Treatment for weeping ulcer
Painful leg ulcer - tips, oxygen therapy, hyperbaric chamber, anything?
2024.05.17 00:06 Remote_Sleep_9352 Painful leg ulcer - tips, oxygen therapy, hyperbaric chamber, anything?
Hello my father (70) has a bad ulcer on his leg that has not healed in 3 yrs. He has a history of them, and DVT. It's extremely painful and no pain medication has helped. He's also on warfarin so can't take most of what's on offer unfortunately. So it's mostly paracetamol..
He has been lucky enough to have access to a hyperbaric chamber. He went for a month and the doctor says he sees a small improvement. He is taking a break and then will continue.
I'm curious if anyone else has tried this?
Or generally any treatments or therapies?
It breaks my heart to see him in so much pain and suffering. I feel so helpless. He also needs a hip operation and can barely walk, but cannot do that until the ulcer heals.
Thanks in advance, and sending you all good and healing energy đ
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2024.05.16 23:12 KyleKKent OOCS, Into A Wider Galaxy, Part 005
~First~ A Scion of Many Worlds
Observer Wu was not sure about this next call. There had been rumours, rumours stories and absurdities from first to last. But this was one he would need to investigate thoroughly. He steels his face to a neutral position as the call goes through.
âYouâre on a drone observing. I am working.â Is the first thing that comes through. A voice simultaneously deep but accompanied with a chorus of tingling bells. The image shows an enormous figure that appears to be primarily composed of shimmering white fur looking over the 3D model of a building as he directs things through the air with his right hand. Support structures, beams and building materials all soar at his direction and quickly slam themselves into place to quickly construct a large structure. âI am capable of speaking as I work, so if you have questions then ask them.â
âI am Observer Wu from Earth. I am looking for Mister Blue.
âI am one of the Blues.â The enormous figure states. âJasper Blue, also Emmanuel Skitterway.â
The camera zooms in before something white catches onto it and itâs forced back. âApologies, the drone is not of the best quality.â
âI would assume that a... God Emperor would have better?â
âI am directing these resources into infrastructure. Things like this sewage processing plant will not build themselves and the components that the camera drone requires are better spent ensuring that pathogens are kept out of the water, or that a medical scanner has appropriate redundancies.â Emmanuel replies as the panelling to the outside of the building start attaching itself at his direction and theyâre quickly left with a solid looking structure with numerous tanks to the side.
âAlright the building is finished! Painters! Have your way with it!â He calls out and numerous people rush up with decorating supplies. âThere is more for me to do. While many of the relief ships arrived with prefabricated buildings there was an unfortunate and nearly universal blindspot in their considerations.â
âWhich is?â
âThat while the world is settled by many respects, it was at a late iron age level at best, borderline tribal in other areas. Sewage treatment and sanitation concerns like that are simply not in their proper place. Every major and minor settlement requires a massive overhaul of itâs infrastructure in order to bring the living standards up to even industrial levels, let alone galactic levels.â Emmanuel states.
âThis seems rather menial for someone ostensibly in charge of an entire planet.â
âDelegation. I have any communications and status updates relayed to me through that pursuing drone, itâs a handâs free system, so while it is not always at one hundred percent satisfaction it allows me to lead while I also work. After all, many of the legislative concerns can be easily taken care of by my numerous assistants, but only a handful of people have the sanitation know how and willingness to work and put together sewage containment.â
âA little demeaning for one worshipped as a god.â
âI am a Primal. Iâm going to be regarded as such whether I indent a throne with an ever widening rear or gunk out sewer lines, and of the two only one of them actually makes things better.â Emmanuel dismisses.
âReally. Yet youâre still not getting dirty.â
âI could do things less efficiently to look like Iâve been working hard, but honestly itâs all in the Axiom. The truth of the matter is that sewer work with even just a small amount of technology is more boring than dirty.â Emmanuel states before turning, the camera turns with him. It now shows where an entire army of workers are installing the pipes and systems for a proper sewage network. âStill, not bad eh? One year ago this place was an abandoned wreck of a smaller city. The population all but mind controlled by a group of religious fanatics who convinced them to abandon their homes and any dignity. Theyâve come a long way since.â Emmanuel states.
âHave they?â
âThis was the Greenstone Alliance Territory, a breakaway state from The Empire of Miru. To them the cannon was the military innovation rocking the nation.â
âI see...â
âNow they get air conditioning, indoor plumbing, heating in the winter, canned food for the leaner months, telephones to speak with their loved ones over a distance, radio for alerts and entertainment and far more.â Emmanuel states as he indicates an antenna being set up.
âAll that?â Observer Wu remarks. âYou seem a little... involved for a supposed god.â
âThere are two so called gods on this world.â Emmanuel replies. âI, who have personally conquered much of it, wheeled and dealed with other nations and proved myself as warrior and leader both, and Yserizan. Yserizan is either the mother, grandmother or great grandmother of at least a quarter of the world population.â
âAnd your relationship to this Yserizan?â
âOne of my wives. Our union was also a unification of Lablan as a single strong point on this world and...â
âWhatâs this?â A new voice asks and the camera reorients to a young woman with glowing golden hair.
âJust a camera drone, nothing to be concerned about.â Emmanuel states.
âOh. So itâs watching us?â
âYes.â
âAnd the image of the person on top of it?â
âThe person watching.â
âWho is he?â
âObserver Wu.â
âAnd why is an Observer needed?â
âDo you recall whenever Earth or the Origins of Humanity are discussed?â
âA little? Every time I seem to get a little bit more education it just lets me see how much more there is.â
âOh thatâs very normal.â Emmanuel replies.
âIf I may be introduced?â Observer Wu asks.
âI am Empress Zaviah Enlightened Luxen Divine Ascendant, ruler of Miru Reborn.â
âMiru Reborn is?â
âOne of the largest empires upon Lakran. Consisting of Central Miru, The Greenstone Territories of Northern Miru and The Goldlands Unification of Southern Miru. Our population is primarily Erumenta of all types, but other peoples are of course welcome.â
âAnd what brought about this rebirth?â Observer Wu asks and his eyebrows go up as Zaviah points right at Emmanuel.
âHeh, guilty. Everywhere I turned the planet seemed to just be full of more and more problems that needed to stop sometime ten years ago and no one else was available. So I did the best I could.â
âAnd then broke armies, nations and all known limits upon people.â
âAll presently known limits, what I did is only impressive when itâs weighed in that I started with only Horaceâs memories and didnât even understand how an Urthani body fully worked at the time.â Emmanuel states.
âYes. I read that report. It was absurd.â
âIt was accurate. We have all the parties involved to attest for it here on planet if you care to speak with them.â Emmanuel notes as he checks a device and nods. âAll right, next is...â
âBreak.â Zaviah tells him.
âExcuse me.â
âGrandmother has given ME the authority to force you into rest father!â Zaviah says with relish in her tone.
âShe wouldnât!â
âShe has! If I see that youâre working too hard I can tell you to stop.â
âYou do know she legally has no such authority over me right?â Emmanuel asks pointing a diamond plated claw at the comparatively tiny Erumenta whoâs grinning widely at this.
âYes, but sheâll be so disappointed that her little boy isnât taking care of himself anymore even though he promised to and...â
âIt was a mistake working so hard to make the two of you friends.â Emmanuel says in a note of false despair. âJust a moment Iâll instruct the work crew on the next few communities to proceed without me.â
âThat sounds like work.â
âA text to go with Plan B rather than Plan A is not work, itâs good manners.â Emmanuel protests and raises an eye ridge as a much smaller girl tries to glare him down. âAre you sure you want to put so much force into your day by day interactions while...â
A tiny dark shape slams into Zaviah to the Erumentaâs audible protest as Magrica starts gushing about how cute it is for the little girl to finally have some grit in her gut and how sheâs going to braid her hair and take her monster hunting and get her a battleaxe to go with that attitude...
Emmanuel turns to the politely puzzled Wu and shrugs.
âMotherhood does amazing things to some women. Magrica was much more openly fierce before, but she decided that all my children, adopted and otherwise, were hers to teach and nurture into proper warriors.â
âAnd how did she take the fact that you are technically the step parent of a quarter of the worldâs population if what you told me about Yserizan is correct?â
âShe has an entire squadron of Nagasha sheâs training to be monster hunters. Itâs actually going pretty well. The Jungle Nagasha are really appreciating it more than the other types, but the few Cloud Nagasha they have as scouts and aerial reconnaissance are fully embracing the role.â
âAnd how are you taking to... godhood?â Observer Wu asks his eyes penetrating.
âIt grows more comfortable unfortunately.â
âUnfortunately.â Wu repeats. Not questioning, but certainly prompting.
