2024.05.19 09:20 zlaxy On this day 116 years ago, Nikolay Pilchikov, a scientist-physicist, developer of radio-controlled devices, died in Kharkov from a shot in the heart
On this day 116 years ago in Kharkov Nikolay Dmitrievich Pilchikov – scientist-physicist, inventor in the field of radio engineering, author of works on optics, terrestrial magnetism, electrical and radio engineering, radioactivity, X-rays, electrochemistry, geophysics, meteorology – was shot in the heart. submitted by zlaxy to ThisDayInHistory [link] [comments] At about seven o’clock in the morning of 6 May 1908, a shot rang out in a ward of an expensive Kharkov hospital. Breaking open the door locked from the inside, the doctors saw its only patient – it seemed that his life had been cut short in his sleep. The man was lying in his bunk, as if he hadn’t woken up yet. And if not for the bloodstain on his chest, no one would have realised the tragedy. A revolver lay on the tea-table beside the bed. It was from this revolver that the bullet that had pierced the scientist’s heart had been fired. Could a man who was undergoing medical treatment have carefully placed the gun beside his tea glass and folded his arms across his chest after shooting himself at point-blank range? Nevertheless, the “cadaver book” records ruled the death a suicide. For some reason forensic experts did not do dactyloscopy – the investigation was not puzzled by fingerprints on the black “bulldog”, which became the murder weapon. And the authoritative professor Nikolai Bokarius, whose name now bears the local Institute of Forensic Medicine, even described Pilchikova’s case in a textbook for lawyers and doctors as an example of temporary purposeful capacity of suicides with fatal gunshot wounds in the heart area. At that, the luminary recommended to take into account not only anatomical features of the injury, but also the functional state of the central nervous system. The picture was completed by the conclusion of pathologists, who found in the killed after the autopsy of the corpse modifications in the structure of the brain. A purely “police” justification for not considering the murder version was the fact that the incident took place in a locked room on the first floor (as if this could be an obstacle to unauthorised entry). And a week after the scientist’s death, on 13 May 1908, the head of the police department received a report from the head of the Kharkov security service about the unreliability of the “extreme leftist” Professor Pilchikov, who was known for his active participation in “criminal agitation activities of engineering students”. This was confirmed by a search of the scientist’s house, during which propaganda literature from the period of the first Russian revolution of 1905 was found. What was Professor Pilchikov doing before he was “worked out” by the police? The scientific fate of Nikolai Dmitrievich was as unusual as his death was mysterious and the fate of outstanding discoveries inexplicable. The scientist, whose life was cut short at the age of 51, was not only a physicist, but also a lyricist: he was no less talented in composing poetry, painting pictures and playing the violin. But he considered his life’s work to be his scientific career, which was unusually successful. The son of a public and cultural figure, who was a friend of Taras Shevchenko, was born on 9 May 1857 in Poltava, and already during his studies in gymnasium showed remarkable abilities in exact sciences. Entering the Faculty of Physics and Mathematics of Kharkiv University, he experimented in new at that time experiments in the field of sound recording, while still a student invented an electric phonograph. After graduation, the graduate was left to work at the Department of Physics. His first scientific monograph was devoted to optical analysis. Later the scientist made a number of discoveries on the topics of scattered light polarisation and atmospheric ionisation, atmospheric electricity and geomagnetism, radioactivity and X-rays. Pilchikov was awarded the Silver Medal from the Russian Geographical Society for a series of studies of the Kursk Magnetic Anomaly, during which iron ore deposits near Prokhorovka were predicted. After defending his thesis at the University of St. Petersburg, the master of physics was appointed privat-docent of the Kharkov University, and two years later he went to practice at a magnetic observatory in Paris, where he discovered flaws in the design of the seismograph and offered his mentors a way to correct them. Soon the young professor of Kharkov University becomes famous outside Russia, becoming a regular at international scientific conferences and a member of the Toulouse Academy of Sciences. Nikolay Pilchikov returned to Kharkov as a university professor, where he created a meteorological station that still exists today. To study the upper atmosphere, the professor developed a stratostat and then a high-altitude spacesuit to equip the pilot. The atmospheric optics researcher created his own seismograph and designed equipment to determine magnetic pressure. Having moved for some time to Odessa (to work at the Imperial Novorossiysk University), in 1894 the scientist invented an original lamp for the study of X-rays, called “Pilchikov’s focus tube”. The optical and galvanic version of the study of electrolysis developed by him made it possible to obtain images on metal plates – so the inventor became the author of electrophotography or photogalvanography. And on 25 March 1898, Nikolai Pilchikov demonstrated for the first time a device working with radio waves of a certain length and rejecting interference. During his experiments in Odessa he lit a lighthouse with the help of radio waves and moved a railway semaphore, blew up a yacht and made a cannon fire. The scientist characterised his contribution to radio physics as follows: while Popov and Marconi were looking for a way to transmit a signal over the greatest possible distance, he was solving the problem of cutting off wireless power transmission from extraneous electrical waves. Thus appeared the first device with a protector – a security filter, allowing only the waves addressed to it to reach the mechanism and protecting the equipment from atmospheric and radio interference. The scientist not only designed and manufactured different types of the first protectors, but also tested them in practice. With the help of his revolutionary device, Professor Pilchikov made it possible to create radio-controlled mine boats that could sink enemy ships without a crew and fire on enemy targets. In proposing the idea to the Russian military, the inventor characterised it as a way of detonating objects at a considerable distance without cables or other visible communication. Applying for financial assistance from the military department, Pilchikov planned to spend 15,000 roubles on laboratory equipment, manufacture of devices and their testing with the support of the Sevastopol naval forces. For his part, the scientist undertook to keep the know-how in strict secrecy and not to publish any information about the development in scientific literature. As a result, this circumstance may have contributed to the fact that the scientist’s works disappeared and he himself may have been eliminated. Military engineers discussed the professor’s petition for research funds with reference to foreign experience. Specialists compared Pilchikov’s achievements with the developments of foreign scientists experimenting with wireless telegraph, to whom the authorities did not refuse anything. For example, Preece was authorised for experiments by the postal department of England, Marconi obtained in 1897 large sums of money from the naval department of Italy, and the Berlin scientist Slaby received aeronautical parks, watercraft and troops of the Potsdam garrison from the Emperor of Germany. Pilchikov, on the other hand, had a much more extensive programme and was naturally expected to produce the most ambitious results. On his return to Kharkov in 1902, the professor continued his research in the best-equipped physical laboratory of those times, the local University of Technology. He was also allocated a ship “Dnestr” and funds for marine experiments. On the ship in 1903 the scientist equipped a receiving radio station, and on the Chersonese lighthouse – transmitting. Alas, neither the scheme of those protectors, nor the content of the experiments, nor their further fate are known today. In the archives we found only information about a letter of gratitude to Professor Pilchikov from the Commander of the Pacific Fleet. It was dated the beginning of September 1904. It is clear that in the midst of the war with Japan secret military developments could be of interest to both belligerents. Moreover, other external enemies were also interested in preventing Russia’s military advantage. Professor Pilchikov’s research competed with American experiments in the Maritime Ministry under Tesla, who was also working on the task of wireless control of a minelayer from the shore. This is a case in science when “an idea is in the air” and the same discovery is independently made by scientists at different ends of the world. It is believed that the first radio-controlled telemechanical system in the world was developed by Nikola Tesla – he patented and presented an unprecedented ship model in the summer of 1898, but came to the discovery the day before, in spring. And “Russian Tesla” Nikolai Pilchikov tested a similar invention in March of the same year, which was reported in a note in the “Odessa Review”, which for some reason remained unnoticed by the scientific community. The “two Nicholas” had a lot in common, despite the fact that they lived and created on different continents. Scientists were almost the same age. Both had no family – neither wives nor close relatives. Both were undividedly attracted to physical science – the mysteries of radioactivity, X-rays and lightning. But to Pilchikov did not appear one day George Westinghouse with a million dollars for four dozen patents. And an understanding friend, as Tesla had in the person of Katharine Johnson, next to Nikolay Dmitrievich was not there either… Being left without further state support, Pilchikov could not complete the work on his wireless protector. In 1905 he left to observe the solar eclipse in Algeria, from where he returned with failing health. Ill-health was aggravated by an acute feeling of loneliness. 