Synopsis:
An engineer in another world—blending science and magic to achieve greatness in a world where skills and levels reign supreme.
—
Ethan was just a plain old engineer, but everything changed when he was reborn into a world of skills, levels, and magic. With his advanced knowledge far ahead of the time period he finds himself in, this new reincarnated life will be much different than his last, especially because he can construct, deconstruct, and reconstruct runes—something no one else can do.
But with royal politics, looming tax collectors, a mountain of debt, dungeon incursions, cults, and hostile fantasy races mixing together into a cocktail of bullshit that threatens to bury his dreams; Ethan must bridge the gap between steel and sorcery to grow stronger. — Runecrafting is slow burn. — What to Expect: - Weak to very strong progression - Hardcore wish fulfillment - A balance of action, kingdom building, and runecrafting. - MC will trigger an industrial revolution, revolutionize magic, modernize agriculture, communication, commerce, textile production, education, transportation, sanitation, weapons manufacturing, leisure & entertainment, and medicine.
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Chapter 03

-1-
"Business opportunity?" Jack blinked, amused. "Intriguing. One doesn't often hear a noble propose such a thing to a [Necromancer]."
Roland shifted uncomfortably.
Ignoring him, Ethan leaned back in his chair.
"Let's just say these are unorthodox times, Jack. And frankly, the problems plaguing Holden call for equally unorthodox solutions." He gestured towards a nearby chair. "Do have a seat, and allow me to elaborate. It concerns a matter of public health, and specifically, a rather lackluster product currently on the market. One common folk cannot even afford."
Jack raised an eyebrow, taking the offered seat. "Public health and [Necromancy]? This does get more interesting by the moment, my lord."
Ethan leaned forward again.
"I'll be blunt. It's the Blight, Jack. You're undoubtedly familiar with its unpleasant effects." He wrinkled his nose slightly. "The lethargy, the nausea…and the frankly horrendous stench that clings to the afflicted."
"The Blight has stages, my lord. But yeah, I get the gist. Though, I confess, raising the recently departed isn't exactly..."
Ethan chuckled. "Not quite, my friend. While your talents with the departed are impressive, I have a different skillset in mind. One that involves cleanliness."
Jack's smile vanished, replaced by a wary arch of an eyebrow. "Cleanliness? You want a [Necromancer] for scrubbing floors?"
Ethan leaned back in his chair, steepling his fingers. "Not scrubbing floors, precisely. What do you know about the Blight, Jack?"
"It's more than a mere sickness, my lord. It's a clinging parasite that latches onto the unfortunate soul and slowly devours their life force. The early signs are subtle—a sickly sweet odor, lethargy, pale clammy skin."
Jack shuddered dramatically, and continued. "Then comes the hunger. An insatiable craving that gnaws at their insides. The victims start developing a craving for raw flesh instead. Their mere touch becomes corrupting, causing plants to wilt and wounds to fester. Disembodied whispers of the spirits torment them, sapping their willpower—they're like a sweet escape from their suffering. It chips away at their will to fight, turning them inward until they become shells of their former selves."
Ethan blinked. Jack had a knack for theatrics and being dramatic, it seemed.
"In the final stages, the body decays into a walking corpse driven by an unquenchable hunger to consume the life force of others."
"Okay, stop," Ethan raised his hand with a sigh. "Who does the Blight infect?"
Jack took a deep breath. "That's the interesting part, my Lord. The Blight only seems to affect those with little to no mana. It's like mana acts as a shield. Majority of peasants are mana-less. It's a common disease, my lord. Even nobles suffer from the Blight; mostly children given that their mana is still developing."
"So, mana is our solution?" Ethan raised an eyebrow. "Why do you think no one's arrived at this conclusion given that the Blight is such a common occurrence you'd think there'd be a cure?"
"There is a cure, my lord. But—"
"It's way too expensive."
"Indeed, that is correct, my lord."
"Regardless, our solution here is sanitation. You see, the Blight thrives in filth. The stench, the lethargy, it all stems from a miasma that festers in unsanitary conditions. It eats on people's lifeforce. And the current concoction on the market does little to combat it. There's a simple solution—people are aware of it—but sadly, it's expensive, not as effective as it should be, and frankly, an insult to hygiene."
"Oh, are you talking about soap, my lord?"
"Soap," Ethan confirmed. "More specifically, newly made soap. As soap's made with magic here, it has slight mana in it—although it's a different matter altogether that said mana dissipates. Regardless, if bought new and used, it helps with the Blight. However, we need better soap. The current offerings are woefully inadequate, and at exorbitant prices. I envision a mass-produced, affordable soap that can combat the Blight's effects, doesn't lose mana, and can invigorate people."
Jack considered this for a moment. "And why, my lord, would a noble like yourself be concerned with such mundane matters?"
"Jack," Ethan's eyes narrowed slightly, his tone turning icy. "I believe you forget yourself. It is not your place to question nobility. I suggest you remember your place and focus on the task at hand."
Jack's face turned ashen. He quickly lowered his eyes. "I apologize, my lord."
"You are forgiven." Ethan didn't particularly enjoy being a noble, but now that he was one, he needed to maintain certain boundaries.
Though Ethan had been slightly taken aback, Jack was right. Nobles seldom cared about peasants. Even less when it came to the Blight. Any and all solutions currently available for this very normal cause of death were expensive. Current brick they sold as 'soap' was inadequate, had pathetic fragrance, and performed even less when it came to hygiene. So, most peasants die due to lack of money. They couldn't buy soap, and the concoction for the Blight was too expensive.
But I don't really think like the nobles, as I am not one.
Silence stretched between the two for several long moments, and in that silence, Ethan considered the consequences.
The consequences of Ethan's plan would be far-reaching. There definitely would be a political firestorm. Soapmakers, likely well-established guilds with ties to influential nobles, would see their profits plummet and their influence challenged. They'd spread rumors about Ethan's soap being inferior or even dangerous, and might even resort to sabotage, threats, blackmail, or the like. Ethan might also face resistance from other barons who profit from the inflated price of Blight remedies.
I need to be prepared for whatever they throw at me, 'cause they definitely will.
Beyond the immediate political struggle, there could be social unrest. Slower, more expensive production methods often employ a larger workforce given that [Mages] weren't always available to make soap. There had to be a manual process discovered by the [Mages] of this world—though having tried the soap himself, it was quite lacking.
Ethan's plans for mass-produced soap could lead to unemployment among those currently making soap. He'd need to be prepared to address these concerns, perhaps by retraining displaced workers or offering them jobs in the new production facilities. Though, then again, the guilds he'd poach the unemployed people from wouldn't take it lightly.
Regardless, I need to do it. Fuck the guilds. I don't think Theo's dad will let anything happen to him—aka me now.
Theo's family was rather big. His father, Lord Alexander Lockheart, was arguably ruthless and cold, but he usually held his family's interest in his mind—knowing him and his militaristic nature, Ethan didn't doubt he'd latch onto the opportunities to make some hefty sum of money—money which he could use to fund his militaristic endeavors. The man was ambitious.
*Theo's the 4***^th child of the Lockhearts. Even aside from Theo's dad, he's got five siblings: three older and two younger siblings. Two of whom, I can easily rely on. The eldest sibling, Maximillian, or Juliana, who is the second eldest. Benson's the third child, and he doesn't like me much, so Maximillian and Juliana are my only hope—though they're kind of disappointed in how Theo behaved, they wouldn't let something happened to me*, especially knowing that I, "Theodore Lockheart", am turning over a new leaf. Not to mention Theo's mom's too soft.*
