Sample of auto insurance change form
No such thing as stupid questions
2013.02.02 09:52 I_Miss_Claire No such thing as stupid questions
Ask away! Disclaimer: This is an anonymous forum so answers may not be correct
2013.05.23 19:10 SlimKlim A place to discuss the BMW E36, or the root of all that is good.
This subreddit is a safe haven for all things E36. Show off your latest projects, ask for purchasing or repair advice, share advice, stories and experiences.
2011.08.08 09:50 Muffinmaster19 MinecraftMemes
A place to post memes about Minecraft! Our Discord Server can be found in the sidebar below.
2024.05.15 15:00 Count_Fantismo Received wrong year end feedback from coach
At green light late April my coach told me I was M/S/S however when the form actually posted last week it came back as B/S/S. When I questioned her on this she said that I definitely “met” but came out below peers. Her reasoning and explanation seemed flawed and make it seemed like she had no clue how the sausage is actually made (for lack of a better analogy).
What is my course of action? I no longer have faith in this coach 1) as I don’t believe her 2) I don’t feel I was accurately represented nor do I feel proper diligence was performed. Heck, just four weeks ago I received a thank it forward OPA from my LEP!!
Can this be reported to HR or talent group lead? I am not expecting my rating to be changed. That almost never happens. I am more worried about this delaying future promos or opps.
At a minimum I will be requesting to change my coach.
Thanks 🙏
US>CONSULTING>SM
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deloitte [link] [comments]
2024.05.15 15:00 wisdom_and_frivolity Buckler's Boot Camp - Posted every wednesday for questions and training
This post is to provide a place for everyone to ask simple questions and chat about anything reasonably on topic. If someone posts something worthy of their own thread, let them know! Like wise, if a thread is personal or answered in the FAQ elsewhere on the subreddit, point them here!
If you didn't get a response in the last thread before the new one was made, feel free to post again!
FAQ:
/STREETFIGHTER FAQ | effort time! create threads with similar subjects please! |
Who should I start with? | |
Where can I find a basic overview of each character? | SF6 Universe Android and iOS, Supercombo.gg |
What does _____ mean? Is there a glossary? | The latest glossary thread, iPlayWinner General Glossary, Infil's glossary |
Where can I find character combos / bread-n-butters? | https://combotier.com/ |
How can I stop being bad? | For the new players struggling... |
What are footsies? | Footsie handbook, Juicebox's explanation of footsies, RPS footsies in SF6 |
How can I improve my execution? | |
What are 'advanced techniques'? | (some of these are old) Option selects, hit confirms, negative edge and input shortcuts, input buffering, tiger knee motion and kara cancel, plinking, pianoing, sliding, double tapping, links and frame data, safe jumps |
What controller should I get? | Check out /fightsticks, they're more than just fightsticks |
Where is everyone posting Avatar codes to copy? | Check out /SF6Avatars |
Where can I find replays of good players? | |
Where can I find good shows? When are they on? | |
Where are other fighting game communities? | fgc.network and mstdn.games twitter alternatives |
| supercombo.gg wiki-like |
| discord list |
| reddit list |
| Newbie fight club |
| Faulty Hands fight club For people with limited motor skills |
How can I get critique on my replays? | You can post here, or make your own thread. Up to you! |
What is the current version of the game? | The current version is Street Fighter V: Champion Edition Street Fighter 6 |
New rules starting June 1:
Rule 9, No Duplicates |
Multiple posts of links, video or discussions often would be submitted when new game news or a popular event occurs. To avoid duplicates, only one thread is kept and the rest are removed. An exception can be made if a week has passed and the content is still relevant. |
Rule 10, Negative posts on other players or their gameplay must remove the username |
Removing players name in highlight video is highly recommended. If names are not removed and the nature of the content can be perceived as demeaning, the content will be removed. |
* If your post is a celebration of your own achievements then this is not required. |
In order to abide by this rule, go to Multi-menu: Options -> Personal Info Display: change relevant settings to “Display Own Only” |
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wisdom_and_frivolity to
StreetFighter [link] [comments]
2024.05.15 14:59 No-Product-523 Another shower thought i had
Since Hazbin Hotel And Helluva boss share the same universe (unfortunately)
And I just thought of something
Since I.M.P kills Alot Of inbred Humans due their job
What if those imps unintentionally or unknowingly created a sinner that kills hellborns and eats them for substance and nothing more than substance
Since a sinner has to find a way to adapt to hell they may find ways to do so like killing demons lower in the hierarchy like succubi hellhounds imps and other hellborns and eating them
And what if some Sinners formed a support group for other Sinners who's life had changed because I.M.P
submitted by
No-Product-523 to
hazbin [link] [comments]
2024.05.15 14:57 SLYTHERIN_RC Anybody want a 1998 Kouki with 32,851 Original miles?
| I figured I’d see if anyone wants my Kouki. Before I continue to throw money at a car thats only been driven 50 miles in 2 years😳 (Pic of odometer when purchased and current mileage included) Otherwise its getting paint, bodywork and rust preventive undercoating, done for $7k 1998 “Kouki” 32,851 original miles Car was totalled by insurance in 2000, rebuilt 6 months later and issued reconstructed title. It was stored and sat for 22 years, I purchased it in 2022. Fuel tank was dropped and flushed, rusted pump and fuel sender, removed and replaced. 5 speed swap done by OneMotion Auto Warminster P.A. a respected JDM shop in December 2023. Car shifts gears smoothly and operates without any issue. All Dash gauges work after the swap and car is fully functioning. Power windows, sunroof,cruise control, power mirrors Ac/Heat all function. $1800 just in parts, for the 5 speed swap. I took over a year to source the best OEM/Nismo parts and best Aftermarket parts for the 5 speed swap from canada, japan, england and the U.S. The shifter assembly has been completely rebuilt with gktech springs to remove stock play and slack. All lock cylinders pulled and rekeyed so no other 240 key opens it 🥷 EGR Plate installed and delete done by OneMotion Auto during 5 speed swap. They also did a full run down on the car to make sure everything works as it should plus more than I can remember off the top of my head, I have the invoice for the 5 speed swap and all other laboparts. Mechanically its mint and ready to drive🙌🏽 Car comes with OEM front lip splitter(not attached) OEM USDM Foglights included (not attached) My stash of rare and discontinued OEM/Tomei parts, I have are not included in sale. But are available for purchase to car buyer for additional cost. 5 Speed Swap Parts List: 5 Speed OEM Trans Dust shield, Flywheel 5 speed OEM trans mount 5 speed OEM shifter gasket OEM Shifter, ring, Shift knob, shifter plate OEM Shifter rubber dust boots OEM Shifter trim bezel Nismo Trans mount rubber isolator ARP Flywheel bolts ARP Pressure Plate Bolts Clutch line/Master CylindeSlave OEM Clutch Pedal Assembly Driveshaft Shop S14 ABS Solid 1 Piece Driveshaft Wiring Specialties Auto to manual wiring harness GKTech shifter springs GKTech Brass shifter bushing Oem Brake pedal pad Leather shifter boot $150 in OEM small bushings, springs, clutch rebuild kit, shifter hardware parts etc etc etc New parts or service done in 2022-2023 prior to 5 speed swap: New EGR pipe New Spark plugs New fuel pump New fuel filter New engine belts New Brake pads New Brake rotors New Brake calipers New Brake master cylinder New thermostat Fresh oil change in August, oil filter Blutooth CD player all 4 speakers replaced, New tires all around last summer New wiper blades New Battery with 3 year warranty No trades at all!!! I have to many cars already. Serious Cash offers will be considered. I’d like $13,000 OBO cause thats what I’m out of pocket so far, but feel free to offer. The mileage has been Carfax verified, engine matched to vin and 3 independent Nissan USA Dealerships have confirmed the odometer, has never been removed or tampered. Car is rust free and I encourage any actual parties with actual money to contact me for detailed videos of vehicle. Had a bunch of people try to make me feel like a Chomo, but heres the facts. Its a real Kouki Its super low miles It runs and drives Its not a rusty shitbox Its technically one color It’s not on jack stands Its straight and body panels line up. So its in better condition than half the 240s out there. I don’t need to sell it, I just have too many cars and don’t use this one at all. submitted by SLYTHERIN_RC to 240sx [link] [comments] |
2024.05.15 14:56 QueenDianaSpencer How can I make sure she doesn’t feed my baby solids, without my consent
Arabic country here.
I have a 4 month old and I’m staying with my husband’s sister & mother. His sis is a middle aged unmarried lady with no kids and is horrible with kids in my opinion but I haven’t told her that.
I safely let my baby girl TASTE foods. There’s a method where she’s upright and I have it mushed to puree in my mouth and let her take a lick or 2 (banana, or apple) to the form of a sauce and that’s all. Maybe once a week. She’s on formula otherwise. I do that because she’s highly interested in foods like INSANELY food curious and in a safe way.
My husband’s sis keeps insisting we feed her. Once she put a chopped carrot in her mouth (while she was laying on her back) which is dangerous, she keeps saying she wants to feed her a banana, she will put the whole banana in her mouth and I kinda have to say “NO please that’s it.” And earlier today she begged to spoon feed her halawa, a dry sesame paste. I said ok as long as I mush it up with my mouth and finger feed her a small, half a pea sized dollop. Just a smear.
I’m scared she’s gonna feed my daughter behind my back.
She already took videos of my baby naked and sent it to a group chat that I wasn’t included in, and worse is she had poop smeared on her butt. (Diaper change) I only found out when a relative let it slip & told her the dangers of having these kinds of infant photos circulating on any online server. My jaw dropped because I had no idea she was taking careless pics of my baby and sharing it with the f*king world. My brothers other sisters quickly shushed the relative who accidentally let this is info slip, and tried to push me out of the room to pretend this never happened. They had her back. When I walked to the other room furious and trying to collect my composure, I heard them all telling that stupid sis in law to hurry and delete the video.
