This is not medical advice. I am not suggesting you take these. I am, however, suggesting you perhaps ask your doctor about these supplements and whether it would be okay to take them. You could even present the studies.
Now I can't promise these will be the golden bullet to stop NAFLD or reverse it, but what I can promise is that these supplements are well tolerated, have few side effects when taken as directed, and are generally helpful to very helpful. I don't have NAFLD however I do have genetic liver issues, and have seen positive results from these supplements. I therefore feel like this information is too important not to share. There's also a lot of research backing up weight loss as a result of these supplements, especially NAC - look into it on google scholar, or ask in the comments and i'll provide some.
N-Acetyl L-Cysteine (NAC) is a supplement and medication derived from the amino acid L-cysteine. It acts as a precursor to glutathione, a powerful antioxidant that helps protect cells from damage caused by free radicals and toxins.
It is a well tolerated supplement that shows excellent promise in preventing and treating liver disease, to me it looks to be a miracle supplement as it helps so many conditions.

1. NAC shows an enhanced effect to improve liver function by reducing the levels of oxidative stress and pro-inflammatory markers such as IL-6, TNF-α and IL-1β, NF-κB, TGFβ-1, and MDA levels. This is a review/meta analysis that looks into many studies and found that the results are very promising, even predicting a large increase in demand for NAC because it's so promising.
2. Long-term administration of NAC significantly reduced liver steatosis and triglyceride levels in mice fed a high-fat diet. The researchers suggested that NAC's ability to alleviate endoplasmic reticulum stress and improve fatty acid oxidation contributed to these beneficial effects​
3. NAC treatment in mice leads to a reduction in Liver Fat Accumulation, reduces oxidative stress, improved liver function and concluded it shows potential as a therepeutic agent
4. https://www.sciencedirect.com/science/article/abs/pii/S2213434423000154 - it significantly increased albumin (ALB) and decreased bilirubin levels, a positive change for both measures. The meta analysis suggested larger trials are necessary assessing dose.

Zinc is an essential mineral that plays a crucial role in various biological functions, including those related to liver health

1. Zinc supplementation for three months improved insulin resistance and oxidative stress status in overweight/obese NAFLD patients
2. The Effect of Zinc Supplementation on Steatosis Severity and Liver Function Enzymes in Overweight/Obese Patients with Mild to Moderate Non-alcoholic Fatty Liver Following Calorie-Restricted Diet: a Double-Blind, Randomized Placebo-Controlled Trial

Why I'm posting both together: Zinc acts as a cofactor for a variety of enzymes, including those involved in the metabolism of amino acids like cysteine. For example, the enzyme zinc metalloproteinase relies on zinc to maintain its structural integrity and catalytic function, which can affect the processing of cysteine and related compounds. Zinc is crucial for the storage and secretion of insulin in the pancreas. Insulin contains cysteine residues that form disulfide bonds, essential for its proper structure and function.
Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats. This study doesn't look into liver disease, but it shows remarkable protection against oxidative stress, which is a cause of liver damage.
The combination showed remarkable protection against blood delta-aminolevulinic acid dehydratase (ALAD) activity as well as providing protection to hepatic biochemical variables indicative of oxidative stress
Good luck everyone!

Subject was at 15mg Tirz. Rapidly cross-faded over to Reta, alternating injections. Done with Tirz now, on straight Reta. 5mg every 4 days. May bump up to 5mg every 3 days.
Original weight loss over 18 months was from 248 down to 192. But stalled there for several months. Have now hit 177.
Also had diagnosis of NAFLD. Wanted to get over to Reta based on the study at vcuhealth.org called retatrutide-wiped-out-fat-in-liver-of-obese-patients
Have had few if any side effects all along. Retatrutide doesn't slow digestion as much.

Impact of Cystic Fibrosis on Adults

Cystic Fibrosis (CF) is a genetic disorder that primarily affects the respiratory and digestive systems, but it can also have implications for other parts of the body. With advancements in treatment and care, more people with CF are living into adulthood. However, managing the condition in adults involves dealing with a range of challenges and complications.

Respiratory System

1. Chronic Lung Infections: Adults with CF often experience recurrent lung infections due to thick, sticky mucus that traps bacteria. Common pathogens include Pseudomonas aeruginosa and Staphylococcus aureus.
2. Reduced Lung Function: Over time, repeated infections and inflammation can lead to a decline in lung function, making breathing more difficult.
3. Bronchiectasis: The airways become permanently widened, leading to persistent cough, mucus production, and further infections.
4. Respiratory Failure: In severe cases, lung damage can progress to the point where the lungs cannot provide adequate oxygen to the body, requiring advanced interventions like oxygen therapy or lung transplantation.

Digestive System

1. Pancreatic Insufficiency: Thick mucus can block the ducts of the pancreas, preventing digestive enzymes from reaching the intestines. This leads to malabsorption of nutrients, malnutrition, and vitamin deficiencies.
2. Diabetes: CF-related diabetes (CFRD) is common in adults due to the damage to the pancreas. It shares characteristics of both Type 1 and Type 2 diabetes.
3. Liver Disease: Blockages in the bile ducts can lead to liver damage, cirrhosis, and portal hypertension.
4. Intestinal Issues: CF can cause intestinal blockages, gastroesophageal reflux disease (GERD), and distal intestinal obstructive syndrome (DIOS).

Reproductive System

1. Infertility: Most men with CF are infertile due to congenital absence of the vas deferens, which carries sperm from the testes. However, assisted reproductive technologies can help achieve pregnancy.
2. Reduced Fertility in Women: Thick cervical mucus can make it harder for sperm to reach the egg, but many women with CF can still conceive naturally or with assistance.

