Height: 160cm
Weight: 63kg
Age: 24
Sex assigned at birth: Female
Geographic region(s) your ancestors are from: Azerbaijan, central Europe.
Medications: For anxiety: Escitalopram and sometimes Alprazolam ( I always had a comically high tolerance for this). To help with allergy symptoms: OTC: diphenhydramine antihistamine
Simplified Symptoms list:
Mouth burn, brain burning, sight issues with two eyes but not with one. Muscle pain, joint pain. Vertigo. My blood pressure dropped to 105 and gets to 90 when I move a lot. My pulse went up to 75-80. Usual body temperature at 35. Need a lot of sleep. Front change makes pain worse ( can't move. I would burn in the building) Taking actice charcoal is good for symptoms but I can feel it go through my intestines.
Health background :
I have always been an anxious kid, so that might worsened many problems I had. I got Escitalopram three years ago. My anxiety is better now. Sometimes I still take Alprazolam when shit hits the fan or if a symptom could be anxiety induced. I always had a very high intolerance for Alprazolam, so it just takes the edge off.
When I was a kid I had a problem with breathing through my nose, but it was said to be probably because of my adenoid. When I was nine, my adenoid was removed. I was sick a lot and my nose bled a lot. After the surgery, the problems stopped. And never got a fever after that.
Background of Symptoms -
Ruled out: Hashimoto, Thyroid issues, blood clot issue. Depression. Mcas. Mcas testing: I had a leukocita mediator production and cytokin test and it was negative. Western blotting was also negative. Anemia perniciosa, imunoblot, intrinsic factor, negative. ASCA IgA ELISA higher (norm: <20 value: 24) ASCA IgG ELISA high (norm <20, value: 84) C-KIT D816V mutation negative.
The mouth burning started when I was little. Hazelnuts, walnuts, banana, peach, pineapple, tomato, toothepaste. It felt like nettle and the mosqito bites that I am also allergic to.
Around when I was twelve, I got very strong stomach aches from time to time, and eating also became a chore. Digesting started tohurt. Couldn’t drink carbonated drinks. I mainly drank water from then on, or tea. Didn't matter what I did, my tongue has been white since then and I had a bad breath too. I didn’t develop an ED, I just felt less and less until I either cried or felt nothing. I became very introverted and preferred not to be around people. My memory became worse and studying got difficult. My grades got worse, but I just spent more time studying. I became more and more tired, although I slept more and more. Even if I did many sports, I still had a very bad stamina.
Before high school, I got pneumonia. I had a low fever for one day. I felt like I had liquid in my lungs for two weeks, but other than that, I had no problem. ( I got medicine for pneumonia.) I still don’t have a good function of my lungs which make me weak at keeping a normal tone at all times. Singing is impossible. I can’t control the amount of air out of my throat. When I eat ice cream, I cough up mucus afterwards always.
I got to high school, and my memory got worse. I lost months, had no idea why I am no longer friends with some people, and what happened. I was a great note-taker tho and religiously never missed school. My grades got worse as highschool went on. My anxiety was through the roof too. My parents noticed nothing because I had little to no relationship with them. My body hurt, eating hurt, my head hurt. I was either crying or felt nothing. I wanted to die so bad. The only thing that kept me alive was an invisible force tying my hand. At the end of high school, I realized I couldn’t die. I won’t die. In the meantime, my body temperature went from 36 to 35. I changed many thermometer, but it's the same.
At the beginning of university, I got glasses. I had a very low level of astigmatism in one eye. Separately, I can see well. Together not so much. I always have the problem that I can’t see the text, but I can read it. I also realized that I didn’t see in 3D without glasses. Guess that is why I am good at drawing.
I went through university counting every step I took from my bed, to back to my bad after a day. By the third year of university, I got an allergic reaction to something (that looked like Crohn's symptoms, red nodules) and got antihistamine medicine. On antihistamine, I realized that I couldn’t breathe through my nose right until then. We never figured out the problem, but I was on antihistamine for a year. Then I went to the doctor. I got an allergy test and tested positive for tomato, milk protein, egg protein, capsicum, wasp sting, Camille, nettle, and hazelnuts. It wasn’t the shock kind of allergy, just allergy. The doctor said nothing, but to leave those foods. Never saw her again. I stopped these foods, and after leaving milk and eggs, I went through a personality change. I had feelings for the first time in a long time. Until then I just mimicked everyone's emotions, but then I got my own ones. I liked different clothes, different songs, different everything. I became more social, but although I felt like waking up from a ten-year-long coma, my parents didn’t understand what changed. I had bigger problems tho. It felt like I lost ten years of my life. I had to relearn how to cook, how to exist, how to deal with emotional issues. I had lost so many memories from the last ten years that I couldn’t access. When I eat eggs, I revert to the previous mindset and feel like my past self. I have questions prepared for those times and get answers to important questions, like “How do you cook?”. Usually getting better from eggs in two months, so I only eat eggs by accident. It is usually breathing problems and muscle weakness. The antihistamine I took was loratadine, but it became useless and my breathing got difficult again. Milk usually causes rotten feeling in my sotmach and I feel numb emotionally for a few days.
While I got my allergy test, I also tested positive for iron deficiency, and then blood in my stool, although I have never seen blood. I got checked out by a gastroenterologist intimately. I had nothing that would cause my reflux, but he found an inflammation in my intestines. So I got local immunosuppressants (budesonide). That didn’t work. So, I went on steroids and then on immunosuppressants (azathioprine). It caused some problems.
I got my period at 14 and it never got periodical. I missed months, half a years usually but the ob-gyns never found anything. After a year, on azathioprine, my period stopped. I had PCOS and Insulin resistance. I am on a diet for a year now. It didn’t change anything. I felt sick the moment I got on azathioprine, but my doctor made me to be on it for one and half a year. I couldn’t eat and I slept 14 hours on average. Sleeping through days also wasn’t rare. I missed so many deadlines in university. My joints hurt so much, walking with a cane was not rare. My blood pressure got lower (around 105, if I move lot, goes down to 90) and my pulse went from 60 to 75-80. I feel vertigo a lot. At the same time, the food problems never stopped. Food still burned. My tongue was still white unless my stomach issues felt better. My headache never went away, but now it feels like it's burning like my mouth.
I found antihistamine diet, and I don't have stomach aches, although my doctor says it is probably a placebo. I stopped the immunosuppressant, 3 months ago and I very rarely have stomach problems. I try to buy natural toothpaste and it seems to be working altough it is very difficult. My tongue is rarely white. I started taking diphenhydramine antihistamine. Breathing is way better. The brain burning got better for a while, but it’s worse again. I feel like this antihistamine is loosing its strength too.
Family history - Mom: hashimoto, breast cancer ( not genetic), sister: Hashimoto, endometriosis. Maternal grandma: depression. Paternal grandma: underdeveloped uterus. Dad: two strokes.
**Other information-**Never took drugs. I never smoked, because any smoke makes me cough and unable to breathe. Also if someone cooks with some spices. I always got nauseus from alcohol, so I only drank like 2-3 times, then gave up. I use soap bars for everything, so luiqid soap is not the problem. I only have glass food containers. I don't take nicotine in any shape or form. I don't really consume coffein. I started eating cacao, so it might help with the stem cells. The proteins I can eat are: rice, wheats, oat, hemp. I can't consume omega 6 oils. I have a high fiber diet and drink 2 liters of water that I put salt in and taurin. I take vitamin C, magnesium, vitamin D, b16, b6, copper. I try to build up my stamina step by step, although it's shitty. I have a hign endurance, but my brain switches off more and more. I am on a n antihistamine diet.

