Ever since I increased my dosage of Lamotrigine (Lamictal), I constantly feel like I'm wearing a headband? It's just, like, a gentle squeezing around my forehead, down the back of my skull (base of my neck), and behind my ears. Is this a common experience?

Hi, I recently upped my dosage to 200 mg and I had a bad experience with a few bugs in my room three days ago. Ever since then, I’ve been feeling them on me at all times, as well as seeing them everywhere. I look very closely and they disappear. I also keep seeing weird gray things peeking out of the shadows at night. I can’t really sleep, I’m very scared, because I haven’t had hallucinations since I was around 13, and I literally convinced myself that it was fake and never happened but now I’m not so sure. If it adds anything as to maybe why I am experiencing this, I stopped my lithium cold turkey (that I’ve been taking since 13)because I didn’t want to take it anymore because I convinced myself it was useless. Do you think that possibly lamictal is causing this or do I actually have hallucinations that lithium was helping with? I’m kind of lost right now, but lamictal has already cause me many issues so I started tapering off of it today. I’ve already emailed my psychiatrist, but I was wondering if people also had hallucinations on lamictal or if was me stopping the lithium that cause them again.

Methylene blue, renowned for its efficacy in treating methemoglobinemia, harbors a plethora of medical utilities beyond its conventional usage. This article delves into the multifaceted world of methylene blue, exploring its diverse indications, recommended dosages, and potential side effects to foster optimal patient care and safety.
Indications for Methylene Blue
While primarily employed for methemoglobinemia, methylene blue extends its therapeutic reach to several off-label applications. Noteworthy indications include mitigating post-injection pain during propofol administration, combatting chloroquine-resistant Plasmodium falciparum malaria, and averting ifosfamide-induced encephalopathy. Moreover, it aids in identifying parathyroid glands during surgical procedures, showcasing its versatility in clinical settings.
Mechanism of Action of Methylene Blue
Methylene blue's efficacy stems from its intricate mechanism of action:

• Restoration of Hemoglobin Function: By reducing oxidized hemoglobin, methylene blue reinstates its oxygen-binding capacity, pivotal in treating methemoglobinemia.
• Vascular Regulation: Inhibiting enzymes like endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase (iNOS), methylene blue facilitates vasoconstriction, regulating blood flow and pressure.
• Antimalarial Activity: Vital in combating Plasmodium falciparum, methylene blue reduces resistance to chloroquine and inhibits glutathione reductase, amplifying susceptibility to treatment.

These multifaceted actions underscore methylene blue's efficacy across various medical domains.
Administration of Methylene Blue
Typically administered intravenously, methylene blue dosage and regimen vary with the indication:

• Methemoglobinemia Treatment: A recommended dose of 1 mg/kg of a 1% solution, infused over 5 to 30 minutes, ensures therapeutic efficacy.
• Lymph Node Mapping: Utilized as a dye, intraparenchymal administration doses of 2 mL and 5 mL of a 1% solution facilitate precise mapping.

Adherence to prescribed guidelines by healthcare professionals ensures optimal therapeutic outcomes tailored to individual patient needs.
Adverse Effects of Methylene Blue
While efficacious, methylene blue usage warrants vigilance owing to potential adverse effects:

• Bluish-green Urine Discoloration: Benign and transient, urine discoloration may occur post-administration.
• Limb Pain: Intravenous administration may evoke mild limb discomfort, typically tolerable.
• Serious Adverse Effects: Caution is warranted to avoid serotonin syndrome, CNS-related symptoms, and neonatal complications, including hyperbilirubinemia and respiratory depression.

Methylene blue usage is contraindicated in individuals with hypersensitivity reactions or glucose-6-phosphate dehydrogenase deficiency, necessitating careful monitoring and prompt intervention if adverse effects manifest.
Conclusion
Methylene blue emerges as a versatile therapeutic agent with a spectrum of medical applications, transcending its conventional use. Understanding its indications, mechanisms of action, administration protocols, and potential adverse effects is paramount for ensuring safe and efficacious patient care. Collaboration among healthcare professionals facilitates optimized methylene blue utilization, enhancing patient outcomes and fostering holistic well-being.
📋 Source: Methylene Blue: Benefits, Dosage & Side effects

Does anyone know the highest dosage that someone should have for lamictal?
I had a tonic seizure in November and he suggested upping lamictal because my levels were on the lower side. I've had three accidental over doses so I was nervous to take to much because I don't want my liver problems to be worse. We upped vimpat instead and I went almost 5 months without one. I had a tonic seizure last month and one tonight before I took my pm meds. So I'm thinking he might suggest upping lamictal again. I take 800mg a day. 400mg at morning and 400mg at night. I don't want to try another medication. I was on kepra for a little and it made me really tired. I googled it but I couldn't find any answer.

