronics,2024-05-15,16.2000007629395,16.2000007629395,2024-05-15,16.2000007629395,16.2000007629395,6,97.2000045776367,97.2000045776367,3.72774791732638,3.72774791732638 QDRO.O,QDRO,US,Quadro Acquisition One Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.0500001907349,10.1614807253981,2024-05-15,11.0500001907349,10.1614807253981,10,110.500001907349,101.614807253981,10.2946317689515,9.46886847086858 RDNT.O,RDNT,US,"RadNet, Inc.",USD,EQUITY,NGM,Healthcare,Diagnostics & Research,2024-05-15,58.2400016784668,53.556981383503,2024-05-15,58.2400016784668,53.556981383503,2,116.480003356934,107.113962767006,19.3818445183282,17.8271686239796 REAX.O,REAX,US,The Real Brokerage Inc.,USD,EQUITY,NCM,Real Estate,Real Estate Services,2024-05-15,5,4.597955,2024-05-15,5,4.597955,22,110,101.15501,0.25,0.22994675 RNWH.L,RNWH.L,GB,Renew Holdings plc,GBp,EQUITY,LSE,Industrials,Engineering & Construction,2024-05-15,1054,12.2900222025824,2024-05-15,1054,12.2900222025824,8,8432,98.3201776206592,681.809806634346,7.94515465532326 RR.FRA,RRU.F,DE,Rolls-Royce Holdings plc,EUR,EQUITY,FRA,Industrials,Aerospace & Defense,2024-05-15,4.94899988174439,4.94899988174439,2024-05-15,4.94899988174439,4.94899988174439,20,98.9799976348877,98.9799976348877,1.15474766444009,1.15474766444009 SAB.MC,SAB.MC,ES,"Banco de Sabadell, S.A.",EUR,EQUITY,MCE,Financial Services,Banks—Diversified,2024-05-15,1.90400004386902,1.90400004386902,2024-05-15,1.90400004386902,1.90400004386902,53,100.912002325058,100.912002325058,0.770675500087932,0.770675500087932 SLAM.O,SLAM,US,Slam Corp.,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,11.0500001907349,10.1614807253981,2024-05-15,11.0500001907349,10.1614807253981,10,110.500001907349,101.614807253981,10.3152097299573,9.48779581188824 SMHN.EQ,SMHN.F,DE,SÜSS MicroTec SE,EUR,EQUITY,FRA,Technology,Semiconductor Equipment & Materials,2024-05-15,51.2999992370606,51.2999992370606,2024-05-15,51.2999992370606,51.2999992370606,2,102.599998474121,102.599998474121,12.952163633103,12.952163633103 SOL.MI,SOL.MI,IT,SOL S.p.A.,EUR,EQUITY,MIL,Basic Materials,Specialty Chemicals,2024-05-15,33.7000007629395,33.7000007629395,2024-05-15,33.7000007629395,33.7000007629395,3,101.100002288818,101.100002288818,20.3776094280299,20.3776094280299 SPIE.EQ,SPIE.PA,FR,SPIE SA,EUR,EQUITY,PAR,Industrials,Engineering & Construction,2024-05-15,36.2200012207031,36.2200012207031,2024-05-15,36.2200012207031,36.2200012207031,3,108.660003662109,108.660003662109,24.4525122007507,24.4525122007507 TAYD.O,TAYD,US,"Taylor Devices, Inc.",USD,EQUITY,NCM,Industrials,Specialty Industrial Machinery,2024-05-15,51.3800010681152,47.2485865622292,2024-05-15,51.3800010681152,47.2485865622292,2,102.76000213623,94.4971731244583,5.60221111549934,5.15284095529179 TDW.N,TDW,US,Tidewater Inc.,USD,EQUITY,NYQ,Energy,Oil & Gas Equipment & Services,2024-05-15,108.110000610352,99.4169835712738,2024-05-15,108.110000610352,99.4169835712738,1,108.110000610352,99.4169835712738,8.89739581168513,8.18370900144243 TRD.L,TRD.L,GB,Triad Group plc,GBp,EQUITY,LSE,Technology,Information Technology Services,2024-05-15,277,3.22992044602972,2024-05-15,277,3.22992044602972,31,8587,100.127533826921,79.9188268645001,0.931297017338134 TRMD.O,TRMD,US,TORM plc,USD,EQUITY,NMS,Energy,Oil & Gas Midstream,2024-05-15,38.0400009155273,34.9812424819107,2024-05-15,38.0400009155273,34.9812424819107,3,114.120002746582,104.943727445732,15.7437186157142,14.4808677143919 TVK.TO,TVK.TO,CA,TerraVest Industries Inc.,CAD,EQUITY,TOR,Energy,Oil & Gas Equipment & Services,2024-05-15,78.879997253418,53.26382167953,2024-05-15,78.879997253418,53.26382167953,2,157.759994506836,106.52764335906,11.8947657049186,8.02653651594938 TWLV.O,TWLV,US,Twelve Seas Investment Company II,USD,EQUITY,NCM,Financial Services,Shell Companies,2024-05-15,10.8000001907349,9.93158297539806,2024-05-15,10.8000001907349,9.93158297539806,10,108.000001907349,99.3158297539806,10.1645252912436,9.34919822405708 UCG.MI,UCG.MI,IT,UniCredit S.p.A.,EUR,EQUITY,MIL,Financial