How long does it take to get money from accutane

Microdosing: sub-threshold dosing of psychedelic drugs for self-improvement, therapy or well-being

2013.10.16 19:48 ruseweek Microdosing: sub-threshold dosing of psychedelic drugs for self-improvement, therapy or well-being

This is a community for discussion pertaining to microdosing research, experiments, regimens and experiences. The most probable candidates for microdosing are psychedelics, but we encourage dialogue on the effects of any drugs at sub-threshold dosage. No sourcing of drugs allowed! Please have a look at the microdosing Sidebar ⬇️.
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2018.10.29 07:23 siouxsie_siouxv2 Hol'Up, wait a minute!

A subreddit for things that make you go "Hol Up... wait a minute."
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2016.04.01 20:31 Art Progress Pics

Post pics of how your art used to look and how it looks now.
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2024.05.19 03:14 Global_Regular152 When will we get a medieval total war remake?

Mtw2 has been on of the most respected,bought,modded and loved game ever in the franchise. The game has been out for 18 years and still has a community. But yet we’re not getting a remake any time soon. I’m getting tired of the original at this point. The game get repetitive so easily since the ai does a selective of choices when leads to the same thing. I have thousands of hours on this game. Well if we were going to get a remake here’s the things I would want
  1. More cites. So you know how in the expansion pack there’s more cites then in the grand campaign? Like the holy lands are way more specific. And especially in the America’s. I would want that all in the grand campaign. Like Britain for example in the grand campaign it takes me less then 10 turns to conquer the British isles but in the expansion it’s so much harder. Speaking of the expansion pack we should also add culture with religion. It makes sense to have both
  2. More factions. There so much potential in the map like in Iberia of course there’s Spain and Portugal why not add Aragon? They’re right there with the same exact land in history but no there just “rebels” which makes no sense. Same with Norway they have Oslo but no there just rebels. Same with Sweden they have Stockholm but no they’re just rebels. Same with Finland they have Helsinki but no they’re just rebels. Same with Ireland they have Dublin but no they’re just rebels. Same with wales they have Inverness but no they’re just rebels same with Estonia and Lithuania I could go on for a long time but I’m going to stop there. The map feels dead at some points
  3. Bigger map. Kind of the same with number 1 but we should expand more like Iceland would be fun same with the folk islands. Especially expanding Norway,Sweden and finland more instead of them have little pieces of land. But not to big like empire or something I want there to be a lot of cites in a good size map like. I want the map to be like europe(of course with North Africa and the Middle East)
  4. The ability to make a branch out of your fraction that would be managed by the AI kind of like a vassal. You know what I mean? Like it’s so annoying going on the crusade then losing the settlement 5 turns later. Instead of that you could make a branch like the Holy State of England(made up name) where you give up that land and the surrounding cities to make a new faction which would be loyal to you and pay you tributes. You could make your 2nd son the head of the faction. Notability the faction would be controlled by a AI and after it’s made you can’t unmake it or change the faction leader. Also since we’re talking about sons they should add the ability to change your faction heir it’s present on the mobile but not on PC.
  5. Events. So again you know how in the expansion pack there’s events like Willam Wallace showing up? I would want that like key points in history like the Turks getting the grand canon or the French Revolution where there’s new faction that tries to take your faction kind of like the baron alliance? That would be interesting and challenging this would probably only in hard mode
  6. Trading and prisoners . Once you establish trade rights,map information and military rights it’s dead after that. Besides settlements. So instead of having 3 options release,ransom,execute we should add capture where you would keep the prisoners(Along with generals and family members)within your army which would slow you down and later transfer them into settlements where you could bargain them in diplomatic missions. this would also add more building options.Notably this would lower your security and lower public happiness.
  7. Also better graphics obviously. But I don’t want change to the gameplay mechanics they’re already pretty good.
That’s all I would want. What else would you guys want from a remake?
submitted by Global_Regular152 to Medieval2TotalWar [link] [comments]


2024.05.19 03:12 Nathanax Advice on what I (21M) can do better with (19f) gf?

Girlfriend and I have been together for 8 months now I adore and love her to death and would be willing to do just about anything for her and her family + friends. Sadly the last five months of my life I’ve encountered hardships completely out of my control and have gotten knocked down over and over again. From losing two jobs cause of two car engines blowing up on me, parents divorcing and even to my cousin taking his own life. Recently I’ve been stuck with my gf for the last month or so tryna find a job close to my house I can walk to till I can pull out a loan for a vehicle. Now I’m in a place where even I find it hard to connect with my gf. I try so hard even through these financial struggles to put her first or still take her out for dinner and clean around her apartment and mine as well even tho the mess is normally coming from her and leave her notes and have tried showing valiant effort in even helping her friends and family when they are around with things. My girlfriend has always been a person to where she can never really find interest in things she’s never had a hobby or anything interest her now that I think about even the thought of me trying to show her something new makes her upset and leads to a fit, most recently Parts unknown by Anthony Bourdain which I thought she’d enjoy for her love of food and travel and sadly now even conversation with me seems like a task that she can not do without looking down at her phone and going on tik tok or instantly mentally checking out on the nearest speckle on dust on the wall. It’s made me want a lot of space and alone time recently which I’m all honesty I feel bad for feeling this way especially when she asks me “do you like me still?” After I got somewhat annoyed at her refusal to put our phones down and finish our conversation we were having. Granted I understand the importance of alone time and for her as well I know she can feel the same so I’ve offered many times to give her space for the day and she refuses to let me to and almost gets upset. I feel severely neglected and I barely feel like I’m dating my girlfriend anymore and it’s starting to exhaust me. I’ve brought up similar talking points as this before which have led to her looking at me like I’m stupid for feeling any bit of neglect and also brought up how she is overly rude over little things such as throwing a fit over her sister wanting to eat at a restaurant my gf has never been to before for her graduation dinner and when I call her out since the beginning of the relationship she has always gotten angry and upset and tells me how I’m wrong and I’m starting to feel like it’s all my fault when at times I know it objectively isn’t and I’ve worked hard on the old cliche of happy wife happy life which is starting to exhaust me and I truly feel confused and wrong for wanting space and wanting change from her for so long now with her not making any sort of effort. I understand neither of us are emotionally mature as we will be one day but with her I feel exhausted begging for some form of intimacy from conversation or even cooking and dancing to some music. I was brought to tears over thinking about how happy she once was even just walking around Costco with me as corny as that sounds and now I’m somewhat lost because I feel like I can’t have a mature and healthy conversation about our feelings together without her shutting down emotionally.
submitted by Nathanax to relationship_advice [link] [comments]


2024.05.19 03:07 tragicrebel After 15 years, I’m auctioning off my beautiful, freakishly inexpensive $1,250/mo 2BR rental cottage in Clarksville/Old West Austin.

