Htc u.s. cellular

HTC

2010.03.02 20:24 dione1200 HTC

[link]


2010.06.08 15:03 NippleNutz Your android related questions here.

The place to get help for questions you have related to your Android device and the Android ecosystem.
[link]


2012.04.19 19:17 androidwiz HTC 10: Redefining What A Flagship Phone Is Truly Meant To Be

Discussion, news, tips, and tricks for the HTC One smartphone!
[link]


2024.05.19 12:19 DylSkiiii Picked up 2 x iPhone 8 on iOS 11.0 256GB & 64

Picked up 2 x iPhone 8 on iOS 11.0 256GB & 64
Still have 2 more to purchase. From a plug I’ve bought from before. Just opened the 64gb and confirmed running 11.0 new old stock. The 256GB will remain sealed. Check out my next post which will show the 64GB.
submitted by DylSkiiii to LegacyJailbreak [link] [comments]


2024.05.19 05:40 Cataclysmic98 What just happened? What's coming? The SEC filings & What if?

What just happened? What's coming? The SEC filings & What if?

What just happened?

We just relived the 6 months it took to the run-up of the sneeze of 2021 in just the last 3 weeks!
In late April GME rejected a hard low of $10.00 per share, then institutional buys appear to have started picking up, option calls were bought up starting a gamma like event, then Roaring Kitting came back (as we all know he did not trigger this event, nor was it retail suddenly coming up with a ton of new cash to suddenly pile into the stock).
We went from an average of roughly 3 million shares being traded daily to almost 800 million shares traded in just the last 2 weeks. We saw the stock rally to a near high of $80.00, with the Shorts throwing just about everything they had at their disposal to bring it down and prevent a squeeze.
GameStop is highly illiquid, with 75.3 million shares DRS by individual shareholders, Insiders holding 53 million, and Insitutional, Mutual Fund and ETFS holding 102.2 million leaving only 74.1 million shares unregistered for all other individual investors who cannot (registered accounts outside of the U.S) or have not DRS their shares. [Source reference DRSGME]. As of this Thursday May 16, 2024 the ORTEX FINRA reported shares on loan was 81.87 million shares. Reported Short interest was 64.23 million or 23.58% of free float and that percentage does not account for the DRS shares that cannot be borrowed against.

What's coming?

This video from the 33 minute mark does a good job explaining considerations for the coming weeks, with expectations for price holding around $20, tracking XRT regulation sho (a security will be placed on the threshold list if it has a significant fail to deliver position for at least 5 business days, and XRT is known to be used to short Gamestop), the June 6th OPEX tailwind on XRT, the implementation of T+1 settlement periods, GameStop's upcoming shareholder meeting, and execution of the recent SEC filings.
GME is positioned to fly again!
[Above is extrapolated from this video: https://www.youtube.com/watch?v=kUTto\_ykHTc. At a minimum watch from 33 minute mark for more details / explanation. \* Credit to 'roadapples' for first posting this link.]*
https://preview.redd.it/j27didtjya1d1.png?width=750&format=png&auto=webp&s=970193abe62c84b2ec96aadb8bdaaeaf82fbd5eb

What if? https://news.gamestop.com/sec-filings

FORM 424B5 Prospectus Supplement & S-3ASR Registration Statement Prospectus, Filed May 17, 2024:
F424B5 "Under this prospectus supplement and the accompanying prospectus, and in accordance with the terms of the Sales Agreement, we may offer and sell up to 45,000,000 shares of our common stock from and after the date hereof."
The media has of course spun this filing as negative and screamed 'dilution' of the stock. In generic terms this can be detrimental to the value of a stock for current shareholders as they now need to allocate the current company 'value' across an additional 45 million shareholders. However, GameStop has no debt outside of a 17 million dollar no interset covid-loan and over 1 Billion dollars in cash already on hand, so the proceeds used are not being used to pay off debt, but to inveset in the business towards improving profitabiity and value to shareholders.
The shares can be issued any time within the next three years. Consider if Gamestop were to issue the 45 million shares at an average of $60 per share. This would result in an additional 2.7 Billion in cash. Gamestop can invest this cash (with the existing 1 Billion, estimating 3.7 Billion at 5% for just GIC rates, this is a profit of 185 Million dollars a year profit on investments alone) and now has a huge arsenal at its disposal for acquisitions or other growth strategies for the long term viability and growth of the company.
S-3ASR This prospectus covers: "We may offer and sell, from time to time, one or any combination of the securities we describe in this prospectus. The preferred stock, depositary shares, warrants, purchase contracts, units and subscription rights may be convertible into or exercisable or exchangeable for our common stock, our preferred stock or our other securities."
With GameStop now being profitable they are in a position to issue dividends. However, until profit is larger and proven sustainable this does not make the best business sense. Plus, while expensive, Shorts can cover the dividend. This prospectus covers other options GameStop may capitalize on to reward their shareholders - and potential wipe out the Shorts.
A digital dividend, NFT-like unit, warrant subscription or carve-out (eg. of aquisition/invetment hold-co) is a consideration that could be Check.Mate for the Shorts!
There has been speculation of an NFT like dividend or WuTang like issuance being used as a unit distribution to shareholders of record. This cannot be replicated like a cash dividend by the shorts and could/should be checkmate - forcing the shorts to cover as they cannot procur the distribution. Alternatively, a warrant (guarantee to shareholders to acquire the right of additional shares at current price when shares are trading at a higher value in the future). Again, this warrant is provided to sharholder of 'record' only, potentially costing Shorts millions or billions of dollars, causing margin calls and forcing closure of Short positons.
May 17, 2024 prospectus: "We may issue units from time to time in such amounts and in as many distinct series as we determine. We will issue each series of units under a unit agreement to be entered into between us and a unit agent to be designated in the applicable prospectus supplement. When we refer to a series of units, we mean all units issued as part of the same series under the applicable unit agreement.
We may issue units consisting of any combination of two or more securities described in this prospectus. Each unit will be issued so that the holder of the unit is also the holder of each security included in the unit. Thus, the holder of a unit will have the rights and obligations of a holder of each included security. These units may be issuable as, and for a specified period of time may be transferable as, a single security only, rather than as the separate constituent securities comprising such units."
[**Note, this would mean that the newly issued units could not immediately be bought or borrowed to manipulate / cover missing positions of the new issue - effectively forcing the shorts to CLOSE their positions**]
The S-3ASR could mean a lot of different things. Regardless of timing or what happens next, I beleive in Ryan Chohen, the Board and and I'm nothing but exited for the outlook and prospects of GameStop.
Opinion only. This is by no means advice. Always do your own due diligence and invest to your individual risk tolerance.
For Fun: Bringing back the Hype!
The Big Squeeze: https://youtu.be/YhREEtWfeUQ
HOLD - The Gamestop Saga Soundtrack - The Real DMT: https://youtu.be/D_zFBnYdZiM
submitted by Cataclysmic98 to Superstonk [link] [comments]


