https://www.croiconference.org/abstract/persistence-of-sars-cov-2-in-platelets-and-megakaryocytes-in-long-covid/
Publication mentions that, in long Covid patients, the precursors to platelets, megakaryocytes, which are formed in the bone marrow, are infected with sars Covid. The infected platelets, when released from bone marrow, can travel throughout the body and can cause a myriad of problems, from the heart, to brain, to vascular system.

I don’t know where to start with this. There is so much and I’m pretty sure this is above reddits paygrade. I just don’t know where to turn too. I (38f) have been with my fiancé’ (38m) for almost 4 years now. I love him but I think I want out of the relationship. I can’t imagine being with someone else but I also cant imagine doing this for my entire life. There is so much to go over but I’m pretty sure at the end of this I am a huge double triple huge asshole for how I feel. I won’t make excuses. All I’ll say is that this has been happening long before we got to here. There is a lot of context but the first thing I guess I should address is that we both have chronic health issues. His is much more life threatening if not maintained but for the most part is healthy. He rarely gets sick but when he does it’s pretty bad. He has a rare form of anemia that is only treatable by lifelong steroid use or bone marrow transplant. I always keep up with his health and his hemoglobin levels are good but I don’t schedule his apps or attend all visits. He does all that. About a year and a half ago transplant talk was put on the table and he was vehemently against it. But after about a year he realized there wasn’t a choice his meds aren’t working anymore. I’ve always asked if hes in pain or struggling he makes it very clear he is fine and that he would tell me if he wasn’t. I am super aware of when things look off, or if he looks really pale. I always ask questions and when I do go to the doctors apps I pay attention.
I have an autoimmune disorder. It varies from being annoying as fucking hell to down right painful and I can’t walk. He has been less than sympathetic to just down right making fun of me. He’s told me I need to live in a bubble to you’re always sick, to what doesn’t hurt on you. Not much dude. Not much. To be clear I don’t whine, I don’t miss work unless is unavoidable, I went to work with Flu A, B and covid before I almost out right couldn’t set up. I’ve had full blown asthma attack on the bed and in-between breathes asked for him to get the nebulizer because I didn’t have a rescue inhaler anymore. My daughters cat laid on me because I was so sick and doing the treatment and while most cats love me, I’m not this cats favorite but even he was like mom needs me. He looked annoyed and thought I was being dramatic. It wasn’t until the doctor told me I was super mega sick that he relented. Im on immunosuppressants and I have two small school age kids who are walking petri dishes, I catch a lot. Its not for a lack of trying no too. One of the biggest I have a bad tendency to get yeast infections, its chronic and not entirely unavoidable. Sex is a huge factor in this and it’s a snow ball effect, it starts with a yeast infection that blooms in to a full on UTI then my lichen Sclerosis flares, and lots and lots of sex exacerbates these issues. He likes to bring up the first year we were together that we had a lot of sex but we didn’t live together and had to many days apart. I spent 100s of dollars on yeast meds and suppositories. I still ended up in urgent care for a UTI that caused a fever so high they were convinced I was septic. I wasn’t but I felt super awful. When we moved in together the sex things seem to bother him more. He had issues with all the things wrong and I tried to explain and give him things to read but it seemed to fall on deaf ears. We fought about it constantly. We had full blown arguments over sweatpants and sexy clothing. To when he actually told me unless I wore sexy panties sex didn’t matter to him. He apologizes after but I know that he meant what he said. I’ve never lied to him about any thing, I’m not an overly sexual person and not usually open about being attracted to someone but I have tried to meet him halfway. I knew my illness was causing a lot of problems so I tried so hard to be better. I had gained a lot of weight from steroid use so I went and got help to loose the weight, Ive lost like almost 80lbs. Ive gotten down to only one suppressant medication. But the skin issues still linger. I was told there wasn’t much I could do about it. I’ve gone to the doctor multiple times just for this issue. I’ve tried supplements and boric acid