Male muscle group

Heyo, I'm an aviation maintenance student (meaning I'm learning to maintain airplanes and helicopters) who is often alone when not at work or school, as such I'm not very social and I want to try and change that. I'd prefer women primarily because my friend groups are 95% male and I'd like a change of pace I guess you could say. We can talk about whatever the heck you feel like. Send me a message if you're interested and I'll get to it as soon as possible.
Edit: forgot to mention, my timezone is EST/EDT

Jack Layton once said “Canadians can get Parliament working again..if we...elect more New Democrats.” Few today would think that is the solution.
It’s clear Canadians want a third option. It’s also clear that they do not consider the current version of the NDP to be that option.
Under the leadership of Jagmeet Singh the party had it’s worst election performance since 2004 and the next election looks to be even more brutal.
Now is our chance to fix the NDP, return it to its roots, and give Canadians a real alternative to the CPC vs. Liberal, dichotomy.
Q: Why not support the PPC? A: It takes decades to build a party from scratch, even more to build a good reputation. It took nearly 3 decades for the Green Party to get a single seat. We don’t have that long.
Thanks to media defamation and poor candidate selection the PPC has a bad reputation.
Lastly, it’s easier for activists, us, to get change by voting in low-turnout elections than it is trying to get thousands of votes in federal elections.
Q: Why reform the NDP? A: The NDP has, or had, a solid pro-labour reputation. They have national recognition, and many folks have voted NDP once or twice in their lives.
Some of their policies, such as capping immigration to 1% of the population, are things we would agree on. The party is also hitting their lowest point as Singhs champagne socialism and the leaderships culture war message is turning off support for the party even though the alternatives don’t look good.
Q: When would the reform attempt happen? Short answer: organisation needs to start now. We need to be in place to flush out the opposition after the NDP utterly fails in the next federal election.
Long answer: Singh was re-elected with 82% of the delegate votes in 2023. It's unlikely any sort of attempt to oust him and the NDP leadership team would have any success before the next election in 2025. However it’s nearly guaranteed that they’ll fail badly and that is when we need to have organization in place to demand Singh and all the top brass resign.
An organised faction within the NDP will attract other disgruntled members helping us snowball support.
So to reiterate: the NDP is in a bad state. It’s gonna fail. Hard. The CPC will fail at improving Canadians lives and the time will be right for a real alternative. Now is the time to start organising, planning, and preparing for reform after the 2025 election. It’s time for us peasants to rise up. Time for us to have the Third Estate.
Q: How? A: The NDP constitution is a mess. It’s filled with rules like “this committee must be equally divided between female and male identifying members.” It’s also insane that international organisations are awarded delegates who can vote for party leaders and platforms. Yet despite this there is a path for reform.
Unlike the CPC, the NDP membership elects a representative for their district who then travels to the convention to vote on party platforms, policies, and the leadership.
Each district gets 1 delegate for the first 1-50 members in that district and then another for every 50 members after that. Anyone can be a member, including organisations (yes even international organisations) and their affiliated branches.
Other delegates are to labour organizations or student groups but the majority are from districts.
Last year there were about 65,000 delegates, which is a lot, so how can we make change?
Organization.
Voter turnout is never 100%. The last federal election had 62% turnout, the last city election in Kelowna (chosen randomly) had 30%, and the turnout number is lower the more granular you get.
How many registered NDP party members do you think are going to turn up to vote for a delegate who just travels to a boring NDP convention? I couldn’t find any data but my guess is not many. (If you have experience please let me know!)
All we’d have to do is make sure we have folks who want to be nominated and others who will vote for them in each district. We wouldn’t even have to control a majority of delegates. Remember, when the NDP collapses in 2025 there will be a huge push for reform. Show an organised movement and people will jump on board.
This is how you can make a serious impact. No marching, protesting, is necessary (though that would help.) You can stay home, live your life, stay anonymous, and then show up when it’s time to nominate a delegate and run or just cast a vote for one of us.
What do you think? Would you be interested in being a delegate or at least have time to show vote for our delegate sometime in 2025 or 2026?
P.S. do not join the NDP now. Do not give them your money or support. Organise outside the party and then join when it’s time to kick Singh out.
NDP policy: https://xfer.ndp.ca/2022/Documents/2021-POLICY.pdf
NDP constitution: https://xfer.ndp.ca/2023/Documents/Constitution%20EN-2021.pdf

Sexist NFL kicker Harrison Butker got outdone by successful woman entrepreneur Reshma Saujani and her POWERFUL commencement speech. Saujani is the founder of GirlsWhoCode, a group that teaches women to code so that they can gain a foothold in the male dominated computer coding industry.
If Butker’s deplorable speech went viral — Saujani’s powerful speech should go even more viral!

Ok, hear me out about this. For one, I am not saying that Yasuke's inclusion in Assassin's Creed Shadows at all is bad. That was hyperbole. Nor am i saying his role as a playable protagonist is bad.
However, i would like to observe the cultural circumstances surrounding, a) the issues that Asian men specifically face in Western media in particular, and b) the choice made here to have Yasuke in the male playable protagonist role, and what that means for representation of both Black and Asian people (i think solidarity is cool👍🏼), from a Japanese-American person's perspective.
Asian men (specifically men, keep this in mind, often of East, Southeast or South Asian descent) have a long history of being seen as weak, feminine, desexualized and unrelatable in Western media. This is why the inclusion of characters like Shang-Chi from the Marvel comics or Waymond Wang from Everything Everywhere All At Once are so important. Asian-American men being treated as strong, and as relatable characters, is an abnormality in media made in the West.
Counter-argument: "BUT WHAT ABOUT ANIME?" For one, I am talking about Western media specifically here (which is where AC Shadows is being made), but two, as this game will likely be consumed by Western audiences predominantly, I don't find the citation of anime, a foreign media, to be a very good counter-argument to my point here, because Asian-American people should not have to resort to looking to countries that are not their homes to provide representation for them. I've never been to Japan. I don't know how to speak the language. I find the idea that I *must* turn to foreign media for representation to be condescending.
Continuing from my first point, I find it to be, let's say, concerning, that when Ubisoft decided to make an Assassin's Creed game set in feudal Japan, and decided to keep the male protagonist/female protagonist split they've had since Assassin's Creed Syndicate, that they decided, for the first time in the series' history, to have a playable protagonist be an actual historical figure, conveniently taking the place of what would otherwise have gone to an Asian man, a group that has been historically under-represented in relatable protagonist roles in Western media.
And I would be less miffed about this decision had the female protagonist role also gone to a real person; at least then it would be consistent, but Naoe is not a real historical figure; this decision was made exclusively for Yasuke.
Now, let's make something clear; Yasuke's inclusion is not bad. Yasuke's inclusion as a playable protagonist is not bad. Yasuke is a very interesting historical figure and I cannot wait to see how Assassin's Creed Shadows will make his story fucking boring like this godforsaken series does with everything else explore this person. However, the fact that a game set in feudal Japan was unable to imagine an Asian man who would be relatable to a wide audience, and that this series set across the world at different times was unable to imagine an African protagonist in, say, pre-colonial Africa, is not an occurrence in a cultural vacuum.
Thank you for reading, please be civil.

