At this point I am documenting for my safety. He did admit to cheating by vaginal penetration and unprotected. He admitted this over the phone and he admitted it over text. I don’t have the recording but I have the text screenshotted. He recently tried backtracking and said it was only oral and that he received ed it from a woman at the gas station out of nowhere and without soliciting after she asked him for a ride (don’t believe that she wasn’t a prostitute but I guess he’s trying to save face). The only problem is I consulted a paramedic from my class that used to work in an std clinic for years and she said trich isn’t spread orally. Trichomoniasis vaginalis does not survive in the rectum or mouth. And this is what I had. He tried to cover his bases by making it seem less. This is not the worst part. Yesterday he talked about getting tested. I have been in communication with his brothers wife. She knows what happened because I told her and told her not to say anything to his brother yet. I found out from her that he was asking his brother to see if he had antibiotics that he could give him. I followed up with him just to see what he would say and he denied looking for treatment and said he would do things the ‘right way’ and get tested first. He’s trying to save face by treating himself and coming back with clean results so he can shift blame to me. I feel like I’m living with an enemy and this is so much worse than I initially thought it was. I never thought he would turn out to be so sinister. Im trying to finish school but I feel like I’m going to have to put so much mental energy into defending myself now and covering my bases. Fuck.

How to Make Pot Brownies: A Step-by-Step Guide

Making pot brownies is a popular and enjoyable way to consume cannabis, combining the delightful experience of eating a sweet treat with the effects of cannabis. Here's a comprehensive guide to help you create delicious and potent pot brownies.

Ingredients

For the Cannabis-Infused Butter (Cannabutter):

• 1 cup (2 sticks) of unsalted butter
• 1 cup of ground cannabis (decarboxylated)

For the Brownies:

• 1 cup of cannabis-infused butter (cannabutter)
• 1 cup of granulated sugar
• 1 cup of packed brown sugar
• 4 large eggs
• 1 teaspoon of vanilla extract
• 1 cup of all-purpose flour
• 1/2 cup of unsweetened cocoa powder
• 1/2 teaspoon of salt
• 1/2 teaspoon of baking powder
• 1 cup of chocolate chips (optional)
• 1/2 cup of chopped nuts (optional)

Tools

• Baking sheet
• Parchment paper
• Saucepan
• Fine mesh strainer or cheesecloth
• Mixing bowls
• Whisk or electric mixer
• 9x13 inch baking pan
• Spatula

Step-by-Step Instructions

1. Decarboxylate Your Cannabis

Decarboxylation is the process of activating the THC in cannabis, making it psychoactive.

1. Preheat the oven: to 240°F (115°C).
2. Prepare the cannabis: Break down the cannabis into small pieces using your hands or a grinder.
3. Spread on a baking sheet: Place the cannabis evenly on a baking sheet lined with parchment paper.
4. Bake: in the preheated oven for about 40 minutes, stirring every 10 minutes to ensure even heating. The cannabis should turn a light brown color.

2. Make the Cannabutter

1. Melt the butter: In a saucepan, melt 1 cup of butter over low heat.
2. Add decarboxylated cannabis: Stir in the decarboxylated cannabis and simmer on low heat for 2-3 hours. Make sure the mixture doesn’t boil.
3. Strain the mixture: Use a fine mesh strainer or cheesecloth to strain the cannabutter into a clean bowl, removing the plant material. Let it cool.

3. Prepare the Brownie Batter

1. Preheat the oven: to 350°F (175°C).
2. Mix sugars and butter: In a large mixing bowl, combine the granulated sugar, brown sugar, and 1 cup of cannabutter. Mix well until creamy.
3. Add eggs and vanilla: Beat in the eggs one at a time, then add the vanilla extract.
4. Combine dry ingredients: In a separate bowl, whisk together the flour, cocoa powder, salt, and baking powder.
5. Mix wet and dry ingredients: Gradually add the dry ingredients to the wet ingredients, mixing until well combined.
6. Optional mix-ins: Fold in the chocolate chips and nuts if desired.

4. Bake the Brownies

1. Prepare the baking pan: Grease a 9x13 inch baking pan or line it with parchment paper.
2. Pour the batter: Spread the brownie batter evenly in the prepared pan.
3. Bake: in the preheated oven for 25-30 minutes, or until a toothpick inserted into the center comes out with a few moist crumbs.
4. Cool: Allow the brownies to cool completely in the pan before cutting them into squares.

Dosage and Consumption

• Dosage: The potency of your pot brownies depends on the strength of your cannabis and the amount used. Start with a small piece and wait at least 1-2 hours to gauge the effects before consuming more.
• Storage: Store pot brownies in an airtight container at room temperature for up to a week or in the refrigerator for longer shelf life.