I came to Austin for college and got grandfathered into a gorgeous, insanely cheap rental in one of the loveliest, and most expensive neighborhoods in Austin. After two decades, my rent has only gone up a couple hundred bucks.
If you’re familiar with the West Lynn/Jeffrey’s/Fresh Plus/Josephine House area you know it’s essentially within walking distance to so many awesome parts of Austin there’s too much to name! About as close to downtown as you can get and still be surrounded by trees. My freestanding home is a little funky slice of Austin history, 140 years old, hardwood floors and stained cement, two stories, two bedrooms, washer and dryer connection, gas stove, bathtub & shower, 1Gbs WiFi from AT&T (if you have an account), kitchen & dining nook, living room, French doors, 1200sq ft, lots of natural light, stained glass windows, a stone patio with picnic table, central heating/AC, upgraded see through glass kitchen cabinetry, garbage disposal, set off the street so you’re surrounded by greenery, with a private parking space and much more. Pet friendly and renovation friendly.
I’m raising money to return to my home country on the other side of the world, so I’m auctioning off my place for a finder’s fee. I’ll make sure you take over the lease, security deposit is covered, and you can even have my fridge, washer & dryer if you want! Move in anytime after 6/15.
Happy to answer questions, although I’m only going to share pictures and certain details with folks who make serious offers. If you’re interested in making such an offer, take a minute to consider how much money you would save over the course of a single year (or as many years as you want) living in one of the coolest hoods in town, in a house that will make all your friends jealous. Then DM me a bid based on what that would be worth to you.
submitted by tragicrebel to Austin [link] [comments]


2024.05.19 03:06 House_of_Lij Lij's Drag Race Recasted: CVSTW EP4 "Comedy Queens" Lip-Sync

The "Comedy Quens" Stand-Up Challenge results are in!
DURING THE EPISODE...
Monét X Change has won the "Cameo-Style Filmed Videos" Mini Challenge!

── ࣪˖ ࣪ ⊹ ࣪ ˖ 🇨🇦 ࣪˖ ࣪ ⊹ ࣪ ˖──

ON THE MAINSTAGE...
The tops and bottoms of the week step forward to hear their critiques...
Adore Delano receives negative critiques from the judges. Brad told her that the main problem with her performance this week was that she started well and did well overall, but she let them see she was sweating too much. She kept dropping the f-bomb every 5 seconds and dropped her cards when she knew they were out of order. She didn't let it flow as much as needed. She was allowed structure like every other queen, but she relied on the structure instead of being her naturally funny self. Her runway this week, though, is gorgeous. She blended her rebel aesthetic into this gorgeous elevated punk look.
Angeria Paris VanMichaels receives positive critiques from the judges. Brooke told Angeria that her performance this week was just a fantastic level. She came out and told them the funniest story on the planet, and even though they didn't believe it was 100% true in hindsight, the way she said it had them hooked every second. Facial expressions, voices, body movements; she put everything into that performance to make them laugh, and it worked. This week, her runway also disappointed them; loving how she made this southern belle mixed with this plaid aesthetic but noticed minor clashes.
Eva Le Queen receives positive critiques from the judges. The judges say that she's one of those queens who don't know what she'll do next because this comedic performance was fantastic. She blended stories from her childhood into this funny stand-up set, even working with the crowd to make them laugh and make herself relatable. That's what she did best as a comedienne, making herself relatable to the crowd and making sure they felt comfortable laughing at every joke she made, no matter how wild. Her runway was gorgeous and different for her, but just because it's plaid doesn't mean it's Vivienne Westwood.
Monét X Change receives positive critiques from the judges. Traci says she had the best performance of the entire night. She made an intelligent decision by putting herself last because she warmed them up again with one final excellent performance. She told these fantastic stories, complete with crowd work and whole-body movements where she dove across the stage and made them laugh. She had no holds barred with this challenge because she put her everything, clearly so hungry for a win. Even though her runway this week isn't their favorite, they love how she blended the plaid into this dragged-up lumberjack.
Plastique Tiara receives negative critiques from the judges. The judges say that she is more than just a pretty face; she had to prove that when it came to comedy. It wasn't that she wasn't funny; it was just that she performed it as more of a roast than a stand-up. She came out and started telling them stories about the competition and making fun of the other girls. It was funny at some points but oddly unrelatable for others since she was saying things that would only be funny if the audience had been there. Her runway, though? It was a superb Heathers-inspired ensemble with a funny death reveal.
Shannel receives negative critiques from the judges. Brooke says that the main thing they have to say about Shannel is that she left them more to be desired this week. She had to start the whole thing since she wanted to be first so severely, but she didn't do what was required of her. She is a drag professional by the way she handled the scene. Still, she seemed to be monologuing consistently and needed to make more effort to interject the comedy into a speech. This week's runway also disappoints them since this is her 6th time wearing a gown, and she needs to switch it up.
Angeria Paris VanMichaels, Monét X Change, Condragulations! You are the Top Two All Stars of the week!
Plastique Tiara, Shannel...I'm sorry, my Dears. You are both up for elimination.

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DURING UNTUCKED...

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AFTER DELIBERATION...
Angeria Paris VanMichaels and Plastique Tiara make their lipstick choices and walk back to the stage, where the other Queens are waiting for them...
TOP2: Angeria Paris VanMichaels / Monét X Change
HIGH: Eva Le Queen
LOW: Adore Delano
BTM2: Plastique Tiara / Shannel
The Top Two Queens will Lip-Sync for their Legacy to "Your Daddy Don't Know" by Toronto. This is your chance to impress me, win the challenge prize, and gain the power to give one of the Bottom Queens the chop. Good Luck, and Don't Fuck It Up!
POLL / Track Record
submitted by House_of_Lij to RPDRfantasyseason [link] [comments]


2024.05.19 03:04 HARRY_FOR_KING In Fire and Blood there IS a feminist contender for the iron throne...

...and it is not Rhaenyra.
When Rhaenyra took KL and the question of how to reward her dragonseeds was brought up, the idea of marrying them to the elder daughters of nearby noble houses was brought up as a way to give them lands. Rhaenyra was advised not to do so however, as it would raise questions about the inheritences of younger sons who would suddenly be threatened by elder sisters, potentially causing her to lose allies. When given the chance to "make a new order" which would empower women but potentially diminish her personal power, she chose herself, and ironically lost the support of the dragonseeds.
It is later in F&B when we actually get to see what a feminist queen would look like. Essie and her paramour Sylvenna Sand, ruling through Gaemon Palehair (purportedly a bastard of Aegon II), issued multiple proclamations which would improve the living conditions of women.
I put the last one in bold, because here is the only pretender to the Iron Throne who EVER did what Team Black fans think Rhaenyra is about.
This is a pretty obvious and baseline take from F&B, but the thing I have to add is how the Maesterly account portrays the court of Gaemon Palehair. "Whore" is not just a factual term for the profession of prostitution, it can also be a slur against any and all women who copulate for their own personal reasons and not for the express purpose of pleasing their husband. In Westeros there is a clear connection between the two meanings of the word in the story of Seara Targaryen: for being a woman who had sex with men outside of the rules men created for her, there was only one place for her where she could be accepted: a brothel. Jaehaerys's turned Seara into a whore, it was a self fulfilling prophesy by trying to force her into the mould of a septa that she should escape and try to find the only place where she would be allowed a degree of sexual freedom. The exploits of Seara are not just a chance for George to put women down through the Old King's mouth, but shows us the pipeline directly to prostitution and infamy for any woman unfortunate enough to try and live with the same freedom of men.
We are supposed to recognise the connection between Seara, Essie, and her paramour. The Maesterly account is obsessed with putting down Gaemon's mother and court as a bunch of whores. This may be factually true, but it may be equally true that Essie were a rape victim thrown out of the Red Keep: the point of calling them whores is not to give the reader facts about them, but to denigrate them.
The Maesterly account in F&B, despite the obvious bastardy of her children, does not deign to treat Rhaenyra like this at all. Rhaenyra is portrayed as jealous, irrational, fat, but not treated like a whore. To be denounced by the historians as a whore, you have to do actual feminism.
This is my take on feminism in F&B. I think it is definitely there, but not in the courts of either the Greens or Blacks.
submitted by HARRY_FOR_KING to HOTDGreens [link] [comments]