cw depression and suicide attempt, but not detailed
Edit: thorough MCas testing and outcome added.
This is going to be long, but I lived it trhough, so...
Earlier medical background:
I have always been an anxious kid, so that might worsened many problems I had. I got Escitalopram three years ago. My anxiety is better now. Sometimes I still take Alprazolam when shit hits the fan or if a symptom could be anxiety induced. I always had a very high intolerance for Alprazolam, so it just takes the edge off.
When I was a kid I had a problem with breathing through my nose, but it was said to be probably because of my adenoid. When I was nine, my adenoid was removed. I was sick a lot and my nose bled a lot. After the surgery, the problems stopped. And never got a fever after that.
I never smoked, because any smoke makes me cough and unable to breathe. Also if someone cooks with some spices. I always got nauseus from alcohol, so I only drank like 2-3 times, then gave up. I use soap bars for everything, so luiqid soap is not the problem. I only have glass food containers. I don't take nicotine in any shape or form. I don't really consume coffein. I started eating cacao, so it might help with the stem cells.
Medical history:
Since I was little, many food felt like it is burning my mouth. Like it’s eating it away. The main problem was pepper because that bothered the adults the most. It hurt when something had haselnuts, walnuts, banana, pineapple, peach, Tomato, capsicum in it and toothpaste. Toothpaste is the worst. Chili is a different kind of pain. I showed allergy to nettle and mosquito bites since I was little. The pain in my mouth and what these allergies caused were very similar.
Around when I was twelve, I got very strong stomach aches from time to time, and eating also became a chore. Digesting hurt. I couldn’t drink carbonated drinks. I mainly drank water from then on, or tea. Didn't matter what I did, my tongue has been white since then and I had a bad breath too. I didn’t develop an ED, I just felt less and less until I either cried or felt nothing. I became very introverted and preferred not to be around people. My memory became worse and studying got difficult. My grades got worse, but I just spent more time studying. I became more and more tired, although I slept more and more. Even if I did many sports, I still had a very bad physique.
Before high school, I got pneumonia. I had a low fever for one day. I felt like I had liquid in my lungs for two weeks, but other than that, I had no problem. ( I got medicine for pneumonia.) I still don’t have a good function of my lungs which make me weak at keeping a normal tone at all times. Singing is impossible. I can’t control the amount of air out of my throat. When I eat ice cream, I cough up mucus afterwards always.
I got to high school, and my memory got worse. I lost months, had no idea why I am no longer friends with some people, and what happened. I was a great note-taker tho and religiously never missed school. My grades got worse as highschool went on. My anxiety was through the roof too. My parents noticed nothing because I had little to no relationship with them. My body hurt, eating hurt, my head hurt. I was either crying or felt nothing. I wanted to die so bad. The only thing that kept me alive was an invisible force tying my hand. At the end of high school, I realized I couldn’t die. I won’t die. In the meantime, my body temperature went from 36 to 35. I changed many thermometer, but it's the same.
At the beginning of university, I got glasses. I had a very low level of astigmatism in one eye. Separately, I can see well. Together not so much. I always have the problem that I can’t see the text, but I can read it. I also realized that I didn’t see in 3D without glasses. Guess that is why I am good at drawing.
I went through university counting every step I took from my bed, to back to my bad after a day. By the third year of university, I got an allergic reaction to something (that looked like Crohn's symptoms, red nodules) and got antihistamine medicine. On antihistamine, I realized that I couldn’t breathe through my nose right until then. We never figured out the problem, but I was on antihistamine for a year. Then I went to the doctor. I got an allergy test and tested positive for tomato, milk protein, egg protein, capsicum, wasp sting, Camille, nettle, and hazelnuts. It wasn’t the shock kind of allergy, just allergy. The doctor said nothing, but to leave those foods. Never saw her again. I stopped these foods, and after leaving milk and eggs, I went through a personality change. I had feelings for the first time in a long time. Until then I just mimicked everyone's emotions, but then I got my own ones. I liked different clothes, different songs, different everything. I became more social, but although I felt like waking up from a ten-year-long coma, my parents didn’t understand what changed. I had bigger problems tho. It felt like I lost ten years of my life. I had to relearn how to cook, how to exist, how to deal with emotional issues. I had lost so many memories from the last ten years that I couldn’t access. When I eat eggs, I revert to the previous mindset and feel like my past self. I have questions prepared for those times and get answers to important questions, like “How do you cook?”. Usually getting better from eggs in two months, so I only eat eggs by accident. It is usually breathing problems and muscle weakness. The antihistamine I took was loratadine, but it became useless and my breathing got difficult again. Milk usually causes rotten feeling in my sotmach and I feel numb emotionally for a few days.
While I got my allergy test, I also tested positive for iron deficiency, and then blood in my stool, although I have never seen blood. I got checked out by a gastroenterologist intimately. I had nothing that would cause my reflux, but he found an inflammation in my intestines. So I got local immunosuppressants (budesonide). That didn’t work. So, I went on steroids and then on immunosuppressants (azathioprine). It caused some problems.
I got my period at 14 and it never got periodical. I missed months, half a years usually but the ob-gyns never found anything. After a year, on azathioprine, my period stopped. I had PCOS and Insulin resistance. I am on a diet for a year now. It didn’t change anything. I felt sick the moment I got on azathioprine, but my doctor made me to be on it for one and half a year. I couldn’t eat and I slept 14 hours on average. Sleeping through days also wasn’t rare. I missed so many deadlines in university. My joints hurt so much, walking with a cane was not rare. My blood pressure got lower (around 105, if I move lot, goes down to 90) and my pulse went from 60 to 75-80. I feel vertigo a lot. At the same time, the food problems never stopped. Food still burned. My tongue was still white unless my stomach issues felt better. My headache never went away, but now it feels like it's burning like my mouth.
I was tested for Mcas, but it was negative. My blood was checked if I have a higher chance for blood clots, it was negative. For MCas, I had a leukocita mediator production and cytokin test and it was negative. Western blotting was also negative. Anemia perniciosa, imunoblot, intrinsic factor, negative. ASCA IgA ELISA higher (norm: <20 value: 24) ASCA IgG ELISA high (norm <20, value: 84) C-KIT D816V mutation negative.
I found antihistamine diet, and I don't have stomach aches, although my doctor says it is probably a placebo. I stopped the immunosuppressant, 3 months ago and I very rarely have stomach problems. I try to buy natural toothpaste and it seems to be working altough it is very difficult. My tongue is rarely white. I started taking diphenhydramine antihistamine. Breathing is way better. The brain burning got better for a while, but it’s worse again. I feel like this antihistamine is loosing its strength too.
I am writing, because although my stomach is better, my joints sometimes feel like there is not enough liquid for them and they hurt. Using the stairs upwards is a big problem. Sometimes I need to use a cane just for walking. When the front changes, I can’t move, because then I would want to cry from the pain. Sometimes random food also causes me to be in bad for a day or two and not being able to move. My brain feels like it’s on fire and I just want to scream and hit it into a wall.

28F, 60kg, ulcerative colitis controlled by azathioprine and Stelara.
A very small thing, but I went for a covid jab the other day at the pharmacy. The pharmacist didn't use an alcohol swab to clean my arm and just went straight in with the needle. I give myself Stelara injections at home and was always taught to clean the area with alcohol and let it dry prior to giving the injection. Is this normal?

18f might sound silly but i’m new to this. recently got disgnosed with autoimmune hepatitis and currently on my first round of steroids & azathioprine, luckily no scarring just inflammation. what does this mean for me ? can i never drink alcohol again ? can i not party like the rest of the people my age ? there isn’t much information on google about this and i know of course as of right now i shouldn’t be drinking, i just mean in the foreseeable future

25 F, 5'10 173 lbs
no smoking/drugs/alcohol
medical history: rheumatoid arthritis, autoimmune hepatitis?
meds: prior to AIH diagnosis: sulfasalazine and tocilizumab. now: budesonide and azathioprine
​
i was diagnosed with autoimmune hepatitis in december 2023 after a liver biopsy. prior to that, i had been taking sulfasalazine for RA for about 2.5 years (liver enzymes first became elevated 2 years after starting). i stopped it for ~2-3 weeks when we were assessing for drug induced liver injury but my LFTs continued to rise, so we restarted it and got the biopsy. i was started on 9mg budesonide and my enzymes came down a little, but not as much as the hepatologist wanted to see. after 4 weeks of steroids, he told me to stop the sulfasalazine, we added azathioprine, and continued the budesonide. after being on 50mg AZA and off SSZ for 3 weeks, my enzymes have almost completely normalized. i'm wondering if it's possible that sulfasalazine was the culprit all along and i don't actually have autoimmune hepatitis? everything i find online says that liver injury caused by sulfasalazine usually happens right after you start it, but 3 weeks of azathioprine isn't enough to cause that big of a change right?
biopsy results: "hepatic parenchyma with moderate portal and lobular inflammation, interface hepatitis, focal hepatocyte dropout <5%, and scattered acidophil bodies."
comment: "interface hepatitis composed predominantly of lymphocytes. hepatocyte droupout is present involving <5% of parenchyma and associated with Kupffer cell aggregates. overall, findings are compatible with autoimmune hepatitis in appropriate clinical context. note is made of patient's positive ANA and elevated IgG"