Tips for a Perfect Batch

1. Consistent Mixing: Ensure all ingredients are well-mixed for even potency.
2. Temperature Control: Avoid high temperatures when making cannabutter to prevent degrading the THC.
3. Patience: Wait for the brownies to cool completely before cutting to prevent them from crumbling.

Enjoy your homemade pot brownies responsibly and remember to label them clearly to avoid accidental consumption. Happy baking!

I was put on Ozempic from May last year to November. In that timespan I dropped 50 pounds (from 250 to 198lbs). I'm a 42 yo pretty active man. Weight lifting...boxing and some cardio and tons of walking. But I do have a binge eating disorder (Night eating syndrome) at night. It's not as bad with Ozempic but I haven't been able to shake off that habit... I've been doing this since I'm like 6 years old.
Despite that I lost 50+ pounds then was put on Rybelsus and my weight crept back up to 225 from November to March this year. Rybelsus was not very effective because of the oral route and i cant seem to be on empty stomach ever because of how much i eat at night.
Was put back on Ozempic (1mg/week) in April and I expected my weight to drop rapidly again. Night food cravings aren't nearly as bad and side effects have been heavy (lots of throwong up but I can handle it).
despite that my weight is frozen at 223lbs and won't budge after a full month on Ozempic max dosage (I know you can have higher semaglutide dosage with wegovy). I'm not sure it's approved in Canada yet
Anyway, could the Ozempic take a couple of months to really take effects? Or should I lower my expectations? Last year the bulk of the weight loss was pretty early into the treatment.
P.s. I know I should get treatment for my eating disorder. I already see a nutritionist and a therapist but it's hardwired into my brain and hard to treat so please stick to the Ozempic talk thank you :)

Journal on the Importance of Treating Drug-Induced Psychosis as a Short-Term Diagnosis

Introduction

Drug-induced psychosis is a severe mental health condition triggered by the consumption of psychoactive substances such as amphetamines, cannabis, cocaine, and hallucinogens. The symptoms can be alarming, characterized by hallucinations, delusions, and impaired cognitive function. Recognizing and treating drug-induced psychosis as a short-term diagnosis is crucial. This journal explores the importance of this approach from clinical, psychological, and social perspectives, including the appropriate use of medications like beta blockers and promethazine, and the rationale for avoiding antipsychotics and depot medications.

Clinical Perspective

1. Differentiation from Chronic Psychotic Disorders: Treating drug-induced psychosis as a short-term diagnosis helps clinicians distinguish it from chronic psychotic disorders like schizophrenia. Drug-induced psychosis typically resolves with the cessation of the substance and appropriate medical intervention, whereas chronic psychotic disorders require long-term management. Accurate differentiation is essential to avoid unnecessary prolonged treatment and the stigma associated with chronic mental illness​ (Cambridge)​.
2. Appropriate Treatment Strategies: Recognizing the short-term nature of drug-induced psychosis allows for tailored treatment strategies. Immediate interventions may include detoxification, supportive care, and the use of specific medications such as beta blockers and promethazine. Beta blockers can help manage the physical symptoms of anxiety and agitation often seen in drug-induced psychosis. Promethazine, an antihistamine with sedative properties, can provide symptomatic relief for anxiety and agitation without the need for antipsychotics.
Use of Beta Blockers:

• Beta blockers, such as propranolol, can reduce symptoms like tachycardia, hypertension, and severe anxiety that often accompany drug-induced psychosis​ (Cambridge)​.
• These medications work by blocking the effects of adrenaline, helping to calm the patient and reduce physiological responses to stress and anxiety.

Use of Promethazine:

• Promethazine is effective in managing agitation and anxiety due to its sedative properties.
• It can promote better sleep and increased appetite, which are often disrupted during psychotic episodes and essential for recovery​ (BMJ Mental Health)​​ (Welcome)​.
  • Improved sleep: Promethazine’s sedative effects help regulate sleep patterns, crucial for cognitive and emotional healing.
  • Enhanced appetite: By alleviating nausea and providing a calming effect, promethazine can stimulate appetite, ensuring the patient maintains adequate nutrition during recovery.

Avoidance of Antipsychotics:

• Antipsychotics should generally be avoided in treating drug-induced psychosis due to their potential for severe side effects, such as extrapyramidal symptoms, metabolic syndrome, and prolonged QT interval​ (Cambridge)​​ (Welcome)​.
• These medications are more appropriate for chronic psychotic disorders and may not be necessary for a condition that is likely to resolve with the cessation of the offending substance and supportive care.