2024.05.19 03:03 Emergency_Survey_723 Benefits of "Protected Consumers" in WAPDA Bills

In previous post, I mentioned how you can save a significant amount of money by just changing your old fans in your homes with new inverter fans.
In this post, i will discuss how some people can become protected consumers of wapda to get electricity at a cheaper price.
Wapda charges its customers in slabs of 100 units, where crossing each slab limit will increase per unit rate by a lot. Forexample, from 0-100 units, rate will be Rs 16 per unit, but from 100-200, rate will be 23 per unit. Similary for higher slabs it is 27, 32 and 35.
But Wapda has also declared a protective customer category, which means those users whose consumption haven't exceeded 200 units per month for the last 6 months, then from 7 month ownward they will be charged at protective rates which are very low. Forexample, 7 Rs per unit for 1st 100 units and then 10 Rs per unit for next 100 units. These rates will continue as long as he doesn't consume more than 200 units in any of the next months. But once he breaks his streak, he will no longer be protected and will be charged at normal rate and will again have to wait for 6 months to get this perk.
As a practical example, lets have a look at billing of Protective vs Regular customers
🔸Protective customer uses 199 units:
100units x 7 = 700 Rs
99units x 10 = 990 Rs
Cost = 700+990 = 1690 Rs
Total bill = roughly double the above amount for taxes and fpa = 3400 Rs (for 199 units in protective category)
🔸Regular customer uses 199 units:
199 units x 23 = 4,500 Rs
Total bill = roughly double this amount for taxes and fpa= 9,000 Rs ( for 199 units for regular customers)
🟢See the difference, 3400 vs 9000 Rs💰 for same units
🚨But if protected customer exceeds 200 units, for example 201, then regular rate will apply:
201 units x 27= 5,500
Total bill= after roughly doubling it for taxes= 11,000 Rs
So by breaking the streak of 200 units even by 1 unit, protective customer will become regular and will jump from 3,400 to 11,000 Rs. 😲
▶️So here are few tips for those whose bill comes around 300 units and they want to save money by going below 200 units:
✔️By replacing an old fan (which runs most of the time) with inverter fan, you can reduce around 50 units from your bill per fan. So by changing just 2 of these fans , you can easily get down to 200 units from 300 units.✔️Furthermore ,you can remove stabilisers from refrigerators as long as your voltage is stable ( this problem of voltage fluctuations only exists in some rural areas but is rare in cities), because these consume 45-50 watts of power for no reason, which itself adds 32 units to your monthly bill. You can use surge protectors instead for voltage protection.
✔️If these things are already optimized and you are still not below 200 units, then you can opt for small solar setup enough to produce 100 units per month, in which case you will use 200 units from wapda at protected rates and another 100 from solar to meet demands every month.
I hope it helps.
⚠️Note: Users with consumption above 300-350 units might not be able to benefit from this.
submitted by Emergency_Survey_723 to pakistan [link] [comments]


2024.05.19 03:00 teeth_03 As a casual 3 star player, the economy is unsustainable right now

When the event ended, I had around 100k Hunt Dollars, I'm now sitting at 85k and it just keeps dwindling away with each match. This is using cheaper loadouts.
Not sure how long Single Bounty Only will last, but I suspect that not having any of those "sneak in and grab 1 of the 2 bounties and leave" matches is why this is so hard. Having guaranteed PvP makes this almost an entirely different game IMO and the economy doesn't work for it.
If single bounty only is expected to be a long term issue, they might need to make some adjustments to the economy until its fixed.
I think two changes that would go a long way would be to buff Extracting With Bounty payout and buff the money you get from looting, so you get better rewards when you do actually win a game.
Kind of random, but maybe drop the cost of Vulture so you can guarantee the loots to go around as well.
submitted by teeth_03 to HuntShowdown [link] [comments]


2024.05.19 02:55 Former_Band2213 A suicidal jerk

First, for context; I was raised in a household where I would get either physically or mentally beaten if I did something wrong. For example, if I were to talk back to my mother she would mentally hurt me, which is why I have a low ego and constant suicidal thoughts. Now I'm an even worse person who gets mad every time someone comes into my room.
My mom believes that I am an asshole and I do too. I also get mad when anyone touches me without permission, causing me to flinch back and make them either worried or upset. I have lashed out at my own mother for touching me multiple times without permission and she tends to insult me when I do so.
I do have feelings, I'm not some emotionless person who doesn't care about anyone at all, (Not that people who hide their emotions are all like that) but I like to keep my bad emotions hidden since I used to get bullied for being the crybaby. My bad emotions are saved until I'm at home and reading, that's when I let all my bad emotions out. Nobody cares about how I'm doing (if I'm feeling bad), and I enjoy that lack of attention; which is why I like keeping my emotions hidden.
I found a quote that perfectly describes how I am in public: Chin up, Princess, or the crown slips. I'm not sure where it comes from, or who said it, but in my mind I'm always saying to myself Don't show your emotions, or you'll face bullying again. I hate myself for this, but I feel I should get over it.
Anyways, enough backstory, I just accidentally hurt my dog because I was mad, but gave her some treats right after because I felt bad. I feel like an asshole because I feel like I mentally hurt everyone around me. I don't deserve anyone who's nice to me because I just put on a mask so I can keep friends. I'm the definition of a faker and I don't get why I'm still alive if I just hurt everyone around me. I take everyone for granted and if they get mad at me my mask just slips off. The only negative emotion I show in public is anger and even when I do show my anger I just get backlash anyways so I always try to apologise either the next day or in the next 2 hours. Sorry to anyone who's actually taking time out of their day to read this, I know it's long. I've been forgotten by my father, who left when I was born; He doesn't even have partial custody and he forgot that I exist, leading him to forget my birthday last year. I'm basically the opposite of a narcissist, (for anyone reading this who doesn't know what a narcissist is: it's someone who has too high of an ego) meaning I hate everything about me, from my mind to my body to my personality to my life. I have thoughts of death every day and I know most people want long happy lives, but I don't.
I kind of just feel the want to get on a private jet as the pilot and purposely crash the plane.
I do self harm, but not cutting, I'll get into that later. I already have the tools to hurt myself. I sometimes pick at my body while finding everything that people hate about me, even if they don't say it. I honestly am a brat, and my mom is so helpful at cheering me up. Lies. She is awesome at making me feel better about myself. Lies. My dad is always there for me. Lies. My life is absolutely awesome. More lies. I honestly hate everything about me, like I already said. I feel like everyone I love is so happy and has a great life, other than this one friends of mine who is going through the same thing as me. We both seemed to have started getting suicidal thoughts for the same reasons. Our grandparents hate us (In my case grandparent) and they treat us like dog shit as if we're not human. We also started having these thoughts at the beginning of our fourth grade year (In which we were in the same class.) The only two things keeping me alive right now is that I'm a fucking pussy who can't act on her thoughts, and that I have things to research that I wish I had. A recent example was a study of skin cancer. I believe I have a disorder called Body Dysmorphia, meaning I see my body as a very disoriented version of it. People say I'm skinny but when I look in a mirror I see something different. I enjoy starving myself, which is one of the only types of self harm I do; The other type of self harm consists of picking at my skin with any objects that will pinch, basically I would use a crabs claw if I got that desperate to feel pain. Pain brings me joy for some reason. I'm not talented, I'm only skilled. I have nothing special to keep me going and I'm a financial burden on my already struggling mother. Sometimes I just think of killing myself but then I think about why my mom would think. All of her friends either forget about her, abandon her, or die.
I can't talk to my mom about anything, because she's not reliable with emotions. What I can rely on her to do is feed my want for my life to end quickly.
submitted by Former_Band2213 to SuicideWatch [link] [comments]