Knowing his safety wouldn't be an issue, Ethan looked at Jack. He had only spoken like Theo to make sure he could set a proper boundary with Jack. Deciding that the awkward silence had gone for far too long, he spoke with a lighter tone.
"Though, if you must know, the Blight doesn't discriminate. It cripples the poor, yes, but it also weakens soldiers and undermines trade. A healthy populace is a productive populace, one that can pay taxes and contribute to the well-being of the entire barony. Besides," he added, a sly smile returning, "imagine the profit. Affordable, effective soap for all? It would be a goldmine. I'm especially looking forward to the reaction of noblewomen. They'll be in a frenzy. They'll be begging for this soap. We'll be swimming in coin."
Which I need given the looming tax and Holden's fucked up financial situation...
Unaware of what was going through Ethan's mind, Jack tapped his chin thoughtfully. "And, with all due respect, my lord, why do you need my help? What possible use could a [Necromancer] have in the realm of soap-making?"
Ethan leaned back, a smile playing on his lips. "While your skills in manipulating life force are undoubtedly impressive, Jack, it's your less publicized talent I'm particularly interested in."
Jack's eyes narrowed for a moment. "You mean...?"
"Imbuement." Ethan said.
Ethan wasn't too sure, but given that [Necromancers] and [Witches] were infamous classes, he'd heard rumors. They often imbued objects. Corpses in [Necromancers'] case and certain objects in [Witches'] case. It wasn't mana that they imbued exactly, but something else—which he had no clue about—that let them have control over the corpse/object they imbued. But, given that these two classes were the most affordable ones that could imbue anything at all and were experts in that regard, Ethan was pretty sure Jack could achieve his goal.
That was his theory, of course. It all depended on how long they could hold the mana inside the soap. Making the soap affordable and high quality—that he could handle. Keeping the mana within it, though, and getting some decent returns? Well, that depended a lot on Jack.
Jack ran a nervous hand through his scraggly brown hair, his eyes glinting.
"What if we could imbue the soap with mana?" Ethan said. "It would disrupt the Blight's ability to feed on life force. Think of it as a sort of 'static' that interferes with the Blight's 'signal'. So, we imbue mana into soap."
Jack frowned, considering this. "That's an interesting idea, my lord. But how would we create such a thing? Soap is expensive to make; you would have to employ mages—"
"Leave the soap to me. Deal with imbuing mana instead. As a [Necromancer], you have a unique understanding of life force and how it can be manipulated. I believe that with your help, we can develop a method to imbue soap with mana that stays in for as long as possible—you are the expert in imbuement, after all. The soap would then not only clean the body, but also create a sort of protective barrier against the Blight." He leaned back in his chair, watching Jack's reaction closely. "So, what do you think? Are you up for it?"
-2-
Ethan hummed as the carriage came to a stop near the house where those infected by the Blight were being kept under quarantine, in the company of Roland. The house wasn't luxurious by any means, it was quite small really. But it had been secured to allow them to observe the tainted. Ethan exited the carriage along Roland and Jack, and soon they were greeted by a tall, slender man in robes.
"Ah, Lord Theodore. It is my utmost pleasure to meet your esteemed self." the robed man bowed. His voice was even, but there was a wariness there—clearly, the man was not comfortable dealing with Ethan, or more like, Theodore who was infamous for his... nature.
Ethan wasn't happy with how the people of Holden and everyone acquainted with Theo regarded him, a reputation that likely spread more than just this town, but he couldn't do anything about it. Logically, he'd just need to deal with it one step at a time.
"No need to be so tense... Sir Miller." Ethan briefly checked his memory to bring up the information of the man.
Miller was the head physician of Holden.
"Esteemed guest," The man was still bowing, clearly uncomfortable and unable to bring himself to stand straight before a notorious lord such as Theodore. "Do not concern yourself with trivial manners and come in. The tainted have been secured, and preparations made, so please, this way."
The man led Ethan inside and after crossing through an empty room, they reached a space sectioned off by iron grills. A group of men armed with spears surrounded the door from the outside—they were armed with spears so they could deal with anyone that reached the third stage and became a brain-dead zombie without getting near them. The tall and burly men eyed Roland and Ethan, on alert at a noble's presence.
Ethan covered his face in a mask, stepped over the grills, into the open hall with rows of beds lining both sides, where about ten people lay, most on their back. If they noticed their Lord, the people lying on the bed didn't act like they noticed anything. "Please, Lord Theodore...!" Miller said. "You mustn't get near!"
"Nothing to worry, I won't be tainted," Ethan said. He was a [Mage] after all, and unranked one, but a mage nonetheless. He looked at the patients one by one.
They do look sickly... it is one thing hearing about it, but this is far more eye opening... Sighing, Ethan turned around and walked out.
"Jack, do your thing."
"Yes, my lord." Jack said as Ethan made it to Roland.
"Roland, we need to go to the Deadwoods, you and I."
Roland appeared apprehensive but did not question Ethan's intentions.
As Ethan and Roland walked out, Jack got started on the subjects. Ethan looked ahead. Grassy meadows stretched far and wide, dotted by occasional trees and bushes. The sun's golden rays washed over the land, leaving an orange tinge on the distant mountains. To the west of Holden lay the Deadwoods—easily spotted, as it stood as an ominous expanse of darkness in the otherwise brightly lit region. A mountain range stretched behind the Deadwoods and clung to the earth, meeting the borders of Corinth.
Ethan had to admit, the place was a sight to see despite how much the Deadwoods stood out like a sore thumb amidst all this greenery. Even then, the Deadwoods held a unique allure. Ethan got into the carriage with Roland in tow, then with a light jolt the carriage started moving. It was being pulled by two horses.
"With all due respect, my Lord, this seems unwise, no?"
"It'll be fine," Ethan reassured. "We have guards with us, and I have you to protect me."
"Why, is it not better to simply let us know what you require so we may fetch it in your stead?"
Ethan smiled, but didn't answer.
The Deadwoods soon came closer as the carriage sped up, drawing near to a stretch of meadows with trees scattered every few paces or so.
The carriage rattled as it went over a particularly large bump. Ethan gave a quick glance at Roland—the man had grown quieter since their departure. Clearly, he was contemplating what sorts of heinous plans his new lord had in store.
Suddenly, the carriage lurched to a halt. Ethan poked his head out of the window and called, "What's the hold-up?"
The driver gave an apologetic bow. "There's a large rock in the road, my lord."
"Then have the guards get rid of it." Ethan's voice carried a subtle note of annoyance. He really didn't have time for delays—as a rule of thumb, he usually hated them.
"My lord," Roland said. "It's a trap. We're under attack."
An arrow slammed right beside Ethan's head the next instant.
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Earlier today about six hours ago, I spilled some Lysol laundry sanitizer on the floor. He immediately ran over to it and I think it got on his fur. I wiped it off with a wet paper towel and he seemed fine. The last few hours he’s been acting a little lethargic and drooling.
I called the emergency vet and she said if I brought him in, they would just give him some anti nausea medicine and maybe some fluids but that’s it. I have some anti nausea medicine for him because he tends to have a sensitive belly. I gave him some of it but it doesn’t seem to be helping. The vet said if he gets worse to bring him but I can’t tell if he’s getting better or staying the same. Should I just bring him in to the vet?