I’m a male 20 years old and have just started my first cycle of anything with ostarine. I’m 2 weeks in and have been taking 10mg daily. I currently weigh 69kg quiet lean probably between 10-15% body fat and currently haven’t experienced major side effects however I have had abit of insomnia and i feel like it makes me wayyy hotter especially when working out. Looking to run this for 5 weeks, do u guys think I should have pct once I come off if I want to maintain gains and if so what do u recommend? And btw I’m not looking to put on massive amounts of muscle with this and become an animal I’m just looking for a slight boost in my training.

Demographics: Male, Asian
Intended Major(s): Biology/Chemistry
ACT/SAT/SAT II: 1570 SAT
UW/W GPA and Rank: 3.6GPA (no rank) -> will be ~3.8 after senior year, 3.7 after first sem
Coursework: 8 APS/3 DE/2 Honors, all 5s so far
Awards:

• 1st in Hosa states medical event (out of 50 teams)
• 2nd in Hosa Internationals (2nd/200+ teams who qualified), about 2000 teams overall
• AP Scholar w/ Distinction
• National Merit Finalist
• NHS Award
• School award for 5s on both Econ Tests
• School Honor Roll (shit award lol)

Extracurriculars:
Biotechnology and Research Sequencing at the University of Michigan (501c3 research organization) - Explored Nucleotide Hybridization, and led group research linking it to a real-world disease. Analyzed related Thermodynamics, PCR, Advanced Linux, and mapping genomes. Presented a business plan on Biotechnology and Next Generation Sequencing Technology (showing how genetic variation could lead to disease).
11th and 12th grade, 12hrs/wk, 4wk/yr
Medical Student Shadowing and Cardiac Medicine Exploration at the University of Brown Alpert Medical School - Completed a Medical Interview, a Cardiopulmonary Physical Exam with a patient, reviewed different medical careers, learned about the pathophysiology of the heart, and completed an ethics course on heart transplants.
11th and 12th grade, 10hrs/wk, 4wk/yr
Shadowed Primary Care Physician - Pediatrician has experience for 20+ years and ranked the #1 Care Physician out of 45 in my city. Worked in the Biomedical Lab analyzing samples and results for patients (in real-time). I shadowed the actual checkups as well
11th and 12th grade, 10hrs/wk, 3wk/yr
HOSA (Health Occupations Students of America) Competitor (all 50 states + 11 countries competed) (2yrs) - State Champion (1st out of 40 teams) in my 1st year, Only three teams are sent to ILC from Michigan, Qualified for ILC (International Leadership Conference), and placed Top 3 at ILC. Posted on 10+ nationwide news sites, as well as covered by the media. 260,000 members nationwide.
11th and 12th grade, 10hrs/wk, 30wk/yr
Co-Founder of Biomed Club (Only Student-Made Medical Club @ School) (4yrs) - Led in-school Biomedical-Based Medical Club focused on healthcare careers, connecting with licensed doctors and current medical students to inspire youth and teach them about the experience through the medical process. Expanded membership from 4 to 150 in 4 years by organizing talks for younger classmen about life as a doctor.
9th, 10th, 11th, 12th grade, 8hrs/wk, 35wk/yr
Joined SAT/Tutoring Help - Helps students increase their chances for college applications, as well as earn significant amounts of scholarship money. Was able to empower high school students through hackathons, college seminars, and a Cranbrook HUB Program which helped struggling students increase their SAT scores.
10th, 11th, 12th grade, 6hrs/wk, 10wk/yr
Swim Instructor (paid) - Worked for ~1 year, over 400 hours of work, about 8-10 hours weekly on school weeks, and closer to 15 hours during summer, CPR and Lifeguard Certified. Had several classes, weekly, with kids with disabilities, such as Down Syndrome, Autism, and ADHD.
11th, 12th grade, 8-10hrs/wk, 40wk/yr
Swim Instructor Summer Volunteer connected w/Hospital's Children’s Care Center (most vulnerable kids) - Instructed and taught children who have been impaired with neurological, social, and developmental challenges, as well as kids that have dealt with major trauma at a very young age to swim. Participated in a 3-week long program teaching them the basics of swimming.
11th, 12th grade, 8-10hrs/wk, 4wk/yr
Michigan Ref Certified - Participated in overall 50+ hours of ref-related activities, played soccer for 13 years and competed in competitive/travel soccer for 10 years.
9th, 10th, 11th, 12th grade, 2hrs/wk, 13wk/yr (for reffing)
9th, 10th grade, 8hrs/wk, 50wk/yr (for soccer)
VolunteeTutor Work - Volunteer Monthly at an Indian Cultural Program (10hrs/month), Math Tutor for struggling students (3hrs/week), Volunteer Monthly for Key Club (3hrs/month)
Essays/LORs/Other:
APES (7/10)
STEM Teacher (9/10)
Schools (in state for MSU/UMich):
MSU
UMich (EA)
Rice
JHU
BU
UPenn (ED)
Columbia
Chance Me: MID GPA UPENN

Hi guys. New to the group. I have been working out for anwhile but just cant the routine that works for me. I do between 4 and 5 days and am looking for routine that works specifically for groups. I have done the whole push pull thing and its ok but i feel like i need more… what do u recommend? Im 40 and looking to build muscle but also get defined

Figured a single post would be better than annoying everyone with a series of 'em, so here you go. List is newest to oldest.
Fair warning: Absurdist Humor & Satire are my bread and butter, but I make "real" stuff on rare occasions too. It's all just a creative outlet for the vitriol that builds up in my system over the work week. Let me have my fun.
Still Just A Frog

• Prompt: adult alternative pop/rock, college rock, melodic (Manual Mode)
• Song Type: Social/Political Commentary
• Notes: A ditty for folks still living in their fantasy land in 2024

I Don't Love You That Much (Based On A True Story)

• Prompt: male vocalist, chicago blues, electric blues
• Udio Used: Blues, Electric blues, Chicago blues, Instrumental
• Song Type: HumoSatire
• Notes: "Every relationship's got boundaries, but this is too far over the line."