2024.05.19 02:52 04ayasin 3 Week Review

I've owned my Polestar 2 for 3 weeks now and have a lot to say about the car.
TLDR: - Looks good on the outside and inside with performance and plus packs - Pilot pack adds to an interesting driving experience - Range and electric adds to longer journeys due to charging time and public charging prices are more expensive than petrol
Model Year: 2021 Interior: WeaveTech in Charcoal with Black ash deco - This option is a little dull to be honest. I haven't been in a Nappa Polestar but in pictures that looks really nice. I believe even the slate would look better. - I do like the comfort of the seat but I have had comfier seats. Where it really shines is the number of adjustments you can make to it. - The golden seat belts to match the brake calipers on the performance pack are a nice touch - The centre console is occupies a lot of space without providing much storage. They have tried to give some of that back with the little side storage on it which I like the concept of - no major comments about the controversial cup holder but I wish the centre storage where the second cup holder is had more space - The infotainment system is a little slow and I wish the screen had a button to turn it off for when it's not needed. Overall though I like the Android OS and can see potential once it has time to mature some more. The risk is Google likes to randomly end projects so who knows if it will get canned in some nearby year. - I really like the integration of Google maps. Firstly into the driver HUD and secondly that it can read the battery level and automatically add stops for charging points - The 360 camera is nice but I wish that the view had rear camera in a split screen. Still it's not too bad as I can use the mirrors at the same time to help. - The design of the gear knob is cool, especially with the Polestar logo. - I have the panoramic roof which I think is really cool. Unfortunately as the driver you do not get to enjoy it much. - I wish the lights had more colour options other than white - I like the music auto plays when I sit in the car - I like that there is no on/off. I just sit and drive. - The Harmon sound system is okay but could be clearer. I haven't played around with the mixer yet so maybe need to adjust that for better sound quality.
Exterior: Midnight Performance Pack - Overall I like the exterior of the car. It was one of the main reasons that I bought it. Especially with the performance pack. - Not 100% sure about the front grill though - The front lights look pretty cool. I like the motion they make when you lock/unlock the car. I have the Pixel lights and seeing them in action is awesome. - I think the back looks really nice. I think the rear light looks futuristic and the motion it does when you lock/unlock the car puts the icing on the cake. - The Polestar logo on the car blends in really nicely and isn't so in your face. - The rimless wing mirrors look great. Now whenever I sit in other cars I notice the ugly frame around the wing mirrors. The blind spot warning lights on them are really useful too. - The car has an interesting stance making it somehow look bigger than it really is - The two tone alloys and eye catching yellow brembo brake calipers make a nice combination
Motor: Long range Dual motor - It makes the range a little too short . It has over 50 miles less range than the long range single motor. Despite this I like having the additional performance power available and therefore I am willing to make the sacrifice. - The reduced range and longer recharge time versus a petrol car does add time to roadtrips unfortunately. Charging prices on the road mean the long journeys are more expensive than a petrol car as well. However for local driving it is great and charging at home is very easy and convenient.
Driving experience - The instant acceleration is fun and for this reason I'm seriously considering getting the performance software upgrade. - The steering, even on the firmest setting is still too light for me and doesn't really feel connected to the road. This is to be expected for this kind of car I guess. There is understeer when pushing it a bit as well. Interesting that you can make the car slide. - I am a convert to single pedal driving it is really nice to not really have to use the brakes. I really like going into corners and not having to use the brake to adjust the speed, as well as when having to come to a stop just letting go of the pedal and slowing nicely to a stop. - I'm undecided whether to have creep on or off. I have it on at the moment but I'm considering turning it off - adaptive cruise control with the lane control is amazing on motorways, the car is almost driving itself. Not so useful in local driving, especially in the UK but there's nothing wrong with old fashioned less autonomous driving - I had a fun experience with the rear collision detection. I thought the seatbelts were trying to choke me but after a moment realised that the car is trying to protect me when it thought someone was going to hit me from behind. I love that feature.
Keys: - The fat keys are too big but I barely use them - the active lifestyle key is slim and combined with the touch sensitive door handles suits me very well - I do not believe in my phone enough yet to use it as a full time key however it is very convenient when I just need to go to the car for any quick reason. I don't have to take my key with me because the phone is the key making it a lot more convenient. The polestar app is fairly limited but it's useful to see the battery charge, whether you forgot to lock it and where the car currently is.
One last point that I didn't really know where to fit is that I really like the online documentation that is available for the car, it's really clear and explains a lot of things and I can search through it using Google
Let's see what the next few weeks, months and years brings.
submitted by 04ayasin to Polestar [link] [comments]


2024.05.19 02:51 Late_Supermarket_422 How do you guys go out when EPing?

