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Forza Motorsport Update 8.0 Release Notes – May 13, 2024

2024.05.13 18:02 nukleabomb Forza Motorsport Update 8.0 Release Notes – May 13, 2024

Today’s update introduces new fixes and experience improvements to Forza Motorsport, including tweaks to how Safety Ratings are calculated in Featured Multiplayer, a gloss-matte slider in the Livery Editor, a new Tire Wear scale option for Free Play and Private Multiplayer, and changes to Drivatar AI braking behavior.
Update 8 is headlined by the Track Toys Tour alongside its Spotlight cars – three of which are either new or returning to Motorsport – that you can race in weekly events across Career, Multiplayer and Rivals. We’ve also added Mobil 1 track signage at Maple Valley, placed a barrier along the pit exit at Mid-Ohio Sports Car Course, and reset leaderboards for Le Mans layouts following changes made to the track in the previous update.
In addition, starting with Update 8, players with VIP Membership can look forward to an exclusive 15% discount on a car every week in the Showroom, which will now be available alongside the Spotlight cars and the month-long VIP discount car.
Below is a summary of new content and features, as well as items fixed or improved in Update 8:

Game Content, Features and Events [All Platforms]

Career Events
Reward Cars
Spotlight Cars
VIP Discount Cars

Multiplayer Events

Spec Series
Open Series
Spotlight Series
Rivals Events

Bug Fixes and Improvements

Stability [All Platforms]
PC
Gameplay [All Platforms]
Multiplayer – Matchmaking and Events [All Platforms]
Car Balancing [All Platforms]
Featured Multiplayer Spec SeriesCar NameChange Summary Forza GT Series2019 Ginetta G55 GT4Engine torque: +25% Car Mass: +13.4% Front Downforce: -45% Rear Downforce: -45% Early Factory Racecar Series1997 McLaren F1 GTIncreased Power 10% Early Factory Racecar Series1997 Porsche 911 GT1 StrassenversionIncreased Power 13% Lowered weight/ballast 3% Early Factory Racecar Series1989 Ferrari F40 CompetizioneIncreased power 10% Weight decreased 2%

Drivatar AI [All Platforms]
Tracks [All Platforms]
Cars [All Platforms]
Livery Editor [All Platforms]
Accessibility [All Platforms]
Localization [All Platforms]
submitted by nukleabomb to forza [link] [comments]


2024.05.07 19:54 Business-Constant540 Motors arent spinning

i have this PID control that i wanna use to stabilize a drone, idc about flight right now, i just want it to spin the motors at 50% speed and then add the PID output to the base speed "
#include  #include  #include  #include  Adafruit_MPU6050 mpu; ArduPID controlRoll; ArduPID controlPitch; double rollSP = 0; double pitchSP = 0; double rollInput; double pitchInput; double rollOutput; double pitchOutput; // Initially set low PID values for smoother control double rollP = 0.1; double pitchP = 0.1; double rollI = 0.0; double pitchI = 0.0; double rollD = 0.1; double pitchD = 0.1; const int esc1Pin = 17; const int esc2Pin = 5; const int esc3Pin = 18; const int esc4Pin = 19; int valanMax = 950; int valanMin = 450; void setup(void) { Serial.begin(115200); while (!Serial) { delay(10); // Wait for serial monitor to open } // Attempt communication with MPU6050 if (!mpu.begin()) { Serial.println("Failed to find MPU6050 chip"); while (1) { delay(10); } } // Initial motor spin at slightly above minimum (adjust if needed) analogWrite(esc1Pin, valanMin + 10); analogWrite(esc2Pin, valanMax - (valanMin + 10)); analogWrite(esc3Pin, valanMin + 10); analogWrite(esc4Pin, valanMax - (valanMin + 10)); mpu.setAccelerometerRange(MPU6050_RANGE_16_G); mpu.setGyroRange(MPU6050_RANGE_250_DEG); mpu.setFilterBandwidth(MPU6050_BAND_21_HZ); Serial.println(""); delay(100); pinMode(esc1Pin, OUTPUT); pinMode(esc2Pin, OUTPUT); pinMode(esc3Pin, OUTPUT); pinMode(esc4Pin, OUTPUT); controlRoll.begin(&rollInput,&rollOutput,&rollSP,rollP,rollI,rollD); controlPitch.begin(&pitchInput,&pitchOutput,&pitchSP,pitchP,pitchI,pitchD); } void loop() { // Base speed for 50% throttle with slight adjustment (optional) const double baseSpeed = valanMin + (valanMax - valanMin) * 0.5 + 10; // Read sensor data sensors_event_t a, g, temp; mpu.getEvent(&a, &g, &temp); // Calculate roll and pitch angles from accelerometer data int gradosRoll = atan2(a.acceleration.y, a.acceleration.z) * RAD_TO_DEG; int gradosPitch = atan2(-a.acceleration.x, a.acceleration.z) * RAD_TO_DEG; // Optional gyro drift compensation (adjust values as needed) g.gyro.x = g.gyro.x + 0.01; g.gyro.y = g.gyro.y + 0.085; // Set roll and pitch inputs for PID controller rollInput = gradosRoll; pitchInput = gradosPitch; // Perform PID calculations to determine motor adjustments controlRoll.compute(); controlPitch.compute(); // Calculate motor signal with base speed (adjusted for deadzone) int motorSignal = map(rollOutput + pitchOutput + baseSpeed, -valanMax, valanMax, valanMin + 10, valanMax); // Constrain motor signal within valid ESC range motorSignal = constrain(motorSignal, valanMin + 10, valanMax); // Set motor signals for each ESC with direction control analogWrite(esc1Pin, motorSignal); analogWrite(esc2Pin, valanMax - motorSignal); analogWrite(esc3Pin, motorSignal); analogWrite(esc4Pin, valanMax - motorSignal); // Uncomment for debugging (optional) Serial.print("Grados Roll:"); Serial.print(gradosRoll); Serial.print(" Grados Pitch:"); Serial.print(gradosPitch); Serial.print(" senal motor:"); Serial.println(motorSignal); delay(100); } " 
submitted by Business-Constant540 to Arduino_AI [link] [comments]