Take 3.8 (Shrinkflation)

• Prompt: bebop, hard bop, cool jazz, drums (drum set), alto saxophone, double bass, piano, 5/4 time, instrumental jazz, cool jazz
• Udio Used: Piano, Cool jazz, Bebop, Double bass, Hard bop, Big band, Jazz, Swing, Uncommon time signatures, Improvisation, Rhythmic, Instrumental
• Song Type: Instrumental/Bebop Jazz Quartet
• Notes: An experiment with command tags to see if I could get something similar to Paul Desmond's "Take Five" (the title's a send-up to that song.) The commands were mostly ignored by the AI, but I still really liked the results.

Shake Your Cans, I Dare Ya!

• Prompt: 1960s, early rock and roll, rhythm & blues, soul, male vocal trio with baritone and bass and tenor voices, bouncy, fun, happy, moderate tempo, piano, drums, trumpet, saxophone, trombone, upright bass, harmonica, guitar
• Udio Used: Jazz, Rhythm & blues, Soul, Happy, Playful, Vocal jazz, Energetic, Guitar, Trombone, Bass, Fun, Piano, Trumpet, Drums, Saxophone, Bebop
• Song Type: HumoSatire
• Notes: This one's still a WIP, providing I get the nerve up to continue struggling with it. It's missing the 2nd pre-chorus, which contains the core "snark" of the song ("Quit your whimpering and dance, dammit!"). Beware Udio's use of Jazz prompts! It adds syncopation to the music which can be a pain to work with in a song with pop-style lyrics.

Your Anime Waifu Isn't Real, G*d Dammit!

• Prompt: 1960s, early rock and roll, rhythm & blues, soul
• Udio Used: R&b, Doo-wop, Rhythm & blues, Soul, Doo wop, Early rock and roll
• Song Type: HumoSatire
• Notes: Just what it says on the tin.

Blasphemy in what was supposed to be Barbershop...

• Prompt: barbershop, a capella, barbershop quartet, male vocal quartet, barbershop
• Udio Used: Male vocalist, Pop, Melodic, Love, Vocal group, Uplifting
• Song Type: HumoAbsurdist
• Notes: Udio seems unable to produce a Barbershop Quartet song, even though there's a Barbershop prompt. Should have Bass, Baritone, Low-Tenor and Tenor vocalists, but it kept dropping the Bass and Baritone for Countertenor and Soprano/Falsetto, like you hear in Doo-wop. Took too long futzing with this for a joke song, so I went with what ending up sounding best.

The Bingo Hall Gooners - Yo-Da-Lay-Dee! (Pinch A Booty!)

• Prompt: classic bluegrass, 1930's bluegrass, traditional bluegrass, male vocal trio, mandolin, fiddle, banjo, in the style of the "man of constant sorrow"
• Udio Used: Northern american music, Regional music, Country, Progressive bluegrass, Bluegrass
• Song Type: HumoAbsurdist
• Notes: A Bluegrass tune about a pervert getting pepper-sprayed. Because why the hell not?

So my body is asking me to masterbate to a random girl in a porn video rn, I'm holding myself for long but right now my brain is tempting me to go bond with a porn video and me not doing so gave me a feeling of tightness in the chest!
I get that my body is wanting me to go mate, but I'm in a place where actually mating is not accessable, and for.so long porn was my way of tricking myself into feeling that i have bonded with a women and secured a relationship.
Before an hour ago I saw to girls from my neighbors going out looking all ready for a fun night at 1 am, I really wanted to go out where they are going because I felt I would meet someone out there, but I'm a guy who spends all his time at home, and I don't have anyone to show me where I can go to meet girls, for context I live in Saudi Arabia, meeting with girls in general is hard but some people know how to go and have private meetings, like secret clubs.
Nevertheless it got me thinking that I need someone, masterbating to porn is like bonding, making a bonding, because sex and orgasm is a way of establishing bond between to people, so now me need to make a bond is very related to watching porn.
God as I'm writing I'm wondering what the fuck am I doing here! I'm a Saudi kid living in a Saudi community, what tf am I doing in a western community group!!! This is absolutely pointless, you guys will never be able to help find girls, what I should do is mingle more with Saudis instead someone must have figured it all out and would help go into a private party where I can meet girls. I'm 26 and the only way to have a girl is that I either make money and marry a girl from her family, or marry a cousin, which I don't have!
Otherwise I need to be in a place where there is a lot of casual meetings between boys and girls, which is mostly a workplace but I'm still a student in an all male college FUCK I NEED A WOMEN! TIRED OF THE FAKE SHIT