I came back in the room and gently tried to tell everyone that I think I know what’s going on, and how I don’t like anyone taking pics of my baby without clothes on. They said ok.
Now, how can I tell my stupid sis in law not to feed my baby behind my back, only i can? I feel like im being mean if i say it like that, or as if im attacking her. I wanna tell my husband to talk to her, but then ill be that wife who tells her husband everything behind their backs, and then they will think im sneaky
submitted by
QueenDianaSpencer to
beyondthebump [link] [comments]
2024.05.15 14:54 tikusmouse [Announcement] BCJP 13.4 is out! ft. redemption of Bakery Cat, Rurouni Kenshin Collab and many more!
13.4 BCJP Summary
Misc Additions New Cat Medal for beating new Clan of the Malevolent stage
New Gamatoto Area for Rurouni Kenshin Collab
New Feature, you can watch an ad to continue on a stage / double xp drop (There is probably a cooldown)
Misc Changes UR rewards now go up to 22700 UR
Clown Cat and Exorcist Cat can now be upgraded to +20
Gacha Changes - New Wargods Vajiras Uber 明智光秀 (Akechi Mitsuhide)
- New June Bride Uber ネコケーキマシン挙式 (June Bride Cat Machine)
- New Rurouni Kenshin collab banner
New Forms New Ultra Form
- The White Rabbit UF: Gain increased HP & Damage, Faster ATK Rate, Weaken/Slow/Strong vs Alien/Red. Sage Slayer. Piercing multi-hit like Naala
Requires Red B. Gem x2, Purple B. Gem x2, Blue B. Stone x5, Gold Catfruit Seed x1
New True Form
- Bakery Cat TF: Gain increased HP & range (320 range), area attack, Zombie Killer, Target Relic and Curse Immunity
Requires beating Doremi Revenge stage
New talents Ultra Talents
- Cat Machine: Attack interval reduction, Curse Immunity, 100% Barrier Breaker
Regular Talents
All units gain the standard +20% HP / + 20% Attack Talent
- Jizo's Mega Castle: Curse Immunity, Toxic Immunity, Surge Resist
- Shishilan Pasalan: 50% chance For Lv3 Mini-Wave, Slow Immunity, Weaken Resist
New Cat Combos Sea Serpent Daliasan + Li'l Fish Cat = Unit Speed Up (M) New Cat Units New Uber Rare
New Units Uber Rare
- June Bride Cat Machine: Weaken/Resistant vs Aku/Angel. 75% chance of Shield Pierce, 50% chance to Weaken for 120f
- New Wargod: LD (550 standing range, hits 450 ~800 range) unit with 100% chance to KB Black/Angel, 50% chance to create Lv1 Surge and Summon (Summon ability: 100% chance to KB all enemies, 800 range)
- Himura Kenshin (Collab): Backliner unit with Massive DMG vs Aku/White, Surge Immune
- Sagara Sanosuke (Collab): Mid-range unit with Resistant vs Zombie, Zombie Killer, 20% chance Savage Blow, Freeze Immunity, Omnistrike (hits -150 ~ 440 range, 390 standing range)
- Aoshi Shinomori (Collab): LD unit with Strong vs Floating/Angel, 50% chance to Freeze for 150f, Slow Immunity (hits 250 ~ 650 range, 400 standing range)
- Hajime Saitou (Collab): Rusher unit with Massive DMG vs Aku/Red. 100% chance of Shield Pierce, Omnistrike (hits -100 ~ 400 range, 200 standing range)
New Super Rare
- Li'l Kaoru Kamiya (Collab): 50% chance to weaken Floating for 200f
- Li'l Yahiko Myojun (Collab): Massive DMG vs Floating/Angel
New Rare
- Kenshin Cat (Collab). Strong vs Red/Alien
New Special
- New Egg from June Bride: Strong vs Zombie/Aku, Zombie Killer, Behemoth Slayer
Requires: Purple B. Stone x10, Red B. Stone x10
- Kaoru Cat (Collab). 20% chance to Weaken Black for 150f, 20% chance to Dodge Black for 60
New Enemies
- Sage / Red Kangaroo: 280 range, Multi-hit
- 4 new Collab Enemies
New stages Zero Legends
ZL 11-1: Zoge, B.B.Bunny, Miss Haka, Professor A, Zory
ZL 11-2: Einstein Doge, Black Gory, Troll Blogger, Oldhorn, Dark Doberman
ZL 11-3: Doge Base, Those Guys, The Thrillerz, Coffin Doge, Ultra Baa-Baa, Dread Bore, Zombear
ZL 11-4: Squirrel, Red Kangaroo, Merdusa, Fallen Bear
ZL 11-5: Surge Base, The Face, Croco, Znache, Zigge, Zeal
ZL 11-6: Alien Croco, CTO Seal, Space Jones, Einstein Doge, Red Kangaroo
Event Stages
Wrath: Restriction: Normal and Uber only
Revenge: Doremi with a lot of peon spam
- Clan of The Malevolents
- 3 New June Bride stages
- New Collab Stages, Baron and Dojo
New Crowns difficulties
- ??? the 13th gets 3 Crown difficulty with 200% magnification
- Yowling Village gets 3 Crown difficulty with 180% magnification
Links
https://clamchowder.pythonanywhere.com/update-aaaaa.html for Animations, stages and stats
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tikusmouse to
battlecats [link] [comments]
2024.05.15 14:53 aishwarya00 Legionella Testing Market: Industry Insights and Market Forecast
| https://preview.redd.it/7qfedbpp7l0d1.jpg?width=1640&format=pjpg&auto=webp&s=7b5ec1f2a3c2b2c650bddcc04d8e2e70a4f391f3 Industry Insights and Market Forecast Industry insights and market forecasts provide valuable information on market trends, drivers, challenges, and opportunities. Market research reports offer comprehensive analysis of key market players, market size, revenue projections, and growth prospects. Insights from industry experts and stakeholders help stakeholders make informed decisions and formulate effective strategies for market entry and expansion. The Legionella testing market is experiencing significant growth, driven by increasing awareness of Legionnaires' disease, stringent regulatory requirements, and the rising incidence of Legionella contamination in water systems worldwide. Legionella bacteria, particularly Legionella pneumophila, pose significant public health risks, leading to severe respiratory infections and potentially fatal pneumonia. As governments, healthcare facilities, hospitality industries, and water management authorities prioritize Legionella prevention and control measures, The global legionella testing market is forecast to expand at a CAGR of 8.5% and thereby increase from a value of US$298.2 Mn in 2024, to US$527.9 Mn by the end of 2031. Market Drivers: - Growing Concerns over Public Health: The growing incidence of Legionnaires' disease outbreaks, coupled with increasing public awareness of waterborne pathogens, underscores the importance of Legionella testing and monitoring in mitigating health risks. Stringent regulations and guidelines mandating Legionella risk assessments, water management plans, and routine testing drive market demand for Legionella testing solutions and services.
- Rising Adoption of Water Safety Management Programs: Healthcare facilities, hospitality establishments, commercial buildings, and industrial facilities implement comprehensive water safety management programs to prevent Legionella contamination and ensure water quality compliance. Legionella testing forms an integral component of these programs, facilitating early detection, risk assessment, and remediation strategies to safeguard public health and minimize legal liabilities.
- Advancements in Testing Technologies: Technological advancements in Legionella testing methodologies, including culture-based methods, molecular techniques, and rapid diagnostic assays, enhance detection sensitivity, accuracy, and turnaround times. Automated systems, multiplex PCR assays, and next-generation sequencing platforms enable high-throughput Legionella screening, strain typing, and genomic analysis, driving adoption across diverse end-user sectors.
Market Restraints: - Complexity of Sampling and Testing Protocols: Legionella testing entails complex sampling procedures, sample processing techniques, and laboratory analysis methods, posing challenges for end users, particularly those lacking specialized expertise or resources. Variability in sampling techniques, inconsistent test results, and false-negative outcomes may compromise the effectiveness of Legionella testing initiatives and undermine confidence in water safety management practices.
- Cost Constraints and Budgetary Pressures: Budgetary constraints, cost considerations, and resource limitations influence the adoption of Legionella testing services and technologies, particularly among small-scale facilities, municipalities, and non-profit organizations. The perceived high cost of Legionella testing, coupled with competing priorities for healthcare expenditures and infrastructure investments, may hinder market penetration and limit access to testing services in certain regions or sectors.
- Regulatory Compliance Challenges: Regulatory compliance requirements for Legionella testing vary across jurisdictions, leading to discrepancies in testing methodologies, reporting standards, and enforcement measures. Interpretation of regulatory guidelines, compliance with evolving standards, and alignment with best practices pose challenges for end users, testing laboratories, and regulatory authorities, potentially impacting market harmonization and global standardization efforts.
[ Get the full report to discover:]() https://www.persistencemarketresearch.com/market-research/legionella-testing-market.asp Market Opportunities: - Expansion of Legionella Testing Services: The outsourcing of Legionella testing services to accredited laboratories, environmental consulting firms, and water management specialists presents opportunities for market expansion and service diversification. Outsourced testing services offer cost-effective, scalable solutions, alleviate resource constraints, and ensure compliance with regulatory requirements, particularly for small-scale facilities or organizations lacking in-house testing capabilities.
- Emergence of Point-of-Use Testing Devices: The development of portable, point-of-use testing devices and rapid diagnostic kits for on-site Legionella detection facilitates real-time monitoring, immediate response, and decentralized testing strategies. Handheld immunoassay kits, lateral flow devices, and digital microbial detection platforms empower end users to conduct rapid Legionella screening, risk assessments, and remediation actions, enhancing water safety management effectiveness and public health protection.