2024.05.07 19:51 Business-Constant540 PID help

im using a MPU6050 to stabilize a drone, idc the fight, i just want it to not move on roll and pitch this is the code and ill apreciate any help "
#include  #include  #include  #include  Adafruit_MPU6050 mpu; ArduPID controlRoll; ArduPID controlPitch; double rollSP = 0; double pitchSP = 0; double rollInput; double pitchInput; double rollOutput; double pitchOutput; // Initially set low PID values for smoother control double rollP = 0.1; double pitchP = 0.1; double rollI = 0.0; double pitchI = 0.0; double rollD = 0.1; double pitchD = 0.1; const int esc1Pin = 17; const int esc2Pin = 5; const int esc3Pin = 18; const int esc4Pin = 19; int valanMax = 950; int valanMin = 450; void setup(void) { Serial.begin(115200); while (!Serial) { delay(10); // Wait for serial monitor to open } // Attempt communication with MPU6050 if (!mpu.begin()) { Serial.println("Failed to find MPU6050 chip"); while (1) { delay(10); } } // Initial motor spin at slightly above minimum (adjust if needed) analogWrite(esc1Pin, valanMin + 10); analogWrite(esc2Pin, valanMax - (valanMin + 10)); analogWrite(esc3Pin, valanMin + 10); analogWrite(esc4Pin, valanMax - (valanMin + 10)); mpu.setAccelerometerRange(MPU6050_RANGE_16_G); mpu.setGyroRange(MPU6050_RANGE_250_DEG); mpu.setFilterBandwidth(MPU6050_BAND_21_HZ); Serial.println(""); delay(100); pinMode(esc1Pin, OUTPUT); pinMode(esc2Pin, OUTPUT); pinMode(esc3Pin, OUTPUT); pinMode(esc4Pin, OUTPUT); controlRoll.begin(&rollInput,&rollOutput,&rollSP,rollP,rollI,rollD); controlPitch.begin(&pitchInput,&pitchOutput,&pitchSP,pitchP,pitchI,pitchD); } void loop() { // Base speed for 50% throttle with slight adjustment (optional) const double baseSpeed = valanMin + (valanMax - valanMin) * 0.5 + 10; // Read sensor data sensors_event_t a, g, temp; mpu.getEvent(&a, &g, &temp); // Calculate roll and pitch angles from accelerometer data int gradosRoll = atan2(a.acceleration.y, a.acceleration.z) * RAD_TO_DEG; int gradosPitch = atan2(-a.acceleration.x, a.acceleration.z) * RAD_TO_DEG; // Optional gyro drift compensation (adjust values as needed) g.gyro.x = g.gyro.x + 0.01; g.gyro.y = g.gyro.y + 0.085; // Set roll and pitch inputs for PID controller rollInput = gradosRoll; pitchInput = gradosPitch; // Perform PID calculations to determine motor adjustments controlRoll.compute(); controlPitch.compute(); // Calculate motor signal with base speed (adjusted for deadzone) int motorSignal = map(rollOutput + pitchOutput + baseSpeed, -valanMax, valanMax, valanMin + 10, valanMax); // Constrain motor signal within valid ESC range motorSignal = constrain(motorSignal, valanMin + 10, valanMax); // Set motor signals for each ESC with direction control analogWrite(esc1Pin, motorSignal); analogWrite(esc2Pin, valanMax - motorSignal); analogWrite(esc3Pin, motorSignal); analogWrite(esc4Pin, valanMax - motorSignal); // Uncomment for debugging (optional) Serial.print("Grados Roll:"); Serial.print(gradosRoll); Serial.print(" Grados Pitch:"); Serial.print(gradosPitch); Serial.print(" senal motor:"); Serial.println(motorSignal); delay(100); } " 
submitted by Business-Constant540 to diydrones [link] [comments]


2024.05.07 13:10 PalacsintaKiralyno My semis prediction spreadsheet + explainer (vs. what shock NQs/Qs I think might happen)

My semis prediction spreadsheet + explainer (vs. what shock NQs/Qs I think might happen)
Hi!! Sorry mods, hopefully I am posting this correctly this time around! Apologies also for the length and small size of the text.
Tl;dr: I spent about 2 hours making a spreadsheet of my semis predictions (below). Methodology explained underneath, opinions at the end. If you are a maths person, please chime in! I did my best to avoid giving overly low/high scores to too many acts. You could say that most are "In The Middle" :)
Below will be the table itself, then the breakdown of what everything means, and how I scored/calculated it. All scores are done out of 10! At the end, I have my personal opinions (that do not match my 'calculations') and some other thoughts/questions.
But first, a question: Who are your predicted shock qualifier and non-qualifier?
For me, I would say maybe Finland NQ and Poland Q (although my 'calculations' say Poland is safe, I am not so sure; and I could maybe see Windows95Man scandalising people with his booty out). For SF2: shock Q as Malta (please! I am begging! The voice, the choreo!), and shock NQ as Norway (I would be absolutely heartbroken to lose them! But maybe rock voters split between them and San Marino...)
Disclaimer: I do not have a professional or academic background in statistics. I hope it all makes sense in the breakdown section. Please correct me if anything is strange/wrong. And, most of the scores are not free from bias, as much as I tried to mitigate that.
Sorry if the quality is not great. Funnily enough, I got very similar results to the actual, current odds. Yet neither match my own opinions/wishes!
Before I explain everything: please note that the Big Five + Sweden odds used are from their chances of making the Top 10. I felt that was more fair than just using their odds to win. I skipped running order for them, as we do not know how RO might impact their results yet. So, a large margin of error for those 6 countries (even more than for the rest, lol!)
This is far from a perfect science! Just the result of a sleepless night and a very excited/anxious ESC brain. Anyway, here's the methodology and terminology:
Categories from left to right: 1. First impressions (my own) 2. First impressions (guesstimating based off comments off YouTube, family/friend reactions, etc.) 3. Vocals = self-explanatory. Not objective though. (Live vocals) 4. Staging = ^ 5. Memorability = how likely is a first-time listeneviewer to remember this song by the time voting starts? 6. Running order = how much does the slot benefit/harm them, and how much does the act stand out from the songs immediately before and after? 7. Public vote = kind of ties into Memorability + RO + performance. But also tried to weight who is most likely to 'convince' someone to vote for them. 8. Odds = the current qualification odds, but as a proportion out of 10 (since all other scores are out of 10)
(The darker blue columns are the average of the two columns immediately to the left.) 1. First impression (mine + "public" estimate) 2. Performance (vocals + staging) 3. Overall memorability 4. Combo of guessing how the votes will go + current odds
Then, I weighted each of the four averages and added them together, then divided by 10 to keep everything in the same range as all the other numbers.
The formula I settled on to get the 'total' score was:
1.5 x (First Impressions) + 2.5 x (Performance) + 3.5 x (Memorability) + 2.5 x (Combo Prediction + Odds) And then divide by 10.
It is not an exact science, already half of it is my own bias. I did my best to listen/watch the rehearsal clips as objectively as I could for those scores. I tried to guess if anything was 'too risqué' or 'too avant garde' (etc.), anything that would 'put off' an 'average' first-time watcher. Once I plugged everything into the formula above, I further weighted everything by factoring in *potential* bloc voting (e.g. friendly neighbour countries, shared cultures, or large diasporas in the same SF, historical closeness, etc.). Anything red/orange is in NQ for that whole column, and any country 'at risk' is italicised on the right-hand side, to make it easier to see!
Other info: I made the 'cut-off' for certain predictions 6.5 in the unweighted scores (totally arbitrary, I know). So that's why there are not 10 acts for the 'certain qualifiers' in either semi. And obviously, the performance scores are just based off the official rehearsal clips. So the actual performances could be better or worse! (Hopefully all even better!)
Do you have any recommendations on how I could do this more objectively? E.g. surveys that do not include just us hardcore fandom members? Would creating a scale for streaming numbers or YouTube views work?
Personal opinions / What I think will *actually* happen:
Please note, my first impression scores do not reflect my current opinions of songs!! So many have grown on me, and I genuinely love about 30 out of the 37 songs this year -- the most ever for me in an ESC. These 'first impression' rankings all come from a list I made, updating only once a country confirmed an entry and I listened to it for the first time. If I could, I would give so many songs a 10, but I know that in reality, that is not how it works lol
***Personally, what I wish to happen does not match my own predictions. I would LOVE to see Serbia and Slovenia qualify today. And for SF2, I would really love for Malta, Czechia, and Belgium to qualify. Tbh, I would like everybody to qualify this year!
Last note regarding predictions: I am personally not 100% certain on Portugal, Finland, Poland, and Cyprus qualifying -- but my "data" does not match that. It is a gut feeling, I cannot really explain why. I could see them being too much or too little for a first-time viewer. Definitely not 'safe' qualifiers in my opinion. For SF2: Norway, Georgia, Austria, Estonia. Same reasons. I'm scared we could be way overestimating how well-liked some songs may be, especially for the pop/dance break ladies, ballads, and the fun entries like Estonia and Finland.
There are so many factors we cannot predict! I always remember how certain I was that Citi Zeni would qualify in 2022 for Latvia, and then they turned out to be dead last in their semi :( Or the shock at Uku Suviste going through in 2021 for Estonia! And I'm still not over Brooke Scullion (Ireland 2022) and Albina (Croatia 2021) NQ-ing... I thought they were that pop girly!
If you read all this, I hope your favourite qualifies today! Sending everybody a lot of love for tonight!!!!
submitted by PalacsintaKiralyno to eurovision [link] [comments]