Really struggling to have a life with pumping. It feels like life is all pumping feeding burping and diapering. I’m currently 14wpp and doing 6ppd. Before baby we were very adventurous and outgoing, spent almost no time at home. Now when we try to go out, we have the following problems due to pump life: - I use the willow go to pump on the go. It hasn’t been working well, it often dies at 15m mark when fully charged, sometimes one side doesn’t extract any milk at all while the other does. All the time, it fails to empty me completely, causing clogs on the day we go out relying on the willow go. What pumps are you all using in the car? - breastmilk storage, it’s one thing to carry some already pumped milk with you but now you also gotta store the milk you just pumped - my partner blames me for having many things keeping us tied up from going out. It seems that I’m the only one who’s worried about her feeds and my pump sessions and it becomes my fault when we’re struggling with any baby related thing when being outdoors. Apart from this he’s been fantastic dad at home but just fails to understand how hard pumping is when I go out - warming up baby’s milk when outside - positioning baby to feed in the car / outside without pillow and my home feeding setup - willow go is a pain to pour milk from after pumping and often spills in our brand new car - baby does not cooperate with feeding when outside - the shenanigans to leave the house are an entire mission: get myself ready, get baby changed and ready, warm up milk, feed her and pump (preferably simultaneously with help from husband), burp then put her to sleep and then strap her into the car seat, pack her milk to take and pumps to take with me, finally get out the door. What’s your leaving routine?
These are just some of the frustrations that are causing us burnout when we go outside, but when we don’t, we’re feeling too restricted by pumping. Please share your pro tips on how you manage to have a life with pumping
submitted by Late_Supermarket_422 to ExclusivelyPumping [link] [comments]


2024.05.19 02:50 No_Track3680 First post

Hello to whoever sees this, it is the first time I make a post here, I just want to say that the purpose of this post is just to express myself, how I feel, feel free to leave your comment, it doesn't matter if it's mockery, hate, support everything is welcome. I am 20 years old, and 8 months ago I was diagnosed with an anxious-depressive disorder and I am currently dealing with it. I have never seen the need to go to a psychologist. I only visited him once when I was little and I never did it again until 9 years ago. months, I visited a psychologist and after several appointments, he diagnosed me with this, and honestly it took me by surprise and in the following months everything has been worse, Like any family with old habits, they do not believe in these types of issues, it is horrible to know that your family does not support you and sees it as nonsense, I have friends, but my circle is reduced to 3 friends, yes, my inner circle is only 3 friends, all my life I was raised with women, my father abandoned my mother and me when I was 6 years old, and he was in prison for a crime in which he was accused but that is a story for another day, the point is that I grew up with my grandmother and my grandfather, my mother was an absent mother and was never at home, she never shared time with me and my family made me hate my childhood, my aunts were the main ones along with their children, they despised me every chance they could, Because I don't have the same things as your children, I'll be honest with you, I don't remember almost anything about the supposed things that I had, but honestly I was one of those who never took money to school, the one who wore things that were of no use to others. and you know, from the age of 9 I began to change my perspective on the world, I had learning problems but after I was expelled for not having attended a mathematics exam due to getting sick and going to another school, I understood that I had to change everything and I matured. an apparently quick way, as a teenager I went through what normally happens, falling in love, having a girlfriend, etc., I won't say so many details so as not to get away from the main thing, but turning 15 my perspective on life changed again, I understood that love is not They are just nice words, good compliments, I had a relationship with a girl older than me, she was 17 and I was 15, I guess it's strange but depending on the colors haha, well in the end I was fooled by someone who had similarities to a character in a book, So you can see the reason was extremely stupid, that to this day I have the belief that age does not define your maturity, in short this affected me a lot and being the boom of 2020, it was worse, I fell ill with that, you already know My mother almost died, but thank God she is alive, well, I left high school and went to university, and then I moved on to what I am currently living, In September 2023 I was detected with profound depressive anxious syndrome. At first I thought it was a joke but when I investigated, the truth is my world changed for the third time. At that time I had a friend named Carmen. We will call her Carmen. Carmen has or had, I don't really know. I fought with her, because she left me to go to C0g3r, the truth is today I don't think it was a stupid reason to fight, I just wanted her to help me because of the situation I was in, I was very sad and I didn't I had someone to talk to, I told her and she left me like garbage waiting for her at my house to be able to talk to her, and honestly this changed my perspective on the ties with my friends, especially with my female friends, the Most of my female friends tend to say that all men are the same and that's typical. I'll be honest, we all sin equally, both men and women. I'll tell you something. I'm usually someone who's quite reserved with people. I don't talk much. I'm someone who's quite introverted. and I think I manage to create bonds with women easily, so I grew up with my grandmother, my older sister, and with an aunt on my mother's side, and I saw the mistreatment they do to her, but well, I got off the topic, he Anyway, I got into a fight with Carmen, and we haven't spoken in a while. She doesn't know it but the reason I called her was because I wanted to take my life, I think I didn't do it because I wasn't determined enough, I already had where and with what but I decided to ask for help but they denied it, that's why since I was little I did my things alone and the things that were difficult for me to do I did as best I could and if it turned out badly I learned from it and did it better the next time. I am currently on medication but I don't know what to do anymore, my friends give me recommendations about everything, and my psychiatrist and my psychologist help me with certain therapies, I have tried to change several habits to feel better but nothing works for me anymore, I wanted to resume my physical activity going to boxing, but since this is the penultimate year of my degree, which is an engineering that in itself is quite demanding of time and a mental effort due to many sleepless nights, I am on the verge of being admitted to a psychiatric hospital
submitted by No_Track3680 to u/No_Track3680 [link] [comments]


2024.05.19 02:49 Witchy888 Family triggers me even more than my FP does since I've gotten medicated.

TW, I do talk about my abuse and trauma in this, mostly about verbal and medical neglect.
It's almost like my family knows what they're doing to me. It's honestly frustrating. I'm almost always the one being neglected or ignored in conversations or at family events. And yeah, they were the ones that basically caused this damn disorder, it makes sense! But they apparently don't even know why I want to move into the college dorms so badly this fall???? How do they not see that I'm actively trying to not be around them specifically for extended periods of time???
I've always been the one my family put down and at this point I never know if I'm splitting on them or if the anger, abandoned, frustration, and stress I feel about/from them is actually rational. Because of that, it's honestly made me so confused with my own splits on my FP(who also has bpd). I feel like I'm going fucking insane at this point.
My family has always triggered me, but ever since starting medication back in February, I've noticed that they trigger me even more than before. I'm not as triggered with my FP, which is honestly a great thing! I haven't had any huge, explosive splits on them since starting my meds. But my family though? I fucking hate them. The parents that I live with have no regard for my food sensitivities(both in terms of the few allergies I have and also for sensory reasons(I'm also autistic btw)) and taste. And my mom(I don't live with her) thinks its a great idea to have 13(now 12) animals in her small-ass duplex and lets her new great dane "puppy" piss and shit everywhere and terrorize(not play) the cats. I literally had to grab my cat from there and now one of my friends are looking over her for a few months. Thank god.
My parents always hound on me for not having a job since August of last year, despite the fact that I've been applying for and interviewing for jobs actively since then! It's literally not my fault that the only "job" I have right now is Door Dash, which makes me constantly spend more money on gas than I can actually save up. Not to mention, it burnt me out pretty quickly after doing it for two months! They always try to "help" by sending me job listings, 99% of them I've either applied to or literally won't be able to do physically due to also being physically disabled! Which brings me to my next thing!
They have absolutely no fucking regard for my physical and mental health at fucking all. They simply think I just have depression and anxiety and thats it. They don't want to even believe that I'm autistic and have ADHD, BPD(which I basically refuse to tell them about, but I'm tempted so they learn how it's caused so they see just how much they fucked me up), DID, and maybe even Schizoaffective Disorder, which I'm still trying to work out with my therapist if that's another thing wrong with me or not. My parents don't want to even believe that I have POTs or dysautonomia of any kind, hypermobility, Ehlers Danlos Syndrome, etc. They don't even believe me when I'm telling them that my vision is getting fucked because it's getting worse way too rapidly for someone my age(21) when there's literally a whole family history of this shit on my mom's side! Not to mention, we know jack shit about my grandmother's physical and mental health related shit on my fraternal side except for that she died of cancer in 2006! My parents refused to do any medical shit for me as a kid and still do now. All they would do was take me to my yearly checkup, the dentist once a year(when you're supposed to go like 2 times a year) and the eye doctor once a year. They don't take me seriously at all. When I was 11, I literally almost died from the fucking flu because of them! They made me stay at home while they went to my sister's band concert. Meanwhile, I couldn't fucking breathe and started choking on my own damn mucus for multiple minutes straight. I was fucking terrified. Now I'm always scared whenever I get sick, even if it isn't as serious as what I had went through. There's a reason why I'm not going to be seeing the family optometrist after my most recent appointment. Every medical or mental health professional that my parents would make me go to would gaslight me or brush me off.
Their negligence still holds up today too! And thats what fucking pisses me off! They helped my siblings pay for things for college but refuse to help me because "I didn't do well in high school, so it wouldn't really be a good idea to spend money on you because we know you're not going to do well in classes." What the fuck???? Maybe the reason why I didn't do well in school before is because y'all didn't LET me have any accommodations, refused to get me tested for literally anything, always put me down, and fucking verbally abused and neglected me 24/7! Just a month ago, I got into an argument with my stepmom and she legit told me, "Well, you don't have a job and I just want you to have a purpose in life." Why would you say that to someone?! Let alone your own kid?!
Oh don't get me fucking started on the younger of my two stepsisters(the older one hasn't done shit to me. She's the only one I'm not triggered by.) and how she has lied about me to my parents, aided/aids in my abuse, etc. She basically gets all the love and attention from my parents. They encourage her to do things, to live her best life, etc.
I don't even know if what I'm feeling right now is me splitting on my family or justifiable anger. All I know is that I'm upset with them and that I don't want to live in this damned house anymore. I've been wanting to leave it for years now but was always held back from it for one reason or another. I'm fucking upset.
submitted by Witchy888 to BPD [link] [comments]