2024.05.19 02:45 The_Brand94 RIGL Thesis 5/18/2024

~RIGL Thesis – 5/18/2024~
Outstanding Shares 175M
131 Institutional Holders
111,129,461 Total Shares Held
63.36% Institutional Ownership
Total Cash on Hand 3/31/2024 = $49.6M
Total Debt: $101.5M
Cash Burn Approximate = $8M per quarter (6 quarters of cash without any increases in revenue)
Q12023 REV = $26M
Q22023 REV = $26.8M
Q32023 REV = $28.1M
Q42023 REV = $35.8M
Q12024 REV = $29.5M (Decline from Q4 likely from end of year versus new-year tracking of Rx and shipments of drugs, resetting of Copays)
Most Recent EPS -$0.05 per share
May 22, 2024 - Vote on S will take place, caution
~Statistics Applicable To Thesis~
333.3 million US Population (2022)
8,109,679,892 Global Population (2024)
~Drugs On Market~
~Tavalisse – Treatment for ITP, FDA Approved April 17, 2018~
~What is ITP?~
Immune thrombocytopenia (ITP) is an illness that can lead to bruising and bleeding. Low levels of the cells that help blood clot, also known as platelets, most often cause the bleeding.
Once known as idiopathic thrombocytopenic purpura, ITP can cause purple bruises. It also can cause tiny reddish-purple dots on the skin that look like a rash.
Children can get ITP after a virus. They most often get better without treatment. In adults, the illness often lasts months or years. People with ITP who aren't bleeding and whose platelet count isn't too low might not need treatment. For worse symptoms, treatment might include medicines to raise platelet count or surgery to remove the spleen. Immune thrombocytopenia (ITP) - Symptoms and causes - Mayo Clinic
~What is Tavalisse?~
TAVALISSE is a prescription medication used to treat adults with low platelet counts due to chronic immune thrombocytopenia (ITP) when a prior treatment for ITP has not worked well enough. It is not known if TAVALISSE is safe and effective in children.
The cost for Tavalisse oral tablet 100 mg is around $15,404 for a supply of 60 tablets, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Tavalisse Prices, Coupons, Copay & Patient Assistance - Drugs.com
TAVALISSE IS AN ORAL MEDICATION TAKEN TWICE DAILY WITH OR WITHOUT FOOD1
A 12-week evaluation period is recommended
60 tablets = 1 month supply, evaluation period = 3 months, Cost for 3 months = $46,212 Cash, assuming cheaper through wholesale, insurance, discount cards, etc.
Dosing TAVALISSE® (fostamatinib disodium hexahydrate) tablets (tavalissehcp.com)
~Addressable Market~
“Our findings suggest that nearly 20,000 children and adults are newly diagnosed with ITP each year in the US, substantially higher than previously reported. Among patients requiring formal medical care, the economic burden during the first 12 months following diagnosis is high, with estimated US expenditures totaling over $400 million.”
Primary immune thrombocytopenia in US clinical practice: incidence and healthcare burden in first 12 months following diagnosis - PubMed (nih.gov)
The estimated prevalence of ITP in the United States is 9.5 per 100,000 people, with a global prevalence of over 200,000 people at any given time [1].
Immune thrombocytopenia. [ Oct; 2022 ]. 2022. https://rarediseases.org/rare-diseases/immune-thrombocytopenia
~Author Calculations/Estimates~
ITP estimated cases based on measured statistics 31,635 cases a year in the US and 770,355 cases globally each year.
~Rezlidhia – R Acute Myeloid Leukemia, FDA Approved December, 22, 2022~
~What is Relapsed or Refractory Acute Myeloid Leukemia?~
Relapsed, or recurrent, acute myeloid leukemia (AML) means the leukemia has come back after treatment and remission.
Refractory AML means the leukemia did not respond to treatment. Complete remission has not been reached because the chemotherapy drugs did not kill enough leukemia cells.
Both relapsed and refractory AML need more treatment to reach complete remission.
Your healthcare team will suggest treatments based on your needs and work with you to develop a treatment plan. Some factors considered for your treatment include:
your age
your health
how long the leukemia was in remission
treatments you had before
where the leukemia comes back
Treatment options usually include chemotherapy and a stem cell transplant if possible. Targeted therapy may also be used.
Treatments for relapsed or refractory acute myeloid leukemia Canadian Cancer Society
~What is IDH1?~
Somatic mutations in isocitrate dehydrogenase (IDH) genes occur frequently in adult Acute myeloid leukemia (AML) and less commonly in pediatric AML… Enhanced genomic and epigenomic profiling of acute myeloid leukemia (AML) has led to identification of recurrent mutations that are prognostic and are candidates for targeted therapy. Somatic mutations in isocitrate dehydrogenase (IDH) genes, IDH1 and IDH2, occur in ∼6% to 16% and ∼8% to 19% of adult patients with AML, respectively.1-5 In pediatric AML, IDH mutations are rare, occurring in <4% of patients.6-11
Characteristics and prognostic impact of IDH mutations in AML: a COG, SWOG, and ECOG analysis Blood Advances American Society of Hematology (ashpublications.org)
~What is Rezlidhia?~
REZLIDHIA is a prescription medicine used to treat adults with acute myeloid leukemia (AML) with an isocitrate dehydrogenase-1 (IDH1) mutation when the disease has come back or has not improved after previous treatment(s).
Targeted Treatment REZLIDHIA® (olutasidenib) capsules
The cost for Rezlidhia oral capsule 150 mg is around $17,468 for a supply of 30 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
Rezlidhia Prices, Coupons, Copay & Patient Assistance - Drugs.com%20is%20a%20member,on%20the%20pharmacy%20you%20visit.)
~Addressable Market~
The annual incidence of new cases in both men and women is approximately 4.3 per 100,000 population, totaling over 20,000 cases per year in the United States alone.[13] The median age at the time of diagnosis is about 68, with a higher prevalence observed among non-Hispanic Whites. Furthermore, males exhibit a higher incidence compared to females, with a ratio of 5:3.
Acute Myeloid Leukemia - StatPearls - NCBI Bookshelf (nih.gov)
~Author Calculations/Estimates~
Cases of AML with IDH1 would be 11% based on the median of statistics above (6% to 16%) leaving approximately 1500 to 2000 cases a year in the US. Appling the same calculations to world population would amount to approximately 38,500 cases a year globally.
~Gavreto – Treats RET+ Non-Small Cell Lung Cancer In Adults and RET+ Thyroid Cancer in Kids and Adults, FDA Approved August 9, 2023~
For the sake of common ground, I am going to assume these types of cancers do not need to be elaborated on as we all likely have a basic understanding of what they are. The medical conditions treated by Tavalisse and Rezlidhia I felt needed a more in-depth explanation because they are not common. I will elaborate on RET+ a little later in this writing.
~What is Gavreto?~
GAVRETO is an oral once daily prescription medicine used to treat certain cancers caused by abnormal rearranged during transfection ~(RET+)~ genes in:
Adults with non-small cell lung cancer (NSCLC) that has spread
Adults and children 12 years of age and older with advanced thyroid cancer or thyroid cancer that has spread who require a medicine by mouth or injection (systemic therapy) and who have received radioactive iodine and it did not work or is no longer working*
It is not known if GAVRETO is safe and effective when used to treat cancers caused by abnormal RET genes in children for the treatment of NSCLC or in children younger than 12 years of age for the treatment of thyroid cancer.
Home GAVRETO® (pralsetinib)
The cost for Gavreto oral capsule 100 mg is around $11,745 for a supply of 60 capsules, depending on the pharmacy you visit. Quoted prices are for cash-paying customers and are not valid with insurance plans. This price guide is based on using the Drugs.com discount card which is accepted at most U.S. pharmacies.
The recommended dosage for adults and children 12 and over is 400mg orally once daily. Each capsule is 100mg, which means you will take 4 capsules. Gavreto should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal.
Gavreto Prices, Coupons, Copay & Patient Assistance - Drugs.com
~What is Rearranged During Transfection Positive (RET+)?~
RET-positive cancer is caused by a mutation or abnormal re-arrangement of the RET gene. It occurs most commonly in lung cancer and several types of inherited and sporadic thyroid cancers. RET alterations also occur in an estimated 1-2% of multiple other cancers, including ovarian, pancreatic, salivary, breast, and colorectal cancers.
RETpositive Empowering Patients and Driving Research
Rearranged during transfection (RET) rearrangements were first identified as oncogenic drivers in NSCLC in 2012. The proportion of patients with NSCLC who have RET rearrangements (ie, fusion-positive disease) is approximately 1%-2%.
RET Fusion-Positive Non-small Cell Lung Cancer: The Evolving Treatment Landscape The Oncologist Oxford Academic (oup.com)
RET alterations occur most commonly in lung cancer (non-small cell lung cancer (NSCLC)) and the number of new cases diagnosed each year is considerable, accounting for approximately 37,500 [IG1] cases worldwide and 4,000 cases in the US (2% of NSCLC) (2,3). RET alterations are also common in several types of inherited and sporadic thyroid cancers and can occur in other types of cancers like ovarian, breast, pancreatic, and colorectal cancers, among others (4-8) adding >110,000 cases yearly worldwide (9).
What is RET Positive Lung Cancer? - The Happy Lungs Project
(2) Although medullary thyroid carcinoma represents 5-10% of all thyroid cancers, activating RET gene abnormalities occur in over 90% of hereditary and approximately 40%-60% of sporadic medullary thyroid carcinoma cases.
Patients – RETpositive%20Although%20medullary%20thyroid%20carcinoma,sporadic%20medullary%20thyroid%20carcinoma%20cases.)
~Prevalence of Non-Small Cell Lung Cancer~
Most lung cancer statistics include both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In general, about 10% to 15% of all lung cancers are SCLC, and about 80% to 85% are NSCLC.
Lung cancer (both small cell and non-small cell) is the second most common cancer in both men and women in the United States (not counting skin cancer). In men, prostate cancer is more common, while breast cancer is more common in women.
The American Cancer Society’s estimates for lung cancer in the US for 2024 are:
About 234,580 new cases of lung cancer (116,310 in men and 118,270 in women)
About 125,070 deaths from lung cancer (65,790 in men and 59,280 in women)
Lung Cancer Statistics How Common is Lung Cancer? American Cancer Society
Worldwide, an estimated 2,206,771 people were diagnosed with lung cancer in 2020. These statistics include both small cell lung cancer and NSCLC.
Lung Cancer - Non-Small Cell: Statistics Cancer.Net
~Author Calculations/Estimates~
Approximately 187,664 cases of NSCLC in the US based on an 80% factor.
Approximately 1,765,416 cases of NSCLC worldwide based on an 80% factor.
~Prevalence of Thyroid Cancer~
Rate of New Cases and Deaths per 100,000: The rate of new cases of thyroid cancer was 13.5 per 100,000 men and women per year. The death rate was 0.5 per 100,000 men and women per year. These rates are age-adjusted and based on 2017–2021 cases and 2018–2022 deaths.
Lifetime Risk of Developing Cancer: Approximately 1.2 percent of men and women will be diagnosed with thyroid cancer at some point during their lifetime, based on 2017–2019 data. Lifetime risk based on data through 2022 will available soon.
Prevalence of This Cancer: In 2021, there were an estimated 979,295 people living with thyroid cancer in the United States.
Thyroid Cancer — Cancer Stat Facts
About 44,020 new cases of thyroid cancer (12,500 in men and 31,520 in women)
About 2,170 deaths from thyroid cancer (990 in men and 1,180 in women)
Thyroid cancer is often diagnosed at a younger age than most other adult cancers. The average age when a person is diagnosed with thyroid cancer is 51.
This cancer is about 3 times more common in women than in men. It is about 40% to 50% less common in Black people than in any other racial or ethnic group.
Key Statistics for Thyroid Cancer American Cancer Society)
Addressable Market
Given Gavreto’s dual treatment capacity, the total amount of potential patients with NSCLC with RET+ indications would be approximately 2,800 cases in the US and approximately 26,500 cases worldwide each year using a factor of 1.5% of total NSCLC cases. The total amount of treatable cases for Thyroid Cancer would be approximately 650 in the US and 16,500 cases worldwide respectively each year applying the same 1.5% RET+ percentage rate. DOUBLE CHECK MATH…
~Rigel Pharmaceuticals Pipeline~
~IRAK/4 – Clinical Trials~
Rigel’s investigational candidate, R289, is an oral, potent and selective inhibitor of interleukin receptor-associated kinases 1 and 4 (IRAK1/4).
Toll like receptors (TLRs) and the interleukin 1 receptor family (IL-1Rs) play a critical role in the innate immune response and dysregulation of these pathways can lead to a variety of inflammatory conditions such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease. Chronic stimulation of both receptor systems has also been implicated in causing a pro-inflammatory bone marrow environment leading to persistent cytopenias in lower-risk myelodysplastic syndrome (LR-MDS) patients1.
R835 is a selective dual inhibitor of IRAK1/4 that blocks TLR4 and IL-1R-dependent systemic cytokine release. In preclinical studies, R835 demonstrated activity in multiple animal models of inflammatory disease2,3 and showed that dual inhibition of IRAK1 and IRAK4 provided more complete suppression of inflammatory cytokines when compared to an IRAK4-selective inhibitor4.
Development of R289:
In a Phase 1 clinical trial, R835 was well tolerated and inhibited LPS-induced inflammatory cytokine production in healthy volunteers, demonstrating proof-of-mechanism.5 Phase 1 clinical studies of R289 (an oral prodrug that is rapidly converted to R835 in the gut) are also complete.
A Phase 1b open-label, multicenter trial of R289 in patients with relapsed/refractory lower-risk MDS is currently enrolling (NCT05308264). The primary endpoint for this trial is safety with key secondary endpoints including preliminary efficacy and evaluation of pharmacokinetic properties.
~Bemcentinib – Bergenbio Partnership~
In June 2011, Rigel entered into an exclusive, worldwide research, development and commercialization agreement with BerGenBio for its investigational AXL receptor tyrosine kinase (AXL) inhibitor, R428 (now referred to as bemcentinib).
Bemcentinib is a potent, selective and orally bioavailable AXL inhibitor and the furthest along in clinical trials. In preclinical studies, bemcentinib was shown to have an effect as a single agent therapeutic in the prevention and reversal of acquired resistance to standard of care cytotoxics and targeted therapies and may also slow or prevent tumor metastasis.
Rigel received an upfront payment and is eligible for milestone payments and potential sublicensing revenue, as well as tiered royalty payments on any future net sales of products emerging from the collaboration.
~R552 Systemic – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies.
~Milademetan – Daiichi Sankyo Partnership~
Rigel has a long-standing collaboration with Daiichi-Sankyo for developing murine double minute 2 (MDM2) protein inhibitors in cancer, which were discovered in Rigel’s laboratories.
Preliminary safety and efficacy data from an early Phase 1 study of milademetan (formerly DS-3032), an oral selective MDM2 inhibitor, in hematological malignancies suggests that it may be a promising potential treatment for oncology indications.
Rigel received an upfront payment and is eligible for milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.
~Rxxx (CNS Penetrant) – Eli Lilly Partnership~
Rigel’s investigational candidates are oral, potent and selective inhibitors of receptor-interacting serine/threonine-protein kinase 1 (RIPK1).
RIPK1 is a critical signaling protein implicated in a broad range of key inflammatory cellular processes including necroptosis, a type of regulated cell death, and cytokine production. In necroptosis, cells rupture leading to the dispersion of cell contents, which can trigger an immune response and enhance inflammation. RIPK1 inhibition has therapeutic potential in treating autoimmune, inflammatory, and neurodegenerative disorders.
Rigel’s RIPK1 inhibitor program includes R552, a systemic molecule being developed for the treatment of autoimmune and inflammatory disorders, and brain penetrating RIPK1 inhibitors for central nervous system (CNS) diseases. In preclinical studies, R552 demonstrated prevention of joint and skin inflammation in a RIPK1-mediated murine model of inflammation and tissue damage.
Development of R552:
In Q2 2023, the initial Phase 2a trial (NCT05848258) in moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.
Development CNS-penetrating RIPK1 inhibitors:
Currently in preclinical studies. Pipeline :: Rigel Pharmaceuticals, Inc. (RIGL)
~Summary and Prediction~
The current share price of sub $1 does not feel justified. I would anticipate financial breakeven by the end of 2024 or potentially in Q1 or Q2 of 2025. The robust pipeline, progress, and expected revenue growth are enough to justify a much higher valuation. The debt load is manageable, but the potential for S is concerning. I believe that the S is not necessary and revenue growth and progress should speak for itself. I am not as bullish as the analysts at HC Wainright for a $15 PT, but the valuation should be at least 3x to 5x from the current value. This thesis does not highlight the patents surrounding their drugs either which some extend into 2035 and beyond. Perhaps what Wall Street is discounting is the fact that most of the drugs are very niche. However, the currently available drugs have an addressable market, albeit less universal than some, but you should value it in the sense of multiple facets (a 1000 headed snake is the phrase I wanted to use). I believe the company should be valued with specialty drugs in mind which would command a higher PE ratio. At the current day and time of writing, the value should be at least $1.50 to $1.75 ~at a minimum~ with a 12 month price target of $3 to $5+. I will be looking for continued revenue growth in each quarter this year and realization of revenue from Gavreto in Q2 or Q3 this year. The partnerships should not be discounted either and the current share price if it lingers here perhaps may attract a merger or acquisition. I initially began the research thinking that perhaps the drugs were too niche, but given the multiple drugs they are working with, I believe their revenue sources will continue to grow if you do not focus on one particular drug as the main performer. With the most recent inflation report being cooler than expected, I would suspect larger funds and institutions will be circling back to riskier assets.
submitted by The_Brand94 to u/The_Brand94 [link] [comments]


2024.05.18 20:48 SaturnIonFan Due to the amount of "what phone works with X carrier" posts, here's something I wrote about feature phones and American cell networks.

This is available with inline URLs and the one image that belongs to this piece on my website: https://konat.xyz/in_house/econobox_/cell_usa
"Using a feature phone in the USA: a brief guide to carrier activation and MVNOs"
This page is not meant to serve as an advertisement for any particular service or product, and has merely been written for informational purposes only.
Introduction
Unlike many other places in the world, the USA uses a completely different set of LTE bands for cellular communications, additionally, American carriers impose device restrictions, which may adversely impact uses of feature phones, as they often are heavily locked down to the carriers from which they came originally, or have to be imported. This guide simply outlines my experiences dealing with the three major carriers (AT&T, T-Mobile, and Verizon) and general assumptions about regional carriers (such as U.S. Cellular and Viaero Wireless).
AT&T
AT&T is potentially the worst provider for feature phone users, given that AT&T enforces a whitelist of devices which may be used on their network (PDF: read the whitelist on KONAT.xyz, mirroring the original on att.com), which impairs the use of feature phones as only a handful of models (mainly AT&T/Cricket branded [in-house] models, US-market Nokias, and rugged/work-oriented devices from manufacturers such as Kyocera). From experience, AT&T's enforcement of the whitelist is generally extremely strict, to the extent that your account may be suspended for using non-whitelisted devices.
Even if a device works on AT&T's network and is whitelisted, it may not have additional features (such as WiFi calling) functioning on the network. Additionally, carrier variants of devices (i.e. the variant sold by T-Mobile) may not be whitelisted. Below is a non-exhaustive list of MNOs/MVNOs which do and do not enforce the whitelist; this list may become outdated at any time.
AT&T uses LTE bands 2, 4, 5, 12, 14, 17, 30, 46, and 66. In my experience, bands 12, 17 and 2 are the most useful to have in urban areas. Band 14 is used for the First Responder Network Authority (commonly referred to as FirstNet). I would not advise using a device without complete band compatibility outside of urban areas.
ENFORCES WHITELIST: AT&T post-paid, AT&T pre-paid, Cricket Wireless (the prior three are all owned by AT&T). The vast majority of MVNOs can also be assumed to be enforcing the whitelist.
DOES NOT ENFORCE WHITELIST: H2O Wireless, FreedomPop, RedPocket GSMA
T-Mobile
In general, T-Mobile can be argued to be the best provider for feature phone users, as it does not enforce a whitelist, and generally allows any device with the LTE bands used in a particular area to function on the network and utilize VoLTE, WiFi calling, or other carrier functions. To further simplify this, this means T-Mobile will allow the use of imported devices which have the band(s) required to function in a particular area, as well as devices from other carriers, in addition to US-market unlocked devices and devices sold specifically for T-Mobile's network.
T-Mobile also operates an EDGE/2G network and small slivers of HSPA/3G. The EDGE network is moribund at best (and hasn't been expanded in well over a decade, nor does it appear to be a going concern maintenance-wise), and the remaining slivers of HSPA are officially meant to be offline. T-Mobile's legacy networks should not be depended upon for reliable communication.
T-Mobile operates on the following network bands relevant to feature phone users: EDGE/2G: 1900 MHz (PCS) LTE: 2, 4, 5 (only utilized in Myrtle Beach, South Carolina), 12, 66, and 71.
From experience, devices lacking any band other than B2 will work in urban areas, but B12 is generally needed for indoors signal. B71 is needed for good coverage in rural areas. As a resource for figuring out which bands are in use in particular areas, take a look at the band rollout map.
For reference, MVNOs which operate on T-Mobile include Mint Mobile, Ultra Mobile, MetroPCS (the prior three all are owned by T-Mobile), Tello, and US Mobile.
Verizon Wireless
I would personally rank Verizon as second-best for feature phone users, as Verizon generally allows any device with LTE band 13 to utilize their network. Verizon does restrict new activations, however, this can be bypassed by activating a new SIM card in a cell phone that is known to work with Verizon (such as an Apple iPhone or similar known-working device) and moving the SIM card to the B13-having feature phone (or other non-accepted B13-having) device after confirming that the activation went through successfully.
Devices without B13 may work in urban areas, but may not have voice or SMS functionality (limited to data only), thus, it is a necessity to use a device with B13. Additionally, some MVNOs on Verizon's network (the only one I know of currently is TracFone and associated brands [Simple Mobile, Total Wireless/by Verizon, Straight Talk, et. al.) may bind the SIM card to the device it was activated in, and in this case will likely suspend accounts for moving the SIM, even into another 100% functional device, thus making it impossible to use devices that require the above activation method.
Verizon uses the following LTE bands: 2, 4, 5, 13, 46, 48 and 66
MVNOs that operate on Verizon's network include TracFone et. al., Visible Wireless (the prior two are owned by Verizon), US Mobile, and Xfinity Mobile.
submitted by SaturnIonFan to dumbphones [link] [comments]


2024.05.18 16:13 GiversBot /u/CellularRevenge [REQ] was deleted from /r/borrow on 2024-05-18 (t3_pdx5rr up 992.95 days, LONGTAIL, ACCOUNT DELETE/SHADOWBAN)

CellularRevenge deleted from /borrow

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[REQ](1800$USD)-(#Morrow,GA,USA)-(Repay 2000$ 1k payments Oct. 1 Nov.1 Probably sooner), (PayPal,Cashapp)

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The payments would be two payments of 1k October 1 and November 1 latest but honestly I’ll probably pay it back sooner. My car was recently totaled and it’s like the second I solved that more problems came up. So you can make a quick 200 by November 1 latest but I’m going to stress again I can probably pay it back sooner I’m just being safe with the time frame. PM if interested.
Edit:Just thought if you want we can type up a virtual contract outlining the terms payments etc.
submitted by GiversBot to borrowdeletes [link] [comments]


2024.05.18 03:35 syntaxofthings123 Unpacking McLelands Response to the 4th Franks Hearing Motion