- Integration of Digital Solutions and IoT Technologies: Integration of digital solutions, Internet of Things (IoT) technologies, and cloud-based platforms into Legionella testing workflows enables remote monitoring, data analytics, and predictive modeling for proactive risk management and regulatory compliance assurance. Sensor networks, smart water meters, and real-time monitoring systems provide continuous insights into water quality parameters, Legionella levels, and microbial trends, empowering stakeholders to make informed decisions and optimize water management strategies.
Market Segmentations: By Test Type: - Culture Media
- Urine Antigen Testing
- Direct Fluorescent Antibody
- PCR
By Application: - Water Testing
- IVD Testing
By End User: - Hospitals and Clinics
- Diagnostic Labs
- Water Treatment Industries
By Region: - North America
- Europe
- East Asia
- South Asia & Oceania
- Latin America
- Middle East & Africa
Regional Market Dynamics: - North America: The North American Legionella testing market is characterized by stringent regulatory frameworks, high awareness of Legionnaires' disease risks, and proactive risk management strategies adopted by healthcare facilities, hospitality sectors, and commercial building owners. Market players focus on providing comprehensive testing services, consulting expertise, and innovative solutions to address evolving regulatory requirements and public health concerns.
- Europe: Europe showcases a mature Legionella testing market, driven by robust public health infrastructure, harmonized regulatory standards, and collaborative initiatives to combat waterborne diseases. Accredited testing laboratories, environmental consulting firms, and water management companies play a pivotal role in offering Legionella testing services, risk assessments, and water safety management solutions tailored to diverse end-user needs and regulatory contexts across European countries.
- Asia-Pacific: The Asia-Pacific region presents untapped opportunities for Legionella testing market growth, propelled by rapid urbanization, infrastructure development, and increasing emphasis on healthcare quality and safety standards. Rising awareness of Legionella risks, regulatory reforms, and investments in water infrastructure drive demand for Legionella testing services and technologies, particularly in healthcare facilities, hospitality sectors, and industrial settings across Asia-Pacific markets.
Key Players: The Legionella testing market features a diverse array of key players, including: - Abbott
- Beckman Coulter, Inc.
- BD
- Bio-Rad Laboratories, Inc.
- BIOMÉRIEUX
- Eiken Chemical Co., Ltd.
- Hologic, Inc.
- Pro Lab Diagnostics Inc.
- QIAGEN
- F. Hoffmann-La Roche Ltd.
- Takara Bio Inc.
- Thermo Fisher Scientific Inc.
Market Trends & Latest Developments: - Automation and Robotics Integration: Adoption of automated sample processing systems, robotic liquid handlers, and high-throughput screening platforms streamlines Legionella testing workflows, enhances testing throughput, and reduces turnaround times, thereby improving operational efficiency and laboratory productivity.
- Genomic Surveillance and Epidemiological Studies: Genomic sequencing, phylogenetic analysis, and whole-genome sequencing (WGS) methodologies enable genomic surveillance of Legionella strains, outbreak investigations, and epidemiological studies to track transmission routes, identify genetic markers, and inform public health interventions for Legionnaires' disease control and prevention.
- Blockchain Technology for Data Integrity: Blockchain-based solutions for data management, cryptographic verification, and secure information exchange enhance data integrity, transparency, and traceability in Legionella testing processes, ensuring compliance with regulatory requirements, chain of custody protocols, and quality assurance standards.
Future Trends and Outlook: - Microfluidic Lab-on-a-Chip Devices: The development of miniaturized, microfluidic lab-on-a-chip devices for rapid Legionella detection, single-cell analysis, and multiplexed testing holds promise for future advancements in point-of-care diagnostics, environmental surveillance, and on-site Legionella monitoring in diverse settings, including healthcare facilities and water distribution systems.
- Artificial Intelligence (AI) and Machine Learning (ML) Applications: Integration of AI algorithms and ML models into Legionella testing platforms enables predictive analytics, anomaly detection, and pattern recognition for early warning systems, predictive risk assessment, and adaptive control strategies. AI-driven insights empower stakeholders to proactively manage Legionella risks, optimize water treatment processes, and minimize human error in decision-making, thereby enhancing overall water safety and public health protection.
- Collaborative Research and Interdisciplinary Approaches: Collaborative research initiatives, interdisciplinary collaborations, and knowledge-sharing networks foster innovation, standardization, and best practices in Legionella testing methodologies, quality assurance protocols, and data interpretation guidelines. Multidisciplinary partnerships between public health agencies, academic institutions, industry stakeholders, and regulatory bodies drive continuous improvement, capacity building, and global harmonization efforts in Legionella surveillance and control.
In conclusion, the Legionella testing market presents significant opportunities for innovation, collaboration, and market expansion, driven by increasing awareness of Legionnaires' disease risks, regulatory compliance requirements, and technological advancements in testing methodologies. As stakeholders across diverse sectors prioritize water safety, public health protection, and regulatory compliance, strategic investments in Legionella testing solutions, digital technologies, and collaborative partnerships will be essential to address emerging challenges, mitigate health risks, and ensure the sustainability of water systems in the dynamic global landscape. [ About Persistence Market Research:]() Business intelligence is the foundation of every business model employed by Persistence Market Research. Multi-dimensional sources are being put to work, which include big data, customer experience analytics, and real-time data collection. Thus, working on “micros” by Persistence Market Research helps companies overcome their “macro” business challenges. Persistence Market Research is always way ahead of its time. In other words, it tables market solutions by stepping into the companies’/clients’ shoes much before they themselves have a sneak pick into the market. The pro-active approach followed by experts at Persistence Market Research helps companies/clients lay their hands on techno-commercial insights beforehand, so that the subsequent course of action could be simplified on their part. Contact Persistence Market Research Teerth Technospace, Unit B-704 Survey Number - 103, Baner Mumbai Bangalore Highway Pune 411045 India Email: [ sales@persistencemarketresearch.com](mailto: sales@persistencemarketresearch.com) Web: https://www.persistencemarketresearch.com [ Follow Us: ]() LinkedIn Medium Twitter submitted by aishwarya00 to u/aishwarya00 [link] [comments] |
2024.05.15 14:48 Alioliou Unholy Nuke technical design
In the quiet hum of dread, they lie, nuclear weapons, stark against the sky. A dance of power, a deadly art, summoning stars, tearing worlds apart.
Oh, is there a beauty, a dreadful grace, in bringing forth a sun to eclipse in space? The fire's bloom, a mushroom's rise, a spectacle that both terrifies and mesmerizes.
The shockwave echoes, a thunderous call, through trembling air, it echoes all. The ground quakes beneath the blast's fierce kiss, leaving behind a wasteland, shattered bliss.
In this dance of destruction, a haunting glass forms, a testament to fury, to humanity's storms. Nuclear weapons, a paradox to behold, a symphony of chaos, a story untold.
Everyone agrees. From the primitive and ineffective Gun-type fission weapon, through the implosion design, to the intricate multi-stage Teller-Ulam designs of Soviet thermonuclear weapons, to today's tactical neutron bombs and, perhaps in the distant future, proton decay catalyzed by magnetic monopoles bombs... Nukes are amazing and wonderful. Isn't it? And even in fantasy worlds there are nuclear weapons. Or at least we can assume them. Who has not been tempted to change the Uranium-238 buffer of an H-bomb for the strange and unstable Octiron of Discworld to observe its destructive effects after detonation?
But one of the most suggestive and mysterious designs is that of the Unholy Nuke from the Adventure Time universe. What is its design? How does it really work? These questions torment me at night. They don't allow me to sleep...
The first thing to note is that the Unholy Nuke, from which the Lich came, is not a phylactery. The Lich does not seem to have a phylactery... or at least that is what you have been led to believe. The Unholy Nuke is indeed a phylactery. It is something like an inverted phylactery, or like a molecular horcrux. Instead of storing the soul and releasing it if it breaks, killing the Lich; it disperses the Lich's soul into billions of particles throughout the world after "breaking" or, rather, exploding.
And how do you destroy billions of particles, horcruxes at the atomic level? You simply can't. At least not through current methods of technology and magic... It is simply genius. But at the same time, as the soul of the Lich is scattered everywhere, in many materials and living beings, so is its power. This is how the world of Ooo changed in such a radical and strange way.
But, I'm going off the rails. Let's focus on the design of the Unholy Nuke. The first thing to keep in mind is that it is a nuclear device. And as such, it probably has a primary stage with an implosion design, just like thermonuclear and neutron bombs. This primary stage is simple: it consists of a hollow sphere of Plutonium-239 containing a small amount of Californium-252 or, perhaps, lithium-7 deuteride and tritium gas.
Plutonium, of course, is not pure. It is alloyed with gallium for reasons of practicality and corrosion resistance. In turn, a beryllium sphere surrounds the plutonium sphere or, perhaps, something more advanced, a neutron supermirror consisting of several thin, concentric layers of beryllium or nickel and titanium, to reduce the mass of plutonium necessary to achieve criticality. . This neutron-reflecting sphere that surrounds the plutonium sphere is covered by a thin layer of gold to be protected against corrosion. You already know that beryllium is easy to corrode.
And finally there are the explosive lenses, connected to detonators, made up of a fast high explosive and a slower one, with almost hexagonal or truncated pyramidal pentagonal shapes, a curved and convex outer face, and with the explosives forming a kind of paraboloid inside each lens. . These lenses surround the large metal sphere as if it were a soccer ball... But these details are insipid. You know what an atomic bomb looks like inside. Everybody knows. It is popular knowledge.
What interests us is the second stage, which is linked to the "unholy", to the Lich. What is it? What lies behind the first stage of the Unholy Nuke?