âIâve had to put aside my own prejudices in the matter. Humans have a bad track record with self proclaimed gods and messiahs. Too many fakes and too many holy wars. To say nothing of the cults, witch-hunts and the like. And Urthani would follow any number of faiths, but the divine figure was either some kind of Divine Truth, a more abstract theology, gods that embody concepts or something animist for the most part.â
âDid you look to The Nagasha for a better example?â
âI did, and thatâs what caused me to grow more comfortable with the title. Primal Nagasha arenât worshipped in the way humans would a prohet or saint. Seeing them as nigh infallible. No, a Primal Nagasha is simply the very best that a Nagasha can be and it can neither be stopped nor denied. While most of them are indeed leaders to follow, authorities to obey or the sources of philosophy to accept, they are not regarded as unquestionable or infallible.â
âAnd that is what helped?â
âIt is. I was terrified that someone would misinterpret me, either honestly or malevolently, and cause immense damage in my name. A crusade to cull any politician that isnât in the military through fire and steel, or an Urthani Colony deciding that they deserve the entire world and since not only have the strength now, but a god of their own, that they are righteous in slaughter... I had several kinds of nightmare when I let my mind wander.â
âAnd?â Wu prompts.
âI had a conversation. An important one with an important person. She helped me put everything in perspective. But sheâs not the type to appreciate too much attention. So sheâs requested I keep things quiet. But, I can say that she is an authority on the subject. And she had a fair amount to say.â
âSo youâve spoken to other so called gods of the serpent people.â
âPrimal Nagasha, and yes. One has arrived already, she lives her life as quietly as she can. Another is soon to arrive. The first wanted my measure, the second wants to ensure that as a more militaristic Primal that Iâm up to standard as she calls it.â
âOh?â
âIâm part of the smallest stable demographic in the galaxy. Primals. Apparently weâre a very self policing people.â
âSo in other words, youâre more a celebrity in multiple fields than some object of worship?â
âCloser to actual worship than celebrity worship Iâm afraid. Still, itâs not mindless, and those that are looking for an excuse... well theyâll find another one if itâs not me. At least if someoneâs trying to use my name to do something horrible it means I have all moral authority to let them know how stupid such a thing is.â
âI suppose that is an upside to an insane cult deciding that it wants to go on a rampage in your name.â
âBut thatâs just the thing I really had to internalize, if theyâre going to do that, then theyâre going to do it and Iâm just their excuse. Theyâll find another if Iâm not available. Iâm responsible for the example I set, the actions I do and the things I say. I am not responsible for how they are interpreted.â
âInteresting. Still, is there a reason youâre sharing this in particular?â
âI figured the most distressing thing that Earth would consider about my situation was my rise into divine stature. A powerful soldier can be understood, a powerful politician or businessman can also be understood, but someone being regarded as a god can not be understood within a positive context thanks to the rather terrible history of such on Earth.â Emmanuel says.
âThat... is an interesting concern. However, you do not think your conquering an entire world to be a bad thing?â
âConsidering that it was basically in unending war, competition and self sabotage? Yes. You see, this world was suffering over an unending brain drain due to the fact that all male colonists were lost in the initial crash of the colony ship. There were surviving males, but they were in stasis and could not be retrieved. The method that was used to ensure there would be a future population was flawed, intended as an emergency stopgap. But they didnât have the means to move past it. So it was used over and over again. This world was nearing the breaking point.â
âAnd that justifies conquering it?â
âWhen the nation states are tearing themselves apart through mindless pride? Scheming for the sake of scheming? Or are outright predating the other states? Yes, yes it does. To not intervene would have killed, far, far more people.â
âSo you justify things by saying that thye will thank you some day?â
âThey thank me now.â
âAnd itâs sincere?â
âYes, considering that Iâve had a woman weep with relief at getting something as simple as a pair of glasses, or another outright beg for her child and herself to be healed of the degeneration theyâve suffered. How can I consider it anything but sincere?â Emmanuel asks.
âOh? Who are you speaking with?â A new voice asks before a massive serpent woman slithers into Wuâs field of view. Her hood is fully flared out to reveal her as Lady Yserizan as she regards things. âA human friend?â
âAn Observer from earth, theyâre struggling to believe all the things theyâve been told.â
âConsidering some mornings I wake up scarcely believing how my life has changed for the better I donât blame them.â Yserizan notes happily. âStill, is there anything this... Observer wants to know in particular?â
âIn particular I want to know many things. Iâm just saying my first hello and listening to whatever anyone wants to say to me. Iâll be visiting that world before I return to Earth so make of that what you will.â Observer Wu says.
âOf course, it might be interesting to show you the temple my daughters made for me.â
âI will admit, receiving a tour of a living godâs temple from the god themselves will be a new experience for me.â Observer Wu admits.
~First~ Last submitted by
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2024.05.16 20:29 Andrea_Anastasia12 Water weight/hospital stays
This is personal experience and I wanted to use it as an example. I have an ulcer I went in for treatment to take care of yesterday, and a few days before that I was in the ER. I was 169.2# yesterday before I went into hospital and 177.1# today when I weighed myself after I got home. ALL OF THAT IS FLUID/WATER! insanity!! I hope đ€đ» pee it out soon đ€Ł
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2024.05.16 20:18 smirse Celiac disease, wheat allergy, gluten sensitivity: what are the differences according to a gastroenterologist?
Wheat is the basis of our diet. World Celiac Day, May 16, is an opportunity to take stock of its involvement in several pathologies. Wheat allergy, gluten sensitivity or intolerance, how to navigate it? A gastroenterologist helps us see things more clearly.
Celiac disease (gluten intolerance)
Its causes This autoimmune disease specifically linked to gluten (notably
gliadin ) occurs in a
genetically predisposed area . We also talk about gluten intolerance.
Its symptoms
Celiac disease can
begin at any age, including in the elderly (20% of people affected are over 60 years old) and affects women more frequently than men.
The diagnostic assessment is less and less often carried out (less than 20% of cases) in the face of classic manifestations: weight loss, bloating, diarrhea, deficiencies, etc. It is most often carried out in the face of non-specific digestive symptoms, symptoms extra digestive (sterility, alopecia, early or severe osteoporosis, recurrent mouth ulcers), or even biological abnormalities (iron deficiency anemia, liver problems, etc.).
The treatment
Strict exclusion of gluten (wheat, spelled, wheat, kamut, rye, barley) for life.
Oatsare tolerated if they are certified gluten-free .
Wheat allergyWheat allergy
Its causesIts causes Different proteins contained in wheat can cause an allergy: albumins, globulins and gliadins and glutenins (gluten proteins).
Its symptomsIts symptoms In infants, it can manifest in a chronic form, such as enteropathy, with symptoms similar to those of celiac disease: weight loss, abdominal pain, bloating. ..
In children, various symptoms occur within 2 to 4 hours after ingestion, often within the first year of life. They are similar to those of a classic food allergy : burning and itching in the mouth, rhinoconjunctivitis, eczema, skin rashes, abdominal pain, vomiting, diarrhea, and even in severe forms anaphylactic shock.
In adolescents and adults, wheat allergy generally takes a particular form which results in symptoms which only appear when the ingestion of wheat is associated with rather intense physical effort, or after taking alcohol or anti-inflammatories. They are varied: digestive disorders, generalized urticaria, difficulty breathing, even anaphylactic shock.
The treatmentThe treatment In children: elimination of wheat, rye, barley and oats. After the age of 16, 96% of adolescents become tolerant and recover.
In the case of exercise-related allergy: no consumption of wheat in the 4 to 5 hours before or after significant physical exercise.
Non-celiac wheat sensitivity (gluten sensitivity)Non-celiac wheat sensitivity (gluten sensitivity)
Its causesIts causes It has
no clearly defined basis at the moment. The following are implicated: gluten, ATIs (amylase/trypsin inhibitors) and fructans (which are fermentable carbohydrates falling into the category of FODMAPs.
The diagnosis is only made after elimination of wheat allergy and celiac disease.
Its symptomsIts symptoms Sensitivity to wheat combines:
- digestive signs :abdominal pain, diarrhea, bloating, etc.,
- extradigestive signs :significant fatigue, particularly after a meal, joint and sometimes muscle pain, skin rash (eczema, etc.).
The treatmentThe treatment After the elimination of celiac disease and wheat allergy (essential condition), start with a strict gluten-free diet (wheat, rye, barley, oats) for 6 weeks, to confirm the diagnosis in case of disappearance of symptoms.
Then, reintroduction, starting with foods containing traces of gluten and, depending on tolerance, with very gradually increasing quantities, each person having to find their tolerance threshold.
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2024.05.16 19:32 smirse Celiac disease, wheat allergy, gluten sensitivity: what are the differences according to a gastroenterologist?
Wheat is the basis of our diet. World Celiac Day, May 16, is an opportunity to take stock of its involvement in several pathologies. Wheat allergy, gluten sensitivity or intolerance, how to navigate it? A gastroenterologist helps us see things more clearly.