hi, i’m 2 days on lamictal. so far, the only uncomfortable physical side effects are i sweat a little bit more than usual, i get a little dizzy after moving around, and i’m a bit more sensitive to bright lights. my dosage is 25mg but i’m sure my psychiatrist intends on increasing it.
i plan on working as a camp counselor this summer, but i worry that this medicine will make that more difficult for me to do. i’m just concerned and want to see some opinions, and/or some advice on how to take better care of myself better during the heat if it is an issue.

I struggle with medication compliance. I also have extremely disordered eating and body dysmorphia. **I hope this isn’t taken down because I’m not asking for med review or advice on dosage My psych is dead set on keeping me on lithium but everytime I start it I feel bloated and I start getting obsessed about weight gain. However, it significantly helps my mood and paranoia. I would like to try and stay on so I’m wondering if anyone has any positive experiences with Lithium they can share. I’m also taking Lamictal.

A new patient(F45) mildly obese was brought in who was planned for ECT in a week. Though she might actually be bipolar (atleast on the spectrum). She was terrified of ECT.
She had severe depression including suicidality and severe agitation.
She was on Lithium 600mg/day (Started recently), Lamotrigine 200mg, Lexapro 20mg and clonazepam 1mg with quietiapine 50mg for sleep.
Since 2023 she'd been experiencing strange episodes according to her family.
Here's all the history and symptoms provided about these episodes since 2023 :

• Agitation/Inner restlessness: Unable to remain calm/sit still. Blaming all of her symptoms on this restlessness. When this comes the other symptoms which I'll mention come along too:
  
• Crying and shouting loudly (simply can not control this to sorta escape)
  
• Excessive anger and snapping at/blaming others for no reason: Involuntarily blame people for the most random and petty things who've been the most helpful and kind.
  
• Very Irritable.
  
• Suicidality (to escape the restlessness). Suicidal attempts in aggression where she had to be stopped with a lot of physical force.
  
• Guilt and worthlessness
  
• Irrational/Questionable decisions and behaviors were almost always noted by family members during these periods accompanied with extreme impatience.
  
• Energy: Being fatigued and unmotivated that she can't even move or do stuff. But at the same time having so much Energy to shout so loud and rip her chest open to escape the "agitation".
  
• Pupils were dilated when I saw her.
  

After her lexapro was increased to 20MG her symptoms have been just worsening and worsening including suicidality.
Benzos would do nothing even injectable ones for the agitation.
Then today when she came to me during the severe agitation I immediately thought of a mixed state. Gave her zyprexa and asked to taper down the lexapro.
After she took the zyprexa (sublingual) in about 2 hours experienced tremendous relief - felt calm, brain went silent and took a long nap quite refreshing. She wasn't bothered by people talking. She wasn't irritated. She just felt normal. The relief seemed never-ending.
It makes sense now how being put on lamictal back in 2023 put her into remission and it kept masking Lexapro's rebound effect(in bipolar)
I'm honestly unsure why high dose Lexapro was continued over a year (even though there was a clear worsening of symptoms with dosage increase) and why high dose benzodiazepines were constantly being used to control the agitation despite having little to no effect. Even effexor was started in cross-titration with Lexapro which further worsened her suicidality etc?
Sorta leaning towards ECT and later on adjusting the medications because it does seem to be severe and ECT it is quite effective though the patient wants to try the no-ssri approach.
If we do go with the latter approach, I plan on : - Switch to Vraylar for its good evidence in mixed states. Cariprazine is dirt cheap here.

• Stick to Lamotrigine and increase Lithium/ Switch to Valproate(Good evidence in mixed features).
  
• Wellbutrin for depression if it does not or only partially responds to psychotherapy.
  
• Gabapentin.
  
• Low dose Trazodone for insomnia.
  

Perhaps the increased energy from the (hypo)mania and the activation from the SSRI is resulting in the restlessness which explains the relief from Olanzapine. I've seen many hypomanic patients who'd get so restless that they wanted to crawl out of their own skin.
What's your go to treatment for mixed states? What about the efficacy of Lithium in mixed bipolarity? Which mood stabilizers seem to work best?