To sum up this "response", McLeland doesn't really respond to anything brought forward in the Defense's 4th Franks Motion. He sidestepped every issue.
And this wasn't the issue that the defense brought up in their motion, anyway. Defense motion was focused on the 4:33 am ping on February 14, not based on the location of Libby's phone, but how a phone that isn't responding to these pings, suddenly does--which again McLeland never addresses.
The location of that phone, if the State's theory is correct, would have to have been under Abby for that entire time. But if the two reasons a phone doesn't respond to this battery of pings from the Cellular Data Provider are that it is either not working or out of the area of coverage of the tower being used to ping, then there has to be something wrong with the State's theory that the girls were murdered by 3:30 on the 13th, and never left the spot where they were eventually found on the 14th.
That 4th Franks Motion was really all about the 4:33 am connection between an antenna on the Cell Tower and Libby's phone, which remains a mystery.
And interestingly, McLeland also does not mention the Magic Bullet, as was pointed out to me by someone in the comments!! Thank you Smart_Brunette. I had completely forgotten about that bullet--and apparently McLeland forgot about it, as well.
McLeland opens with:
That, as in the previous three Franks’ motions filed by the Defense, this fourth motion illustrates a complete misunderstanding of the ruling in Franks v. Delaware, 438 U.S. 154 (1978) and the purpose of a Franks’ challenge to a search warrant.
But McLeland only states what he means by this later in the motion. Just as a refresher, here is the key part of the opinion given in Franks v. Delaware
Held: Where the defendant makes a substantial preliminary showing that a false statement knowingly and intentionally, or with reckless disregard for the truth, was included by the affiant in the warrant affidavit, and if the allegedly false statement is necessary to the finding of probable cause, the Fourth Amendment, as incorporated in the Fourteenth Amendment, requires that a hearing be held at the defendant's request. The trial court here therefore erred in refusing to examine the adequacy of petitioner's proffer of misrepresentation in the warrant affidavit.
[Seems to me the defense has met this standard. Above and beyond the standard, even.]
Next:
The new topic that the Defense focuses on in the fourth Franks’ motion is the AT&T “pings”. The Defense includes in this motion information about pings generated by AT&T on February 13th, 2017 through February 14th, 2017. The Defense also includes statements made by Sergeant Blocher when he was consulted by Steve Mullins about the “pings”.
The information in the motion show that the Defense does not understand the information contained in the “pings” and then exacerbates the problems by mischaracterizing the statements by Sergeant Blocher.
[McLeland includes a lot of irrelevant information, or what I feel is an attempt to obfuscate, following this claim, but he does give some new information we haven't seen before.]
In our current case, when the girls went missing, law enforcement contacted AT&T and asked AT&T to “ping” the cell phone of Liberty German. This was done in an effort to locate the girls. The pings came in from AT&T every 15 minutes. That means that AT&T would send an email to law enforcement every 15 minutes showing the “ping” results of “pinging” Liberty German’s phone. Each “ping” will give a longitude and latitude of the device, with a radius estimate and the source of that data....
...If the tower cannot make cellular contact with the device then the “ping” data will show a historical data location.
[What exactly McLeland means by this isn't entirely clear. Is he saying that If for 10 & 1/2 hours the tower cannot make contact with the device, then it just keeps referencing historical data locations? Are these always the same historical data locations? Or do they differ? And what about the 4:33 am connection on 2/14 ? Was their historical data that came with that?]
(Also it is the antennas on a tower that do this-the tower itself is not sending signal, antennas are sending and receiving signal.)
McLeland continues on this theme:
A tower can lose contact with a device because the device runs out of power or because the device loses cellular service.
How is this different than what Blocher said? Here's Blocher's statement--
Sgt. Blocher advised that his interpretation of the information which we
were receiving from AT&T indicated that the cell phone was no longer in
the area, or no longer in working condition. He advised that since there
had been no change in the every 15 minutes update we were receiving and
the last known contact time had not changed since 17:44 hours.”
[Losing cellular service means the phone is no longer in the area.]
And then McLeland completely contradicts this here:
Sergeant Edwards later says “with AT&T, part of the reason why it says historical here is that if they say, all right, we’re going to ping that phone but they can’t get to the phone, well then they’ll use the last known location from the historical records.
So, that is different than the live ping; it’s going back to the historical records saying we can’t find the phone right now, but here’s where we know it was last.” The “ping” emails collected all show historical data. That means that the tower could not find the phone at the moment the “ping” was initiated, so it just gave the service provider the historical data location. That doesn’t mean the phone wasn’t in the area or that the phone wasn’t in working condition. It means that the tower could not contact the phone. That historical data continues through all the “pings”.
(If the two reasons a tower antenna can't connect to a phone are because it is either out of service or out of range, then one of those two factors had to be true about Libby's phone for 10 1/2 hours. And again, McLeland never addresses the 4:33 am call in this. Was that a live ping or not?)
McLeland goes on to write:
Sergeant Blocher reports that from his evaluation, the last contact that the phone had with the cellular tower was at 5:44 P.M. on February 13th, 2017.
[OK. so the 5:44 pm connection, or ping, was live! Good to know. But what about the the 4:33 am call?]
But then McLeland appears to contradict himself again:
AT&T show that there has been no contact with the tower since then. From that information, he determined that the phone was no longer in the area, or no longer in working condition. The Defense wants this to mean that the phone is not in the area from the evening of February 13th , 2017 until the morning of February 14th, 2017. That is not what it means. It means that since the “pings” were only showing the historical data location, the phone was not having contact with the tower. Sergeant Blocher explained that could be because the phone was not in the area, but it could also mean the phone was not working. This is consistent with the “pings” collected from February 13th, 2017 through February 14th, 2017. That the “pings” are giving an estimated longitude and latitude based on historical data location information not live “pings”.
Still no mention of the 4:33 am call on the 14th, and he's just repeating information he already gave.
And more non-information, information from McLeland:
This information is consistent with the information in the probable cause. The information that we have is that the girls were dropped off at the trails around 1:30 on February 13th, 2017 and that at 2:13 P.M. their kidnapper ordered them “down the hill”. There is no evidence that the girls were ever taken from the area or that they were brought back to the area later to be murdered. Every indication is that they were ordered down the hill and then murdered soon after. The historical location data from the AT&T “pings” does not mean the phone was not in the area during the evening of February 13th, 2017 until the morning of February 14th , 2017.
["The historical location data from the AT&T “pings” does not mean the phone was not in the area during the evening of February 13th, 2017 until the morning of February 14th , 2017." But it could mean this! McLeland has stated that it could mean this more than once in this one document.]
McLeland finally gets to what would warrant a Franks Hearing:
The State has outlined the test used in Franks in its prior responses. In order to have a Franks Hearing, the Defense’s attack on probable cause must be based on deliberate falsehood or acts of reckless disregard for the truth and those allegations must be accompanied by an offer of proof. The claim should point out specifically the portion of the warrant affidavit that is claimed to be false and should be accompanied by affidavits or sworn statements or reliable statements of witnesses. The Defense must show that there is inaccurate or omitted information, and that probable cause is lacking if the omitted information is included. Franks v. Delaware, 438 U.S. 154 (1978). Herein, the Defense claims omissions if included would negate probable cause for the Search Warrant of Richard Allen’s residence.
"In order to have a Franks Hearing, the Defense’s attack on probable cause must be based on deliberate falsehood or acts of reckless disregard for the truth and those allegations must be accompanied by an offer of proof."
[Right. And the defense has done just this.]
And last but not least:
Further, Richard Allen admits that he was wearing clothing matching the clothing that “bridge guy” was wearing that day. That along with other eyewitness testimony and the other evidence gathered establishes probable cause that Richard Allen is “bridge guy” and he is the one who kidnapped the girls.
"That along with other eyewitness testimony"
And this gets us to the very information McLeland never mentions in any of his responses--that Liggett lied about the eyewitness testimony. BB saw a young man on the bridge, no resemblance to Allen or BG & SC saw a man with only mud on his pants, wearing a tan not a blue jacket.
Basically, I feel that this response proves all claims made by the defense. It proves that the State not only misrepresented the facts of this case in all their PCAs, but continue to misrepresent the facts of this case in current motions. Obfuscation is the tool the State likes best, it seems.
Franks Hearing Please.
submitted by syntaxofthings123 to RichardAllenInnocent [link] [comments]


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submitted by Material_Baker8256 to Studentcorner [link] [comments]


2024.05.17 15:40 kittehgoesmeow What A Day: Commander-In-Beef by Crooked Media (05/16/24)

"If [Taylor Swift] ran for President and would listen to great advisers, I'd consider supporting her." - Ray Dalio, hedge fund billionaire, who praised Swift’s ability to bring people together.

Diss Tracks

We’re suddenly weeks away from the earliest presidential debate in U.S. history. If that seems unusual, you’re right — in more ways than one.
Let’s just hope the Biden campaign doesn’t have him walk out on stage to Kendrick’s “Not Like Us,” please.

Look No Further Than Crooked Media

We all make bad decisions sometimes, and although you probably have a group chat of friends to dissect what is going on in your life, understanding the nightmare-fuel that is Supreme Court decisions might require a law degree… or 3. So let Strict Scrutiny be your guide to this decision season. From abortion bans to Trump trials - law professors and hosts Melissa Murray, Kate Shaw and Leah Litman decode the drama and break down everything you need to know- and keep you sane in the process. New episodes release every Monday wherever you get your podcasts - And now on YouTube! Plus keep an eye out for bonuses, whenever SCOTUS tries to set the nation back 60 years.

Under The Radar

The Department of Justice vowed to crack down on threats to election officials, the kind that made the 2020 election so fraught and could make 2024 dicey as well. Trump’s stolen 2020 election narrative helped prompt hundreds of such threats. Four-in-10 local election officials say they have experienced threats, harassment, or abuse just for doing their jobs.
But the DOJ’s efforts may not measure up to the sheer size of the problem, according to the latest episode of this newsletter’s sister show, the What A Day podcast. Garland’s Election Threats Task Force has only brought 13 convictions since its inception in 2021. It’s far from clear how the DOJ will trace each threat back to its source. And this time, they’ll need to grapple with the rise of Artificial Intelligence, which could supercharge both the spread of misinformation and the reach of the worst people.

What Else?

Nearly a dozen MAGA faithful including Reps. Lauren Boebert (R-CO) and Matt Gaetz (R-FL) took more time away from working for their constituents to appear in Trump’s courtroom. The internet dunked on Boebert for attending Trump’s criminal trial, but not her son Tyler’s recent court date. Apparently blood is not thicker than that sweet, sweet MAGA juice.
Judge Juan Merchan is reportedly growing annoyed with the sideshow. The prosecution asked him to stop the entourage from entering court in the middle of questioning. We will all be very glad when this spectacle is finally over… which it will be. Hopefully. One Day. We think.
The House Judiciary Committee advanced an effort to hold Attorney General Merrick Garland in contempt of Congress Thursday after the White House refused to give up an audio recording of President Biden’s interview with the special counsel about his handling of classified documents. The White House seems to think Republicans want to take the audio, chop it up, and distort it for political gain. And, of course, they do. But voting to hold Garland in contempt effectively means asking Garland to arrest himself. Good luck with that one, fellas!
The North Carolina Senate voted to ban anyone from wearing masks in public for health reasons… as if the state isn’t still reporting hundreds of respiratory virus cases weekly including COVID-19! Republicans want to crack down on protesters in masks, accusing them of abusing pandemic protection to hide their identities. We know this is really just part of the GOP’s freaky little crusade against masks that is now entering its fourth year.
Cardi B is doubling down on revoking her support of President Biden in a new Rolling Stone interview, and to our disappointment, making a public stance that she is not voting for either candidate this year! Never thought we would see the day we disagreed with the iconic rap star but she has to “Be Careful” with her words and her influence. Sorry Cardi, we don’t like it like that.
A far-right Missouri secretary of state candidate might end up getting sued by rapper Lupe Fiasco for using his music in a diabolical ad featuring homophobic slurs. The ad shows candidate Valentina Gomez randomly running with an armored vest on before she blurts out: “In America, you can be anything you want. So don’t be weak and gay. Stay hard.” She even adds an F-bomb in there for good measure. Not sure what wearing a bulletproof vest for no reason and calling people gay has to do with being Secretary of State but hey, we’re not the * freedom * experts.
Gov. Greg Abbott (R-TX) said he will pardon a former Army sergeant convicted of fatally shooting a Black Lives Matter protester, citing the state’s “Stand Your Ground” law. A review board recommended Daniel Perry’s release after he was originally sentenced to 25 years in prison last year. Court records revealed Perry regularly shared racist memes and threatening content on social media, and now he will be back out on the streets thanks to Abbott. Perry’s firearm rights were also restored. Another winning day in Texas government!

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Light At The End Of The Email

The Justice Department is moving ahead with its plans to reclassify marijuana as a less dangerous drug. Reclassification wouldn’t legalize weed outright, but would federally recognize its medical use and take it out of the category with drugs like heroin and LSD. High five to that?
The Biden administration announced it will end coal leasing on federal lands in the Powder River Basin, which produces nearly half of the country’s coal in a region spanning 13 million acres across Montana and Wyoming. It’s a huge win for climate advocates pushing to restore an Obama-era moratorium on coal mining on federal lands.

Enjoy

Andrew Nadeau on Twitter: "I wish other jobs let us solve issues by releasing diss tracks. got some sick rhymes about debbie from accounting and her poorly structured invoicing"
submitted by kittehgoesmeow to FriendsofthePod [link] [comments]


2024.05.17 10:00 _luckybell_ Siri responds with “I’m afraid I can’t do that” When I try to confirm a calendar entry.