Celiac disease (gluten intolerance)
Its causes This autoimmune disease specifically linked to gluten (notably
gliadin ) occurs in a
genetically predisposed area . We also talk about gluten intolerance.
Its symptoms
Celiac disease can
begin at any age, including in the elderly (20% of people affected are over 60 years old) and affects women more frequently than men.
The diagnostic assessment is less and less often carried out (less than 20% of cases) in the face of classic manifestations: weight loss, bloating, diarrhea, deficiencies, etc. It is most often carried out in the face of non-specific digestive symptoms, symptoms extra digestive (sterility, alopecia, early or severe osteoporosis, recurrent mouth ulcers), or even biological abnormalities (iron deficiency anemia, liver problems, etc.).
The treatment
Strict exclusion of gluten (wheat, spelled, wheat, kamut, rye, barley) for life.
Oatsare tolerated if they are certified gluten-free .
Wheat allergyWheat allergy
Its causesIts causes Different proteins contained in wheat can cause an allergy: albumins, globulins and gliadins and glutenins (gluten proteins).
Its symptomsIts symptoms In infants, it can manifest in a chronic form, such as enteropathy, with symptoms similar to those of celiac disease: weight loss, abdominal pain, bloating. ..
In children, various symptoms occur within 2 to 4 hours after ingestion, often within the first year of life. They are similar to those of a classic food allergy : burning and itching in the mouth, rhinoconjunctivitis, eczema, skin rashes, abdominal pain, vomiting, diarrhea, and even in severe forms anaphylactic shock.
In adolescents and adults, wheat allergy generally takes a particular form which results in symptoms which only appear when the ingestion of wheat is associated with rather intense physical effort, or after taking alcohol or anti-inflammatories. They are varied: digestive disorders, generalized urticaria, difficulty breathing, even anaphylactic shock.
The treatmentThe treatment In children: elimination of wheat, rye, barley and oats. After the age of 16, 96% of adolescents become tolerant and recover.
In the case of exercise-related allergy: no consumption of wheat in the 4 to 5 hours before or after significant physical exercise.
Non-celiac wheat sensitivity (gluten sensitivity)Non-celiac wheat sensitivity (gluten sensitivity)
Its causesIts causes It has
no clearly defined basis at the moment. The following are implicated: gluten, ATIs (amylase/trypsin inhibitors) and fructans (which are fermentable carbohydrates falling into the category of FODMAPs.
The diagnosis is only made after elimination of wheat allergy and celiac disease.
Its symptomsIts symptoms Sensitivity to wheat combines:
- digestive signs :abdominal pain, diarrhea, bloating, etc.,
- extradigestive signs :significant fatigue, particularly after a meal, joint and sometimes muscle pain, skin rash (eczema, etc.).
The treatmentThe treatment After the elimination of celiac disease and wheat allergy (essential condition), start with a strict gluten-free diet (wheat, rye, barley, oats) for 6 weeks, to confirm the diagnosis in case of disappearance of symptoms.
Then, reintroduction, starting with foods containing traces of gluten and, depending on tolerance, with very gradually increasing quantities, each person having to find their tolerance threshold.
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2024.05.16 17:23 CocoaPuffs77 Need help making a decision for my health
Hi, this is probably my last post here. I posted here a couples times during the last week because I am at a complete lost.
Here is my story. When I was first diagnosed with ulcerative colitis it was only at the very end of the colon and only 10cm long. I went on budesonide (for 3months) and then mesalamine. It worked well for around 2 years, I had no symptoms (apart from cramps and bloating from time to time but my doctor said it could be IBS symptoms) and could eat whatever I want.. Lately I had alot of stress and went into a bad flare, did a sigmoidoscopy and the doctor said it was definitely worst and progressing. He wants to put me on budesonide (for 3months) and mercaptopurine (forever). I started budesonide but I am really scared of mercaptopurine and I really want to stay on mesalamineâŠ
I tried to make another appointment with the doctor but he was fully booked so I asked the secretary to ask him what were the risks of just staying on mesalamine after the budesonide course to see if it will work again. She called me back and said that the doctor said that budesonide and mercaptopurine was his recommendation and that I can do whatever I want but staying on mesalamine is going against his recommendation. He said that if I was not happy with his recommendation I could go get a second opinion. But where I live it takes 2years to see a specialist so that is really not an option. I talked to him during my last appointment about going on entyvio because its safer but in Canada he says we cant unless we try alot of other options before. I insisted but he says he really cant. I didnât think of asking him for other options then mercaptopurine or entyvio.
Now I canât see him again. Canât see another doctor either. Deadly scared of starting mercaptopurine but also scared of what can happen if I try mesalamine again and it fails.. will I get much worse and have to have more aggresive treatment⊠my plan would be to just give mesalamine another chance (since it worked well for 2years, its already going better with budesonide and I was under alot of stress when I had a flare) and if it gets worse, or not better in a couple months, restart budesonide and get on mercaptopurine. But since he said it was against his medical advice (and I canât talk to him to know exactly why and the risks) im scared.
I donât know if some of you were in similar situation and has some advice.
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2024.05.16 16:53 Connect-Heron-401 Calendula officialis
| Habitat and cultivation Calendula officinalis is native to southern Europe and is widely cultivated in temperate regions around the world. Extremely easy for seed propagation and suitable for almost all types of soil. Harvest the flowers in early summer and dry them in the shade. Main functions Anti-inflammatory Relieve muscle spasms An astringent Stop the bleeding Heal the wound Antibacterial Detoxify Estrogenic effect Practical application Calendula has an antibacterial effect, killing bacteria or viruses. Some ingredients (especially the resin) are antifungal and are significantly resistant to Candida albicans. It also has the function of contracting capillaries. Skin Treatment Calendula is preferred for the treatment of skin diseases and is effective for most mild skin problems. It can treat skin conditions such as cuts, scrapes, red and swollen skin (including mild burns and sunburns), acne or rashes, and it can also treat fungal skin infections, including ringworm, athlete's foot and thrush. In addition, it is also very effective for diaper rash and cradle cap, which can relieve the pain of nipple ulcers caused by breast-feeding. Indigestion Infusions and tinctures of Calendula officinalis are used internally to treat digestive system inflammation, such as gastritis, gastric ulcers, Crohn's disease, and colitis. Detoxification Calendula has long been used as a detoxifying herb to deal with toxins caused by fever, infection or systemic skin diseases, including eczema and acne. It can also purify the liver and gallbladder and treat diseases related to these organs. Gynecological use Calendula officinalis has a mild estrogenic effect and is often used to relieve pain. submitted by Connect-Heron-401 to u/Connect-Heron-401 [link] [comments] |
2024.05.16 16:26 ChannelAb3 How I Wonder What You Are by Al Bruno III
Iâll know the time is right when the howling begins. It will be after sundown of course, the Mothers and Fathers of Jebsen only scream after sundown, and only on the clearest of nights.
There is no town of Jebsen listed on any map, even in its heyday of the 1940âs it was too small to be worthy of notice. Itâs nothing more than a collection of buildings at the end of a dead end road. On one side it is bordered by long untended corn fields, on the other the swampy remains of Lake Campbell. The most noticeable of the townâs buildings is a red brick edifice with a wide domed roof of fractured glass. The rest is just barns and single story homes. Along the border of the swamp is row after row of barbed wire and bear traps.
Iâll let them scream for an hour or so, let them become tired. Even now it amazes me how I had learned to pick out the individual voices in the cacophony. The Widow Toth tires easily but the Garrets will be at it until dawn.
And what will I be doing while every able-bodied adult is on the rooftops? Iâll be slipping these pages into this mason jar and sealing it lid in place with the wax from a melted crayon. The Children of Jebsen wonât miss just one, especially not purple.
Twenty-five years ago a calamity befell the town of Jebsen. The authorities blamed it all on the after effects of an experimental insecticide but the Old Book the town elders read from every Sunday said otherwise. It told the citizens of Jebsen that a curse was carried by those twinkling dots in the sky. A malevolence traveling at 186,000 miles per second that would twist their Children into nightmares should a glint of it ever touch their skin.
That is why they scream at the starlight; hating it, cursing it, raging at it.
You canât see what their Children have become and not feel the same way. The changes are heartbreaking and horrifying all at once but after you spend time with them you feel differently. There is mockery in the mis-set eyes that peer from those mollified skulls.
They know secrets. On quiet, cloudy nights I would put my ear to one familiesâ basement door or another and hear them murmuring and giggling as they writhe in their basement styes.
I think of their weeping mouths and soft teeth and remember that day half a decade ago the ill-advised shortcut and along the neglected county route 99. I remember approaching the train bridge and seriously considering turning around, it looked decades out of repair and I half suspected it would collapse as I passed under it.
But I didnât turn back, my ego wouldnât let me. I was right and the road was wrong so I drove under the train bridge, momentarily marveling at the strange and elaborate graffiti that covered it.
I was just past the structure when a small, bent figure ran out from the long grass.