I am 25 years old and have been diagnosed in 2018 and been living with this condition since then. I am a smoker (Cigarettes and pot), eat junk food and consume alcohol too. I had the worst relapse of my disease recently and was admitted in a hospital to get my condition under control. I am doing better now thanks to doctors and my parents and I have decided not to smoke ever again. Lost about 15 Kgs in 6 months and that is making me very anxious.
Have been on and off steroids, tried adalimumab and infliximab and both worked for me. The only problem I had was smoking addiction which worsened my condition. I haven’t been smoking or drinking for more than a month now and right now, I take azathioprine which seems to work for me. Appetite has increased and stools have become normal too.
Please share what helped you the most when you thought everything is going downwards?

I've given up alcohol, smoking, I'm eating a low residue diet, I go for regular walks, I get plenty of rest and I try to avoid stress.
I've had two resections; one in 2011 and the other in 2018 which has affected my BMs, I'm being treated with colestyramine, 150mg of azathioprine daily and adalimumab injections every two weeks.
BUT
I still feel like I'm flaring; digestion hurts and I feel wiped out all the time.
Fuck this disease, I just read that life expectancy is like 75 years but sometimes it feels like I don't actually have that long left
Just a rant

I was diagnosed about a year ago with Behcets after my rheumatologist finally sent off for genetics and I came back positive for HLA B51 gene and it matched up with my symptoms.
I’ve tried colchicine, azathioprine, stopped taking everything for a while (GI issues with colchicine and elevated liver levels/bruising/blood clot with azathioprine) I’ve only been taking daily prednisone, Gabapentin, and have just started back on hydroxychloroquine for joint pain.
My liver has been going through random flares of pain. I have already had my gallbladder removed so now I know it’s my liver. I’ve never been much of a alcohol drinker.
So I’ve had two abnormal liver tests and I just had my third lab, I’m feeling worried.
On top of that I’ve had significant neuro issues and I’ve only had a “runaround” from my specialists that claim that they know about Behcets but I know that they only know OF Behcets, which is totally different.
My eyes have had such significant pressure in them, my neck pain is significant, tinnitus, I literally had my ENT ask me if there was something wrong with my brain because of how badly I failed his balance/hearing tests. He said that my brain doesn’t communicate correctly with my eyes and ears but I should speak to neuro, which I have 😭 I feel so defeated. He is referring me to physical therapy for cervical neck stretches to hopefully help with my nerve issues. I’ve had an entire year of quarterly MRI’s to rule out MS as well but I have had stable lesions (11 lesions). I have major POTS flareups but have passed two tilt-table tests and have been seen by a Dysautonomia Specialist which confirmed that I do not have Dysautonomia.
I’m in North Alabama, limited income because I can’t work (I work freelance when I can) but I can barely deal with scrolling screens, things in front of my face moving when I’m focusing on things (windshield wipers), light sensitivity.
I feel like giving up a lot honestly, my husband just “keeps swimming” because that’s his only option and it sucks. We have to young kids and life gets tough. Especially when I get dizzy or have a massive migraine and can’t play with them.
I guess I’m looking for any advice with similar symptoms? I’m tired of being my own doctor or and advocating for myself
Thanks in advance

Diagnosed with SLE 13 years ago. Main issues are joint pain (worst in hands), fatigue, severe Raynaud's, and bloodwork markers, of course.
Taking Plaquenil for 13 years, Naproxen for 13 years, amlodipine (for bad Raynaud's) for 4 years. Starting azathioprine (Imuran) today.
I am hoping to hear from fellow SLE folks who are taking azathioprine/Imuran. What has been your experience? I know that it is totally individual-dependent, but fellow SLEers know how important it is to gather info from our community!
What have been the main side effects? Has there been a noticeable impact on your immune system in terms of healing/recovering from infection/injury? Did you completely stop drinking alcohol?
Thank you so much for your help and feedback!

I’ve been on azathioprine (100mg) for around 9 months and it’s been going great!
I have fallen into a flare in the past week, I’ve had awful tummy gurgles and that bubbly feeling and one bloody stool plus some other not great ones. No idea what could have triggered it apart from the fact I’ve been relatively relaxed with my diet (tho I am still predominately dairy and gluten free, no alcohol and no caffeine) and I’m quite stressed with lots of uni work and my cat also was just put down. I’m now watching my diet so hopefully the aza can take back control and am going to try and meet my GI to get some uceris foam/ budesonide foam. I feel a bit helpless though, I don’t want to up my dose of immunosuppressants and I don’t want to change them because I was actually getting along with them ok.
Has anyone had any success getting out of a flare like this and continuing on the same meds? Success stories and advice needed! I feel a bit hopeless😕

What is acute pancreatitis?
Acute pancreatitis is an inflammation of pancreas which leads to all the symptoms of the disease.
What are the causes of Acute pancreatitis?
Main causes of acute pancreatitis are gallstones, alcohol, drugs (like furosemide, azathioprine, steroids, and others) and hypertriglyceridemia and hypercalcemia.
What are the symptoms of the disease?
The main symptoms are severe pain in the upper abdomen which can radiate to back. Associated with vomiting and respiratory difficulty. If the disease is severe there may be fever, decreased urine output or bleeding from the GI Tract.
What is the treatment for pancreatitis in Delhi?
The treatment of the disease can be divided into two or three phases
Ist phase is during the first week of the disease: It is the critical care phase in which ICU care is required for the severe cases. Patients may require respiratory support or may even require dialysis in severe cases. This is the time when most of the mortality occurs in the cases of acute pancreatitis.
Pancreatitis treatment in Delhi requires a good ICU care in the initial intensive phase.
2nd phase is in the week 2-3. This is the time when the infective complications increase be it local infections in the surrounding necrosis or respiratory ones. Patient should be fed by mouth as most of the complications are due to bacterial translocation through the intestine. Feeding helps prevent bacterial growth and translocation. In case patient is not able to take orally an enteral feeding tube may be placed for enteral feeding. Antibiotics are given according to the situation.
If the patients get fever and CT documents infected necrosis drainage of the infected collection is required. It is usually done by putting CT/ Ultrasound guided drainage catheter into the collection. Multiple catheters may be required, and frequent upgradation may be needed. Majority of the patients would settle with this management. A few patients would require surgery.
Pancreatitis treatment through surgery in Delhi:
These few patients may require surgery which is pancreatic necrosectomy. It can be done open through minimal invasive means of Laparoscopy
3rd phase is after 4 weeks. This is the phase for managing the late complications like pseudocyst or pancreatic fistulae. This can be done with endoscopic interventions or surgery
To sum up Acute Pancreatitis can be a severe disease which can sometimes become life threatening also. Pancreatitis treatment in Delhi requires a good critical care and may require surgery.
TAGS- Pancreatic Surgery in Delhi, Pancreatic Cancer Treatment in Delhi

I have a scope scheduled this afternoon in about 12ish hours, and I’m wondering if the rest of the afternoon/evening will be enough for me to rest and recuperate to be able to go to work tomorrow. I work retail, so I’m on my feet and moving around for 5+ hours a day. I’ve already been away from work for the past 3 weeks, dealing with the most painful flair I’ve ever had. My first day back was Monday, and I felt okay, just a little bit floaty—almost like a light version of how I feel when I drink alcohol (currently taking prednisone, azathioprine and dicyclomine)
My last scope was 8 years ago when I was first diagnosed, so I don’t really remember what the aftermath was like. I had also just quit the job that I had at the time because my health was (obviously) rapidly declining, so I didn’t really have to think about being a functioning member of society. I know, ultimately, it’s up to me and my body, but I just wanted to know if others feel like they bounce back quickly, or if I should contact my manager and give them a heads up in case they need to schedule someone else