2024.05.06 18:38 lsorman Casio force everywhere ✨

Casio force everywhere ✨
There's not a force in space to break this Power!
submitted by lsorman to casio [link] [comments]


2024.05.06 09:23 Training_Sky8546 Article: What does the ESC cost the participating countries? (with answers!)

TL;DR
• EBU provides hosting country with a base amount of around 6.2 million euros
• The 6.2 euros are financed proportionally by the participating countries (participation fee)
• The broadcaster of the host country has to pay additional 10-20 millions from its own pocket (made possible through sponsorship)
Longer Version translated by AI
(…) But is participating in the ESC really that expensive?
A significant part of the total costs for participating countries is the fee they must pay to the European Broadcasting Union (EBU) to participate in the competition at all. Compared to other TV broadcasts, this fee is relatively low, but it has steadily increased in recent years (…)
Shortly before that, Swedish television SVT announced that the participation fee would increase, without providing precise information on the future amount. This is said to be due, among other things, to Russia's non-participation, but its cause is probably primarily due to generally increased production costs.
ESC fees for individual participating countries:
Although sums for some countries can be found in the media, many broadcasters refrain from publishing them.
Country + Fees to the EBU / partially rounded
Germany (2015) 363,500 euros
Germany (2017) 380,000 euros
Germany (2018) 400,800 euros
Germany (2019) 405,100 euros
Germany (2021) 396,452 euros
Germany (2022) 407,000 euros
Germany (2023) 473,000 euros
Greece (2012) 120,000 euros
Greece (2023) 150,000 euros
Ireland (2013) 70,000 euros
Malta (2010) 80,000 euros
Montenegro (2012) 23,000 euros
Netherlands (2016) 250,000 euros
North Macedonia (2022) 39,143 euros
Romania (2014) 130,000 euros
Switzerland (2016) 63,500 euros
Spain (2015) 356,000 euros
Spain (2022) 640,000 euros
Spain (2023) 347,700 euros
The fact that the participation fees vary so widely has something to do with the EBU's redistribution system: Each full member of the broadcasting union is assigned a point value based on its reach and the usage of Eurovision offerings (including news footage and sports broadcasts). Based on these point values, the total costs for joint productions are distributed among the individual participating states. In financing the ESC, the EBU provides the hosting country with a base amount of around 6.2 million euros, as reported by the newspaper "Daily Star." These funds are then financed by the countries broadcasting the ESC as a participation fee proportionally through redistribution. The hosting broadcasting organization must then contribute between 10 and 20 million euros from its own pocket, which is also made possible through sponsorship.
(…)
Are the Big Five really the paymasters of the ESC?
Despite claims that the Big Five countries (Germany, UK, Spain, Italy, and France) finance the lion's share of the ESC production costs, the actual numbers suggest otherwise. While they contribute the highest participation fees, they're not necessarily the main financiers of the competition. For instance, Germany's contribution to the total cost of around 11 million euros for the ESC in Turin was only 3.7 percent, as countries contribute only through their fee redistribution. Similarly, Spain's share of the total costs of around 15 million euros for the ESC in Vienna was just 2.4 percent. Being the paymaster seems somewhat different. The overall balance is similar for the other Big Five countries, but the complaints about fee waste are louder in countries with lackluster performance.
Total costs versus benefits
In fact, the Eurovision Song Contest is a comparatively inexpensive TV format for the hosting broadcasters. British economist Stephen Boyle calculated in 2016 that the 14.3 million euros (note: not officially confirmed by SVT) estimated by Swedish TV as the pure production costs for all three shows in Stockholm, for example, correspond to the costs of broadcasting rights for a Premier League football match. In return for the ESC, broadcasters get TV entertainment that they could hardly produce at this level themselves.
A similar calculation was made in 2015 on eurovision-spain.com regarding the costs of the Spanish broadcaster TVE: According to this, the price for one minute of ESC broadcast was 791 euros, while one minute of a 2016 UEFA European Championship football match (with a similar expected viewership) cost 21,600 euros. It begs the question: If it didn't pay off, wouldn't they have stopped it long ago?
ESC pays off for ARD - and the hosts
The ESC entry fees for Germany in 2023 are significantly below the average production costs of prime-time entertainment shows. The value in return is high, consisting of broadcasting the ESC final and the two semi-finals - a total of around eight hours of television.
Host cities like Turin or this year's Liverpool emphasize the importance of the Eurovision Song Contest for the local economy and society. The EBU itself has produced a report on the sustainable impact of the competition in 2022, which might be worth reading before calling for the next withdrawal from the contest.
source - in German
submitted by Training_Sky8546 to eurovision [link] [comments]


2024.05.06 01:42 medicoservices Help my calculator isn’t charging and i have my finals tomorrow

I have tried various charging bricks and it always stays at „critical battery“ work any help??
submitted by medicoservices to calculators [link] [comments]


2024.05.05 15:46 Pulec Understanding eCalc -Motors at Maximum vs Optimum Efficiency, 4s 3" build 1404 4000kv or smaller/bigger motors?