I am at a loss. I bought a refurbished Apple Watch Series 3 off eBay. the watch works/looks great. Set up went smoothly.
However, when I ask Siri to create a calendar appointment, the conversation goes like this: “Hey siri, add something to my calendar”, “What is the date and time of your appointment?”, “X date at X time”. Then the appointment preview pops up, with “Confirm” or “Cancel” buttons. I press “confirm”. Siri replies, “Sorry, I’m afraid I can’t do that”.
I have tried resetting my watch. I have checked all the settings I can think of to check. I have tried to find answers online. I am in the U.S., Siri should have no problems for me. Siri works just fine on my iPhone and Macbook Pro.
I do not have cellular data on my watch. Should this matter? I can make calendar appointments with Siri on my Macbook so I don’t see why that would matter in this case.
I bought this watch basically for the sole reason of making it more convenient to create calendar entries, reminders, and alarms. If i can’t figure this problem out I am going to return the watch. Can I go to the Apple store for help or do they only help you if you have purchased from them?
Any help would be very much appreciated thank you!
submitted by _luckybell_ to AppleWatch [link] [comments]


2024.05.17 02:53 minimumaxima Flares from CoQ10 demystified [How I hacked my flox — Personal Story]

Hello, everyone! It's been a while since I posted anything or even visited the sub. I do not visit the sub anymore as I collected all the information I needed long ago and staying on the sub only led to more thinking about flox. Focusing on other areas of life has been a great life hack for me! I have done a lot of positive things in the past half a year - I am starting my own business, been meeting new people and making a lot of new friends. Flox has changed me for the better.
I want to preface this by saying that I was probably the only person (or almost only as I've met maybe 1 or 2 other people on Reddit) who claimed flares from CoQ10. It actually flared me quite a lot — sometimes I could handle 100mg and sometimes even 30mg would lead to terrible pain. It was frightening to be one of the rarest cases in a pool of already rare cases, so, naturally, I tracked reactions to supplements extremely attentively (u/vadroqvertical won’t let me lie about that) and I have tried a lot (my cupboard is full of supplements — I spent around €3,500 on them in the span of 1.5 years). I will list reactions to supplements and the approximate timeline of when it happened:
— First of all, CoQ10/Ubiquinol flared me not so much 1 month out (tried 100mg ubiquinol multiple times) but it got worse as time went on to the point that April 2023 I could not even take 30mg without great pain. I tried it 1, 2, 3, 4, 5, 6, 8, 16 months out all without luck with varying doses flaring me to different extents. I will outline the reasons for it below;
— Vitamin E flared me a lot 2, 4, 6 and 8 months out. Never tried again. Tried 200-400 IU at a time. Due to poor GSH regeneration through Glutathione Reductase dependent upon B2 and NADPH;
— Benfothiamine flared me as well (doses 150mg-300mg/day). This is due to high sulphite and blockage of complex IV of the Electron Transport Chain in the mitochondria the reason for I will explain further. Thiamine is easily broken down by sulphite in the body and it is broken down into sulphite as well, which causes a negative loop reaction in people with high sulphite levels. Benfothiamine also caused me a severe allergic reaction (extreme anxiety and itching) that gladly did not require hospitalisation but was extremely scary and scarred me psychologically (likely high sulfocysteine activated NMDA receptors);
— Vitamin B6 increased my neuropathy when I got it. Likely due to poor B2 functional status. The problem I was also deficient in B6 and its supplementation led to great improvements in sleep quality once I could tolerate it. Note B6 is easily destroyed by sulphite just like B1;
— Riboflavin flared me (tried at 100mg, doses under 10mg never flared me). This is likely due to unmatched NADPH supply due to high sulphite load in the body (speculative);
— Astaxanthin greatly improved my physical health at 5-6 months out (proving that the core of my issues was solely ROS) but it caused reductive stress (NADH accumulation), which also caused pain, albeit the pain was a different kind and asta caused worsening neuropathy and visual snow. It accumulates in fat tissue, so stopping it was nice with ROS coming to a balance at about 10-12 days after discontinuation (after a loading dose of 36mg/daily for 3.5 weeks) but ROS then came back after it went out of the body further. I did not retry astaxanthin as I realised it caused me reductive stress and neurological issues;
— NAC helped me a damn lot. It was the best antioxidant for me. The problem is it depleted my molybdenum and copper and started giving me allergic reactions (low molybdenum + copper as well as blocked complex IV will lead to way higher sulphite generated from NAC);
— Did not feel much from vitamin D. I live in a very sunny country and tested at 51 (ref. Range 30+) without any supplements;
— Magnesium helped me a lot. #1 supplement;
— Calcium did not help me much in the beginning, actually, caused me heart palpitations. Was fine taking it after a few months;
— Potassium was a good supplement. I took 800mg/day for a while and it supported my muscle health;
— Important: vitamin B5 made me feel a lot better. It took my ROS down like crazy — I could feel normal muscles again, it removed my oxalate pain completely, too but for only a short while like 3-4h.
I have tried many more supplements that were phyto-supplements and such and none of them really helped me beside maybe some placebo effects. Some made me feel worse and were not worth it at all. I did not try anything mood-changing as I was not interested in it. To note, GABA supplement made me feel a little euphoric at first.
It is very relevant that I have been oxalate dumping since 27 Dec. 2023. The description of the experience can be found here: https://www.reddit.com/floxies/comments/1by0uh0/comment/kyma718/
Now, to the real question: why did CoQ10 flare me even at high nutrient status (just after flox). I have to stress that flares from CoQ10 were much less at the beginning of flox likely due to better nutrient status (it went from extremely terrible to slightly more extremely terrible while 6 months out it went from ‘eh’ to terrible).
  1. First, I have to say that NAC made me worse long-term. How? Over a long period of time I was taking it and was not watching my copper levels (NAC increases metallothionein and causes poor copper absorption) and molybdenum levels (NAC raises generation of sulfite and it needs molybdenum to be detoxified). Some NAC formulations have molybdenum in them but I was not lucky to get one of those and, due to lack of knowledge, did not supplement any molybdenum. The result was high sulphite and from that high ROS (with a combo of benfo which further increased sulphite it caused me peripheral neuropathy at 5 months). Sulphite causes Fenton reactions when complex IV gets blocked up. H2S (a signalling molecule and a vasodilator) also needs to be detoxified by a CoQ-10 dependent enzyme and turned later into sulphite and then sulphate by molybdenum and complex IV (dependent on copper) and if it is not detoxified, it causes a complex IV blockage and starts Fenton reactions as well as electron leakage during production of ATP, causing ROS. This causes a negative feedback loop that was described in the linked article as follows:
«This can be explained as follows:
1) hydrogen sulfide inhibition of complex IV generates superoxide in the respiratory chain, which becomes hydrogen peroxide,
2) hydrogen sulfide reduces ferric iron to ferrous iron, which makes it release from storage in ferritin,
3) this increases Fenton reactions between free iron and hydrogen peroxide, which generate more dangerous reactive oxygen species like the hydroxyl radical,
4) all of this deplete glutathione,
5) since a major purpose of the trans-sulfuration pathway is to provide enough cysteine to make glutathione, glutathione depletion hyperactivates the trans-sulfuration pathway, leading to more cysteine availability, the excess of which is catabolized to sulfite by alternative reactions that do not produce hydrogen sulfide and therefore do not require CoQ10.»
  1. In the article linked below, you will see that CoQ-10 protects against reactive oxygen species mainly due to improving hydrogen sulphide clearance (H2S). Therefore, CoQ-10 deficiency did not cause much ROS in complexes I and II but mainly produced issues in Complex III (where sulphite detoxification starts) and complex IV (where the last electrons are delivered during the sulphite-sulphate reaction). Excerpt: «In human cells with CoQ10 synthesis defects from the same study, CoQ10 protected against reactive oxygen species, but suppressing the enzyme that uses CoQ10 to clear hydrogen sulfide abolished this effect. This shows that the reactive oxygen species were coming from poor hydrogen sulfide clearance.»
Considering this, and oh my god, finding this article was like god sent it to me: my CoQ10 flares were coming from poor hydrogen sulphide clearance. At that point there were multiple reasons this could be happening:
  1. Cellular CoQ-10 deficiency;
  2. Manganese toxicity;
  3. Copper deficiency;
  4. Molybdenum deficiency;
  5. SUOX (enzyme which converts sulphite to sulphate) or another genetic impairment;
  6. Blockage of complex IV by something else.
I checked my molybdenum and copper transporting genes, SUOX using DBSNP and my AncestryDNA.txt file, and they were all good (Yes, I know Ancestry does not do a full genomic profile but it still had the main SNPs for that.). I also checked my manganese transporter genes and seemed I was homozygous for an important one but fine with others. It is really hard to estimate how that might affect you IRL, perhaps that would require a real genetic counsellor (or lots of hours spent ruminating again). I also did not think I had any genetic issue since I was very very healthy all my life and had 0 pain or health issues before flox occurred (I have extremely healthy young looking parents that drink, smoke and do whatever they want and have 0 consequences to their health as well).
I took some tests, for example: Genova NutrEval at ~6 months out, full nutrient blood test panel at ~11 months out (abstained for 35 days from any supplements at all, even vitamins and tested literally everything, paid around €1,200) and my CoQ10 levels at both of those occurrences were at 1 & 1.07 in absence of supplementation with ref. Range 0.8-1.4, so it was definitely not low. That way I eliminated #1 and #5. While I was not entirely sure whether genetic issues had to do anything with it, I decided to pretend like they didn’t, since I had to try out other solutions before jumping to the most complex one. I took a lot of molybdenum, so molybdenum deficiency was not at the table for me. In this way I was left with #2, #3 and #6. In the full blood panel, my manganese was slightly high (20.1 with ref. Range <~18) and the SNP people were talking about that caused them manganese toxicity was homozygous for me, so I definitely considered it but manganese when supplemented made me a feel a lot better, actually (mentally, not physically), so I was also likely deficient in it. For now, I just avoid it in supplemental doses but I do not avoid foods containing it. Besides, I do not have iron overload genes that could contribute to manganese toxicity.
I could not take copper because it would lead to high ROS immediately (due to complex IV blockage the reasons for which I will outline further). Considering manganese was likely deficient and not superfluous, I discarded reason #2 and reason #3 could not be fixed by copper, so it was definitely not only copper deficiency but either another factor or another factor coupled with copper deficiency. I was stuck for a long time until I found another article from the same author about B12 and B9 helping to detoxify oxalate. As I said before all this explanation, I have been oxalate dumping throughout the whole process (already 4 months). I should note I was oxalate dumping even before I got floxed (I likely had oxalate overload to my appendix surgery — this is proven by inflamed mesenteric lymph nodes confirmed by 3 MRIs — Sally Norton has the same case of over-absorption in her book) and that is how I actually got the E. Coli they gave me Cipro for (oxalate crystals create a good environment for it in the urinary tract lol) and how I got floxed (I went full circle, lmao). When I was floxed, I was not oxalate dumping for at least a year likely because my body was not in the state to handle the dumping process but it was still affecting me as I will outline further. First of all, I want to say that biotin actually promoted dumping for me as said in the article and not relieved it like it is said in Sally Norton’s book (I am not sure if there is a genetic variation to this). The proposed mechanism of oxalate detoxification in the article is as follows:
«Recall my proposed two-step detoxification process:
  1. Pyruvate carboxylase [biotin-dependent] converts oxalate to formate.
  2. Formate is joined to tetrahydrofolate to enter the methylation cycle, be used for the synthesis of purines or DNA, or be converted to carbon dioxide and exhaled in the breath.»
This are also very important words: «There may be more regulation layered on top of this to prevent excessive formate accumulation. It would certainly be preferable to have oxalate crystals cause pain or disrupt the skin than to have formate accumulate beyond the capacity to clear it.» This is why I felt best when dumping. Could eat anything, drink beer, even smoked weed once without issue. Another time though I got too brave, smoked a lot of weed and got a very bad ‘relapse’ but recovered quickly from it. The next morning when using a towel after a shower I had the same pain I used to have 2.5 months out from Cipro (which was extremely bad and took me back 14 months in memories) while before I smoked weed that second time I had almost 0 tendon pain in my daily life apart from oxalate [Here I thought maybe I and DrHungry share similar issues then? He also had an extreme (same in intensity relatively to his flox journey) flare from weed and is also using a lot of sulphur-based antioxidants still. Could such weed flares be related to complex IV dysfunction and/or impaired sulphite clearance?]. In either case, I felt best when dumping, probably because my body was able to regulate formate accumulation and ROS production greatly reduced at those times.
I was sitting outside with my parents and their friends, researching my flox issue when I read these lines: «Formate accumulation is the principle mechanism of methanol toxicity. Part of its toxicity is driven by inhibiting cytochrome oxidase, complex IV of the mitochondrial respiratory chain, which would inhibit the clearance of sulfite and hydrogen sulfide and block the production of ATP.» It finally clicked. It was honestly one of the best moments in my life when I realised. I made the connection between great improvement from B5, formate accumulation, issues with copper supplementation, general ROS improvement and oxalate everything together. Suddenly, my whole flox journey became crystal clear to me.
B5 is mainly used in the body to create Coenzyme A. An intermediate molecule in the production of CoA is called 4’-phosphopantethine and is used in the enzyme 10-methyltetrahydrofolate dehydrogenase (high formate will pair with THF and form 10-MTHF in the attempt of the body to detoxify formate). This enzyme converts 10-MTHF back to THF and creates NADPH in the process which is used by Glutathione Reductase to regenerate Glutathione. Hence, high-dose B5 led to a lot of those reactions occurring and me feeling a big relief from ROS AND OXALATE, so oxalate is indeed detoxified into formate by biotin-dependent pyruvate carboxylase.
Okay, so theory is very interesting but what is theory if it has no proof? When I read it, I realised I finally cracked my flox but I had to get real proof.
Just a few weeks before this, I drank some wine and got nerve damage (likely from high sulphites in it, again, duh — while this was a terrible experience, it played a role in me getting closer to the solution of my issues). Beer caused me no issues, could drink 10 or more bottles in one sitting, eat a lot of rice with no issue. Before, I had only numb hands and top of feet. After the wine, I had burning up to the knee and burning in palms and behind my shoulders. I got fed up with this, I just decided to methylate the fuck out of my nerves and eat copper not in supplements but from calamari (very high in copper but low in vit A, so no toxicity risk like from liver). At that time, I was dumping and my ROS was not too high. I started consuming around 200g protein per day, eating a lot of copper 3-4mg/day and my nerves really healed a lot. To the point they even became normal after 3-4 days. My vision became brighter, it was absolutely crazy. I was also supplementing 150mg molybdenum/day. After a week of that, though, I started getting ROS back and it was very bad ROS, like almost a year ago when I had low molybdenum and copper from a lot of NAC use. That confirmed my suspicion that my issue was indeed sulphite. Eating almost anything caused ROS for me, dumping stopped since the body had no free reducing agents (NADPH) to support sulphate-producing enzymes (oxalate is transported on sulphate transporters, so it literally could not drive out of the cell because it had no car lol). As you understand, high ROS prevents a lot of enzymes from working and here it causes, as you have probably understood, a negative feedback loop.
So, back to the proof. Since I realised that my issue is probably formate, I just decided to take high-dose B5 again (did not add any high dose B2, B1 or other B vitamins, just took my usual B complex with food). It really helped me a lot, again. I felt almost normal. Then, it caused me some pain but I felt how I was getting better and the next day I took it in the day, then in the evening I ate around 80g carbs and took double the dose of B complex (my B complex has low doses: 10mg B1, 10mg B2, 25mg B3, 20mg B5, 5mg B6, 100mcg B7, 100mcg B9, 50mcg B12) instead of adding a lot of B5 and boom, no pain and oxalate dumping restarted quite more strongly than it even used to be before megadosing protein. So I was in pain for at least 2 weeks dying from ROS and then 2 days of B5 and suddenly I was normal again? It felt like paradise. The next day, I went out with my friends. I was a little nervous since we were going to eat out and we ordered 600g of carbonara (the portions here were huge there). I ate it all at once with 2x my light B complex and guess what happened? NO PAIN, just oxalate dumping. I finally realised that I was right and detoxified formate unloaded my complex IV, allowed sulphate transporters to be created, reduced ROS production from food and suddenly I felt like a normal human being (except the dumping part). I recently retried CoQ10 — no flare. Likely before formate got recreated a lot because I was dumping a lot (if you read my comment, you will understand).
I am not megadosing B5 right now but just stuck to 80-100mg B5 per day, so 4x my light B complex as my B6 tolerance improved a lot. Why I am not megadosing B5 is because oxalate likely blocks conversion of vitamin B2 into its active forms as I at ~11 months out when I did full-testing in the absence of supplementation 35 pre-testing had high molybdenum, iodine, (almost above the ref. Range (113 with ref. Range <120) selenium and very high B2 even though I was cellularly deficient according to Genova NutrEval (at 356 with ref. Range <295).
Hence, we can understand what happened to me from the beginning:
  1. Oxalate overload led to formate overload as oxalate is converted to formate through the action of biotin-dependent pyruvate carboxylase;
  2. Formate overload led to complex IV blockage, high ROS and high sulphite, which also leads to high ROS and also leads to complex IV blockage (negative feedback loop);
  3. High sulphite destroys vitamins B1&B6 as said in the beginning, which caused endogenous production of oxalate to skyrocket (you can read about this if you google, this information is very available);
  4. Hence sulphate transporters also got impaired, oxalate detoxification in the form of physical crystals also halted, which led to even higher overload;
  5. This led to higher formate, this led to even more ROS.
Mega-dosing B vitamins and especially B5 and B9 led to formate detoxification and the ability of my body to detoxify oxalate. This improved me a lot and it definitely feels like it will inevitably lead to my recovery. I feel good now, I still have some remaining neuropathy but it’s minimal and I know what to avoid to not make it worse and how to improve it quickly if I need to. I have no OS from beer, coffee or food. Also, I am dumping a lot right now. You can ask me all kinds of questions that you want and I will try to answer them to my best ability since I know what it is like to be floxed and I will help anyone who is in the same situation. I am only 22 years old and this experience led to me rethinking my whole life. I plan to become an extremely rich person to be able to fund biochemical research in the future and will focus specifically on floxed individuals and I will help floxed people first. I will try to reach my goals as fast as possible, I promise.
I hope this post does not get removed by moderators. If there is anything to moderate, change, or add, I will be happy to do that. All I say here is very attentively selected and fact-checked either from external sources or personal experience. I do not lie and have no motivation to do so. I am only trying to share my knowledge and to help realise others flox is not unbeatable and can be understood and solved — it all depends on individual factors.
Linked articles:
Manganese Toxicity Is a CoQ10 Deficiency
https://chrismasterjohnphd.substack.com/p/manganese-toxicity-is-a-coq10-deficiency
CoQ10 Deficiency Is Sulfur Toxicity
https://chrismasterjohnphd.substa2ck.com/p/coq10-deficiency-is-sulfur-toxicity?utm_source=profile&utm_medium=reader
10-Formyltetrahydrofolate dehydrogenase
https://lpi.oregonstate.edu/mic/vitamins/pantothenic-acid#formyltetrahydrofolate-dehydrogenase
Can Biotin Help Detoxify Oxalate?
https://chrismasterjohnphd.substack.com/p/can-biotin-help-detoxify-oxalate
Can B12 and Folate Help Detoxify Oxalate?
https://chrismasterjohnphd.substack.com/p/can-b12-and-folate-help-detoxify
submitted by minimumaxima to floxedtreatment [link] [comments]