1908 was a fateful year in the fate of the scientist. It was the best time of the year, the beginning of May, a time of intoxication with life and romantic dreams. But for Pilchikov, the “delight of nature” had no inspiring meaning: five days before his own birthday, he went to a psychoneurological clinic. And it happened under very mysterious circumstances. According to police reports, the owner of a private hospital and a well-known doctor I. Y. Platonov received a call from an unknown man on 3 May with a request to hospitalise Nikolai Dmitrievich Pilchikov. It was asked to prepare a separate room where the patient would be alone. When the professor appeared in the clinic, the doctors saw nothing critical in his condition. He was elegantly dressed, and in his hands held a suitcase with papers. Two days later, a shot rang out in the ward, and the papers were gone. Not a single piece of his war work was found among his household belongings. The blueprints of inventions of world importance, which the scientist had not even had time to patent, disappeared. Wasn’t the murder then the final fat point in the planned operation? And didn’t the inventor-physicist take with him to the ward what the special services hunting for his military developments were tracking down? Perhaps it was in the hospital that Nikolai Pilchikov, who had a premonition of trouble, tried to hide from his threatening pursuers? Or maybe they put him there so that it would be easier to realise what they had planned? And who were these mysterious killers?.. We will probably never get answers to these questions. But it is known how the brilliant ideas of the tragically departed scientist were put into practice. In 1913, the first radio-controlled aeroplane took to the skies. Four years later, a German boat controlled from a plane blew up the quay in the English harbour of Newport. In the same year, 1917, a German ship was damaged by a British minelayer guided from a radio-controlled aeroplane. In 1925 the first mine without wires appeared. And in 1943 the Soviet troops destroyed the Nazi headquarters with General von Braun in Kharkov occupied by the enemy by controlled explosion from Voronezh. Radio warfare has long been supplemented by radio defence, where the first role is played by devices like Pilchikov’s protectors. Thanks to radio defence, in 1944 the British were invulnerable to German fighters in the Libyan desert. Radio locks of increased complexity are used in satellite navigation and launching systems for space and military rockets. And all responsible radio electronic equipment is protected from interference by modern devices working on the principle of Professor Pilchikov’s protector – the “Russian Tesla”, who became a hindrance to someone himself… Source: Vyacheslav Kapreljants |
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2024.05.18 23:04 Darth11Chaoz [German] Can anyone explain why "aus" doesn't go to the end of the sentence? I'm very confused about this verb in particular
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2024.05.18 21:15 SanderSo47 Directors at the Box Office: Clint Eastwood (Part 1)
https://preview.redd.it/m07tmkxgi81d1.jpg?width=2048&format=pjpg&auto=webp&s=a069dd209bca819edad29814e0bbd2b76eaa50db submitted by SanderSo47 to boxoffice [link] [comments] As Reddit doesn't allow posts to exceed 40,000 characters, Eastwood's edition had to be split into two parts because his whole career cannot be ignored. The second part will be posted tomorrow.Here's a new edition of "Directors at the Box Office", which seeks to explore the directors' trajectory at the box office and analyze their hits and bombs. I already talked about a few, and as I promised, it's Clint Eastwood's turn.Eastwood was a troublemaker at school, and he had a bunch of odd jobs such as lifeguard, paper carrier, grocery clerk, forest firefighter, and golf caddy. In 1951, he was drafted into the United States Army during the Korean War and was discharged two years later. Through this, he got into contact with a Hollywood representative, who got him into acting classes and started his acting career. He got his start by starring in the hit show Rawhide, but he said he was exhausted by the experience. This caught the attention of some film producers and he decided to act in films directed by the then-unknown Sergio Leone. His career was on the rise, and then he got the chance to make his directorial debut. From a box office perspective, how reliable was he to deliver a box office hit? That's the point of this post. To analyze his career. It should be noted that as he started his career in the 1970s, some of the domestic grosses here will be adjusted by inflation. The table with his highest grossing films, however, will be left in its unadjusted form, as the worldwide grosses are more difficult to adjust.Play Misty for Me (1971)"The scream you hear may be your own!"His directorial debut. It stars Eastwood, Jessica Walter and Donna Mills, and follows a radio disc jockey being stalked by an obsessed female fan. Before his colleague Irving Leonard died, he and Eastwood had discussed the idea of producing a film that was to give Eastwood the artistic control he desired, and his debut as a director. Eastwood said he was ready, "I stored away all the mistakes I made and saved up all the good things I learned, and now I know enough to control my own projects and get what I want out of actors." The film was a huge success for Eastwood, and it also received positive reviews. So far, his directorial career was off to a great start.
High Plains Drifter (1973)"They'd never forget the day he drifted into town."His second film. The film stars Eastwood, Verna Bloom and Mariana Hill, and follows a mysterious stranger who metes out justice in a corrupt frontier mining town. Eastwood reportedly liked the offbeat quality of the film's original nine-page proposal and approached Universal with the idea of directing it, which would make it his first directed Western. The screenplay was inspired by the real-life murder of Kitty Genovese in Queens in 1964, which eyewitnesses reportedly stood by and watched. Holes in the plot were filled in with black humor and allegory, influenced by Sergio Leone. It was well received, and the film even surpassed Play Misty for Me at the box office. Eastwood was just going up.
Breezy (1973)"Her name is Breezy."His third film. It stars William Holden and Kay Lenz, and follows the relationship between a middle-aged real estate agent and a young hitchhiker. This was his first directed film without starring on it. And his lack of presence certainly hurt the film; it received mixed reviews and flopped at the box office.
The Eiger Sanction (1975)"His lifeline, held by the assassin he hunted."His fourth film. Based on the novel by Trevanian, the film stars Eastwood, George Kennedy, Vonetta McGee, and Jack Cassidy. It follows Jonathan Hemlock, an art history professor, mountain climber, and former assassin once employed by a secret government agency, who is blackmailed into returning to his deadly profession for one last mission. The film received mixed reactions for its writing, and it wasn't a box office success either.
The Outlaw Josey Wales (1976)"An army of one."His fifth film. Based on the novel Gone to Texas by Forrest Carter, it stars Eastwood, Chief Dan George, Sondra Locke, Bill McKinney and John Vernon. The film tells the story of Josey Wales, a Missouri farmer whose family is murdered by Union militia during the Civil War. Driven to revenge, Wales joins a Confederate guerrilla band and makes a name for himself as a feared gunfighter. After the war, all the fighters in Wales' group except for him surrender to Union soldiers, but the Confederates end up being massacred. Wales becomes an outlaw and is pursued by bounty hunters and Union soldiers as he tries to make a new life for himself. Eastwood was fascinated by the novel and he bought the film rights, hoping to star on the film. He got Philip Kaufman involved as screenwriter and possible director, but left after disagreeing with Eastwood in the material adapted to the screen. Kaufman insisted on filming with a meticulous attention to detail, which caused disagreements with Eastwood, not to mention the attraction the two shared towards Locke and apparent jealousy on Kaufman's part in regard to their emerging relationship. This caused Eastwood to take over as the director. Kaufman's firing angered the DGA, as he did most of the pre-production, and sanctioning a $60,000 fine. This resulted in the Director's Guild passing a new rule, known as "the Eastwood Rule", which prohibits an actor or producer from firing the director and then personally taking on the director's role. The film received critical acclaim, and in subsequent years, is ranked among Eastwood's greatest films. It was also a huge success at the box office, doubling his previous highest grossing film. It was also one of the few Western films to receive critical and commercial success in the 1970s at a time when the Western was thought to be dying as a major genre in Hollywood.
The Gauntlet (1977)"The man in the middle of..."His sixth film. It stars Eastwood, Sondra Locke, Pat Hingle, William Prince, Bill McKinney, and Mara Corday. It follows a down-and-out cop who falls in love with a prostitute, to whom he is assigned to escort from Las Vegas to Phoenix for her to testify against the mob. While it received mixed reviews, it became another box office success for Eastwood, becoming his now highest grossing film.
Bronco Billy (1980)"The most outrageous of 'em all."His seventh film. The film stars Eastwood and Sondra Locke, and focuses on the financially-struggling owner of a traditional Wild West show and his new assistant. It became another critical and commercial success for Eastwood, who referred to the film as one of his most affable shoots of his career.
Firefox (1982)"The most devastating killing machine ever built... his job... steal it!"His eighth film. Based on the novel by Craig Thomas, it stars Eastwood, Freddie Jones and David Huffman. The Soviets have developed a revolutionary new jet fighter, called "Firefox". Naturally, the British are worried that the jet will be used as a first-strike weapon, as rumors say that the jet is undetectable on radar. They send ex-Vietnam War pilot Mitchell Gant on a covert mission into the Soviet Union to steal the Firefox. The film received mixed reviews, but it earned almost $47 million, becoming Eastwood's highest grossing title as director.
Honkytonk Man (1982)"The boy is on his way to becoming a man. The man is on his way to becoming a legend."His ninth film. It's based on the novel by Clancy Carlile, and it stars Eastwood and his son Kyle. It follows Red Stovall, a country music singer and composer. With his nephew Whit by his side, he travels to Nashville to perform at the Grand Ole Opry in the backdrop of the Great Depression. While the film received acclaim, it earned just $4.4 million, becoming his second worst performer.