The sounds are what I really remember; the squeal of the brakes, the thud of the body on the hood of my car, the thick crack of laminated glass.
I would later learn the name of the child I had hit was Julius McCarty but all I knew then was that there was an emaciated, bloodied shape lying halfway through my windshield.
Human instinct made me reach out, to see if the little boy was alive. When my fingers brushed his skin he twisted around to face me. His mouth lashed out proboscis-like and nuzzled into the flesh of my arm.
Pain bristled out from where the boy had latched on to me. I screamed, thrashed. I shoved the car door open and tumbled out onto the asphalt. The boy coughed once and died.
At first the wound held all my attention. How could it not? I had expected to see torn flesh and blood but instead the boyâs distended mouth had left behind a cluster of thick, festering ulcerations.
But then I became aware of the men making their way out of the tall grass. These were the Fathers of Jebsen understood immediately what had happened.
They had brought everything they might need to bring one of their Children back home to its basement; rope, bandages and cudgels. It was also everything they needed to make a captive of me.
They, dragged me away from the accident site, through the tall grass and over the collapsed remains of a chain link fence to leave me in the care of the Mothers of Jebsen. Those gaunt women had cudgels of their own and I was a mass of bruises and welts by the time the hole in the Earth had been made to their standards.
The menfolk returned carrying the child wrapped in a linen shroud. They dropped it roughly into the ground. There were no ceremonies, tears or headstone. It was well after dark by the time I had filled the grave back in.
Now here it is years later and Iâve had to dig a dozen more graves, one by one the Mothers and Fathers are dying out, itâs always a surprise when it happens. Every mother and father of Jensen is withered and white haired but every year a few more die in their sleep, or at work in the fields or at prayer in their red brick observatory.
The Children are dying too, not a one has ever lived past seventeen. One by one they waste away, except of course for the occasional accident like the one that trapped me here.
Despite these curse that has befallen them the people of Jebsen continue to reproduce, each mother convinced that this time she will give birth to the Great Redeemer as was foretold in the Old Book. Each time they fail and each time the result is locked away in itâs familyâs basement.
You canât imagine those basements, the smell of rotten meat, the ankle deep fecal matter and the perfectly clean toys. They draw equations on the walls, gold and silver crayons are their preferred color. Every Tuesday I have to visit each of those cellars and scrub the theorems and postulations away.
The youngest of the Children is a newborn, still angry from the womb, the oldest is seventeen and nearly rotted away. No matter the age they all taunt me as I work, sometimes with bites, sometimes with maledictions. Both have left unimaginable scars.
So many scars now, Iâm marked, I could never walk among the people Iâd known before. Theyâd refuse to recognize me and insist I was a stranger
The Widow Thoth says this is my penance for the death of Julius McCarty, she even went so far as to cite chapter and verse on the subject from Old Book itself. The Mothers and Fathers of Jebsen, base every aspect of their lives on that thick volume of prophecies and homilies.
I wonder if anyone will notice me as leaving. I doubt it, even when theyâre not screaming their heads off a long dead suns they barely notice my comings and goings.
As I said before, the Mothers and Fatherâs of Jebsen have become so sure of me. Some families think Iâve become a true believer, the rest think the cinder block chained to my ankle is enough to keep me in my place.
I donât know who you are or when youâll find this message. My only hope is that you will believe me. If you do, please bring this document to the proper authorities. Donât let my death be for nothing.
I go to the bottom of the swamp with two regrets. One is that I wonât be there when the town of Jebsen is discovered and burned to the ground.
The other is that six months ago I accepted Father Garettâs invitation to join in their celebrations. I went willingly with them to the old brick observatory. I prayed with them. I danced with them. I partook in all of their debasements.
And for a little while, perhaps an hour, I was happy.
They even asked me to give reading from the Old Book. I eagerly stopped up to the podium and began flipping through the thick volume.
Everyone waited for me to choose a passage and speak but all I did was shake and weep at what I beheld. My knees buckled. My mind shut down. I had to be carried out and put to bed.
You see, the Old Book was blank from cover to cover. Youâre even holding some of those pages in your hands now.
I used them to write my story.
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2024.05.16 16:23 ChannelAb3 How I Wonder What You Are by Al Bruno III
Iâll know the time is right when the howling begins. It will be after sundown of course, the Mothers and Fathers of Jebsen only scream after sundown, and only on the clearest of nights.
There is no town of Jebsen listed on any map, even in its heyday of the 1940âs it was too small to be worthy of notice. Itâs nothing more than a collection of buildings at the end of a dead end road. On one side it is bordered by long untended corn fields, on the other the swampy remains of Lake Campbell. The most noticeable of the townâs buildings is a red brick edifice with a wide domed roof of fractured glass. The rest is just barns and single story homes. Along the border of the swamp is row after row of barbed wire and bear traps.
Iâll let them scream for an hour or so, let them become tired. Even now it amazes me how I had learned to pick out the individual voices in the cacophony. The Widow Toth tires easily but the Garrets will be at it until dawn.
And what will I be doing while every able-bodied adult is on the rooftops? Iâll be slipping these pages into this mason jar and sealing it lid in place with the wax from a melted crayon. The Children of Jebsen wonât miss just one, especially not purple.
Twenty-five years ago a calamity befell the town of Jebsen. The authorities blamed it all on the after effects of an experimental insecticide but the Old Book the town elders read from every Sunday said otherwise. It told the citizens of Jebsen that a curse was carried by those twinkling dots in the sky. A malevolence traveling at 186,000 miles per second that would twist their Children into nightmares should a glint of it ever touch their skin.
That is why they scream at the starlight; hating it, cursing it, raging at it.
You canât see what their Children have become and not feel the same way. The changes are heartbreaking and horrifying all at once but after you spend time with them you feel differently. There is mockery in the mis-set eyes that peer from those mollified skulls.
They know secrets. On quiet, cloudy nights I would put my ear to one familiesâ basement door or another and hear them murmuring and giggling as they writhe in their basement styes.
I think of their weeping mouths and soft teeth and remember that day half a decade ago the ill-advised shortcut and along the neglected county route 99. I remember approaching the train bridge and seriously considering turning around, it looked decades out of repair and I half suspected it would collapse as I passed under it.
But I didnât turn back, my ego wouldnât let me. I was right and the road was wrong so I drove under the train bridge, momentarily marveling at the strange and elaborate graffiti that covered it.
I was just past the structure when a small, bent figure ran out from the long grass.
The sounds are what I really remember; the squeal of the brakes, the thud of the body on the hood of my car, the thick crack of laminated glass.
I would later learn the name of the child I had hit was Julius McCarty but all I knew then was that there was an emaciated, bloodied shape lying halfway through my windshield.
Human instinct made me reach out, to see if the little boy was alive. When my fingers brushed his skin he twisted around to face me. His mouth lashed out proboscis-like and nuzzled into the flesh of my arm.
Pain bristled out from where the boy had latched on to me. I screamed, thrashed. I shoved the car door open and tumbled out onto the asphalt. The boy coughed once and died.
At first the wound held all my attention. How could it not? I had expected to see torn flesh and blood but instead the boyâs distended mouth had left behind a cluster of thick, festering ulcerations.
But then I became aware of the men making their way out of the tall grass. These were the Fathers of Jebsen understood immediately what had happened.
They had brought everything they might need to bring one of their Children back home to its basement; rope, bandages and cudgels. It was also everything they needed to make a captive of me.
They, dragged me away from the accident site, through the tall grass and over the collapsed remains of a chain link fence to leave me in the care of the Mothers of Jebsen. Those gaunt women had cudgels of their own and I was a mass of bruises and welts by the time the hole in the Earth had been made to their standards.
The menfolk returned carrying the child wrapped in a linen shroud. They dropped it roughly into the ground. There were no ceremonies, tears or headstone. It was well after dark by the time I had filled the grave back in.
Now here it is years later and Iâve had to dig a dozen more graves, one by one the Mothers and Fathers are dying out, itâs always a surprise when it happens. Every mother and father of Jensen is withered and white haired but every year a few more die in their sleep, or at work in the fields or at prayer in their red brick observatory.
The Children are dying too, not a one has ever lived past seventeen. One by one they waste away, except of course for the occasional accident like the one that trapped me here.
Despite these curse that has befallen them the people of Jebsen continue to reproduce, each mother convinced that this time she will give birth to the Great Redeemer as was foretold in the Old Book. Each time they fail and each time the result is locked away in itâs familyâs basement.
You canât imagine those basements, the smell of rotten meat, the ankle deep fecal matter and the perfectly clean toys. They draw equations on the walls, gold and silver crayons are their preferred color. Every Tuesday I have to visit each of those cellars and scrub the theorems and postulations away.
The youngest of the Children is a newborn, still angry from the womb, the oldest is seventeen and nearly rotted away. No matter the age they all taunt me as I work, sometimes with bites, sometimes with maledictions. Both have left unimaginable scars.