I am doing my #2 build and calculating everything through eCalc multicopter, first build is ~300g take off 4" LR with 1404 3000kv, 3s or 4s, flies slow but decent. I don't have much experience, but in terms of max speed and flight time the calculations are pretty accurate.
Second build is 3" with 140mm wheelbase at 45g, 35A esc ~10g, planning 4s LiPos at around 850mAh and props 3" at 1.5" pitch with 3 blades.
With these values I get best results with Diatone Mamba Toka 1404 4000Kv, largest mixed flight time and hover time. Thrust-Weight and Specific thrust is at nice numbers.
There is also Toka 1404 5000kv and the difference between 4000kv is mainly in higher payload, higher weight to ratio and higher power used.
The part that gets me is the RPM Maximum for motor vs Optimum Efficiency stats.
For 4000kv it's 47156rpm maximum at 82% efficiency and 47455rpm optimum at 81.9% efficiency, so just 299rpm off, at full throttle.
For 5000kv it's 51904 maximum at 80.1% efficiency and 59308 optimum at 81.9% efficiency, so 7404rpm off to optimum.
At 51904 rpm the 3" prop tip would spin at crazy 463mph anyway according to WarpDriveProps calc, so 4000kv and staying around 40000rpm makes more sense.
The hover speed is 22045 rpm for both motors, but efficiency is 72.4% for 4000kv and 66.4% for 5000kv and based on the graph the efficiency is nice on most throttle levels.
I have tried calculating with number of motors (ideally those that are in stock and in eCalc db) and 1204 4000+kv motors or 1604 3xxxkv or 1804 and the specs weren't looking better.
With smaller motors its often at the limit of the 4s and risk of overheating/burning.
With bigger motors it's lower Thrust-Weight ratio, perhaps less power used in bigger motors, but the the maximum rpm speed is almost always few k rpm higher than optimum, 38k rpm at max compared to 30k optimum for example. In that case it would be pointless to do more than e.g 75% throttle.
As I am seeing lots of 3" build with 1604 or 1804 and seeing these calculations I am confused about what would be the performance/flyability of different setups.
I am not sure what features I am looking for, it shouldn't be a racer nor camera lifter nor freestyler ready to get banged up.
I guess long range would be closest since I would like to have nice efficiency at 30-40% throttle just bit about hover, but of course with 850mah it would be 5 minutes flight max anyway, some very big LiPos or LiIions.
All in all I just enjoy doing the numbers and calculate everything possible and then making it a reality and see what was off.
submitted by Pulec to fpv [link] [comments]


2024.05.05 12:28 Suburbforest Making a traditional Finnish "Sima" with honey

Making a traditional Finnish
https://preview.redd.it/34078j035lyc1.jpg?width=2048&format=pjpg&auto=webp&s=fc01634c9587a844fcccc3d1bc2c821f3c935e12
I saw this chart on this subreddit, and to my big surprise it contained "sima", which is a May Day celebration drink in Finland. The reason I was surprised is because it is actually never made with honey, although it has historical roots in mead. I guess this is the logic of whomever made the chart. From the scarce information I can find about the subject on the internet, scholars seem to draw a link with actual mead and the current sima beverage. I could not find an explanation exactly how old or common this term is, and was it actually used before the 19th century. The drink itself is pretty simple: Sugar and water are mixed and fresh lemon is added along with a pea sized bread yeast. Let ferment for a day, transfer to cold for a few days and enjoy (recipe follows). The drink is very refreshing and sweet, and the lemon with the cane syrupy and yeast aromas create a unique taste experience.
We do know that the drink was mainly conceived during the latter half of the 19th century. This was due to the industrial revolution, as beet sugar farming and factories were introduced in the nordics; hence the much lower sugar prices which made it more accessible to lower income households. Other claim I've ran into is the point that it was highly pushed forward as a celebratory drink by the temperance movement, due to it's very low alcohol content. The drink has survived to this day, but is traditionally only made and enjoyed during the may day celebrations. Also, people prefer the home made one, but there are many commercial brands available in regular stores before and during the festive period. The commercial bottles still read Sima (finnish) and Mjöd (swedish), as Finland is officially a two language state. Now, everyone probably knows that mjöd means mead. So there's the conundrum. It seems that the wealthy households in Finland made their own meads prior to the 19th century, and there is a cookbook from 1755 by Cajsa Warg (page 628->) which they apparently used extensively. My quick calculations gave a reading of about 9% ABV if the yeast would devour all the sugars in the honey. The recipe ends up spicing the brew in secondary with cinnamon and fresh lemons. So sounds a bit similar. The oldest mead recipe from finland was a second hand depiction from 1589 by Johann David Wunderer from his travels to the nordics. He claims that the recipe is how they make mead in the Turku (finnish) or Åbo (swedish) castle.
https://preview.redd.it/z25cw3885lyc1.jpg?width=2048&format=pjpg&auto=webp&s=72b435842d40a0226e4c83b68be2214afa17b828
Anyways, here's my take on the traditional may day sima, which turned out deliciously fragrant and delicate, compared to the all-sugar original. All thanks to the wild flower honey I used:

Honey Sima

  • Water to 8 liters
  • 500 grams of honey
  • 500 grams of farine sugar (granulated beet sugar, that has cane molasses syrup. Substitute with brown sugar if not available)
  • 3 fresh lemons
  • 1 tsp of yeast
  1. Pour in weighed sugar and honey
  2. Mix until dissolved. You can add half of the water boiling, so you'll have a warmer wort, depending on what kind of yeast you use. Bread yeast wants it body temp, and I used wet kveik yeast that wants a high temp as well. So everything depends on your yeast.
  3. Wash an peel lemons with a peeler. Cut out the white zest out and slice the lemons.
  4. Add lemons, peels and yeast to the bucket.
  5. Let ferment in a temp that's suitable for your yeast for 24-48 hours.
  6. Add sulfites/sorbates (optional)
  7. Rack to soda (PET) bottles
  8. Carbonate. You can do this in several ways. One way is to close up the bottles tight and leave in a warm bathroom for a few days until the bottles are rock hard, this way it's easier to clean if some of them might explode. This means the carbonation is working. Release some pressure and you can transfer them to a fridge to cool down to serving temp.. Another way is to put them in a fridge immediately and let them stay there for a longer time. The carbonation might take longer and be more petillant rather than sparkling. If you're unsure if the bottles have too much pressure, you can always release the gas every now and then. Personally, I like to carbonate with straight Co2 from a soda stream container. Straight to the bottle and shake.
  9. Serve cold with sugary donuts.