The second stage of the Unholy Nuke is a menacing and otherworldly device. A sphere of precipitated souls, forming a drop of amorphous unnatural glass. But inside this sphere there is something else: the core, the soul of the Lich. Its core resembles a pulsating, malevolent eye, surrounded by jagged obsidian-like fragments. This sphere of souls is surrounded by a concentric layer of U-238 that is activated, transmutes into plutonium-239 taking advantage of the neutrons released by the explosion of the first stage, and then fissions uncontrollably, imploding the sphere of souls at pressures and huge temperatures.
The uranium sphere's casing is encased in another, duller, purplish-looking material, perhaps hepatizon, thaumium, or some strange type of alchemical brass, adorned with cryptic symbols etched in bright crimson and infused with various evil aspectual essences. And finally, the entire set, the two stages of the Unholy Nuke, is surrounded by a kind of Cobalt-59 capsule, to give some salty flavor to the nuclear explosion. Cobalt-59 absorbs neutrons and transmutes into cobalt-60, which is lethally radioactive for decades or even centuries.
When activated, the Unholy Nuke emits an eerie hum that resonates in the souls of the damned. The primary nuclear explosion awakens the pulsating eye of the Lich, which harnesses chaotic energy, drawing power from the darkest corners of the multiverse.
When detonated, the device does not cause a traditional explosion, at least not for long; Rather, reality itself is deformed and fractured.The laws of physics are altered and localized anomalies are created: Gravity is reversed, causing objects to float or plummet unpredictably. Time loops form, trapping unfortunate beings in repetitive sequences, or skinning and eviscerating them in complex ways into hideously beautiful fractals of flesh and sinew.The dimensions overlap, allowing a glimpse of alternative realities. Existential dread intensifies (a standard characteristic of any self-respecting eldritch artifact).
The aftermath leaves behind a surreal landscape: twisted trees, spectral echoes and unexplained phenomena, as well as high levels of radiation... and high levels of mutagenic environmental magic.
The red runes on the second stage casing have no special function, beyond giving a dramatic effect. When activated, they whisper the forbidden incantation:
In eldritch shadows, evil unbound, Sacrifice a relic rare, profound. Spin clockwise thrice, in ritual sway, As Fibonacci's sequence, reversed, you say.
Unleash entropy, let it roam free, In whispered chants, dark symphony. Eldritchium malum, a forbidden art, Unraveling realms, tearing worlds apart.
Through arcane rites, a twisted dance, Summoning chaos, in devil's trance. Entwined with magic, a cosmic play, Where sanity fades, and horrors stay.
Now you know how the unholy nuke works. Beautiful, isn't it?
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2024.05.15 14:48 G-M-Dark Season 14 Story Arch - The Mavity of The Situation....
Go back to the 3-part David Tennant
Unit spin-off Davis established the groundwork for before Ncuti Gatwa took over - the episode
Wild Blue Yonder starts with a little skit featuring Isaac Newton in which the Tardis gets stuck in an apple tree while Newton is pondering important thoughts beneath and a bushel of apples falls on his bonce, causing him to have a little chat with the Doctor 10/14 and Donna - during which Newton mishears Donna's rather forced pun about the
gravity of the situation, which Newton mishears as
mavity....
And thus, from then on, gravity is forever
mavity - because that's how Newton termed it because he liked the sound of the word. The Doctor and Donna go far forward in time, and they both use the word without blinking.
It's supposed to be a throwaway gag but we run into the same story mechanic in both Season 14s opening episodes:
- After travelling back to the time of the dinosaurs at the start of Space Babies and setting up the punchline about the butterfly effect inside the Tardis, Ruby steps outside only to enact said temporal problem by stepping on a butterfly and the next thing we find is Ruby is replaced by some form of scaly creature called Rubathon Blue of the 57th Hemisphere Hatchlings who never makes mistakes and is quite prepared to kill you just to prove it...
- The Doctor rectifies the problem by breathing a bit of his life into the crushed insect, which gets better and flutters away - the preservation of its life ensuring Ruby Sunday comes to exist millions of years later.
- In The Devils Chord - overwhelmed with fear and forced to flee back to the Tardis during their encounter with Maestro back in 1963 Ruby believes they're safe, only for the Doctor to return her to the point in time they originally left to find reality a consequence of the Doctor and Ruby failing to defeat Maestro back in 1963 - the world is destroyed, forever in nuclear winter-the same snow falling as they've both encountered in the previous episode (Space Babies) - they have no choice but to return and face Maestro in 1963....
It's the same temporal mechanic being demonstrated - this time, in the later episode, to greater narrative effect: do something or fail to do something in the past, it doesn't create a separate timeline the present updates to accommodate whatever change.
Loki Season 2 used a similar narrative mechanic throughout - it's establishing the groundwork about what's coming and what needs to happen to fix the problem: knowing Davis's penchant for tear-jerking finales it's probably going to centre around Ruby and the Doctor having to leave her to a fate his intervention in which would otherwise cause the death of everyone else - forcing him to do the adult thing rather than pretend he has the luxury of being a giggly kid.
It's a note central to Davis's core concept of his Doctors - they may look happy superficially, but - scratch the surface, and they're carrying the weight of the universe on their shoulders, ground down by the burden of being the last of whatever the fuck he's supposed to be these days...
I'm paraphrasing at the minute, I'll fill in the blanks as the show rolls along.
How are you all finding it, assuming I'm not just chundering away to myself here...?
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2024.05.15 14:44 adulting4kids Archetypes
Archetypes, as defined by Swiss psychiatrist Carl Jung, are fundamental, universally recognized symbols and patterns that form part of the collective unconscious of humanity. These symbols and motifs are present across different cultures, religions, and mythologies, representing common human experiences, emotions, and characteristics.
In the context of tarot, archetypes play a significant role in understanding the symbolism and meaning behind the cards. Each tarot card embodies various archetypal themes, which help to convey deeper messages and insights during readings. Here's a brief exploration of some common archetypes and their relevance in tarot:
- The Fool: This archetype represents innocence, new beginnings, spontaneity, and a carefree spirit. In tarot, the Fool card often signifies embarking on a new journey, embracing risks, and seeking adventures.
- The Magician: Symbolizing manifestation, power, and resourcefulness, the Magician embodies the ability to channel energies and create change. It represents taking control of one's life and utilizing available resources to achieve goals.
- The High Priestess: This archetype is associated with intuition, mystery, and wisdom. The High Priestess card signifies accessing inner knowledge, spiritual insights, and the subconscious mind.
- The Empress: Representing nurturing, fertility, abundance, and maternal instincts, the Empress embodies creativity, growth, and a connection to nature and life cycles.
- The Emperor: Signifying authority, structure, leadership, and stability, the Emperor archetype represents order, organization, and the establishment of boundaries.
- The Lovers: This archetype embodies love, relationships, choices, and harmony. In tarot, the Lovers card often indicates significant decisions, partnerships, and the search for balance.
Understanding these archetypes helps tarot readers interpret the cards beyond their literal meanings. It allows for a deeper exploration of human experiences, motivations, challenges, and aspirations. By recognizing archetypal patterns in the cards, tarot readers can offer nuanced guidance that resonates with the universal themes and experiences shared by individuals seeking insights through tarot readings.
- The Hierophant: Representing tradition, wisdom, institutions, and spiritual guidance, the Hierophant embodies adherence to established beliefs and societal norms. It signifies seeking spiritual teachings and guidance from established sources.
- The Chariot: Symbolizing determination, willpower, control, and success, the Chariot archetype represents overcoming obstacles and achieving victory through focused effort and self-discipline.
- Strength: This archetype embodies inner strength, courage, resilience, and compassion. It represents the ability to face challenges with grace and kindness rather than force.
- The Hermit: Representing introspection, solitude, wisdom, and spiritual seeking, the Hermit archetype symbolizes a period of self-reflection, seeking inner guidance, and introspective growth.
- Wheel of Fortune: Symbolizing cycles, fate, destiny, and change, the Wheel of Fortune archetype signifies the ever-changing nature of life, cycles of growth, and the influence of external forces on one's journey.
- Justice: This archetype embodies fairness, balance, truth, and accountability. It represents the need for impartial judgment, integrity, and taking responsibility for one's actions.
- The Hanged Man: Signifying surrender, sacrifice, perspective shift, and spiritual awakening, the Hanged Man archetype represents a willingness to let go, gain new insights, and see things from a different angle.
- Death: Symbolizing transformation, endings, rebirth, and letting go of the old to embrace the new, the Death archetype represents profound changes, transitions, and personal growth.
- Temperance: This archetype embodies moderation, patience, balance, and harmony. It signifies blending opposing forces and finding equilibrium in life's various aspects.
- The Devil: Representing bondage, temptation, materialism, and unhealthy attachments, the Devil archetype highlights areas where one might feel restricted or trapped by worldly desires or negative influences.
- The Tower: Symbolizing sudden upheaval, disruption, revelation, and awakening, the Tower archetype represents moments of profound change, breakdown of old structures, and the need for rebuilding.
Understanding these archetypal themes in tarot cards allows tarot readers to delve deeper into the layers of symbolism and interpretative possibilities. It helps them offer nuanced guidance that resonates with individuals seeking insights or navigating various life situations.
- The Star: Symbolizing hope, inspiration, guidance, and renewal, the Star archetype represents optimism, times. It signifies healing, renewal, and faith in the future.
- The Moon: Representing intuition, subconscious, illusions, and cycles, the Moon archetype embodies mystery, hidden truths, and the exploration of deeper emotions. It signifies navigating uncertainties and trusting inner guidance.
- The Sun: Symbolizing success, joy, vitality, and enlightenment, the Sun archetype represents clarity, positivity, and a sense of achievement. It signifies newfound confidence, growth, and the fulfillment of ambitions.
