Serotonin syndrome effexor buspar

Does anybody know how seratonin syndrome works?? I have none of the symptoms and I’m not worried I have it at all but as my fellow anxious people know, anxiety is not reasonable. My dr and I decided I should go up to 100 mgs and I’ve been on Zoloft for almost a decade. I read about seratonin syndrome in passing and now I’m anxious about it. Going up 25 mg’s of a med I’ve been on for so long wouldn’t cause it right??

Felt really stupid afterwards when I realized I hadn’t looked at the interactions and warnings. I’m on 10mg of Lexapro (for 1.5 years now) and just took 20ml of Robitussin MD maximum strength.
Panicking now, as I’m taking lexapro for anxiety. Tried to vomit after but don’t think any of it came out. I normally take my daily dose around 8pm. I took the cough syrup around 5pm. Can’t decide if I’m better off skipping my dose tonight to lower serotonin syndrome risk? Any advice?
Thank you in advance 🥺

Starting at 25 mg tomorrow. I have three kids this won’t screw up me taking care of them for the day? Like I’m not gonna feel like an absolute zombie or want to sleep all day? I’m sort of scared yet I’ve been dying to try it.
I see posts about being short of breath on it and heightened anxiety, yikes. I already have severe anxiety paranoia to begin with and I’ll get psychosomatic symptoms just from my anxiety alone. I don’t want this to make it worse I’m really freaked out now.
I just want to be able to function. I’m Getting over strep throat I’ve been so sick lately and when I read it can make you short of breath it scared me because I’m already feeling short of breath from my congestion and being sick so much. I’m in an antibiotic which I’m also afraid it’ll interact with the med, I’m terrified of serotonin syndrome and the pharmacist said no it’s all good but I don’t trust anyone.
I know in order to know if it works I have to put on my big girl pants stop self sabotaging and just fucking do it. Someone enlighten me, educate me or make me feel a better about this hopefully “great” medicine.

Maybe the...

• Zoloft
• Wellbutrin
• Lexapro
• Celexa
• Effexor
• Prozac
• Buspar
• Seroquel
• Cymbalta

...9th time is the charm?
Keep having negative side effects either immediately, after a couple refill cycles, or contraindications and just so exhausted going through the same "wait 2-6 weeks" to see if it's going to work or not.
Just venting and hoping other people can relate to the struggle of finding the right meds because I'm feeling pretty worn down by it all

I’ve been a pharmacist for about a year and while initially thinking all drug interactions were the biggest deal in the world (oh my god, serotonin syndrome risk!!!), I realized a lot of them are overblown and the vast majority of the time, I just consult the patient on the interaction and what they may experience. I only delay therapy and get clarification from doctor on certain ones (benzo opioid from different doctors, two opioids, amiodarone warfarin, etc.) but recently I worked with a pharmacist who would literally call on everything.
Am I just doing my job incorrectly or are they just too cautious? Considering I don’t leave the patient in the dark on the interaction, I don’t think I’m doing them a disservice but what do you think?

Hi, so I'm a male, 24 years old, I've been on setraline aka Zoloft for 2 years at 50mg, i got into working out again couple months ago and i wanted to start taking creatine in my supplements, though I've found some people are saying it causes serotonin syndrome if you take creatine while on antidepressants, how true is that? And is it safe to consume both? Any advice or help would be greatly appreciated!

30 Female 250lb 5'7"
So I want to start this by saying that I have a huge fear of serotonin syndrome due to past medical experiences. I'm autistic with adhd comorbidity and have been trying for a while to find the right meds to be functional. Right now I've been given a new medication and I can tell my anxiety has been a bit all over. But I wanted to check if this all was ok.
25mg sertraline 100mg buproprion 10mg atomoxetine
I know these are baby doses, I have a really high sensitivity to these meds, but I don't want my anxiety over SS to keep me from taking the new atomoxetine because it has been really helpful.
I just don't want my anxiety to keep me from something good.

Hi
The reason im on antidepressants is severe crippling post acute withdrawal syndrome caused by heavy synthetic weed abuse..
I tried SSRIs with no help... mirtazapine and wellbutrin too...
Then i tried cymbalta with seroquel and FINALLY felt something... my anxiety got better but i still experience pretty bad lows.. mood swings..
So now me and my doc have decided to give effexor a try... im still cross tapering so its way too early to judge anything... all i can say is that so far im handling the cross taper well...
I just have one question.. being that cymbalta and effexor are both SNRIs, did anyone find success with effexor after failing cymbalta or only gettinng a partial response from it ?

Someone in DMT asked about combining Syrian rue with moclobemide. My reply was too long to post in the topic, so I figured I'd post it here. I tried to give a balanced view (keep in my mind, I'm still learning and didn't even feel like making the post, I just wanted to use it as an opportunity to prevent the further spread of MAOI hysteria). I referenced posts in this subreddit in the post.
 