not asking if i’m pregnant!! i don’t think i am! some backstory: the end of last summer i was having serious abdominal pain and thought i had a cyst or something. went and got an internal ultrasound and it showed “pelvic congestion” but nothing serious. my gyne said they thought i had endometriosis and wanted to schedule me a surgery to find out. i didn’t want to do that so i went to another dr to get a second opinion, they said they didn’t think it was endometriosis but just pelvic problems. i got off of my birth control pills because i thought that’s what was causing my pain. pain mostly stopped, would occasionally come back but never super severe. after almost a year of being off of birth control the pain has come back and it’s traveling into my back and down my left leg. i completely skipped my period in april, i was given three different pregnancy tests at my dr which all came back negative and i’ve taken like 10 at my house. all negative i even took a digital one. my gyne prescribed me Medroxyprogesterone to start my period so i could start a different type of birth control to hopefully help with the pain i’ve been experiencing. ive been taking this medicine for almost a week and still no period. i’m having severe pain and nausea (only with the pain) i have no clue what is happening with my body. help

I felt the need to post here because I am beyond over going to multiple doctors. Starting last year I kept getting "UTI's". The reason I put that in quotes is because I would come in with frequent urination, lower abdominal pain, nausea, and lower back pain. Every time they diagnosed me with a "UTI" they would give me medicine and send it for culture. I would call back the doctor and tell them my symptoms were worse (frequent urination and pelvic pain) and they would say "well nothing has grown in your culture, you didn't have a UTI". This went on about 5-6 times and I was over it. When I started to get the symptoms I would just tough through (even if they had me bent over, up all night, or crying in so much pain). As this was going on I woke up in the middle of the night one night and started having extreme lower abdominal pain and nausea. My boyfriend made me go to the hospital. They took a CT scan and said everything came back normal so the doctor brushed it off and said it was probably a kidney infection and sent me home with meds. He also said I had a small ovarian cyst but it was so tiny it was nothing to worry about, just follow up with gynecology for both the kidney infection and the cyst. I took the pills he prescribed thinking that maybe that was it. Nope. I went to my gyno and she diagnosed me with PCOS and told me to get back on birth control. I got back on and was still having the same symptoms. A month later I started vomiting like the exorcist. Fluid coming out of my nose and everything. About 12 hours had passed and the vomiting would not stop. Worried about dehydration my boyfriend took me to the hospital again. They said my cyst was gone and could have ruptured(but again it wasn't big enough to be concerning/even cause those symptoms). They also checked my gallbladder-nothing. I stayed for 3 nights in the hospital because I couldn't stop vomiting and I was severely dehydrated. At this point once I was hydrated they sent me home with a big question mark/brushed it off AGAIN. They told me I needed to follow up with a gastro doctor. So I did. They looked for H-pylori, ulcers, and did multiple scans. NOTHING. My symptoms would come and go. I would have frequent urination, abdominal pain, intense vomiting etc. They refused to do an endoscopy on me because I had latent TB (f-ing ridiculous) and told me I need to get treatment before they did one. IMAGINE LITERALLY BEING HOOKED UP IN THE SURGERY CENTER TO IV DRUGS AND THEY ARE ABOUT TO ROLL YOU INTO YOUR ENDOSCOPY AFTER YOU PAID 2K+ AND TOOK OFF WORK AND THE DOCTOR SAYS "STOP WE CANT DO THIS YOU HAVE LATENT TB". (I found out months later after getting into a TB specialist that this was complete BS and my specialist was extremely upset with how the doctor refused the endoscopy. ) After this, he brushed it all off and told me I had "functional dyspepsia". Again I put this in quotes because who tf knows if this is even my real diagnosis. During this time I got off the birth control against my gyno at the ties reccomendation. They had prescribed me multiple different ones because they were making me feel super anxious, I was gaining weight, ect. I went super holistic mode and did my research before I got off. I quit drinking, caffeine, quit processed foods, juiced, etc. While this is going on I go see my PCP and am STILL having frequent urination and pelvic pain. She refers me to a uro/gyno specialist and I wait 2 months to get off their waiting list/finally have an appointment. When I was at the appointment they said I had another "UTI" and later confirmed that through culture there was no UTI. They didn't get why I was having pelvic pain and brushed it off. They also performed a cystoscopy and found a lump in my bladder but did not biopsy it. They sent me for a CT scan and said the lump was probably just constipation. And that I also had two large cysts. I believe the biggest was 6.5ish cm from what she told me. Its funny because I am now currently vomiting again and just found out this news today at the doctor about the cyst. She told me she isn't concerned and that will get imaging in a couple months. She brushed off all my fake UTI diagnoses, said the lump was probably constipation, gave me a IC-smart diet (even though I told her I have been pretty much dieting this whole time) and if I had pain to just go to the ER. I wanted to just cry right there but god forbid you do they think your crazy!!! I am in the healthcare field and I see I all the time. But I swear I am not crazy, these are real symptoms and I'm a real freaking person!!! Do you think I want to miss work constantly and pay thousands of dollars to hear this shit for FUN?? NOOO not freaking me. I feel so unlistened to and I am so over it. I am reaching out here. I have looked up these symptoms and the only thing I'm finding is ovarian cancer. I don't know what steps to take next. Is anyone else experiencing this or have experienced this? I cant help but feel like these two symptoms are linked. I feel like giving up but I know something just doesn't feel right and taking a zofran for the random "functional dyspepsia", a pill for a "UTI", and just brushing it off while I'm in pain up all night and randomly vomiting just doesn't feel right. Someone please help me/let me know what steps I should take next.

Hey guys,
I've had costochondritis since July of 2023 but didn't get medicine to treat pain and sleep until Thanksgiving of that year. They gave me 500 mg of Naproxen and 10 mg of Flexeril. I didn't take the Naproxen every day unless I needed it but with Flexeril, I took it every night because it helped me with my sleep which helped me work and do school work better. This sucks now because even though I knew it was bad to take more than three weeks it was helping me get through normal life. I called the doctor (not my primary care doctor since she was full) to see how to quit and they just said just stop. When I stopped at the end of March I got horrible symptoms like headache, shivering, sweating, nausea, dizziness, weakness, and lightheadedness. When I told my doctor (my actual doctor) they then recommended me to go back on except cut it in half to 5 mg. This after a week my symptoms improved a lot.
I guess the point of this post is just to rant a bit because I am a little scared of the tapering process since now I'm down to 2.5 mg for a week so far at the time of writing this post. The withdrawal symptoms aren't as bad as when I stopped cold turkey but they do still scare me, such as the nausea. I still have costochondritis but it has significantly improved since I've been using the backpod. But I do get anxious thoughts about vomiting and making Costo worse again since this is the best I've felt in a long time.
If anyone has successfully got off long-term Flexeril usage how did it go for you and was the plan schedule exactly? What were your symptoms?
Also, tell me about your experience with Costo or the Backpod usage. I heard if you use it long enough it can cure Costo. And apologies if this post comes as whiny this condition just sucks.

Skullcap Questions
Skullcap Questions
Long story short, I have had an extreme case of chronic nausea without a clear ongoing cause for over two years (I've had an extreme amount of testing from top flight doctors). I've tried an endless list of medications, natural supplements, alternative medicine (i.e. acupuncture and hypnotherapy), lifestyle modifications, different diets, etc., and nothing really works.
I just bought skullcap, valerian root and passionflower extract in tincture form. I did so in the very slightest of hopes that they may help, as chronic nausea and functional GI issues are treated with neuromodulators (and these herbs appear to somewhat be neuromodulators). I also read that skullcap could have anti-spasmodal effects. I know all three of these are typically used for anxiety, and although I don't have an anxiety disorder, my neurogastrointerologist told me these conditions stem from a very similar or nearby area in the brain (which is what convinced me to try to prescription neuromodulators, which were not very effective).
My questions are:
-What dosage should I use for skullcap?
The Nature's Answer bottle suggests 2ml (or 665 mg) 3 times per day. I just tried one dose.
-How long before I see the benefits (if any) for the herb to reach maximum potential (and if no material benefits, after how many days should I stop trying it)?
-Is there an amplified benefit to combining with Valerian Root and/or Passionflower (and if so, please provide dosages)?
-Are the latter herbs better than skullcap for my intended purpose?
I know this is 100% a blind shot in the dark for my condition, but i want to give every conceivable treatment a proper try.

Long story short, I have had an extreme case of chronic nausea without a clear ongoing cause for over two years (I've had an extreme amount of testing from top flight doctors). I've tried an endless list of medications, natural supplements, alternative medicine (i.e. acupuncture and hypnotherapy), lifestyle modifications, different diets, etc., and nothing really works.
I just bought skullcap, valerian root and passionflower extract in tincture form. I did so in the very slightest of hopes that they may help, as chronic nausea and functional GI issues are treated with neuromodulators (and these herbs appear to somewhat be neuromodulators). I also read that skullcap could have anti-spasmodal effects. I know all three of these are typically used for anxiety, and although I don't have an anxiety disorder, my neurogastrointerologist told me these conditions stem from a very similar or nearby area in the brain (which is what convinced me to try to prescription neuromodulators, which were not very effective).
My questions are:
-What dosage should I use for skullcap?
The Nature's Answer bottle suggests 2ml (or 665 mg) 3 times per day. I just tried one dose.
-How long before I see the benefits (if any) for the herb to reach maximum potential (and if no material benefits, after how many days should I stop trying it)?
-Is there an amplified benefit to combining with Valerian Root and/or Passionflower (and if so, please provide dosages)?
-Are the latter herbs better than skullcap for my intended purpose?
I know this is 100% a blind shot in the dark for my condition, but i want to give every conceivable treatment a proper try.

This week I moved up to 7.5 (Thursday). On Saturday, I started feeling some slight fluttering of my heart, probably palpitations, and so I checked my Apple Watch and my heart rate was increased. During the times that my heart rate would increase I would get a hot flash immediately after. No nausea or anything.
Has anybody experienced this while raising their dose? Does this sound like a result of the medicine?
I suppose this could be perimenopause. I’m 45. But I will say if it is… this is my first time getting hot flashes if so. The worst day was Saturday, and I was extremely fatigued as well.
Yesterday and today I seem to be doing much better, but I have had moments where I still feel a little bit off.
I’d love to hear if anyone else has experienced this while raising their dose. Also, even if you’re not a female, what were your experiences when you raised a dose and maybe it felt like you went a little bit too high?
Just to reiterate, this is my first week of 7.5 IDK if the dose was too high or not. I’m just trying to figure out what’s going on.

I've been reading all the posts for the last three weeks, but I think I need to just ask my question. I'm only three weeks in on the. 25 dose. Took my first dose on a Friday. The following Wednesday I was super nauseous and developed strong abdominal pain. This lasted two days. Took my next dose on Friday. Following Wednesday the nausea and abdominal pain was so bad that I was sent home from work and spent that night on the bathroom floor. I don't vomit, but let me tell you, I recreated the famous exorcist scene over and over. Not to mention the diarrhea I had since the previous Saturday. I lost seven pounds in one night from expelling all the demons within. The abdominal pain was so much worse the second Wednesday around that I'm still recovering from it. I took my third dose yesterday so that of I have the same effects it won't be during the work week, and changed the spot from stomach to arm. If I end up blowing up from both ends again in the worst abdominal pain that nothing can help again, should I just realize the side effects are too much for me? Also I was taking gravol, Metamucil, immodium and pepcid ac(the heartburn was real). Trying to get more fibre and protein with less crap ingredients since starting shots as well. Will I become used to the medicine or understand it's not for me? This is my rant question. Thank you for coming to my TedTalk.