- Judgment: This archetype embodies reflection, accountability, rebirth, and inner calling. It signifies self-evaluation, spiritual awakening, and embracing transformational opportunities.
- The World: Representing fulfillment, completion, unity, and accomplishment, the World archetype embodies wholeness, integration, and reaching a significant milestone. It signifies a sense of fulfillment and harmony in one's life journey.
- Fool's Journey: The Fool's Journey is an overarching archetype representing the progression of experiences and lessons depicted in the Major Arcana. It symbolizes the individual's journey through life, facing various challenges, gaining wisdom, and evolving spiritually.
- Shadow Self: While not a specific card, the concept of the shadow self is an archetype within tarot representing hidden or repressed aspects of one's personality. It signifies the need for self-awareness, confronting inner fears, and integrating overlooked aspects of the self for personal growth.
- Archetypal Patterns in Relationships: Understanding archetypal patterns in relationship-oriented cards (such as The Lovers, Two of Cups, Ten of Cups, etc.) can aid in interpreting dynamics, connections, and lessons within partnerships, friendships, or family relationships.
- Symbolism of Animals and Mythical Creatures: Exploring the archetypal significance of animals or mythical creatures depicted in tarot cards can provide additional layers of meaning and insight based on cultural and symbolic associations.
- Archetypal Journey of Self-Discovery: Using tarot cards to represent different stages of personal development and self-discovery, allowing individuals to explore archetypal themes relevant to their personal growth and transformation.
Recognizing and understanding these archetypes within tarot cards empowers tarot readers to offer deeper, more resonant guidance by tapping into the rich symbolism and universal themes embedded in the cards.
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2024.05.15 14:42 binnypie Split screen to default to show radio
I have a wireless Android Auto adapter and it connects and displays AA automatically when I turn on the car. I have split screen set up and I want it to default to show radio on the right and AA on the left. But it's showing Kia maps on the right and I have to scroll to display radio. I changed the order of the split screen options (can't deselect maps, annoyingly) and put radio on the top. It worked once or twice but now keeps defaulting to maps when I turn on the car. Any way to fix that? Is there another setting I'm missing?
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2024.05.15 14:41 louied91 Dyadic Announces First Quarter 2024 Financial Results and Highlights Recent Company Progress
News Link:
https://www.globenewswire.com/news-release/2024/05/14/2881828/0/en/Dyadic-Announces-First-Quarter-2024-Financial-Results-and-Highlights-Recent-Company-Progress.html Human Health Sector - Final Clinical Study Report has been issued for the First-In-Human Phase 1 clinical trial demonstrating safety and antibody response for DYAI-100, a recombinant protein receptor binding domain booster vaccine candidate for protection against COVID-19 infection
- Entered into several fully funded vaccine and antibody projects covering more than twelve targets, five of which are funded by two of the top ten pharmaceutical companies
- Successfully expressed a H1N1 influenza antigen in our collaboration with the Vaccine and Immunotherapy Center (“VIC”) at Massachusetts General Hospital
- Announced strategic partnership to develop affordable rabies prophylactics and vaccines using C1-cell protein production platform
- Published a manuscript of preclinical studies on C1 produced monoclonal antibody in non-human primates and hamsters in prestigious peer-reviewed journal Nature Communications
- Advanced collaboration with Israel Institute for Biological Research (IIBR) targeting bio-threats and emerging disease solutions
- C1 produced adjuvanted recombinant ferritin nanoparticle H5N1 “Bird Flu” human vaccine candidate demonstrated a strong immune response in animal studies
Animal Health Sector - C1 produced adjuvanted recombinant ferritin nanoparticle H5N1 “Bird Flu” human vaccine candidate demonstrated a strong immune response in animal studies for potential use in poultry, cattle and other animals
- Expanded collaboration with Phibro/Abic to develop vaccines and treatments for companion and livestock animal diseases
Alternative Proteins Sector - Executed a term sheet to utilize our microbial protein production platforms to develop production strains for the production of recombinant serum albumin
- Advanced development of 6 product candidates for non-pharmaceutical applications utilizing the Dapibus™ platform technology
Corporate - Closed a $6.0 million convertible note in a private placement, with a conversion price of $1.79 and no warrants
- Appointed Mr. Patrick Lucy as Board Chairman and Mr. Joe Hazelton as Chief Operating Officer
- Cash and investment grade securities of $12.1 million as of March 31, 2024
- Financial results and business update conference call scheduled for 5:00 p.m. ET today
JUPITER, Fla., May 14, 2024 (GLOBE NEWSWIRE) -- Dyadic International, Inc. (“Dyadic”, “we”, “us”, “our”, or the “Company”) (NASDAQ: DYAI), a biotechnology company focused on the efficient large-scale manufacture of proteins for use in human and animal vaccines and therapeutics, as well as non-pharmaceutical applications including food, nutrition, and wellness, today announced its financial results for the first quarter of 2024 and highlighted recent Company progress.
“We continue to execute our business strategy to focus on near-term pharmaceutical and non-pharmaceutical applications for our proprietary and patented C1 and Dapibus™ protein production platforms and pipeline products,” said Mr. Mark Emalfarb, President and CEO of Dyadic. “One of our key highlights was the successful completion of a Phase 1 clinical trial that met its primary endpoint of safety and reactogenicity affirming the safety of proteins produced by Dyadic's C1 platform in humans. We believe this milestone not only establishes the safety of our platform but also provides a solid foundation for C1 technology’s future applications in human and animal vaccines and therapeutics. With the H5N1 ('Bird Flu') virus outbreaks in poultry and U.S. dairy cows, along with one recent human case, we are seeing an increasing interest in our H5N1 'Bird Flu' ferritin nanoparticle human vaccine candidate, developed with ViroVax. Additional animal studies indicate that the vaccine candidate has the potential to generate high neutralizing antibodies for use in cattle. Our Q1 2024 achievements demonstrate our ongoing commitment to enhancing our microbial platforms for diverse applications, and our dedication to improving health for humans and animals, while tackling the challenges of sustainable food production.”
Mr. Emalfarb continued, “As we progress into the second quarter, our Company continues to focus on enhancing the Dapibus™ platform, designed specifically for non- pharmaceutical uses in industries such as food, nutrition, health, and other bioproducts. To accomplish this goal, we have honed our business development strategy, focusing on key areas where our technologies can deliver the greatest impact with shorter commercialization timelines. Our strategy includes simultaneously targeting multiple offtakes for a single product in several corresponding business segments and seeking out new opportunities that are in line with our strategy.”
Joe Hazelton, Dyadic’s Chief Operating Officer, elaborated, “In addition to operational advancements, we also strengthened our financial position with the issuance of $6.0 million in convertible notes, which will be used to accelerate and exploit our strategic objective of near-term revenue generating products and commercialization opportunities for pharmaceutical and non-pharmaceutical applications. We believe that product opportunities such as recombinant human albumin and alpha-lactalbumin provide Dyadic with multiple monetization opportunities as a licensed product or cell line in pharmaceutical, diagnostic, and food applications. We are confident that our strong position, both financially and scientifically, will enable us to implement our business plans with improved capabilities and resources. We are enthusiastic about our future prospects and remain committed to providing value to our customers and stakeholders.”
Recent Company Progress Corporate Events:
- On March 8, 2024, the Company issued an aggregate principal amount of $6.0 million of its 8.0% Senior Secured Convertible Promissory Notes due March 8, 2027 (the “Convertible Notes”) in a private placement in reliance on the exemption from registration provided by Section 4(a)(2) of the Securities Act of 1933, as amended. The purchasers of the Convertible Notes include immediate family members and family trusts related to Mark Emalfarb, our President and Chief Executive Officer and a member of our Board of Directors, including The Francisco Trust, an existing holder of more than 5% of the Company’s outstanding common stock.
- On March 28, 2024, the Company announced changes in the leadership roles of the Board and senior management team: the appointment of Mr. Patrick Lucy as Chairman of Board of Directors and promotion of Mr. Joe Hazelton to Chief Operating Officer.
~Human Health Sector~
DYAI-100 Phase 1 Clinical Trial DYAI-100, a C1-SARS-CoV-2 recombinant protein RBD vaccine candidate, is the first C1-expressed protein tested in humans. The Phase 1 randomized, double-blind, placebo-controlled trial was designed as a first-in-human trial to assess the clinical safety and antibody response of DYAI-100, produced using the C1 platform and administered as a booster vaccine at two single dose levels in healthy volunteers. Following regulatory clearance from the South African Health Products Regulatory Authority (SAHPRA), the trial was initiated in 1Q 2023, with the last patient visit occurring in 3Q 2023. On November 29, 2023, the Company announced the top-line safety results, indicating that the study has met its primary endpoint that both the low and high dose levels of the vaccine are safe and well tolerated among participants. Additionally, the vaccine has been shown to induce immune responses at both dose levels, suggesting its potential efficacy in generating protective immunity against the target virus. The study has been finalized, and the final Clinical Study Report has been issued, demonstrating that the DYAI-100 vaccine met its primary endpoint of safety and reactogenicity.
- In April 2024, Dyadic and its development partner ViroVax reported pre-clinical animal testing on a ferritin nanoparticle H5N1 bird flu recombinant protein human vaccine candidate that demonstrated a strong immune response in rabbits. The potential vaccine combines Dyadic’s C1 single step ferritin nanoparticle H5N1 antigen production with a novel adjuvant from ViroVax. Additional animal studies are being carried out that preliminarily show that this H5N1 bird flu vaccine has the potential to be used in humans.
- Successfully expressed H1N1 influenza antigen in the fully funded research collaboration with the Vaccine and Immunotherapy Center (“VIC”) at Massachusetts General Hospital to express vaccine antigens for influenza A and other infectious diseases, as part of a US $5.88 million award from the Department of Defense (“DoD”).