2024.05.19 02:48 OutdoorsLifer2024 I'm in my mid-30s, I really thought I wouldn't have to deal with friend drama anymore

I just had a "falling out" with two of my [previously] closest friends of 10+ years and I'm not sure what happened. This isn't a lack of awareness thing or theres-a-lot-more-to-the-story-but-I-just-want validation-regardless-of-the-facts thing. Here are the facts:
It really hurts to realize that I had people at this point in my life - after loads of personal work and proactive communication on my part - that would be so conflict-avoidant and choose passive aggression over a conversation. I feel like they "cancelled" me for doing something awful that I have no recollection of - have I been stabbing people in my sleep!? Because their behavior and treatment of me is making it seem like I did. I was reading a PsychologyToday article about how active avoidance is a form of silent bullying, and it definitely felt that way. Not that I think it was overtly malicious, but the effects (pain of disconnection, feelings of isolation) are the same.
My therapist believes that they are threatened by my success personally/professionally and used any excuse to create distance. In that case, the level of immaturity is mindboggling to me. I am happy for people who I care about when good things happen to them.
Can anyone relate? I'd appreciate a reality check because this situation made me question my reality.
submitted by OutdoorsLifer2024 to AskWomenOver30 [link] [comments]


2024.05.19 02:46 Odd-Dragonfly-6607 How do I deal with irresponsible 21yo?

My 21 years old daughter lately is acting really childish and rebellious and I need some advice. Im a single parent. My son (19) is really mature and knows all the things I’ve been through for them to have an easy life, so he respects me and always tries to make me happy, he even takes me out with him so I don’t stay at home alone. My daughter on the other side has always been childish, I have to admit I’ve always treated them differently, I’ve shown her love and affection, and I’ve treated her like a princess while my son always had to solve problems by himself since he was a kid, he had to take care of his sister when I wasn’t around and he suffered a lot because of the pressure I’ve put on his shoulders. Lately my daughter started dating this guy and I happy for her obviously. But when she dates someone she changes her attitude towards us, she starts treating both of us bad. She went out with this guy only 5 times but it was like 7/8 hours long dates, yesterday they stayed out 12 hours, of which 4 parked in front of our building, and every few hours she texted so check if we were asleep. I don’t really care if they have already been intimate because she’s an adult, but I do care if I know she’s been out in cold weather and not eating, because sometimes they just walk in the park for all this time (my son and her made a “rule” to always have the location shared for a safety reason) I spoke with her and I told her “if you go out at 3pm the maximum I give you is to come back at 11pm” yesterday she stayed until 2am and 2/3 hours in front of our house. My concern is that she is really naive and quite everyone can fool her, she doesn’t want me to meet the guy so I don’t even know who he is. She thinks I try to control her, but if you are a good parent and you have such an irresponsible kid you cannot let them do everything they want, cause right now if she could she would take all the money, block us and go somewhere else with a man, and I know it cause I know my kid. I get really angry and we always fight so my son spoke with her and explained to her what is best to do to live in peace (every time we have an argument, my son tries to help us both understand each other and he tries to get the bond we used to have back, but she makes it impossible) she keeps doing how she wants so he got tired of wasting his time with two adults who should solve the problem by themselves, so he doesn’t care anymore, every time me and her argue, she just puts his headphones in and isolates form the world. I know he’s suffering, I’m as well but I really need some help on how to deal with my selfish daughter, because I love her but she doesn’t seem to care about our family…
submitted by Odd-Dragonfly-6607 to FamilyIssues [link] [comments]


2024.05.19 02:45 The_Brand94 RIGL Thesis 5/18/2024

~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD1
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.
submitted by The_Brand94 to u/The_Brand94 [link] [comments]


2024.05.19 02:44 Cham0489 Heat Induced Asthma, A/C At Work Is Broken

I work in a medical scrub store, so I have to wear scrubs; long bottoms and socks and shoes. They are very strict with the dress code. For a few weeks now the AC has not been turning on at all. The temperature only fluctuates with the temperature outside. Even if the thermostat is set to 68 in the morning, it slowly climbs up to 75 by 3pm (when I usually clock in) and it is very difficult to work and breathe for me. By the end of the shift around 7-8 it gets as high as 78. I’ve asked my manager a few times to have someone come fix it, but she says the company gets billed whenever they call someone to look at it and she’d rather wait for when the AC company comes to do their routinely checks—or wait for the regional manager or owner to worry about it when one of them come down in mid June (which I have no idea how likely it will be that they will actually come to this location by then).
I understand it costs the company money to do things like that, but it is directly affecting my asthma, and making it hard to work in here for my coworkers as well. Even the customers have started making comments on the heat in here. We have a small fan we can sit in front of behind the counter, but it still leaves me huffing and puffing (even after taking my rescue inhaler) if I have to help a customer or do something across the store. I now get light headed and feel like I’m going to pass out at work quite often, and there is no sense of relief since it is also just as hot outside.
However, I don’t want to create contention between my manager and I, since I have already brought it up to her quite a few times already, and she seems pretty adamant with her decision. But it’s really miserable at work and I don’t want to have an actual asthma attack or pass out. Another issue is, I am really sensitive to my albuterol (my rescue inhaler, I take QVAR twice daily and a singulair (montelukast) pill before bed), so my heart starts racing and I get incredibly shaky after taking it. My asthma diagnosis is also pretty new and is not very well managed right now, I’m still trying to figure out how to effectively treat it. In the end, either way, I am physically uncomfortable and there isn’t much I can do at this point—at least I don’t think. Thoughts?
submitted by Cham0489 to Asthma [link] [comments]


2024.05.19 02:44 d99271 How do I get my (24/F) boyfriend (25/M) to make me a priority again?