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Navajo Skinwalkers
In the Navajo culture, a skinwalker is a type of harmful witch who has the ability to turn into, possess, or disguise themselves as an animal.
This witch is called “yee naaldlooshii” by the Navajo, which translates to “with it, he goes on all fours.”
It is just one of several types of Navajo witches and is considered the most volatile and dangerous.
For the Navajo people, witchcraft is just another part of their spirituality and one of the “ways” of their lives.
As such, witchcraft has long been part of their culture, history, and traditions.
Witches exist alongside humans and are not supernaturals.
The Navajo believe there are places where the powers of both good and evil are present and that those powers can be harnessed for either.
Medicine men utilize these powers to heal and aid members of their communities, while those who practice Navajo witchcraft, seek to direct the spiritual forces to cause harm or misfortune to others.
This type of Navajo witchcraft is known as the “Witchery Way,” which uses human corpses in various ways such as tools from the bones, and concoctions that are used to curse, harm, or kill intended victims.
The knowledge of these powers is passed down from the elders through the generations.
The Navajo are part of a larger culture area that also includes the Pueblo people, Apache, Hopi, Ute, and other groups that also have their own versions of the Skinwalker, but each includes a malevolent witch capable of transforming itself into an animal.
Among these tribes, a number of stories and descriptions have been told throughout the years about the Skinwalkers.
Sometimes, these witches evolved from living their lives as respected healers or spiritual guides, who later chose to use their powers for evil.
Though they can be either male or female, they are more often male.
They walk freely among the tribe during the day and secretly transform under the cover of night.
In order to become a Skinwalker, he or she must be initiated by a secret society that requires the evilest of deeds – the killing of a close family member, most often a sibling.
After this task has been completed, the individual then acquires supernatural powers, which gives them the ability to shape-shift into animals.
Most often, they are seen in the form of coyotes, wolves, foxes, cougars, dogs, and bears, but can take the shape of any animal.
They then wear the skins of the animals they transform into, hence, the name Skinwalker. Sometimes, they also wore animal skulls or antlers atop their heads, which brought them more power.
They choose what animal they wanted to turn into, depending on the abilities needed for a particular task, such as speed, strength, endurance, stealth, claws, and teeth, etc.
They may transform again if trying to escape from pursuers.
Because of this, the Navajo consider it taboo for its members to wear the pelt of any predatory animal. However, sheepskin, leather, and buckskin are acceptable.
The skinwalkers are also able to take possession of the bodies of human victims if a person locks eyes with them.
After taking control, the witch can make its victims do and say things that they wouldn’t otherwise.
Once they were shape-shifted, one way that others could tell that they were not a real animal is that their eyes are very different than those of the animal.
Instead, their eyes are very human, and when lights are shined on them, they turn bright red.
Alternatively, when they are in human form, their eyes look more like animals.
The evil society of the witches gather in dark caves or secluded places for several purposes – to initiate new members, plot their activities, harm people from a distance with black magic, and perform dark ceremonial rites.
These ceremonies are similar to other tribal affairs, including dancing, feasts, rituals, and sand-painting, but were “corrupted” with dark connotations.
The evildoers are also said to engage in necrophilia with female corpses, commit cannibalism, incest, and grave robberies.
During these gatherings, the Skinwalkers shape-shift into their animal forms or go about naked, wearing only beaded jewelry and ceremonial paint.
The leader of the Skinwalkers is usually an old man, who is a very powerful and long-lived Skinwalker.
Skinwalkers also have other powers including reading others’ minds, controlling their thoughts and behavior, causing disease and illness, destroying property, and even death.
Those who have talked of their encounters with these evil beings describe a number of ways to know if a skinwalker is near.
They make sounds around homes, such as knocking on windows, banging on walls, and scraping noises on the roof.
On some occasions, they have been spied peering through windows.
More often, they appear in front of vehicles in hopes of causing a serious accident.
It is said that, in addition to being able to shapeshift, the Skinwalker is also able to control the creatures of the night, such as wolves and owls, and to make them do its bidding.
Some are able to call up the spirits of the dead and reanimate the corpses to attack their enemies.
Because of this, you shouldn't ventured out alone.
Its supernatural powers are uncanny, as they are said to run faster than a car and have the ability to jump high cliffs.
They are extremely fast, agile, impossible to catch and leave tracks that are larger than those of any animal. When they have been seen, they have been described as not quite human and not fully animal.
They are usually naked, but some have reported seeing the creature wearing tattered shirts or jeans.
The Skinwalker kills out of greed, anger, envy, spite, or revenge.
It also robs graves for personal wealth and to collect much-needed ingredients for use in black magic.
These witches live on the unexpired lives of their victims and they must continually kill or perish themselves.
Skinwalkers and other witches have long been blamed for all manner of unexpected struggles and tragedies through the years, including sickness, drought, poor crops, and sudden deaths.
Even smaller or individual problems such as windstorms during dances, alienation of affection by mates, the death of livestock, and reversal of fortune, were often believed to be the work of a witch.
This was most apparent with the Navajo Witch Purge of 1878, which initially evolved from a cultural response to so many people moving across and onto their lands.
After a series of wars with the U.S. Army, the Navajo were expelled from their land and forced to march to the Bosque Redondo (Fort Sumner) in New Mexico in what is known as the Long Walk of the Navajo in 1864.
There, the people suffered from bad water, failed crops, illness, and death, reducing their numbers dramatically.
After four years, the government finally admitted they had made a mistake and the Navajo were allowed to return to their homeland in the Four Corners area.
During these years, many of the tribe’s members were said to have turned to shape-shifting to escape the terrible conditions.
In the meantime, the rest of the tribe were convinced that their gods had deserted them.
Once the people had returned to their homeland, their conditions improved, but the dreaded skinwalkers, for whom they blamed for their years on the bleak reservation, were still among them.
Accusations of witchcraft and the hunting of the skinwalkers began.
When someone found a collection of witch artifacts wrapped in a copy of the Treaty of 1868, the tribal members unleashed deadly consequences.
The “Navajo Witch Purge” occurred in 1878, in which 40 Navajo suspected witches were killed in order to restore harmony and balance for the tribe.
Today, most of the tales of sightings of these witches do not include death or injury, but rather, are more “trickster-like.”
Numerous people have told stories of swift animals running alongside their vehicles, matching their speed. After a short period, however, they run off into the wilderness.
Along the way, these animals sometimes turn into a man, who sometimes bangs on the hood.
Another story tells of a man who was making repairs on an old ranch home when he began to hear loud laughter coming from the nearby sheep pens.
Thinking he was alone, he went to investigate and found all of the sheep but one huddled in one corner of the pen.
However, there was a lone ram separated from the group that was standing upright and laughing in a very human manner.
After the man locks eyes with the ram, he sees that his eyes are not that of an animal, but very like a human’s. The animal then casually walked away on all four legs.
Some say they have seen them running through the night, sometimes turning into a fiery ball, leaving streaks of color behind them.
Others have seen angry-looking humanoid figures looking down on them from cliffs, mountains, and mesas.
In the 1980s one of the most notable events occurred when a family was driving through the Navajo Reservation.
As they slowed to make a sharp curve, something jumped from the ditch.
It was described as black, hairy, and wore a shirt and pants.
A few days after this event, at their home in Flagstaff, Arizona, the family was awakened to the sounds of loud drumming and chanting.
Outside their home were three dark forms of “men” outside their fence.
However, these shadowy creatures were seemingly unable to climb the fence and soon left.
These events have occurred in the Four-Corners area of southwest Colorado, southeast Utah, northeast Arizona, and northwest New Mexico.
In the 1990s, a ranch in northeast Utah, far away from the Navajo Reservation, became the partial focus of the Skinwalkers.
Called the Sherman Ranch, the Skinwalker Ranch, and the UFO Ranch, this place has a history of UFOs, aliens, cattle mutilations, and crop circles.
Located near the Ute Indian reservation, these people have long thought that the Navajo put a curse on their tribe in retribution for many perceived transgressions and since then, the skinwalkers have plagued the Ute people.
Witchcraft represents the antithesis of Navajo cultural values and is not tolerated.
They work to avoid it, prevent it, and cure it in their daily behaviors.
However, when it exists, their laws have always said that when a person becomes a witch, they have forfeited their humanity and their right to exist, so they should be killed.
However, skinwalkers are notoriously hard to kill and attempts are usually unsuccessful.
Trying to kill one will often result in the witch seeking revenge.
Successful killing generally requires the assistance of a powerful shaman, who knows spells and rituals that can turn the Skinwalker’s evil back upon itself.
Another alternative is to shoot the creature with bullets that have been dipped into white ash.
However, this shot must hit the witch in the neck or the head.
Traditionally, the Navajo will not speak with outsiders about these creatures, for fear of retribution by the skinwalkers.
For that matter, it is a taboo subject amongst the natives themselves.
“These are not things that need or should be discussed by outsiders.
At all.
I’m sorry if that seems ‘unfair,’ but that’s how our cultures survive.” – Dr. Adrienne Keene, Native American academic, writer, and activist