I don't recommend it, and I don't even recommend moclobemide on its own, but I've seen people in MAOIs report that they've experimented with combining MAOIs.
I've noticed while experimenting around that Nardil has almost no effect on me when taken alone, but that it works much stronger than even 90MG of Parnate when I take medium (30 & 45) doses of both.
u/extremity4, https://www.reddit.com/MAOIs/comments/w8qyrw/does_maoinhibitorscom_allow_maoi_combining/
I recently started testing adding a low dose of parnate to 30mg of nardil. I have been on Nardil for many months, but I'm still lacking energy, motivation and good mood.
u/konibak, https://www.reddit.com/MAOIs/comments/v79giw/nardil_parnate_fatigue_and_somnolence/
Most people believe that MAOIs are wildly reactant with lots of things, but this is a myth. The foremost person who is working to dispel this myth is Ken Gillman of PsychoTropical.org and some people in MAOIs and socialanxietysupport.com have used his writings to encourage themselves to experiment.
It is, unfortunately, necessary to state clearly from the beginning that much of what is published by doctors in books and journals about MAOIs is either poorly informed, or just plain wrong. As an example, much of the information that comes with MAOIs (the PI, or product information sheet) contains inaccurate material concerning, among other things: serotonin toxicity, drug interactions generally, and dietary tyramine.
MAOIs (Parnate, Nardil): Misconceptions and Questions No. 1. Ken Gillman, MD. PsychoTropical Research. Nov. 14, 2012
To give another controversial example, the last person quoted has also experimented with combining an MAOI with dextroamphetamine:
Dexedrine and Nardil
Indeed, dopaminergics, are not as risky as serotonergics, as implied here:
Drug interactions for the RIMAs [reversible inhibitors of MAO-A] include interaction with SSRI antidepressants, which can cause the 5-HT syndrome (see the discussion of SSRIs). The effect of stimulant drugs, such as methylphenidate and dextroamphetamine (used to treat ADHD), may be increased. Some over-the-counter cold and hay fever decongestants (i.e., sympathomimetic amines) can have increased stimulant effects. Selegiline, a selective MAO-B used for Parkinson disease, should not be used concurrently with the RIMAs. Unlike the irreversible MAOIs, no significant interactions with foods occur because the selective inhibition of MAO-A does not stop the metabolism of tyramine.
Foye's Principles of Medicinal Chemistry, Seventh Edition. Thomas L. Lemke, Ph.D., David A. Williams, Ph.D., Victoria F. Roche, Ph.D., S. William Zito, Ph.D. (2013). (21. Antidepressants. Reversible MAO-A Inhibitor Antidepressants)
And indeed methylphenidate (Ritalin) is safe to combine with MAOIs according to ‘The prescriber’s guide to classic MAO inhibitors for treatment-resistant depression’,[1]
Gillman goes a step further an states 'There is now a lot of accumulated experience of the concurrent administration of MAOIs and amphetamine for therapeutic purposes in depression. It is safe when done carefully.'[2] However, he does point out that there have been deaths from this combo: 'There are various case reports of fatalities with over-doses of MAOIs and Amphetamine [28-34].'[2] And, indeed, numerous people have reported using this combination on the Internet.[3] However, one person reported that after combining Nardil with 'varying amounts of meth, come, crack and Ritalin,' on over 25 occaisons he was diagnosed with 'drug induced congestive heart failure at 27 after having a massive heart attack from combining a grain of rice sized piece of meth with Nardil while mildly drunk and in minor lyrica withdrawal.'[4]
So, getting back to the topic of the post, combing two MAOIs seems like an unnecessary risk, as does mixing drugs that are similar to each other in general (sounds like it would overload the receptors). Just because some people like to be greedy with their medicating doesn't mean they aren't causing subtle damage. I don't even trust the way moclobemide feels, on its own. The mentioned combos, also seem like an unnecessary risk, but what I like about these types of reports is they help to dispel the myth that MAOIs are ridiculously dangerous. B. caapi, itself, contains a serotonin reuptake inhibitor (tetrahydroharmine) in addition to MAOIs, and that's supposedly a taboo combination, and yet ayahuasca is a well-established substance. One tribe was even observed to boost the levels of THH in their brews (there's an herb that contains only THH).[5] THH has been described as weak, so the reason it doesn't react badly with the MAOIs is what Gillman says: ‘the dose makes the poison’ (Paracelsus).[2] Coca has also been added to ayahuasca brews.[6][7] There was even a clinical trial where moclobemide was combined with an SSRI,[8] although, ironically, Ken Gillman is against that study.[9]
[1] The prescriber’s guide to classic MAO inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression. Van den Eynde V, Abdelmoemin WR, Abraham MM, et al. CNS Spectrums. 2023;28(4):427-440. doi:10.1017/S1092852922000906
[2] 18. CNS ‘Stimulants’ and MAOIs Part 2. Psychotropical Research. Ken Gillman, MD, 2022, 2023
[3] https://www.reddit.comPA99/s/Epy4BpuLRI
[4] u/No-Tap9133, https://www.reddit.com/MAOIs/comments/1cc8nz9/comment/l17vq64/
[5] https://www.reddit.com/anahuasca/comments/17f16ag/calliandra_pentandra_another_source_of/
[6] Although B. caapi can be the sole ingredient of the tea[7], up to 100 different plants have been described as admixtures to ayahuasca. These plants contain a wide variety of psychotropic substances such as nicotine (from Nicotiana spp.), scopolamine (from Brugmansia spp.), caffeine (from Ilex guayusa and Paullinia yoco), cocaine (from Erythoxylum coca) and N,N-dimethyltryptamine (DMT, from Psychotria viridis and Diplopterys cabrerana)[2, 8.]
The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro. Morales-García JA, de la Fuente Revenga M, Alonso-Gil S, Rodríguez-Franco MI, Feilding A, Perez-Castillo A, Riba J. Sci Rep. 2017 Jul 13;7(1):5309. doi: 10.1038/s41598-017-05407-9
[7] Guillermo: We’re going to take a very strong preparation made of eight plants. Besides ayahuasca and chacruna, there will be toé (datura), bobinsana, chay, coca, marosa, and piñon blanco!
[8] Combining antidepressants: a review of evidence. Palaniyappan L, Insole L, Ferrier N. Advances in Psychiatric Treatment. 2009. 15(2):90-99. doi: 10.1192/apt.bp.107.004820 (See 'SSRI with moclobemide')
[9] One example of a serious mistake is the suggestion that it is OK to combine imipramine with MAOIs, and moclobemide with SSRIs (84) — that has a risk of inducing fatal serotonin toxicity.
84. Palaniyappan, L, Insole, L, and Ferrier, N, Combining antidepressants: a review of evidence. Adv Psychiatr Treat, 2009. 15: p. 90-99.
7. Gillman’s Antidepressants algorithm. Ken Gillman, MD, PsychoTropical Research, Nov 2016, Nov 2023