suppositories. Its helped but not enough to really notice. We just had to make changes to the way we have sex, we are still having it 2-3 times a week but we have to have days in-between and we have to minimize sperm contacting my skin. I was also diagnosed with seminal plasma hypersensitivity which is common with my skin disorders and it is an allergic reaction. But I have to put a huge wall up for spontaneous sex which is a huge bummer and he is 100% reliant on me being the one that’s spontaneous. Which he doesn’t think is fair. I understand all that but I’ve explained if sex hurt him or caused the issues I’ve had you’d understand why I have to do it this way. There have been times where I’ve had issues and had to abstain for sex or a week but It’s never been much longer than that and he’s constantly asking if its better or if we can do it. He rushes care and a lot of times I’m reinfected or I just never went away cause its never had time to heal. The only time he doesn’t press as bad is when I’m on my period and even then he makes comments about putting a towel down. He talks about sex constantly, asks for blow jobs when I can’t and insists on trying to lick me when I’m not in the mood. When someone has a yeast infection they aren’t thinking about anything going anywhere near this vag, they are uncomfortable and wished they could rip it off and throw it away. I have counted how many times hes brought up having sex in an hour and the most he’s done it is 23 times the least is 8. He can’t have a conversation with me without bringing it up. I could be talking about something completely different and he’ll go we doing it today? Completely off topic. ITs so much worse now that hes going to have to have transplant and has to go at the very least 30days with out sex. The first questions he asked whenever this was happening had nothing to do with will I live it’s been when can I have sex? He’s willing to risk my health and his health for it. I just can’t anymore. His main concern this entire time is don’t find someone else and don’t fuck anyone else. Not I love you and all of our kids, its’ been just about this and that he’s going to be ugly after the transplant. To which I could give a fuck about. I want to be clear I love him, I love having sex with him but this is just really hard to deal with. I’ve tried talking to him Ive tried expressing that this isn’t normal. He gets super defensive that why are you in a relationship for if you aren’t going to touch them and the entitlement to just grab at me has more than once sent me on edge. I’ve tried to explain it just devolves into fight where he just shuts down and says I just won’t fucking touch you period. Then spins it as I’m the one making a big deal. Its just sex.
These aren’t the only issues, we both have children from previous relationships my kids are much younger and hes jealous of the attention they get, hes so worried about me and him he doesn’t even pay attention to his own kids who are now teenagers. During this whole transplant talk hes made comments that he can’t wait to be alone and have a break from work and no kids around. His kids have heard him. All 4 are taking this super hard, he doesn’t care, he just says my kids are clingy and can’t do anything on their own. My kids are 7 and 5. I can go into more details but this would be so effing long if I did. And to be clear about this he has had these behaviors probably for the past 2 years way before we had the transplant conversations.
I know that I’m supposed to be one of his carers after the transplant. His mom will be primary as I am the main caregiver of my bio children and he will be located about 3 hours away. We were gone to testing this week and things were pretty fun we played and best friend game and for once no topics of sex came up. And it was like I got a glimpse of the person I fell in love with. But the next day it was right back to talking about sex every time he looked at me. When were seeing doctors, I had to excuse myself at one point because I realized if the roles were reversed he wouldn’t do this for me. If I lost any part of my beauty or ability to have sex this would be over. IT was so sobering and I was devastated. I tried talking to him when we got home and it caused a fight that we are still currently in. He says I’m not interested in sex every and he doesn’t try anymore cause Im never in the mood. Ive explained that constantly talking about it ruins it. Ive showed him time and time again if you just stop you get more from me. He doesn’t care. I don’t want to be his carer anymore. And I know that makes me a horrible person. Please excuse typos I am on voice text.