Dangers of Depot Medications:

• Depot antipsychotics are long-acting injectable formulations designed for sustained release over weeks or months. While they are useful for managing chronic psychotic disorders, they are inappropriate for short-term conditions like drug-induced psychosis​ (Cambridge)​.
• Depot medications can cause prolonged side effects, such as extrapyramidal symptoms and tardive dyskinesia, which may persist long after the initial psychotic episode has resolved.
• The long duration of action makes it difficult to adjust dosages based on the patient's immediate needs and response to treatment.
• If adverse reactions occur, the effects of depot medications cannot be quickly reversed, posing significant risks to the patient’s well-being.

3. Monitoring and Follow-up: Acknowledging the transient nature of drug-induced psychosis emphasizes the need for careful monitoring and follow-up. Patients can be closely observed for any recurrent symptoms, ensuring that any underlying psychiatric conditions are promptly identified and treated if they emerge​ (BMJ Mental Health)​.

Psychological Perspective

1. Reducing Patient Anxiety: When patients understand that their psychotic episode is drug-induced and likely short-term, it can alleviate significant anxiety and fear. Knowing that their condition is temporary and treatable can foster a more positive outlook and encourage cooperation with treatment plans.
2. Encouraging Recovery and Rehabilitation: Viewing drug-induced psychosis as a short-term diagnosis supports the patient’s recovery journey. It reinforces the concept that recovery is possible with cessation of drug use and appropriate treatment, which can motivate patients to engage in rehabilitation programs and adopt healthier lifestyles​ (Cambridge)​​ (BMJ Mental Health)​.
3. Addressing Underlying Issues: This approach allows for a focus on addressing the underlying issues that led to substance use. Psychological support can be directed towards coping strategies, stress management, and addressing any co-occurring mental health disorders, which can prevent future episodes of psychosis and promote long-term mental health.

Social Perspective

1. Reducing Stigma: Treating drug-induced psychosis as a short-term diagnosis can help reduce the stigma associated with mental health conditions. By framing it as a temporary state rather than a lifelong condition, patients may face less social judgment and discrimination, facilitating their reintegration into society​ (Cambridge)​​ (BMJ Mental Health)​.
2. Enhancing Social Support: Recognizing the transient nature of drug-induced psychosis can mobilize social support systems more effectively. Families and communities may be more willing to provide support when they understand that the condition is short-term and treatable, enhancing the patient’s support network and improving outcomes.
3. Policy and Resource Allocation: This perspective can influence public health policies and resource allocation. Health systems can prioritize resources for immediate intervention and rehabilitation rather than long-term psychiatric care, ensuring that patients receive the most appropriate and effective treatment for their condition​ (Cambridge)​.

Conclusion

Treating drug-induced psychosis as a short-term diagnosis is crucial for providing accurate, effective, and compassionate care. This approach allows for appropriate clinical management, reduces patient anxiety, and mitigates social stigma. The use of medications like beta blockers and promethazine can manage symptoms effectively without the need for antipsychotics or depot medications, which are better suited for chronic conditions. Promethazine’s benefits in promoting sleep and appetite further support recovery. Emphasizing the transient nature of drug-induced psychosis ensures that patients receive the right treatment at the right time, supporting their recovery and reintegration into society. Adopting this perspective can enhance overall mental health outcomes and contribute to a more understanding and supportive healthcare environment.

References

• Viala, A., Vacheron, M. N., & Ghozlan, A. (2012). Management of drug-induced psychosis: Role of promethazine and beta-blockers. Journal of Psychopharmacology, 26(1), 42-52.
• Cochrane Database of Systematic Reviews. (2016). Haloperidol plus promethazine for psychosis-induced aggression. Retrieved from Cochrane Library​ (Welcome)​.
• National Institute on Drug Abuse (NIDA). (2021). Drug-induced psychosis: Understanding the causes and treatment. Retrieved from NIDA​ (Cambridge)​.

Upped my dose from 100mg, which I’ve been on for five years, 10 if you count the total amount from when I was younger, to 150mg after some new stressors came into my life triggering my OCD and anxiety. Immediately around an hour after taking the increased dose I started to feel better. I’ve felt a whole lot better the last few days but I have spurts of anxiety that last about 10-20 seconds then go back down, it’s like I can just deal with it better. I know it take several weeks to get the full effects, but I’ve come back here to see if anyone has experience with the higher dosages. I know OCD needs higher dosages to treat it.

~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD¹
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.^1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.^6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.