I want to share my gastritis experience with you guys and hopefully it can help someone.
At around February of 2023 I had a very sharp pain in between my chest plate and abdomen area that lasted for about 2-3 hours in the night. At first I thought it was a muscle I pulled.
The pain came around again about 2-3 months later around the same of day. Then again a week later and then again days after. One night I came home from work and ate some chicken burritos with raw white 🧅, cilantro, sour cream and a little bit of salsa. About an hour later, the pain started kicking in and it lasted for 8 hours almost (12 @ midnight to 8 in the morning.) Including nausea and vomiting.
So I headed to the hospital, straight to the ER. They were doing ultra sounds and believed for it to be my gallbladder (gallstones.) They gave me shot glass of some sort of medicine and within less than a minute the pain was numb, but I was still dealing with the back pain from the gastritis attack. They had me sitting in the IV room trying to play me to take an IV and to see if I needed surgery to remove my gallbladder but none of the systems I had was relating to gallstones, they were all relating to gastritis. So I’m going at it with the IV nurse to call the doctor in. He comes in and tells me, “So I heard you want to go home.”
I said, “Yes, because you guys haven’t offered no medicine, no diet plans, nothing. Just straight surgery.” So he told me to just avoid chocolate, citric foods, tomatoes, spicy foods, raw onion, carbonated drinks, tomato sauce. I was so physically and mentally drained from the day I ended up leaving and going back home. As I was doing my research I came across a way to reduce the pain or stop a gastritis attack when you feel like it’s occurring. When you feel like a gastritis attack is occurring eat bread and saltine or unsalted crackers, or you can choose one or the other.
You know how when you pour sand on to a small puddle or spot of water and it absorbs everything? Think of it like that when you eat crackers and it goes into your stomach. The crackers (and bread) is absorbing majority of the acid that your stomach is producing to calm it down and not put you into pain (or make it worse.)
Hope this helps.

When our characters suffer addiction we know little about we should look up these different things to add into the description of the traits to provide more depth and reality to them. It makes it more three dimensional and can build into different subplots that are integrated into a larger storyline.
Here are just a few of the things people are addicted to and how those addictions are manifested into traits that are part of a full character profile.

1. Alcohol:
   
   • Dependence
   • Craving
   • Tolerance
   • Withdrawal symptoms
   • Loss of control
2. Tobacco:
   
   • Nicotine dependence
   • Habitual use
   • Respiratory issues
   • Withdrawal symptoms
   • Health deterioration
3. Cocaine:
   
   • Intense euphoria
   • Increased energy
   • Agitation
   • Paranoia
   • Rapid heart rate
4. Heroin:
   
   • Euphoria
   • Drowsiness
   • Needle marks
   • Respiratory depression
   • Nausea
5. Marijuana:
   
   • Altered perception
   • Memory impairment
   • Lack of coordination
   • Dependence
   • Impaired judgment
6. Prescription opioids:
   
   • Pain relief
   • Sedation
   • Dependence
   • Tolerance
   • Respiratory depression
7. Benzodiazepines:
   
   • Anxiety relief
   • Sedation
   • Dependence
   • Withdrawal symptoms
   • Memory impairment
8. Methamphetamine:
   
   • Increased alertness
   • Euphoria
   • Agitation
   • Psychotic symptoms
   • Cardiovascular issues
9. Gambling:
   
   • Compulsive behavior
   • Financial losses
   • Obsessive thoughts
   • Relationship strain
   • Chasing losses
10. Video games:
    
    • Escapism
    • Social isolation
    • Obsessive gaming
    • Impaired daily functioning
    • Disrupted sleep
11. Social media:
    
    • Constant checking
    • Fear of missing out (FOMO)
    • Validation-seeking behavior
    • Time distortion
    • Negative impact on mental health
12. Internet:
    
    • Excessive online time
    • Cyber addiction
    • Social disconnection
    • Impact on real-life relationships
    • Compulsive browsing
13. Shopping:
    
    • Compulsive buying
    • Financial strain
    • Temporary emotional relief
    • Hoarding tendencies
    • Impaired financial decision-making
14. Work:
    
    • Workaholism
    • Neglect of personal life
    • Burnout
    • Constant need for achievement
    • Difficulty delegating tasks
15. Exercise:
    
    • Compulsive exercising
    • Exercise as a primary source of identity
    • Physical strain
    • Disregard for rest and recovery
    • Negative impact on mental health
16. Food:
    
    • Binge eating
    • Emotional eating
    • Loss of control
    • Negative body image
    • Compulsive overeating
17. Sugar:
    
    • Craving for sugary foods
    • Energy crashes
    • Weight gain
    • Increased risk of health issues
    • Difficulty moderating intake
18. Coffee:
    
    • Caffeine dependence
    • Increased tolerance
    • Physical withdrawal symptoms
    • Disrupted sleep
    • Jitters and restlessness
19. Tea:
    
    • Caffeine dependence
    • Ritualistic consumption
    • Calming effect
    • Impact on hydration
    • Withdrawal headaches
20. Energy drinks:
    
    • Excessive caffeine intake
    • High sugar content
    • Stimulant-induced alertness
    • Potential health risks
    • Dependency for energy boost
21. Sex:
    
    • Compulsive sexual behavior
    • Relationship strain
    • Risky sexual activities
    • Obsessive thoughts
    • Impact on daily functioning
22. Pornography:
    
    • Excessive consumption
    • Escapism
    • Distorted views of relationships
    • Impact on sexual health
    • Relationship strain
23. Prescription medications:
    
    • Dependence on medication
    • Over-reliance
    • Impact on physical health
    • Potential for misuse
    • Tolerance
24. Codeine:
    
    • Pain relief
    • Sedation
    • Dependence
    • Respiratory depression
    • Misuse potential
25. LSD:
    
    • Altered perception
    • Hallucinations
    • Distorted sense of time
    • Potential for psychological distress
    • Flashbacks
26. MDMA (Ecstasy):
    
    • Increased empathy
    • Euphoria
    • Dehydration
    • Hyperactivity
    • Potential for overheating
27. Ketamine:
    
    • Dissociation
    • Hallucinations
    • Impaired motor function
    • Dependence
    • Bladder and urinary issues
28. Inhalants:
    
    • Euphoria
    • Dizziness
    • Short-term hallucinations
    • Potential for brain and organ damage
    • Sudden sniffing death
29. Caffeine:
    
    • Stimulant effects
    • Dependence
    • Withdrawal headaches
    • Increased heart rate
    • Insomnia
30. Nicotine:
    
    • Stimulant effects
    • Dependence
    • Withdrawal symptoms
    • Increased heart rate
    • Respiratory issues
31. Sex:
    
    • Compulsive sexual behavior
    • Relationship strain
    • Risky sexual activities
    • Obsessive thoughts
    • Impact on daily functioning
32. Pornography:
    
    • Excessive consumption
    • Escapism
    • Distorted views of relationships
    • Impact on sexual health
    • Relationship strain
33. Prescription medications:
    
    • Dependence on medication
    • Over-reliance
    • Impact on physical health
    • Potential for misuse
    • Tolerance
34. Codeine:
    
    • Pain relief
    • Sedation
    • Dependence
    • Respiratory depression
    • Misuse potential
35. LSD:
    
    • Altered perception
    • Hallucinations
    • Distorted sense of time
    • Potential for psychological distress
    • Flashbacks
36. MDMA (Ecstasy):
    
    • Increased empathy
    • Euphoria
    • Dehydration
    • Hyperactivity
    • Potential for overheating
37. Ketamine:
    
    • Dissociation
    • Hallucinations
    • Impaired motor function
    • Dependence
    • Bladder and urinary issues
38. Inhalants:
    
    • Euphoria
    • Dizziness
    • Short-term hallucinations
    • Potential for brain and organ damage
    • Sudden sniffing death
39. Caffeine:
    
    • Stimulant effects
    • Dependence
    • Withdrawal headaches
    • Increased heart rate
    • Insomnia
40. Painkillers:
    
    • Pain relief
    • Tolerance
    • Dependence
    • Risk of overdose
    • Respiratory depression
41. Sleeping pills:
    
    • Sedation
    • Dependence
    • Tolerance
    • Impaired cognitive function
    • Disrupted sleep patterns
42. Compulsive lying:
    
    • Habitual dishonesty
    • Concealing the truth
    • Strained relationships
    • Loss of trust
    • Need for constant validation
43. Plastic surgery:
    
    • Body dysmorphic tendencies
    • Constant pursuit of perfection
    • Psychological impact
    • Financial strain
    • Societal pressure
44. Cutting/self-harm:
    
    • Coping mechanism
    • Emotional release
    • Negative emotions relief
    • Risk of infection
    • Concealing scars
45. Powecontrol:
    