I went to the psychiatrist to get back on my ADHD meds and to get an evaluation because I’ve been sorta stuck on the couch doom scrolling all day. I actually get paid to sit on my ass all day for “taking care” of my non verbal uncle with Down syndrome. My family keeps telling me to get another job because it’s only $5/hr for a maximum of 6hrs a day but it’s just so hard to open up indeed or go out and ask for resumes. My doc prescribed me with Buspar and Zoloft but no ADHD meds. I only ever feel anxious when I take ADHD meds but other than that I’m pretty chill. The doctor said I have a chance of developing anxiety in the future because of how I react to my ADHD meds. The Zoloft to me doesn’t make sense because I don’t ever feel sad really, but then again most of the time I don’t know what I feel.

i’m almost one week on lamictal. this is a vent, with some questions. cw, paranoia around medication. i know this is long but please i need some answers. all of the text below is important.
i got serotonin syndrome about 4 weeks ago from an SSRI combined with adderall. i was already super afraid to take medication before then because ive taken 6 medications beforehand and had bad interactions with half of them, and my psychiatrist was fighting with me to just try it.
24hrs after my first dose, and the serotonin syndome fully set in. i wont get into it, but it was fucking traumatizing going through that, especially after being so afraid initially to try it…
ever since then, i’ve been super paranoid about medication. but i started lamictal anyways, because i was having a mental health crisis, and could not function at all. i was like fuck it, if this makes me worse i’ll go to inpatient.
why am i telling you this? well, here’s the thing. i kind of like lamictal. like, it makes me feel pretty normal, and the best i’ve felt in a while, mentally. but the physical side effects kind of suck, and when it wears off in the afternoon, i feel NOT okay… just weird, and physically sick. and it’s triggering my paranoia and somatic OCD.
i’m incredibly fearful that i’ll have a bad reaction to the drug eventually. i’m also afraid it’ll fuck my mind up too. i have an intense fear of losing my grip on reality, like the way i did when i was suffering from serotonin syndrome. i don’t want to get worse mentally, or get physically sick. idk. like i said before, im extremely paranoid.
i’m scared that i’ll have to do a dosage increase in the future, for whatever reason. i don’t know if i can do it. i see some people in this sub talking about increasing their dosage from 25mg to eventually 100mg, or higher.
why? how do you know if you need an increase? will i have to do that eventually??? will my tolerance of the lamictal just rise, until i need to increase the dosage again? and AGAIN? i don’t know if i can deal with that, or if i will be able to force myself to continue taking the meds if i get even a dosage increase to 50mg.
idk guys. i’m so afraid. i have to force myself to take it every morning and i go through the whole day with the fear of getting sick due to the meds, or my mental health getting worse. i hate being mentally ill. lol i really hope somebody answers this. i dont trust my psychiatrist at all after she prescribed me two meds that are KNOWN to have bad reactions… i need somebody who’s also taking Lamictal to answer the questions in the paragraph above.