Hello everyone, wanted to share my experience in case anyone is going through the same thing.
Looking back, when I was pregnant I was so sensory overwhelmed all the time, my body was in pain 24/7 and I developed so many skin issues that made me feel like I’m a stranger to myself. TW I attempted taking my own life and the baby’s because I felt like we’re better off not alive Got admitted to the hospital for mental health reasons and put on antidepressants. All while feeling like there’s an alien invading my body. Felt no love, no attachment, nothing but resentment towards the fetus. Then childbirth was horrible too, so many important decisions to make on the spot, masking while in pain so that hospital staff doesn’t treat me poorly. Then the child is out, I hear the first cry, and to my horror I feel… nothing. Her father is excited, cuddling her, can’t take his eyes off of her, while I lay cut open, only caring about myself, wanting to rest and get back to normal.
We’re home with the baby, I try to cuddle her as often as I can, she’s cute, but still I feel no undying love and not bothered by her cries.
I didn’t like it, she deserved a loving mother. So I asked my psychiatrist if I could go on the lowest dose of my antidepressants since they tend to numb me.
Baby is 2 months, I’m on the lowest dosage of AD and BAM! It hits me: all the feels, all the love, all the attachment! It’s all there.
Can I baby talk with her? No, it feels weird. She’s a little human and my buddy, so I talk to her like I would with my friend. Often, when we’re alone together, I forget to talk at all, since she can’t respond I just have conversations in my head like I usually do.
Since I don’t have experience with babies I expect her to act like adults do, so sometimes I feel like her actions are personal and aimed to hurt me, but I remind myself that “she just a lil baby” and get over it.
Anything to do with milking myself is abysmal. I just know that from science perspective breast milk is best so I persevere.
My interest (not sure if it’s special interest) has always been learning and science so luckily that’s a lot to learn about babies and parenting that keeps me occupied and stimulated in a good way.
In conclusion: this is my personal experience and may be different for others but I would still want to have a child, despite all the hurdles and downsides.
Also wanted to add that I mask and pretend to be a normal parent with people, say all the stuff they want to hear about parenting and babies so that part never ends I guess… My close friends are always entertained (and sometimes concerned) with how I act and talk with my child, they say it’s very atypical (haha, get it?)

hi all
I have been taking prednisalone for about 7-8 months now at what I would call low doses. Its been helping me drastically but recently I have started feeling unwell, dizziness and stomach pain, although stomach pain is why I took them in the first place. My dosage has been, 2,5mg for 4 days straight and then I would stop for 6 days and start the cycle again. But for last 3 month I have been doing 2.5mg / 5mg/2.5mg and then stop on day 4 and this worked well, sometimes I would do 2.5mg/5mg/5mg/2.5mg and then stop for 6 days.
Its complicated to explain why but I have been self treating myself outside any doctors advice, I have an unrecognised immune condition and suspect MCAS but in the UK this diagnosis is not recognised. I seem to respond to mast cell stabilisers and tried ketotifen and doxcepin , both help but are not enough to help my base line symptoms much which are still severe and the two most drastic ones are severe food intolerance on the border of not being to eat much and pain. Biological therapy are a no go because of unrecognised or no diagnosis. After reading extensively about this topic, I tried prednisolone and its transformed my life and knew the risk of adrenal insufficiency, was really hopping that my low dose and on and off would minimise my risk. on prednisolone I can eat more foods without reacting and feel much better, can even go for walks without pain dropping me and gained my mobility back.
I want to go to my doctor to ask for a adrenal test but I am really on my own with this one.
really I want to know what symptoms you experienced that made you see doctor and what dosage , and what you were taking and how long?
thank you

So one of my cousins owns a Pharamcy with her husband and they are doing pretty well at it for their age. I drove down there today to pick up one of my prescriptions for my ADHD because I feel like my adhd is just going crazy right now. I got it for 75$ since it was generic and not brand. Like I had said before I went through something last year of Aug 2023 and it was pretty traumatic and I'm pretty sure it has to deal with my ADHD. I just looked at my pills and they were red. My 20mg ones are yellow so I don't know if that is the main dosage that everyone takes whenever they treat their ADHD. I know my meds are not the cure for ADHD but at least they help lessen my symptoms to cope with it better. Anyways, this post is just me wondering that if they are always a different color with the different mg.
Edit: my new pills are 10mg also thank you for blowing this up!!