2024.05.17 01:47 MtHoodlum Exclusive T-Mobile, Verizon in Talks to Carve Up U.S. Cellular

Longer Summary of Article:
U.S. Cellular, one of the last major regional wireless carriers in the United States, is in discussions with T-Mobile and Verizon to sell parts of its operations and spectrum licenses. This potential split sale aims to appease antitrust authorities by ensuring that the transaction does not negatively impact competition. The sale would give both T-Mobile and Verizon access to valuable airwaves, with T-Mobile expected to finalize a deal worth over $2 billion by the end of the month, while Verizon's negotiations are still ongoing and may not result in an agreement.
U.S. Cellular, headquartered in Chicago and majority-owned by the Carlson family's Telephone & Data Systems, has faced increasing competition from larger national carriers and cable-broadband providers. The company's spectrum portfolio spans 30 states and covers approximately 51 million people, making it an attractive asset in the wireless industry, particularly as the Federal Communications Commission (FCC) has not auctioned new spectrum for over a year, causing existing spectrum licenses to rise in value.
The wireless industry in the U.S. has seen significant consolidation, reducing the number of players to Verizon, T-Mobile, and AT&T. T-Mobile, which became the second-largest U.S. carrier after acquiring Sprint, continues to expand its customer base, recently completing the purchase of Mint Mobile. U.S. Cellular provides service to over four million customers across 21 states and owns more than 4,000 cellular towers, though these towers are not included in the current sale talks.
The driving force behind this deal is the rising value of wireless licenses, particularly those capable of supporting 5G signals. American companies have invested over $100 billion in recent years to secure these airwaves. However, the FCC's lack of authority to auction new spectrum has heightened demand for existing licenses.
The U.S. wireless market has matured, with most adults and many children already subscribed to smartphone services, limiting growth opportunities. AT&T and Verizon have refocused on their core cellphone and home-internet customers after retreating from the media business. As U.S. Cellular is one of the few remaining regional carriers, it has long been considered a potential acquisition target in the industry.
Overall, the potential split sale of U.S. Cellular to T-Mobile and Verizon represents a significant shift in the U.S. wireless landscape, driven by the high value of spectrum licenses and the ongoing consolidation among carriers. The outcome of these discussions will likely impact competition and service offerings in the industry.
Expanded Summary of Comments:
The comments on the article about the potential split sale of U.S. Cellular to T-Mobile and Verizon reveal a wide range of opinions and concerns from readers, reflecting the complexity and impact of such a deal on consumers and the market.
  1. Positive Experiences with Alternatives:
    • Some commenters express satisfaction with alternatives to major carriers. For instance, Chip Burgess mentions switching to T-Mobile’s 5G home internet combined with YouTube TV to avoid high prices from Comcast, highlighting the benefits of competition brought by T-Mobile.
  2. Competition and Market Dynamics:
    • Matty G underscores the importance of competition, noting how T-Mobile disrupted the previous duopoly of AT&T and Verizon, which benefited consumers by lowering prices. He raises concerns about the potential for reduced competition if another major player doesn't emerge, such as Amazon, Google, or Apple.
    • Others, like Michael C, emphasize the need for more competition in the cellular industry, worrying that further consolidation will harm consumer choice and service availability, especially in suburban and rural areas.
  3. Service Quality and Pricing Issues:
    • Several comments address dissatisfaction with service quality and pricing from major carriers. Mel A discusses inconsistent signal strength between Verizon and T-Mobile in different locations, indicating frustrations with coverage reliability.
    • Brian Egbert reminisces about the breakup of AT&T and Bell Labs, suggesting that deregulation initially lowered prices and increased consumer choice but also led to service issues and market monopolies.
  4. Regulatory and Antitrust Concerns:
    • There are strong opinions about the role of government regulation and antitrust enforcement. Jim Fowler questions the current state of monopoly control in the U.S., implying that regulatory bodies should scrutinize such mergers more closely.
    • John Reilly points out the potential anti-competitive nature of T-Mobile and Verizon carving up U.S. Cellular, suggesting that it could violate the Sherman Antitrust Act and calling for stricter regulatory oversight.
  5. Impact on Rural Areas:
    • Joseph Muscato highlights the importance of U.S. Cellular in rural areas, like rural Missouri, where it often provides the only reliable signal. He questions whether major carriers will maintain service in these less lucrative areas and whether the FTC will require them to do so.
  6. Historical Context and Industry Trends:
    • Commenters like Joseph W. Kelly reflect on the historical trend of industry consolidation, where numerous players eventually merge into a few dominant ones. He suggests that this is a natural progression but raises concerns about potential price increases and service quality.
    • Others, such as Wayne Longman, criticize the current spectrum allocation system, suggesting that the FCC's management of spectrum auctions has contributed to the consolidation and inefficiencies in the market.
  7. Technological and Future Considerations:
    • Discussions also touch on future technological developments and their impact on the market. Brandon Purnell mentions Starlink’s potential entry into the cellular market, speculating that SpaceX might eventually operate independently, which could further disrupt the industry.
    • Commenters like Michael Smith and Longman discuss the capital-intensive nature of the wireless industry and the challenges of building a nationwide 5G network, proposing ideas like government-managed duopolies to ensure comprehensive coverage.
  8. Personal Experiences and Advice:
    • Many comments share personal experiences with different carriers and plans, offering advice on how to find better deals. For example, Charlie Roast recommends Metro by T-Mobile for cheaper rates, and Gregory Sdrocer highlights low-cost options like Visible Wireless, a Verizon subsidiary.
  9. Skepticism and Criticism:
    • Some commenters express skepticism about the proposed merger's benefits, with David Hartner arguing that the real goal is to reduce competition and increase pricing power rather than achieve economies of scale.
    • Heath Anderson and others voice frustration with constant billing issues and the feeling that loyal customers are not rewarded with better prices, indicating a broader dissatisfaction with customer service practices in the industry.
Overall, the comments reflect a deep concern about the potential reduction in competition and its impact on service quality and pricing. They highlight the challenges of balancing market consolidation with the need to maintain consumer choice and protect underserved areas. The mixed reactions underscore the complexity of the wireless industry and the varied experiences of consumers.
submitted by MtHoodlum to outdoorwireless [link] [comments]


2024.05.16 22:02 ConnectionGuy2022 Airsense 11 - Personal Therapy Assistant

Hi,
My understanding is that Airsense devices can only connect to cellular network in the U.S.
Since Personal Therapy Assistant feature is using myAir app as the interface, I imagine that it works only in the U.S.
It's difficult to believe that Resmed created features that only works in the U.S., considering this machine is sold worldwide too.
Can anybody who owns Airsense 11 who live outside of the U.S. fill me in on this? How was your experience with it?
submitted by ConnectionGuy2022 to CPAP [link] [comments]


2024.05.16 21:09 remixserpent Samsung Galaxy Tab S8+ or alternatives

So long story short I bought a Tab S8+ 128GB 5G on Amazon renewed. I love the AMOLED screen but there have been issues with each order. The first time it had screen burn-in and the tablet was still tied to Verizon. I ordered a replacement and this time there was no burn-in, but it is still tied to Verizon because it probably wasn't paid off. I paid right at $400 for it. I am wondering if I should just deal with it at this point.
My alternate question in case if I really wanted to do this is what tablet would you guys recommend as an alternative? I use the tablet for running emulation like the switch or 3DS, also media consumption, general gaming, and note taking. I heard some good things about the Xiaomi Pad 6 Pro, but I'm not sure about longevity or how well it works in the U.S. the tablet doesn't need to be cellular, just would've been a plus at the price I paid.
submitted by remixserpent to androidtablets [link] [comments]


2024.05.16 19:06 No_Competition7327 Human or not? (Part 1)

I woke up blindfolded tied to a chair. They had tied up my hands and legs so I couldn't move. I didn't know where I was exactly but I knew it had to be one of their offices.
"So Jason, You finally got caught. You've been giving us a lot of trouble lately you know?" said a female voice in front of me.
"Where am I and who are you?" I asked
"I'm gonna be the one asking questions here , We both know what you did so let's cut to the chase. Where is the pendrive?" the voice said.
"Do you really think I'm going to tell you? I don't even know you , One thing I can tell you is that pendrive had some really interesting stuff on there" I replied.
"You don't have to make it any harder for us or you Jason. Just tell me where it is and we can be on our way" the voice said.
I started laughing hysterically, There were other noises from behind me which made me realise there were more people there than I thought.
"If I tell you where the pendrive is , You'll have no use of me anymore and will dispose of me. Won't you?" I questioned back.
"It didn't have to be this way Jason" the voice said before I heard footsteps coming closer.
BANG
There was suddenly a banging sound , There started to be noises of panic around me.
BANG BANG BANG
The banging sound started getting louder and louder . The noise around me started getting higher.
I took the opportunity to make my chair fall. Finally my blindfold fell off my face.
I was in a white room surrounded by people with guns. They seemed to ignore me and discuss something else.
There was suddenly another loud sound followed by the sound of a huge metal thing dropping.
"SHOOT HIM" commanded the voice.
There were a lot of gunshots fired then. I couldn't see what they were shooting at because I was still tied to the chair. The sound of gunshots were soon replaced by screams and the smell of blood.
"Are you alright Jason?" a familiar voice called out to me.
The footsteps of the person got closer and soon I was able to see his face.
"Tracey?" I cried out
Tracey then started untying me. "I received a message saying you were in trouble ,so I came to help" he explained.
"A message by who?" I asked him
"I don't know , They called themself DS" He replied . The ropes were finally untied and I could move freely.
"Here , take this. It'll help us stay in contact." Tracey said to me as he tossed a phone to me. It was fully charged and had his number saved. It also had a sim-card installed with cellular data.
"Now let's get out of here, Uh ignore the bodies" he said to me.
The room was filled with blood and dead bodies. It was truly a massacre.
We started leaving through the doors Tracey broke through. But we were quickly intercepted by more armed people.
"This way!" I exclaimed running the opposite way of where he came from. He started following me.
"Where does this lead?" He asked
"I don't know , Somewhere where there aren't armed people trying to shoot us hopefully" I replied.
They were right behind us , We kept running then I noticed a weird hallway with red vines. It had a metal door with a panel.
We ran in and then I pushed a button on the panel which made the door close.
"We're safe for now huh" I exclaimed
"No......Look behind you" He said in a terrified voice.
I turned around and saw it. At the end of the hallway, The thing I barely escaped from last time was looking at us. Except it had grown 2 arms now , The flesh monster had arms and a huge red and black eye in the middle.
"Another unnatural huh" Tracey exclaimed.
"No......It's human" I replied.
"THAT THING IS A HUMAN?" Tracey said while looking at me with shock.
"Well it was , I'll explain later." I replied
"What is it supposed to be then?" He asked
"It's name is Dave , Spare the rest of the details for when we are out of her-"
Dave started charging towards us before I could finish my sentence.
"I'll take care of this" Tracey said before enlarging his left arm and throwing a punch towards it.
"NO-" I screamed
Too late , He had already punched it. It crashed behind me into a wall.
"What do you mean NO? We'd be dead if I didn't punch it" he exclaimed
"We need to get to the other side of the hallway NOW" I said as I started running
"Why are we running?" Tracey asked about halfway through.
"Just look back!" I exclaimed.
Dave was getting up on its feet , While it had 4 arms now instead of 2.
"WHY DOES IT HAVE 4 ARMS NOW?" Tracey screamed while running.
"It absorbs impact and grows , That's why I told u NOT TO PUNCH IT" I replied.
"A WARNING BEFOREHAND WILL BE APPRECIATED" he said to me furiously.
Dave started charging at us again , Faster than before. Tracey and I finally made it to the end of the hallway and through the door.
"I can't reach the button to close the door , It's too far away!" I cried out.
Tracey then stretched his left arm to hit the button. The doors closed just before Dave could make it in , He crashed into the door but wasn't able to break it.
"It should keep it out for sometime" I said while finally catching a breath.
"Now what is that?" Tracey asked in the same tone as when he saw Dave.
I turned around and realised that Tracey and I were not the only ones in the room.
submitted by No_Competition7327 to nosleep [link] [comments]


2024.05.16 10:25 MDDoctorTutors How to cheat on EXAMPLIFY Exam Take my Exam Exam Soft exams TEAS exam ATI Test Bank Download Exam Examplify Bypass ARMRIT exam questions HESI exam questions RN Comprehensive Predictor Exam ATI Comp Predictor HESI Exit Exam ATI RN Pharmacology ATI RN Medical Surgical Q bank

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2024.05.16 04:51 ThirdEyeGroovin [USA-NV][H] Chromebook, graphics cards, security equipment, Aiphones, Cameras, UPCs, and more 50%+ [W]Local prefered with discount or Paypal G/S