So many scars now, Iâm marked, I could never walk among the people Iâd known before. Theyâd refuse to recognize me and insist I was a stranger
The Widow Thoth says this is my penance for the death of Julius McCarty, she even went so far as to cite chapter and verse on the subject from Old Book itself. The Mothers and Fathers of Jebsen, base every aspect of their lives on that thick volume of prophecies and homilies.
I wonder if anyone will notice me as leaving. I doubt it, even when theyâre not screaming their heads off a long dead suns they barely notice my comings and goings.
As I said before, the Mothers and Fatherâs of Jebsen have become so sure of me. Some families think Iâve become a true believer, the rest think the cinder block chained to my ankle is enough to keep me in my place.
I donât know who you are or when youâll find this message. My only hope is that you will believe me. If you do, please bring this document to the proper authorities. Donât let my death be for nothing.
I go to the bottom of the swamp with two regrets. One is that I wonât be there when the town of Jebsen is discovered and burned to the ground.
The other is that six months ago I accepted Father Garettâs invitation to join in their celebrations. I went willingly with them to the old brick observatory. I prayed with them. I danced with them. I partook in all of their debasements.
And for a little while, perhaps an hour, I was happy.
They even asked me to give reading from the Old Book. I eagerly stopped up to the podium and began flipping through the thick volume.
Everyone waited for me to choose a passage and speak but all I did was shake and weep at what I beheld. My knees buckled. My mind shut down. I had to be carried out and put to bed.
You see, the Old Book was blank from cover to cover. Youâre even holding some of those pages in your hands now.
I used them to write my story.
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2024.05.16 16:21 ChannelAb3 How I Wonder What You Are
Iâll know the time is right when the howling begins. It will be after sundown of course, the Mothers and Fathers of Jebsen only scream after sundown, and only on the clearest of nights.
There is no town of Jebsen listed on any map, even in its heyday of the 1940âs it was too small to be worthy of notice. Itâs nothing more than a collection of buildings at the end of a dead end road. On one side it is bordered by long untended corn fields, on the other the swampy remains of Lake Campbell. The most noticeable of the townâs buildings is a red brick edifice with a wide domed roof of fractured glass. The rest is just barns and single story homes. Along the border of the swamp is row after row of barbed wire and bear traps.
Iâll let them scream for an hour or so, let them become tired. Even now it amazes me how I had learned to pick out the individual voices in the cacophony. The Widow Toth tires easily but the Garrets will be at it until dawn.
And what will I be doing while every able-bodied adult is on the rooftops? Iâll be slipping these pages into this mason jar and sealing it lid in place with the wax from a melted crayon. The Children of Jebsen wonât miss just one, especially not purple.
Twenty-five years ago a calamity befell the town of Jebsen. The authorities blamed it all on the after effects of an experimental insecticide but the Old Book the town elders read from every Sunday said otherwise. It told the citizens of Jebsen that a curse was carried by those twinkling dots in the sky. A malevolence traveling at 186,000 miles per second that would twist their Children into nightmares should a glint of it ever touch their skin.
That is why they scream at the starlight; hating it, cursing it, raging at it.
You canât see what their Children have become and not feel the same way. The changes are heartbreaking and horrifying all at once but after you spend time with them you feel differently. There is mockery in the mis-set eyes that peer from those mollified skulls.
They know secrets. On quiet, cloudy nights I would put my ear to one familiesâ basement door or another and hear them murmuring and giggling as they writhe in their basement styes.
I think of their weeping mouths and soft teeth and remember that day half a decade ago the ill-advised shortcut and along the neglected county route 99. I remember approaching the train bridge and seriously considering turning around, it looked decades out of repair and I half suspected it would collapse as I passed under it.
But I didnât turn back, my ego wouldnât let me. I was right and the road was wrong so I drove under the train bridge, momentarily marveling at the strange and elaborate graffiti that covered it.
I was just past the structure when a small, bent figure ran out from the long grass.
The sounds are what I really remember; the squeal of the brakes, the thud of the body on the hood of my car, the thick crack of laminated glass.
I would later learn the name of the child I had hit was Julius McCarty but all I knew then was that there was an emaciated, bloodied shape lying halfway through my windshield.
Human instinct made me reach out, to see if the little boy was alive. When my fingers brushed his skin he twisted around to face me. His mouth lashed out proboscis-like and nuzzled into the flesh of my arm.
Pain bristled out from where the boy had latched on to me. I screamed, thrashed. I shoved the car door open and tumbled out onto the asphalt. The boy coughed once and died.
At first the wound held all my attention. How could it not? I had expected to see torn flesh and blood but instead the boyâs distended mouth had left behind a cluster of thick, festering ulcerations.
But then I became aware of the men making their way out of the tall grass. These were the Fathers of Jebsen understood immediately what had happened.
They had brought everything they might need to bring one of their Children back home to its basement; rope, bandages and cudgels. It was also everything they needed to make a captive of me.
They, dragged me away from the accident site, through the tall grass and over the collapsed remains of a chain link fence to leave me in the care of the Mothers of Jebsen. Those gaunt women had cudgels of their own and I was a mass of bruises and welts by the time the hole in the Earth had been made to their standards.
The menfolk returned carrying the child wrapped in a linen shroud. They dropped it roughly into the ground. There were no ceremonies, tears or headstone. It was well after dark by the time I had filled the grave back in.
Now here it is years later and Iâve had to dig a dozen more graves, one by one the Mothers and Fathers are dying out, itâs always a surprise when it happens. Every mother and father of Jensen is withered and white haired but every year a few more die in their sleep, or at work in the fields or at prayer in their red brick observatory.
The Children are dying too, not a one has ever lived past seventeen. One by one they waste away, except of course for the occasional accident like the one that trapped me here.
Despite these curse that has befallen them the people of Jebsen continue to reproduce, each mother convinced that this time she will give birth to the Great Redeemer as was foretold in the Old Book. Each time they fail and each time the result is locked away in itâs familyâs basement.
You canât imagine those basements, the smell of rotten meat, the ankle deep fecal matter and the perfectly clean toys. They draw equations on the walls, gold and silver crayons are their preferred color. Every Tuesday I have to visit each of those cellars and scrub the theorems and postulations away.
The youngest of the Children is a newborn, still angry from the womb, the oldest is seventeen and nearly rotted away. No matter the age they all taunt me as I work, sometimes with bites, sometimes with maledictions. Both have left unimaginable scars.
So many scars now, Iâm marked, I could never walk among the people Iâd known before. Theyâd refuse to recognize me and insist I was a stranger
The Widow Thoth says this is my penance for the death of Julius McCarty, she even went so far as to cite chapter and verse on the subject from Old Book itself. The Mothers and Fathers of Jebsen, base every aspect of their lives on that thick volume of prophecies and homilies.
I wonder if anyone will notice me as leaving. I doubt it, even when theyâre not screaming their heads off a long dead suns they barely notice my comings and goings.
As I said before, the Mothers and Fatherâs of Jebsen have become so sure of me. Some families think Iâve become a true believer, the rest think the cinder block chained to my ankle is enough to keep me in my place.
I donât know who you are or when youâll find this message. My only hope is that you will believe me. If you do, please bring this document to the proper authorities. Donât let my death be for nothing.
I go to the bottom of the swamp with two regrets. One is that I wonât be there when the town of Jebsen is discovered and burned to the ground.
The other is that six months ago I accepted Father Garettâs invitation to join in their celebrations. I went willingly with them to the old brick observatory. I prayed with them. I danced with them. I partook in all of their debasements.
And for a little while, perhaps an hour, I was happy.
They even asked me to give reading from the Old Book. I eagerly stopped up to the podium and began flipping through the thick volume.
Everyone waited for me to choose a passage and speak but all I did was shake and weep at what I beheld. My knees buckled. My mind shut down. I had to be carried out and put to bed.
You see, the Old Book was blank from cover to cover. Youâre even holding some of those pages in your hands now.
I used them to write my story.
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joinmeatthecampfire [link] [comments]
2024.05.16 15:56 Megan_8r Mesalamine Dying Toilet
Hi! My 7yo son was recently diagnosed with Ulcerative Colitis - moderate to severe pancolitis.
He is currently on the highest dose of mesalamine which is changing his urine to a brown. Of course, when this hits the toilet seat, it dyes them. I have tried so many products trying to get the staining off my seats but it won't budge.
Does anyone with more experience have any suggestions? Different style seat? Special product? Or is this just something we have to live with?
Also - if anyone has any experiences with a child that was diagnosed so young, will you share your story? Good or bad - I just like being prepared. Nobody in our family or close community has UC that I can find to reach out to.
Also - If mesalamine hasn't worked for you, did Remicade? How are the side effects? What do you feel like after a treatment? That's what they're wanting to try next and I have a lot of fear that he will become immune and then what options are left?? Ugh. I'm so overwhelmed.