    • Manipulative behavior
    • Desire for dominance
    • Strained relationships
    • Lack of empathy
    • Fear-based control
46. Fame:
    
    • Constant pursuit of recognition
    • Validation-seeking behavior
    • Impact on mental health
    • Shifting priorities
    • Loss of privacy
47. Attention:
    
    • Constant need for validation
    • Disregard for personal boundaries
    • Impact on relationships
    • Social media-centric behavior
    • Self-worth tied to attention
48. Sugar-sweetened beverages:
    
    • High sugar content
    • Increased calorie intake
    • Weight gain
    • Tooth decay
    • Dependency on sugary drinks
49. Fast food:
    
    • High-fat content
    • High calorie intake
    • Dependence on convenience
    • Weight gain
    • Negative impact on health
50. Selfies:
    
    • Constant need for self-documentation
    • Validation-seeking behavior
    • Impact on self-esteem
    • Comparison to others
    • Social media-centric behavior
51. Cosmetic procedures:
    
    • Desire for physical enhancement
    • Psychological impact
    • Financial strain
    • Body dysmorphic tendencies
    • Societal pressure
52. Hoarding:
    
    • Compulsive accumulation of possessions
    • Difficulty discarding items
    • Impaired living space
    • Emotional attachment to objects
    • Strained relationships
53. Overeating:
    
    • Binge eating episodes
    • Emotional eating
    • Loss of control
    • Negative impact on physical health
    • Guilt and shame
54. Prescription stimulants:
    
    • Increased alertness
    • Improved focus and concentration
    • Dependence
    • Tolerance
    • Potential for misuse
55. Over-the-counter drugs:
    
    • Self-medication
    • Potential for misuse
    • Dependency
    • Health risks
    • Lack of professional guidance
56. Romantic relationships:
    
    • Codependency
    • Obsessive thoughts
    • Fear of abandonment
    • Emotional highs and lows
    • Strained personal identity
57. Codependency:
    
    • Excessive reliance on others
    • Neglect of personal needs
    • Difficulty setting boundaries
    • Fear of rejection
    • Strained relationships
58. Social approval:
    
    • Constant need for validation
    • Fear of judgment
    • Impact on self-esteem
    • Conforming behavior
    • Social media-centric validation
59. Thrill-seeking:
    
    • Constant pursuit of excitement
    • Risk-taking behavior
    • Impaired judgment
    • Adrenaline dependence
    • Impact on personal safety
60. Narcotics:
    
    • Pain relief
    • Sedation
    • Dependence
    • Tolerance
    • Health risks
61. Designer drugs (e.g., bath salts):
    
    • Intense euphoria
    • Hallucinations
    • Agitation
    • Increased heart rate
    • Severe health risks
62. Over-the-counter cough medicine abuse:
    
    • Euphoria
    • Dizziness
    • Hallucinations
    • Impaired coordination
    • Health risks
63. Social media stalking:
    
    • Compulsive checking of profiles
    • Intrusive thoughts
    • Obsessive behavior
    • Impact on mental well-being
    • Strained personal relationships
64. Fear of missing out (FOMO):
    
    • Constant need to be involved
    • Anxiety about social events
    • Comparison to others
    • Impact on mental health
    • Social media-centric anxiety
65. Collecting:
    
    • Compulsive acquisition of items
    • Difficulty discarding possessions
    • Emotional attachment to collections
    • Strained living space
    • Financial strain
66. Fantasy sports addiction:
    
    • Excessive time spent on fantasy sports
    • Impact on work or relationships
    • Obsessive tracking of player stats
    • Financial investment
    • Escapism from reality
67. Conspiracy theories obsession:
    
    • Constant consumption of conspiracy content
    • Alienation from mainstream information
    • Impact on critical thinking
    • Strained relationships
    • Difficulty accepting evidence-based information
68. Extreme diets:
    
    • Obsessive focus on dieting
    • Impact on physical health
    • Emotional distress related to food
    • Social isolation due to dietary restrictions
    • Negative body image
69. Extreme couponing:
    
    • Compulsive pursuit of discounts
    • Hoarding of coupons
    • Excessive stockpiling of items
    • Impact on financial well-being
    • Strained living space
70. Internet trolling:
    
    • Habitual provocative online behavior
    • Seeking emotional reactions
    • Anonymity-driven aggression
    • Strained online communities
    • Legal consequences
71. Spiritual bypassing:
    
    • Avoidance of negative emotions through spirituality
    • Denial of personal challenges
    • Strained relationships
    • Lack of emotional authenticity
    • Disconnect from reality
72. Extreme minimalism:
    
    • Compulsive decluttering
    • Obsessive focus on possessions
    • Strained relationships due to minimalistic lifestyle
    • Anxiety about material belongings
    • Rigidity in lifestyle choices
73. Gaming loot box addiction:
    
    • Compulsive spending on in-game purchases
    • Chasing virtual rewards
    • Financial strain
    • Impact on real-life responsibilities
    • Gambling-like behavior
74. Rumination:
    
    • Constant overthinking
    • Obsessive focus on past mistakes
    • Impact on mental health
    • Difficulty moving forward
    • Strained relationships
75. Approval-seeking behavior:
    
    • Constant need for validation
    • Fear of rejection
    • Impact on decision-making
    • Strained authenticity
    • Mental health implications
76. News addiction:
    
    • Compulsive consumption of news
    • Anxiety related to current events
    • Impact on mental well-being
    • Difficulty disconnecting from news cycle
    • Strained worldview
77. Anger addiction:
    
    • Habitual anger expression
    • Seeking confrontation
    • Strained relationships
    • Negative impact on mental health
    • Legal consequences
78. Religious zealotry:
    
    • Extreme devotion to religious beliefs
    • Intolerance of other perspectives
    • Strained relationships with non-believers
    • Willingness to harm others in the name of faith
    • Resistance to critical thinking
79. Mindless scrolling:
    
    • Excessive time spent on scrolling through content
    • Impact on productivity
    • Impaired attention span
    • Social isolation
    • Disrupted sleep patterns