Sort of silly question but I wanted to know if anyone who has been through boot camp can tell me how the showers are set up? Is it a group shower and we have a set time to shower or is it kind of left up to you to do during whatever free time you get? I’m a female but males can answer too I’m sure it’s sort of the same regardless

Male or female doesn’t matter but 19+ and I’m just looking for cool people to hangout with. Probably just be friends online first and if we get along then eventually meet in person. I got some friends but just looking to meet more people. I’m down to introduce you to my friend group if we get along. I’m into playing guitar or videogames or sports. I’m an engineering college student. I like to go out and just have fun spontaneous experiences. I love nature and hiking or trying different restaurants. I’m a chill person. I also enjoy deep convos. lmk if ur interested thanks.

Hi ladies on rails! I can't help but notice that there are a great deal more guys than ladies in the rails development world. Or maybe even development in general. I sometimes wonder if this is because it's intimidating to get into something so male dominated.
Surfing is another very male dominated activity. I have surfed for many years and it wasn't until I found a really good group of girls to surf with that I felt more confident in the water. Thanks to a non profit organization called Bitches and Barrels, I was able to find the community of girls that helped me gain more confidence.
So I had the idea, that maybe I could run a code camp for women. We would learn how to build a rails app from scratch together. Is there any interest for something like that out there?
Would love to get your thoughts!