Sudden Impact (1983)"Dirty Harry is at it again."His tenth film. The fourth installment in the Dirty Harry series, directed, it stars Eastwood and Sondra Locke. The film tells the story of a gang rape victim who decides to seek revenge on her rapists 10 years after the attack by killing them one by one. Inspector Harry Callahan, famous for his unconventional and often brutal crime-fighting tactics, is tasked with tracking down the serial killer. The film received mixed reviews from critics, but it earned over $150 million worldwide, Eastwood's first film to pass that milestone. It's also very popular for including the iconic catchphrase, "Go ahead, make my day."
Pale Rider (1985)"...And Hell followed with him."His 11th film. It stars Eastwood, Michael Moriarty and Carrie Snodgress. A couple and their daughter, along with a few others, are driven out of Lahood, California, by goons working for a mining baron. However, a stranger enters their life to assist them in their fight. There was no stopping Eastwood: another critical and commercial success.
Heartbreak Ridge (1986)"The scars run deep."His 12th film. It stars Eastwood, Marsha Mason, Everett McGill, and Mario Van Peebles. The story centers on a U.S. Marine nearing retirement who gets a platoon of undisciplined Marines into shape and leads them during the American invasion of Grenada in 1983. The film was inspired by an account of American paratroopers of the 82nd Airborne Division using a pay telephone and a credit card to call in fire support during the invasion of Grenada, and fashioned a script of a Korean War veteran career Army non-commissioned officer passing on his values to a new generation of soldiers. Eastwood was interested in the script and asked his producer, Fritz Manes, to contact the US Army with a view of filming the movie at Fort Bragg. However, the Army read the script and refused to participate, due to Highway being portrayed as a hard drinker, divorced from his wife, and using unapproved motivational methods to his troops, an image the Army did not want. It received mixed reviews, with some deeming the film as "imperialist propaganda". But it was still another box office success.
Bird (1988)"There are no second acts in American lives."His 13th film. The film stars Forest Whitaker and Diane Venora. It is constructed as a montage of scenes from saxophonist Charlie Parker's life, from his childhood in Kansas City, through his early death at the age of 34. Eastwood, a lifelong fan of jazz, had been fascinated by Parker ever since seeing him perform live in Oakland in 1946. He approached Chan Parker, Bird's common-law wife on whose memoirs the script was based, for input, and she lent Eastwood and arranger Lennie Niehaus a collection of recordings from her private collection Before Eastwood was involved, Richard Pryor was originally cast as Parker. Despitive positive reviews, it performed poorly, earning just $2.2 million in North America.
White Hunter Black Heart (1990)"An adventure in obsession."His 14th film. Based on the novel by Peter Viertel, it stars Eastwood, Jeff Fahey, George Dzundza, Alun Armstrong and Marisa Berenson. It follows a famous movie director, John Wilson, who goes to Africa to make his next movie. He is an obstinate, contrary director who'd rather hunt elephants than take care of his crew or movie. He has become obsessed with one particular elephant and cares for nothing else. Despite positive reviews, it made just $2.3 million domestically, not even 10% of the budget.
The Rookie (1990)His 15th film. The film stars Eastwood, Charlie Sheen, Raul Julia, Sônia Braga, Lara Flynn Boyle, and Tom Skerritt. It follows a veteran police officer teamed up with a younger detective, whose intent is to take down a German crime lord in downtown Los Angeles, following months of investigation into an exotic car theft ring.It received negative reviews for its acting and story, and it became another flop for Eastwood. That's three bombs in a row. Ouch.
Unforgiven (1992)"Some legends will never be forgotten. Some wrongs can never be forgiven."His 16th film. It stars Eastwood, Gene Hackman, Richard Harris and Morgan Freeman. It follows William Munny, a widower with two young kids, who was once a very vicious gunfighter who gave up everything after marriage. Now, a man named Schofield Kid brings him an offer that he cannot refuse, forcing him to come out of retirement for one last job. David Webb Peoples wrote the script all the way back to 1976, and it was optioned by Francis Ford Coppola, but he lacked the funds needed to helm it. By Eastwood's own recollection, he was given the script in the "early 80s" although he did not immediately pursue it, because, according to him, "I thought I should do some other things first". Eastwood has long asserted that the film would be his last traditional Western, concerned that any future projects would simply rehash previous plotlines or imitate someone else's work. He dedicated the film to his close friends and mentors Sergio Leone and Don Siegel. Hackman initially refused to participate as his daughters were upset that he was starring in too many violent films, but he became fascinated by the script that he agreed. It opened with $15 million and it legged all the way to $100 million after playing for almost one year, closing with $159 million worldwide, his now highest grossing film. The film received Eastwood's best reviews of his career, with many considering the film as his magnum opus as director. It received 9 Oscar nominations, and won four: Best Picture and Best Director for Eastwood, Best Supporting Actor for Hackman, and Best Film Editing. So Eastwood, on top of being a reliable box office draw, was now a 2-time Oscar winner.
A Perfect World (1993)His 17th film. Kevin Costner, Eastwood and Laura Dern, and follows an escaped convict who takes a young boy hostage and attempts to escape on the road with the child, while being pursued by a Texas Ranger.The film received critical acclaim, and has appeared as one of Eastwood's best films. The film disappointed in North America, but it earned up to $100 million overseas (Eastwood's first film to gross that much) and ended with $135 million worldwide.
The Bridges of Madison County (1995)"The human heart has a way of making itself large again even after it's been broken into a million pieces."His 18th film. Based on the novel by Robert James Waller, it stars Eastwood and Meryl Streep. The film is set in 1965, following a war bride, Francesca Johnson, who lives with her husband and two children on their Iowa farm. That year she meets National Geographic photojournalist, Robert Kincaid, who comes to Madison County, Iowa to photograph its historic covered bridges. With Francesca's family away for a short trip, the couple have an intense, four-day love affair. It received more critical acclaim, and made over $180 million worldwide, becoming his highest grossing film. For her performance, Streep was nominated for an Oscar for Best Actress.
Absolute Power (1997)His 19th film. Based on the novel by David Baldacci, it stars Eastwood, Gene Hackman, Ed Harris, Laura Linney, Judy Davis, Scott Glenn, Dennis Haysbert, and Richard Jenkins. It follows a master jewel thief who witnesses the killing of a woman by Secret Service agents.It received mixed reviews, and disappointed at the box office.
Midnight in the Garden of Good and Evil (1997)"Welcome to Savannah, Georgia. A Ccty of hot nights and cold blooded murder."His 20th film. Based on the book by John Berendt, it stars John Cusack and Kevin Spacey. It follows the story of antiques dealer Jim Williams, on trial for the killing of a male prostitute who was his lover. The multiple trials depicted in Berendt's book are combined into one trial for the film. It received mediocre reviews, and flopped at the box office.
True Crime (1999)His 21st film. Based on the novel by Andrew Klavan, it stars Eastwood, Isaiah Washington, Denis Leary, LisaGay Hamilton and James Woods. It follows a journalist covering the execution of a death row inmate, only to discover that the convict may actually be innocent.This was another project that received mediocre reviews and flopped at the box office.
Space Cowboys (2000)"Boys will be boys."His 22nd film. It stars Eastwood, Tommy Lee Jones, Donald Sutherland, and James Garner as four aging former test pilots who are sent into space to repair an old Soviet satellite. It received very positive reviews, and earned over $128 million worldwide.
Blood Work (2002)"He's a heartbeat away from catching the killer."His 23rd film. Based on the novel by Michael Connelly, it stars Eastwood, Jeff Daniels, Wanda De Jesús, and Anjelica Huston. It follows a retired FBI agent who recently had a heart transplant but still takes up the job to nab a killer. It was another film with mediocre reviews and flop status.
Mystic River (2003)"We bury our sins, we wash them clean."His 24th film. Based on the novel by Dennis Lehane, it stars Sean Penn, Tim Robbins, Kevin Bacon, Laurence Fishburne, Marcia Gay Harden, and Laura Linney. It follows three childhood friends who are reunited 25 years later when one of them suffers a family tragedy. Michael Keaton was originally cast in the role of Det. Sean Devine, and did several script readings with the cast, as well as his own research into the practices of the Massachusetts Police Department. However, creative differences between Keaton and Eastwood led to Keaton leaving the production. He was replaced by Kevin Bacon. This was the first film in which Eastwood would be credited as composer. The film had a slow roll-out, but it was aided by strong word of mouth, closing with a wonderful $156 million worldwide. It also received acclaim, and was named as one of Eastwood's greatest films. Sean Penn received universal acclaim for his performance, with some naming it among the best acting of the century, particularly for one scene (if you watched it, you definitely know which scene). It received 6 Oscar nominations, including Best Picture and Best Director for Eastwood. It won two: Best Actor for Penn and Best Supporting Actor for Robbins.