Hi!
I have been preparing bone broth for the last few months using Instant Pot's Slow cooking mode.
I usually keep it on LOW for 18-20 hours. The bones are also cut into smaller pieces.
But when i check the bones after 18 hours, most of the marrow is still inside the bones. I assume it should come out right ?
What should I be doing here ?

I just did a bone marrow butter however it is more liquid-ish than buttery-ist does anyone know why?

Hello, my PitBull X Coonhound is 13 mounts and currently a service dog and passed all ADA public access test. About 2 years ago I was diagnosed with cancer that spread to my brain and relapsed several time within the last year when I got him.
Ive been through chemos AND a bone marrow transplant with my dog when he was a puppy and he’s truely glued to my side when sick.
At about 10-11 months he became extremely reactive to his kennel downstairs and refuses to sleep anywhere but in bed with me directly next to me BETWEEN my Gf and I. Also spends most the time sitting and watching the door. I’m currently roughly 7-8 months cancer free and much healthier now so I’m not sure why he’s still acting this way and we are fighting in the bed with him every night. (I was probably about 5 months cancer free at the time he started)
Looking for advice from people who don’t want to forcefully remove their dog from their room (being he’s a service dog and he has task he performs at home and not many public access task) but also want room and move legs and sleep freely.

Normally I pop it in the oven, then spread on toast or crumpets. Just wondering if there was a better way.

Living long enough almost inevitably brings you face-to-face with cancer, with the lifetime risk of developing it nearing 20%.
In 2022, nearly 20 million new cases of cancer were reported worldwide, with 9.7 million people dying from the disease.
While the United States is often viewed as a frontrunner in cancer care, its cancer death rate does not significantly surpass global standards. The U.S. cancer death rates are lower than in certain developed nations but align with China's and exceed those of Brazil, India, and Indonesia—three emerging countries.
When considering age adjustments, most countries globally generally report cancer death rates ranging from 80 to 100 per 100,000 individuals, with minimal variations between nations, except for India, which is slightly lower.
For cancer patients in the U.S., even with access to advanced medical care, substantial health insurance, and the latest anti-cancer drugs and technologies, their survival time may not be longer than that of patients in China who are treated with the most cost-effective medications.
When a cancer patient visits a hospital, the doctor will offer the following treatment options: Surgery, Interventional Therapy, Chemotherapy, Radiation Therapy, Bone Marrow Transplant, Immunotherapy, Hormone Therapy, and Targeted Drug Therapy.
With hundreds of cancer treatment methods available, theoretically, there is always one that might suit you, but sometimes having too many options can feel overwhelming.
In cancer research, researchers often pursue complex technologies, while in clinical diagnosis, there is a tendency towards overtreatment. This can be seen in clinical guidelines and doctors' preference for short-term effective treatments, overlooking long-term negative impacts such as side effects, drug resistance, and unsustainable therapies.
Cancer treatment limitations, which significantly impact patient care, stem from the following four factors: Traditional Views Factors; Healthcare System Factors; Physician Factors; Patient Factors.
Traditional Views Factors: Early detection and treatment lead to overtreatment. Advanced technologies do not necessarily yield long-term effects. High mortality rates undermine patient confidence.
Healthcare System Factors: Treatment plans do not target long-term patient benefits. Standard treatments limit individual choices. Strict regulations hinder innovation.
Physician Factors: Tendency to overtreat under standard treatment protocols. Significant decision-making power, but treatment choices are random. Long-term patient benefits are often overlooked in treatment decisions.
Patient Factors: Patients seldom participate in decision-making, overlooking true goals. Fear of cancer impedes clear understanding. Lack of proper standards for evaluating treatment options. Patients must change their mindset and learn new ways of thinking to improve their cancer treatment outcomes.