Hello everyone! I wanted to write and share something constructive for this space, that hopefully goes beyond snarking specific names and personalities and helps those who have been harmed in one way or another find a bit of understanding around what happened to them and why.
I've shared pieces of my story here before but the gist is: I am not from the coaching world. I'm from the general spirituality world - from a spiritual modality that has an aspect of divine feminine and divine masculine that has always interested me, but few others in the community. I learned about this whole specific mess listening to love & light confessionals, and went deep into the rabbit hole. The perversion of understanding of masculine/feminine energy dynamics was horrifying but also enlightening. I'm big on learning how NOT to be from people who give me the major ick. This is why I've done a lot of deep diving in general on cults, gurus, and manipulative spirituality in general - and there's a lot to take away if you can go in with this mindset. I'm also hella autistic and love infiltrating niche internet subgroups whose experiences are much different than mine so I can - again - learn from the experieneces of others, and gain more empathy and understanding of the vast human experience.
I was a very forward facing person for the nonprofit I volunteered for for over 4 years. There was no "guru" that I supplicated, however there was a person formally in charge who abused their power and the willingness of others to help the organization, and was known to be cruel in private, when it suited them. I didn't see this person as above me - in fact in a lot of ways they were quite pitiful and needed a lot of help/support in their role - which is what I did, willingly and for practically free. At one point, the entire org sat down and did a call in of this person, however, they were able to push everyone that they couldn't control out of the way and rewrote the story with themselves as the victim (we all know this one). The final falling out happened at the end of 2019, so luckily for them Covid gave them some time to figure out how to run their events without me (they hired a paid staff).
Anyway, I gave many many hundreds of hours to this cause, and then the person in charge was able to take advantage of me and then push me out of the community I had served very seriously for 6 years with rumors that I had been trying to steal money. This is so far beyond the truth, and everyone involved directly knows this, but no one came to dispell the rumor. So, I've been heartbroken by supposedly "spiritual" leaders of a community, that's for sure. In fact listening to Katya was part of the cult deprogramming that me and a group who had left together went through (this group also used, abused, and betrayed me but that's another story!)
So, this isn't going to be about me, I just wanted to share my background. This is about what the divine feminine and the divine masculine "REALLY" are. This may get a bit woo in here but I can't imagine anyone here is afraid of woo. In fact it's the mystery of the spiritual experience that allows these people to cause so much harm. So let me try to remove some of that mystery.
The creation is polarized, in many ways. One of those ways is masculine/feminine. The masculine force is the will, the conscious mind, and that which puts the infinity of possible experience into order. It in and of itself is quite fallible. The feminine force is the subconscious mind - all that is - and the untapped potential of this reservoir. The masculine reaches for the feminine, and if the will (masculine) is properly configured, the unmanifest creation (feminine) will give him something in return. The masculine NEEDS the feminine but the feminine doesn't really NEED the masculine, however it does desire the masculine's attention being focused it its direction (instead of random mundane wordly experiences). And the feminine wants the masculine's attention consistently, lest the feminine will not be consistent at all in its response. This attention can be forceful or gentle, but it must be consistent.
Every human has a balance of masculine/feminine energy in them, and while women are socially conditioned to tend towards feminine expression and men towards masculine, biological sex really has very very little to do with it. There are of course, positive feminine expressions and negative, and positive male expressions and negative. What these polarity goons do is mostly focus on a mix of positive/negative masculine expression for the man, 0 female expression, and then only positive feminine expression for the woman with maybe, possibly, a bit of positive masculine expression (only during working hours when you're in seperate offices, and only if you're paying the bills, ofc)
Typically, we are attracted to partners who "balance" out our spiritual energy - so the "polarization" in a relationship can be anywhere from hyper masc/hyper femme to barely masc/barely femme - and again, this is NOT a hard and fast rule and has almost NOTHING to do with sex other than a general (mostly cultural) bias. The hyper femme/hyper masc scenario can definitely be more, well, exciting and dramatic than a relationship between two people who have very little polarized charge in that way between them. But that's likely why few of these polarity gurus have any experience in longevity of relationships - they are fueling their "twin flame" relationship with manufactured drama and trauma bonding. In reality, in a relationship, you are supposed to grow together and be more willing to meet each other where you are at in the moment, instead of demanding they be a near perfect idealized form before you offer them any attention/respect.
The reason these male teachers push polarity doctrine is literally because of their own wounding of the expression of the masculine/feminine. Men (especially USian men) have been taught that expressing any aspect of their feminine selves is repulsive and weak and probably gay. So, their solution to their own inability to be vulnerable is to attack women - for being "too masculine" - aka some balanced expression of both, normal! They want their women to be 100% pure unformed childlike energy with no will of their own, just a will that can be given to the man. They want them to embody this feminine space as close to 100% of the time so that they are forced into their masculine 100% of the time. Girlies, if you are in your masculine, this makes them feel more in their feminine and - gosh that's just icky and disgusting. You don't want your man to get a boner for you when you're in the masculine - that might make him GAY! In the very least it's totally beta to be attracted to a masculine woman and basically gay anyway. No thanks!
I'm sorry to be facetious, but this is in general a lot of the subconscious and even sometimes conscious thought processes behind these hyper polarity relationships. These are not evolved, embodied people. These are people who are still very invested in the old fashioned human status quo that has served them for a long time. We had the thread a few weeks back with the Desire on Fire lady (ugh her name escapes me) talking about how her husband had to "put her in her place" for being "too masculine" and how he really just "didnt want her" when she was in her masculine, when she was literally just running her business. Masculine wounding almost ALWAYS shows up as men being jealous of women being better at them in their own field - or really successful publicly at all - and this is why women STILL have a hard time breaking into male dominated spaces. We are systemically kept out because men die inside when they feel inferior to women. They were told this wasn't supposed to happen!!!! In fact, the person who spiritually abused me was a man - I see now how he "kept" me as a pet because of my high standing in the community. But this meant I was still firmly below him in certain ways - a much more comfortable place for me to be, someone who challenged him on his "expertise".
This polarity movement is taking a true spiritual concept and distorting it just to set women back. They don't want you to have an opinion or agency - other than "me want money" and "me want sex". They want you to play on Instagram all day and recruit ladies for them to sexually assault at your joint "retreats". They want you to only feel valued if you're made up and dressed up and "desired" by men. None of this internalized self worth stuff, only external male validation is allowed. Ladies, if any of you reading this are with some sort of this type of man, please, I beg you, choose the bear. This is the type of man who leaves you as soon as your body culminates too many signs of being aged. They are entitlted to a specific cartoon image of what they think a "woman" is, and sadly this culture has made young women INCREDIBLY easy to manipulate, so finding another partner is often quite easy for older men. It's all by design.
Here's another spiritual truth that is often obscured: One of the polarities of divinity is the left hand path and the right hand path. The left hand path is the path of control, wealth, using others, egocentrism, etc. The right hand path is about acceptance, generosity, helping others, and sacrifice. The middle path is a path with little to no power - it's the path of comfort, the path most people are on.