Hello friends, First posteCrohn’s patient/anxiety sufferer here.
I was diagnosed age 14 (now 20) after a period of extreme illness. No appetite, huge weight loss, excruciating pain, you know the drill. Steroid treatment, then azathioprine and infliximab (remicade) did me good for 5 years or so. Colonoscopy in 2019 showed deep remission, so off the remicade I came on the advice of the doc. Six months later, symptoms were pretty unmanageable again, so I was placed on humira, just over a year ago. Admittedly looked after myself pretty badly first year of uni. Very poor diet, alcohol/marijuana/cigarette consumption. My anxiety developed more strongly around this time also. Neglected taking my medication on time, missed a dose or two, carried on as normal. I’ve been experiencing constipation, tenesmus, and some rectal bleeding when straining (maybe once a month on the bleeding) for the last 6 months or so. Also noticed what feels like some internal piles prolapsing, but not too sure. Not typical symptoms for me. Also had some pretty bad abdominal pain and vomiting for a 48 hour period about 1 month ago now. Latest CRP test showed a raised inflammation count, which concerned me given that I don’t really feel like I’m in a flare. I’ve got a routine colonoscopy tomorrow (was scheduled anyway) and anxiety is convincing me they’ll find something other than Crohn’s. I’ve never spoken to anyone else with my condition, and I wanted to see if any of this would seem abnormal or a cause for concern for you.
Many thanks.

Physics

Frontiers of Physics
Title: Demonstration and operation of quantum harmonic oscillators in an AlGaAs−GaAs heterostructure Author: Guangqiang Mei, Pengfei Suo, Li Mao, Min Feng, Limin Cao Volume: Frontiers of Physics , 2023, 18(1): 13310. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1225-7 DOI: https://doi.org/10.1007/s11467-022-1225-7
Title: Topological hinge modes in Dirac semimetals Author: Xu-Tao Zeng, Ziyu Chen, Cong Chen, Bin-Bin Liu, Xian-Lei Sheng, Shengyuan A. Yang Volume: Frontiers of Physics , 2023, 18(1): 13308. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1221-y DOI: https://doi.org/10.1007/s11467-022-1221-y
Title: Two dimensional GeO2/MoSi2N4 van der Waals heterostructures with robust type-II band alignment Author: Xueping Li, Peize Yuan, Lin Li, Ting Liu, Chenhai Shen, Yurong Jiang, Xiaohui Song, Congxin Xia Volume: Frontiers of Physics , 2023, 18(1): 13305. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1216-8 DOI: https://doi.org/10.1007/s11467-022-1216-8
Title: Electronic properties of monolayer copper selenide with one-dimensional moiré patterns Author: Gefei Niu, Jianchen Lu, Jianqun Geng, Shicheng Li, Hui Zhang, Wei Xiong, Zilin Ruan, Yong Zhang, Boyu Fu, Lei Gao, Jinming Cai Volume: Frontiers of Physics , 2023, 18(1): 13303. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1211-0 DOI: https://doi.org/10.1007/s11467-022-1211-0
Title: A multi-band atomic candle with microwave-dressed Rydberg atoms Author: Yafen Cai, Shuai Shi, Yijia Zhou, Jianhao Yu, Yali Tian, Yitong Li, Kuan Zhang, Chenhao Du, Weibin Li, Lin Li Volume: Frontiers of Physics , 2023, 18(1): 12302. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1218-6 DOI: https://doi.org/10.1007/s11467-022-1218-6
Title: A giant atom with modulated transition frequency Author: Lei Du, Yan Zhang, Yong Li Volume: Frontiers of Physics , 2023, 18(1): 12301. URL: https://journal.hep.com.cn/fop/EN/10.1007/s11467-022-1215-9 DOI: https://doi.org/10.1007/s11467-022-1215-9

Material Science

Frontiers of Materials Science
Title: Regulation of cell morphology and viability using anodic aluminum oxide with custom-tailored structural parameters Author: Zhiying ZHANG, Ting LIU, Juan LI, Yiyan GUO, Ruiqing LIANG, Jiangbo LU, Runguang SUN, Jun DONG Volume: Frontiers of Materials Science , 2022, 16(4): 220622. URL: https://journal.hep.com.cn/foms/EN/10.1007/s11706-022-0622-8 DOI: https://doi.org/10.1007/s11706-022-0622-8
Nano Research
Title: In situ TEM visualization of Ag catalysis in Li-O2 nanobatteries Author: Yixuan Wen, Shuaijun Ding, Chongchong Ma, Peng Jia, Wei Tu, Yunna Guo, Shuang Guo, Wei Zhou, Xiaoqian Zhang, Jianyu Huang, Liqiang Zhang, Tongde Shen, Yuqing Qiao Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5359-z DOI: 10.1007/s12274-022-5359-z
Title: Near-Infrared Light-Driven Multifunctional Metal ion (Cu2+)-Loaded Polydopamine Nanomotors for Therapeutic Angiogenesis in Critical Limb Ischemia Author: Liang Gui, Juju Huang, Yi Xing, Yongjun Li, Junjie Zou, Yingwei Zhu, Xiao Liang, Xiwei Zhang, Qiang Xu, Xin Du Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5356-2 DOI: 10.1007/s12274-022-5356-2
Title: Targeted regulation of neuroinflammation via nanobiosignaler for repairing the central nerve system injuries Author: Xiaoru Sun, Huitong Ruan, Qidong Liu, Silu Cao, Qi Jing, Yaru Xu, Lize Xiong, Wenguo Cui, Cheng Li Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5143-3 DOI: 10.1007/s12274-022-5143-3
Title: Integrating molybdenum sulfide selenide-based cathode with C–O–Mo heterointerface design and atomic engineering for superior aqueous Zn-ion batteries Author: Hong Li, Biao Chen, Runhua Gao, Fugui Xu, Xinzhu Wen, Xiongwei Zhong, Chuang Li, Zhihong Piao, Nantao Hu, Xiao Xiao, Feng Shao, Guangmin Zhou, Jinlong Yang Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5108-6 DOI: 10.1007/s12274-022-5108-6
Title: Ionic liquid passivated black phosphorus for stabilized compliant electronics Author: Ravindra Mehta, Misook Min, Ridwan F. Hossain, Gustavo A. Saenz, Gerardo Gamboa, Anupama B. Kaul Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5360-9 DOI: 10.1007/s12274-022-5360-9
Title: A STIR nucleic acid drug delivery system for stirring phenotypic switch of microglia in Parkinson’s disease treatments Author: Yanyue Wu, Wenli Wang, Xinyu Qiu, Zhiguo Lu, Weihong Ji, Jie Shen, Huan Peng, Ruichen Zhao, Jingwen Wang, Tianlu Zhang, Jun Yang, Xin Zhang Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5353-5 DOI: 10.1007/s12274-022-5353-5
Title: Strong In-Plane Optical Anisotropy in 2D van der Waals Antiferromagnet VOCl Author: Tianle Zhang, Jiantao Du, Wenjun Wang, Keming Wu, Shuai Yue, Xinfeng Liu, Wanfu Shen, Chunguang Hu, Minghui Wu, Zhe Qu, Shengxue Yang, Chengbao Jiang Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5358-0 DOI: 10.1007/s12274-022-5358-0
Title: Ultrasensitive and point-of-care detection of plasma phosphorylated tau in Alzheimer’s disease using colorimetric and surface-enhanced Raman scattering dual-readout lateral flow assays Author: Liding Zhang, Ying Su, Xiaohan Liang, Kai Cao, Qingming Luo, Haiming Luo Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5354-4 DOI: 10.1007/s12274-022-5354-4
Title: Diffusion dynamics and characterization of attogram masses in optically trapped single nanoparticles using laser-induced plasma imaging Author: Pablo Purohit, Francisco J. Fortes, Javier Laserna Volume: Nano Research URL: https://www.sciopen.com/article/10.1007/s12274-022-5355-3 DOI: 10.1007/s12274-022-5355-3