Had a delightful evening at Delta, a new-ish tasting menu in Athens. It’s housed in a beautiful campus that includes the national library and opera house. The restaurant is gorgeous, with trees in large planters that hang from the ceiling. Service was kind and knowledgeable, and servers seemed excited to share the dishes. It’s a very experimental menu, with both Nordic influences and a lot of tromp l’oeil. The ingredients use mostly local Greek produce and the restaurant highlights their goal of sustainability. All of this leads to major Michelin bait. Good thing is that while some dishes didn’t do it for me, on a whole it was a delicious experience, with some very novel techniques. Even the dishes that weren’t to my taste were interesting and showed reach for the kitchen, and the reasons I didn’t enjoy them came down to mostly personal taste. The dishes that did hit were absolutely delicious and wildly creative.
Courses were as follows:
1) a mushroom and nut tartar flavored with chamomile on a crispy cabbage base: strong start with a tasty amuse that had some deep chamomile flavor that read purely savory 2) Second course was a fake Calla flower filled with confit pigeon leg and topped with bergamot foam- wildly delicious with fresh citrus mingling with savory meat and the “flower” petal acting as a delightful base 3) Grilled deer covering fermented artichoke and fermented blueberry with oxalis flowers- interesting dish with lots of strong flavors- I would have loved it if not for the strong fermented funk that’s not my cup of tea- if you love lactofermented stuff you’ll love this 4) “Leaf” of dehydrated pear filled with grilled iberico pork and sprayed with pine- one of the most delicious things I’ve ever eaten, a textural and flavorful dish of light and meaty happiness- ate like a fresh but still savory delight 5) Grilled corn on fermented buckwheat- another knockout, this ate like the best corn on the cob ever, and the buckwheat base had a meatiness to it, like what seitan should be 6) Bread coarse was shaped like a porcini mushroom and flavored with aged vegetables, blackened apple, a variety of herbs and brushed with aromatics, served with a foamy bone marrow crème anglaise: another stupidly delicious course that was beautiful too- bread was intensely flavored and the bone marrow foam added even more richness, all tempered with this bright green dehydrated gremolata paste hidden underneath the “mushroom” cap. It tasted like the best pizza bagel I’ve ever had 7) Cod made to look like a scallop, with fresh flowers covering the orange “skirt”- the skirt was actually fermented and grilled plums- this was a good dish, very light, with good flavors off the cod, plums, and flowers- but felt like it could use a light more salt on the fish itself . Good but not amazing. 8) Sweetbreads covered with koji inoculated grains to look like a fuzzy bird- a really creative dish that looked amazing but was not to my taste. The mold was my favorite part, but the sweetbreads were way too heavy for me. 9) Possibly the best dish of the night for me- a slowly caramelized and dehydrated apple filled with picanha steak and covered in beef garum and Demi glace. This was mind blowing in that the apple had just as much meatiness as the beef with full apple flavor but no sweetness, so it tasted like a savory apple with just immensely deep umami. 10) Pigeon breast glazed with fermented cherry and berries with endive and a pigeon sauce- a nice final savory dish with good grilled flavor . Not mind blowing but certainly good 11) First dessert was a puffed sugar Mille feuille made to look like a sunflower, filled with a cream flavored with chestnuts, sunflower praline, and caramelized puff pastry- very tasty and a smart dish to use puff pastry to flavor the cream- was very tasty
12) final two desserts (one was a celebratory cake for my special occasion):
12a) the cake was fully edible (even the candle which was made of walnut oil). It was nice but could have had a bit more flavor and diversity of texture 12b) An edible butterfly, this was the best dessert. The wings were crunchy and acidic with a perfect snap and the body was light and creamy with a good acidity- as nice to eat as it was to look at. Was filled with beeswax cream and cherry.
Great meal overall!

~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD¹
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.^1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.^6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.

When your taste buds yearn for the mouthwatering flavor of a perfectly grilled steak, Hesperia, California, delivers like no other. This desert city may surprise you with its variety of steakhouses, each offering a unique twist on the classic steak dinner. Whether you're a local looking for a new favorite spot or a traveler passing through, these six top-rated steakhouses in Hesperia, California, in 2024 are sure to leave you craving more. Let's dive into these sizzling sensations and find out where your next steak adventure awaits!

1. Desert Flame Steakhouse

A Culinary Oasis

Nestled in the heart of Hesperia, Desert Flame Steakhouse is a beacon for steak lovers. Known for its rustic charm and warm atmosphere, this spot offers a dining experience that feels like a cozy retreat.

• Signature Dish: The Ribeye Special – a 16-ounce ribeye grilled to perfection and served with garlic mashed potatoes and seasonal vegetables.
• Ambiance: Rustic décor with wooden accents, soft lighting, and a roaring fireplace.
• Must-Try: Their homemade steak sauce, a closely guarded recipe that perfectly complements any cut.

Why We Love It

Desert Flame doesn't just serve steaks; it serves memories. The staff here treat you like family, ensuring that every meal is a memorable one. Plus, their wine list is top-notch, featuring selections that pair beautifully with their menu.

2. Sierra Peaks Steakhouse

Elevated Dining

Perched on the outskirts of Hesperia, Sierra Peaks Steakhouse offers more than just a meal—it provides an experience. With panoramic views of the Sierra Nevada Mountains, dining here feels like a special occasion every time.

• Signature Dish: The Filet Mignon – an 8-ounce filet wrapped in bacon, grilled to your liking, and served with a creamy mushroom sauce.
• Ambiance: Upscale with floor-to-ceiling windows, offering stunning mountain views.
• Must-Try: Their truffle mac and cheese, a decadent side dish that steals the show.