When one walks the middle path - i.e. has not really begun to truly develop their spiritual side - they do not yet have spiritual discernment. What happens when they come across someone who has been using spiritual principles to "build their wealth/power" is that they see someone with a spiritual light - and this isn't super common on social media. When we're hungry for it, we're like a moth to the flame. That's why they always know they'll be another mark. The problem then is when we don't have discernment, we cannot tell which "hand" the light is coming from, and often it's very easy to confuse the left hand for the right and vice versa. For instance, I am giving up a large part of my day to write this purely to help others in this community - Carly or MAL or someone might stumble upon this and see it as "evil". But that's because they see the light, but to them it's against their light, so I'm the evil one. But all I'm trying to offer is freedom of mind, and they're mad because they want your bag, and this is dependent on you being confused and them keeping a crumb of clarity behind a paywall. 💰
Now, some of these girlies are walking the "left hand path" a lot better than the others. I dont know many coaches beyond those talked about here, but I would say someone like MAL has a pretty firm grasp on who she is - a scam artist, a liar, and a user. She's always making up stories and whatnot - she's a pathological liar. She will do anything to get her way. This is pretty serious when you've been behaving this way for years and years. Her image is very rigid and polished, and despite showing up unprepared and offering word salad to her paying persons, her "outer circle" (social media feed etc) is much more curated than most of the other coaches I've seen. She's at the top of the pyramid so she has a huge amount of control and influence. If she cracks someday, we'll see it, and usually people struggle to return to the top once they falter. I'm sure she's already showing some signs of paranoia, which is the first sign a high control person is starting to become unhinged.
Then there are the messier girlies, like Carly, and Karen who has recently been more thoroughly exposed here. These ladies show up very vulnerable to social media, and often are struggling with illness - as someone has said here before, Carly's early coaching gigs were about health and dealing with chronic illness, until she realized that space wasn't sexy or profitable. I'm not saying this is the root of all illness, but transient illness can be a sign of a spiritual mismatch in intentions/action - especially with these people who claim to be "healers" or adjacent to that space. You have to walk your talk, or your body begins to show your hypocrisy. There is a part of these ladies who feel they are truly "helping the planet" and get confused internally when the reaction of their "offers" isn't for people to fall down at their feet worshipping them. This is why they say stuff like "wealth is a mindset!" and other magical thinking - most of them have lived privileged lives and have never been "out" of abundance. They think their "luck" is a carefully curated vibration that they can rub off on others. And like, while I believe that being in the vibrations of someone who is more spiritually mature can help "elevate" someone - these people are playing with spiritual practices and, while seeing some results, truly have no clue what they are talking about and dealing with. People who truly understand manifestation, whether left or right hand, are not busting their ass all day on Instagram trying to recruit lukewarm clients for peanuts. Carly tries SO HARD to sell that all of her work is "easy" and she can "take a walk in the middle of the day!" and not work while she's bleeding and whatnot. But girl, you're hustling and thirsty all over Insta all day every day - this is not abundance, this is not wealth and gratitude, it's giving "big empty black hole in my soul that will never be filled except with more money" energy, babe.
Then there are the girlies like xogingy and The Content Queen whose whole brand seems to be just being a mess all over the place. This sells because it makes people think "well I'm messy maybe I can be messy and rich/successful" but the mess for these girls is much more embraced and embodied than with the prim types like Carly and Karen, who want to be pure luxe and sexy and divine feminine perfection. But the luxe and sexy types are really doing the recruiting for their sexual in-person retreats (or clothing optional zooms) because they're just mega horny all the time (which - btw - is another sign of spiritual imbalance)
And that's the thing - being horny all of the time means your energy body is JACKED. It's not a sign of a free flow of creative energy to crave sex all of the time. Of course a major aspect of this is the sexual magic - yes, there is magic in sex, and I think it's where these folks get most of their magic, because they follow left hand sexual magic practice exclusively (control BDSM). They do play rapes (and borderline real rapes and, in some cases, actual real rapes on their clients/partners), orgasm denial, humiliation, pain rituals - all stuff that truly, objectively, isn't good for the soul. And notice how it's almost always one sided - the male being in total control of the female - though, Carly's substack did have a story about how they did a "role reversal" where she raped/humiliated him and that was um, something I read. 😳 But generally it's the women's job to always be turned on and "dripping wet" and whatnot, so that when her masculine partner gets a boner she's ready for him to slide it in. And then that's always the best sex, the sex that you "surrender" to.... On the contrary, sex between "right hand" practitioners tends to leave both partners feeling quite satisfied and sated - heck, even if only one happens to orgasm! Whereas control oriented sex often has orgasm denial which intentionally leaves the person craving more.
All this is to say, no one should feel guilty for being duped, or conned, or confused, even still. Almost all of these people have weaponized spiritual concepts in some ways and are wielding them with the intention to separate you from your money. They actually do have something that works. But they will NEVER sell you the whole story. And the fact is, this experience likely did happen to you because your soul was aching for some sort of uplevel - or initiation. It's just that initiation rarely looks like getting what we want. MAL et al makes it look like initiation is giving a rich lady 5 figures, popping a bottle of champagne, and roleplaying as that rich lady to which you just gave all that money (or at least, roleplaying as her social media feed). But if you're truly in it for the soul, your experience is going to help you uncover your soul. And part of uncovering our souls at this point in time seems to be having some serious spiritual trauma. And I know some people here probably only did this as "playing around" and not serious and unfortunately, playing with spirituality can be can be dangerous in and of itself. These is not to victim blame at all. It just is the nature of the spiritual path that it may growl and bite at you to test your growth. It's not just a sexy pleasure party 24/7, unless you want to step on a LOT of people to get there.
Anyway, this is very long and I'm not sure it's going to even fit into a reddit post at this point. But I just wanted to share some of the spiritual insights I've had over the years (been on my spiritual journey for over a decade at this point). I don't know it all, but I do know that I live with a general peace of mind that I wish I could sell in a coaching package or voxer group. But I can't/won't do that. So I'll keep to my lifelong duty of making longwinded, mega autistic posts on internet forums that might help a few people orient to a less painful or confused frame of mind, free of charge.
But on that note, before I finish, I'll offer my general spiritual advice: Firstly, take a short time every day to do some sort of sitting/meditation. Learning how to quiet the mind is a skill, and it's the first skill required to learn discernment. Once we can quiet the mind, we can start to learn which thoughts are our own and which thoughts we have absorbed from others - and if you haven't begun this process yet, you may be surprised to find out that the vast majority of your thoughts are actually just society, family, teachers, social media, advertising, etc etc, repeating in your mind and taking up valuable real estate. This is the real hurdle to "manifestation" - clearing away all the false desires that get in the way of our true desires. Subsequently, learning about chakras and tuning into my energy body has also given me a good base for insight and clarity that comes from within my own body.
Secondly, just try to think of others before yourself more often than not. Don't justify manipulating people for your own benefit. Oneness means you treat others how you want to be treated - in a gentle, and nurturing way. When we harm others, especially from a spiritual place, we perpetuate harm, and therefore accept that potential harmful treatment of ourselves. Treating others sincerely with reverence and respect, and setting boundaries so that we don't allow people to treat us with disrespect, is how we generate a reality that treats us with reverence and respect by default. A lot easier said than done, but it is possible.
Love and light to you all.