I was on Lamictal 100mg for 4 months. It didn’t give me any side effects at 25 or 50 but after we upped the dosage to 100 I started getting weird side effects. Like my head was itching 7/24 and I suddenly got dermatitis on my scalp. But most importantly I was gasping for air all the time. Also I was yawning all the time. The breathing issue was so bad it was waking me up from my sleep. I couldn’t walk for like 10 minutes without gasping for air like a fish. We did all of the tests and everything was ok. After 4 months I stopped taking it and my symptoms magically disappeared. But months later I started having minor issues with my breathing. It is definitely not bad as the months ago when I was using the Lamictal but still it scared the shit out me because I can’t go through this again. Is it possible that Lamictal made something to my brain permanently that affects my breathing? I also started lithium 8 days ago but my I think it has nothing to do with it.

I am very curious to understand more about your journey with Lamictal. What was your dosage titration like? Do you feel like it's the right dosage? Any side-effects both positive and negative? I could go on and on with questions but I imagine you understand.
Personally I was introduced to Lamictal after Seroquel was not handling the depressive episodes. I was told Lamictal would help fill that gap. It's been a very interesting journey. For example, I've never had a "psychotic" episode prior, but that isn't all bad. Mostly just auditory hallucinations and losing time. One of the tougher side effects is dreaming. Everything is so insanely vivid that I have to go back through my emails/texts/etc to have some idea what really happened and what was imagined. It has led to some awkward conversations. The most notable effect has been the ability to feel. I know I'm part zombie at this point and I don't care.
Just curious about your journey. Feel free to message me if you want to talk more specifically about meds and dosages.

I was on Lamictal 100mg for 4 months. It didn’t give me any side effects at 25 or 50 but after we upped the dosage to 100 I started getting weird side effects. Like my head was itching 7/24 and I suddenly got dermatitis on my scalp. But most importantly I was gasping for air all the time. Also I was yawning all the time. The breathing issue was so bad it was waking me up from my sleep. I couldn’t walk for like 10 minutes without gasping for air like a fish. We did all of the tests and everything was ok. After 4 months I stopped taking it and my symptoms magically disappeared. But months later I started having minor issues with my breathing. It is definitely not bad as the months ago when I was using the Lamictal but still it scared the shit out me because I can’t go through this again. Is it possible that Lamictal made something to my brain permanently that affects my breathing? I also started lithium 8 days ago but my I think it has nothing to do with it.

I need something that will do what it did that doesn't contraindicate with Seroquel.
Anxiety is all time back with a side of nasty mean voices bombarding me with imposter syndrome and just anger. Every bit I was able to shift out of my system for the last five months is back.
I'm wondering - Lamictal helped with the angry before...can't go back but is there something new to stop this?
(Update - I won against the voices. Made it to graduation. Was not an imposter. I belonged. Saw some great kids graduate. All the voices were wrong and so they shut up.)

i started wellbutrin 8 weeks ago and two weeks ago we upped the dosage to 300mg.
it’s been….a journey. after upping the dosage, i got the side effects such as big paranoia, anxiety and mood swings but i expected it since that’s how my first week on it was.
however now, i am just crying all the time? and i feel soso low and it feels as if i am unmedicated. i also take lamictal which is great. i just needed meds to focus and to be productive and i don’t know if i should call my psychiatrist and ask if i can stop or? i don’t feel great honestly. my emotions are everywhere and i instantly get sucked into a full on depression? but it’s not like depression? i don’t know how to explain it.
did someone have similar experiences?

I am currently on a low dose of lamotrigine (generic version of lamictal) and have been taking it since December of last year. We had to work slowly to increase my dosage bc moving too fast caused increased suicidal thoughts and irritability.
At first I felt like I was making progress and my moods started to feel less extreme between highs and lows. But lately I am feeling as if the meds are not doing anything for me at this point, other than feeling more heightened anxiety and tiredness. However, my psychiatrist said the anxiety could be stemming from other life situations I have going on. I am just not sure which it is.
So she recommended maybe switching to Latuda, if anyone has experiences on this med if you can share your thoughts/how it’s worked for you?