Why We Love It

Sierra Peaks combines breathtaking views with gourmet cuisine, making it the perfect spot for romantic dinners and celebrations. The attentive service and luxurious setting ensure that every visit is unforgettable.

3. Cattleman’s Grill

Down-Home Comfort

Cattleman’s Grill brings a touch of Texas to Hesperia with its hearty portions and laid-back vibe. This is the place to go when you want a great steak without any fuss.

• Signature Dish: The Cowboy Ribeye – a massive 20-ounce bone-in ribeye that's juicy, flavorful, and cooked to perfection.
• Ambiance: Casual and cozy with checkered tablecloths and country music.
• Must-Try: Their loaded baked potato, topped with cheese, bacon, and chives.

Why We Love It

Cattleman’s Grill is all about comfort food done right. The friendly service and relaxed atmosphere make it a favorite for families and groups of friends looking to enjoy a hearty meal together.

4. Pinnacle Steakhouse

Modern Elegance

For those who appreciate a modern twist on traditional steakhouse fare, Pinnacle Steakhouse is a must-visit. This chic eatery combines contemporary décor with a menu that’s both innovative and delicious.

• Signature Dish: The Wagyu Strip – a melt-in-your-mouth strip steak that's known for its rich marbling and buttery texture.
• Ambiance: Sleek and sophisticated with modern art and ambient lighting.
• Must-Try: Their bone marrow butter, which adds an extra layer of decadence to any steak.

Why We Love It

Pinnacle Steakhouse offers a fresh take on the classic steakhouse experience. The creative menu and stylish setting make it a great choice for date nights and special occasions.

5. Hesperia Chophouse

Timeless Tradition

Hesperia Chophouse is a local institution, beloved for its timeless approach to steakhouse dining. Here, tradition reigns supreme, and every dish is crafted with care.

• Signature Dish: The Porterhouse – a 24-ounce behemoth that's perfect for sharing, cooked to your exact specifications.
• Ambiance: Classic and elegant with white tablecloths and dark wood paneling.
• Must-Try: Their classic Caesar salad, prepared tableside for a bit of old-school flair.

Why We Love It

Hesperia Chophouse is where you go for a tried-and-true steakhouse experience. The impeccable service and attention to detail make it a standout in the local dining scene.

6. High Desert Steakhouse

Casual Excellence

Last but certainly not least, High Desert Steakhouse offers a laid-back environment with top-tier steaks. It's the perfect blend of casual dining and gourmet cuisine.

• Signature Dish: The New York Strip – a 12-ounce strip steak that's juicy and flavorful, served with your choice of sides.
• Ambiance: Relaxed and inviting with a friendly, down-to-earth staff.
• Must-Try: Their house-made chimichurri sauce, which adds a zesty kick to any steak.

Why We Love It

High Desert Steakhouse is all about great food without the pretense. It’s a fantastic spot for a casual dinner with friends or a relaxed family meal.

FAQs

What are the best steakhouses in Hesperia, California in 2024?

The six top-rated steakhouses in Hesperia, California, in 2024 include Desert Flame Steakhouse, Sierra Peaks Steakhouse, Cattleman’s Grill, Pinnacle Steakhouse, Hesperia Chophouse, and High Desert Steakhouse. Each offers a unique dining experience with delicious steaks and exceptional service.

Which steakhouse has the best view in Hesperia?

Sierra Peaks Steakhouse offers the best view, with stunning panoramic vistas of the Sierra Nevada Mountains, making it an ideal spot for a memorable dining experience.

Where can I find the most affordable steak in Hesperia?

Cattleman’s Grill is known for its hearty portions and reasonable prices, making it a great choice for those looking for a delicious yet affordable steak dinner.

Are any of these steakhouses good for special occasions?

Yes, Sierra Peaks Steakhouse and Pinnacle Steakhouse are particularly well-suited for special occasions, offering upscale dining experiences with elegant settings and exceptional menus.

Can I bring my kids to these steakhouses?

Absolutely! Places like Cattleman’s Grill and High Desert Steakhouse offer a casual and family-friendly atmosphere, making them great options for dining with kids.