Traditional Sima

  • Water to 8 liters
  • 500 grams of white sugar
  • 500 grams of farine sugar
  • 2 fresh lemons
  • raisins
  • 1 chick pea sized ball of bread yeast
The traditional recipe follows the aforementioned one pretty much the same way, but usually the lemons are just sliced without peeling, and the primary fermentation is just 24 hours. You also add a few raising to the bottles prior to bottling. People believe that "the sima will be ready when the raisins rise to the top" which is just pretty much silly.
Enjoy guys!
https://preview.redd.it/bu6oj7f65lyc1.jpg?width=2048&format=pjpg&auto=webp&s=e3a4ca062bd054c1ed7d1d03ef20ee3744224e65
submitted by Suburbforest to mead [link] [comments]


2024.05.05 04:58 Gbutcher2005 I am curious about my plans for a freshman year

I am curious about my plans for a freshman year
Here are the classes I’m taking. I am majoring in finance. What are your thoughts on the schedule.
submitted by Gbutcher2005 to UTSA [link] [comments]


2024.05.04 20:57 Charming_Radio_5798 Am i the only one with this problem ? i tried on many devices that even think termux has shut down or something

submitted by Charming_Radio_5798 to termux [link] [comments]


2024.05.04 20:02 Fatshark_Flipper Calculating thrust for motors.

Right now i'm using https://rcplanes.online/calc_thrust.htm to calculate the thrust my motors will output [testing different motoprop combinations for new build]. I need to use the the supply voltage and current features, but I'm not exactly sure how to use it. I'm using a 4in1 Esc rated for 50a, so i believe, for one motor, it would supply 12.5 amps. I'm running 4-cell voltage so I just plugged in 14.8 volts. Does this calculator assume this is the input voltage and current to the motor or the ESC inputs? If it's the motor, than is the motor input voltage the same as the esc input voltage? [Yes, i know the RPM is stupidly high. I know it's not realistic. All i need to know is the voltage and amps to make sure i get motor output power right.]
submitted by Fatshark_Flipper to RCPlanes [link] [comments]


2024.05.03 04:08 mrgoose47 Where high school algebra word problem?

Where high school algebra word problem? submitted by mrgoose47 to AFCSouthMemeWar [link] [comments]


2024.05.01 21:39 ted_144 My Quad motor car is almost complete

My Quad motor car is almost complete
4x 2205 motors 250W on each wheel, front and rear steering, 100mm suspension travel and 45° caster angle.
The battery and the ESCs are inside the chassis. Calculations for motors speed will be done on Arduino MC.
submitted by ted_144 to EngineeringNS [link] [comments]


2024.05.01 17:54 MadChatter715 4268 2600kv + 3S 6500mah 150C + 3S ESC = BOOM

Learned something yesterday, don't use a 1/8th motor with a 1/10th ESC. I paired a Hobbywing QuicRun 4268 2600kv to my VXL-3S with a 3S 150C battery because I wanted more torque. It crawled around just fine, but as soon as I pulled the trigger, it went up in flames. I'm guessing the motor and battery drew way more amps than the ESC could handle. I thought I'd be fine since I was only running on 3S and both the motor and ESC were using 6.5mm bullet connectors, but the ESC is not smart enough to govern how many amps it can take. The VXL-3S can take 320 peak amps, amps = watt/volts, I wish manufacturers printed out how many watts their motors make so we could calculate the amps draw.
submitted by MadChatter715 to rccars [link] [comments]


2024.05.01 02:58 Ok-Lingonberry-137 Mk armor Magegee

Hello, I would like to see if someone has looked for the solution or if I really have to buy a new keyboard. It turns out that when I was playing, my keyboard started writing the W with the 8 type like this (w8) and also the (a5) for the letter A. In addition to that, the Windows key literally opens the calculator and does not open the Windows window, it is quite annoying when trying to exit the screen, I had seen that pressing Fn+Esc then F1, F3, F5 returned the keyboard to factory settings but this is only a temporary solution, just like when you are in the Google search engine, when you press W, paste one of the searches as it is, if someone can help me I would be grateful
submitted by Ok-Lingonberry-137 to keyboards [link] [comments]


2024.04.30 08:45 -Lambert- My long feedback and wishlist after 30 hours of early access

I'm going to post a lot of critique here so let me start by saying I enjoyed the game a lot, in fact I didn't play video games for a long time due to depression and being able to sunk in 30 hours in just a few days was definietly suprising to me. Generally I would say the game released too soon for early access, and is a bit pricey compared to other titles when it comes to content but I hope with extra funds slavic magic will be able to assemble bigger team and overhauls the game a little to make this project truly special, I would gladly pay for this game again if that happens.
Hopefully Greg sees this and considers some points for future roadmap :)
And here comes the long list of my wishes, bugs, praise, thoughts etc in no particular order. I'll edit the list once something new comes to my mind:
submitted by -Lambert- to ManorLords [link] [comments]


2024.04.29 18:39 Neither-Ad-9012 Help! - No Calc Shortcuts on Medify

[REDUNDANT] Medify have already updated the practice Qs (however not the QR Skill Trainer) on their site to use these shortcuts:
Alt+C - Open/Clear Calculator (Clears in the same way as backspace would, given that it's already open ofc)
Esc - Close Calculator
C - Shortcut to MCR (single input to Recall, but 2nd input to Clear Memory)
P - Shortcut to M- (subtract the current value displayed from value stored within memory)
M - Shortcut to M+ (add the current value displayed to value stored within memory)
(No Shortcut, but no big deal) X - Shortcut to √ (square root the current value displayed)
submitted by Neither-Ad-9012 to UCAT [link] [comments]


2024.04.28 12:51 ColeWalkeroftheRim Press Y? Abort

Hey there! Im following the instructions to download SillyTavern on android, and the prompt says to press Y/n. I press Y and nothing happens. If I press enter after, it just says Abort. and nothing happens. Did I botch something already? Im new to all this.
submitted by ColeWalkeroftheRim to termux [link] [comments]