Come back tomorrow for Part 2Don't suggest directors for the next edition here. Save it for tomorrow. |
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2024.05.18 17:44 Thunderblessed63 Rebuilding the Bavarian Juggernaut: Squad Planning and Transfer Targets
Well folks, the season is over, with the final whistle being blown on a 4-2 loss to Hoffenheim, and the remaining excitement now revolves around which manager will Bayern manage to pull in after the massive debacle this past season has been. There is much blame to go around, with Tuchel, many of the key players, and the supervisory board all failing in significant fashion as Bayern fall to third-place in the Bundesliga, and a very early exit in the Pokal in embarrassing fashion (though Bayern did manage to rally for a strong run in the Champions League). submitted by Thunderblessed63 to BayernMunich [link] [comments] Roberto de Zerbi in action. At this point, Italian manager Roberto de Zerbi seems like the most likely candidate, which an announcement coming that he'll be leaving Brighton this season. However, some additional candidates remain available, as Erik ten Hag, Massimiliano Allegri, and some others are still out there and de Zerbi is not a lock to Bayern yet. Ten Hag with Bayern II. Either way, this post explores what I would largely do if the transfers were up to me at Bayern. While the specific manager does play a degree of importance in these decisions, part of this does extensively look at some options who could fit a number of schemes, styles, systems, tactics, and such. My slight preference is for Erik ten Hag, as I think his familiarity from Bayern II and his past success at Ajax would be easier to replicate at Bayern than it was at Manchester United, a club I find is more concerned with its branding than its footballing. But I think de Zerbi has a lot of potential, though I worry about whether Bayern's supervisory board would be willing to let de Zerbi do his own thing, and the lack of German is going to be a problem for that board. It's problematic that the board feels so much need to do things one way and operate in such a chaotic fashion, so whomever Bayern hires is likely going to be fighting an uphill battle. DefenseBayern's future keeper, Nubel (left) and current keeper, Neuer (right).Let's start off with the goalkeeper position, a spot that Bayern are largely set at. Right now, Bayern is set at that spot, as Manuel Neuer continues to be an elite goalkeeper even at 38-years old. And while the Bavarians have Sven Ulreich as the immediate backup keeper, Alexander Nübel is the long-term successor being eyed and groomed for the role, recently extending his contract at Bayern, though he remains loaned out to Stuttgart. Then of course there's also Daniel Peretz, a 23-year old keeper that Bayern added this past season. He seems likely to head out to a club such as RSC Anderlecht for a loan period for awhile this summer. In the meantime, Bayern might have Johannes Schenk back from Muenster to fill that third keeper on the roster, or he might get loaned back out once more. Overall, Bayern appear to be in really good shape for the goalkeeper spot, with Neuer continuing to lock things down for another season or so, before probably passing the torch over to Nübel in 2025 or 2026. Shifting to the centre-back position, Bayern right now seem to have a good deal of interest in adding another big time centre-back, with rumored links of varying degrees to Ronald Araujo and Virgil van Dijk. This would likely mean that at least one current centre-back would need to be sold, as Bayern have a decent enough set of four starting caliber CBs on the roster, headlined by Matthijs de Ligt, but also including Kim Min-jae, Eric Dier, and Dayot Upamecano. My guess would be that if any departs, Upamecano is the most likely, given his inconsistent play and limited role in the lineup these days. De Ligt is the leader of the backline and has had some terrific outings as of late. Min-jae was a big time signing this past summer from Napoli, but has had some bumps along the way adjusting to life in Germany, and meshing into the current defensive system, which is quite hectic from the frequency of errors committed as a whole. Min-jae was excellent at Napoli and so it would not be too difficult to project him returning to that level of form after additional time in Bavaria. Eric Dier was brought in as a late in the window depth addition, but so far has become a very solid add, starting a good number of matches alongside de Ligt. And whether he projects to start or is a rotational player next year, Bayern have already triggered an option to keep him next season. He's a solid piece to the puzzle overall, capable of giving them some veteran experience, and another Englishman alongside Harry Kane. If Bayern did opt to sell Upamecano, then they reasonably could take a look at some other options to add into the mix. The top end of options here probably starts with discussing Ronald Araújo further, a 25-year old Uruguayan star for FC Barcelona. He's been a long desired prospect for the Bavarians, but he'd cost a pretty penny no doubt, as some have projected it could be upwards of 100 million € to acquire the talented CB. That's a big price tag, especially after Bayern spent almost €60 million last summer to bring in Min-jae. Riccardo Calafiori in action for Bologna. Should de Zerbi take the Bayern job, it's already been rumored that he has some targets in mind, namely Bologna center-back Riccardo Calafiori, a 21-year old Italian talent who can also handle some duties at left-back. He's been excellent this past year under Thiago Matta, and could fill a very valuable role for Bayern, competing with Min-Jae and Dier for the starting position next to Matthijs de Ligt. He also happens to be a left-footed defender, something Bayern have been lacking there as of late. Some more middle tier options that peak the interest could be Kevin Danso, a 25-year Austrian CB playing for RC Lens in France. He spent a handful of seasons at Augsburg, and so has a good deal of Bundesliga experience and 100 appearances for Les Sang et Or these past three seasons. He's projected to cost about €25 million, so a much cheaper option that could fit well. Another mid-tier option could be Maxence Lacroix, currently in the Bundesliga at Wolfsburg. He's valued at about €20 million, and is a very strong and menacing presence on the backline, still 24-years old. He did get cooked a couple of times against Bayern, which probably harms some appeal there for some, but week-to-week he's been a quality player for Wolfsburg. The third name I'd mention here is Feyenoord's Dávid Hancko, a 26-year old Slovakian talent. He's a smart, savvy defender, and also provides some versatility between centre-back and left-back, which could be quite useful going forward. Oh and I'd be remiss to not mention German national Malick Thiaw, currently at Milan, as another promising option there. The other option is to go with a younger, less established talent, someone like Armel Bella-Kotchap, who landed on Bayern's transfer rumor threads a good deal in the winter circuit as they were searching for some defensive help. At left- and right-back, Bayern are in another similar spot where they might be fine, as the Bavarians have a deep rotation of capable options, but positional versatility, injuries, and inconsistent play have caused varying levels of upheaval. Let's start with this one -- if Bayern's new manager is able to convince Joshua Kimmich to remain as a right back, that would be one of the biggest wins they could manage. Kimmich is an elite player at the position, and while he's certainly a high caliber midfielder as well, I think he's best at right back. Whether that's likely or not, is a to-be-determined piece, but it should absolutely a conversation a new manager has with Kimmich. While Bayern has kept its contract offer on the table for Alphonso Davies, I must admit, whether this is a popular position or not, I would not be a huge fan of Davies remaining with the club at this point. Part of this is because it very much appears as though Davies largely checked out of the season, instead letting all the plotting of a Real Madrid move occupy his headspace, leading to some very uninspired performance. Essentially, I hate to put it so bluntly, but I have been unable to really see it any differently despite my best desires to, it really looks like Davies quit on his team midway through the year, dreaming of Madrid. Whether Madrid come in with an offer at this point or not remains to be seen, but I would look for a way to remove Davies. As much as he offers a lot of potential, any new project for Bayern is going to require players who are bought in to making it happen once against in München, and I just cannot see that happening with Davies at this point. Behind him, we've seen some excellent play down the stretch from Raphaël Guerreiro and Noussair Mazraoui, tag teaming duties at left-back and left wing to various degrees. I think if Kimmich is willing to man the right-back position, then a trio of Mazraoui, Guerreiro, and promising youngsters like Frans Krätzig and Adam Aznou would be sufficient. Milan's Theo Hernandez, potentially Bayern's new left-back. Bayern have been linked, however, with major moves such as AC Milan's Theo Hernandez, a world class player with elite pace and ability. They've also apparently looked into hijacking a potential reunion of Ian Maatsen and Borussia Dortmund, as the Chelsea-owned talent was quite good in Dortmund on loan. BVB would like to get Maatsen permenantly, though Bayern could pull a heist there. I think Bayern could also look at some other German options, such as 27-year old Stuttgart left-back Maximillian Mittelstädt, who recently broke out to the tune of some national team call-ups lately, or perhaps emerging youngster Luca Netz, who looked very promising at Borussia Mönchengladbach this past season. And then the final note here, but Bayern are likely set with their right-back room, as Joshua Kimmich, Noussair Mazraoui, Josip Stanišić, and Sacha Boey are all on the team. However, there have been rumors that Bayern are interested in Leverkusen's Dutch phenomenon there, Jeremie Frimpong. While he plays as a very