~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD¹
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.^1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.^6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.

Context:The Ushmengar are a Chaos warband dedicated to Vashtorr. They were initially part of the Astral Claws, but when Huron was defeated during the Badab War, they decided to forge their own path instead of following him to the Maelstrom. These Space Marines in particular were some of the first Astral Claws that the Executioners slaughtered during the Badab War, and the Warband was formed by the survivors of their rampage.
In this short story, the Executioners, having just finished a Penitent Crusade, were hunting for the Ushmengar. They had managed to pinpoint them to a Mechanicum forgeworld, and the Death Speaker of the chapter, an Astartes named Razel, a Librarian named Igikura, and a group of Bladeguard descended onto the planet. When they found the Chaos lord of the Ushmengar, named Kagal, this is what happened

The Chaos Space Marine cocked its head to one side, eyes boring into Razel’s. When the Death Speaker was within reach, it nodded and spread its arms wide. The Executioner swung his crozius. The fractal form of the Heretic Astartes shivered as Sharur connected with it. There was the roar of a vast furnace underscored by the shriek of overtaxed bellows, the clanking of gears and the hammering of pistons, and the Ushmengar vanished like smoke blown in the wind, leaving only a chorus of trailing screams.

After this, Razel and his men continued to go deeper into the Manufactorium and ended up fighting a bunch of other Ushmengar

The Death Speaker swung his crozius, but the Chaos Space Marine dodged the attack. The strike went wide, cracking the side of the furnace. Razel punched out with his pistol and sent his opponent’s bolter flying off. Undeterred, the Ushmengar ripped off a piston hammer from a slain ogryn and arrested Razel’s downward swing. Muscles strained, his sinew coils contracted and he drove the Heretic Astartes onto one knee. The Ushmengar’s composure broke and he roared at the Death Speaker. With a burst of vigour he regained his footing and shook Razel off. Burst fire from the Executioner’s pistol stitched an arc across his helmet, which cracked, exposing his metallic face beneath. The delineation between the organic and inorganic had become blurred to the extent that they had become one and the same. Oil bled from ruined armour and unclean flesh-metal.
A storm had broken out at the end of the hall. Lightning flashed, lancing out from furnace to furnace as a rain of brimstone fell. An unholy radiance pulsed in the penumbral gloom, accompanied by the skirling of bronze horns lining the altar. The light rose out of the chancel of the command fane and drifted towards the Death Speaker and the Epistolary, who had advanced ahead to the binary-etched plaza. Within the pulsing storm was Kalag.
Molten metal was siphoned off the blast furnaces, forming fiery wheels into an armillary sphere spinning around the floating Ushmengar. The skitarii shrieked in binharic as they were lifted from the raised walkways, torn towards the eye of the churning storm. They were disassembled, their flesh withering into ash whilst their bionics melded into the spinning rings upon which bleeding eyes had formed. As Kalag moved towards Razel and Igikura, a forge-vault vast beyond imagining spread out behind him, the hellish vision overlapping the reality of the manufactorum. There was the roar of colossal furnaces, the heave and gasp of monumental bellows, and the clang of countless hammers, thudding pistons and clanking gears, underpinned by the screaming of tortured souls fuelling the forges.
Whereas Kalag’s form had been ephemeral before, a charcoal sketch jumping in and out of focus, now it was wholly corporeal. His armour was burned black, running with unclean oils and unguents. Mechadendrites writhed from between the plates like fungal growths, straining for some dire unity with the emergent daemonic mechanism. Around him were the rings of the armillary sphere, which were both armour and a mechanism to unravel reality, spinning faster until they were a blur as the warpsmith approached them
Up ahead, Igikura stood alone, defiant. The crystalline matrix of his axe blazed, focusing his power before it lanced upwards into Kalag. For a moment, the spinning rings slowed and fire raged down upon the Epistolary, enveloping the Executioner. The apotropaic sigils upon his armour shone migraine-bright as they earthed the worst effects of the warpsmith’s attack. The Librarian’s mind was in the throes of a fever dream, the backwash of the Ushmengar’s barrage bruising his soul.
Sensing his brother’s agony, Razel rose and swung, striking again. A resonant peal shivered through the armillary sphere to no discernible effect.
Kalag, whose attention had been thoroughly upon Igikura, glanced at him, his quasar-like gaze boring into Razel’s own. A high-pitched screech preceded the obliteration of Razel’s helm display. His armour felt heavier. The fibre-bundle muscles tensed and servos halted, keeping him upright. Straining, he raised his hands and took off his helmet. When he beheld the ashes of penitence streaking down Razel’s defiant face, the warpsmith sneered. ‘Lapdog of the False Emperor.’ His voice thundered like the hammer of a god striking an anvil
Razel bared his teeth in response, glistening with blood. ‘You were supposed to die at Badab.’ ‘Oh but you see, I did die. We were marooned in the immaterium after our warp drives failed. Bereft, betrayed by a rotting Imperium and an unkind god bedecked in fool’s gold. Where was Lufgt Huron then? His promises and his lies? We no longer need him, nor your carrion god. We have a new divinity to serve!’ Kalag turned towards the growing portal behind him, his arms encompassing the hellish scene and the towering daemonic figure with scythe-like wings who was looking down at the Executioners with an amused interest. ‘Behold the Arkifane! Our salvation! We will deliver this forge-temple of Mars to him!’
"Brother…" Igikura’s voice was straining with titanic effort. "I will not make it to the end." The Death Speaker growled. The Librarian forestalled him. "Spare me your protestations. I will distract him and hold the rings, but I am not strong enough to make the final blow. That falls to you. May your own Penitent Crusade be over after this."
Igikura’s mind soared in the warp like the rising sun. He burned with immaterial energies. Coruscating lightning cascaded down his limbs and flared off him in streamer arcs, with a branching spark earthing itself in the Death Speaker’s crozius. One last parting gift from brother to brother.
Razel wasted no time. With the warpsmith’s attention upon the Epistolary, his armour was free. He trudged forward, pausing only to pick up Igikura’s axe whilst hefting his crozius. Breaking into a run, he leapt upon one of the stilled rings. Razel hurled the force axe. It spun, blazing, still saturated with Igikura’s psychic might and sacrifice. The blade wedged fast into Kalag’s breastplate, tendrils of darkness slithering out of the wound. A few moments later, Razel was upon him with Sharur, imbued with a shred of the Epistolary’s empyric strength. The warpsmith raged, blocking the Death Speaker’s strike with a cog-toothed, daemonic axe. Mechadendrites speared through Razel’s armour, biting deep into his flesh. Gurgling blood, the Executioner drew the mace back and slammed it forwards, again and again, shattering his foe’s armour in a frenzy until his corrupt essence could no longer be contained. The unravelling of Kalag was like that of a collapsing star. The death throes screamed out from his unwinding body, black flame rising between the plates, his flesh unmade into ash.

I can't for the life of me remember what the overall show is about, or this would be so much easier. I think it came out sometime around 2010-2020 but COULD be earlier by a few years, definitely not later than 2020, and definitely not earlier than 2005.
I remember one scene that stands out a lot to me, involving this money obsessed exorcist lady, who is of highschool age or so, lending the male protagonist, also highschool aged, this talisman with a spirit in it, that she says will kill anyone guaranteed if he uses it on them. In the same episode the protagonist uses it on this person he really hates, but it has no apparent effect. The lady talks to the protagonist about the talisman later, and says she would usually charge millions of yen for something like it, and says she wants it back if he didn't use it, before he revealed he did.
I believe both characters are part of some kind of group together, although they don't usually work directly with eachother. I think there was something said about the exorcist lady usually being absent from gatherings as she runs around selling exorcism services, many of which are scams.