2024.04.26 15:01 Dmax_05 Flight Time Calculation

Hello, I don't know if this is the right place to ask this kind of questions but I'll try anyway. I want to build a drone with the following specs but I don't know how to calculate it's flight time.
Weight: 1616gr
Fixed Wing Single Motor
Motor: 1100KV, 2150g of MAX Pull, 911W of Max Power
ESC: 70A
Battery: 6500mAh 14.4v
Other electronics total current draw: 600mAh (5V)
I am a newbie so if I forgot to post anything that might be useful feel free to ask.
Thank you in advance
EDIT: u/icebalm calculated the estimated flight time: 6 minutes. The question is: is it a reasonable flight time for an UAV of this dimensions?
submitted by Dmax_05 to fpv [link] [comments]


2024.04.25 11:35 Bayou_Bussy_Pounder I actually tested the low SOC cold weather acceleration and Volvo did too, results were just bad, really bad

Ok, I've posted many times but now I have my own data backed up by Volvo techinian who did his own tests. I mean Volvo confirmed that this is a feature.
I talked to my dealer last week and explained that the car is extremely slow if it has lower charge in colder weather but they said that they are pretty sure it's a feature. So they had a talk with a Volvo techician who did his own tests which match my tests.
The cold weather performance is hilariously bad, like you wouldn't believe how bad it is. It is so bad that people who have problems with it should definitely ask for a partial refund. Remember when I said that in below 10C weather the car loses half of the power if it's cold? Well it's actually 65% or more.
So, the tests we did:
45% charge, (very very slight uphill in the beginning) 0-100 time 9 sec
30% charge, (slight downhill for about half the distance), 0-100 time 8,4sec
We also did some 50-100 tests and 0-50 tests that showed that 0-50 is a bit better than 50-100
We are gonna do 70% and 60% test next weekend, but with me just driving the car with those charges, it feels like cold takes away at least 30% at higher charges too.
If this is actually how it performs, then it's a total joke and can even be dangerous. I would understand 20% decrease or maybe even 30% decrease, hell I would take a 50% decrease at this point, but without performance mode a 70% decrease in not even sub zero temperatures with almost half a charge is a bit much.
And this is on top of the car having absolutely horrible performance even when the battery is warmed up.
I talked to a EX40 owner who said that with 40% charge, in -22C weather, the car still gets at least half the power if you start it up cold.
To those saying to keep it charged or heat it up. How do you think I came upon these results? I have lot of situations where I have to drive it cold. Also this is soooooooo far from how even other Volvo's perform, that it's just unacceptable. This is some China tier shit.
Edit: Edited some sentences that were said multiple times.
submitted by Bayou_Bussy_Pounder to ex30 [link] [comments]


2024.04.24 11:18 Rahkrahk Cereno has presented results that look better than Sotatercept/Winrevair in PAH and are also going after thrombosis with first candidates that do not cause bleeding