Hi,
I have marked most important parts as how long I use each meds in what dose, info of me, my questions, supplements used, nootropics thinking of, new meds for panic disorder treatment, plan to quit benzos, advice about Memantine. If you want, there is whole story and treatment:) Thx I have a lifetime nonmedicated ADHD + OCD (will finally have atomoexin in july after like 8 docs) but mainly severe panic disorder since 12/23 caused by badly burning out and not stopping work + too much stress from all sides, mostly family and workspace/company. It started close to xmas and wanted to finish year and worked until my body completely disabled to it to me but right after it came xmas, which is not my fav time of year ending in keeping me in attacks 24/7. Btw Im 29yo man, 193cm, 90kg, sporting, financial advisor solo businessman, living alone, used to be really busy all the time and I want to be healthy and free! Lesson learned, did major changes in life, know I have limits and can say NO to people.
I am currently getting off xanax and on SSRI, starting my new recovery plan below as previous didnt help enough and asking if you know anything that could help me get my full life back sooner I work as I can/want, mostly 2-6 h/day and only from home, going to multiple types of therapy, investing insane money to get recovered and looking for every possible way. I am open for any tip or advice on nootropic, peptide, maybe even SARMs that could help me get over this. New meds are imo most I can use, wanna get rid of addictive stuff and SSRI, ideally only buspiron + non addictive anxiety meds, or SNRI/Bupropion instead of Citalopram. . Even if you dont have time or dont want to read all previous treatment and new plan and have idea what could help me, write it please. But I have to be careful with anything interacts with SSRI as I will be also on buspar, I have a safe med for serotonin syndrome if needed.. Also if you see gaps or risks in my meds plan, some ideas, useful info or better ways, I will be glad to know it:)
I use/tried almost every useful supplement wo AD interaction including adaptogens, herbs, expensive vitamins, mushrooms, gotu kola, NAC, tyrosine, inositol and just anything that could be useful + basics use all year. Also have Alpha GPC which made my adhd brain supercomputer before I got beaten but now doesnt work. Tried before noopept and a lot of racetams, idra21 and some more but with no effect and modafinil before with effect, but mostly anxiety, too much concentrating on one thing and severe insomnia.
I am already pretty sure about Agmatine, Sulbutiamine instead of Benfotiamine (any difference?), not sure of Bromantane on ssri (?), 9-me is no go guess, maybe NALT (?), Theacrine as Im tired from SSRI all the time and too much coffee makes me axnious, maybe Vinpocetine or Uridine triacetate? centrophenoxine? dihexa?
My treatment from december to now:
I had no idea wth is this, told my psychologist what is happening to me and asking many times if its serious and casually replied that is probably from stress. So I treated it as burnout by resting, then removing original causes and triggers, removing problems from my mind and life, reducing stress to minimum, even leaving my pretty good paid job after 9 yers. But nothing helped besides benzos which made me not feel attacks so much and when I went off after 6 weeks, symptoms came back the same day.
I always said no to ADs but this time I didnt see any other option besides staying on benzos for a long time so I got SSRI citalopram 20, later 30mg now 6 weeks, first weeks were hell of anxiety and tiredness, last 2 weeks they help but effect is enough to keep me attack free only at home, outside flat still almost instant PA + side effects are still bad.
Same with benzos now again for 6 weeks afte break from previous cycle, mostly xanax 1,5-2mg a day, when Im home with no problems I can stay on 0,5mg with no WD. But want to quit asap, Im standing on the edge of little discomfort or living hell WDs. Also it makes me dumb, careless and not caring, but dont have cravings or abuse them, until now there was no other medication in my country :/ Also I already had GABA WDs pretty bad from alcohol many times and from phenibut in february by mistake (3 weeks of 2-3x a week before I had benzos). I would rather skip this opportunity to be on boat walking simulator with scary shadowy guy in my bedroom.
Next week I will make a big changes:
Will to add Buspar in small doses to SSRI, probably 30mg citalopram + 2x7,5mg buspar for long term and propranolol instead benzos before I leave flat for panic attacks - I have mostly physical symptoms and over these months my brain has learned to go panic mode when I go around people or noise but im not scared, wanting to hide or anxious, want to go out. Hope this will allow me to relearn the BIOS of my brain and body they wont start panicking as it has learned over months of nonstop attack (january until end of april, just moving on scale 1-10 but never off). Propranolon as beta-blocker should not allow my body to go panic defense mode and mental anxiety I can handle now. My mind is still quite ok, not much depressed or in bad mood, last days even thinking a bit sharper and can handle it but body/brain program are stuck. Hope this will allow me over time to get off SSRI to just Buspar + non addictive anxiety aid as needed or at least switch to SNRI or Wellbutrin as im energetic person but with this SSRI im meeeeeeeh all the time.
As propranolon arrives I will cut benzos to lowest dosage where I wont feel WD, probably 0,5mg/day and switch to Clonazepam (have benzos and can ask doc anytime), keep this dose for 2-3 weeks, taper to 0,35mg, wait and this until i go down around 0,2mg/day. Maybe slower if it will be painful or risk worse WDs when i cut them off.
For quitting benzos I have clonidine (WD reduce, camling, ADHD), pregabalin (GABA substance replacement, anti seizure but addictive), baclofen (GABA substance replacement, anti seizure also addictive)), Etifoxine (nonbenzo anxiolytics, I guess mostly PAWS) and Topiramate (seizure and migraine prevention, WD reduce) and Hydroxyzine (sleepy antihistamine nonaddictive) to get off them asap with no risk seizure and suffering for weeks in terrible WDs. I wont use all the aids together but as needed for current symptoms and not get hooked on none of them as only atarax is safe in long term.
Also finally will get ADHD meds atomoxetin, but as I have no energy, even adhd is not so present and clonidine also helps for adhd. And I have found one super special med you will be interested about- Memantine, do you have experiences about this so called miracle drug? It make you feel softly with unlimited brain power, also it shall lower tolerances to almost all substances and by 30-60% over 7-14 days and then make WDs easier + also helps ADHD. But have no idea when to use it in my plan, I got 2 packs and its cheap so can buy more but dont want to mess with getting off bzs and learning to manage going out. Same question with atomoxetin - when to start? its not stimulant so it should not affect attacks nor benzo WD but idk.
Just in case there would be too much serotonin I will have Cyproheptadine for SS. It should not happen from SSRI+Buspiron but some nootropic or WD med can cause it.
I will still go for checks to doc and psychiatrist but the medical procedures in my country got stuck in time in year when producers of SSRI/benzos gave some gifts for doctors or politics. So they just give you this combo announcing you it will work (didnt) and you wont get addicted in 3 months of xan (would). Mainly propranolon is not approved med for anxiety/panic in my county, only bzds and buspirone, but after trying several ADs on you :/
Thank you so much for any knowledge you share with me!

Hi,
I’m in Australia where Wellbutrin isn’t used much. It’s licenced for short term use for smoking cessation only. But I’m getting it prescribed off label for my chronic severe depression. I’ve tried basically all the SSRIs, SNRIs, mirtazapine, seroquel, brintillex, Valdoxen, Amitriptyline before now.
I’m inpatient currently and also having a course of TMS which I’m halfway through. I’m coming off Sertraline to try Wellbutrin. I see in the US it’s used a lot AS WELL AS an SSRI, so here lies my question.
My treating team have got me doing this switch SO slowly. They’ve reduced my sertraline from 100mg to 50mg and want me on 50 for a full week! I’ve asked about doing this quicker, but they keep banging on about serotonin syndrome. I just don’t get it especially if they’re used together in other countries. Is there any need for this process to be dragged out so long? Or theoretically could I reduce the sertraline to 25mg in a couple days then start straight onto Wellbutrin after that?
If this process is going to take weeks like they want to do - I’m not sure I’m up for it to be honest so just looking for opinions from people where it’s more commonly used. I’m wondering if they’re just being unnecessary over cautious due to no real experience prescribing Wellbutrin due to its very rare use in Australia.
Thanks in advance

Anyone run into pharmacy not willing to fill a maoi and adjunct?
I take parnate which surprise is causing insomnia. Tried a few meds and last one was mirtazapine. It was for 7.5mg and I halved it. No luck and stopped taking it.
CVS, which is the cheapest option to fill the parnate, roughly $75 savings over any other pharmacy including my preferred hospital university pharmacy. They signed off on it and we had the serotonin syndrome. Now it’s a problem and they discontinued my refill of parnate without letting me know.
The doctor and myself stated I was no longer taking the mirtazapine but they still discontinued the parnate perscription. The university pharmacy will also not fill the prescription as well. I’m now two days without parnate and it’s starting to get rough.
I’m in the process of finding a new pharmacy but it’s hard to find any that have it in stock and of course it’s Friday afternoon.
I’m worried I’m going to need an adjunct at some point that will need a strong prescriber backing. My psychiatrist says he has experience with maois but I’m finding out that is not super spot on, I’m his first patient to go past 50mg and have to send him research articles.
Anyone have any luck using a pharmacy for maoi and adjuncts? Anyone know of a list of maoi prescribers in the US? I’ve saw the maoihibitors website but i don’t think my PCP would feel comfortable prescribing adjuncts if needed.