Thanks!!
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2024.05.16 15:45 Connect-Heron-401 Aloe vera
Habitat and cultivation Native to East and South Africa. It is now widely cultivated worldwide (potted aloe, low in anthraquinones). Aloe vera can be propagated by new shoots from the roots. Cutting the leaves or drying the leaves can collect the gel and juice.
Main functions Healing wounds Emollient Stimulate bile secretion
Practical application Beauty Aloe has a long history of being used to moisturize the skin. Western Remedies In the 1950s, Westerners first discovered that aloe vera was useful for burns, especially for radiation damage. As a result, aloe therapy has become popular. First aid treatment Aloe Vera is an excellent emergency care remedy for burns, abrasions, scalds, and sunburns. Break up an aloe leaf, squeeze out the gel inside and apply it to the affected area to get good results. Skin State Gel is suitable for almost all skin types that need to be soothed and tightened, and to a certain extent, it can also relieve varicose veins. Anabrosis The protective and healing effects of Aloe Vera on ulcers can also work inside the body, and the gel has a certain effect on peptic ulcers and irritable bowel syndrome. Laxative The yellow, bitter sap extracted from the leaves of Aloe vera contains anthraquinone, a powerful laxative. It can cause the colon to contract and defecate 8 to 12 hours after taking the medicine. Low doses of juice can promote digestion, and high doses of juice can be used as diarrhea.
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tragedeigh [link] [comments]
2024.05.16 14:45 thelansis Bone and Joint Infection â Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033
| https://preview.redd.it/3b9g5hu4bs0d1.jpg?width=1275&format=pjpg&auto=webp&s=79cc19679b5949b7a540e7e69f77bbc47f83b382 Bone and joint infections present formidable challenges in management and often lead to severe morbidity. They can instigate acute sepsis, destroying bone and joint tissues, chronic pain, persistent discharge from wounds, and lasting disability. Spinal infections typically arise either through hematogenous spread or post-surgical complications. Diagnostic imaging, primarily MRI (or CT if MRI is unsuitable), is essential for detecting signs of epidural abscess, discitis, vertebral osteomyelitis, and, crucially, indications of spinal cord or cauda equina compression, or vertebral instability necessitating urgent surgical intervention. Acute septic arthritis can affect any joint, with the knee being the most commonly affected, though wrists, ankles, hips, and the symphysis pubis may also be involved. Fever and localized pain typically manifest in acute osteomyelitis, while other skeletal sites should be evaluated as multifocal osteomyelitis is plausible. Diabetic foot infections frequently arise after skin ulceration in patients with neuropathy and vascular insufficiency. Glycopeptides, such as vancomycin and teicoplanin, are utilized in bone and joint infections at elevated doses, typically vancomycin at 10â12 mg/kg and teicoplanin at 10 mg/kg. Thelansisâs âBone and Joint Infection Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Bone and Joint Infection treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China). KOLs insights of Bone and Joint Infection across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs. Bone and Joint Infection Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights. Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources. Read more: Bone and Joint Infection â Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033 submitted by thelansis to u/thelansis [link] [comments] |
2024.05.16 14:21 thelansis Type 1 Diabetes Mellitus (T1D) â Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033
| https://preview.redd.it/22plzccs6s0d1.jpg?width=530&format=pjpg&auto=webp&s=29ccea2f9b03d890cc77a4a4d161cbb90dc7362e Type 1 Diabetes Mellitus (T1D) is characterized as an autoimmune disorder resulting in the autoimmune destruction of insulin-producing pancreatic beta cells. This condition necessitates life-long insulin replacement, administered through multiple daily insulin injections, insulin pump therapy, or an automated insulin delivery system. The absence of insulin can lead to the development of Diabetic Ketoacidosis (DKA), a life-threatening condition. The most common symptoms associated with this disease are polyuria and polydipsia. Effective management of T1D involves: - Multiple daily insulin injections
- Insulin pump therapy
- An automated insulin delivery system in conjunction with glucose monitoring
Continuous Glucose Monitoring (CGM) is the preferred method. However, all individuals with T1D should be capable of performing Blood Glucose Monitoring (BGM) via capillary blood if CGM is not available. Acute complications of diabetes primarily include hypoglycemia and severe hyperglycemia, which can lead to DKA. Chronic complications encompass a range of conditions including Nephropathy, Peripheral and Autonomic Neuropathy, Retinopathy/Macular Edema, Heart Disease (encompassing Coronary Artery Disease, Heart Failure, and Cardiomyopathy), Peripheral Arterial Disease, Cerebrovascular Disease (including Stroke and Transient Ischemic Attack), Hearing Loss, and Diabetic Foot Diseases (including Foot Ulcers and Amputations). - In the United States, the incidence rate of T1D is reported to be 19 per 100,000 population.
Thelansisâs âType 1 Diabetes Mellitus (T1D) Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033" covers disease overview, epidemiology, drug utilization, prescription share analysis, competitive landscape, clinical practice, regulatory landscape, patient share, market uptake, market forecast, and key market insights under the potential Type 1 Diabetes Mellitus (T1D) treatment modalities options for eight major markets (USA, Germany, France, Italy, Spain, UK, Japan, and China). KOLs insights of Type 1 Diabetes Mellitus (T1D) across 8 MM market from the centre of Excellence/ Public/ Private hospitals participated in the study. Insights around current treatment landscape, epidemiology, clinical characteristics, future treatment paradigm, and Unmet needs. Type 1 Diabetes Mellitus (T1D) Market Forecast Patient Based Forecast Model (MS. Excel Based Automated Dashboard), which Data Inputs with sourcing, Market Event, and Product Event, Country specific Forecast Model, Market uptake and patient share uptake, Attribute Analysis, Analog Analysis, Disease burden, and pricing scenario, Summary, and Insights. Thelansis Competitive Intelligence (CI) practice has been established based on a deep understanding of the pharma/biotech business environment to provide an optimized support system to all levels of the decision-making process. It enables business leaders in forward-thinking and proactive decision-making. Thelansis supports scientific and commercial teams in seamless CI support by creating an AI/ ML-based technology-driven platform that manages the data flow from primary and secondary sources. Read more: Type 1 Diabetes Mellitus (T1D) â Market Outlook, Epidemiology, Competitive Landscape, and Market Forecast Report â 2023 To 2033 submitted by thelansis to u/thelansis [link] [comments] |
2024.05.16 05:26 Zealousideal_Disk412 Recent SLE diagnosis
Found out this week that I am positive for SLE, Iâve had some severe symptoms over the past few months ranging from bad stomach issues, mouth ulcers, blood blisters in my mouth, and extreme pain and fatigue. Itâs been really rough getting to this point of getting a diagnosis, and I nearly gave up as every doctor passed over my concerns for what seemed to be liability reasons. Now that I have some answers, does anyone have any insights on starting to navigate treatments and care? The flare up Iâve been having for the past few months now has been beyond awful, and Iâm looking forward to hopefully getting the care I need and eventually feeling like myself again.
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2024.05.16 05:17 advancedoxygen real-world outcomes of treating
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2024.05.16 03:45 caboose2006 Cutaneous Mast Cell Tumor
Hello. I have a Domestic shorthair cat. Spayed, 4 years old. 3kg. Right now we live in the Philippines but are moving to the US in 3 weeks. She's been diagnosed with Cutaneous Mast cell Tumor and it's on her lip, the same place where Feline Rodent Ulcers form (That's what we thought it was until the biopsy results) I've read that the best treatment is surgery, but the vet says that surgery will cause a problem with appetite.
https://imgur.com/a/WexQCXj
https://imgur.com/kKskrnx
The vet just wants to monitor it. The vets here are... Not so great. It took us a year and a half to find this one that even had the ability to do SOME tests in house. So regardless of the problem with appetite, I feel like the tumor is the more pressing issue. I'll feed this cat whatever she'll eat for the rest of her life if I have to. What do I do with this cat? Should I insist on surgury?
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2024.05.16 00:54 Moist-Dog3509 Dont know what to do
Hey, Iâm a male 20 struggling with skin problems, which my dermatologist has diagnosed as rosacea. Problem is when I see other photos I donât really think mine looks like all the other examples. My skin is burning and stinging, but worst of all it looks hella wierd, and I get super insecure going outside, and makes my confidence drop more than it already is from before.
Does anyone have a routine for me to fix this? I tried using my finacea prescription but this was the thing that made my skin start to burn and sting, mind you I have had the exact same skin problem happen frequently before(without doing any treatment), so it has been coming on and off for a while(maybe a year). I have this crust on the skin aswell giving it this yellow look, and I think the skin is weeping a lot of fluid.