Medicine

Frontiers of Medicine
Title: Chinese expert consensus on oral drugs for the treatment of mature B-cell lymphomas (2020 edition) Author: Suning Chen, Weili Zhao, Jianyong Li, Depei Wu, on behalf of Lymphoid Disease Group, Chinese Society of Hematology, Chinese Medical Association Volume: Frontiers of Medicine , 2022, 16(5): 815-826. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0891-0 DOI: https://doi.org/10.1007/s11684-021-0891-0
Title: Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in five Chinese families Author: Rongrong Wang, Liwei Sun, Xiaerbati Habulieti, Jiawei Liu, Kexin Guo, Xueting Yang, Donglai Ma, Xue Zhang Volume: Frontiers of Medicine , 2022, 16(5): 808-814. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0878-x DOI: https://doi.org/10.1007/s11684-021-0878-x
Title: Mycophenolate mofetil or tacrolimus compared with azathioprine in long-term maintenance treatment for active lupus nephritis Author: Qianying Zhang, Peng Xing, Hong Ren, Xiaonong Chen, Jingyuan Xie, Wen Zhang, Pingyan Shen, Xiao Li, Nan Chen Volume: Frontiers of Medicine , 2022, 16(5): 799-807. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0849-2 DOI: https://doi.org/10.1007/s11684-021-0849-2
Title: Palmitoylation of GNAQ/11 is critical for tumor cell proliferation and survival in GNAQ/11-mutant uveal melanoma Author: Yan Zhang, Baoyuan Zhang, Yongyun Li, Yuting Dai, Jiaoyang Li, Donghe Li, Zhizhou Xia, Jianming Zhang, Ping Liu, Ming Chen, Bo Jiao, Ruibao Ren Volume: Frontiers of Medicine , 2022, 16(5): 784-798. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0911-0 DOI: https://doi.org/10.1007/s11684-021-0911-0
Title: Estimating the number of Chinese cancer patients eligible for and benefit from immune checkpoint inhibitors Author: Kaili Yang, Jiarui Li, Lin Zhao, Zhao Sun, Chunmei Bai Volume: Frontiers of Medicine , 2022, 16(5): 773-783. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0902-1 DOI: https://doi.org/10.1007/s11684-021-0902-1
Title: Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202) Author: Jianhua Shi, Ying Cheng, Qiming Wang, Kai Li, Lin Wu, Baohui Han, Gongyan Chen, Jianxing He, Jie Wang, Haifeng Qin, Xiaoling Li Volume: Frontiers of Medicine , 2022, 16(5): 766-772. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0916-8 DOI: https://doi.org/10.1007/s11684-021-0916-8
Title: Outcomes of patients awaiting lung transplantation after the implementation of donation after brain death at a single Chinese center Author: Yuling Yang, Xinnan Xu, Ming Liu, Yanfeng Zhao, Yongmei Yu, Xiaogang Liu, Chang Chen, Gening Jiang, Wenxin He Volume: Frontiers of Medicine , 2022, 16(5): 760-765. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0899-5 DOI: https://doi.org/10.1007/s11684-021-0899-5
Title: Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects with non-alcoholic fatty liver disease: a translational approach Author: Liang Dai, Jingjuan Xu, Baocheng Liu, Yanqi Dang, Ruirui Wang, Lijie Zhuang, Dong Li, Lulu Jiao, Jianying Wang, Lei Zhang, Linda L.D. Zhong, Wenjun Zhou, Guang Ji Volume: Frontiers of Medicine , 2022, 16(5): 745-759. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0880-3 DOI: https://doi.org/10.1007/s11684-021-0880-3
Title: Clinical efficacy of comprehensive therapy based on traditional Chinese medicine patterns on patients with pneumoconiosis: a pilot double-blind, randomized, and placebo-controlled study Author: Jiansheng Li, Hulei Zhao, Yang Xie, Jieya Li, Qingwei Li, Xuexin Chen, Weiyu Zhang Volume: Frontiers of Medicine , 2022, 16(5): 736-744. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0870-5 DOI: https://doi.org/10.1007/s11684-021-0870-5
Title: Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker and therapeutic target Author: Qinming Zhou, Lu He, Jin Hu, Yining Gao, Dingding Shen, You Ni, Yuening Qin, Huafeng Liang, Jun Liu, Weidong Le, Sheng Chen Volume: Frontiers of Medicine , 2022, 16(5): 723-735. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0905-y DOI: https://doi.org/10.1007/s11684-021-0905-y
Title: New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse wave velocity and albuminuria: a prospective cohort study Author: Jialu Wang, Shanshan Liu, Qiuyu Cao, Shujing Wu, Jingya Niu, Ruizhi Zheng, Lizhan Bie, Zhuojun Xin, Yuanyue Zhu, Shuangyuan Wang, Hong Lin, Tiange Wang, Min Xu, Jieli Lu, Yuhong Chen, Yiping Xu, Weiqing Wang, Guang Ning, Yu Xu, Mian Li, Yufang Bi, Zhiyun Zhao Volume: Frontiers of Medicine , 2022, 16(5): 714-722. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-021-0888-8 DOI: https://doi.org/10.1007/s11684-021-0888-8
Title: Targeting apoptosis to manage acquired resistance to third generation EGFR inhibitors Author: Shi-Yong Sun Volume: Frontiers of Medicine , 2022, 16(5): 701-713. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-022-0951-0 DOI: https://doi.org/10.1007/s11684-022-0951-0
Title: Recent advances in systemic lupus erythematosus and microbiota: from bench to bedside Author: Yijing Zhan, Qianmei Liu, Bo Zhang, Xin Huang, Qianjin Lu Volume: Frontiers of Medicine , 2022, 16(5): 686-700. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-022-0957-7 DOI: https://doi.org/10.1007/s11684-022-0957-7
Title: Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives Author: Yuqiu Han, Lanjuan Li, Baohong Wang Volume: Frontiers of Medicine , 2022, 16(5): 667-685. URL: https://journal.hep.com.cn/fmd/EN/10.1007/s11684-022-0960-z DOI: https://doi.org/10.1007/s11684-022-0960-z
Journal of Translational Neuroscience
Title: Bronchial cyst of the posterior mediastinum misdiagnosed as ganglioneuroma: a case report and literature review Author: Yi Bao, Qiong Liu, Hang Li, Wei Huang, Zhibing Ai Volume: Journal of Translational Neuroscience , 2022, 7(1): 23-26. URL: https://journal.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.005 DOI: https://doi.org/10.3868/j.issn.2096-0689.2022.01.005
Title: Bioinformatics analysis of genes differentially expressed in autism and screening of hub genes in the occurrence and development of autism Author: Manli Li, Xiaoli Ma, Chendi Mai, Zhiru Fan, Yankai Ren Volume: Journal of Translational Neuroscience , 2022, 7(1): 15-22. URL: https://journal.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.004 DOI: https://doi.org/10.3868/j.issn.2096-0689.2022.01.004
Title: Research progress of hsa-miR-495-3p and proteolipid protein 1 involvement in the pathogenesis of schizophrenia Author: Zhilan Yang, Hongying Pan, Lan Jiang, Tiantian Jiang, Jie Wu Volume: Journal of Translational Neuroscience , 2022, 7(1): 11-14. URL: https://journal.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.003 DOI: https://doi.org/10.3868/j.issn.2096-0689.2022.01.003
Title: Research progress on the mechanism of N6-methyladenosine methylation modification and proteolipid protein 1 gene in schizophrenia Author: Zhilan Yang, Hongying Pan, Lan Jiang, Tiankai Jiang, Yinhang Li, Jie Wu Volume: Journal of Translational Neuroscience , 2022, 7(1): 6-10. URL: https://journal.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.002 DOI: https://doi.org/10.3868/j.issn.2096-0689.2022.01.002
Title: Research progress of the synapsin 2 gene polymorphism in the pathogenesis of schizophrenia Author: Zhilan Yang, Hongying Pan, Lan Jiang, Yuhang Liang, Jie Wu Volume: Journal of Translational Neuroscience , 2022, 7(1): 1-5. URL: https://journal.hep.com.cn/jtn/EN/10.3868/j.issn.2096-0689.2022.01.001 DOI: https://doi.org/10.3868/j.issn.2096-0689.2022.01.001
Nano TransMed
Title: Insights into the organic semiconducting photosensitizers for hypoxia-tolerant type I photodynamic therapy Author: Xiaoming Hu, Caijun Zhu, Fengwei Sun, Jin Yang, Zejing Chen, Haiyong Ao, Cao Cui, Zhen Yang, Wei Huang Volume: Nano TransMed URL: https://www.sciopen.com/article/10.26599/NTM.2022.9130010 DOI: 10.26599/NTM.2022.9130010