Here we are again lol buspar as needed ?
I’m so frustrated! Effexor works amazing for me I’m in 75 mg but I feel I need more for situational things and yet again a doctor prescribed Buspar as needed, but I thought it couldn’t be taken as needed!? I can’t do propranolol because of my blood pressure or so they say as I have a lot of physical things that don’t seem to go away.. I would like to privacy by saying I did take Buspar previously three times a day and it did take the edge off, but this was before effect her and I just don’t want to backtrack so I’m scared but also I take magnesium and worry that will make me feel worse so obviously I have medication anxiety that’s always gonna be a thing because I know medicine is not a fix all I want some relief with my physical stuff

Hi all,
Diagnosed: panic disorder, GAD, anxiety induced depression
Short background: was on SSRI Sertraline for 10 years which worked great for my anxiety until someone spiked my drink and gave me serotonin syndrome last year. Ever since then, I can no longer tolerate SSRIs/SNRIs and have had a rough year after having to come off a lot of them cold turkey due to serotonin toxicity reaction. Now VERY sensitive to any kind of medication.
Have recently been on antipsychotic quetiapine/seroquel at a low dose which made me extremely tired and also bad side effects with extrapyramidial symptoms including involuntary muscle twitching and spasms but it did help slightly for anxiety. Have reduced that right down so I’m only taking at night to help me sleep and plan is to come off that soon.
Started lamictal today at 25mg and feel incredibly stimulated like I’ve taken speed. I had similar with pregablin in the past which was too much for me. Will the stimulating feeling of lamictal settle down? It does seem to have calmed my anxiety but I feel like running and doing 10,000 things at once. I’ve just taken low dose diazepam to take the edge off.
Thanks all ☺️

I usually take my meds at around 11am. It’s currently 9am. I would just take it at the usual time, but I have someplace to be soon and I won’t be home at 11 to take it. Would it be okay to take my two hours early? I get paranoid a lot about serotonin syndrome and just wanna make sure I’d be in the clear

I’ve always struggled with anxiety and OCD as a whole - social, scared thoughts things will happen if I’m alone, can’t relax etc BUT it tends to come and go. Some weeks I am good but if I start having anxiety for any reason then it just sticks in my head for weeks and it’s all I can think about! I recently got prescribed 10mg Prozac but I am scared to start it due to some weeks being good and less anxiety. Do you think I really need it, or should I try other coping skills.
Has anyone else experienced this? Also, I get concerned with taking it and getting serotonin syndrome! Is this common or do you know of anyone who has actually experienced this?
FYI- I was prescribed 10mg.