Conclusion

Hesperia, California, may be known for its desert landscapes, but when it comes to steak, this city is a hidden gem. From the rustic charm of Desert Flame Steakhouse to the modern elegance of Pinnacle Steakhouse, there's a spot for every steak lover. So next time you're in town, treat yourself to a delicious meal at one of these six top-rated steakhouses in Hesperia, California, in 2024. Your taste buds will thank you!

I am a 32yo male who had a high grade high ankle sprain about a month before the MRI (report below). I hurt it doing Muay Thai when I had a bad fall on a slippery surface while sparring. History of Achilles tendinitis for several years with intermittent PT, previously an avid runner on both roads and trails. After over a month of resting, the ankle still remains swollen to the anterior and lateral sides. I am able to walk with moderate pain. Still limited dorsiflexion and external rotation of ankle, but balance on injured leg has improved slowly with PT. Would I require surgery? What would be the approximate timeline for returning to running/Muay Thai for either the surgical/non-surgical route? Thanks again for your input!
Report: Bones/joints: No displaced fracture or dislocation. There is edema-like signal within the mid lateral talar dome measuring 1.0 x 0.3 x 0.6 cm, with mild associated signal abnormality of the overlying cartilage. No full-thickness cartilage defect. Additional mild edema-like signal within the posterior malleolus. There is a trace tibiotalar joint effusion. Chronic ossific fragments anterior inferior the lateral malleolus, better demonstrated on comparison radiographs.
Ligaments: Anterior inferior tibiofibular ligament appears significantly attenuated and likely torn. Intermediate signal throughout the posterior inferior tibiofibular ligament. Chronic ossicles overlie the proximal anterior talofibular ligament, and the mid ligament is chronically torn with fluid interposed within the region. Mild thickening of the calcaneofibular ligament. T1 hypointense signal over the anterior syndesmosis and lateral ankle consistent with chronic capsular injury. Deltoid ligament appears intact. Mild thickening of the dorsal talonavicular ligament. Midfoot has normal alignment, and without marrow edema-like signal.
Tendons: Achilles tendon mildly thickened with intermediate T2 signal consistent with mild tendinopathy. No significant retrocalcaneal bursitis. Posterior tibialis and the flexor hallucis longus and flexor digitorum longus tendons are intact. Increased fluid around the peroneal tendons proximal to the retromalleolar groove. Extensor tendons are intact.
Sinus tarsi: Unremarkable.
Plantar fascia: Unremarkable.
Soft tissues: Unremarkable.
IMPRESSION:

1. Small area of marrow edema within the mid lateral talar dome with overlying mild chondral fraying. These findings may reflect a subacute versus chronic low-grade osteochondral lesion.
2. High-grade high ankle injury evident by complete tear of the anterior inferior tibiofibular ligament, with a moderate grade injury of the posterior inferior tibiofibular ligament.
3. Chronic lateral ankle injury notable for chronic tear of the anterior talofibular ligament. Clinical exam will be a better determinant of ankle stability.
4. Moderate tenosynovitis of the retromalleolar peroneal tendons.

I am a 32yo male who had a high grade high ankle sprain about a month before the MRI (report below). I hurt it doing Muay Thai when I had a bad fall on a slippery surface while sparring. History of Achilles tendinitis for several years with intermittent PT, previously an avid runner on both roads and trails. After over a month of resting, the ankle still remains swollen to the anterior and lateral sides. I am able to walk with moderate pain. Still limited dorsiflexion and external rotation of ankle, but balance on injured leg has improved slowly with PT. Would I require surgery? What would be the approximate timeline for returning to running/Muay Thai for either the surgical/non-surgical route? Thanks again for your input!
Report: Bones/joints: No displaced fracture or dislocation. There is edema-like signal within the mid lateral talar dome measuring 1.0 x 0.3 x 0.6 cm, with mild associated signal abnormality of the overlying cartilage. No full-thickness cartilage defect. Additional mild edema-like signal within the posterior malleolus. There is a trace tibiotalar joint effusion. Chronic ossific fragments anterior inferior the lateral malleolus, better demonstrated on comparison radiographs.
Ligaments: Anterior inferior tibiofibular ligament appears significantly attenuated and likely torn. Intermediate signal throughout the posterior inferior tibiofibular ligament. Chronic ossicles overlie the proximal anterior talofibular ligament, and the mid ligament is chronically torn with fluid interposed within the region. Mild thickening of the calcaneofibular ligament. T1 hypointense signal over the anterior syndesmosis and lateral ankle consistent with chronic capsular injury. Deltoid ligament appears intact. Mild thickening of the dorsal talonavicular ligament. Midfoot has normal alignment, and without marrow edema-like signal.
Tendons: Achilles tendon mildly thickened with intermediate T2 signal consistent with mild tendinopathy. No significant retrocalcaneal bursitis. Posterior tibialis and the flexor hallucis longus and flexor digitorum longus tendons are intact. Increased fluid around the peroneal tendons proximal to the retromalleolar groove. Extensor tendons are intact.
Sinus tarsi: Unremarkable.
Plantar fascia: Unremarkable.
Soft tissues: Unremarkable.
IMPRESSION: 1. Small area of marrow edema within the mid lateral talar dome with overlying mild chondral fraying. These findings may reflect a subacute versus chronic low-grade osteochondral lesion.