forward-oriented RWB, he's a very prolific player outright, with tons of big moments for Leverkusen this past season and a big part of their success. MidfieldDo not for this one, while the no. 10 position is classified as a midfield position, I am including it in attack, with this one more just focused on the no. 6 and no. 8 roles in the midfield.Pavlovic had a breakout season in Bavaria. Bayern's midfield is going to need a major reshuffle. The two most certain pieces to be kept around are emerging youngster Aleksandar Pavlović, an academy talent who has worked his way up to being a go-to starter late into the season, and Konrad Laimer, who is valuable due to his versatility, intensity, and toughness. Kimmich, we'll touch on more below, but in the mean time, one of the major questions for any midfield duo at Bayern is going to be who departs and how things align? I think the one guy probably on the outside looking in is going to be Leon Goretzka. He's had his moments, some ups and downs, but right now figures as the odd man out for assorted reasons, namely the need for more defensive help in the midfield. Goretzka would have a market too if Bayern opted to move forward without him, with teams such as Juventus, Manchester United, and West Ham all having interest over the past year. Unknown. I'd lean towards a departure, even if only because Kimmich in the midfield is a better overall asset, and Bayern would need to free up some funds to acquire a better midfield partner than Goretzka provides. Then of course there is 29-year old Joshua Kimmich. Mentioned him earlier as ideally slotting in at right back for Bayern going forward, but he's also proven to be quite capable in the midfield. He's excellent at dictating the play going forward, with timely, precise passes, and an aggressive demeanor. He's not terribly reliable as a no. 6, and some of this was the source of the rift between Kimmich and Tuchel earlier this summer, where he and Tuchel were somewhat publicly feuding over whether or not Kimmich could handle that role. Ultimately, I do think Kimmich is better as more of a no. 8, with a more defensive-oriented type of player brought in to compliment him. I think in that role, Kimmich can be wildly successful for Bayern in the remaining years of his career, but a long-term extension is needed at this point. As I've said earlier, I would prefer to keep Kimmich as a right-back, but I am quite content keeping him in the midfield if Bayern can find that no. 6. Everton's Amadou Onana is a tempting target for Bayern. And speaking of the need for a defensively minded midfielder... I do believe there is one genuinely excellent option there, with Everton's Amadou Onana available. Onana is a Senegalese-born Belgian national, and came up playing in Germany, with time at Hoffenheim II and Hamburger SV. Thus, he's fluent in German and could integrate to life in München quite easily. He's a very disruptive defensive stopper, with excellent ability to make tackles, halt offensive build-ups, and then quickly turn and push the ball forward for his side to go on the counteroffensive. He's an ideal fit for the system, able to help turn defense into offense in a hurry. Another one for the no. 6 that's been mentioned for Bayern is Adam Wharton, currently at Crystal Palace. The 20-year old English midfielder had an excellent season this past year. The other one that I would anticipate being a priority if we see ten Hag taking over is a ramped up pursuit of Barcelona's Frenkie de Jong, a fellow Dutchman who was at Ajax under ten Hag for awhile. De Jong's had some injuries issues plaguing him lately, but when he's on, he's an excellent possession-oriented central midfielder, bringing a very well-rounded game as well that includes some noteworthy capacity with dribbling, defense, and passing as well. De Jong also has a notable history/connection with Bayern's Matthijs de Ligt, which makes it seem more feasible that he'd integrate well into the team. In many ways, I think de Jong probably only makes sense as a replacement for Kimmich if he were to depart. Additionally, while he has been mentioned more as a Tuchel target than anything else, Fulham's Joao Palhinha is an intriguing option as a defensive midfielder. He's an elite tackler and defender in the middle of the defensive half, and shows some solid ability to distribute the ball and lead the build-up. Personally, I think Palhinha is the ideal partner in the midfield to be paired with Aleksandar Pavlovic, whereas Onana next to Kimmich is more preferable there. So some options based on how Bayern wants to set-up. And one other name that could pop up here is Mats Wieffer, currently at Feyenoord, a central figure to Arne Slot's success there. A 24-year old Dutch midfielder, Wieffer has been an excellent option in Slot's midfield, and it seems likely he'll be pursued by Liverpool with Slot taking over there, but Bayern could perhaps try to hijack it. While at this point, I think Bayern would probably add Onana or Palhinha, maybe de Jong if Kimmich leaves, and then call it a day with Konrad Laimer and Aleksandar Pavlovic there as well, with Kimmich maybe even splitting some time between right-back and midfield throughout the season, there could be room for more players to be added. For some additional depth in the midfield, I think Bayern would do well to go after former academy player Angelo Stiller, who appeared in almost 30 matches this past season for third-place Stuttgart. The 23-year old is an excellent passer, able to distribute the ball forward with precision and anticipation. He'd be a nice reunion for Bayern as well, as he's also born and raised in München, and was added to the national team roster for the EUROs. However, I think Stiller's probably one that Bayern does not really need at this point, though if additional midfield help becomes a need (say perhaps next winter), then he's one to continue monitoring. One other name here would be OGC Nice's Khéphren Thuram, a talented 23-year old midfielder who is quite cheap considering his talent. His brother played for several years at Borussia Mönchengladbach. Another younger option I'd love to add to the roster here would be 17-year old Sverre Nypan, a Norwegian midfielder who currently plays in-country with Rosenborg BK. I admittedly don't know much about Nypan personally, but am going off of something from I read earlier about Ten Hag and United already monitoring his progress. He'd be a nice piece to add to the mix with other young midfielders like Zovrenek and Wanner coming through the ranks. However, I think a loan for at least one of them would be worthwhile. AttackSimons has been electric this past season at RB Leipzig.Looking at the no. 10 role for Bayern, I have some questions. Jamal Musiala is an exceptional talent, and at only 21 years old, Bayern need to be doing everything in their power to extend him and make him the central figure of the club in the years to come. But, as far as position goes, he's very versatile and that allows for Bayern to get very creative in how they configure their attack alongside him. And while Leverkusen's Florian Wirtz is a top target for the 2025 transfer window for Bayern, I do tend to agree with take from Complexes on Twitter, that Wirtz probably follows Alonso to Madrid in 2025, and thus I'd be very much in favor of Bayern opting to add Xavi Simons from RB Leipzig this summer. This isn't to say Bayern should abandon its pursuit of Wirtz, but rather that I'd say that Bayern should pursue Simons this summer and be quite happy/content to land him, lest they risk going 0-2 on both if Wirtz does indeed land with Madrid next summer. The thing I love most about pairing Simons and Musiala together is the versatility and creativity. While both tend to occupy a spot more frequently as a central attacking midfielder, Musiala has played a decent amount of time on the left wing and Simons has also played over as a right wing. Add in Bayern's current right winger, Leroy Sané, also showing some versatility between right wing and occasionally cutting in and operating centrally, and you have the recipe for a versatile, ever changing, flexible attack that can advance the ball. Overall, I think Simons addition into Bayern's attack would unlock a new level of effectiveness for the incoming regime. The other one to mention here is Schalke academy product Assan Ouédraogo. At just 18-years old, Ouédraogo has already landed on the monitor of Bayern and RB Leipzig, and the two clubs appear to be battling for his signature. A move to acquire Ouédraogo and then loan him back out for more experience, whether back to Schalke or moving him up to the Bundesliga, would seem to be a solid plan for the Bavarian giants to see if Ouédraogo could become a long-term fixture in their lineup. If a move for Ouédraogo falls through, another young attacking midfield with immense promise that I think Bayern should look at is 16-year old Polish midfielder Jakob Adkonis, currently at Legia Warsaw. He'd definitely be a development piece long-term, but the upside is very high. Then looking at the wing spots, Bayern are in an interesting spot. Jamal Musiala and Thomas Müller have interchangeably slotted in as attacking midfield types with the ability to spell time out on the wings. Serge Gnabry and Kingsley Coman are both very talented options there, but suffer from a lack of reliability with their frequent injuries. Fuhrich is a very solid player who could be a strong add for Bayern. This section thus deals with a lot of ifs. I think Bayern could theoretically look at it and say Serge Gnabry, Kingsley Coman, Jamal Musiala, Thomas Müller and then maybe some Mathys Tel, as well another who can play wing at a good level, and be content. But, if they choose to sell one of Gnabry or Coman, which I think they should, Bayern could be in the hunt for a replacement there. They've already been linked with German international talent Chris Führich. He has been very good for Stuttgart this past season, and would only cost Bayern a fraction of some bigger names. At 26-years old, Führich could still give Bayern a solid run of play, and has shown some versatility to alternate sides or even drop into the midfield as required. He's a steady and solid player, not a superstar by any