Services,Banks—Regional,2024-05-15,36.2799987792969,36.2799987792969,2024-05-15,36.2799987792969,36.2799987792969,3,108.839996337891,108.839996337891,12.8251828408082,12.8251828408082 UNI.MI,UNI.MI,IT,Unipol Gruppo S.p.A.,EUR,EQUITY,MIL,Financial Services,Insurance—Diversified,2024-05-15,8.90499973297119,8.90499973297119,2024-05-15,8.90499973297119,8.90499973297119,11,97.9549970626831,97.9549970626831,4.53438024653025,4.53438024653025 URB.TO,URB.TO,CA,Urbana Corporation,CAD,EQUITY,TOR,Financial Services,Asset Management,2024-05-15,5.48000001907349,3.70037720566862,2024-05-15,5.48000001907349,3.70037720566862,27,147.960000514984,99.9101845530527,4.01565374986276,2.70974580401818 USAP.O,USAP,US,"Universal Stainless & Alloy Products, Inc.",USD,EQUITY,NMS,Basic Materials,Steel,2024-05-15,33.7299995422363,31.0178040090447,2024-05-15,33.7299995422363,31.0178040090447,3,101.189998626709,93.0534120271339,4.8737430358326,4.48280548569936 VCTR.O,VCTR,US,"Victory Capital Holdings, Inc.",USD,EQUITY,NMS,Financial Services,Asset Management,2024-05-15,52.1399993896484,47.9474741787262,2024-05-15,52.1399993896484,47.9474741787262,2,104.279998779297,95.8949483574524,27.0128366318881,24.8460559671344 VIL.EQ,VIL.PA,FR,"VIEL & Cie, société anonyme",EUR,EQUITY,PAR,Financial Services,Capital Markets,2024-05-15,10.75,10.75,2024-05-15,10.75,10.75,9,96.75,96.75,6.6231134232085,6.6231134232085 VIRC.O,VIRC,US,Virco Mfg. Corporation,USD,EQUITY,NGM,Consumer Cyclical,"Furnishings, Fixtures & Appliances",2024-05-15,12.539999961853,11.5316711049204,2024-05-15,12.539999961853,11.5316711049204,9,112.859999656677,103.785039944284,3.04456100600394,2.80034763402935 VRRM.O,VRRM,US,Verra Mobility Corporation,USD,EQUITY,NCM,Industrials,Infrastructure Operations,2024-05-15,27.3700008392334,25.1692064417515,2024-05-15,27.3700008392334,25.1692064417515,4,109.480003356934,100.676825767006,16.7701237135648,15.4249417801286 VRT.N,VRT,US,Vertiv Holdings Co,USD,EQUITY,NYQ,Industrials,Electrical Equipment & Parts,2024-05-15,104.599998474121,96.1892171968155,2024-05-15,104.599998474121,96.1892171968155,1,104.599998474121,96.1892171968155,5.22999992370606,4.81048593982583 W7L.L,W7L.L,GB,Warpaint London PLC,GBp,EQUITY,LSE,Consumer Defensive,Household & Personal Products,2024-05-15,485,5.65527587120727,2024-05-15,485,5.65527587120727,18,8730,101.794965681731,135.801416078837,1.58249887675333 WBDR.MI,WBDR.MI,IT,Webuild S.p.A.,EUR,EQUITY,MIL,Industrials,Engineering & Construction,2024-05-15,12,12,2024-05-15,12,12,8,96,96,4.99051752358873,4.99051752358873 X.TO,X.TO,CA,TMX Group Limited,CAD,EQUITY,TOR,Financial Services,Financial Data & Stock Exchanges,2024-05-15,36.4900016784668,24.6399215284378,2024-05-15,36.4900016784668,24.6399215284378,4,145.960006713867,98.559686113751,26.7457532329108,18.0479187481398 XPO.N,XPO,US,"XPO, Inc.",USD,EQUITY,NYQ,Industrials,Trucking,2024-05-15,114.059997558594,104.888547214905,2024-05-15,114.059997558594,104.888547214905,1,114.059997558594,104.888547214905,39.8781619915872,36.679414983756 XPS.L,XPS.L,GB,XPS Pensions Group plc,GBp,EQUITY,LSE,Consumer Cyclical,Personal Services,2024-05-15,262,3.05501500671403,2024-05-15,262,3.05501500671403,33,8646,100.815495221563,159.626440432165,1.86013275839029 YU_.L,YU.L,GB,Yü Group PLC,GBp,EQUITY,LSE,Utilities,Utilities—Diversified,2024-05-15,1735,20.2307291475147,2024-05-15,1735,20.2307291475147,5,8675,101.153645737573,86.75,1.01090092815126 ZYE1.FRA,ZYE1.F,DE,Addiko Bank AG,EUR,EQUITY,FRA,Financial Services,Banks—Regional,2024-05-15,18.7999992370605,18.7999992370605,2024-05-15,18.7999992370605,18.7999992370605,5,93.9999961853027,93.9999961853027,11.4772920878681,11.4772920878681 MINIMUM,,,,,,,,,,,0.601674693453668,,,0.601674693453668,1,,90,,0.0340851321595671 MAXIMUM,,,,,,,,,,,106.150001525879,,,106.150001525879,166,,110,,73.4146865370985 MEDIAN,,,,,,,,,,,12.1450111012912,,,12.1450111012912,8,,100.214999198914,,8.08285630340646 AVERAGE,,,,,,,,,,,26.0156541478769,,,26.0156541478769,14.55,,99.965850856796,,10.7737737301551 TOTAL,,,,,,,,,,,2601.56541478769,,,2601.56541478769,1455,,9996.5850856796,,1077.37737301551
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