Hi, me (24/F) and my boyfriend (25/M) have been together for 8.5 years now. I'm really struggling in this relationship at the moment and I'm not sure what to do. I love him and I know he does love me but he's not acting like it anymore.
Basically, I'm living away from home to go to uni and my boyfriend is living in our home city in a house with his friends.
When I first got accepted, he said we would take it in turns to visit each other every 2 weeks so that there's less travel and he didn't want to go too long without seeing each other. Since I moved in September, he has come here twice (one in Dec, one in April). I come home usually 2+ times a month, sometimes for appointments but usually to see him.
When I am home, he doesn't make seeing me a priority. He will ask me to pick him up from work and drop him home but then will not be free to see me because he's doing something with his friends. At the weekend, he always has plans in the evening and does stuff with his family in the day time. He has a routine of stuff he does to keep busy, but he doesn't include me when I'm home or doesn't do something to spend time with me.
Every time I bring this up to talk about, he gets really defensive (saying he has to keep busy if not he gets sad), which I've said that's fine but id just like to spend time with you. He also then gets upset so I'm upset and the conversation stops because it breaks my heart to see him sad/cry. Or, he then uses the conversation to say what I've done recently that has upset him (he never says it at the time, always has jumped in to say this when I've brought up something I want to address).
We FaceTime every evening, apart from if he's out then any messages I send won't get a reply until the next day. But I have to reply straight away if I'm out because if not he worries.
When I brought this up last time (March), he said he would try harder and make an effort which is why he visited in April but now I keep asking when he's next coming and he says he can't.
Also last time I was home, I got my period really bad that I threw up from the pain and had was light headed all day. He came over for an hour and then left to go to the pub with his friends to watch the footie. Made me feel unimportant again.
I guess what I'm asking is how do I get him to want to make me a priority again? What should I do?
submitted by d99271 to relationship_advice [link] [comments]


2024.05.19 02:44 Senseless_vibes Pregnancy restrictions not being respected

So this is gonna be a long one. Bear with me.
Some context:: currently 32 weeks pregnant with my first child. I’m on cap1. 3 of 5 days of the week I do price changes for my store excluding fresh, deli, bakery, and apparel. The other two I’m with my team performing team tasks. 2 of 5 days of my workweek, we do not have a team lead so one of my coworkers is in charge of directing our team to get tasks done. So… herein lies the issue.
For the first two hours of our day we topstock or downstack if all of the topstock has been scanned. Because of how far along I am now, I am having a rough time with the top stocking. While I’m price changing I can change a topper if I take it slow, but the constant up and down that topstock entails is really difficult for me. I get dizzy and lightheaded every time I have to do it.
This previous week, on one of the days I normally do price changes and my team lead wasn’t working, the associate on my team who takes over for her those days CHANGED MY JOB ASSIGNMENT to top stocking.
I’m pretty timid at work, and I don’t like to cause any problems, especially considering how toxic the “mean girls” of the team are, (They’re brown nosers and shit talkers that like to make mountains out of ant hills) so I didn’t say anything and just did the topstock. I was able to complete the aisles that the coworker assigned to me, but it affected my ability to do tasks for the rest of the workday, and just generally stressed me out.
I’m honestly not sure what to do. I’m having a difficult time at work almost every day now, and it feels like my team lead and the second in command don’t GAF that I’m pregnant. I get the “you’re the one who got knocked up” vibes from both of them. I’m trying not to call off or leave early but with how exhausted I constantly feel and how much pain I’m in lately it’s inevitable I’m going to either call in or leave early at least 2x a month. I’m doing the best I can but I can’t keep up anymore.
I don’t want to take maternity leave now, because I still have 8 weeks until baby is here and I want as much time with my newborn as possible before I have to work again. Not to mention I’m honestly unsure if I’m going to return to Walmart after maternity leave, especially with how I’ve been treated since my team learned of my pregnancy.
Does anyone have any suggestions, apart from a drs note? I do have one just need to pick it up from dr office but they’re closed on weekends.
If I were to apply for short term disability, would that disqualify me from maternity leave? I just need some help. I don’t know know what the best course of action is for me to deal with these issues.
submitted by Senseless_vibes to walmart [link] [comments]


2024.05.19 02:43 stwbrry_waffles_43 Car Accident and Insurance/ What do I do?

A year and a half ago, I was in a car accident, I was 17 at the time and the passenger in the car. me and the driver were rear-ended on Main Street of our hometown. at the time there were no clear injuries so we decided not to go to the hospital, we went to work that day but the next day we were both feeling it and didn't feel good. so we decided to go to the ER and there I was diagnosed with whiplash and muscle strains. now obviously, I'm 17, I don't know anything about insurance or car accidents or claims so I left it be. my friend who was in the car accident didn't tell me a lot about the process he was going through so I have no clue as to what needed to happen. I was never spoken to by an adjuster or anybody from anyone's insurance and so I just thought that was the end of it. I had falsely assumed they would take care of my medical bill the way that they were taking care of my friends, My friend had a case and claim numbers and representative or lawyer, whatever it was, I was just glad I didn't have to go through that too. he told me about the settlement and what was going on I was like that's amazing, after how that went you definitely deserve the settlement this is been taking up so much of your life and you've been in immense pain. so my friend got all taken care of and I was still receiving medical bills, just before he had settled I told him I was receiving medical bills for this visit he said he would bring it up with his lawyer and he tried to at least once but nothing ever happened. I have called the hospital that we went to dozens of times to talk to them about this bill and tell them it wasn't my fault this should not be coming towards me and they would always say oh okay we’ll put down a note. apparently the note was never enough so one day I cracked down and I called them and I got insurance information and I got the police report I contacted both insurances, the hospital again both of the billing numbers and God knows what else. at the beginning of this year I thought it was solved because that's when I got in contact with everyone and they said will talk to the hospital we'll figure it out, soon after I received a packet from one of the insurances saying this is what we will cover, what they were willing to cover was $160 out of an almost $1,000 charge, but I had stopped receiving bills so I was like okay maybe this is taken care of because I'm barely 19,Reading the packet was a nightmare and I couldn't tell if they were saying you have to pay for the rest of this or if they were saying the hospital has to settle for $160 so I left it be. about a week ago I received another bill saying insurance has covered 160 now you have to pay for the rest. so of course I'm upset I'm distressed I barely work 25 hours a week on a good week. There's been a lot more going on with it than what is in here but I have no clue what to do, I called my father to get him involved because he's made it clear that he's willing to fight for me and help me through this but they are not receiving him any better than they received me, if anything it feels worse because he is taking the aggressive route and making it clear he has no problem with starting a lawsuit but we still have received no communication at all. this entire thing has been a terrible headache extremely distressing and upsetting. every time I get a bill not only is the amount of money overwhelming for someone who has basically nothing but the car accident itself was already really bad and every time I receive a bill the car accident is brought to the Forefront of my mind and I can just see us getting hit the car moving across the road the airbags hitting my head and getting hurt. I don't know what to do so if you have any advice please leave it in the comments. thank you.
submitted by stwbrry_waffles_43 to Insurance [link] [comments]