means, but could serve as a valuable rotational piece if Bayern do move on from Coman or Gnabry. Another option would be the speedy Nico Williams, a 21-year old Spanish winger playing for Athletic Bilbao. He's going to be in the very expensive price tag range, but with his combination of potential, production thus far, and excitement, he could be well worth the cost. Another younger option here, and a more affordable one, would be Brajan Gruda, a 19-year right-side winger playing for Mainz. He infamously had the jersey swap photo already with Thomas Müller and seems like a rising talent with 27 appearances for Mainz. While Gruda statistically hasn't had much production thus far, at just 19-years old, he's given some very promising performances against the likes of Bayern and Dortmund as well while getting acclimated to life in the Bundesliga. If Bayern continues to play Tel more as a winger than a true no. 9 striker, which I think is also the correct call, then Bayern are going to need to be in search of a strong replacement for Eric Chuopo-Maxim after this season, a genuine backup to Harry Kane. There are two routes they can go which is to either find a youngster who could theoretically take over for Kane in 2-3 years (as most of the reports indicated he'd probably want to return to the Premier League before the end of his career to chase the all-time EPL goal record), or a veteran looking to milk the last couple of years out of their career and be a part of a championship squad. If Bayern go the youngster route, two names that stick out are Leipzig's Benjamin Šeško, a towering 20-year old Slovenian who has looked really sharp in Leipzig spelling Lois Openda. Sesko would likely cost a pretty penny, but if Bayern are willing to pay it, I think they should make that move. If they want a more budget friendly option than perhaps angling for Hoffenheim's recent DFB call-up, Maximillian Beier as a promising up-and-comer could be in the cards. Beier scored against Bayern in the final match of the season. Not as young, but Wolfsburg's Jonas Wind, a 25-year old Danish talent, could perhaps fit nicely, as he can also operate as a second striker and produced 11 goals in the Bundesliga this past season. If Bayern want a veteran option, Serhou Guirassy has been a player that Bayern are already linked to. He's also got some interest from Dortmund and Tottenham as of late. While Guirassy is a fun player, and a talented one, as he was second in the Bundesliga in terms of goals scored, I don't think that he should be a significant priority for Bayern, as they need to allocate funds to other positions before coming around to landing a backup striker to Harry Kane. And since we've mentioned significant versatility for a lot of others, both Mathys Tel and Thomas Müller could certainly be able to fill in situationally, though if there's a major injury to Kane that becomes more problematic. Personally, the move I think is much more likely is finding a veteran striker on a lower level squad who might be interest in chasing some titles with a bigger club. Bayern added Chuopo-Maxim as a 31-year old, albeit from PSG rather than a smaller club, but I do think it's a decent example of a reasonable move Bayern can make to shore up their depth without breaking out too much spending. Two names I think really intrigue in this kind of mold are Hoffenheim's Andrej Kramarić, a 32-year old Croatian forward who scored 15 goals this past season for Die Kraichgauer, including a hat trick against Bayern in the season finale as well. The other one is Tim Kleindienst, a 28-year old German who has played largely in the 2. Bundesliga but has spent a few seasons in the top league at Heidenheim and Freiburg during his career. He had an excellent showing in Heidenheim's upset win over Bayern earlier this season, netting himself a brace, two of his twelve total goals this season. Both are veteran, experienced strikers with some capacity, but might be open to a diminished role behind Harry Kane in order to potentially get some bigger opportunities with Bayern's pedigree. Final Squad PlanningNow, time to prioritize.
And of course, that means a number of players need to depart. Here's ultimately who I'd move on from:
Bayern Munich "Depth Chart" 2024-2025 SeasonHarry Kane (left), and Joshua Kimmich (right front) are major pieces for Bayern's chances at a turnaround.The idea of a "depth chart" isn't used in international football as much as it is in other sports, namely American football. However, think it's a useful organizational tool to get a feel for roughly what the squad would look like headed into this next season. The bolded names are the ones I'd most want in an ideal starting XI, and then the rotation and depth players would also see various minutes based on how far into the Champions League, Pokal, and other competitions that Bayern goes through, or injuries require.
Loans
Probably plenty of other good options, and I'm sure there's some parts that'll happen quite differently than projected, but this would be my ideal outcome for Bayern at this stage in the process. It's been a rough process so far, but think there's still lots of potential for Bayern with a revamped and refreshed squad. |
2024.05.18 17:26 Vast_Initiative_9019 Seems like a simple fix but I can't find it
https://preview.redd.it/p38keaufd71d1.png?width=1902&format=png&auto=webp&s=7913231dda2e46856e8831a8e8370d824a522182 submitted by Vast_Initiative_9019 to tableau [link] [comments] Hey! Here I have made a absolute cumulative frequency of language which are used when streaming on twitch, how can I now make it into relative cumulative frequency? Essentially just swapping out the numbers on the lable for percentage values instead? Btw it might be worth to mention that I achieved this by doing a Quick table calculation for the running total :) |
2024.05.18 16:13 Hairy-Royal-2207 [Hobby][RevShare] Seeking 2D Pixel Art Artist and Writer for Collaboration on Farming RPG
2024.05.18 15:59 Dida1503 I can't stop making languages
2024.05.18 15:04 MGK_2 Changing Gears
"The study will be conducted by lead principal investigator, John L. Marshall, M.D., Director, The Ruesch Center for the Cure of GI Cancers Frederick P. Smith Endowed Chair, Chief, Hematology and Oncology Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D.C."I wasn't around at the time to know for sure, but I believe this trial was set up by Nader. Eventually, this study would be withdrawn for reasons which I am about to disclose.
"Nader Pourhassan, Ph.D., CytoDyn’s President and Chief Executive Officer, said, “We anticipate this study will further evaluate the immunomodulatory effects of leronlimab in the tumor microenvironment. We are excited about the possibilities for leronlimab to offer a potential new treatment option for breast cancer patients. This could be an additional indication for which we are pursuing approval for leronlimab. We are also very grateful to Dr. Scott Kelly for arranging for this study to be conducted by Dr. Jangsoon Lee, assistant professor of Breast Medical Oncology Research at The University of Texas MD Anderson Cancer Center."Cyrus Arman comes onboard as President effective July 9, 2022. During that summer of 2022, the CYDY share price ran up as high as $1.26 per share for some unknown reason. In the past, I attributed it to NASH. I give a breakdown of my thinking here in I Tell You A Mystery. In the commotion of Cyrus' hiring and the mass fluctuations of the share price, the MD Anderson Study had already been completed and the results were looking good to those privileged enough to have been granted rights to actually see the data. Coincidentally, it was about this time that the CRC with Regorafenib was withdrawn. Hmmm, Why was this trial withdrawn? Just because the MD Anderson results looked great or because there was something even more profound and substantial built upon those results?
"We can apply the same logic in the Oncology study being run by MD Anderson using Merck's Keytruda in combination with Leronlimab. We had all been waiting to find out what had happened with the results of the MD Anderson study, and Cyrus threw us this line: "Leronlimab is currently being trialed in combination with Keytruda (pembrolizumab) in a breast cancer xenograft model in partnership with MD Anderson Cancer Center." From here, he gave us a hint of what is to come."In his infamous 12/7/22 R&D Update: Future Development, Cyrus presented his Vision & Plan for the Company:
"17:09: And we're also still committed to HIV, but we're really looking at it more through the lens of developing longer-acting agents. And Dr. Sacha will be talking about that at the end of our discussion today.The FDA made it truly tough for Cyrus to meet his goals as the Company's main devotion was to get the hold lifted, so Rules had to be followed. Also, Cyrus unfortunately made NASH a focus and then subsequently became sick and then found himself taking a demotion. His focus really should have been on Oncology as #1 target as it finally is today. Here though is a revealing statement he made:
17:21: So, within oncology, we're interested in studying what would be referred to as immunologically colder tumors. And Dr. Glück will present on what those -- what we mean by that later. But we think that these are areas where more recent advancements from checkpoint inhibitors have yet to really have a large impact in those markets. And so, we think that there's a unique opportunity based on the data we already have in some of these colder tumors to make an impact.
17:51: Within NASH, we're particularly excited about the data that we have there, and NASH will be our primary focus going forward. We'll also talk a little bit about a unique opportunity to study and look for the treatment effect of leronlimab in people living with HIV who also have NASH. And we think that we might be in a unique position to address that population."
"18:22: So, going forward, we're focusing on NASH, oncology and earlier-line HIV indications through longer-acting agents that inhibit CCR5. Again, we've already generated promising clinical signals in both NASH and oncology. And within NASH, we're exploring the opportunity to study a segment of patients of those NASH patients who are also living with HIV.