1. High-grade high ankle injury evident by complete tear of the anterior inferior tibiofibular ligament, with a moderate grade injury of the posterior inferior tibiofibular ligament.
   
2. Chronic lateral ankle injury notable for chronic tear of the anterior talofibular ligament. Clinical exam will be a better determinant of ankle stability.
   
3. Moderate tenosynovitis of the retromalleolar peroneal tendons.
   

I feel like I've always had lower back pain on and off ever since I experienced (what I thought was) a pulled muscle when I was around 17 while rowing. I'm 35 now, and the pain this year has been so bad at times that it would wake me up, and spread to my left buttock and leg.
I had to stop my running routine. I decided to get it checked. Turns out I have DDD and bulges/herniation at L5-S1 and L4-L5 which is tugging on a few of my nerves. The spine DR pointed out that due to bone growth on top of one of the bulges it seems that I've already experienced herniation in the past... I'm guessing 18 years ago.
I'm currently on daily Ibuprofen and doing regular PT stretches, foam rolling, and exercises. The pain is bothering me, is on and off, but I'm trying to see if PT helps. I have a toddler and another one on the way, so reducing lifting or prolonged rest is not really an option.
I have more X-rays and surgical consult scheduled, and I'm also considering steroid injections. I've been reading stories about microdiscectomy and ADR here, and I'm trying to judge if this is something for me to undertake.
Anyone experienced something similar? Any stories about the pain going away through PT and exercise alone? I don't want it to get worse and I would like to "fix" it (yes, I know it might not be that simple, but I want to find the best option for me).
Attaching a bunch of MRI and DR results.
https://preview.redd.it/9oeld5p7n91d1.png?width=1292&format=png&auto=webp&s=8a8bf68e5a4cd384a7dbf0e033b87a1a23c70295
https://preview.redd.it/lsj4n4p7n91d1.png?width=3096&format=png&auto=webp&s=36a220d0d856bd83af0b72ac299acc13847daec4
https://preview.redd.it/8xp035p7n91d1.png?width=3028&format=png&auto=webp&s=524bed01c0a00612ca1e0a4fb296ea920f30a177

Narrative MRI LUMBAR SPINE WITHOUT CONTRAST ** HISTORY **: 35 years old, worsening chronic low back pain. ** TECHNIQUE **: MR images of the lumbar spine acquired without intravenous contrast. COMPARISON: None available. ** FINDINGS **: NUMBERING: Last fully formed disc space is designated L5-S1. SPINAL CORD: Normal conus. Conus terminates at the L1 level. DISCS: Multilevel disc dessication at L4-L5 and L5-S1. BONES: Normal vertebral alignment. Normal vertebral body height. Marrow signal is normal. SOFT TISSUES: Normal. T12-L1: No canal or foraminal stenosis. L1-L2: No canal or foraminal stenosis. L2-L3: No canal or foraminal stenosis. L3-L4: No canal or foraminal stenosis. Mild facet arthropathy bilaterally. L4-L5: Left asymmetric lateral disc bulge causing mild left neural foramen stenosis. Mild facet arthropathy bilaterally. L5-S1: Left asymmetric disc protrusion effacing the left lateral recess and compressing on the left S1 nerve root. No significant central canal stenosis or neural foramen stenosis. Mild facet arthropathy bilaterally. OTHER: None. 