Hi, so quick question. I've been on a low dosage of lamictal for almost a year (in conjunction with Ativan and tegretol that I've been on for eons), however, I've noticed some bruising on my chest and arms. Has anyone else experienced this? Should I make a doctor's visit?

hiii.. cant believe this is the only sub im active on LOL
umm i've been on 200mg lamictal forrrr... 2 weeks? can't remember. i told my psych and he said we weren't going to keep taking it since it hasn't been helping me since i took buspar for 2 weeks (messed everything up); didn't say anything about titrating (is that the right word?)
i've read that stopping cold turkey at a high dose is a bad idea. unfortunately, i don't think i can lower my dosage myself. i don't think i have 150mg, but i know i have 100 and maybe 75?
i've also read that it could induce the risk of seizures n other side effects. so i'm absolutely terrified. so i don't think i'm gonna stop taking my lamictal until i absolutely run out.
has anyone stopped cold turkey at a high dosage?? if so, what was your experience?? any advice would be appreciated :(

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The Complete Guide to Tesamorelin: Mechanism, Benefits, Precautions, and Dosing

Tesamorelin has emerged as a significant player in the realm of peptide therapy, particularly for individuals looking to combat the effects of aging and improve body composition. This guide delves into the science behind Tesamorelin, exploring its mechanism of action, proposed benefits, necessary precautions, and a sample dosing schedule to provide a comprehensive overview for those interested in this potent peptide.

Mechanism of Action

Tesamorelin is a synthetic analog of the human Growth Hormone-Releasing Hormone (GHRH), designed to stimulate the pituitary gland to release growth hormone (GH). By mimicking the natural GHRH, Tesamorelin binds to the GHRH receptors in the pituitary gland, leading to an increase in the production and release of endogenous GH. The elevated levels of GH then exert their effects on various body organs, primarily promoting lipolysis (the breakdown of lipids) and leading to a reduction in triglycerides levels.

Proposed Benefits

Fat Loss and Improved Body Composition: Tesamorelin has been shown to significantly reduce visceral adipose tissue (VAT), which is closely associated with increased cardiovascular risk and metabolic diseases.
Enhanced Cognitive Function: Some studies suggest that Tesamorelin could potentially improve cognitive function among older adults and those with early signs of cognitive decline.
Muscle Strength and Function: While primarily known for its fat-reducing properties, Tesamorelin may also contribute to muscle strength and function due to its role in stimulating GH production.
Cardiovascular Health: By reducing VAT and potentially improving lipid profiles, Tesamorelin can contribute to better cardiovascular health.
Joint Health and Flexibility: Tesamorelin promotes collagen synthesis and enhances joint lubrication, supporting joint health and flexibility.

Precautions

Before using Tesamorelin, it's crucial to consider the following precautions:

• Pregnancy and Breastfeeding: Tesamorelin is contraindicated in pregnancy due to potential harm to the fetus and should be avoided by breastfeeding mothers.
• Cancer History: Individuals with a history of cancer should consult their healthcare provider before using Tesamorelin, as GH can potentially stimulate the growth of cancerous cells.
• Allergies: Those allergic to Tesamorelin or any of its components should avoid its use.
• Pre-existing Conditions: Patients with kidney or liver problems, diabetes, or pituitary gland disorders should use Tesamorelin with caution

Sample Dosing Schedule

A typical dosing schedule for Tesamorelin for the purpose of reducing VAT in HIV-associated lipodystrophy, as per FDA-approved guidelines, is as follows:

• Dosage: 2mg of Tesamorelin per dose.
• Frequency: Administered as a subcutaneous injection once daily before bed.
• Cycle: 5 days on, 2 days off.
• Duration: 20-52 weeks, depending on the individual's response and goals.

Administration Tips:

• Inject Tesamorelin under the skin in the abdominal area, avoiding areas with scar tissue, bruises, or irritation.
• Rotate the injection site to prevent issues with over-injection in one area.
• Ensure to administer Tesamorelin at least 90 minutes after the last meal to enhance its effectiveness.

I am currently on 100mg. ever since i titrated up to 75mg i’ve had this feeling of angst and just feeling uncomfortable or not normal in my body. when i started and when i titrated to 50mg i experienced this but only for a few days, but ever since i’ve been on 75mg it seems to have not gone away. I do have a lot going on in my life currently, and my therapy sessions have been really deep the last few weeks, uncovering and working through some trauma. it’s kind of hard for me to determine if the feeling of uneasyness and anxiety are from life events or from the medication. i have an appointment with my provider soon, and i’m kind of nervous to up my dosage because i’m already feeling pretty anxious, and have also noticed some physical things that are concerning me. i also understand that i’m not really at the “therapeutic” dose yet, so the full affects of the medication may not be there. our last appointment i was manic and she mentioned to me taking another medication for my mania/anxiety because lamictal doesn’t focus on that. i don’t think i’m really comfortable with adding another medication on right now. any recommendations? has anyone else experienced this and the feelings subsided with higher dosage/time ?? anything helps!