Hi,
I have marked most imporant parts as how long I use each meds in what dose, info of me, my questions, supplements used, nootropics thinking of, new meds for panic disorder treatment, plan to quit benzos, asking about Memantine. If you want, here is whole story and treatment:) Thx I have a lifetime nonmedicated ADHD + OCD (will finally have atomoexin in july after like 8 docs) but mainly severe panic disorder since 12/23 caused by badly burning out and not stopping work + too much stress from all sides, mostly family and workspace/company. It started close to xmas and wanted to finish year and worked until my body completely disabled to it to me but right after it came xmas, which is not my fav time of year ending in keeping me in attacks 24/7. Btw Im 29yo man, 193cm, 90kg, sporting, financial advisor solo businessman, living alone, used to be really busy all the time, multiple addictions behind me mostly because depression (alcohol),pain (kratom) and stimulants bcs its so addictive with adhd :D But I dont abuse anything since 02/23 when I barely survived WD from forced CT a lot of alcohol every day and I want to be healthy and drugs free!
I am currently getting off xanax and on SSRI, starting my new recovery plan below as previous didnt help enough and asking if you know anything that could help me get my full life back sooner I work as I can/want, mostly 2-6 h/day and only from home, going to multiple types of therapy, investing insane money to get recovered and looking for every possible way. I am open for any tip or suggestion on nootropic, peptide, maybe even SARMs that could help me get over this. Even if you dont have time or dont want to read all previous treatment and new plan and have idea what could help me, write it please. But I have to be careful with anything interacts with SSRI as I will be also on buspar, I have a safe med for serotonin syndrome if needed.. Also if you see gaps or risks in my meds plan, some ideas, useful info or better ways, I will be glad to know it:) Mostly about Memantine - when to use, in which part of protocol it will be most beneficial or what to expect.
I use/tried almost every useful supplement including adaptogens, herbs, expensive vitamins, mushrooms, gotu kola, NAC, tyrosine, inositol and just anything that could be useful + basics use all year. Also have Alpha GPC which made my adhd brain supercomputer before I got beaten but now doesnt work. Tried before noopept and a lot of racetams, idra21 and some more but with no effect and modafinil before with effect, but mostly anxiety, too much concentrating on one thing and severe insomnia.
I am already pretty sure about Agmatine, Sulbutiamine instead of Benfotiamine (any difference?), not sure of Bromantane on ssri (?), 9-me is no go, maybe NALT (?), Theacrine as Im tired from SSRI all the time and too much coffee makes me axnious, maybe Vinpocetine or Uridine triacetate? centrophenoxine? dihexa?
My treatment from december to now:
I had no idea wth is this, told my psychologist what is happening to me and asking many times if its serious and casually replied that is probably from stress. So I treated it as burnout by resting, then removing original causes and triggers, removing problems from my mind and life, reducing stress to minimum, even leaving my pretty good paid job after 9 yers. But nothing helped besides benzos which made me not feel attacks so much and when I went off after 6 weeks, symptoms came back the same day.
I always said no to ADs but this time I didnt see any other option so I got SSRI citalopram 20, later 30mg now 6 weeks, first weeks were hell of anxiety and tiredness, last 2 weeks they help but effect is enough to keep me attack free only at home, outside flat still almost instant PA + side effects are still bad.
Same with benzos now again for 6 weeks afte break from previous cycle, mostly xanax 1,5-2mg a day, when Im home with no problems I can stay on 0,5mg with no WD. But want to quit asap, Im standing on the edge of little discomfort or living hell WDs. Also it makes me dumb, careless and not caring, but dont have cravings or abuse them, until now there was no other medication in my country :/ Also I already had GABA WDs pretty bad from alcohol many times and from phenibut in february by mistake (3 weeks of 2-3x a week before I had benzos). I would rather skip this opportunity to be on boat walking simulator with scary shadowy guy in my bedroom.
Next week I will make a big changes:
Will to add Buspar in small doses to SSRI, probably 30mg citalopram + 2x7,5mg buspar for long term and propranolol over benzos before I leave flat for panic attacks - I have mostly physical symptoms and over these months my brain has learned to go panic mode when I go around people or noise but im not scared, wanting to hide or anxious, want to go out. Hope this will allow me to relearn the BIOS of my brain and body they wont start panicking as it has learned over months of nonstop attack (january until end of april, just moving on scale 1-10 but never off). Propranolon as beta-blocker should not allow my body to go panic defense mode and mental anxiety I can handle now. My mind is still quite ok, not much depressed or in bad mood, last days even thinking a bit sharper and can handle it but body/brain program are stuck. Hope this will allow me over time to get off SSRI to just Buspar + non addictive anxiety aid as needed or at least switch to SNRI or Wellbutrin as im energetic person but with this SSRI im meeeeeeeh all the time.
As propranolon arrives I will cut benzos to lowest dosage where I wont feel WD, probably 0,5mg/day and switch to Clonazepam (have benzos and can ask doc anytime), keep this dose for 2-3 weeks, taper to 0,35mg, wait and this until i go down around 0,2mg/day. Maybe slower if it will be painful or risk worse WDs when i cut them off.
For quitting benzos I have clonidine (WD reduce, camling, ADHD), pregabalin (GABA substance replacement, anti seizure but addictive), baclofen (GABA substance replacement, anti seizure also addictive)), Etifoxine (nonbenzo anxiolytics, I guess mostly PAWS) and Topiramate (seizure and migraine prevention, WD reduce) and Hydroxyzine (sleepy antihistamine nonaddictive) to get off them asap with no risk seizure and suffering for weeks in terrible WDs. I wont use all the aids together but as needed for current symptoms and not get hooked on none of them as only atarax is safe.
Also finally will get ADHD meds atomoxetin, but as I have no energy, even adhd is not so present and clonidine also helps for adhd. And I have found one super special med you will be interested about- Memantine (bgpharm), do you have experiences about this so called miracle drug? It make you feel softly with unlimited brain power, also it shall lower tolerances to almost all substances and by 30-60% over 7-14 days and then make WDs easier + also helps ADHD. But have no idea when to use it in my plan, I got 2 packs and its cheap so can buy more but dont want to mess with getting off bzs and learning to manage going out. Same question with atomoxetin - when to start? its not stimulant so it should not affect attacks nor benzo WD but idk.
Just in case there would be too much serotonin I will have Cyproheptadine for SS. It should not happen from SSRI+Buspiron but some nootropic or WD med can cause it. And just remembered I shall take some ephedrine/yohimbine if my BP or HB goes too slow from propranolon/clonidine... :/
I will still go for checks to doc and psychiatrist but the medical procedures in my country got stuck in time in year when producers of SSRI/benzos gave some gifts for doctors or politics. So they just give you this combo announcing you it will work (didnt) and you wont get addicted in 3 months of xan (would). Also propranolon is not approved med for anxiety in my county, only bzds and buspirone, but after trying several ADs on you :/
Thank you so much for any knowledge you share with me!