This is my DD of Cereno Scientific.
Disclosure: I own the stock and this is not financial advice but a best effort to provide information and share some own current views as a start for individuals capable of doing their own due diligence. As well as hopefully discuss the case.
TLDR: This is the story of an under the radar Swedish biotech company led by ex big pharma heavy-hitters, partnered with big pharma as well as officially supported by top global key opinion leaders (KOL) within cardiovascular disease (CVD) that has patented an already is a safe, tolerable and established therapeutic since it has been shown to be efficacious against thrombosis, the #1 killer in the world. Furthermore, the company ALSO looks set to outperform established pulmonary arterial hypertension (PAH) drugs, even the new Sotatercept/Winrevair, which has an estimated $2-9B peak annual sales. Wait until you see the results, including already reported interim data on the majority of the patients in the soon to be completed phase II study.
The serendipitous mistake The founder of Cereno Scientific is Sverker Jern, a renowned Swedish cardiologist with books published about ECG, etc. Long story short, while trying to find out a way to restore the human bodies inherent blood clot preventing system, a "failed" experiment of a postdoc belonging to Jern´s lab led to the discovery that valproic acid (VPA) significantly inhibits HDAC. In turn, this significantly reduces PAI-1 while simultaneously increasing endogenous levels of tPA; both central to combating thrombosis. VPA has been around and used for treating epilepsy, bipolar disease, migraine etc. since the 1960's. While high enough dosages (typically much higher than used here) can come with adverse effects, VPA is established as a safe and tolerable therapeutic still prescribed today. Having developed a unique administration regime for VPA trough delayed-release to reduce PAI-1, which is elevated in the morning, Cereno created it´s first medical candidate, CS1. Since then, it has been shown to be safe and tolerable, reduces the levels of circulating PAI-1 as well as restore the levels of t-Pa in a phase I human trial, without increasing the risk of bleeding. Now, for those not familiar with the hematologic landscape, this is huge. The reason being that ALL existing therapeutics for thrombosis are double-edged swords that do increase this risk, causing considerable consequences for quality of life, not to mention fatal incidents. Coupled with thrombosis as the #1 underlying cause of death globally, it is not for nothing that a potential solution to this has been called the holy grail of medicine.
Global KOL's join Having made the discovery, patented it and demonstrated results in human, the company soon garnered the attention of a number of KOL´s. A scientific advisory board (SAB) was established comprised of leading global experts within CVD. Names such as Deepak Bhatt, Raymond Benza, Bertram Pitt, Faiez Zannad, Gordon Williams and Gunnar Olsson. Do look them all up. On the march towards a subsequent phase II trial for CS1, the course was initially set to directly target the medical indication thrombosis. However, following advice from the SAB, a strategical move to proving an even broader efficacy, shorten the time to market, thus preserving capital and prolonging IP rights, was chosen instead - for now - PAH.
The genius rationale behind proving broader efficacy quicker through PAH Although PAH is classified as a rare disease, the market is extensive and growing rapidly. The pathophysiology is simplified as this: Due to various etiologic backgrounds, a few being genetic, related to vascular fibrosis, inflammation, etc. the pulmonary arteries undergo constant proliferation. As they progressively become narrower, stiffer and less flexible, the pulmonary pressure is raised causing the right-hand side of the heart to also proliferate in order to pump enough oxygenated blood until there is simply no more room at which point the heart fails and the patient dies. Up until a few weeks ago (we will return to this), only simple vasodilators such as PDE5i´s which only temporarily alleviate symptoms, have been prescribed. Now, on top of the anti-thrombotic properties, it has also been established that CS1 has anti-fibrotic, anti-inflammatory, pulmonary pressure-relieving properties as well as reverse-remodeling of underlying pathological vascular changes. As the CEO of Cereno Sten Sörensen states - "CS1 fits like a hand in a glove for PAH". As a parenthesis, Sörensen successfully led the RALES study at Monsanto as well as MERIT-HF at AstraZeneca. Both aimed at expanding the use for already existing compounds, just like with CS1. As an incentive to formulate treatments for rare diseases, the FDA/EMA can grant Orphan Drug Designation (ODD). The benefits, if approved, are multifold but what is of most importance here are simplified regulatory pathways to get to market. For instance, 7 years market exclusivity is also granted but the company already has extensive patents in place. Cereno was granted ODD by the FDA in 2020. If this is deemed as a tactical sound move, the next part ought to be considered a strategical masterclass. First a bit of necessary background to make it understandable: Phase I is to evaluate safety and tolerability. Phase II trials expand on this with a larger patient sample size, as well as incorporate one or a few efficacy markers. The phase II study of Cereno is setup to measure approximately 30 of them. Why? For the sake of keeping this short, CS1 ("optimized" VPA) is an HDACi and it's mode of action is through epigenetic modulation. VPA has already in numerous studies throughout the years been found to positively impact risk markers for several CVD's and research revolving around HDACi's in general has picked up tremendous speed also in areas such as cancer treatment. It is effectively a form of gene therapy. While Cereno has specifically patented VPA, the company has additionally managed to patent ALL forms of HDACi, not only for thrombosis but also for improving endogenous fibrinolysis which could possibly be relevant for all forms of CVD but certainly for several broad indications such as heart failure, myocardial infarction and atherosclerosis. Hence, this phase II study is officially targeting PAH through markers such as mean pulmonary arterial pressure (mPAP) and 6 minute walking distance (6MWD) since everything points to that this should be a fast-forwarded slam dunk - but also incorporates markers relevant for other major indications - including PAI-1 for thrombosis. So, what started off as a mission to prove efficacy for "only" thrombosis has turned into a phase II study that will shine light on an avenue a lot broader, all at once.
In order to demonstrate this, the study participants are evenly distributed across three groups and administered one of three doses:
  1. A low dose, the same dose that reduced PAI-1 and showed anti-thrombotic properties, to confirm what was shown in Ph1.
  2. The dose shown in animal models to be clinically relevant for PAH by alleviating hypertension and show reverse remodeling capacity.
  3. Double the second dose to see whether an even higher dose means more effect and also to possibly show a dose response pattern.
I.e. a "perfect score" would be to demonstrate effects in 33% to 66% of the total number of patients depending on if dose #2 or #3 is enough in human. Regarding safety and tolerability, even the highest dose is lower than what is typically used for treating epilepsy. Furthermore, since PAH is a deadly disease with a very poor prognosis that lacks the possibility of significant spontaneous remission (patients do not get better without intervention, instead tend to progressively get worse), placebo is only formally to be included in the subsequent phase III trial and deemed unnecessary by the FDA in the ongoing Ph2 trial due to the known safety profile of VPA.
Big pharma Abbott partners with Cereno While planning for the phase II trial, Cereno and Abbott announced a mutual partnership for the same to which Abbott is to supply their CardioMEMS HF implanted sensor to Cereno's patients. The implications being multifold but mainly that instead of being bound to a few select measurements through right heart catheterization (RHC), the study now monitors many of the markers in real time. Measuring mPAP with CardioMEMS is highly superior to RHC due to the numerous measurements taken daily in comparison to RHC that is otherwise done only 3-4 times during a full trial. Due to the individual variability in the patients, RHC would demand 4 times as many patients to be able to detect the same difference in mPAP as with CardioMEMS. Further solidifying CardioMEMS as an improved health monitor by choosing Cereno and their extensive study protocol as a partner benefits Abbott.
The patents stand their ground - and Cereno scoops up two additional candidates In 2018, University of Michigan (UoM) filed for a patent for the usage of VPA to treat and/or prevent heart disease. This claim was rejected due to one (WO201605579) of the multiple patent families in place by Cereno. What then took place is beautiful:

  1. UoM licenses their own medical candidate ML585, renamed to CS585 to Cereno. A prostacyclin (IP) receptor agonist.
  2. Cereno is contacted by Emeriti Bio, (comprised of a group of legends behind multiple blockbusters such as Losec), and acquires CS014, a next generation VPA analogue. Data points to an even better safety profile than CS1, giving Cereno a potential next, next (2x) generation compound.
  3. Michael Holinstat at UoM, and the inventor of CS585, has later been engaged as the Director of translational research at Cereno to evaluate these assets through the preclinical stages of development. And both have shown to prevent thrombosis without the risk of bleeding in all research so far. In other words, Cereno is now in possession of what seems to be the only compounds in the world capable of addressing thrombosis without increasing the risk of bleeding. Seemingly three times the holy grail. Data confirming this has since been shown at the worlds most prestigious CVD conferences (ESC, ASH, ACC, BIO-EUROPE, PVRI, NAHC, CVCT, NLSDays, ISTH, EHA, etc.). Patents are already granted for all candidates.
“Remarkable!” results Since Cereno has already demonstrated efficacy for thrombosis (PAI-1), this metric should be a given success yet again and are measured once the study nears completion. But let's dive into the ones related to PAH since these are continually measured by the CardioMEMS device: During summer of -23, Cereno was contacted by one of the clinics involved, inquiring Cereno to pursue an abstract at the upcoming American Heart Association congress that was being held November -23. The first patient to complete the trial was done and had what seemed like an astounding improvement in symptoms. Cereno instead opted to communicate the results seen so far to the market. The results from the first patient? 30% reduction in mPAP. 20% improvement in Cardiac Output (CO). Improvement in WHO Functional Class (FC) from II to I, meaning from having debilitating symptoms to basically being able to live a normal life. Judging from the most prominent PAH trials, patients starting from FC III usually yield greater results than the ones starting from II. Meaning that data points to potentially even more efficacy to be tapped than for this patient. Or, as Raymond Benza, knighted director of pulmonary hypertension at Mt. Sinai Hospital in New York and principle investigator of the study and member of Cereno's SAB stated: "We were hoping for a 10% reduction (in mPAP) - here we saw a 30% reduction - That is really remarkable!"
Competitor analysis To keep this short, the only relevant reference to compare CS1 to is Sotatercept (now Winrevair). Approved by the FDA March 26th, it does come with risks of treatment adverse events such as increased risk of bleeding, hypertension, erythrocytosis, etc. but is still a significant step forward for patients suffering from PAH. Central to evaluating efficacy in PAH is PVR and 6MWD. PVR is calculated (PVR=80(mPAP-mPAWP/CO)) once the study is completed. So far there is both mPAP and CO from the first patient. 6MWD is also communicated at study completion. But already in the first patient, Cereno demonstrated better efficacy in PAH for relevant markers than ever previously seen. The important marker CO was not improved at all by Sotatercept. The onset (time from first dose to effects) of CS1 is also quicker. And the administration comes in the form of a pill instead of injectables, which is easier for patients. Furthermore, on March 27th, CNN writes this about Sotatercept: “In animal studies conducted before the human trials, the drug looked like it could do more than just treat symptoms: It seemed like it might be able to stop the thickening of the blood vessels and perhaps prolong patients’ lives, but those benefits have not been proven in humans.” Now back to what Dr. Raymond Benza has to say about CS1 on the subject: "Our effect on resistance was much more than what would be expected just with the effect in cardiac output. That means that this vessel is actually remodeling, and the resistance is coming down through a change in architecture of the vessel. That is really exciting to me".
Also, CS1 did all this in half the time compared to Sotatercept (12 vs 24 weeks).
A fluke? Interim findings are in and the answer is unequivocally no The apparent question surfaced - Exceptional results, but was this a one-time fluke? During fall of -23, Cereno announced interim findings (as a part of a DQCR) for 16 of the to be 30 patients including the following (in ""):