18:50: Within oncology, we want to pursue colorectal cancer and breast cancer specifically. Within the colorectal cancer population, we want to focus on a micro-satellite stable group, which represents about 85% of all diagnosed colorectal cancers. And within breast cancer, we want to focus on the hormone receptor positive HER2-negative population, which is about 70% of all diagnosed breast cancers, and the TNBC population since we have data in that space. All of these are quite large markets."
"...these are areas where more recent advancements from checkpoint inhibitors have yet to really have a large impact in those markets. And so, we think that there's a unique opportunity based on the data we already have in some of these colder tumors to make an impact."Keeping that escalation in share price to $1.26 in mind, when did CA know about this data? He got the data on the MD Anderson results either before or shortly after his hire. Remember, shortly after NP was terminated, Cyrus was at CytoDyn working at least for a few months prior to his hire giving opportunity to the BOD to assess his work ethic and ways about him. In this time, CA saw the MD Anderson results and they were looking mighty good. Where are these results today? They still reside with MD Anderson. Why don't we have them right now? Too many $millions to buy it, but we saw the results and those results are the impetus for the change in gears of the Company's priorities. Surely Scott Kelly, who was responsible for securing the MD Anderson study has seen them as well.
"What also happened in August? Only the removal of the first management player who’s experience was in Negotiation and Partnerships, Brendan P. Rae. No longer any necessity for Negotiation? I guess not. As time went quickly by, without any word of what was taking place, the share price began to fall. It became uncomfortably obvious that by mid November, Recknor had been let go. He was CytoDyn's most experienced scientific, medical and managerial player for NASH, but in the game of a collaboration, anyone and everyone is a commodity and all are replaceable. On the same topic, a significant stock bonus was paid to the president in September of last year after only two months on the job. Was a deal struck? Also, our very own CMO, Scott Kelly who coined the phrase: “There are many ways to structure a partnership.“ himself gets terminated in December 2022."Just like that bonus, (which was based on his obtaining a partnership), the short-lived share price rise also assumed that a deal had been struck. Scott Kelly was privy to the MD Anderson results just as Cyrus was. Why didn't Kelly put a deal together like Cyrus did? I don't want to diminish the fact that Kelly was wholly responsible originally for getting the MD Anderson murine study going. The fact is that a deal had been made and justifies Cyrus' bonus payment.
"25: 25 Kelly: We are excited about the Basket Trials. I'll start by saying I just presented at San Antonio Conference December 10th. That was in results wrt mTNBC in combination with carboplatin, CCR5 positive, mTNBC and I tell you, the reason why we are excited about the Basket Trial is that they think that there is a growing acceptance that the Tumor Micro Environment is the next Frontier for Immunotherapy. And I mean this amongst practicing physicians, the academic world, probably as well as big pharma, and I think we are more advanced than this. We've been looking at the mechanism of action in the tumor micro environment and see Leronlimabs impact across multiple different oncologic indications and we also think that we can pair this with a check point inhibitor, chemo, radiation, antibody zero conjugates, as well as maybe even a potential monotherapy in certain patients that don't qualify for other treatments. We think the MOA, with T-Regs. When T-Regs come in, they turn off the immune system. We know that they have a high prevalence of CCR5. We can block that. We can actually maybe leverage the immune system. If we look at macrophage re-polarization, that's another potential opportunity. Our animal studies showed a significant reduction in angiogenesis. I think it was 62% in total vessillary and 80% reduction in small vessel area. But, we know that tumors need a blood supply to grow and if we can help limit that, then we think we can have benefit for patients. And last, we know that normal cells, CCR5 is only present on an immune cell, but we know that when cells under go malignant transformation, that they start sprouting up CCR5, and we believe that is a contributor to metastasis. So, we have multiple different mechanisms of action and we continue to find more as we go along that we will be evaluating."He remembers Dr. Gluck's discussion in the 12/7/22 R&D Update Dr. Stefan Gluck; MicroEnvironment.
"So, as you saw, very small studies, but extremely promising, and the signal for an oncologist like myself is so strong that I'm enthusiastic about it. We, as oncologists, need to be positive because otherwise, we cannot treat patients and tell them something better is coming. The leronlimab decrease of these tumor cells actually did relate both in mTNBC and in colorectal with improved survival. That's amazing."Cyrus turns to our 3rd party AI collaborator and requests an assessment on the effect of a CCR5/L5 axis blockade in mCRC. Their AI engines get to work and compile all that is known and understood regarding the pertinent Biomarkers in combination with all the pertinent journal articles on the blockade of the CCR5/L5 axis in the disease to finally determine that it works like a charm, like no other.
"The majority of patients with CRC exhibit a microsatellite stable (MSS) or mismatch repair proficient (pMMR) status, which is known as the “cold tumor” with less mutated oncogenes and less inflamed tumor immune microenvironment, resulting in a limited efficacy of ICIs (2). The inadequate recruitment and activization of immune cells to the tumor microenvironment were considered to be fundamental mechanisms underlying the inefficacy of ICIs in MSS mCRC (4). Combination strategies to enhance the immunogenicity of the tumor microenvironment and exploit the benefit of ICIs in patients with MSS are urgently needed."He becomes even more convicted. Given all that I presented here in addition to the proven results of the MD Anderson, Keytruda study which Cyrus has laid his own eyes upon, he becomes whole heartedly supportive of the Priority switch to the mCRC Oncology Indication. I'm sure Richard Pestell was also 100% behind Cyrus in this decision to switch priorities. Also, by switching to Oncology, share price has a better chance of increasing as Oncology is favored by the public. Fund raising could happen much quicker with a higher share price resulting from a better indication. From the recent May 2024 Letter to Shareholders:
"Over the next six months, we expect to commence at least one, and potentially two clinical trials. The prospective clinical trials, in order of priority, are: (i) a Phase II study of leronlimab in patients with relapsed/refractory microsatellite stable colorectal cancer; and (ii) a Phase II study exploring leronlimab’s effects on inflammation. The Company’s priority will be the oncology trial which, if successful, will put us on track towards a commercial approval of leronlimab in that indication. The inflammation study is aimed at clarifying certain provocative observations related to leronlimab, and to help define the dose and underlying mechanism of anti-inflammatory action. It is imperative that the Company generate unassailable results in the clinic and I believe the above trials can accomplish this. Starting the oncology study and related fundraising is the top priority of the Company at this time, but our current hope is that we can initiate both studies before the end of this calendar year."So straight from the CEO's mouth, related fundraising is the top priority of the Company at this time. Cyrus remains here at CytoDyn because of the need to pump up the value by switching to a more attractive Indication Priority. I repeat all of this, because with all of the peer reviewed and published Journal Articles that discuss the CCR5/L5 axis in the context of Colo-Rectal Cancer and given Keytruda's exceptional performance as a PD 1 blockade in only 15% of these CRC MSI tumors, leronlimab can open the door wide open to the remaining 85% MSS tumors. The trial starts this year. Also from the recent Shareholder Letter:
"Research and development partnership opportunities are important to the Company as we search for cost-effective ways to further build out our product development portfolio. We have identified several such opportunities that we believe are intriguing and anticipate finalizing agreements with these partners in the very near future. Such potential partnerships include an investigator-initiated pilot study of leronlimab in patients with Alzheimer’s Disease, and a project that will evaluate the use of leronlimab in patients living with HIV who are undergoing stem cell transplantation in a proof of cure study. Following lifting of the clinical hold, we have observed a significant increase in third parties that are interested in partnering with the Company. We will continue to review opportunities as they arise, given the potential for significant value return at little or no cost to the Company."The question I now have is with whom? Partners are incoming, but did leronlimab make it easier for the PD-1 blocker Keytruda to work in MSS mCRC tumors? If it did, (and Cyrus knows if it did or did not), then Merck certainly remains there in the bidding. If leronlimab did it all by itself and Keytruda was superfluous, then the partner might be someone like u/i__OBSERVER points to entities such as the NIH as the source of that funding.