Hello, I just moved states and cleaned out the tech room of my old company. I have started to unpack boxes and have these items for sale so far. They are a mix of used and new. I took time to look them all up and post links in a document of the prices. I am doing 50-75% off pretty much all listed so just let me know! If you think a price is wrong let me know!
Timestamp and Items (Let me know about close ups(- https://imgur.com/a/j3Bk3je
Prices and links to product sheet- https://imgur.com/a/v2f9LN7
Local payment prefered and cheaper, but Paypal G/S accepted. Shipping depends on weight of item since they vary so much.
~Random~

· PDP Gaming LVL40 Wired Stereo Gaming Headset for Xbox Series X/S and Xbox One- $20 https://www.walmart.com/ip/Afterglow-LVL-40-Wired-Stereo-Gaming-Headset-for-Xbox-One-Gray/1666019256
· Skullcandy - Cassette Wireless On-Ear Headphones – Black- $31 https://www.bestbuy.com/site/skullcandy-cassette-wireless-on-ear-headphones-black/6411942.p?skuId=6411942&utm_source=feed
· Camera and Film- $150 new https://www.bestbuy.com/site/reviews/polaroid-originals-onestep-analog-instant-film-camera-white/6333622
~Computer Parts~
· Chromebook- $270 new https://www.newegg.com/samsung-chromebook-3-xe500c13-k04us/p/N82E16834132144
· Battery Backup- $190 new https://www.newegg.com/apc-bx1500m-5-x-nema-5-15r-5-x-nema-5-15p/N82E16842301561
· Asus GPU- $350 https://www.priceblaze.com/hd6670-2gd3.html
· PCI- IDK $20
· Microsemi PD-AS-951/12-24 12V-24V 60W High Power Splitter with DC Connector- $80 https://www.newegg.com/microsemi-pd-as-951-12-24-poe-splittep/N82E16833996072?item=N82E16833996072&nm_mc=knc-googleadwords&cm_mmc=knc-googleadwords-_-accessories%20-%20wired%20%26%20wireless-_-microsemi-_-33996072&utm_source=google&utm_medium=organic+shopping&utm_campaign=knc-googleadwords-_-accessories%20-%20wired%20%26%20wireless-_-microsemi-_-33996072&source=region
~Alarm Parts~
· Alarm DSC 1832 Board- $200 https://www.ebay.com/itm/144826916255
· DSC PCL-422 Communicator Remote Mounting Module 2017- $50 https://www.jmac.com/DSC_PCL_422_p/tyco-dsc-pcl-422.htm
· 2X DSC PC5108 8 Zone Expander- $80 https://www.jmac.com/DSC_PC5108FLR_p/TYCO-DSC-PC5108FLR.htm
· DSC PC4108 Zone Expander- $130 https://www.jmac.com/DSC_PC4108_p/tyco-dsc-pc4108.htm
· 3X DSC LCD4501 MAXSYS Programmable-Message LCD Keypad- $235 https://www.jmac.com/DSC_LCD_4501_p/TYCO-DSC-LCD-4501.htm?gad_source=1&gclid=CjwKCAjwupGyBhBBEiwA0UcqaNVgqdPmRKNEakRPDPTZzB43B-2be8misMiaOnVruxPFhGJDNTv0cxoC1EYQAvD_BwE
· 2X PK5500ENG Custom Alpha Keypad with English Function Keys- $250 https://www.worldeyecam.com/pk5500eng-custom-alpha-keypad-with-english-function-keys.html?srsltid=AfmBOopx2hPVcCLFrM4TqDnbkF5SPsNO60fDvF5tlATNcOI_rOoffw06tBw
· 2X DSC WT5500-433B Keypads(70009589)- $120 https://www.jmac.com/DSC_WT5500_p/TYCO-DSC-WT5500.htm
· DSC WT5500-433B Keypads(70009122)- $120 https://www.jmac.com/DSC_WT5500_p/TYCO-DSC-WT5500.htm
· DSC 3G8080 NEO. HSPA/CDMA Cellular Alarm Communicator- $90 https://www.ebay.com/itm/194963062897?chn=ps&mkevt=1&mkcid=28&srsltid=AfmBOoqDkfHSU-iTGSlGK5NNhU1TJWlm1WtRbzT-UkQYnnnQNdJhgFoROGQ
· 3X DSC Electronic Siren SD 15W- $15-20 https://www.amazon.com/DSC-SD-15W-ULF-15-Watt-Alarm-Siren/dp/B08VZ5JD8B
· 3X Alarm.com Image Sensor- $20- https://www.ebay.com/itm/225812964996?chn=ps&mkevt=1&mkcid=28&com_cvv=8fb3d522dc163aeadb66e08cd7450cbbdddc64c6cf2e8891f6d48747c6d56d2c
· DSC EV-DW4917 Wireless Recessed Door Transmitter- $70 https://www.jmac.com/DSC_EV_DW4917_p/TYCO-DSC-EV-DW4917.htm
~Aiphone Equipment~
· Aiphone JF-2HD JF Expanded Series Sub Monitor Station- $ 500 https://www.jmac.com/AiPhone_JF2HD_p/AIPHONE-JF-2HD.htm
· AiPhone JOW-2D- $110 https://www.jmac.com/AiPhone_JOW_2D_p/AIPHONE-JOW-2D.htm?gad_source=1&gclid=CjwKCAjwupGyBhBBEiwA0UcqaDcbJm7t1LVPXck2aziAY8U5bAFiL1IExlaXu77ZKwF51z-lAPEmaRoClFMQAvD_BwE
· AIPhone JF-DV Video Door Station- $270 https://www.jmac.com/AiPhone_JF_DV_p/AIPHONE-JF-DV.htm?gad_source=1&gclid=CjwKCAjwupGyBhBBEiwA0UcqaKIj4y5AK_KCIn0a5oBd6y5DdfN61lJ_1gWePqkZRN-SiyHlNuGHPBoCPfoQAvD_BwE
· 2X AiPhone RY-1824L- $35 https://www.jmac.com/AiPhone_RY_1824L_p/AIPHONE-RY-1824L.htm?gad_source=1&gclid=CjwKCAjwupGyBhBBEiwA0UcqaD3bOcsbBGBRaEVFXSBVGsdXIVXLHmiSJ0N9LhKO99zKq0Ou3jB4VRoC4Q4QAvD_BwE
· 2X AIPhone MCW-S/A Desktop Mount for Video Monitors- $30 https://www.jmac.com/AiPhone_MCW_SA_p/AIPHONE-MCW-S-A.htm
~Geovision Cameras/Card Access~
· 1X Geovision GV-RU9003 Outdoor UHF RFID Wiegand 64 Bit Long Range Reader- $640 https://allgeovision.com/index.php?route=product/product&product_id=13293
· 1X Geovision GV-RU9003 Outdoor UHF RFID Wiegand 64 Bit Long Range Reader(may not work and just be parts)- $640 https://allgeovision.com/index.php?route=product/product&product_id=13293
· 4X? Geovision GV-BL220D Used- $700 https://www.jmac.com/Geovision_BL220D_p/GEOVISION-BL220D.htm
· 2X Geovision GV-VD322D 3MP H.264 IR Vandal Proof IP Dome Camera Transparent Cover IK7 Used- $600 https://www.jmac.com/GeoVision_GV_VD320D_p/geovision-gv-vd320d.htm
· Geovision GV-EBL1100-1F Low Lux IP Bullet Camera, 1.3 MP, 6mm Lens- $250 https://www.jmac.com/GeoVision_84_EBL1100_1010_p/geovision-84-ebl1100-1010.htm
· GeoVision 120-EVD2100-000 2MP SUPER LOW LUX IR VANDALPROOF IP- $290 https://www.jmac.com/GeoVision_120_EVD2100_000_p/GEOVISION-120-EVD2100-000.htm=?HOP2
~Random Security Cameras~
· AXIS Q1755 60HZ- $1300 https://computingworlds.com/axis-0304-001-network-accessories.html?srsltid=AfmBOop64f-96bKDWDtdT-9bowOZ9FWtbOFcH31SpPqeIZ1BD6HPBR8mvhU
· IQeye IQD32S Security Camera- $150 https://www.refurbishedphones.com/products/19805/iqeye-iqd32s-security-camera


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2024.05.16 00:23 Ok-Description-6399 Guide-approach for complementary ketogenic regime and understand more

Complete remission of depression and anxiety using a ketogenic diet: case series

Front. Nutr., 14 May 2024 Sec. Clinical Nutrition Volume 11 - 2024 https://doi.org/10.3389/fnut.2024.1396685
Background: There is little data that describe the use of ketogenic metabolic therapy to achieve full remission of major depression and generalized anxiety disorder in clinical practice. We present a retrospective case series of three adults with major depression and generalized anxiety disorder with complex comorbidity, treated with personalized ketogenic metabolic therapy, who achieved complete remission of major depression and generalized anxiety disorder and improvements in flourishing, self-compassion, and metabolic health.
Methods: Three adults, ages 32–36, with major depression, generalized anxiety, other anxiety disorders, and comorbid psychiatric conditions were treated for 12–16 weeks with personalized whole food animal-based ketogenic metabolic therapy (1.5:1 ratio) in a specialized metabolic psychiatry practice. Interventions included twice-weekly visits with an experienced ketogenic registered dietitian; daily photo journaling and capillary blood BHB/glucose/GKI monitoring; virtual groups; family/friends support; nature walks and talks several times per week, and community building. Successful adoption of the ketogenic diet was defined as the achievement and maintenance of capillary BHB ≥ 0.8 mmol/L and GKI < 6. Remission was assessed by GAD-7 and PHQ-9, and quality of life was assessed subjectively and with validated scales for flourishing and self-compassion. Metabolic health was assessed by laboratories/biometric measures.
Results: Two patients achieved remission of major depression (PHQ-9 ≤ 4) and generalized anxiety (GAD-7 ≤ 4) within 7 weeks of therapeutic nutritional ketosis; one required 12 weeks. Anxiety responded and remitted more quickly than major depression. Flourishing and self-compassion increased steadily. Patients lost 10.9 to 14.8% of their initial body weight within 12 weeks and improved metabolically; one achieved optimal metabolic health.
Conclusion: Complete remission of major depression and generalized anxiety disorder occurred within 7–12 weeks of therapeutic nutritional ketosis during treatment with a personalized animal-based ketogenic diet (ratio 1.5:1) in adults with complex comorbid depression and anxiety engaged in a specialized metabolic psychiatry program.

Introduction

Emerging brain-based research in psychiatry and neurology has focused on identifying fundamental metabolic disturbances within neurons and throughout the body involving insulin resistance, inflammation, oxidative stress, and alterations of the gut microbiome (1). All four of these fundamental metabolic disturbances are present in major depression (2), and underlying anxiety disorders (3) and can be directly modulated through the use of ketogenic metabolic therapy (KMT) (4).
As psychiatric disorders have risen over the past several decades, the prevalence of metabolic syndrome has sharply increased, with only 12.2% of U.S. adults meeting the criteria for optimal metabolic health, leaving 87.8% metabolically compromised (5, 6).
Metabolic syndrome affects almost a third of individuals with major depression (7). It is a significant contributor to their morbidity and mortality (8) and is rooted in impaired glucose metabolism and utilization. Insulin resistance has been well described in many tissues, including the brain (9), where it is being investigated as a link between metabolic health and mental health conditions. Preclinical models demonstrate that glucose intolerance is directly associated with anxiety and that insulin resistance triggers depressive behaviors (9). In brain tissue, insulin resistance results in cerebral glucose hypometabolism and a vicious cycle of unmet energy needs (10). In human studies, cerebral glucose hypometabolism is a feature of major depression (11, 12) and generalized anxiety disorder (GAD) (13).
KMT, also known as the therapeutic ketogenic diet, or KD, is a low carbohydrate, moderate-protein, high-fat diet that supports a fundamental metabolic shift from glucose to ketone bodies as the primary fuel source (14). Classic KMTs are formulated with strict macronutrient ratios, most commonly 4:1 and 3:1 (fat: protein + carbohydrates), and have demonstrated efficacy in intractable epilepsy and genetic disorders. More recently, modified classic KMTs with lower macronutrient ratios of 2.5:1, 2:1, and 1.5:1 have been utilized in research and clinical practice (15, 16). These allow more variety in the diet, meet micronutrient needs except vitamin D (17), and are easier to sustain for extended periods of time.
KMT exploits the body’s natural ability to produce ketone bodies (d-beta-hydroxybutyrate (BHB), acetoacetate, and acetone) in the liver from fatty acids by keeping carbohydrate consumption very low. Acute and sustained production of ketone bodies produces a fundamental shift in fuel energetics within cells, particularly neurons, which can radically re-route and quickly rely on readily available BHB and acetoacetate for cellular energy (18). Ketone bodies also increase vascular density at the blood–brain barrier, which can strikingly increase the availability of ketone bodies for brain energy metabolism by 40-fold (19). Ketones are a preferred energy source in the CNS (20) and neurons will choose ketones over glucose when available.
Nutritional ketosis (10) using a KMT is a natural, not pathological, state (21) where the body’s energy and protein synthesis needs are met with a high-fat/moderate-protein/low-carbohydrate diet, resulting in sustained elevations of serum ketones and fatty acids and normal glucose without acidemia. In both acute and long-term nutritional ketosis, ketone bodies have a number of biological effects that directly change the brain’s cellular energy status (15), increase mitochondrial density (22), and improve mitochondrial morphology, which has been shown to be altered in mood disorders (23, 24). Mitochondrial abnormalities have also been postulated to be responsible for changes in synaptic function and neuroplasticity, potentially associated with symptoms of depression and anxiety (19).
Recent research shows that a ketogenic diet (KD) reduces neuronal firing rates, modulates ion channels and cell signaling cascades, and stimulates the biochemical synthesis and neurotransmission of GABA by inhibiting glutamate decarboxylase, a major inhibitory neurotransmitter involved in neuronal firing and anxiogenesis (25, 26). BHB activates the transcription of antioxidant-related genes by inhibiting histone deacetylases, triggering long-term adaptive changes in gene expression. In addition, at physiologic concentrations, ketone bodies reduce neuroinflammation through direct action at G-protein coupled receptors (25). KD also favorably alters the gut microbiome (27). Perhaps most importantly, KD directly increases NAD+, which reduces reactive oxygen species and increases mitochondrial ATP production. It is also utilized as a substrate for sirtuins and PARP enzymes associated with DNA repair and longevity. A sustained increase in NAD+ may underlie the pleiomorphic benefits of KMT across multiple neuropsychiatric conditions (28). In terms of the frequent abnormal alarms set off in the amygdala during anxiety, nutritional ketosis may provide an acute and long-term intervention to reduce generalized anxiety, panic attacks, obsessive doubt, and symptoms of post-traumatic stress disorder (PTSD). For apathy, anhedonia, amotivation, and abulia seen in major depression, therapeutic nutritional ketosis may provide higher and more sustained intraneuronal energy and repair (29, 30).
There is no published data that describes the implementation and use of personalized KMT for adults in real-world clinical practice who present with major depression comorbid with GAD and complex psychiatric comorbidity.
The aim of this case series is to examine the response to the treatment of major depression and generalized anxiety with whole-food animal-based personalized KMT in adults with complex psychiatric comorbidity and varied metabolic status. We conducted a retrospective review of three cases from our Metabolic Psychiatry Registry that demonstrate a consistent response and remission of major depression and generalized anxiety among patients who are psychiatrically and metabolically complex, despite differences in the initiation and adoption of KMT, and varied metabolic dysfunction. We describe the evaluation process and prescription of KMT, baseline metabolic workup and monitoring, elements that fostered treatment engagement and adherence, and challenges encountered during 12 weeks of KMT. We correlated capillary BHB/GKI with time to the remission of major depression and GAD and the achievement of metabolic health.