I was given Chlamydia and Mycoplasma by my bf. He had no idea he had anything and neither did I for almost a year. It was a freak incident and he’s learned his lesson to never endanger someone again by not getting tested after being with someone. We both got squared away. Several months ago now. I thought. I’ve had lab work done to verify #1. I even had an STD and then #2. Went back after medicine to insure everything is gone. Let me read off my final lab results after medication. No Chlamydia, Trich, Mycoplasma Genitalium, Mycoplasma Hominis, Ureaplasma, gonorrhea, Candida, Gardnerella, or BV. I don’t have anything. But look at these other lab results. My WBC is 11.8 which is very high. My Neutrophils were 7.8 which is also out of range. High white blood count indicates infection right? Now for my symptoms. This is gonna be TMI but we’re all grown and I just need y’all to know I’m not crazy. I feel like my doctor thinks I am which is why I’m trying so hard to explain this perfectly because when I go to her I just get shut down. Maybe you guys can push me in the right direction. Anyway, the smell is 110% different. It’s not fishy like BV but it’s strong even a couple hours after I shower and I HAVE NEVER HAD ISSUES CLEANING MYSELF FYI. It’s not a hygiene issue. This is all new stuff. And there’s a different taste too. Not only did I notice but so did my partner. He’s never tasted it on me before even when we unknowingly had the STDs so it’s something else. I told you TMI. Then my discharge. It’s sometimes clear but mainly really milky white and sometimes has tiny traces of blood in it. In all bathroom lighting it looks yellowish/greenish but when you shine a flash light on it it’s just white/cloudy and sometimes has little amount of blood. And I will say the last several times I’ve gone when they do the pee stick thing to check all your levels and stuff there was blood in my urine. They’ve told me that several times but never treat me for anything. I don’t have any constant pelvic pain. I have no fevers. My question is that since I had STDs for so long without knowing, could they have wreaked havoc elsewhere in my body? Could I have a UTI with no pain? Cystitis?? Cervical cancer?! I DONT KNOW. What is happening to my body?!! I scheduled an appointment AGAIN with my doctor to try to figure this out. Is there anything you recommend I tell her to look for? I am beyond stressed out about this and so uncomfortable. I just want my regular sex life and the little amount of confidence I did have. I feel like I’m going crazy because I KNOW something is wrong and they can’t find anything. Or they aren’t looking in the right place but I don’t know where to tell them to look. Kinda why I’m not a doctor. Please help me. I’m telling you something is wrong

Before considering buying steroids, it's essential to understand the potential risks, legal implications, and health considerations associated with their use. Here are some important factors to consider:

1. **Legal Status**: In many countries, steroids are controlled substances and can only be obtained with a prescription for medical purposes. Purchasing steroids without a prescription or from illegal sources can result in legal consequences.
   
2. **Health Risks**: Steroids can have serious side effects, including liver damage, cardiovascular issues, hormonal imbalances, infertility, and psychiatric effects such as mood swings and aggression. Long-term use can lead to dependency and addiction.
   
3. **Purpose**: Understand why you want to use steroids. Are you looking to enhance athletic performance, improve muscle mass, or treat a medical condition under the supervision of a healthcare professional? Using steroids for non-medical purposes is risky and can have serious consequences.
   
4. **Quality and Source**: If you're obtaining steroids, ensure that they are from a reputable source and are of pharmaceutical grade. Underground labs and black market products may be contaminated or of poor quality, posing additional health risks.
   
5. **Dosage and Administration**: Proper dosage and administration are crucial for minimizing health risks. If you're unsure about how to use steroids safely, consult with a qualified healthcare professional or endocrinologist.
   
6. **Potential Interactions**: Steroids can interact with other medications and supplements, potentially causing adverse effects. Make sure to disclose all medications and supplements you are taking to your healthcare provider before starting steroid use.
   
7. **Monitoring and Follow-up**: Regular monitoring by a healthcare provider is essential while using steroids to monitor for potential side effects and adjust treatment as necessary.
   
8. **Alternative Options**: Consider alternative strategies for achieving your goals, such as proper nutrition, training, and supplementation with legal and safer substances.
   
9. **Personal Health**: Consider your own health status and any pre-existing medical conditions before using steroids. Certain medical conditions may be exacerbated by steroid use.
   
10. **Long-Term Implications**: Think about the long-term implications of steroid use on your health, including potential effects on fertility, hormonal balance, and overall well-being.
    

Adderall contains two mixtures: amphetamine and dextroamphetamine. Adderall is the commonly used brand name to treat ADHD, OCD, and narcolepsy. Adderall is a controlled substance, and although it is on the verge of being mistakenly thought of as an opioid, it is a stimulant and not an opioid. Opioids are depressants1, so narcotics are used as painkillers and to practically numb a person from any pain or discomfort. Understandably, Adderall is not a narcotic. HOW CAN people be so ignorant. That old wench “I used to be a pharmacy technician..” ohhh. K.
Schedule II
Schedule II drugs, substances, or chemicals are defined as drugs with a high potential for abuse, with use potentially leading to severe psychological or physical dependence. These drugs are also considered dangerous. Some examples of Schedule II drugs are: combination products with less than 15 milligrams of hydrocodone per dosage unit (Vicodin), cocaine, methamphetamine, methadone, hydromorphone (Dilaudid), meperidine (Demerol), oxycodone (OxyContin), fentanyl, Dexedrine, Adderall, and Ritalin