- On March 25, 2024, the Company entered a funded research collaboration with a top ten pharmaceutical company to develop a vaccine antigen and a monoclonal antibody produced from the C1 technology.
- In March 2024, a manuscript of preclinical studies on C1-produced monoclonal antibody in non-human primates and hamsters was published in the prestigious peer-reviewed journal Nature Communications. A non-human primate challenge study completed dosing of a C1-produced COVID-19 monoclonal antibody (mAb) that had previously demonstrated broad neutralization and protection against Omicron (BA.1 and BA.2) and the other earlier variants of concern in hamsters. Preliminary results obtained from the challenge study with the SARS-CoV-2 Delta virus on non-human primates demonstrated potential high protection. This was the first time a C1-produced monoclonal antibody was used in a non-human primate study validating the safety and efficacy of a C1 produced antibody for infectious diseases.
- On February 28, 2024, the Company’s Dutch subsidiary, Dyadic Nederland BV, entered into a strategic partnership agreement and collaboration with Rabian BV (“Rabian”), a Dutch innovative SME founded by experienced entrepreneurs and vaccine scientists. Awarded by Eurostars for the AVATAR project, a part of the European Partnership on Innovative SMEs (small and medium-sized enterprises), and co-funded by the European Union through Horizon Europe. Rabian will use the total funding of approximately Є1.7 million leveraging its expertise in virology to develop a rabies vaccine using Dyadic’s C1 protein production platform to tackle the challenges posed by rabies, particularly in lower- and middle-income countries. Dyadic is expected to receive an equity stake in Rabian, fully funded research and development costs, and specified product milestones and royalties upon commercialization.
- On February 21, 2024, the Company announced it has advanced its collaboration with the IIBR and its commercial arm Life Science Research Israel (LSRI), to target emerging disease solutions. This partnership aims to leverage Dyadic’s expertise in microbial platforms for flexible scale protein bioproduction and the IIBR’s antibodies and antigens discovery capabilities to develop and manufacture innovative solutions for addressing emerging diseases and potential bio-threats. Through this collaboration, both parties are working towards the development of effective treatments and vaccines to combat global health challenges with the intention of future commercialization (to date, the framework is non-binding and subject to the execution of a binding agreement to be negotiated by the parties) through collaborative out-licensing initiatives.
- On February 13, 2024, the Company announced a strategic partnership with Cygnus Technologies®, part of Maravai LifeSciences®, who have developed the C1 Host Cell Protein ELISA Kit for the quality release of products produced using Dyadic’s protein expression platforms. The C1 Host Cell Protein ELISA Kit is now available for purchase on Cygnus Technologies website under Fungal HCP ELISA kits tab.
- On February 6, 2024, the Company announced it signed a fully funded evaluation agreement including a commercial option with an undisclosed leading global biopharmaceutical company to design and produce recombinant proteins using Dyadic’s C1 microbial protein production platform.
~Animal Health Sector~
- On March 15, 2024, the Company expanded its collaboration with Phibro Animal Health/Abic Biological Laboratories Ltd to develop vaccines and treatments for companion and livestock animal diseases.
- C1 produced adjuvanted recombinant ferritin nanoparticle H5N1 “Bird Flu” human vaccine candidate demonstrated a strong immune response in animal studies for potential use in poultry, cattle and other animals.
- The H5N1 C1 produced bird flu ferritin nanoparticle vaccine elicits high neutralizing antibodies against all three virus isolates (including Texas) of the H5 virus in livestock.
~Alternative Proteins Sector~
Dyadic is advancing a pipeline of differentiated product candidates that leverage its microbial protein production platforms, including Dapibus™ which have demonstrated the ability and efficiency to enable the rapid development and large-scale manufacture of proteins at low cost in a wide range of non-pharmaceutical applications and commercial use.
Cell Culture Media Products - In March 2024, the Company executed a term sheet with a large global albumin manufacturer and distributor to develop and license Dyadic’s recombinant serum albumin. The Company’s animal-free recombinant serum albumin projects were initiated in late 2022 using Dyadic pharmaceutical cell lines for use in potential therapeutic, product development, research, and/or diagnostic human and animal pharmaceutical applications. The Company has completed the initial analysis of its recombinant albumin products and has Certificates of Analysis for recombinant human and bovine albumin that demonstrate comparability to reference standards used in the testing.
- In March 2024, the Company entered into a co-promotion agreement with Biftek Co. for the promotion of growth media supplement for cell culture.
- The Company is undergoing a project to produce recombinant transferrin for use in cell culture media for the alternative protein industry.
- The Company is currently sampling recombinant bovine albumin for application testing as growth media for the cultured meat industry.
Non-animal Dairy Products - As previously announced, in September 2023, the Company entered into a development and exclusive license agreement to commercialize certain non-animal dairy enzymes used in the production of food products using Dapibus™ and received an upfront payment of $0.6 million in October 2023. The Company believes it has achieved the specified target yield level required for a milestone payment upon verification by its partner, and the development of a second enzyme is progressing as planned.
- The Company has developed a highly productive strain and is actively sampling recombinant alpha-lactalbumin, a whey protein, and is currently negotiating several development and commercialization agreements.
- The Company is undergoing a beta-lactoglobulin animal-free recombinant whey protein project, expected to begin sampling in the late third quarter.
- The Company is undergoing a recombinant lactoferrin project, expected to begin sampling the product in the late second or early third quarter.
Bio Industrial Products - The Company has developed three enzymes, with plans for two additional enzymes, that have the potential for use in multiple industries, such as dairy, nutrition, biogas, biofuels and biorefining. Several initial targets are under evaluation with interested parties.
Financial Highlights
Cash Position: As of March 31, 2024, cash, cash equivalents, and the carrying value of investment-grade securities, including accrued interest, were approximately $12.1 million compared to $7.3 million as of December 31, 2023.
Revenue: Research and development revenue and license revenue for the three months ended March 31, 2024, decreased to approximately $335,000 compared to $934,000 for the same period a year ago. The decrease in research and development revenue was due to the winding down of several large research collaborations conducted in 2023. For the three months ended March 31, 2024, the Company’s revenue was generated from ten collaborations compared to seven collaborations in the same period a year ago.
Cost of Revenue: Cost of research and development revenue for the three months ended March 31, 2024, decreased to approximately $144,000 compared to $727,000 for the same period a year ago. The decrease in cost of research and development revenue was due to the same reasons as for revenue described above.
R&D Expenses: Research and development expenses for the three months ended March 31, 2024, decreased by 35.5% to approximately $523,000 compared to $811,000 for the same period a year ago. The decrease reflected the winding down of activities related to the Company’s Phase 1 clinical trial of DYAI-100 COVID-19 vaccine candidate and a decrease in the amount of ongoing internal research projects.
G&A Expenses: General and administrative expenses for the three months ended March 31, 2024, increased by 20.9% to approximately $1,789,000 compared to $1,480,000 for the same period a year ago. The increase reflected increases in business development and investor relations expenses of approximately $138,000, audit fees of $99,000, management incentives of $59,000, and other increases of $59,000, offset by decreases in insurance expenses of $29,000 and legal expenses of $17,000.
Loss from Operations: Loss from operations for the three months ended March 31, 2024, slightly increased to $2,126,000, compared to $2,050,000 for the same period a year ago.
Net Loss: Net loss for the three months ended March 31, 2024, was $2,010,000 or $(0.07) per share compared to $956,000 or $(0.03) per share for the same period a year ago. The increase in net loss was derived from the sale of the Company’s equity interest in Alphazyme LLC for $989,000 in 2023.
Conference Call Information: Date: Tuesday, May 14, 2024 Time: 5:00 p.m. Eastern Time Dial-in numbers: Toll Free 877-407-0784 International +1-201-689-8560 Conference ID: 13743568 Webcast link:
https://viavid.webcasts.com/starthere.jsp?ei=1650831&tp_key=0f89478e24 An archive of the webcast will be available within 24 hours after completion of the live event and will be accessible on the Investor Relations section of the Company’s website at
www.dyadic.com. To access the replay of the webcast, please follow the webcast link above.
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2024.05.15 14:41 albashirco Master Your Day: 3 Morning Habits To Boost Workplace Productivity
I. Introduction Let's face it: mornings can make or break your day.
Ever had one of those days where you hit snooze one too many times, stumble out of bed, and feel like you're already behind before the day even starts?
Yeah, we've all been there. But what if I told you that mastering your mornings could be the key to unlocking your productivity at work? That's right.
In this article, we'll dive into three game-changing morning habits that will supercharge your productivity and set you up for success in the workplace.
II. Rise and Shine: The Importance of Morning Routine There's a reason why successful people like CEOs and entrepreneurs swear by their morning routines—it's because they work. Science backs it up too.
Your morning routine sets the tone for the entire day, influencing your mood, energy levels, and productivity. By establishing a consistent morning routine, you're essentially programming your brain for success.
“Just one small positive thought in the morning can change your whole day.” – Dalai Lama
So, let's rise and shine, shall we? III. Habit 1: Early Rising Picture this: the world is still asleep, the air is crisp, and you have the entire morning to yourself.
That's the beauty of waking up early. Not only does it give you a head start on the day, but it also allows you to tackle your most important tasks when your mind is fresh and distractions are minimal.
But if you're not a morning person (yet), fear not.
With a few simple tweaks to your bedtime routine and some strategic alarm clock placement, you'll be embracing the early bird lifestyle in no time.
IV. Habit 2: Mindful Mindset Ever heard the saying, "mind over matter"? Well, when it comes to productivity, your mindset plays a crucial role. Cultivating a positive mindset in the morning can set the tone for a productive day ahead.