A new review of the science around the components of marijuana says the “complex interaction between phytocannabinoids and biological systems offers hope for novel treatment approaches,” laying the groundwork for a new era of innovation in cannabis-based medicines.
Among other takeaways, the report, published earlier this month in the International Journal of Molecular Sciences, underscores the potential of whole-plant cannabis medicine—incorporating the variety of cannabinoids, terpenes and other compounds produced by the cannabis plant—rather than simply THC or CBD on their own.
“The plant Cannabis exhibits an effect called the ‘entourage effect’, in which the combined actions of terpenes and phytocannabinoids results in effects that exceed the sum of their separate contributions,” the study says. “This synergy emphasizes how important it is to consider the entire plant when utilizing cannabinoids medicinally as opposed to just concentrating on individual cannabinoids.”
A new review of the science around the components of marijuana says the “complex interaction between phytocannabinoids and biological systems offers hope for novel treatment approaches,” laying the groundwork for a new era of innovation in cannabis-based medicines.
Among other takeaways, the report, published earlier this month in the International Journal of Molecular Sciences, underscores the potential of whole-plant cannabis medicine—incorporating the variety of cannabinoids, terpenes and other compounds produced by the cannabis plant—rather than simply THC or CBD on their own.
“The plant Cannabis exhibits an effect called the ‘entourage effect’, in which the combined actions of terpenes and phytocannabinoids results in effects that exceed the sum of their separate contributions,” the study says. “This synergy emphasizes how important it is to consider the entire plant when utilizing cannabinoids medicinally as opposed to just concentrating on individual cannabinoids.”
[Using Marijuana Before Working Out Can Enhance Enjoyment And ‘Runner’s High’]()0 of 1 minute, 4 secondsVolume 0%Loading ad
Much of the 23-page report—from pharmacy researchers at Ovidus University of Constanta and the University of Medicine, Pharmacy Science and Technology of Târgu Mures, both of which are in Romania—comprises an overview of cannabinoids, including THC and CBD as well as cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN) and tetrahydrocannabivarin (THC-V)—as well as how those compounds appear to interact with the human body.
While the vast majority of research has studied THC and CBD, the new review notes that the “exploration of novel phytocannabinoids is rapidly evolving, offering exciting prospects for future therapeutic applications.”
“Beyond well-established compounds like THC and CBD, the quest for novel cannabinoids widens the scope of potential treatments,” it says. “Each cannabinoid, with its unique chemical structure, interacts differently with the [endocannabinoid system], suggesting tailored therapeutic effects for specific conditions. This exploration seeks to harness similar benefits while circumventing associated drawbacks.”
Each of the chemical components has specific effects, which the study briefly describes. The broad review, which cites nearly 100 other sources, acknowledges that some effects are bolstered by robust scientific evidence, while others are still being explored.
THC, for example, has demonstrated analgesic effects, authors wrote. “It also possesses antiemetic effects, which make it useful for chemotherapy-induced nausea and vomiting.”
CBD, meanwhile, has demonstrated anti-inflammatory properties and “is said to have analgesic properties and may be effective in pain management.” Some research also shows the cannabinoid may have neuroprotective qualities.
While CBD formulations like the prescription drug Epidiolex can treat rare forms of epilepsy, mixes of CBD and THC may help address spasticity related to multiple sclerosis, the paper says.
Both THC and CBD also have antioxidant effects, it adds, and both appear to be promising tools for a variety of ailments, from pain to neurological disorders and psychiatric conditions.
Further, CBD may help reduce symptoms of anxiety and PTSD, while both THC and CBD may exhibit antidepressant effects. “While some findings suggest that cannabinoids may have mood-stabilizing effects and enhance serotonin signaling, the evidence is inconclusive, and further research is needed,” the study says.
CBD may also help reduce cravings and withdrawal symptoms of alcohol and opioid use disorders, although authors said “the evidence is preliminary, and more research is needed to establish its efficacy and safety.”
Both THC and CBD have also been investigated as possible sleep aids, though results are still preliminary and so far are mixed, with some patients experiencing improved sleep quality while others experience sleep disruptions.
As for treating cancer, the report says that studies have indicated that “cannabinoids can exert antitumor effects directly by inhibiting cell proliferation and inducing apoptosis, or indirectly by inhibiting angiogenesis, invasion, and metastasis.”
“In vivo and in vitro research has demonstrated the efficacy of cannabinoids in modulating tumor growth, although the antitumor effects can vary depending on the type of cancer and the concentration of the drug,” it continues. “For cancer patients, it is crucial to comprehend how cannabinoids control immune system interactions and other biological processes related to carcinogenesis, such as cell cycle progression, proliferation, and cell death. Additional research is necessary for this area.”
As for minor cannabinoids, compounds such as CBG and CBN appear to have antibacterial effects, researchers found. CBN itself also appears to be a mild sedative, which could be relevant for treating sleep disorders.
THC-V, meanwhile, may act as an appetite suppressant and a “potential treatment for diabetes.”
Cannabinoids may also be helpful in treating trauma wounds, authors noted, potentially reducing perceived pain, inflammation and secondary tissue damage.
A new review of the science around the components of marijuana says the “complex interaction between phytocannabinoids and biological systems offers hope for novel treatment approaches,” laying the groundwork for a new era of innovation in cannabis-based medicines.
Among other takeaways, the report, published earlier this month in the International Journal of Molecular Sciences, underscores the potential of whole-plant cannabis medicine—incorporating the variety of cannabinoids, terpenes and other compounds produced by the cannabis plant—rather than simply THC or CBD on their own.
“The plant Cannabis exhibits an effect called the ‘entourage effect’, in which the combined actions of terpenes and phytocannabinoids results in effects that exceed the sum of their separate contributions,” the study says. “This synergy emphasizes how important it is to consider the entire plant when utilizing cannabinoids medicinally as opposed to just concentrating on individual cannabinoids.”
[Using Marijuana Before Working Out Can Enhance Enjoyment And ‘Runner’s High’]()0 seconds of 0 secondsVolume 0% NextStay
Much of the 23-page report—from pharmacy researchers at Ovidus University of Constanta and the University of Medicine, Pharmacy Science and Technology of Târgu Mures, both of which are in Romania—comprises an overview of cannabinoids, including THC and CBD as well as cannabigerol (CBG), cannabichromene (CBC), cannabinol (CBN) and tetrahydrocannabivarin (THC-V)—as well as how those compounds appear to interact with the human body.
While the vast majority of research has studied THC and CBD, the new review notes that the “exploration of novel phytocannabinoids is rapidly evolving, offering exciting prospects for future therapeutic applications.”
“Beyond well-established compounds like THC and CBD, the quest for novel cannabinoids widens the scope of potential treatments,” it says. “Each cannabinoid, with its unique chemical structure, interacts differently with the [endocannabinoid system], suggesting tailored therapeutic effects for specific conditions. This exploration seeks to harness similar benefits while circumventing associated drawbacks.”
Each of the chemical components has specific effects, which the study briefly describes. The broad review, which cites nearly 100 other sources, acknowledges that some effects are bolstered by robust scientific evidence, while others are still being explored.
THC, for example, has demonstrated analgesic effects, authors wrote. “It also possesses antiemetic effects, which make it useful for chemotherapy-induced nausea and vomiting.”
CBD, meanwhile, has demonstrated anti-inflammatory properties and “is said to have analgesic properties and may be effective in pain management.” Some research also shows the cannabinoid may have neuroprotective qualities.
While CBD formulations like the prescription drug Epidiolex can treat rare forms of epilepsy, mixes of CBD and THC may help address spasticity related to multiple sclerosis, the paper says.
Both THC and CBD also have antioxidant effects, it adds, and both appear to be promising tools for a variety of ailments, from pain to neurological disorders and psychiatric conditions.
Further, CBD may help reduce symptoms of anxiety and PTSD, while both THC and CBD may exhibit antidepressant effects. “While some findings suggest that cannabinoids may have mood-stabilizing effects and enhance serotonin signaling, the evidence is inconclusive, and further research is needed,” the study says.
CBD may also help reduce cravings and withdrawal symptoms of alcohol and opioid use disorders, although authors said “the evidence is preliminary, and more research is needed to establish its efficacy and safety.”
Both THC and CBD have also been investigated as possible sleep aids, though results are still preliminary and so far are mixed, with some patients experiencing improved sleep quality while others experience sleep disruptions.
As for treating cancer, the report says that studies have indicated that “cannabinoids can exert antitumor effects directly by inhibiting cell proliferation and inducing apoptosis, or indirectly by inhibiting angiogenesis, invasion, and metastasis.”
“In vivo and in vitro research has demonstrated the efficacy of cannabinoids in modulating tumor growth, although the antitumor effects can vary depending on the type of cancer and the concentration of the drug,” it continues. “For cancer patients, it is crucial to comprehend how cannabinoids control immune system interactions and other biological processes related to carcinogenesis, such as cell cycle progression, proliferation, and cell death. Additional research is necessary for this area.”
As for minor cannabinoids, compounds such as CBG and CBN appear to have antibacterial effects, researchers found. CBN itself also appears to be a mild sedative, which could be relevant for treating sleep disorders.
THC-V, meanwhile, may act as an appetite suppressant and a “potential treatment for diabetes.”
Cannabinoids may also be helpful in treating trauma wounds, authors noted, potentially reducing perceived pain, inflammation and secondary tissue damage.
“At the site of injury, cannabinoids may decrease the release of tissue activators and sensitizers, modulating nerve cells to control tissue destruction and immune cells to prevent the release of proinflammatory substances,” they wrote. “This modulation helps minimize pain and temper post-injury responses associated with inflammatory injury.”
The review also assesses the “challenges and controversies” surrounding research and use of therapeutic cannabinoids, including legal and regulatory obstacles that still vary widely across the globe, a lack of robust standardization of cannabinoid products and the potential for abuse and dependence.
THC, researchers acknowledge, is not only the primary psychoactive compound in cannabis but also the most common cannabinoid associated with problem use. “While the overall risk of addiction to THC is lower compared to substances like opioids, amphetamines, or alcohol,” authors wrote, “it is still a concern, particularly for individuals who use cannabis frequently or in high doses.”
On the other hand, CBD “is not associated with the same potential for abuse or dependence” and “may even have potential therapeutic effects in reducing addiction to other substances, such as opioids, alcohol, or nicotine.”
Social and legal obstacles, the study noted, still make research onerous.
“Despite its potential, legal restrictions and societal stigma surrounding cannabis hinder investment in research and development,” authors of the study wrote. “Complex regulatory frameworks further complicate exploration efforts. Rigorous preclinical and clinical trials are imperative to establish safety and efficacy before therapeutic implementation.”
As cannabinoids and the body’s own endocannabinoid system continue to be better understood, the researchers expect even more “potential in managing various pathological diseases.”
“Phytocannabinoids offer diverse therapeutic applications, ranging from pain management to neurological disorders and inflammatory diseases. Their antimicrobial and anti-inflammatory properties make them valuable candidates for combating antibiotic resistance and modulating inflammatory pathways,” the study concludes. “By leveraging the synergistic effects of combination therapies and targeting multiple disease pathways, phytocannabinoids hold immense potential to revolutionize the future of pharmacotherapy and improve human health outcomes.”
The new research is part of a growing field of investigation into the entourage effect in cannabis as well as in entheogenic plants and fungi. While Western medicine typically seeks to identify and isolate a single active ingredient, the findings underscore the potentially powerful interactions of various chemical components produced by the plant.
Earlier this year, for example, a study looked at the “collaborative interactions” between cannabinoids, terpenes, flavonoids and other molecules in the plant, concluding that a better understanding of the relationships of various chemical components “is crucial for unraveling cannabis’s complete therapeutic potential.”
Other recent research funded by the National Institute on Drug Abuse (NIDA) found that a citrusy-smelling terpene in marijuana, D-limonene, could help ease anxiety and paranoia associated with THC. Researchers similarly said the finding could help unlock the maximum therapeutic benefit of THC.
A separate study last year found that cannabis products with a more diverse array of natural cannabinoids produced stronger psychoactive experiences in adults, which also lasted longer than the high generated by pure THC.
And a 2018 study found that patients suffering from epilepsy experience better health outcomes—with fewer adverse side effects—when they use plant-based CBD extracts compared to “purified” CBD products.
Scientist last year also discovered “previously unidentified cannabis compounds” called flavorants that they believe are responsible for the unique aromas of different varieties of marijuana. Previously, many had thought terpenes alone were responsible for various smells produced by the plant.
Similar phenomena are also beginning to be recorded around psychedelic plants and fungi. In March, for example, researchers published findings showing that use of full-spectrum psychedelic mushroom extract had a more powerful effect than chemically synthesized psilocybin alone. They said the findings imply that mushrooms, like cannabis, demonstrate an entourage effect.
https://www.marijuanamoment.net/interaction-of-marijuana-terpenes-and-cannabinoids-offers-hope-for-novel-treatments-study-says/