Engineering

Frontiers in Energy
Title: Erratum to: Enhancing the photoelectrochemical performance of p-silicon through TiO2 coating decorated with mesoporous MoS2 Author: Hongmei WU, Feng LI, Yanqi YUAN, Jing LIU, Liping ZHAO, Peng ZHANG, Lian GAO Volume: Frontiers in Energy , 2022, 16(5): 876-877. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0832-x DOI: https://doi.org/10.1007/s11708-022-0832-x
Title: Optimal design analysis of a tubular heat exchanger network with extended surfaces using multi-objective constructal optimization Author: Hassan HAJABDOLLAHI, Mohammad SHAFIEY DEHAJ, Babak MASOUMPOUR, Mohammad ATAEIZADEH Volume: Frontiers in Energy , 2022, 16(5): 862-875. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0839-3 DOI: https://doi.org/10.1007/s11708-022-0839-3
Title: Ti4O7 supported IrOx for anode reversal tolerance in proton exchange membrane fuel cell Author: Yonghuan LI, Wei SONG, Guang JIANG, Yue YANG, Hongmei YU, Zhigang SHAO, Fangwei DUAN, Yingxuan YANG Volume: Frontiers in Energy , 2022, 16(5): 852-861. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-021-0811-7 DOI: https://doi.org/10.1007/s11708-021-0811-7
Title: Multi-stage ammonia production for sorption selective catalytic reduction of NOx Author: Chen ZHANG, Guoliang AN, Liwei WANG, Shaofei WU Volume: Frontiers in Energy , 2022, 16(5): 840-851. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-021-0797-1 DOI: https://doi.org/10.1007/s11708-021-0797-1
Title: Micro-sized hydrothermal carbon supporting metal oxide nanoparticles as efficient catalyst for mono-dehydration of sugar alcohol Author: Cheng PAN, Chao FAN, Wanqin WANG, Teng LONG, Benhua HUANG, Donghua ZHANG, Peigen SU, Aqun ZHENG, Yang SUN Volume: Frontiers in Energy , 2022, 16(5): 822-839. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-020-0677-0 DOI: https://doi.org/10.1007/s11708-020-0677-0
Title: Influence of Fe on electrocatalytic activity of iron-nitrogen-doped carbon materials toward oxygen reduction reaction Author: Lin LI, Cehuang FU, Shuiyun SHEN, Fangling JIANG, Guanghua WEI, Junliang ZHANG Volume: Frontiers in Energy , 2022, 16(5): 812-821. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-020-0669-0 DOI: https://doi.org/10.1007/s11708-020-0669-0
Title: Review on cryogenic technologies for CO2 removal from natural gas Author: Yujing BI, Yonglin JU Volume: Frontiers in Energy , 2022, 16(5): 793-811. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0821-0 DOI: https://doi.org/10.1007/s11708-022-0821-0
Title: Research progress on hydrate plugging in multiphase mixed rich-liquid transportation pipelines Author: Shuyu SONG, Zhiming LIU, Li ZHOU, Liyan SHANG, Yaxin WANG Volume: Frontiers in Energy , 2022, 16(5): 774-792. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-020-0688-x DOI: https://doi.org/10.1007/s11708-020-0688-x
Title: Mechanism and control factors of hydrate plugging in multiphase liquid-rich pipeline flow systems: A review Author: Shuwei ZHANG, Liyan SHANG, Zhen PAN, Li ZHOU, You GUO Volume: Frontiers in Energy , 2022, 16(5): 747-773. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0830-z DOI: https://doi.org/10.1007/s11708-022-0830-z
Title: Novel strategies to tailor the photocatalytic activity of metal–organic frameworks for hydrogen generation: a mini-review Author: Luis A. ALFONSO-HERRERA, Leticia M. TORRES-MARTINEZ, J. Manuel MORA-HERNANDEZ Volume: Frontiers in Energy , 2022, 16(5): 734-746. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0840-x DOI: https://doi.org/10.1007/s11708-022-0840-x
Title: Ion conduction path in composite solid electrolytes for lithium metal batteries: from polymer rich to ceramic rich Author: Zhouyu ZHANG, Hao CHEN, Zhenglin HU, Shoubin ZHOU, Lan ZHANG, Jiayan LUO Volume: Frontiers in Energy , 2022, 16(5): 706-733. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0833-9 DOI: https://doi.org/10.1007/s11708-022-0833-9
Title: Hollow-fiber gas penetration electrodes efficiently produce renewable synthetic fuels Author: Yanfang SONG, Xiao DONG, Wei CHEN, Wei WEI Volume: Frontiers in Energy , 2022, 16(5): 700-705. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0842-8 DOI: https://doi.org/10.1007/s11708-022-0842-8
Title: Amino acid promoted hydrogen battery system using Mn-pincer complex for reversible CO2 hydrogenation to formic acid Author: Zupeng CHEN, Henrik JUNGE, Matthias BELLER Volume: Frontiers in Energy , 2022, 16(5): 697-699. URL: https://journal.hep.com.cn/fie/EN/10.1007/s11708-022-0843-7 DOI: https://doi.org/10.1007/s11708-022-0843-7
Frontiers of Environmental Science & Engineering
Title: Ozonation of aromatic monomer compounds in water: factors determining reaction outcomes Author: Zhe Wang, Wenjuan Zhang, Zhiwei Wang, Jing Chang Volume: Frontiers of Environmental Science & Engineering , 2023, 17(5): 54. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1654-8 DOI: https://doi.org/10.1007/s11783-023-1654-8
Title: Highly degradable chitosan-montmorillonite (MMT) nanocomposite hydrogel for controlled fertilizer release Author: Zeou Dou, Maria Vitoria Bini Farias, Wensi Chen, Dongjing He, Yuhang Hu, Xing Xie Volume: Frontiers of Environmental Science & Engineering , 2023, 17(5): 53. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1653-9 DOI: https://doi.org/10.1007/s11783-023-1653-9
Title: Penicillin fermentation residue biochar as a high-performance electrode for membrane capacitive deionization Author: Jie Liu, Junjun Ma, Weizhang Zhong, Jianrui Niu, Zaixing Li, Xiaoju Wang, Ge Shen, Chun Liu Volume: Frontiers of Environmental Science & Engineering , 2023, 17(4): 51. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1651-y DOI: https://doi.org/10.1007/s11783-023-1651-y
Title: Higher N2O production in sequencing batch reactors compared to continuous stirred tank reactors: effect of feast-famine cycles Author: Xinjie Yan, Xunyu Shen, Jipeng Wang, Jinlong Zhuang, Yu Wang, Jinchi Yao, Hong Liu, Yongdi Liu, James P. Shapleigh, Wei Li Volume: Frontiers of Environmental Science & Engineering , 2023, 17(4): 50. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1650-z DOI: https://doi.org/10.1007/s11783-023-1650-z
Title: Electrocatalytic biofilm reactor for effective and energy-efficient azo dye degradation: the synergistic effect of MnOx/Ti flow-through anode and biofilm on the cathode Author: Yinghui Mo, Liping Sun, Lu Zhang, Jianxin Li, Jixiang Li, Xiuru Chu, Liang Wang Volume: Frontiers of Environmental Science & Engineering , 2023, 17(4): 49. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1649-5 DOI: https://doi.org/10.1007/s11783-023-1649-5
Title: Untargeted metabolomic analysis of pregnant women exposure to perfluorooctanoic acid at different degrees Author: Kaige Yang, Zhouyi Zhang, Kangdie Hu, Bo Peng, Weiwei Wang, Hong Liang, Chao Yan, Mingyuan Wu, Yan Wang Volume: Frontiers of Environmental Science & Engineering , 2023, 17(3): 28. URL: https://journal.hep.com.cn/fese/EN/10.1007/s11783-023-1628-x DOI: https://doi.org/10.1007/s11783-023-1628-x
Frontiers of Mechanical Engineering
Title: Gear fault diagnosis using gear meshing stiffness identified by gearbox housing vibration signals Author: Xiaoluo YU, Yifan HUANGFU, Yang YANG, Minggang DU, Qingbo HE, Zhike PENG Volume: Frontiers of Mechanical Engineering , 2022, 17(4): 57. URL: https://journal.hep.com.cn/fme/EN/10.1007/s11465-022-0713-3 DOI: https://doi.org/10.1007/s11465-022-0713-3
Title: M-LFM: a multi-level fusion modeling method for shape−performance integrated digital twin of complex structure Author: Xiwang HE, Xiaonan LAI, Liangliang YANG, Fan ZHANG, Dongcai ZHOU, Xueguan SONG, Wei SUN Volume: Frontiers of Mechanical Engineering , 2022, 17(4): 52. URL: https://journal.hep.com.cn/fme/EN/10.1007/s11465-022-0708-0 DOI: https://doi.org/10.1007/s11465-022-0708-0
Title: A novel shape memory alloy actuated soft gripper imitated hand behavior Author: Jie PAN, Jingjun YU, Xu PEI Volume: Frontiers of Mechanical Engineering , 2022, 17(4): 44. URL: https://journal.hep.com.cn/fme/EN/10.1007/s11465-022-0700-8 DOI: https://doi.org/10.1007/s11465-022-0700-8