I was given Chlamydia and Mycoplasma by my bf. He had no idea he had anything and neither did I for almost a year. We both got squared away. I thought. I’ve had lab work done to verify I

1. Had an STD and then

2. Went back after medicine to insure everything is gone. Let me read off my lab results.

No Chlamydia, Trich, Mycoplasma Genitalium, Mycoplasma Hominis, Ureaplasma, gonorrhea, Candida, Gardnerella, or BV. I don’t have anything. But look at these other lab results.
My WBC is 11.8 which is very high. My Neutrophils were 7.8 which is also out of range. High white blood count indicates infection right? Now for my symptoms. This is gonna be TMI but we’re all grown. I feel like my doctor thinks Im crazy which is why I’m trying so hard to explain this perfectly because when I go to her I just get shut down. Maybe you guys can push me in the right direction.
Anyway, the smell is 110% different. It’s not fishy like BV but it’s strong even a couple hours after I shower and I HAVE NEVER HAD ISSUES CLEANING MYSELF FYI. This is all new stuff. And there’s a different taste too. Not only did I notice but so did my partner. He’s never tasted it on me before even when we unknowingly had the STDs so it’s something else. I told you TMI.
Then my discharge. It’s sometimes clear but mainly really milky white and sometimes has tiny traces of blood in it. In all bathroom lighting it looks rellowish/greenish but when you shine a flash light on it it’s just white with blood. And I will say the last several times I’ve gone when they do the pee stick thing to check all your levels and stuff there was blood in my urine. They’ve told me that several times but never treat me for anything.
I don’t have any constant pelvic pain. I have no fevers. My question is that since I had STDs for so long without knowing, could they have teamed havoc elsewhere in my body? Could I have a UTI with no pain? What is happening to my body?!!
I scheduled an appointment AGAIN with my doctor to try to figure this out. Is there anything you recommend I tell her to look for? I am beyond stressed out about this and so uncomfortable. I just want my regular sex life and the little amount of confidence I did have.
I feel like I’m going crazy because I KNOW something is wrong and they can’t find anything. Or they aren’t looking in the right place but I don’t know where to tell them to look. Kinda why I’m not a doctor. Please help me.

Are you struggling with persistent redness, visible blood vessels, or uncomfortable bumps on your face? Rosacea is a common but often distressing skin condition that affects many individuals. Rosacea Treatment in Borivali, Mumbai at B.A.E Skin Clinic, Dr. Krupa Modi offers expert care and tailored treatment plans to help manage and alleviate the symptoms of rosacea, restoring your skin’s health and confidence.

Understanding Rosacea

Rosacea is a chronic inflammatory skin condition primarily affecting the face, causing redness, swelling, and sometimes acne-like breakouts. Common triggers include:

• Sun exposure
• Stress
• Hot or cold weather
• Spicy foods
• Alcohol
• Certain skincare products

Comprehensive Rosacea Care

At B.A.E Skin Clinic, Dr. Krupa Modi combines her extensive dermatological expertise with a compassionate approach to deliver the best care for rosacea patients. Our comprehensive treatment plans are customized to each patient's unique skin type and condition, ensuring effective and lasting results.

Our Rosacea Treatment Services

1. Personalized Skin Assessment:
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   • Advice on lifestyle modifications to avoid rosacea triggers and flare-ups.
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Don’t let rosacea control your life. Take the first step towards clearer, healthier skin by scheduling a consultation with Dr. Krupa Modi at B.A.E Skin Clinic. Our dedicated team is here to support you on your journey to radiant skin.
Experience the difference in professional, compassionate rosacea treatment at B.A.E Skin Clinic. Your path to beautiful, clear skin starts here! For more information call us at +91 86573 55999 or visit us at https://baeskinclinic.com/
Rosacea Treatment in Borivali, Mumbai B.A.E Skin Clinic Dr. Krupa Modi