Hi,
I have marked most imporant parts as how long I use each meds in what dose, info of me, my questions, supplements used, nootropics thinking of, new meds for panic disorder treatment, plan to quit benzos, advice about Memantine. If you want, there is whole story and treatment:) Thx I have a lifetime nonmedicated ADHD + OCD (will finally have atomoexin in july after like 8 docs) but mainly severe panic disorder since 12/23 caused by badly burning out and not stopping work + too much stress from all sides, mostly family and workspace/company. It started close to xmas and wanted to finish year and worked until my body completely disabled to it to me but right after it came xmas, which is not my fav time of year ending in keeping me in attacks 24/7. Btw Im 29yo man, 193cm, 90kg, sporting, financial advisor self employed, living alone, used to be really busy all the time, multiple addictions behind me mostly because depression (alcohol),pain (kratom) and stimulants bcs its so addictive with adhd :D But I dont abuse anything since 02/23 when I barely survived WD from forced CT a lot of alcohol every day and I want to be healthy and drugs free!
I am currently getting off xanax and on SSRI, starting my new recovery plan below as previous didnt help enough and asking if you know anything that could help me get my full life back sooner I work as I can/want, mostly 2-6 h/day and only from home, going to multiple types of therapy, investing insane money to get recovered and looking for every possible way. I am open for any tip or advice on nootropic, peptide, maybe even SARMs that could help me get over this. Even if you dont have time or dont want to read all previous treatment and new plan and have idea what could help me, write it please. But I have to be careful with anything interacts with SSRI as I will be also on buspar, I have a safe med for serotonin syndrome if needed.. Also if you see gaps or risks in my meds plan, some ideas, useful info or better ways, I will be glad to know it:) Mostly about Memantine - when to use, in which part of protocol it will be most beneficial or what to expect.
I use/tried almost every useful supplement including adaptogens, herbs, expensive vitamins, mushrooms, gotu kola, NAC, tyrosine, inositol and just anything that could be useful + basics use all year. Also have Alpha GPC which made my adhd brain supercomputer before I got beaten but now doesnt work. Tried before noopept and a lot of racetams, idra21 and some more but with no effect and modafinil before with effect, but mostly anxiety, too much concentrating on one thing and severe insomnia.
I am already pretty sure about Agmatine, Sulbutiamine instead of Benfotiamine (any difference?), not sure of Bromantane on ssri (?), 9-me is no go, maybe NALT (?), Theacrine as Im tired from SSRI all the time and too much coffee makes me axnious, maybe Vinpocetine or Uridine triacetate? centrophenoxine? dihexa?
My treatment from december to now:
I had no idea wth is this, told my psychologist what is happening to me and asking many times if its serious and casually replied that is probably from stress. So I treated it as burnout by resting, then removing original causes and triggers, removing problems from my mind and life, reducing stress to minimum, even leaving my pretty good paid job after 9 yers. But nothing helped besides benzos which made me not feel attacks so much and when I went off after 6 weeks, symptoms came back the same day.
I always said no to ADs but this time I didnt see any other option so I got SSRI citalopram 20, later 30mg now 6 weeks, first weeks were hell of anxiety and tiredness, last 2 weeks they help but effect is enough to keep me attack free only at home, outside flat still almost instant PA + side effects are still bad.
Same with benzos now again for 6 weeks afte break from previous cycle, mostly xanax 1,5-2mg a day, when Im home with no problems I can stay on 0,5mg with no WD. But want to quit asap, Im standing on the edge of little discomfort or living hell WDs. Also it makes me dumb, careless and not caring, but dont have cravings or abuse them, until now there was no other medication in my country :/ Also I already had GABA WDs pretty bad from alcohol many times and from phenibut in february by mistake (3 weeks of 2-3x a week before I had benzos). I would rather skip this opportunity to be on boat walking simulator with scary shadowy guy in my bedroom.
Next week I will make a big changes:
Will to add Buspar in small doses to SSRI, probably 30mg citalopram + 2x7,5mg buspar for long term and propranolol over benzos before I leave flat for panic attacks - I have mostly physical symptoms and over these months my brain has learned to go panic mode when I go around people or noise but im not scared, wanting to hide or anxious, want to go out. Hope this will allow me to relearn the BIOS of my brain and body they wont start panicking as it has learned over months of nonstop attack (january until end of april, just moving on scale 1-10 but never off). Propranolon as beta-blocker should not allow my body to go panic defense mode and mental anxiety I can handle now. My mind is still quite ok, not much depressed or in bad mood, last days even thinking a bit sharper and can handle it but body/brain program are stuck. Hope this will allow me over time to get off SSRI to just Buspar + non addictive anxiety aid as needed or at least switch to SNRI or Wellbutrin as im energetic person but with this SSRI im meeeeeeeh all the time.
As propranolon arrives I will cut benzos to lowest dosage where I wont feel WD, probably 0,5mg/day and switch to Clonazepam (have benzos and can ask doc anytime), keep this dose for 2-3 weeks, taper to 0,35mg, wait and this until i go down around 0,2mg/day. Maybe slower if it will be painful or risk worse WDs when i cut them off.
For quitting benzos I have clonidine (WD reduce, camling, ADHD), pregabalin (GABA substance replacement, anti seizure but addictive), baclofen (GABA substance replacement, anti seizure also addictive)), Etifoxine (nonbenzo anxiolytics, I guess mostly PAWS) and Topiramate (seizure and migraine prevention, WD reduce) and Hydroxyzine (sleepy antihistamine nonaddictive) to get off them asap with no risk seizure and suffering for weeks in terrible WDs. I wont use all the aids together but as needed for current symptoms and not get hooked on none of them as only atarax is safe.
Also finally will get ADHD meds atomoxetin, but as I have no energy, even adhd is not so present and clonidine also helps for adhd. And I have found one super special med you will be interested about- Memantine (bgpharm), do you have experiences about this so called miracle drug? It make you feel softly with unlimited brain power, also it shall lower tolerances to almost all substances and by 30-60% over 7-14 days and then make WDs easier + also helps ADHD. But have no idea when to use it in my plan, I got 2 packs and its cheap so can buy more but dont want to mess with getting off bzs and learning to manage going out. Same question with atomoxetin - when to start? its not stimulant so it should not affect attacks nor benzo WD but idk.
Just in case there would be too much serotonin I will have Cyproheptadine for SS. It should not happen from SSRI+Buspiron but some nootropic or WD med can cause it. And just remembered I shall take some ephedrine/yohimbine if my BP or HB goes too slow from propranolon/clonidine... :/
I will still go for checks to doc and psychiatrist but the medical procedures in my country got stuck in time in year when producers of SSRI/benzos gave some gifts for doctors or politics. So they just give you this combo announcing you it will work (didnt) and you wont get addicted in 3 months of xan (would). Also propranolon is not approved med for anxiety in my county, only bzds and buspirone, but after trying several ADs on you :/
Thank you so much for any knowledge you share with me!