If your Neurologist starts you out on anything higher than 50mg, SAY NO! Starting Lamictal at a high dosage can be fatal due to the extremely high risk of Rash... Lamotrigine is meant to be a ramp up drug... Such as 25mg for 2 weeks, 50mg for 2 weeks, 100mg for 2 weeks, and then if needed, 200 mg or higher going forward... This drug has to have a built up presence in your blood/liver... Hitting it at 100mg immediately is almost certain to cause major issues.

So I was thinking about this today I only have one friend who is also epileptic and when I was talking to her about medication she said something I found interesting she said both kepra and lamictal (lamotrogine) increased her seizure activity. I was on lamictal at the highest dosage and it was having no control over my seizures then recently I was told to take kepra and lamictal together and had an extreme increase in seizures to the point of not being able to go anywhere. And it surprised me to hear she had a similar experience. I'm wondering if anyone else has had this problem?

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I was infected in April 2024 in Thailand after unprotected sex.

Believing it was gonorrhea (identical symptoms) I took azithromycin. 1 mg in 4 capsules (4x250mg) the first day then 500 mg (2x250mg) per day for 4 days. Small temporary improvement but still the symptoms are present (burning sensation when urinating, whitish discharge from my penis, internal tingling and external redness, small rise in fever approximately every 3 days).
Thinking of gonorrhea, the doctor prescribed an intramuscular injection of CEFTRIAXONE 1g in the buttock: no improvement.
Sampling the discharge from the surface of the urethra (not inside) in the laboratory to determine the bacteria. Sample taken in the morning before urinating: by squeezing my penis so that the whitish discharge comes out.

Analysis result: Mycoplasma genitalium with A2058G mutation

This mutation explains the resistance to the antibiotic.
The doctor prescribed me moxifloxacin (400 mg per day for a week) but I decided not to take it because the overuse of antibiotics disrupts the microbiota and has significant side effects). In other parts I read that bacteria adapt to antibiotic medications but cannot adapt to certain antibacterial essential oils. Since essential oils have different complex components that bacteria cannot overcome. After numerous conferences on the subject (internet and books) I decided to take on the challenge of putting my conferences to work in order to see if they were true.

Here is the detail of the synergy that allowed me to eradicate this bacteria:

One week before treatment: use of garlic powder in capsules. 4 capsules per day: total dosage for the 4 capsules: 1200mg of organic garlic bulb powder (sulphites).
Contraindications noted on the box of this food supplement : Not recommended for people on anticoagulant treatment.
Garlic is a sulfur compound capable of undermining the communication of bacteria with each other. In other words, garlic will not eradicate the bacteria but it will prevent it from proliferating by scrambling their communication system. I finally felt a positive effect because the discharge of pus stopped. The burning sensation when urinating has not disappeared but it has significantly reduced.
This treatment will allow the essential oils to act more effectively.

1. Synergy that I used internally orally (in capsule form) especially not pure :

I used a 10 ml bottle:
Thyme essential oil with organic thymol (hepatotoxic): 12 drops
Organic compact oregano essential oil (hepatotoxic): 12 drops
Organic Lemon essential oil: 12 drops (protects the liver)
Organic Rosemary verbenone essential oil: 12 drops (protects the liver)
Organic Ceylon Cinnamon (bark) essential oil: 12 drops
Organic Tea Tree essential oil: 12 drops
Organic clove essential oil: 12 drops
Organic Nigella (black cumin) vegetable oil: 126 drops
I filled this synergy in empty capsules (purchased on the internet) of size 0 which can contain 13 drops (0.5 ml). Be careful not to absorb these essential oils directly without a capsule because some of these oils are very irritating to the skin and even more so to the mucous membranes. The bottle will be empty before the end of the treatment, the synergy will have to be redone once the bottle is emptied to complete the 7 days
1ST day: 6 capsules to be spread over the day.
2nd day: 6 capsules to be spread over the day.
3rd day: 6 capsules to be spread over the day.
4th day: 5 capsules to be spread over the day.
5th day: 5 capsules to be spread over the day.
6th day: 4 capsules to be spread over the day.
7th day: 4 capsules to be spread over the day.

2. Synergy that I used externally (to massage on the lower abdomen morning and evening). To be done at the same time as the synergy by oral voice.

Organic Ceylon Cinnamon (bark) essential oil: 3 drops
Organic clove essential oil: 3 drops
Organic compact Oregano essential oil: 3 drops
Organic Nigella (black cumin) vegetable oil: 3 large spoons
For my part, it was only from the 4th day that I felt the effects of the bacteria disappear, but however it is important to continue until the 7th day of treatment.
Hope this helps and works for yourself.