Whether it's practicing gratitude, visualizing success, or simply taking a few deep breaths to center yourself, incorporating mindfulness techniques into your morning routine can work wonders for your productivity and overall well-being.
V. Habit 3: Strategic Planning They say failing to plan is planning to fail, and nowhere is that more true than in the workplace. Taking a few minutes in the morning to map out your day can make all the difference between chaos and control.
Whether it's jotting down your top priorities, time-blocking your schedule, or setting actionable goals, strategic planning ensures that you're focused, organized, and ready to tackle whatever the day throws your way.
“New morning, new moment of miracles.” – Lailah Gifty Akita
VI. Bonus Tips for Supercharging Your Mornings Looking to take your morning routine to the next level?
Here are a few bonus tips to supercharge your mornings and maximize your productivity: - Incorporate exercise: Whether it's a quick jog around the block or a yoga session in your living room, getting your body moving in the morning can boost your energy levels and sharpen your focus.
- Stay hydrated: Start your day off right by drinking a glass of water as soon as you wake up. Hydration is key to staying alert and focused throughout the day.
- Fuel your body: They say breakfast is the most important meal of the day for a reason. Choose nutrient-rich foods that will nourish your body and fuel your brain for optimal performance.
VII. Crafting Your Ideal Morning Routine Now that you have the tools and strategies to transform your mornings, it's time to craft your ideal morning routine.
Remember, there's no one-size-fits-all approach to morning routines. Experiment with different habits and find what works best for you.
Whether it's waking up early, practicing mindfulness, or planning your day with precision, the key is consistency. Stick with it, and watch as your productivity soars to new heights.
VIII. Wrapping Up: Embracing Your Productive Mornings Congratulations! You've taken the first step towards mastering your mornings and boosting your productivity at work.
By implementing these three morning habits—early rising, mindful mindset, and strategic planning—you'll be well on your way to achieving your goals and crushing them in the workplace. So, rise and shine, my friend. Your most productive days are just beginning.
To your success -- M.Albashir FAQs Q: I'm not a morning person. Can I still benefit from these habits? A: Absolutely! While becoming an early riser might take some time and effort, you can still reap the benefits of a mindful mindset and strategic planning at any time of day.
Q: How long does it take to establish a morning routine? A: It varies from person to person, but experts say it takes about 21 days to form a new habit. Be patient with yourself and stay consistent.
Q: What if I have a hectic schedule in the morning? A: Even if you have a busy morning, carving out just a few minutes for each of these habits can make a big difference. Remember, it's about quality, not quantity.
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2024.05.15 14:40 betsharks0 Keep an eye on Auto Insurance, it's currently the cause of nearly half of all annual Supercore inflation:
2024.05.15 14:35 XxSunFlower_88xX Gone far too soon
So this is my first time posting and I think I’m just looking more for a way to write about how I am feeling and get some of these emotions out. I’m not sure how all this works so here we go.
Back in January I started dating this guy ( Let’s call him JW ) anyways things were honestly amazing from the start. I felt like I had found my better half and someone that made me feel complete. He always made me smile and treated me like a Queen. Which honestly was a nice change of pace because I was previously married and my ex-husband was less than kind.
So things moved pretty quick, fast than I anticipated. We even started talking about a future and marriage which I fully realized that we were in the Honeymoon phase. That honestly that kind of when things started to unravel. JW made a comment about us being in the “honeymoon phase “ and I swear it seems like right after that things started to come undone.
So flash forward to a couple weeks later and I happen to come across a bottle of medicine and being Dr. Google over here I searched it up and it came up being for Herpes. So I took a breath and went to him and asked him to explain what is was/ why he had it.
He told me that he had a “scare” 2 years ago with an ex and his doctor put him on it proactively. He said when it came back negative he stopped talking it and he had just forgotten to throw away the bottle. Based on the age of the Rx in my (love sick head) it made sense at the moment.
Flash forward about 2 weeks and we’re at the weekend after Valentines Day 2024. In my mind he did it really well. He was out of town on work ( and no there was 0% chance being out of town was cheating - just FYI )
So he sent me flowers and called and texted he made me feel so loved. No man had ever made me feel so special. Anyways once he got back in town he came over to my house. I had spent literally the whole day making a surprise dinner us . After dinner we exchanged gifts and it was all really sweet.
I could tell something was weighing on his mind and I asked what was up? He said we needed to talk. And I instantly started to worry. I sat beside him and he told me he loved me very much but that he had lied to me. I was like Say What? and he went on to explain that he was ashamed but that when I originally asked if he had Herpes he was embarrassed and didn’t want to say. I was definitely in shock.
A lot of emotions happened from there, I was definitely upset he lied but I also understood where he was coming from. It’s not like you walk up and shake there hand and then be like OHHHH BTW I have Herpes. So I get the nerves, what I was upset about was him lying about it. My ex-husband was a narcissist compulsive liar and that was definitely not something I was going to put up with again.
So where I messed things up got our relationship and looking back now I know that If I ever had the chance to go back and fix things the first thing I would do is NOT Do the following. So after JW told me about the medical condition I was upset, my mind was going at a million miles an hour. He asked that until we figured things out, let’s keep our business, our business.
Well my parents happen to live next door to me and my mom had been calling me wanting to see the necklace that JW got me for Valentine’s Day. So I stepped away and went to show my mom. She could see that I was upset about something and I BLABBED pretty much everything. I did exactly what he asked me not to do. But honestly I was hurt and I really wasn’t thinking about His feelings in that moment. I was reacting.
Looking back now I have definitely learned there is some stuff you keep your business, at least until you figure it out.
So by me telling my mom about his condition she got this mental image of Him that he was somehow a bad person, I believe it was mostly about the lie and him lying in NO Way Ok, he had plenty of opportunities to fess up. Before we ever got intimate in any manner shape or form I asked him are you sure you don’t have anything (std/sti’s) and every time he always said No.
So now that I gave you the introduction to things…
JW and I ended up breaking up, but it wasn’t because we didn’t love each other. I loved his man like Crazy and I was willing to look past the medical condition. In my mind and heart I felt like he was my person . Anyways the reason that we ultimately broke up was my mother. As much as I love here she drives me b@sh1t crazy at times. (We are also a lot alike so we tend to butt heads ) my mom basically gave me an ultimatum that it was her or Him and I couldn’t have both. And seeing as how I’ve always had a close relationship with my parents and I do live next door I ended up caving after almost a week of hard core fighting with my mom and I just couldn’t take it anymore. I broke up with JW.
That was so painful and sickening and I didn’t want to do it but I felt like if I didn’t I would lose my relationship with my mother and possibly even my father, it was too much stress.
Flash forward about a month and I haven’t spoken with JW but I get a message from his mom on FB asking me some questions about him. It was kind of strange but I went with it. I got this ominous feeling like something bad was going on. I asked what happened and she said he had passed away. ****WHAT?!?!?!?!????******
I was just thinking about him last night, I hadn’t stopped thinking about him and or loving him . I was just literally stuck between a rock and a hard(headed mother) . I still snuggle under the blanket every night that smells like him.
So the night before I found out he had passed I actually thought about reaching out. I thought maybe if I give things a little time my mom will cool down. I really wanted everything to play out perfectly. But at the point it was already far too late, he was gone.
JW was only in his late 20s and died from a massive heart attack, it still isn’t real. My heart is so broken and I don’t know what to do or how to deal with all of this.
How do you get over something like this?
I know there are a bunch of different facets to things here but this is what I’ve been living the past couple months.
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2024.05.15 14:35 Zehnpae Darksiders 3 - (The Good, The Bad, The Ugly)
Darksiders 3 is a hack and slash adventure game developed by Gunfire Games. Released in 2018, Darksiders 3 asks the question, "How much more obvious do we have to make it that the developer has an underground BDSM kink?"
We play as Fury, one of the more reasonable members of the Riders of the Apocalypse who have been charged with fixing the ever growing screw up that was the supposed end of the world.
Gameplay is a mix between a hack and slash brawler and souls-lite. Enemies are numerous and swarming but also kill you in two hits if you don't time your dodges just right. Some metroidvania elements exist with backtracking to open up secrets/new areas as you gain new attacks.
The Good
One thing I do loves is when series games acknowledge and call out mistakes they made in the past. In my review of Darksiders 2 I griped about how every single quest comes in 3's. It's always get 3 this, find 3 that, kill 3 this. Early on in DS3 you come across a chamber where you have to gather 3 swords and the protagonist mutters, "It's always 3 isn't it? I hate it when the Creators take shortcuts." I felt seen.
Level design is great. Every area flows into the next and then back again, which I enjoy. I love when games feel like a connected world. Given the variety of environments this is a rather impressive feat. DS3 also features that timeless graphic style popularized by World of Warcraft so even 20 years from now the game will hold up visually.
The Bad
It tries to be a souls-like, hack and slash, metroidvania hybrid and falls a bit short on all accounts. Enemies have fast instant lunge attacks, auto-hit tracking and come in packs of 4+ but you fight like you're in dark souls with narrow dodge windows and animation locking. It's the first game in a long time where I had to set my controller down because I was getting sick of the games bullshit.
You'll pass numerous locations you need items you get later to access, but there's no mapping feature to keep track of this. Remembering the 40+ blocked off locations you passed can be a bit rough so your options are either to backtrack the entire game, use a 100% spoiler guide or just not bother with it.
The Ugly
The controls take awhile to get used to and you can't change them. For some ungodly reason dodge is R1 instead of the B button. Swapping combat forms in battle has a delay and feels very unnatural. Whip swinging often decides to just not work. Trying to select and use a buff item in combat is an exercise in futility.