Humanities and Social Sciences

Frontiers of Law in China
Title: Responsibility Determination: Free Will and Legal Responsibility in the Age of Artificial Intelligence Author: ZHU Zhen Volume: Frontiers of Law in China , 2022, 17(1): 122-139. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0028-9 DOI: https://doi.org/10.3868/s050-011-022-0028-9
Title: Jurisprudential Foundation of the Alogithmic Enforcement and Regulation of Law in an Intelligent Society: Taking the Automated Copyright Infringement Monitoring of the Online Content Sharing Platform as an Example Author: ZHANG Jiyu Volume: Frontiers of Law in China , 2022, 17(1): 104-121. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0027-2 DOI: https://doi.org/10.3868/s050-011-022-0027-2
Title: On the Legal Regulation of Algorithms Author: DING Xiaodong Volume: Frontiers of Law in China , 2022, 17(1): 88-103. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0026-5 DOI: https://doi.org/10.3868/s050-011-022-0026-5
Title: Changes of Legal Scenarios in the Era of Artificial Intelligence Author: QI Yanping Volume: Frontiers of Law in China , 2022, 17(1): 67-87. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0025-8 DOI: https://doi.org/10.3868/s050-011-022-0025-8
Title: The Reshaping Effects and Limitations of the Judicial AI Author: MA Changshan Volume: Frontiers of Law in China , 2022, 17(1): 42-66. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0024-1 DOI: https://doi.org/10.3868/s050-011-022-0024-1
Title: New Challenges Posed by Robots to China's Civil Code in the Age of Artificial Intelligence Author: WANG Liming Volume: Frontiers of Law in China , 2022, 17(1): 33-41. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0023-4 DOI: https://doi.org/10.3868/s050-011-022-0023-4
Title: Constructing Legal Order in an Intelligent Society Author: ZHANG Wenxian Volume: Frontiers of Law in China , 2022, 17(1): 1-32. URL: https://journal.hep.com.cn/flc/EN/10.3868/s050-011-022-0022-7 DOI: https://doi.org/10.3868/s050-011-022-0022-7

Earth Science/ Environmental Science/ Ecology

Soil Ecology Letters
Title: Global-scale analysis reveals distinct patterns of non-ribosomal peptide and polyketide synthase encoding genes in root and soil bacterial communities Author: Barak Dror, Edouard Jurkevitch, Eddie Cytryn Volume: Soil Ecology Letters , 2023, 5(1): 38-45. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0146-2 DOI: https://doi.org/10.1007/s42832-022-0146-2
Title: Microfluidic hotspots in bacteria research: A review of soil and related advances Author: Hengyi Dai, Yajuan Zhuang, Erinne Stirling, Nanlin Liu, Bin Ma Volume: Soil Ecology Letters , 2023, 5(1): 21-37. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0129-3 DOI: https://doi.org/10.1007/s42832-022-0129-3
Title: Influencing factors and partitioning methods of carbonate contribution to CO2 emissions from calcareous soils Author: Zhaoan Sun, Fanqiao Meng, Biao Zhu Volume: Soil Ecology Letters , 2023, 5(1): 6-20. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0139-1 DOI: https://doi.org/10.1007/s42832-022-0139-1
Title: Coming of age for the rhizosphere microbiome transplantation Author: Alexandre Jousset, Seon-Woo Lee Volume: Soil Ecology Letters , 2023, 5(1): 4-5. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0151-5 DOI: https://doi.org/10.1007/s42832-022-0151-5
Title: Umamification of food facilitates the green transition Author: Ole G. Mouritsen Volume: Soil Ecology Letters , 2023, 5(1): 1-3. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0155-1 DOI: https://doi.org/10.1007/s42832-022-0155-1
Title: Effect of arsenite on the proteome of earthworms Eisenia fetida Author: Yali Wang, Yinsheng Li, Hongpei Geng, Qian Zuo, Michelle Thunders, Jiangping Qiu Volume: Soil Ecology Letters , 2023, 5(1): 181-194. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-021-0126-y DOI: https://doi.org/10.1007/s42832-021-0126-y
Title: Activity-density and spatial distribution of termites on a fine-scale in a tropical rainforest in Xishuangbanna, southwest China Author: Myo Thant, Xiaobing Lin, Anjana J. Atapattu, Min Cao, Shang-wen Xia, Shengjie Liu, Xiaodong Yang Volume: Soil Ecology Letters , 2023, 5(1): 169-180. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0141-7 DOI: https://doi.org/10.1007/s42832-022-0141-7
Title: Effects of fertilizer and weed species richness on soil nematode community in a microcosm field experiment Author: Xinli Niu, Yongfan Cheng, Xiaopei Feng, Feng Sun, Yanfang Gu Volume: Soil Ecology Letters , 2023, 5(1): 151-168. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-021-0123-1 DOI: https://doi.org/10.1007/s42832-021-0123-1
Title: Database and primer selections affect nematode community composition under different vegetations of Changbai Mountain Author: Yixin Sun, Xiaofang Du, Yingbin Li, Xu Han, Shuai Fang, Stefan Geisen, Qi Li Volume: Soil Ecology Letters , 2023, 5(1): 142-150. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0153-3 DOI: https://doi.org/10.1007/s42832-022-0153-3
Title: No tillage outperforms conventional tillage under arid conditions and following fertilization Author: Stavros D. Veresoglou, Junjiang Chen, Xuheng Du, Qi Fu, QingLiu Geng, Chenyan Huang, Xilin Huang, Nan Hu, Yiming Hun, Guolin C. Li, Zhiman Lin, Zhiyu Ma, Yuyi Ou, Shuo Qi, Haitian Qin, Yingbo Qiu, Xibin Sun, Ye Tao, YiLing Tian, Jie Wang, Lingxiao Wu, Ziwei Wu, Siqi Xie, Ao Yang, Dan Yang, Chen Zeng, Ying Zeng, RuJie Zhang Volume: Soil Ecology Letters , 2023, 5(1): 137-141. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0145-3 DOI: https://doi.org/10.1007/s42832-022-0145-3
Title: Use of flue gas desulfurization gypsum to reduce dissolved phosphorus in runoff and leachate from two agricultural soils Author: Yumei Mao, Xiaoping Li, Warren A. Dick, Linkui Cao Volume: Soil Ecology Letters , 2023, 5(1): 128-136. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0135-5 DOI: https://doi.org/10.1007/s42832-022-0135-5
Title: Effects of lead pollution on soil microbial community diversity and biomass and on invertase activity Author: Xin Sun, Mingjie Sun, Ying Chao, Xiaoyang Shang, Hui Wang, Hong Pan, Quangang Yang, Yanhong Lou, Yuping Zhuge Volume: Soil Ecology Letters , 2023, 5(1): 118-127. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0134-6 DOI: https://doi.org/10.1007/s42832-022-0134-6
Title: Effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on soil structure and function Author: Baile Xu, Gaowen Yang, Anika Lehmann, Sebastian Riedel, Matthias C. Rillig Volume: Soil Ecology Letters , 2023, 5(1): 108-117. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-022-0143-5 DOI: https://doi.org/10.1007/s42832-022-0143-5
Title: Influence of cadmium and copper mixtures to rhizosphere bacterial communities Author: Qirui An, Yunyang Li, Na Zheng, Jincai Ma, Shengnan Hou, Siyu Sun, Sujing Wang, Pengyang Li, Xiaoqian Li, Chunmei Zhao Volume: Soil Ecology Letters , 2023, 5(1): 94-107. URL: https://journal.hep.com.cn/sel/EN/10.1007/s42832-021-0128-9 DOI: https://doi.org/10.1007/s42832-021-0128-9
Source: https://zhuanlan.zhihu.com/p/587484178