Hi,
I have marked most imporant parts as how long I use each meds in what dose, info of me, my questions, supplements used, nootropics thinking of, new meds for panic disorder treatment, plan to quit benzos, advice about Memantine. If you want, there is whole story and treatment:) Thx I have a lifetime nonmedicated ADHD + OCD (will finally have atomoexin in july after like 8 docs) but mainly severe panic disorder since 12/23 caused by badly burning out and not stopping work + too much stress from all sides, mostly family and workspace/company. It started close to xmas and wanted to finish year and worked until my body completely disabled to it to me but right after it came xmas, which is not my fav time of year ending in keeping me in attacks 24/7. Btw Im 29yo man, 193cm, 90kg, sporting, financial advisor self employed, living alone, used to be really busy all the time, multiple addictions behind me mostly because depression (alcohol),pain (kratom) and stimulants bcs its so addictive with adhd :D But I dont abuse anything since 02/23 when I barely survived WD from forced CT a lot of alcohol every day and I want to be healthy and drugs free!
I am currently getting off xanax and on SSRI, starting my new recovery plan below as previous didnt help enough and asking if you know anything that could help me get my full life back sooner I work as I can/want, mostly 2-6 h/day and only from home, going to multiple types of therapy, investing insane money to get recovered and looking for every possible way. I am open for any tip or advice on nootropic, peptide, maybe even SARMs that could help me get over this. Even if you dont have time or dont want to read all previous treatment and new plan and have idea what could help me, write it please. But I have to be careful with anything interacts with SSRI as I will be also on buspar, I have a safe med for serotonin syndrome if needed.. Also if you see gaps or risks in my meds plan, some ideas, useful info or better ways, I will be glad to know it:) Mostly about Memantine - when to use, in which part of protocol it will be most beneficial or what to expect.
I use/tried almost every useful supplement including adaptogens, herbs, expensive vitamins, mushrooms, gotu kola, NAC, tyrosine, inositol and just anything that could be useful + basics use all year. Also have Alpha GPC which made my adhd brain supercomputer before I got beaten but now doesnt work. Tried before noopept and a lot of racetams, idra21 and some more but with no effect and modafinil before with effect, but mostly anxiety, too much concentrating on one thing and severe insomnia.
I am already pretty sure about Agmatine, Sulbutiamine instead of Benfotiamine (any difference?), not sure of Bromantane on ssri (?), 9-me is no go, maybe NALT (?), Theacrine as Im tired from SSRI all the time and too much coffee makes me axnious, maybe Vinpocetine or Uridine triacetate? centrophenoxine? dihexa?
My treatment from december to now:
I had no idea wth is this, told my psychologist what is happening to me and asking many times if its serious and casually replied that is probably from stress. So I treated it as burnout by resting, then removing original causes and triggers, removing problems from my mind and life, reducing stress to minimum, even leaving my pretty good paid job after 9 yers. But nothing helped besides benzos which made me not feel attacks so much and when I went off after 6 weeks, symptoms came back the same day.
I always said no to ADs but this time I didnt see any other option so I got SSRI citalopram 20, later 30mg now 6 weeks, first weeks were hell of anxiety and tiredness, last 2 weeks they help but effect is enough to keep me attack free only at home, outside flat still almost instant PA + side effects are still bad.
Same with benzos now again for 6 weeks afte break from previous cycle, mostly xanax 1,5-2mg a day, when Im home with no problems I can stay on 0,5mg with no WD. But want to quit asap, Im standing on the edge of little discomfort or living hell WDs. Also it makes me dumb, careless and not caring, but dont have cravings or abuse them, until now there was no other medication in my country :/ Also I already had GABA WDs pretty bad from alcohol many times and from phenibut in february by mistake (3 weeks of 2-3x a week before I had benzos). I would rather skip this opportunity to be on boat walking simulator with scary shadowy guy in my bedroom.
Next week I will make a big changes:
Will to add Buspar in small doses to SSRI, probably 30mg citalopram + 2x7,5mg buspar for long term and propranolol over benzos before I leave flat for panic attacks - I have mostly physical symptoms and over these months my brain has learned to go panic mode when I go around people or noise but im not scared, wanting to hide or anxious, want to go out. Hope this will allow me to relearn the BIOS of my brain and body they wont start panicking as it has learned over months of nonstop attack (january until end of april, just moving on scale 1-10 but never off). Propranolon as beta-blocker should not allow my body to go panic defense mode and mental anxiety I can handle now. My mind is still quite ok, not much depressed or in bad mood, last days even thinking a bit sharper and can handle it but body/brain program are stuck. Hope this will allow me over time to get off SSRI to just Buspar + non addictive anxiety aid as needed or at least switch to SNRI or Wellbutrin as im energetic person but with this SSRI im meeeeeeeh all the time.
As propranolon arrives I will cut benzos to lowest dosage where I wont feel WD, probably 0,5mg/day and switch to Clonazepam (have benzos and can ask doc anytime), keep this dose for 2-3 weeks, taper to 0,35mg, wait and this until i go down around 0,2mg/day. Maybe slower if it will be painful or risk worse WDs when i cut them off.
For quitting benzos I have clonidine (WD reduce, camling, ADHD), pregabalin (GABA substance replacement, anti seizure but addictive), baclofen (GABA substance replacement, anti seizure also addictive)), Etifoxine (nonbenzo anxiolytics, I guess mostly PAWS) and Topiramate (seizure and migraine prevention, WD reduce) and Hydroxyzine (sleepy antihistamine nonaddictive) to get off them asap with no risk seizure and suffering for weeks in terrible WDs. I wont use all the aids together but as needed for current symptoms and not get hooked on none of them as only atarax is safe.
Also finally will get ADHD meds atomoxetin, but as I have no energy, even adhd is not so present and clonidine also helps for adhd. And I have found one super special med you will be interested about- Memantine (bgpharm), do you have experiences about this so called miracle drug? It make you feel softly with unlimited brain power, also it shall lower tolerances to almost all substances and by 30-60% over 7-14 days and then make WDs easier + also helps ADHD. But have no idea when to use it in my plan, I got 2 packs and its cheap so can buy more but dont want to mess with getting off bzs and learning to manage going out. Same question with atomoxetin - when to start? its not stimulant so it should not affect attacks nor benzo WD but idk.
Just in case there would be too much serotonin I will have Cyproheptadine for SS. It should not happen from SSRI+Buspiron but some nootropic or WD med can cause it. And just remembered I shall take some ephedrine/yohimbine if my BP or HB goes too slow from propranolon/clonidine... :/
I will still go for checks to doc and psychiatrist but the medical procedures in my country got stuck in time in year when producers of SSRI/benzos gave some gifts for doctors or politics. So they just give you this combo announcing you it will work (didnt) and you wont get addicted in 3 months of xan (would). Also propranolon is not approved med for anxiety in my county, only bzds and buspirone, but after trying several ADs on you :/
Thank you so much for any knowledge you share with me!