To compound on that, one nitpicky issue I did have is also many puzzles/levels require you to be in a specific 'stance' or elemental form. Switching between them has a bit of an input delay so if you hit the wrong one you tend to huff as you wait to switch again. If you swap to the wrong form or are doing a puzzle which requires frequent swapping it gets a bit obnoxious.
Final Thoughts
The level layouts are fun and the boss fights are cool. It's when the game tries to marry hack and slash with souls-like that it starts to crack. There's a fine line between difficult and stupid and too often the game leans into stupid territory. As obnoxious as it is, the rest of the game is redeeming enough to make it tolerable. The story is pretty rad, especially if you're a fan of the apocalypse.
Interesting Game Facts
There, of course, is a nude mod. However, far more interesting are the model replacer mods. Eventually I got curious enough to try them out. It's a lot harder to take the end of the world as seriously when you're playing as Fiona from Adventure Time.
Thank you for reading! I'd love to hear your thoughts and experiences with Darksiders 3!
My other reviews on patient gaming
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2024.05.15 14:33 Soccer-Mom-Era Worried 9yr old daughter will be overlooked for ADHD
After the past week I was at my breaking point and turned to google about my daughter. I stumbled upon ADHD. I have gone down the inattentive ADHD rabbit hole the past 24 hours. I have filled out the Vanderbilt parent assessment while I wait for her teachers and soccer coach to do theirs. According to the scoring on the parent form, she doesn’t qualify as ADHD. She is above grade level in school and is in some gifted programs after school. I am worried that might cause her to be overlooked.
We have four kids so I have three kids to compare her to and she is the only one that has these quirks.
•She always loses her glasses or any personal belongings • She very quickly cries about the smallest things (if she is confused, isn’t her turn, can’t find something, plans change or she is tired) •She needs constant supervision to make sure she is getting ready to leave the house •Her room is a disaster. I have spent countless hours teaching her how to pick up and showing her how to pick up her room with no progress. • She needs steps written down to check off to keep her on task of multi step tasks •We call her our daydreamer as she always seems in her own world •I have to constantly remind her of how much time is left before we need to leave or do something. Even still, she waits till the last minute and then panics and says I didn’t give her enough time to get ready.
Here are some issues I didn’t think could be related to ADHD until I started googling
•She prefers to hang out with her younger siblings or young kids in the neighborhood
•She will pick on her siblings relentlessly even after they say no or to stop it. I always wondered if she will be a bully because she seems to seek it out
•She could play with legos or read books for hours on end
•If she gets wound up, she will start bouncing off the walls and will not listen or focus on me when I tell her to calm down. She has to go sit in her room and tell her she is calm.
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2024.05.15 14:32 Blackburncolton32 Input switch PLEASE.
Let me start off by saying I am truly enjoying this game. I can deal with the bugs and issues from it being early access but, devs PLEASE let me change the input over to my desk mounted mic. It auto sets to my headset with which I don’t have the mic anymore. It’s painful to try and communicate in this game without voice chat. When I want to use it I have to set it manually through my pc settings every single time. It’s tiny ease of life things that would make this game a million times more enjoyable.
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2024.05.15 14:31 TN_Runner Playing songs with sample rate > 44.1khz
I have just started moving my library into Apple Music in the hope that it would give a CarPlay experience but I have noticed an interesting technical issue. I have lossless original copies of some of my music (for example, 96khz 24 bit songs ripped from DVD audio included with "deluxe" editions of albums) which I converted to AAC to use with Apple Music, but I didn't do any downsampling so I would have for example 256kbps AAC files that still preserved the 96khz samplerate of the source audio.
I assumed that Apple Music would be able to handle that fine, but when I play any of those songs the output is very distorted. It will be full of pops and crackles and randomly speed up, slow down, or move to the next song prematurely. I am listening with wired headphones on my 2018 Macbook Pro. If I open the same files in Audacity on the same computer and play them they play fine, also if I re-encode from the original .flac files but downsample to 44.1khz during the conversion the new AAC files play fine in Apple Music. So it doesn't seem like there's a problem with the audio files themselves, Apple Music is just not playing them back correctly.
Digging into it a bit, it seems like Apple at some point started selling "hi-res" versions of some songs through their store so there is some discussion about that
here,
here and
here. Thanks to those threads I found out about the "Audio Midi Setup" app which I didn't know about before and I made sure that my headphones were set to 96khz but that did not change anything. Also I learned that apparently you need an external DAC and use "exclusive mode" in order to truly play back at 96khz which was interesting. I assume that when I play these songs in other apps it is not truly 96khz then, and they are downsampling internally, but that raises the question of why isn't Apple Music doing the same thing?
I'm not particularly interested in "bit perfect" playback so I don't mind if my 96khz files get downsampled to 44.1khz at some point on the way to the speakers, I'm just wondering if it's a bug in Apple Music that it doesn't do that automatically when it encounters a 96khz song the way other applications apparently are doing, or if there's a setting somewhere I've accidentally changed which is causing it to choke on these higher samplerate songs.
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2024.05.15 14:31 teamcrazymatt Suspect Dating Game #34 REDUX TIEBREAKER: Mystery of the Seven Keys
Apparently posting the revised poll at 8:15 PM was a bad idea. Only 18 votes were cast and there is a tie at the top.
For those not in the loop, last year I ran a Suspect Dating Game of the series, asking which suspect fans would most like to date. Only three KEY characters had been revealed at the time, so it was a limited poll. Now that we have a game and it's been out for a week, I'm curious as to how the results might change. (This won't affect the bracket as a whole. It may affect the
next poll challenge / game I have planned, which I'll probably drop next month.)
As such I'm leaving the poll open for another day.
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2024.05.15 14:30 kitkid The Possible Collapse of the U.S. Home Insurance System
May 15, 2024
Across the United States, more frequent extreme weather is starting to cause the home insurance market to buckle, even for those who have paid their premiums dutifully year after year.
Christopher Flavelle, a climate reporter, discusses a Times investigation into one of the most consequential effects of the changes.
On today's episode: Christopher Flavelle, a climate change reporter for The New York Times.
Background reading: You can listen to the episode here.
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2024.05.15 14:29 Squippit Hades II Keepsake Tierlist
Keepsake name and effect spoilers only.
S Tier Consistent and good
Knuckle Bones: Fantastic to swap to at the very end, the health chunking is nice, but the main appeal is the damage resist, letting you get more value out of your centaur hearts. Layered defences, yo
Gold Purse: Gives you more freedom over Wells/Turtle Shells and a little extra oomph at pre-boss shop, especially in conjunction with the Boatman arcana
Luckier Tooth: Backup health you can carry in your pocket until you need it. Just in case.
A Tier Heavily impactful, if a bit RNG dependent
Concave Stone: Just a free extra boon, pretty good. Can sometimes land on something you don't want, but usually won't negatively impact you unless you're doing something wierd.
Experimental Hammer: Like above, RNG dependent, and can sometimes cause you to accidentally pivot in a way you really don't want to, but otherwise is a very strong choice to grab before Tartarus or Fields
Transcendent Embryo: Another RNG boon you can pick up for free. Won't negatively impact you ever, but may be useless sometimes.
Aromatic Phial: Free Heroic boon. Better when you have fewer boons that are vital to your build, gets worse as you get a large pool for it to choose from. The extra heal on top is nice though, and can be used once after picking it up mid-run, and once before putting it away
B Tier Not highly impactful in and of themselves, but let you nudge a run in the direction you want
Cloud Bangle, Iridescent Fan, Vivid Sea, Barley Sheaf, Purest Hope, Beautiful Mirror, Adamant Shard, and Everlasting Ember: The main draw of these is simply making a god you want appear. No guarantee you'll get the boon you want, but helpful for forming a build early on and refining one later. They also let you bump a boon up a tier, which can work as a weaker, but more specific Aromatic Phial
Moon Beam: A little more push in whatever direction you want your hex to go, but does not seem to force the Path of Stars to appear sooner.
C Tier Unreliable and poor, but you'll get SOME value out of them
Silver Wheel: Can tide you over until you get a proper means of mana regen, but basekit can usually carry you until then.
Ghost Onion: Worse than a pocket Luckier Tooth Death's Defiance because it only works on changing rooms, and won't help you mid-bossfight. The Wayward Son arcana is a much better version of this if you're just trying to keep topped up between rooms.
Silken Sash: Has some synergies with Arachne's dresses and some Hephestus/Icarus boons, and grants with you some small overshield recharge, but if you're anything like me, you WILL eventually get hit and break it, completely losing the effect.
Crystal Figurine: For the most part, you're already taking all the arcana you want. It's better with Judgement, allowing you take pretty much everything with a pretty low chance of missing your 4th favorite arcana, but Judgement itself seems unnecessary when you can just take the best options to begin with
Evil Eye: The target changes based on who (or what) you're struggling with, but can be a solid damage boost if aimed at the right person.
Lion Fang: A less picky version of Evil Eye, but quickly degrades in strength. Even on the Express Route, you'll still lose 25% bonus damage by the time you reach the boss.
D Tier Niche playstyles, not good for general use
Engraved Pin: You really should be trying not to die, but if you're patient and have good timing, can give you repeated heals throughout the run by balancing on the edge of death. Shame you can't run it alongside the next keepsake.
White Antler: Crit damage is quite good, but the requirement on this one is rather steep. Unless you're doing something wierd, you'll probably want to stay away from this one. You COULD get away with running it while playing normally and just having it usually not be up all the time, but there's largely better options.
Metallic Droplet: Pretty much just for speedruns if you're trying to zoom
Blackened Fleece: Get hit... on purpose? Up to a point, anyways. Probably too tedious to manage your health for this, the damage is a pretty steep cost but the upside is not altogether terrible. If you're not getting hit (You shouldn't be!), won't do anything.
F Tier Actively a hindrance
Discordant Bell: Just don't get hit :)
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