Narrative MRI LUMBAR SPINE WITHOUT CONTRAST ** HISTORY **: 35 years old, worsening chronic low back pain. ** TECHNIQUE **: MR images of the lumbar spine acquired without intravenous contrast. COMPARISON: None available. ** FINDINGS **: NUMBERING: Last fully formed disc space is designated L5-S1. SPINAL CORD: Normal conus. Conus terminates at the L1 level. DISCS: Multilevel disc dessication at L4-L5 and L5-S1. BONES: Normal vertebral alignment. Normal vertebral body height. Marrow signal is normal. SOFT TISSUES: Normal. T12-L1: No canal or foraminal stenosis. L1-L2: No canal or foraminal stenosis. L2-L3: No canal or foraminal stenosis. L3-L4: No canal or foraminal stenosis. Mild facet arthropathy bilaterally. L4-L5: Left asymmetric lateral disc bulge causing mild left neural foramen stenosis. Mild facet arthropathy bilaterally. L5-S1: Left asymmetric disc protrusion effacing the left lateral recess and compressing on the left S1 nerve root. No significant central canal stenosis or neural foramen stenosis. Mild facet arthropathy bilaterally. OTHER: None. 

I recently made an appointment with Gait Happens and they request videos of you walking and so I thought 5 minutes of barefoot walking wouldn’t kill me. Now I have completely irritated my sesamoid. Is this normal for a tibial Bone Marrow Edema- sesamoiditis? I’m concerned I might have a fracture or something.

Thank you, PSA

After the traumatic loss of our kitten (FIP) 2 months ago, we’ve had some medical fears for our other cat. She is a spayed DSH approx 15 months old. She is in good health and seems perfectly fine. We did blood testing to ease any fears even though there was nothing wrong and it’s done the opposite. She was feral when we got her 4 months ago. In November, she was trapped by a rescue after months of hanging around a farm at about 9 months old. I adopted her at about 12 months old. During her time at her cat sanctuary and then foster home she stayed hidden and was still quite scared. Within 2 months of adoption she became my shadow but is still skittish with changes and loud noises (and still skittish around my husband). Needless to say she is very stressed with trips to the vet but she freezes in fear instead of lashing out. She does have some gingivitis around her front teeth only. Also most likely a chronic URI (she grunts a bit at times but lungs are clear). Currently being fed T/D dry and C/D wet (no urinary issues). She is 12 lbs, vet wants to get her back down to 10 so no longer free feeding.
So far my vet has said we don’t want to go down any rabbit holes or worry too much yet but after rechecking in 3-4 months we may consider other steps (such as checking bone marrow). She said possibly stress or due to inflammation (gingivitis) so could be nothing bad. On these results you can also see her previous results from March to see the changes. Testing was done in house.
Please let me know if you require any more info.
Looking for any thoughts or insights. I’m thinking possibly send out (IDEXX) next time to see if any difference. How concerned should we be?
Thanks so much. Picture attached in comments.
Editing to add: Also tested negative for FelV

options to reduce over thinking along with keeping meals nutritious and full of protein

• Turkey sandwhich
• Steak egg and cheese sandwich
• Steak, onion, peppers, cheese
• Steak, eggs, apple, pear
• Good culture milk with banana, coconut granola, pistachios, three wishes, cashew balls
• Steak noodles
• Bone marrow rice with steak or chicken
• Honey garlic potatoes (tiky) with steak or chicken
• Seafood cakes
• Chicken and turkey cakes
• Pork belly and eggs and rice
• Chicken sausage, onions and rice
• Almond pretzel chicken

This question came up for me when I saw this one profile on Bumble while swiping. The woman said in her bio she had ALS and appeared to be in mid-to-late stage of the disease based on her photos. I don’t think a serious relationship would be realistic for me personally. Maybe seeing them casually, but nothing beyond that. That’s just what I would do.
What’s y’all’s thoughts?
I also recently listened to the episode of the Ricky Gervais Show where they had a debate about this. Though it was mostly making fun of Karl’s thought process when a date mentioned to him see had a problem with her bone marrow