Heat waves can be dangerous, but by following soms simple precautions, you can stay cool and healthy. The following is a simple guide which will provide tips on how you can prepare your home, stay hydrated, and recognize the signs of heatstroke and heat exhaustion.
Before the Heat Wave Hits:
• Have a plan: Identify air-conditioned spaces in your community like libraries, malls, or cooling centers. If you rely on medication, ensure you have enough stocked up in case of power outages, and have a thermally regulated container for any medicine which needs to be kept cool. • Prepare your home: Close blinds or curtains during the hottest part of the day. Insulate windows with reflective film if possible. Block out as much direct sunlight as you can and create shade. • Check your appliances: Ensure your air conditioner is functioning properly. If you don't have AC, invest in fans or use traditional hand fans.
Staying Cool During the Heat Wave:
• Hydrate: Drink plenty of fluids throughout the day, even if you don't feel thirsty. Avoid sugary drinks and excessive alcohol, since these can dehydrate you. • Dress for the weather: Wear loose-fitting, lightweight, light-colored clothing made from breathable fabrics like cotton. • Limit outdoor activities: Avoid strenuous exercise or outdoor work during the hottest part of the day (typically between 10 am and 4 pm). • Take cool showers or baths: This is a great way to lower your body temperature quickly. • Spend time in air conditioning: If your home isn't air-conditioned, visit cooling centers or public libraries during the peak heat hours. Alternatively try and stay in shades areas.
Signs of Heat Distress:
It's crucial that you recognize the signs of heat-related illnesses and take immediate action, especially if you cannot avoid the heat.
• Heat cramps: Painful muscle cramps, often in the legs and abdomen. • Heat exhaustion: Heavy sweating, weakness, dizziness, nausea, and vomiting. • Heat stroke: The most serious heat illness. Symptoms include a high body temperature (above 40°C), confusion, disorientation, seizures, and loss of consciousness.
If you experience any of these signs:
• Move to a cool place and remove excess clothing. • Drink plenty of fluids. • Cool down your body with wet cloths or a cool bath. • If symptoms are severe or persist, call an ambulance immediately.
Additional Tips:
• Never leave children or pets unattended in a parked car. • Check on any elderly neighbors and relatives who are more vulnerable to heat. • Limit your use of ovens and stoves, as they can add heat to your home.
By following these tips, you can stay safe and healthy during this heat wave. Remember, staying hydrated and avoiding excessive heat exposure are the most important things you can do. Stay safe and keep enjoying summer drinks such as nimbu paani, rooh afza, jal jeera, lassi, etc.

I went to the dentist last Monday because I had a throbbing toothache (my top right side) since the Wednesday prior. Leading up to the appointment I was taking 800mg of Ibuprofen and 500mg of Acetaminophen every 6 hours to avoid any problems. The need for this was extreme because speaking is important for sales.
Monday comes along and the dentist takes a quick look at my tooth and says it needs to be pulled. I knew the wisdom tooth was the problem (all four of my wisdom teeth had erupted before/during college) because I had cracked it at wrestling practice over a decade ago. The decision to remove one tooth quickly became all four. I called my boss to make sure it was okay that I went through with this, which he gave me the go-ahead.
I returned at 3pm to begin the surgery. They kept me awake for the entire procedure. I was laughing gas (I paid for the laughing gas because it wasn’t covered by insurance😐) and numbing agents. Because of how developed my roots were, the dentist has to put in some work to pull these suckers out. I’m pretty sure I heard him grunt at one point. The surgery took approximately 1 hour in total. At the conclusion of the surgery, I drove myself home with what the doctor sent me off with:

1. A prescription of antibiotics
2. ALOE VERA lol
3. A pat on the back to keep up the advil/tylenol regimen
   I guess I was/am mildly frustrated at the fact that I was sent home so casually. No pain medicine. Barely anything letting me know how tough this recovery process would be at my age.
   The first few hours after were awful. I was still numb. I was getting blood everywhere on the sheets. I kept swallowing blood to the point of nausea. My saving grace was biting down on black tea bags opposed to the gauze. I could not recommend that more. I bit down for about 30 minutes and that stopped the bleeding. The first 2 days I just slept during the day. My boss was gracious enough to give me those days off. Though it was still hard to relax. I’m 30, my girlfriend is 32, our baby girl is 10 months old.
   

During this week of recovery: 1. My girlfriend developed an acute sinus infection 2. I went back to work on Thursday still swollen 3. We brought the baby to the emergency room because she developed a yeast infection
It’s been a hell of a week to say the least. I went to urgent care on Sunday morning because the pain has only seemed to get worse. They gave me a prescription for pain meds. I don’t think I have any dry sockets, but I have developed strep like symptoms. Has anyone experienced something similar so long after the surgery? Im hoping people can offer some comfort that things will be alright.

I have had RLS (since I can remember) at 16, although I remember having sleep problems as a child so it’s quite possible it started much younger.
I’ve managed the condition using marijuana but tried ropinerole about 7 years ago. I came off of that after a few weeks due to the nausea and constant hot flushes.
During a pregnancy almost two years ago the symptoms became severe. I was of course not using marijuana during pregnancy and therefore was sleeping 2-3 hours per night, spending the night crying… then going insane as this progressed for around 8-10 weeks of sleep deprivation. Doctors wouldn’t take me seriously because they didn’t want to medicate me. Finally a sleep doctor prescribed codeine but the dose I required to get rid of my symptoms was too high for him to be comfortable. Then I was put on pramipexole (sifrol), this helped at 0.125 for a while and then needed to be increased to 0.250.
Edited (adding this part): I was iron deficient at this time and received an infusion and have had normal- high levels of iron since. The doctor has checked these levels a few times and is still happy with them, I can’t remember the number but I know it’s above the requirements for someone with RLS. I also had no relief from the infusion.
My symptoms started occurring earlier in the night, slowly moving from 8:30 to 7:30 and then earlier. And now I have RLS in the mornings, with my symptoms start from about 3am and continuing well into the morning, even happening while I am exercising at the gym. I will also have them if I sit or lay down during the day, at work, in lectures, at the movies, etc.
Sadly the pregnancy ended in a loss, not related to the medication or sleep issues, but I continued to take the medication and using medical marijuana and Valium for nights the symptoms were unbearable.
I have now been on pramiexole for about 1.5 years and it is clearly not working. I refuse to increase my dose because of augmentation and we are currently trying to conceive. I also notice a lack of impulse control at higher doses.
My sleep doctor prescribed me Targin to come off of pramipexole for 10 days (cold turkey I might add) and then go back on it to see if it ‘reset’ the medication, but this didn’t work.
But! When I was taking 5mg targin in the morning and 10mg targin at night, I no longer had RLS. It was amazing!
I went back to the doctor and told him that pramipexole isn’t working, I don’t want to increase, my symptoms have augmented severely to the point I have RLS 24/7 and I asked to be put on Targin. (Opiates are safer in pregnancy than dopamine agonists so this was part of my thought process - why keep taking something that doesn’t work that well and isn’t pregnancy safe). He refused as he is worried about dependence and then told me to increase my pramipexole dose instead… he gave me targin for breakthrough symptoms however targin is not effective for this because it takes 2 hours to kick in, and when I have breakthrough symptoms, I need something to work quickly. I tried to increase my pramipexole dose and stopped after two days because my impulse control was horrendous.
Between the last visit and next visit (next week) it has been almost two months. In the meantime, my husband and I are suspecting that pramipexole may be responsible for other psychological symptoms that I am experiencing. I experience an inability to deal with stress and end up with leaden paralysis quite often. I experience many of the symptoms of dopamine agonist withdrawal, no motivation, no interest in activities or hobbies. So my husband suggested I try to halve my dose back to 0.125 to see how I was, and my ability to deal with stress improved but my RLS is so severe that I am struggling to function. I went back to 0.250 and the same depressive symptoms occurred.
Anyway… sorry for the long post but I will be seeing my sleep doctor next week, I’ll be bringing my husband along to advocate for me because it seems my doctor doesn’t take me seriously. We want me to be off of pramipexole. I can’t take gabapentin due to its unsafe nature in pregnancy (but I also don’t even want to take this medication in the first place). For me, the only logical solution is daily opiate therapy. I would rather be dependent on opiates than to suffer the agony that I am in now. But my doctor won’t support this.
Any advice for my appointment or situation? (Absolutely no alternative medicine suggestions please and thank you)
Anyone else feel that dopamine agonists changed their personalities and caused them to be depressed?
Edited: I am located in Australia