1. **Manufacturing Process**:
Pharmaceutical Grade Steroids: These are manufactured by licensed pharmaceutical companies that adhere to strict regulations and quality control standards set by government agencies such as the FDA (Food and Drug Administration) in the United States or the EMA (European Medicines Agency) in Europe. The manufacturing facilities are subject to regular inspections to ensure compliance with Good Manufacturing Practices (GMP).
UGL Grade Steroids: These are produced by underground laboratories, which operate illegally and without regulatory oversight. The manufacturing processes and conditions of UGLs vary widely and are not subject to the same stringent quality control measures as pharmaceutical-grade products. Consequently, the purity, potency, and sterility of UGL steroids may be questionable.
2. **Quality Control**:
Pharmaceutical Grade Steroids: These undergo rigorous testing at various stages of the manufacturing process to ensure purity, potency, and sterility. Pharmaceutical companies employ qualified chemists and pharmacologists to conduct analytical testing and quality assurance protocols.
UGL Grade Steroids: Quality control in UGLs is often lacking or nonexistent. There is no guarantee of the accuracy of labeling, the absence of contaminants, or the actual dosage of the steroid. Users of UGL steroids may be at risk of receiving products that are under-dosed, contaminated, or mislabeled.
3. **Legality**:
Pharmaceutical Grade Steroids: These are legally produced and distributed under the supervision of regulatory authorities. They are prescribed by healthcare professionals for legitimate medical purposes such as hormone replacement therapy (HRT) or treating certain medical conditions.
UGL Grade Steroids: The production, distribution, and possession of UGL steroids are illegal in most countries. Using UGL steroids for non-medical purposes is considered a violation of drug laws and can result in legal consequences.
4. **Availability and Cost**:
Pharmaceutical Grade Steroids: These are typically available through licensed healthcare providers with a valid prescription. They are more expensive than UGL steroids due to the higher manufacturing standards, regulatory compliance costs, and quality assurance measures.
UGL Grade Steroids: These are often more readily available through underground channels such as black market suppliers or online sources. They are generally cheaper than pharmaceutical-grade steroids but come with greater risks of impurity and legal repercussions.
In summary, Pharmaceutical Grade Steroids are produced by legitimate pharmaceutical companies with strict quality control standards and regulatory oversight, whereas UGL Grade Steroids are manufactured clandestinely without adherence to regulations or quality control measures. Users of UGL steroids should be aware of the potential risks associated with their use, including impurities, inaccuracies in dosage, and legal consequences.

Anavar, a popular anabolic steroid, has garnered attention for its numerous benefits, both in the realm of fitness and medicine. While its primary use is in treating medical conditions like muscle wasting and promoting weight gain after surgery, Anavar also holds appeal for athletes and fitness enthusiasts seeking to elevate their performance and physique. Here are some key benefits of Anavar:

1. Muscle Growth and Strength: Anavar is renowned for its ability to promote lean muscle mass gains. It works by increasing protein synthesis within muscle cells, facilitating muscle repair and growth. This makes it a valuable tool for athletes aiming to enhance their strength and power.
2. Fat Loss: Unlike some other steroids, Anavar has a unique ability to aid in fat loss while preserving lean muscle tissue. It enhances metabolic rate and promotes a more defined, toned physique. For individuals undergoing cutting cycles or looking to shed excess body fat, Anavar can be a valuable ally.
3. Improved Endurance and Performance: Anavar's effects extend beyond muscle growth and fat loss. It can significantly increase endurance and stamina, allowing users to train harder and longer. This makes it particularly beneficial for athletes involved in endurance sports or those seeking to push their limits during intense workouts.
4. Enhanced Recovery: One of the often-overlooked benefits of Anavar is its capacity to accelerate recovery between workouts or after injuries. By reducing muscle damage and inflammation, it enables users to bounce back quicker, ensuring they can maintain consistent training and avoid setbacks.
5. Low Androgenic Side Effects: Compared to many other steroids, Anavar has lower androgenic properties, meaning it is less likely to cause virilization in women or other androgenic side effects such as acne and hair loss in both genders. This makes it a safer option for many users, particularly women.
6. Medical Benefits: Beyond its performance-enhancing effects, Anavar is prescribed medically to treat a variety of conditions, including muscle wasting diseases like HIV/AIDS-related wasting syndrome, severe burns, and even osteoporosis. It can also aid in recovery post-surgery by promoting weight gain and muscle repair.

While Anavar offers numerous benefits, it's essential to use it responsibly and under the guidance of a healthcare professional. Like any steroid, it can carry risks, including liver toxicity and hormonal imbalances. Therefore, individuals considering Anavar should weigh its potential benefits against potential risks and ensure they adhere to recommended dosages and cycles.
In conclusion, Anavar is a versatile compound with the potential to enhance physical performance, promote muscle growth, and improve overall well-being. Whether used for medical purposes or as a performance enhancer, its benefits are undeniable, making it a valuable tool for individuals striving to achieve their fitness goals.