The pharmacist told me to just wait a couple days and start finacea treatment again but Iâm feeling so hopeless, and I donât know if my skin will ever be good
Picture one is before starting finacea and picture two after 2 days of treatment
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2024.05.15 22:32 ihave10toes_AMA Lost mom to mystery illness, treated as stomach virus
My mom passed away in April and Iâm really trying to make sense of it. Iâd never seen her sick a day in my life, unless you count her sensitive stomach and treatment for high blood pressure. Then she was gone as soon as we got her a proper diagnosis. It sounds like Mesenteric Ischemia is very easy to miss, and I was frantically looking for posts about it while she was in the hospital. So I thought Iâd share this.
Mom started getting sick around Thanksgiving. By mid-December it was bad enough that she could not travel for Christmas. She thought she had a stomach virus and said she didnât have the energy to pack or drive and didnât trust her stomach for a 3 hour drive. She started eating smaller meals to manage the virus.
Mid-February was her first ER visit. She was admitted & stayed 2 nights. Diagnosis was severe dehydration. Her white blood cell count was high, liver and kidneys âwackyâ. She was nauseated, lethargic, foggy brain. CT examined her head, âevery organâ. They did an ultrasound and told her it was not an organ. She was eating full meals by the time she was released.
One of the doctors at the ER asked her why she was there. He really treated her as though she was overreacting, and likely made her hesitate to seek care any more urgently, despite her decline.
After release she was told her blood sugar levels were high. She was diagnosed with hypokalemia (low potassium). She started working on a pre-diabetic diet but remained nauseated.
Mid-March a CT scan showed hiatal hernia and infection of some kind. She was dehydrated again. She hired someone for at-home IV treatments. She was drinking bone broth and drinks with electrolytes. A stool sample showed good results & her dr scheduled more blood tests. She had lost 25-30 lbs by this point.
Her dr scheduled an upper GI and colonoscopy for May 1st to look for ulcers, hernia. Blood test confirmed elevated white blood cells are caused by an infection and theyâve ruled out cancer.
April 1 â Dr told her she had stomach ulcers. After colonoscopy and endoscopy the dr is worried about blood flow to stomach. After a CT scan, she is referred to a vascular surgeon. They will do an ultrasound and consultation.
April 9 â Biopsies from colonoscopy are clear. Dr diagnosed clogged arteries around the stomach. Mesenteric Ischemia diagnosis. Scheduled an appointment to insert stents or look to bypass surgery.
April 10 â Admitted to ER for failure to thrive. TPN set up for nutrition. Plan is to build up her strength for the surgery.
April 13 â Dr ordered Xray to check for a possible bowel obstruction, lactic acid test to look for dead tissue / sepsis, hemoglobin test to check for internal bleeding. Mom has upper GI pain & cannot control her bowels. Very weak, unable to get up & down from bed on her own.
April 14 â Bowel obstruction found, ordering another x ray before deciding how to proceed. Backing off meals but keeping TPN, in order to let her stomach rest. (she was barely touching her food at all). Since bloodwork looks ok they think it could resolve itself.
April 15 â Dr says vitals are good, sugar levels are good. Surgery delayed, not because she is too weak but because she seems better. (I think this info was relayed to me wrong). They assured us waiting will not cause permanent damage to organs or tissue. Blood flow âlooks betterâ and they âarenât even sure itâs a blockageâ now. Mom was able to do PT and OT but was extremely weak after. Surgeon impressed with cognition.
April 16 â Mom was in a lot of pain, and they thought it was from the PT & OT exertion. CT scan came back once again confirming the bowel obstruction. Intestines are dilated. Keeping TPN, antibiotics added to IV. Ordered another CT scan & fasting (other than TPN). Blood pressure was up & down all day. Feet swelling for the first time. Abdomen expanding to a degree my cousin noticed from her bedside.
April 17 âIn the middle of the night she became unresponsive. Dr found her stomach full of blood. Her esophagus tore where it meets her stomach due to weak tissue. Her stomach was full of blood. Sheâs too weak for stents or bypass and will not regain strength without that. Dr thinks at this point her body is infected from bowel perforations & cannot heal
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2024.05.15 19:41 Practical_Animal_554 Thank you for crowdfunding and updates
Hello everyone,
A few months ago I came here asking for help with fundraising for my father, an ex-navy veteran who was suffering from stage 4 brain cancer.
https://www.ketto.org/fundraisemy-father-is-suffering-from-glioblastoma-gbm-glioblastoma-multiforme-we-need-your-help-to-provide-for-his-treatment-877794 We lost my father to this terrible disease on 5th April 2024, just 4.5 months after first diagnosis. We are still shaken and we do not know if or when we will be able to come out of this. Our lives turned upside down in a span of 5 months. More importantly we weep thinking what my dad must have gone through when all this happened. This horrible disease crippled and killed a healthy man in 5 months.
I want to thank everyone who contributed and shared their wishes with us. This disease took everything from us but your help came as a small respite to our situation. I will keep this reddit account active for many years down the line as a mark of respect to my father and to help other cancer patients with our experiences. I hope I am able to reach a position to repay all your monetary help and kindness one day.
Please take care of your parents and your health. We often dont appreciate people and take them for granted when they are around and miss them terribly when they are gone. My eyes swelled with pride when navy officers came and saluted him after my father passed away. My father left a lasting legacy by helping people and fighting for justice even when he wasnât a beneficiary. We hope to make him proud one day.
Thank you!
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2024.05.15 18:31 Variable851 Venting here just because there's no one IRL that I can vent to that involved
53M. My father-in-law died last week and my mother-in-law (who is great) was moved in with us permanently. That's itself is not an issue. We will have to build a new house or move soon to accommodate her though. My wife has severe autoimmune arthritis and ulcerative colitis and she is bedridden most of the time. Severe pain, random swelling in her joints. Her treatment team is running out of medications to try. My mother went into the hospital by ambulance on the morning of my father-in-law's funeral (Monday) and multiple blood clots were found in her leg and she had emergency surgery. My father has Alzheimer's disease and it is difficult to leave him by himself while my mom is in the hospital but I don't have any other options. I can check on his location by phone since he still drives (for now). He has left the stove on at times which is very worrying. My mother-in-law is grieving hard so she is not much help and she does not drive so in an emergency, she could not take my wife or son anywhere. I have my own issues which I won't even bother addressing because there isn't time (here or IRL). It's fucking overwhelming. That's it. Just needed to get it out somewhere. No need for replies
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2024.05.15 12:23 rusticgorilla Republicans reject abortion exceptions for child rape victims, create abortion registries, and ban possession of abortion medication
If you are in the position to support my work, I have a patreon, venmo, and a paypal set up. Just three dollars a month makes a huge difference! No pressure though, I will keep posting these pieces publicly no matter what - paywalls suck. You can signup to receive a monthly email with links to my posts or subscribe to Keep Trackâs Substack (RSS link). Kansas
Despite voters overwhelmingly rejecting a constitutional amendment that would have allowed abortion restrictions in the state, Kansas Republicans passed several anti-abortion bills into law late last month, overriding the governorâs veto.
The first bill, HB 2436, makes it a crime to âcoerceâ someone into having an abortion. Democrats attempted to widen the scope of the bill to include all kinds of reproductive coercion, like pressuring someone to become or stay pregnant and prohibiting their access to birth control, and enshrine a right to âreproductive autonomy.â Republicans voted down the amendment.
The second bill, HB 2749, requires medical facilities and providers to (1) ask patients their reason for having an abortion and (2) report the data, including personal information about the patient, to the legislature every other year. Gov. Laura Kelly (D) agreed with the objections of Democrats and reproductive rights advocates, saying when she vetoed the bill that there is âno valid reason to force a woman to disclose to the legislature why she is seeking an abortion.â
- Democrats offered numerous amendments to HB 2749, including one to require men to report to the legislature their reasons for having a vasectomy and another requiring men to report why they are seeking treatment for erectile dysfunction. Republicans rejected all of them.
Finally, the Republican legislature overrode Kellyâs line-item veto allocating $2 million to the Pregnancy Compassion Awareness Program, created last year with a different veto override. The program is run by an anti-abortion group called the Kansas Pregnancy Care Network, which refers pregnant people to crisis pregnancy centers designed to use misleading information to discourage them from obtaining an abortion.
Louisiana
Louisianaâs legislature is doubling down on its anti-abortion laws, passing bills to increase criminalization and refusing to add exemptions to its abortion ban.
Earlier this month, the Louisiana House took up a bill passed by the Senate that would make it a crime, punishable by jail time, to possess abortion-inducing medication. SB 276, sponsored by 23 Republicans and one Democrat, was initially written to create a punishment for coercing someone into an abortion without their knowledge or consent (e.g. spiking a drink). However, House legislators recently added an amendment to the bill that classifies mifepristone and misoprostol as Schedule IV substances alongside some opioids and benzodiazepines. A pregnant person possessing the drugs for their own use could not be charged, but others who intend to distribute them to pregnant people seeking an abortion or store them for their own potential future use would face up to ten years in prison.