2024.05.19 02:42 Plotius Buried Treasure Quest did not start

I am on the Steam version of the Game
After completing From Russia with Lev the next quest Buried Treasure did not trigger to start. I didn't notice at first and when I went to go find Meg she and all the raiders who were going to help in the Raid are now gone. I checked Mysterious cave and no one is there either. I have relogged around 10 times now since yesterday when the bug occurred. Played the game normally trying to relog far away from the Crater and the Mysterious Cave. I even have a daily quest to take a photo of Meg that marks her as in the Crater interior but when I get there the marker disappears until I relog.
My current Main quests are Forging Trust, I am Become Death, Early Warnings, and Miscellaneous - Read the Night Club advertisement. I have tried abandoning the daily photo quest and relogging to see if it changes anything and it does not. Relogged on different public servers, Fallout 1st private server. Fully exiting to desktop a few times. Reinstalled the game, verified files. Checked if Meg is there on my alt and she is but not on the main account. Checked with Foundation and the main guy there is still present but I cant start any quest with him as I am locked in with Raiders.
Opened a ticket with the help support for F76 and waiting on the next response. Anything else I can do? I feel like the only fix is if some admin at Bethesda does a setstage command for the Quest like how it works in Skyrim.
submitted by Plotius to fo76 [link] [comments]


2024.05.19 02:41 dreemcast Self employment specifics

So after some research I understand I'll need to fill in a Mod F form once and a profits and losses form every 3 months. I have a couple miscellaneous questions about being self employed while receiving job seeker payments. Sorry for long post this is all pretty confusing and I'd really appreciate some insight!
1) I currently make money on Etsy as an artist but am also planning to make money on patreon for a kind of unrelated creative endeavor.
Is it fine for these things to be lumped together on the same form? As far as I understand it's fine for them to be connected to the same ABN so I assume it would be fine to lump them together on one P&L form. Is "Etsy and patreon" an acceptable answer to the "type of business" question on the P&L? Or should it be more specific like "jewelry making and online content creation"
2) thanks to medical exemptions I don't expect to have to deal with my job service provider for the next 6 months but I'm wondering what to expect from them when I have to start seeing them again.
It's my intention that eventually the combined Etsy and patreon profits will at least be the equivalent of minimum wage, part time work.
I assume if I was making that amount of money it would be enough to get them off my back and stop making me do their dumbass activities.
Though I don't expect to be at that point in 6 months, maybe I'll be about a third of the way there or so. Would they take the fact that I'm busy working on my own businesses into account or would they still demand I seek 15 hours a week of part time employment?
submitted by dreemcast to Centrelink [link] [comments]


2024.05.19 02:37 Buggy40788 Going though divorce

I am not really sure where to start or why I am writing this. I just need to get everything out...
Long...
Me (31) and my STBXH (32) have been married for 11 years and together 15 years. We have 3 elementary school kids.
He had his first affair 3 months after I had our last child. This lasted 3 years before I found out. We tried to work it out but he kept lieing and hiding things. It took a year before he told me the "whole" truth. From a drinking problem while he was alone with the kids to bring his affair partner over to the house while I worked and the kids slept. It was very hard to trust him as he refused to do anything I asked to fix the trust. Yet I was made to be the bad guy and him the victim. I have a post about the whole affair in surviving infidelity.
At the beginning of the year I thought we were getting back on track he made me homemade chocolates and got me flowers for valentine's day. That next weekend his new affair partner's baby daddy showed up at our home to confront him and make sure I knew. My daughter (5) witnessed some this before I could pull her into another room. Thankfully the other man left soon after. I asked my STBXH to leave. He said let me pack a bag and that was it. He left and went to pick up his affair partner. They ran off that night taking $900 out of our joint bank account. I put a stop to that by transferring everything to my mother's account till I could make a new one.
A week after we had a written agreement that he signed about support and parenting time. He would send $3100 a month and see the kids everyother weekend supervised. Now I did find out that his new girlfriend had ran off with her kids before disappearing for a month, so in fear of this and that her ex is claiming abuse from her I asked for supervised visits. I do believe that STBXH drinking problem was getting worse. STBXH told me not to get a lawyer we could do this cheap and peacefully. Load of BS I know now. He went back on the agreement a week later. Got a lawyer and claimed he was forced to sign that agreement. This whole time I was filling the paperwork out alone and asking him for help with the divorce. Nothing. He then said he had been talking to a lawyer. So I went out and put down a $3500 retainer on one as well.
For march he sent $1500 in child support and April $900. No court orders.
I have to admit I was a mess. Complete blindsided. This woman he ran off with is my oldest son’s best friend's mom. Lots of soccer games together and lots of sleepovers with her son at my house. STBXH never wanted our son at their house because he said it wasn't safe. I didn't know them that well. He doesn't care about the effect this has had on our oldest son and his best friend. He didn't want to tell our son but I had to force him. They are in the same class and see each other every day. The other boy already knew and our son (9) did not need to hear about how dad ran off with best friend's mom from another 9 year old.
I also found out he hid a gun in the house without me knowing. I had asked him after his first affair to remove all of them after he admitted to depression and drinking problem.
Anyway, our agreement stated 3 day notice before visitation. He didn't do this several times. He can talk to the kids every night on the phone he got them. He only talks to oldest (9) average 2 minutes most night. This past month has been soccer season and he hasn't been to a single game or practice except the last one after I refused to let him take the kids until there are court orders. He hasn't seen them in a month. He is claiming parent alienation. He even missed his last visitation no call no show.
He has bought the police to my house twice now. Once when he picked up most of his things back in February. He was afraid of the other dad showing up and possibly getting beat up. His own fault. This last time he brought the police to the house to pick the kids up and I knew he was coming so we left for my parents before he got there. Told him he could come to the kids games the next day and then to the park. I am not comfortable with him taking physical custody of the kids and having no way to get them back. The police can do nothing and i know he is only trying to bully and intimidated me in to giving the kids up. Again he has no court orders so they can do nothing. I saw him on the ring camera telling them that I am lieing to my lawyer. I'm not I have sent my lawyer a lot of proof of all my claims.
My lawyer has filed and sent in Temporary Orders and we are just waiting on a court date. No time line. I just don't know what to do. I don't trust him. It has been one lie after another. Mind games and blindsiding and playing victim. I just want all this to be over. The stress and always looking over my shoulder. I have had enough of this.
submitted by Buggy40788 to Divorce [link] [comments]


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