Major depressive illness, anxiety disorders, chronic pain, and addiction are all treated with antidepressant medicines.
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So I am having a hard time processing all of this. I have always been anxious my whole life. Always considered it someone if a blessing and a curse. Great grades, high achiever, disciplined, aware, clean, well put together athletics, etc. Always “powered through got my stuff done child and into my adult life. Yes the anxiety always there but I guess I always just thought this is how I’m wired…or perhaps thought the way I felt was “normal”
I was always social, personable, a partier and as I got older alcohol became a pretty damn good way to unwind or relax or tame the anxiety. Alcohol consumption became a big part of my life and I think a solution to many of my ills. Extremely functional then at some point dependence happened. More extreme anxiety to the point of no longer functioning withdrawals etc. Awful. 2017
Needed to make dramatic changes. Many different docs, pyschs, functional medicine docs. Need to treat the anxiety and certainly booze is not the answer. First tried to address the anxiety with supplements. Time and time again is it working, is it not, how do I feel? How the hell am I supposed to feel, I don’t know. Do I even know what it feels like to feel “normal or good”
Sobriety, therapy, dbt, cbt, address trauma, EMDR, relationship issues, family issues, rehabs, iop’s, meditation, hot yoga, AA/12 step, exercise/super active —everything under the sun and a lot of money spent to do it.
And yes during some of this I wasn’t sober and consistency wasn’t always there some I was but always felt like anxiety was always there and all that goes with it. Genuinely trying but never really felt relief.
Functional medicine doc finally prescribed SSRI (Lexapro) 2019. Was always fearful due to sexual side effects. Or maybe that was my own excuse I don’t know. Either way I didn’t and don’t have any. Still to this day I question whether the Lexapro, Buspar, on propanalol too and not for blood pressure. Is any of it working? How the hell am I supposed to feel?
In 2022, I relocated back to my home state, new job in corporate America (high stress, expectations, big job, etc). Family, friends, more of it all, my people. Sober and in 2023 I switched my psych doc largely due to move. I have always been anxious person I don’t know? For the first time ever, in all of this, years!!!! My new doctor asks me. Have you ever been treated or tested for ADHD? I was like what? What do you mean? There’s no way….ps, my father is an internal medicine doc for 40 years and never was this even brought up.
My new doctor does the test and she’s like yeah. I believe you have adhd and think it may be driving the anxiety. I was kinda flabbergasted. She put me on adderall. Wait, a stimulant for my anxiety?
Anyway and know this is a lot! We worked on the dosage, I took detailed notes, I feel like we are where we need to be….the results in almost every single way have been life changing in almost every aspect. The weight off my shoulders and of course time will tell and need to continue all the rest that also helps.
So now comes my question….and perhaps a little hard to answer. If this had been figured out earlier would things have been different in my life? I went through a lot and a lot of my own making. It was very, very, hard.
Why did it take so long, why did doctors never bring this up?
I am immensely grateful to be where I am now. It feels so great. But I truly wish I could’ve gotten here many years ago…
🙏🙏🙏 thank you for your time, thoughts, insight!

Good Day!
About 12 hours ago, I was bitten by my pup on the finger, at 12 AM, it was small like a knife or a paper cut. It bled but I cleaned it right away with water and alcohol.
My pup was born inside of our house, is almost 5 months old, has not gone outside of our house and came in contact with other dogs or animals. He was recently dewormed 2 weeks ago, (and only got dewormed again and his first shot of anti-rabies just earlier, about 3 hours ago). He’s very normal and healthy, spoiled even as he stays indoors.
However when he bit me he still didn’t have any anti-rabies shot. I was quickly brought to the hospital at around 12:30 AM or so, it’s a hospital nearby.
It was a category 3 animal bite because it bled yes and the nurses followed the protocol treatment, making it day 0.
I took these shots in 4 of my limbs;

1. Anti-Rabies shot
2. Erig Vaccine with proper dosage based on my weight.
3. Two Tetanus Shots

I will be coming back once a week for for more anti-rabies shots then will come back in 6 months for another shot (I forgot what type it was, was it a booster?)
I got back home around 2 AM.
All that I ask now is if you believe that I will not likely get rabies now that I was treated as fast a possible? I’m just very anxious and I am terrified of the symptoms.
I actually almost contracted rabies again before, it was a decade ago, I was around 9 or 10 years old. I was scratched by an actual stray kitten I picked up, it clunged on my wrists too hard and slid its claws down. The wound was bleeding so much I still remembered it vividly.
I was brought to the nearest Animal Bite center I had to take 10 shots, once a week, I of course don’t remember what kinds of shots they were. I didn’t take rabies before seriously as a kid since I was innocent and unaware of how lethal it was, all I knew is that I had to visit the doctor once a week for those shots. I couldn’t believe I went through a much terrible wound before as a kid, unlike the one I got earlier, a small bite from a pup.
Am I completely safe now?