  1. "More than 60% of patients on CS1, all doses included, have a sustained reduction in mPAP." In other words, somewhere around 100% of the patients aimed for in a best case scenario.
  2. "An efficacy response compatible with a dose-response pattern." Being an open study, it would be logical to deduce that there seems to be three distinct differences in dose-response, as per the dosage protocol.
  3. *"Several patients with a reduction in mPAP of similar or greater magnitude as the initial Patient Case".*This speaks for itself.
  4. "The DQCR indicates an early onset of action". Patient #1 saw onset at 6 weeks but here is stated that "this early onset was observed already after 3 weeks for several patients". In comparison, onset for existing PAH medications apart from simple vasodilators is typically 12-15 weeks.
  5. "The DQCR showed a sustained reduction of mPAP in the 2-week follow-up period after the 12-week period of therapy with CS1 was discontinued." Indicating that a remodeling effect on the vessels has indeed taken place trough epigenetic modulation.
Again, the literature is clear; Patients with PAH just tend to get worse and simply do not see these results without intervention.
Cereno is granted "Compassionate use" by the FDA Having continued to demonstrate remarkable results also in the interim analysis, Cereno communicated to the market that they were now receiving even more inquiries from the clinics involved in the current study. This time stemming from a wish from both patients and treating clinicians to be able to continue with CS1 after the study ends. Expanded access/compassionate use, can be granted when faced with a severe condition where no good alternative medications exist, and if the FDA deems the demonstrated benefits as good enough. Cereno applied late -23. The FDA approved in January -24 and by this time Cereno also communicated that they now had been informed that the majority of the patients in the study would like to be able to continue with CS1. Apart from already being obvious exceptional news, this enables Cereno to generate a dataset for CS1 orders of magnitude more vast, since it will be possible to study even longer term results already now during phase II. As some may know, the dataset is everything when it comes to value.
Risks & critique What if the phase II study fails? CS1 and its pioneering approach has already been documented to show significant decrease in PAI-1 in human and has shown proof of concept in preclinical models in PAH by reducing the pressure in the vessels and achieving reverse remodeling. The company has also already communicated findings related to PAH for the majority of the patients in the current study which further support the findings seen in the preclinic. Look at them. Now do your own due diligence.
Why so cheap? The answer is probably twofold. First, although Cereno has operations in the US and the current study only uses US clinics, it is a Swedish biotech company still flying under the radar. There is a Swedish discord for the stock with some knowledgeable MD´s, scientists, etc. trying to explain what is going on but the majority of retail investors don’t seem to understand. Which brings us to second; institutional and professional investors typically enter post phase II results. According to Cereno, there is also already great interest from potential partners/buyers but the same goes here - phase II results first. The BoD and Management of Cereno have greatly increased their ownership exposure ever since presenting the results for patient #1 last year
Delay? Following Covid 19, there were administrative difficulties in starting up the nine clinics for the phase II trial resulting in the study being postponed and initial patient recruitment was also slow. To mitigate this, Cereno announced two additional clinics. The last of which should now be starting up at any time, since the company recently disclosed which one it is - Mt. Sinai Hospital, New York. Topline results are to be presented in Q3. The study is 12 weeks and had 26/30 patients enrolled by the last update in February. Hence, study completion could be delayed but given that only a maximum of 4 patients remain to be enrolled before end of June, it seems unlikely today. Since capital runway exists until spring -25, this should pose no vital threat regardless.
"Too much communication"? This is the only possibly negative feedback I've seen that has not yet been disproven. While I do think that many press releases in a short amount of time can sometimes pose more questions than they answer, in my opinion, this is not the case here. Having read them all, and while I do understand that not everyone is interested in which new country a patent has been accepted in or what events the the company will be attending, the rest is vital information. Cereno also sends copies of all press releases in English as well as Swedish, doubling the amount.
Wrapping up This only scratches the surface. If you are of a curious nature, maybe you will find interest in possible pieces to this puzzle such as that big pharma Bristol Myers Squibb (BMS) was engaged in buyout talks with Acceleron (Sotatercept) that was instead acquired by Merck. That Deepak Bhatt sits on the board of BMS - And now also in the SAB of Cereno.
But if nothing else, I think the following speaks for itself: The total addressable market (TAM) for PAH is projected to reach $12B by 2030.
The closest thing to a competitor (Sotatercept/Winrevair) was sold for approximately $7B after phase II. $8B today, adjusted for inflation. At the time of the acquisition, peak future sales was thought to come in at $2B. Since then, revised projections upwards of $9B have been made. The current market cap of Cereno Scientific is around $100M. Without speculating what a fair value should really be, that´s already a difference of around 80x. And compared to a lower peak sales than more recent projections. Plus, this is only from PAH, not counting thrombosis, with a TAM of 6x that of PAH. Cereno has already proven that CS1 can achieve results in PAH seen by no other therapeutic. And has already disclosed findings for the majority of the patients. The Phase II trial now only has a few patients left to recruit before completion.Cereno holds two additional candidates aimed at targeting thrombosis without bleeding, both seemingly unique and holding up so far. The TAM for thrombosis is projected to reach $70B by 2030. If Cereno replicates results for CS1 and PAI-1 a fourth(!) time, it would mean that their current PAH study also validates CS014 for thrombosis to quite some extent. Remember, they are both VPA. Bottom line – There are multiple shots at multiple staggering markets from one single study about to be completed – and the results so far are stellar.
submitted by Rahkrahk to Biotechplays [link] [comments]


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