Hey all.. been feeling good lately on azathioprine 100 and colchicine .6 along with 9 different vitamins to keep me feeling somewhat normal. Tonight I had two glasses of red wine about 4 oz each (I rarely drink and this is a decent amount of alcohol for me to feel nice) two hours later and I have the chills like I do when I start to flare and feel quite yucky not hungover feeling or anything of the sort just my normal flare symptoms could the alcohol have triggered a flare? Does this happen to anyone else? Is it in my head maybe PTSD? I’ve been hospitalized countless times for Behcets my last stint being 9 days at UCSF. Any thoughts or opinions would be appreciated. Much love, Rachel.

Here's the As.

• Acetaldehyde (from consuming alcoholic beverages)
• Acheson process, occupational exposure associated with
• Acid mists, strong inorganic
• Aflatoxins
• Alcoholic beverages
• Aluminum production
• 4-Aminobiphenyl
• Areca nut
• Aristolochic acid (and plants containing it)
• Arsenic and inorganic arsenic compounds
• Asbestos (all forms) and mineral substances (such as talc or vermiculite) that contain asbestos
• Auramine production
• Azathioprine

Kind of unbelievable that there are ads everywhere telling us how fun and sexy it is to drink poison?

30F 5’4 100lbs White, Canada Azathioprine 100mg for IBD No drugs, occasional alcohol
Interested in IPL laser to treat a few sun spots on my face. Is this treatment safe while on Azathioprine?
I spoke with my GP as well as my pharmacist and neither of them were able to answer my question.
If it is helpful, I do not have any sensitivity when spending time in the sun (ex. I can spend a whole day at the beach without issue)

30F 5’4 100lbs White, Canada Azathioprine 100mg for IBD No drugs, occasional alcohol
This spot developed quickly (within a few days) and has now been present for 3 weeks. I initially thought it was a sun spot, however it is larger and much more textured than the other spots I have. Any thoughts? It is not painful and does not itch. No flakiness.
I do not have a primary care provider and the waitlist for dermatology in my province is THREE YEARS.
https://imgur.com/a/mf75Obq

Hi there,
Just wondering if any one has noticed any heart weirdness while on Azathioprine or mercaptopurine?
I've been getting a rapid and more forceful heart beat (palpitation) and my chest feels weird and heavy. Can sometimes get worse if I drink alcohol.
Pretty much sucks. It worried me so much I got a cardio-echogram done, but everything looked fine.
Just wondering if this is a common side effect?

I’m not one to burn (unless I sit out for hours with zero sunscreen on). I’ve got olive skin (and not many moles) and when I wear suncream and sunbathe I basically just go brown.
Im being pushed by my GI to try azathioprine next (as it seems 5asas not quite enough). Im worries about the skin cancer stats, I love going on holiday and lying on the beach and sitting in my garden in the summer. Basically I love being tanned it makes me happy! UC has already taken away being able to drink alcohol from me!
Basically is the skin cancer risk as much of a risk for someone who is generally ok in the sun? Of course I’ll apply factor 50 ( I already do use suncream as it’s sensible) but the thought of having to wear uv clothing etc just depresses me.
Just to add - firstly I’m sorry as I’m aware the way I’ve explained that isn’t the best! Secondly, it’s frustrating as my flare isn’t that bad at all (1 BM a day, sometimes blood) so it’s hard to accept that something as strong as an immunosuppressant is the next step for me. Also, I’ve tried steroids and budesonide does the trick for me, but I can’t maintain remission when I come off it.

37M, white, 6’, 165# with a couple very rare conditions I thought I’d check to see if someone in this community has any insight on. I am seeing really great doctors at Stanford and the Mayo Clinic but I’m having a rough time recovering because there doesn’t seem to be a tangible path to normalcy.
Some background…
I was diagnosed in 2013 with a rare autoimmune disease called IgG4-related disease - with its presentation of a fibrotic mass in my mesentery that can’t be removed. It occluded my SMV but I have developed varices around it to compensate. I tried a couple courses of prednisone and was ultimately put on azathioprine, and took that medicine for about 8 years. In December 2021, I had some abnormal liver levels followed by intense pain. Fast forward to a couple scans and a liver biopsy later, I was diagnosed with azathioprine-induced Veno-occlusive disease (VOD). My liver looks full blown cirrhotic in my scans. My spleen in enlarged, stomach inflamed, and I have esophageal varices.
I know VOD typically happens in bone marrow transplant patients and is usually caught early and reversible but I think the damage done here is pretty substantial.
Docs don’t really have a playbook for what the path to recovery looks like. “It could take over a year to heal itself.” “It might not heal itself at all.” I’m a very visual oriented person and if I can see a path to recovery I’m fine with it taking a long time. But in this instance it’s watch and wait and we don’t know what’s gonna happen.
Some of my liver levels have gone down, Some are still elevated or climbing. I’m in pain around the clock, I’ve lost 25 pounds, don’t have a lot of stamina, and have not sleeping well. I’ve been alcohol free for 6 months, eat mostly healthy home-cooked meals, and started incorporating light exercise and movement.
If anyone can provide some insight on recovery, that would be great. Also curious if and when I’d need a liver transplant if my liver doesn’t heal.
Thank you!!!

Hi Behcets,
I'm (24/f) relatively recently diagnosed and I have tried quite a few different medications for controlling flares (Colchicine, Methotrexate, Azathioprine) with minimal luck. From January to March I was on a strong course of tapered prednisone for a flare that I just couldn't seem to kick.
During this time, I started doing some research into diets. I've been on keto, high-protein, gluten-free - you name it, I've tried it in an effort to try and reduce inflammation. I came across this study - which essentially put Behcets patients on either a Mediterranean diet or a Lacto-Ovo vegetarian diet to reduce flare-ups and coinciding symptoms. It seemed somewhat promising. I also remembered when I was vegan for around a year and a half, I never had any flares.
I also remembered that colchicine is a gout medication, and how a low purine diet (which limits foods high in uric acid) is recommended for patients with gout. These diets typically recommend limiting game meats, red meats, and liver. Along with alcohol and shellfish.
Anyways, I decided to follow a vegetarian diet and try to limit other things linked to high uric acid content. Since tapering off prednisone and waiting for Otezla approval from my insurance, it's the first time I've actually been off medication. Since following this diet I have seemed to have any flares, even small ones (knock on wood). I've since started Otezla and I am actually still flare-up free. This is unheard of for me, I usually always have 2-3 ulcers in my mouth even when I am not in an active flare-up. My joint pain has also been reduced significantly.
Keep in mind this could be an absolute fluke (also, I love meat and I am not in any way saying it's bad for anyone!) and I might just be in a flare-free period, but I wanted to ask if anyone has found reducing or cutting meat to be beneficial or harmful for their flares?
Hope you have a good day!