Discussion

Although KD was first shown to produce antidepressant effects and alleviate “behavioral despair” in preclinical studies more than 20 years ago (20), there is little clinical data regarding KD in major depression and anxiety disorders.
A retrospective analysis of 31 individuals with primary diagnoses of major depression (N = 7), bipolar II disorder (N = 13), and schizoaffective disorder (N = 12) who had failed to respond to conventional psychiatric care was treated with KD (75%–80% fat, 15%–20% protein, 5% carbohydrate) for 12 weeks in a psychiatric hospital (31). Of these patients, 22 were voluntarily admitted for the initiation of KD, and the remainder were offered KD during their inpatient hospital course. Change in depression was measured by HAM-D and MADRS in 6 of 7 patients with major depression and 12 of 13 patients with bipolar disorder. Notably, 100% of patients given the HAM-D showed statistically significant improvement in depressive symptoms (mean HAM-D decreased from 25.4 to 7.7; mean MADRS decreased from 29.6 to 10.1). However, serum ketones were not measured; urinary ketone measures were obtained once in 28 patients during the 12-week intervention; 18 patients (64%) showed positive urine ketones (31).
Bipolar depression was included in a recent randomized controlled pilot study assessing the safety and feasibility of KMT as adjunctive therapy, and reported safety and feasibility with excellent adherence and maintenance of ketosis (mean BHB 0.88 ± 0.99 mmol/L for 12 weeks) (32).
One case report utilized KD (65% fat, 25% protein, 10% carbs) with a time-restricted feeding window in a 65-year-old woman with major depression and type II diabetes and reported remission of depression (PHQ-9 17 to 0), normalization of HbA1c, decrease in estimated average glucose from 216 to 96 mg/dL, improvement in HOMA-IR from 9.4 to 2.3, and TG/HDL ratio from 4.7 to 1.2 over 12 weeks. The only measured serum BHB reported in the case was a mean of 1.5 mmol/L by week 12 (30).
A recent meta-analysis of low carbohydrate diets used in controlled trials that evaluated symptoms of depression and anxiety, not disorders, in varied metabolic and inflammatory conditions reported that the symptomatic response of these symptoms was inconclusive (33). The conclusions may not apply to KMTs; the meta-analysis was limited by grouping varied diets with higher carb intake and higher protein intake than usually associated with diets formulated to induce nutritional ketosis; serum or capillary BHB was not reported; and primary and secondary outcomes varied across studies.
In anxiety, preclinical research shows that exogenous ketone supplementation reduces anxiety behaviors (34). There is one case report of a self-administered Atkins Diet for weight loss in a woman with panic disorder (35) but no reports of KMT in panic disorder, OCD, or PTSD. Case reports of KD addressing anxiety describe two cases of decreased anxiety symptoms in a woman with women, one with bipolar I disorder and another with unspecified mood disorder, comorbid emotional dysregulation, body dysmorphic disorder, and eating disorder (36, 37), and one case report that describes the elimination of anxiety symptoms in a man with bipolar disorder (38). Anxiety and obsessive preoccupations improved in weight-restored anorexic women, in one case report describing complete remission of anorexia (39) and in a retrospective case series where animal-based KD was adopted without dietary prescription and monitoring (2); however, ketone measures were not reported. One small pilot trial where KD was followed by ketamine infusions reported a significant lessening of obsessive preoccupations in weight-recovered women with chronic anorexia; here, ketosis was measured by breath acetone (40).
Finally, all three patients had comorbid ADHD, which may be important. Approximately 65–89% of adults with ADHD experience one or more comorbid psychiatric conditions, and ADHD often occurs comorbid with anxiety and depression (41). Preclinical studies in murine models (42) of ADHD with hyperactivity suggest that KD may improve symptoms via alteration of the gut microbiome. Preclinical studies in dogs with epilepsy displaying ADHD-like behaviors treated with a medium-chain triglyceride KD have shown decreased pathological behaviors (43). Further research exploring the effect of KMT in humans with ADHD should be considered to understand the mechanisms of action and assess short- and long-term risks and benefits.
There is little research regarding the selection, implementation, and treatment course for KMT use as adjunctive or sole treatment in individual psychiatric conditions. Given the potential benefits of therapeutic nutritional ketosis and the restoration of metabolic health (44), there is a pressing need to identify the biological underpinnings of KD in psychiatric disorders and delineate factors associated with the successful adoption and adherence of KMT and responses in common psychiatric disorders such as depression and anxiety. In clinical practice and real-world settings, where patients often present with multiple comorbidities, consideration of KD can seem daunting to clinicians.
Despite that, this case series illustrates complete remission of both major depression and GAD in three adults with complex psychiatric comorbidity and previously unrecognized metabolic dysfunction using whole-food, animal-based personalized KMT. Anxiety responded first and time to remission occurred rapidly within 7–12 weeks, despite varied challenges, including preferences for time-restricted eating, slow adoption, inconsistent monitoring, and emergent fatigue during strenuous exercise, which occurred many weeks into KMT due to low serum carnitine and spontaneous reduction of protein intake rather than keto-adaptation or “keto-flu.” All patients improved metabolically, and one patient achieved optimal metabolic health (6).
These patients were representative of many adults in clinical psychiatric practice who present with persistent, serious symptoms interfering with several life domains. They each had five DSM-V psychiatric disorders: severe unipolar major depression, GAD, at least one other anxiety disorder (OCD, PTSD, and/or panic disorder), and ADHD, and two had binge eating disorder. They had all failed at least two previous adequate trials of medications and psychotherapy and were seeking relief. All had family histories of mood and anxiety disorders and documented metabolic disease in first-degree relatives. Extensive laboratory testing and bioimpedance evaluations were eye-opening because, although they were overweight, they were not aware of the extent to which they were already metabolically ill; we suspect it enhanced their motivation to adopt and maintain KMT.
This case series is limited by describing only three patients, which limits the generalizability of our results as well as the inherent selection bias, as they were interested in KMT after failing standard therapies. In addition, they were selected because their complex psychiatric comorbidity reflects the complexity seen in the majority of our outpatient psychiatric practice. This degree of complexity may limit the generalization of these findings, although it is important to note that outpatient clinical psychiatric practice as a whole has seen an increase in complex psychiatric comorbidity over the past two decades (44).
As a retrospective case series, there may be additional limiting and confounding factors, including the lack of a control group. Some rating scales and digital data are missing, which may impact the completeness of the analysis. Time to consistent nutritional ketosis and delays in obtaining necessary labs requiring intervention may have contributed to a longer time to response and remission; response and remission may occur earlier than reported here, and this deserves further research. Finally, it is not clear to what extent immersive treatment (see Supplementary material 1) and additional interventions during KMT, such as close digital monitoring, frequent clinical contact, group supports, and nature walks, contributed to the rapidity of response/remission of anxiety and depression, or to overall treatment success, independent of the biological effects of KMT, and which of these elements were most critical; more research is needed. Carefully designed prospective studies and randomized controlled trials providing higher levels of evidence are needed to examine the use of KMT and time to response and remission in individuals without comorbidity and determine the extent to which comorbidity may confound or alter these (8).
As metabolic psychiatry moves forward, we need both preclinical and larger, well-controlled clinical studies examining the pleiomorphic effects of ketone bodies in the brain and in the body to understand how we can best leverage whole foods to optimize brain energy, enhance genetic expression, reduce neuroinflammation, optimize metabolic health, and safeguard the promise of our future.
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2024.05.15 12:10 Strong_Tell499 U.S. Cellular is hiring Senior Data Warehouse Architect Chicago, IL US [Oracle Spark]

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2024.05.15 04:37 TrackingSystemDirect Best GPS Tracker For Long Distance & International Travel

Best GPS Tracker For Long Distance & International Travel

Best GPS Tracker For Long Distance & International Travel

As you embark on exciting adventures abroad, navigating unfamiliar territories and ensuring the safety of your belongings are crucial aspects of your journey. A GPS tracker that works internationally can be your perfect companion in this regard, providing a seamless travel experience. In this article, you'll discover the benefits of real-time GPS tracking when traveling abroad, and we'll reveal our top pick for the best personal GPS tracker for long distance!
Real Time GPS Tracker Works In 200+ Countries!
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Visit Website: https://konnectgps.com
  • Track A Vehicle In Nearly Any Country
  • Keep Your Personal Items Safe From Theft
  • Increase Personal Safety While Traveling Abroad
Already recognized as one of the top-performing car tracking units on the GPS market, the Konenct GPS tracking system has blown the competition away once again now that the tracker can operate in over 200 countries across the globe. This is the reason the personal GPS tracking device is ideal for international travel. On nearly a daily basis, the list of locations the live GPS tracker will work continues to grow. Initially viewed as a domestic GPS monitoring solution for consumers and businesses located in the United States, the engineers behind the device decided to make the unit more accessible to international clients after the boom in demand for live tracking devices. Today, people in Thailand, Canada, Bosnia, Australia, Saudi Arabia, Spain, Vietnam, Mexico, and other regions all across the planet are now able to take advantage of the tracker voted "Top Performing Live Tracking System" by GPS Tracking Review.

Benefits of Real-Time GPS Tracking When Traveling Abroad

Sharing Exact Location During Emergencies

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Traveling abroad has become increasingly popular among Americans, with a record 44.8 million U.S. citizensventuring overseas in 2019 alone. As you embark on your international journey, ensuring your safety and security becomes paramount. A GPS tracker for your vehicle or personal use can be a lifesaver in emergencies, allowing you to share your exact location with loved ones or local authorities. This not only ensures your safety but also provides invaluable peace of mind to those who care about you. Let us explain in a real-world scenario.
  • Emergency Lifesaver: In emergencies, the ability to share your exact location is not just convenient, it can be life-saving. Whether you find yourself lost, in danger, or in a medical emergency, a GPS tracker is your lifeline.
  • Real-Time Location Sharing: This technology allows you to send your precise location to loved ones or local authorities in real-time. This is important in letting them know where you are so they can find you, fast.
  • Real-World Scenario Value: Imagine you're driving through the scenic but remote roads of a foreign country and your vehicle breaks down. With no one in sight and perhaps a language barrier, your GPS tracker becomes your voice. It guides rescuers or local help directly to you, eliminating the guesswork and potential delays in getting assistance.
For instance, in 2017, a tourist named Sarah Wilson was trekking in the remote wilderness of New Zealand when she got lost. With the help of a personal GPS tracker with global coverage, she was able to send her coordinates to local authorities, who quickly came to her rescue. This incident highlights the importance of having a mini GPS tracker with an SOS button that sends out realtime alerts to predetermined contacts, making it even easier to get help when needed.

Location Sharing - Keeping Friends And Family Informed About Your Whereabouts

As you traverse through the vibrant streets of Barcelona or bask in the mesmerizing beauty of the Amalfi Coast, a car GPS tracker becomes an excellent way to keep your loved ones informed about your whereabouts. How? With you sharing your real time location with them 24/7. This GPS data can be accessed from a mobile phone or computer anytime. In fact, you can even program the GPS locator to alert loved ones every time you travel to a new city! This allows them to follow your journey and ensure you're safe and sound wherever your travels take you! Now, let's look at additional benefits of sharing your location while traveling.
  • Constant Connectivity: Imagine sharing your real-time location with your loved ones 24/7. They can see where you are at any moment, providing an unmatched peace of mind.
  • Easy Access: This GPS data isn't hidden away in some complex system. It's right there on their mobile phones or computers, accessible anytime, anywhere. They won't have to wonder where you are or if you're safe.
  • Automated Alerts: You can program your GPS locator to automatically notify your loved ones each time you arrive in a new city. This feature adds an exciting element for them as they virtually follow your journey, step by step.
  • Safety and Security: Your family and friends can ensure you're safe and sound, no matter where your travels take you. In the unlikely event of an emergency, they know exactly where to find you.
Remember, using a GPS tracker when traveling long distances isn't just about technology; it's about connecting with your loved ones in a meaningful way. It's about giving them a window into your world as you explore new horizons. So, as you wander through new landscapes and cities, let the GPS tracker be your silent guardian, invisibly weaving the bond of safety and connection with those you hold dear.

Lost Luggage Recovery - Protect Your Belongings When Traveling Internationally

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Lost luggage is an all-too-common problem for international travelers. In fact, it is estimated that millions of travel bags were reported missing globally in 2019. A mini GPS tracker, like the Invoxias Cellular GPS Tracker, can help you locate and recover lost bags with ease. Simply place the tracker inside your luggage, and you'll be able to track its location in realtime, ensuring your belongings are never too far from reach. Oh, and if you are traveling domestically, an Apple AirTag will probably get the job done!
  • Real-Time Location Tracking: Just slip this compact device into your luggage, and voila! You have real-time tracking at your fingertips. Whether your bag ends up in Berlin or Buenos Aires, you'll know exactly where it is.
  • Peace of Mind: The true value lies in the peace of mind it offers. No more anxiety over misplaced bags. Your belongings are always within virtual reach, ensuring that you can focus on enjoying your journey.
  • Quick Recovery: In the unfortunate event that your luggage does stray, recovery becomes a breeze. You’re not dependent on airline updates; you're in control, able to pinpoint your bag’s location and retrieve it swiftly.
  • Versatile for All Travel: And hey, if your adventures are closer to home, domestically speaking, an Apple AirTag might be all you need. It offers similar tracking capabilities, perfect for keeping tabs on your belongings during shorter trips.
A GPS tracker for long-distance travel allows you to never have to worry about misplaced or lost luggage when traveling abroad! It's not just about tracking; it's about reclaiming control over your travel experience, ensuring your focus remains on the joys of exploration, not the worries of what-ifs.

Geo-Fencing Alerts -Setting Virtual Boundaries For Added Safety Abroad

While the lure of foreign lands is undeniably enticing, it's important to stay vigilant, as dangers can lurk around every corner. In 2019, more than 1,300 U.S. citizens required consular assistance due to crimes abroad. Scary right? But the good news is you can protect yourself with the geo-fencing on a GPS locator. Let us explain. By setting virtual boundaries around specific locations like your hotel or a tourist attraction, your loved ones know the very second you are on the move. This can be very helpful if you are lost or in an unfamiliar location.

10 International Travel Safety Tips

  1. Research your destination and local customs before departing to ensure a safe and enjoyable trip.
  2. Invest in a reliable GPS tracker for vehicle safety, like the GL300 GPS Tracker or Vyncs GPS Tracker, for enhanced security.
  3. Keep important documents, such as passports and travel insurance, secure in a hidden location while exploring.
  4. Share your itinerary and location with friends and family using tracker devices and companion apps.
  5. Choose a GPS device with long-lasting battery life and easy installation for stress-free travel.
  6. Stay vigilant and be aware of your surroundings, particularly in unfamiliar locations.
  7. Avoid displaying expensive belongings or large amounts of cash to minimize the risk of theft.
  8. Use GPS trackers with antitheft alerts to safeguard your belongings and vehicle while abroad.
  9. Familiarize yourself with local emergency numbers and the locations of the nearest embassies or consulates.
  10. Respect local laws, guidelines, and culture to ensure a positive experience in the places you visit.