2024.05.18 12:49 V-by-V My collection of dinosaur/paleo books. Feel free to ask if you have questions about any of them/want to see pictures from the inside
Pterosaurs submitted by V-by-V to Paleontology [link] [comments] • The Princeton Field Guide to Pterosaurs, G. S. Paul, 2023; english; 176 pages; images in color and b/w on almost every page (skeletal diagrams, reconstructions, sceneries, etc); high school+¹ • Pterosaurs, M. Witton, 2013; English; 263 pages; images in color on almost every page (skeletal diagrams, photographs reconstructions, sceneries, etc); high school+ Marine Reptiles • Ancient sea reptiles, D. Naish, 2022; English; 185 pages; images in color on almost every page (skeletal diagrams, photographs reconstructions, sceneries, etc); high school+¹ Dinosaurs (children books) • Dinosaurier!, 1993; german²; collection of magazines; elementary-middle school • Mein großes Pop-Up-Buch der Dinosaurier, P. Watson, 2002; german; colorful pop up structures on every page/about 1-2 sentences description per page; 10 pop up sculpture/20 pages; pre-school • Wieso? Weshalb? Warum? - Alles über Dinosaurier, P. Mennen, 2000; german; colorful pictures on all pages, some parts of pages can be folded open to reveal additional images; 16 pages; pre-school-elementary school • Kinderwissen - Dinosaurier, B. Oftring, year unknown; german; colorful pictures on all pages; 125 pages; pre-school-elementary school • Bei den Dinosauriern, O. Maier, 2000/1993; german²; colorful pictures on all pages; 47 pages; elementary school-middle school • Sehen, Staunen, Wissen - Dinosaurier, S. Mitchell, S. Unstead, S. McKeever, 1989/2002; german²; colorful pictures and photographs on all pages; 63 pages; middle school • Die Spuren der Dinosaurier, N. Harris, S. Naoura, 2002; german²; colorful pictures (sceneries) on every page; 29 pages; pre-school-elementary school • Europasaurus, O. Wings, J. Knüppe, 2020; all text in german and English; graphic novel/colorful scenries on all pages; 181 pages; elementary school+ • Das Kosmos-Buch der Dinosaurier, K. P. Creamer, J.-C. Rost, 1992, german; colorful and b/w pictures on all pages; 92 pages; elementary school-middle school • Das große Buch der Saurier, P. Klepsch, T. Thiemeyer, 1989, german; colorful pictures on all pages; 60 pages; elementary school-middle school • Was ist was - Dinosaurier; J. Oppermann, 1999; german; colorful pictures on all pages; 47 pages; elementary school-middle school • Der große Ravensburger Atlas der Dinosaurier; S. Davidson, S. Turnbull, R. Firth, W. Hensel, 2004; german²; colorful pictures on all pages, maps showing fossil locations; 113 pages + 22 pages of data sheets; elementary school-middle school • 1000 Dinosaurier, H. Werner, year unknown, german, colorful pictures on all pages; 327 pages; elementary school-middle school • Der Dinosaurier im Fels, S. Vry, C. Lieb, 2023, german, colorful pictures on all pages; 105 pages; elementary school+ Dinosaurs (adult-ish) • Dinosaur Facts and Figures - The Theropods, R. Molina-Pérez, A. Barramundi, 2019, english; colorful pictures on the majority of pages (reconstructions, bones, etc), tables, data sheets; 285 pages; middle school+ • The Princeton Field Guide to Dinosaurs (2nd edition); G. S. Paul, 2016, english, images in color and b/w on almost every page (skeletal diagrams, reconstructions, sceneries, etc); 349 pages, high school+¹ • Dinosaurs - The most complete, up-to-date encyclopedia for Dinosaur lovers of all ages, T. R. Holtz, L. V. Rey, 2007, english; colorful pictures on all pages; 366 pages + 47 pages of dinosaur genus lists; middle school+ • Dinosaurs - The grand tour (2nd edition), K. Pim, F. Pastor, J. Horner, 2019, english; images on most pages (silhouettes, b/w reconstructions colorful sceneries), 356 pages, middle school+ • Aufstieg und der Fall der Dinosaurier (the rise and fall of thr dinosaurs), S. Brusatte, 2020, german², b/w photos and reconstructions on some pages, 361 pages, adults • Ausgestorben um zu bleiben, B. Kegel, 2018, german, b/w images on some pages, 257 pages, adults Earth's History (children) • Wundervolle Welt der Dinosaurier und der Urzeit, A. Chinsamy-Turan, 2021/2022, german², photograph of fossil+ colorful reconstruction on every double-page, 223 pages, elementary- middle school (+) • Alles über die Urzeit, R. M. Wood, 2002/1995, german², colorful pictures on all pages; 45 pages; elementary school • Leben in der Urzeit- Von den Dinosauriern bis zu den ersten Menschen, D. Editore, 1999, german; colorful pictures on all pages; 52 pages; elementary school • Was ist Was - Dinosaurie Der Urmensch, D. Gleis, 1982, german, colorful pictures on all pages; 92 pages; elementary school-middle school Earth's History (adult-ish) • Eine (sehr) kurze Geschichte des lebens (A (very) short history of life on eartg), H. Gee, 2021, german², some diagrams about geologic time scales, 246 pages, adults • Urwelten (otherlands), T. Halliday, 2022, german², a b/w map and reconstruction at the beginning of each chapter, 395 pages, adults • Locked in time, D. R. Lomax, B. Nicholls, 2021, english; 50 scenery reconstructions (one per chapter) and additional photos/diagrams, all in b/w; 286 pages³, high school + Prehistoric Mammals • The rise and reign of the mammals, S. Brusatte, 2023, german², b/w photos and reconstructions on some pages, 528 pages³, adults • The Prince field guide to prehistoric mammals, D. R. Prothero, M. P. Williams, 2017, english; colorful images/photos on almost every page (fossils, reconstructions, sceneries, etc); 230 pages, high school+¹ • Beasts before us, E. Panciroli, 2021, english; b/w sceneries at the beginning of each chapter, some additional diagrams, 8 center pages with colorful photographies; 298 pages; high school+/adults?¹ Cats • The big cats and their fossil relatives, A. Turner, M. Antón, 1997, english; b/w reconstructions, skeletal drawings and diagrams on almost every page, 16 center pages with colorful scenery reconstructions; 220 pages; high school+/adults?¹ Evolution of flight • Der Flug des Archaeopteryx, L. Bollen, 2008, german, colorful phots, reconstructions and diagrams on almost all pages; 259 pages; high school+/adults Extinction • Das 6. Sterben (The sixth extinction, 3rd edition), E. Kolbert, 2016/2021, german², b/w photos and illustrations on some pages, 271 pages, adults Speculative evolution • After man- a zoology of the future, D. Dixon, 1981, english, colorful illustrations on every page in the style of a nature guide, 119 pages, middle school+ • All yesterdays, J. Conway, C.M. Kosemen, D. Naish, 2012, english, colorful illustrations on all pages, some skeletal diagrams, 97 pages, middle school+¹ 1: haven't read it completely 2: English version also available 3: page count from amazon (a friend of mine has those books right no), all other page counts exclude the appendix/references/etc Age range is a very rough guess because a) I don't have kids, b) it's been a while since I was a child, c) we have a different school system (I used it roughly as pre school= under 6; elementary = 6-10, middle school = 12 ish, high school = 16ish, adult 18+) Sorry that so many of them are in german |
2024.05.18 12:27 Apodiktis Turning nouns into verbs with specific conjugation
2024.05.18 07:37 LordNikky rn everythings going wrong in my life
2024.05.18 05:42 mycoaching Explore Sanskrit Grammar: A Path to Linguistic Mastery
Sanskrit, often hailed as the language of the gods, is not only the root of many Indian languages but also a treasure trove of ancient knowledge and wisdom. Its precise and scientific grammar structure has fascinated scholars for centuries. In this article, we will delve into the fascinating world of Sanskrit grammar, exploring its key elements, significance, and the best resources for mastering this classical language. submitted by mycoaching to u/mycoaching [link] [comments] https://preview.redd.it/231w92pwv31d1.png?width=1920&format=png&auto=webp&s=9339abe2f0dc725060fe80d356a53b2a215534b5 The Significance of Sanskrit GrammarSanskrit grammar, known as Vyakarana, is the most detailed and systematic grammatical framework among the ancient languages. Composed of various intricate rules and structures, it offers unparalleled clarity and precision in communication. Understanding Sanskrit grammar is essential for accessing and appreciating the vast corpus of literature, philosophy, and science written in Sanskrit.Key Components of Sanskrit GrammarTo truly grasp Sanskrit, one must familiarize oneself with several fundamental components:
Tips for Mastering Sanskrit Grammar
Your Ultimate Resource for Sanskrit GrammarFor those looking to dive deep into Sanskrit grammar, My Coaching offers a comprehensive platform tailored to learners of all levels. From detailed explanations of grammatical rules to practical exercises and expert tips, My Coaching is designed to support and guide you on your journey to mastering Sanskrit.ConclusionEmbarking on the journey to learn Sanskrit is a rewarding endeavor that opens up a world of ancient wisdom and linguistic beauty. By focusing on the core components of Sanskrit grammar and adopting effective learning strategies, you can achieve proficiency and appreciation for this timeless language. For a structured and supportive learning experience, explore the resources available at My Coaching. Happy learning! |