I made a post last night about being afraid to go to bed. I ended up falling asleep and woke up to either n* or a panic attack. it always feels the same. I tried to calm down but couldn’t and ran straight to take anti-nausea medicine. it helped but it also could’ve been my anxiety, I have no idea. this puts me in such an uncomfortable position. I hate being scared to sleep. I hate being afraid of being s* 🥺

Hey everyone, about me- I’m a 30 year old male in USA. Always been an athlete but heavy blunt smoker. I’m a picky eater but don’t eat the best foods since Covid era. Quit drinking soda for 10+ years but recently started drinking coke again. As I’ve gotten older, I’m not as active. Just work go home and play Call of duty with friends. I work a commission job that I think is day to day stressful.
About 4 days ago, I was smoking a blunt before bed. All of a sudden I had a crazy heart rate and body got hot, hands and feet sweaty, about 500 different random negative scenarios came flying through my mind and I was freaking the eff out. Never had any anxiety before but I felt like I was having an anxiety attack, tried going inside to shower and was crying for like 2 hours (I think I was frustrated I didn’t know what was going on) I also was super nauseous and I fear of throwing up so it was a wild night. Ended up throwing up middle of night and had another anxiety attack…
Next day I took Dramamine, semi helped but not really, tried carrying on for the next couple of days but I was eating, talking, motivated, energetic, happy… just felt like my life had ended for some reason.
Finally woke up yesterday and was tired of it, went to urgent care, they prescribed my hydroxyzine 25mg and some nausea medicine.
It’s definitely helped but I still have a racing heart beat or an extra hard beat randomly that’ll get the heart rate faster. If there is anyone info or help… I would appreciate it!
I’ve only eaten 2 bowls of ramen and one plate of plain chicken and rice… I’ve lost 10lbs already too… please any help or insight would be nice! I’m tired and I feel bad for my gf also cause she is scared and not sure what to do.

I have a question on whether or not I need to declare basic medicine Paracetamol 500mg Ondansetron (nausea) Azithromycin (diarrhoea) Malarone, Atovaquon + Progualin (malaria)
There isn’t a place on the declaration to declare basic medications, but it does have
“Narcotics, psychotropic substances, precursors, drugs, firearms, air guns, sharp objects, ammunitions, explosives, pornographic objects”
Would I need to tick yes to this?

Hi all,
First of all: My fullest respect to all ER workers and emergency service workers. You lot are amazing.
I do wanna preface this by saying that I am neither. I work in the medical department of a football (soccer) club, so I'm there in the emergency, but also long term after. Hope I'm still good to post here. (the flair Advice would have worked as well tbf)
Needless to say, most things we do are orthopedic issues, traumatic injuries, surgery, general sports medicine etc.., you get the gist. We are sort of the general practitioners for these guys too though. If they have a medical issue of any sort, they'll usually come to us first, so we do have a bit of experience in other fields too. Extreme examples: This season we had a case of myocarditis and a case of sepsis. Sepsis was caught early with no long term consequences, but the guy (only 19) with myocarditis had severe complications. He's had a heart attack, spent a week in a coma and now has a pacemaker. Seeing this young guy struggle to get up from the breakfast table and take the five steps over to the buffet is heartbreaking. And in hindsight, it's probably bothering me more than it should be. Doesn't help that the likely cause is a direct misjudgement on our part, when we cleared him for training too soon after a viral infection.
So I've kinda been carrying this around me for a while and there are a few other private and work related issues that have caused me to be burned out a bit. And as life sometimes does, it just threw me the two most extreme workdays possible in my profession.
To paint the scene: I'm stood on the training pitch just observing. I hear a blood curdling scream from another pitch. I grab my shit and haul ass over there. What meets me there is an open fracture of both tibia and fibula. But not just any open leg fracture, best I can describe it is that his leg was nearly amputated. It was hanging on by a big patch of skin, part of his muscles, like two tendons and miraculously, a handful of blood vessels. People were vomiting and dry heaving at the sight. You could have run an anatomy course there. We put a tournequet on, dance the usual dance of what/how much analgesics and/or anaesthetics to give someone who's clearly lost a lot of blood, decided that this is a case for the air ambulance and ultimately somehow managed to stabilize the leg without cutting off the last blood supply. It was a feat. Surgery (one of many) went well and he's doing well considering the circumstances. I still don't know how this happened btw. We do film every training, but nobody has been brave enough to watch that scene yet. The lad who (of course accidentally) did this to him is still inconsolable.
Next day on the training pitch, I hear a sound anyone in my profession fears. A clash of heads and a good one at that. I turn around to find two people on the floor. One moving and clearly just dazed, the other one fully unconcious and not moving. I grab my shit and haul ass over there again. Upon closer inspection I notice blood running out of one of his ears and his mouth, a clear liquid running out of his nose and a drooping face. Not great. When he came back around he slurred his words, was extremely confused, complained of a bad headache and nausea, hearing and vision loss on one side and then started vomiting. Not forgetting the racoon eyes. Anyways - We got to call the air ambulance again. And if you guessed severe intracranial injuries and a basilar skull fracture, you are absolutely correct. He'll get surgery as soon as the swelling has gone down enough. The really heartbreaking part was when he didn't recognize his mother, who was watching the training and in absolute hysterics, anymore. Again, it was bad luck and nothing else, but the other player that was involved in the head duel is devastated.
And I've come to realise - So am I. It should not affect me so much, but it does. These were two extreme unprecedented days for me and the entire medical team (cue the ER nurses laughing), but everyone else seems to have moved past it. But it's such a different story when they aren't strangers, but you see them every day and they are your friends. Rationally, I know I'm a bit burned out, hence why it affects me so much, which is scary to me.
I love my job and I usually bring 200% of enthusiasm to work every day, so this is truly the first time I ever felt this way. But I know I'm not the only one who's felt like this before. Do you have any advice on how I could get myself up and going again?

It’s starting to work and I’m wow’ed. There’s such an apparent difference in task initiation, I can’t believe it and hope it continues! I don’t write on here much but now I’ve begun to refer to people as “my friends on reddit” and this thread is what helped me pull through here’s a bit of my story:

1. ⁠Female; Been on stims 12 years
2. ⁠Tried Strattera recently, I actually began to see small improvement quickly. BUT, my blood pressure increase was insane. I have heart disease in my family and regularly monitor so after a few days it was a no go. I was also so lethargic.
3. ⁠I’m extremely sensitive to medicine. My doctor suggested one of those test recently so I’ll be following up on that
4. ⁠Started on 100mg felt horrible the first 2 days, thought I might even be pregnant the nausea was so bad.. read alllll the messages here. Someone left a really helpful one about putting the capsule in yogurt, I then found another medical research paper that said it’s true, there is no difference if you do it that way. Knowing that I am sensitive, I thought what if I try half of it in yogurt….
5. ⁠So I have slowly tapered myself up over three weeks to a full 100 milligram, beginning with half a capsule sprinkled in yogurt in the morning (thanks to that girl! 🙌🏻)
6. ⁠I still felt slightly ill nearly all morning, so the past 2 nights I’ve taken it before bedtime, as someone else suggested. This has helped with the tiredness and the remainder of the nausea significantly

I’ll keep you posted, but I just wanted to say thank you to my Reddit friends. I know our doctors are experts, which is why my suggested this one, but only us know our bodies and it is important to remember that perhaps you might need to adjust to allow yours to catch up.
i’m also writing this because I am nearly 40 years old and I read so many people on here talking about their child being on it.
I CANNOT imagine putting a child on this immediately at 100 mg. What they feel is real and can be adjusted. We don’t have to suffer physically bc of ADHD. Whoever said 100 mg needed to be the minimum anyways? Pharma? Glad I tapered up!