âNeither is a drug of abuse or dependence, and that is what the controlled drug schedule is for,â said [emergency room Dr. Jennifer] Avegno of the abortion drugs. âIt makes no scientific or medical sense to put these drugs in the same category as Xanax or Valium.â
Mifepristone is a drug that blocks a hormone called progesterone, which is necessary for a pregnancy to continue. Misoprostol causes uterine contractions, causing the body to expel the pregnancy tissue. Mifepristone is also used to treat Cushingâs disease, a hormonal disorder. Misoprostol is also used to induce labor, manage a miscarriage and in the treatment of ulcers. Neither are addictive. âPeople do not go around taking them and getting dependent and having bad outcomes because of it,â said Avegno. âItâs like saying your blood pressure medicine or insulin is a drug of abuse.â
A week later, Republicans on the House Criminal Justice Committee voted 7-4 to reject a bill to add rape and incest exceptions to the stateâs total abortion ban. House Bill 164, written by Democratic Rep. Delisha Boyd, would have allowed girls younger than 17 to have abortions if they became pregnant as the result of sexual assault.
âThat baby [in the womb] is innocent ⊠We have to hang on to that,â said committee member Rep. Dodie Horton, R-Haughton, who voted against the bill. Rep. Lauren Ventrella, R-Greenwell Spring, also voted against the legislation, saying the proposed law would be difficult to enforce. Teenagers who had consensual sex might feign rape or incest in order to get access to abortion services, she suggestedâŠ
Dr. Neelima Sukhavasi, a Baton Rouge doctor specializing in obstetrics and gynecology, also implored the lawmakers to approve Boydâs proposal. She and her colleagues have delivered babies for pregnant teenagers, including mothers as young as 13, since Louisianaâs abortion ban went into effect two years ago. These young pregnant people can experience health complications that affect them for the rest of their lives, Sukhavasi said, and sometimes donât have the mental capacity to handle the births. âOne of these teenagers delivered a baby while clutching a teddy bear,â she told the committee.
The Committee also killed three other bills: HB 56, to allow abortions in cases of spontaneous miscarriage or nonviable pregnancy; HB 63, to clarify that the removal of an ectopic pregnancy is not an abortion under state law; HB 293, to add protection for physicians who do not intend to induce abortion by prescribing certain medications.
Texas
Meanwhile, in Texasâa state that pioneered the war on women and reproductive rightsâa man initiated legal action to sue people who helped his former partner obtain an out-of-state abortion.
The man, Collin Davis, filed a petition in a state district court seeking permission to launch legal depositions to collect evidence for a potential lawsuit under a Texas law that contains civil liability for anyone who âaids and abetsâ an abortion. According to his lawyer, Jonathan Mitchell (who crafted the anti-abortion law), Davis is seeking to sue âco-conspirators and accomplicesâŠinvolved in the murder of [his] unborn child.â
âFathers of aborted fetuses can sue for wrongful death in states with abortion bans, even if the abortion occurs out-of-state,â he wrote. âThey can sue anyone who paid for the abortion, anyone who aided or abetted the travel, and anyone involved in the manufacture or distribution of abortion drugs.â
Molly Duane, a senior staff attorney with the Center for Reproductive Rights, described Mitchellâs statement and general approach as misleading âfearmongering.â
âPeople need to understand that it is not a crime to leave Texas or any other state in the country for an abortion,â said Duane, who is working with lawyers from the firm Arnold & Porter to represent the woman and others targeted in the Davis case. âI donât want people to be intimidated, but they should be outraged and alarmed.â Duane described the womanâs relationship with Davis as âtoxic and harmful.â
Mitchell also represents a different man who pursued a similar claim last year: Marcus Silva engaged Mitchell to sue the friends of his estranged wife for allegedly helping her obtain abortion pills. Evidence later revealed that Silva knew about the plans beforehand and did not intervene, likely intending to use the threat of legal action as a way of forcing his partner to halt divorce proceedings.
Mondayâs counterclaim illustrates, in painstaking detail, exactly how Silvaâaided by Mitchellâallegedly deployed this tactic. It was only after Brittniâs abortion was complete that Silva revealed he knew about the plan and, according to the lawsuit, threatened to turn her in if she didnât submit to his continued abuse. He even showed the police photographs of messages discussing the possibility of an abortion. âOnce I finally got home with the girls he had been drinking and he told me that he knew,â Brittni texted one friend. âHeâs using it against me.â In another message, she wrote, âNow heâs saying if I donât give him my âmind body and soulâ until the end of the divorce, which heâs going to drag out, heâs going to make sure I go to jail for doing it.â [âŠ]
The counterclaim points out another flaw in his argument: Silva himself âis responsible for the alleged injury for which he seeks to recover.â He âknew that Brittni planned to terminate her alleged pregnancy and acquiesced in accepting Brittniâs actions,â so âit would be unconscionable to permit him to benefit by changing his position now.â His claims, in short, are barred âby unclean hands,â because he effectively entrapped his estranged wifeâcovertly discovering her plan to terminate the pregnancy, then allowing her to go through with it for the express purpose of blackmailing her into staying with him.
Indiana
A three-judge panel of the Indiana Court of Appeals last month unanimously recognized a religious freedom challenge to the stateâs complete ban on abortion.
The case, brought by Hoosier Jews for Choice and four anonymous women of various faiths, alleges that the ban interferes with âtheir sincere religious beliefs that require and direct them to obtain abortionsâ criminalized since the law took effect in 2023. According to Jewish law, a fetus does not have personhood until birth, and abortion is required if the pregnancy endangers the life or health of the mother.
Brief of Hoosier Jews for Choice (and other plaintiffs): As indicated by the declarations of numerous rabbis, Judaism teaches that a fetus becomes a living person only at birth, and prior to that is considered part of the womanâs body, without independent rights. Abortion should occur and is mandated to end a pregnancy that may cause serious consequences to a womanâs mental or physical heath. Judaism also recognizes that physical health risks are not limited to those likely to cause substantial and irreversible impairment of a major bodily function. Judaism stresses the necessity of protecting the physical and mental health of the womanâa lifeâover the potential for life present in a zygote, embryo, or fetus. Therefore, restrictions that prevent a woman from obtaining an abortion where compelled by Jewish law, which mandates that the woman act to protect her physical or mental health, impose a substantial burden on that personâs religious exercise.
Under Indianaâs Religious Freedom Restoration Act (RFRA), âa governmental entity may not substantially burden a personÊčs exercise of religion,â defined to include âany exercise of religion, whether or not compelled by, or central to, a system of religious belief.â This means that arguments about whether plaintiffs are strictly observant are irrelevant; the law protects sincerely held religious views regardless of whether that view is idiosyncratic or unorthodox. However, even a law that imposes a substantial burden on the exercise of religion can be enforced if it is âthe least restrictive means of furthering [a] compelling governmental interestâ (the strict scrutiny test).
The state argued that abortion does not carry âreligious significanceâ and, even if it did, the abortion ban satisfies strict scrutiny because it is âsufficiently narrowly tailoredâ to âfurther the Stateâs interestâ in âprotecting human lives in the womb.â Throughout Indianaâs brief, the state attempts to use science to back up fetal personhood, extending developmental physiology to make unfounded claims that protected life unquestionably begins at conception:
In lower courts, the Stateâs compelling interest is not up for debate. In Cheaney v. State, the Indiana Supreme Court held that the Stateâs interest in protecting unborn children is âvalid and compellingâ from âthe moment of conception.â âŠA basic understanding of biology supports these holdings. âThat human fetuses are human beings is a scientific fact, not a theological claim.â Regardless whether an individual person believes this, âthe scientific consensusâ is that â[d]evelopment begins at fertilization,â after which the newly created âunicellular zygote divides many times and becomes progressively transformed into a multicellular human being through cell division, migration, growth, and differentiation.â âŠ. Science thus tells us that â[t]he act of performing an induced abortion during any stage of pregnancy, from fertilization up to birth, ends the life of an innocent human being.â The Stateâs interest in protecting unborn fetal life at any stage from intentional destruction accordingly is nothing less than âcompelling.â
A panel of the Indiana Court of Appealsâmade up of a Republican appointee and two Democratic appointeesâunanimously ruled against the state, upholding a lower courtâs injunction against the abortion ban as it applies to the plaintiffs. In the process, the court laid out a path for religious freedom challenges to abortion bans in other states and at the federal level.
The trial court found that absent a preliminary injunction, Plaintiffs would be irreparably harmed by the loss of their religious freedoms guaranteed by RFRA. A loss of First Amendment freedoms, which include the right to free exercise of religion, âfor even minimal periods of time, unquestionably constitutes irreparable injury.â... Without a preliminary injunction, Plaintiffs will suffer the loss of their right to exercise their sincere religious beliefs by obtaining an abortion when directed by their religion and prohibited by the Abortion Law. They also have shown their sexual and reproductive lives will continue to be restricted absent the injunction and as a result of the Abortion Law.
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