GPS Tracker For Long Distance - Frequently Asked Questions

Is a GPS Tracker Essential For International Travel Safety?

Yes, a GPS tracker significantly improves international travel safety. How? By allowing you to share your location with loved ones 24/7. This allows for faster assistance during emergencies.

Are There Subscription Fees For International GPS Tracking Devices?

Yes, many GPS tracking devices require a monthly subscription for their services. Subscription plans can include location updates, SIM card usage, and access to companion apps. Devices like the GeoZilla GPS and Brickhouse Security trackers often have different plans to choose from, allowing you to select the best option for your needs.

Can I Use My Fitness Tracker For Location Tracking While Traveling Abroad?

While fitness trackers can track your location to some extent, they're not specifically designed for international travel safety. A dedicated GPS tracker for your vehicle or personal use, such as the GL300 GPS Tracker or Vyncs GPS, provides more accurate and reliable location tracking, ensuring better safety during your journey. We also encourage you to look for a location tracking device with SOS pain button feature.

What Are Some Personal Safety Tips When Traveling Internationally?

To ensure personal safety during international travel, always stay vigilant and follow local guidelines. Keep your belongings secure with hidden tracking devices, like portable trackers or GPS trackers for cars. Communicate with loved ones using location-sharing features available on devices like the GeoZilla GPS. And most importantly, follow advice from credible sources like the U.S. Department of State for the most up-to-date information on your destination.
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2024.05.15 04:20 TrackingSystemDirect GPS Tracking Shipping Containers

GPS Tracking Shipping Containers

GPS Tracking For Shipping Containers: Preventing Cargo Theft

Are you concerned about the safety of your valuable cargo shipments in the face of the alarming rise in cargo theft? You're not the only one grappling with this challenge. Shockingly, the FBI reports that cargo theft amounts to nearly $30 billion annually in the United States alone. The question then arises: how can you safeguard your shipments effectively? The answer lies in the innovative use of GPS tracking for shipping containers.
This cutting-edge technology stands as a game-changer in the shipping industry, offering real-time, comprehensive tracking of your cargo. By reading this article, you will gain insights into how GPS tracking not only acts as a deterrent against theft but also significantly boosts operational efficiency. Get ready to explore the multifaceted advantages of GPS tracking and why it's becoming an indispensable tool for protecting your cargo shipments.
https://konnectgps.com/
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GPS Tracking For Shipping Containers - The Easy 5-Step Process

GPS tracking for shipping containers employs satellites to relay precise location data. Containers are equipped with GPS devices, constantly transmitting their whereabouts. This real-time monitoring is key for deterring theft and ensuring cargo safety. The system uses cellular and satellite networks for data transfer. Users access this information through secure online platforms. Instant alerts are sent for unexpected container movements. Geofencing technology establishes virtual perimeters for additional security. This setup also aids in optimizing routes, reducing delays, and improving delivery schedules. Essentially, GPS tracking is a comprehensive solution for safeguarding shipping containers.
  1. Device Setup and Activation. Install GPS devices on shipping containers and activate them for satellite communication.
  2. Continuous Tracking and Data Transmission. These devices continuously track container locations and transmit this data via cellular and satellite networks.
  3. Access and Monitoring. Users access real-time location data through a secure online platform, enabling constant monitoring of the containers.
  4. Alerts and Geofencing. Receive instant alerts for any unauthorized movement or geofence breaches, enhancing security measures.
  5. Route Optimization and Operational Improvement. Utilize GPS data for efficient route planning, reducing delays, and improving overall operational efficiency in shipping.

Best GPS Tracking Device For Shipping Containers

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The Oyster GPS tracking device is a location monitoring tool specifically designed for tracking shipping containers and valuable cargo assets. When considering this device over alternatives, especially those at a lower price point, it's important to assess its distinctive features and specifications.
Key Features:
  • Long Battery Life: Powered by three AA Energizer Ultimate Lithium batteries, offering up to five years of operation with one daily location update.
  • Versatile Tracking: Capable of updating location every five minutes when in motion and once a day when stationary.
  • Recovery Mode: Provides more frequent updates, useful for tracking in critical situations.
  • Instant Alerts: Sends notifications via text or email when cargo moves or enters/exits a geofenced area.
  • Wide Coverage: Supports 4G and 5G Cat-M1 Towers, ensuring connectivity in the US, Canada, and Mexico.
  • Rugged Design: Comes in a waterproof casing with an IP67 rating, making it suitable for harsh environmental conditions.
Specifications:
  • Size and Weight: Compact and lightweight, easy to install on various cargo assets.
  • Network Compatibility: Operates on both 4G and 5G networks for broader coverage.
  • Durability: Waterproof and dustproof with an IP67 rating.
When buying a GPS tracker or shipping containers, consider these features alongside your specific tracking needs, budget constraints, and the potential long-term benefits of investing in a reliable tracking solution. The price of the Oyster GPS tracking device, while potentially higher than some alternatives, reflects its extended battery life, robust build, and comprehensive coverage capabilities.

How Bad Is Cargo Theft - A Look Into The Stats

Navigating the world of cargo shipping involves understanding the risks associated with cargo theft. These quick facts shine a light on the extent of this problem, revealing what is most commonly stolen, where thefts tend to occur, and just how significant these losses can be. Get informed and stay ahead with these crucial statistics:
  • According to the FBI, the average value of goods stolen per cargo theft incident in the U.S. is approximately $214,000.
  • Food and beverages are the most targeted goods, accounting for nearly 20% of all cargo thefts.
  • Electronics make up the second most stolen goods, constituting around 15% of total cargo thefts.
  • The states most targeted for cargo theft are California, Texas, and Florida, which together account for over 60% of all reported incidents in the U.S.
  • Warehouses and truck stops are the most common places for cargo theft, with around 50% of thefts occurring at these locations.
  • Approximately $15-30 billion is lost annually in the U.S. due to cargo theft, according to the National Insurance Crime Bureau.
  • Less than 20% of stolen cargo is ever recovered, making prevention crucial in cargo management.
  • Thefts tend to spike around holidays, with notable increases around Thanksgiving and the 4th of July.
  • Global losses from cargo theft reached a staggering $22 billion in 2021, according to BSI's annual Global Supply Chain Intelligence report.

GPS Tracking Device For Shipments

Imagine how simple it becomes to monitor shipping containers and prevent cargo theft with GPS tracking devices. Picture this - you run a shipping business, and you want to keep a close eye on your containers. You attach a real-time GPS tracker to each container you wish to monitor.
This tracking system consistently beams back the container's location data. You can access this real-time GPS tracking data online, anytime you want. It's as if you're in constant communication with your cargo containers.
Every time one of your GPS-equipped containers moves, you receive a notification. Imagine the peace of mind this brings. Asset theft? That's a concern of the past.
Think about the precision and efficiency GPS tracking units add to your operations. You're able to calculate estimated delivery dates with a new level of accuracy.
But let's face it. Some criminals see cargo theft as a low-risk, high-reward endeavor. When a single container can contain a million-dollar payout in electronics or tobacco, the temptation for black market crooks is hard to ignore. Here are additional benefits of how real-time GPS tracking technology can be your solution for theft prevention and asset management:
  • Enhanced Asset Management: GPS asset trackers provide real-time location information for both powered and unpowered assets. This visibility enhances your ability to monitor specific containers and manage your fleet effectively.
  • Advanced Features: Incorporating technologies such as a Bluetooth gateway, temperature sensors, and IoT systems, these tracking devices offer more than just basic functions. They bring smart container capabilities, improving shipment tracking and ensuring the safety of the cargo.
  • User-Friendly Interface: With developer API and API integration, you can easily incorporate GPS tracking into your current operations. The tracking dashboard and container tracking software provide a user-friendly interface for quick access to data.
  • Adaptable to Increased Demand: As your business grows, these GPS container tracking solutions scale with your needs. They support additional features like trailer tracking, vehicle tracking, and chassis tracking to meet the increased demand in your operations
Learn more about trackers that work internationally!
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GPS Tracking Shipping Containers - Frequently Asked Questions

Do GPS Container Tracking Systems Work Anywhere In The World?

Yes, most GPS container tracking systems utilize a cellular network to transmit location data, ensuring global coverage. In some cases, the container GPS can record location data, but can't transmit it until the ship is in cellular coverage. However, it's essential to confirm that your specific tracking solution offers both global coverage and satellite tracking.

Can GPS Tracking Devices Help Reduce Costs In The Shipping Industry?

Absolutely! GPS tracking devices for shipping containers contribute to operational efficiency, enabling route optimization and better utilization of resources. This helps reduce costs associated with fuel consumption, insurance premiums, and asset recovery.

Are There Any IoT Sensors Available For Shipping Container Tracking?

Yes, IoT sensors are increasingly popular in the shipping industry. These sensors, such as temperature and humidity sensors, provide real-time environmental monitoring. Why is this important? Because it can help ensure cargo security and allow for better decision-making to protect sensitive goods!

How Can GPS Tracking Shipping Containers Improve Customer Experience?

With asset tracking systems, customers receive accurate information about the location and status of their shipments. This transparency allows them to make better-informed decisions and provides an enhanced customer experience with your service.

Can Container Tracking Technologies Offer More Than Just Location Tracking?

Definitely! Advanced container tracking technologies can provide valuable insights, such as dwell times and ETA predictions. This GPS data helps improve scheduling and overall efficiency in the shipping process!
Some photos in this article, "GPS Tracking Shipping Containers" were generated using AI
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2024.05.15 01:05 GPSTrackerShop1 California Department Of Fish And Wildlife GPS Trackers

 California Department Of Fish And Wildlife GPS Trackers

Department of Fish and Wildlife GPS Tracking

GPS Tracking Helps In Conservation
Visit website: https://spacehawkgps.com/products/best-hidden-gps-tracker-for-car
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  • Longest Battery Life Of Any GPS Tracker On The Market
  • Most Widely Used Live GPS Among Law Enforcement Agencies
  • Secretly Track Any Vehicle For $16.99 Per Month
LEARN MORE!
With more and more hipsters wanting to live a more "authentic" lifestyle, teens and millennials are walking away from the shopping malls and into nature. This is a great thing but it has caused some issues for conservation groups such as the California Department of Fish and Wildlife who spend their time fighting those who could cause damage to the natural environment. Whether it be people cultivating marijuana crops on protected land, issues related to species management, or maybe something as simple as people fishing without licenses, the California Department of Fish and Wildlife has a lot of work to do and unfortunately limited resources. However, technology is now helping fill in some of the gaps for the California Department of Fish and Wildlife who is calling upon GPS tracking devices for a number of different reasons.
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California Department of Fish and Wildlife Vehicles

One of the most obvious benefits of using GPS live tracking technology is how it can assist in vehicle management. The California Department of Fish and Wildlife are often lacking manpower and resources. Therefore, fewer people are available to cover a lot of land. That means efficiency is a high priority. When real-time auto tracking units are equipped on the California Department of Fish and Wildlife vehicles the process of documenting and managing vehicle activity becomes significantly easier. This is because live GPS systems provide up-to-date info about where a vehicle is located, speeds it is traveling, stops made, and more. Safe speed alerts can also be programmed. Other benefits from a fleet oversight perspective include:
1. Theft Security 2. Unlimited Historical Access 3. Safe Zone Alerts 4. Speed Alerts

Fighting Crime With GPS Tracking

Another benefit of using GPS monitoring systems among government agencies such as the Bureau of Land Management, Department of Homeland Security, or California Department of Fish and Wildlife is that the technology can also be pivotal in investigative work. Whether it be illegal poaching or the cultivation of illegal crops, bad things happen on public land all the time. These areas are often chosen as the setting for criminal activity because they are remote and often in regions where cellular service is not available. This means live GPS won't work. This is where data logging systems are proving their value and helping authorities conduct successful investigations.

GPS Data Logger For Government Employees

Passive GPS solutions record travel activity to the internal memory of the device. Information such as route traveled, speed-driven, and more are all recorded and stored on the car tracker. This data can then be reviewed once the tracker is removed from the target vehicle and downloaded. Here is a real-world example of how technology is employed successfully. The California Department of Fish and Wildlife received a top about a poacher illegally hunting mountain lions. The suspect is identified and shown to be frequenting areas where mountain lion populations are dwindling. The California Department of Fish and Wildlife acquires a warrant, puts a vehicle tracker on the car of the suspect, and then removes the GPS after a month. The data shows the suspect was indeed at the location where each mountain lion shooting took place. The California Department of Fish and Wildlife has its man and can move forward with an arrest.
The California Department of Fish and Wildlife has a tremendously challenging task and the work they do is for all of us. GPS monitoring systems are helping to make that job a little easier which is fantastic because when they do their job effectively it means they are preserving wildlife and essentially nature for everyone for generations to come.

Conservation Top Priority For U.S. Fish and Wildlife Service

Government Agency Calls Upon GPS
There are a number of government and federal agencies that serve a vital role to the public from everything to energy conservation to counter-terrorism, but there is only one agency that focuses solely on making certain the next generation of wildlife is secure and safe. The U.S. Fish and Wildlife Service works tirelessly to conserve and safeguard fish, wildlife, plants, and their natural habitats through scientific experimentation and the creation of refuges. All of the work is conducted by professionals who strive to protect natural resources. However, the task of maintaining stable ecosystems and the life they support can be a very daunting task, and that is why the U.S. Fish and Wildlife Service continues to call upon the latest in technological advancement to help in conservation efforts. With many government agencies feeling the financial pinch, departments such as the U.S. Fish and Wildlife Service are now turning to GPS tracking systems to help conduct business as usual, and what they are finding is that GPS tracking devices are not only a cost-smart solution for monitoring equipment/environment but also an effective one.
GPS tracking systems have always been the surveillance tools of choice among federal police agencies to conduct covert investigations, but now the monitoring technology has taken on increased responsibility. Now, GPS monitoring technology and devices are used for everything from GPS fleet management improvement to the observation of wildlife in scientific experiments and studies. There are still many mysteries that ecologists and wildlife experts are trying to solve regarding the way many animals interact with their natural environment and the role that humans play in disrupting that balance. By equipping different species with micro GPS trackers that can transmit real-time GPS tracking and location-based data, scientists can understand how a particular species interact with everything in their environment.
With many staff members working for the U.S. Fish and Wildlife Service having to conduct experiments in the field, vehicle management and route efficiency are also a concern for the federal agency. However, real-time GPS tracking solutions such as SpaceHawk GPS can bring simplicity to a complex fleet problem. The SpaceHawk GPS allows government agencies to remotely view where any agency vehicle is while operating in the field. This GPS data can be used for fuel consumption reduction, a way to observe employee activity via vehicle tracking, and/or see what areas in a region a particular employee/scientist visited for experimentation.
Tracking System Direct would like to thank those working for the U.S. Fish and Wildlife Service for their conservation efforts and focus on maintaining and preserving our most precious resources.
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