Musculoskeletal System

1. Osteoporosis: Due to malabsorption of calcium and vitamin D, adults with CF are at higher risk for osteoporosis and fractures.
2. Arthritis: Some adults may develop CF-related arthritis or musculoskeletal pain.

Psychosocial Impact

1. Mental Health: The chronic nature of CF can lead to anxiety, depression, and stress. The need for continuous treatment and hospitalizations can impact quality of life.
2. Social and Work Life: Managing CF often requires time-consuming treatments and frequent medical appointments, which can interfere with work and social activities.

Treatment and Management

1. Medications:

• Bronchodilators: To open the airways.
• Mucolytics: To thin mucus.
• Antibiotics: To treat and prevent infections.
• Pancreatic Enzymes: To aid digestion.
• CFTR Modulators: Target the defective protein in CF and improve its function.

1. Airway Clearance Techniques: Daily physiotherapy to clear mucus from the lungs.
2. Nutritional Support: High-calorie diet, vitamin supplements, and enzyme replacements.
3. Exercise: Regular physical activity to maintain lung function and overall health.
4. Psychological Support: Counseling or therapy to help manage the emotional aspects of living with CF.
5. Advanced Therapies: Lung transplantation may be an option for those with severe lung disease.

Conclusion

While cystic fibrosis poses significant challenges for adults, ongoing advancements in medical care and treatment strategies are helping many individuals manage their condition more effectively and lead fuller lives. Comprehensive, multidisciplinary care is essential to address the complex needs of adults with CF, including respiratory, digestive, reproductive, and psychosocial aspects. Regular follow-up with healthcare providers specialized in CF care is crucial for optimizing health outcomes and maintaining quality of life.
Blaze0 notes Impact of Cystic Fibrosis on Adults
Cystic Fibrosis (CF) is a genetic disorder that primarily affects the respiratory and digestive systems, but it can also have implications for other parts of the body. With advancements in treatment and care, more people with CF are living into adulthood. However, managing the condition in adults involves dealing with a range of challenges and complications.

Respiratory System

1. Chronic Lung Infections: Adults with CF often experience recurrent lung infections due to thick, sticky mucus that traps bacteria. Common pathogens include Pseudomonas aeruginosa and Staphylococcus aureus.
2. Reduced Lung Function: Over time, repeated infections and inflammation can lead to a decline in lung function, making breathing more difficult.
3. Bronchiectasis: The airways become permanently widened, leading to persistent cough, mucus production, and further infections.
4. Respiratory Failure: In severe cases, lung damage can progress to the point where the lungs cannot provide adequate oxygen to the body, requiring advanced interventions like oxygen therapy or lung transplantation.

Digestive System

1. Pancreatic Insufficiency: Thick mucus can block the ducts of the pancreas, preventing digestive enzymes from reaching the intestines. This leads to malabsorption of nutrients, malnutrition, and vitamin deficiencies.
2. Diabetes: CF-related diabetes (CFRD) is common in adults due to the damage to the pancreas. It shares characteristics of both Type 1 and Type 2 diabetes.
3. Liver Disease: Blockages in the bile ducts can lead to liver damage, cirrhosis, and portal hypertension.
4. Intestinal Issues: CF can cause intestinal blockages, gastroesophageal reflux disease (GERD), and distal intestinal obstructive syndrome (DIOS).

Reproductive System

1. Infertility: Most men with CF are infertile due to congenital absence of the vas deferens, which carries sperm from the testes. However, assisted reproductive technologies can help achieve pregnancy.
2. Reduced Fertility in Women: Thick cervical mucus can make it harder for sperm to reach the egg, but many women with CF can still conceive naturally or with assistance.

Musculoskeletal System

1. Osteoporosis: Due to malabsorption of calcium and vitamin D, adults with CF are at higher risk for osteoporosis and fractures.
2. Arthritis: Some adults may develop CF-related arthritis or musculoskeletal pain.

Psychosocial Impact

1. Mental Health: The chronic nature of CF can lead to anxiety, depression, and stress. The need for continuous treatment and hospitalizations can impact quality of life.
2. Social and Work Life: Managing CF often requires time-consuming treatments and frequent medical appointments, which can interfere with work and social activities.

Treatment and Management

1. Medications:

• Bronchodilators: To open the airways.
• Mucolytics: To thin mucus.
• Antibiotics: To treat and prevent infections.
• Pancreatic Enzymes: To aid digestion.
• CFTR Modulators: Target the defective protein in CF and improve its function.

1. Airway Clearance Techniques: Daily physiotherapy to clear mucus from the lungs.
2. Nutritional Support: High-calorie diet, vitamin supplements, and enzyme replacements.
3. Exercise: Regular physical activity to maintain lung function and overall health.
4. Psychological Support: Counseling or therapy to help manage the emotional aspects of living with CF.
5. Advanced Therapies: Lung transplantation may be an option for those with severe lung disease.

Conclusion

While cystic fibrosis poses significant challenges for adults, ongoing advancements in medical care and treatment strategies are helping many individuals manage their condition more effectively and lead fuller lives. Comprehensive, multidisciplinary care is essential to address the complex needs of adults with CF, including respiratory, digestive, reproductive, and psychosocial aspects. Regular follow-up with healthcare providers specialized in CF care is crucial for optimizing health outcomes and maintaining quality of life.

Have you ever wondered what the main problems that patients or suspected TB patients face?
👉 Hard to detect the disease: The initial symptoms of Tuberculosis (TB) are often nonspecific, which may include cough, chest pain, and shortness of breath, leading to confusion with normal diseases such as flu or pneumonia. Moreover, the traditional TB diagnostic process can take up to 2-3 weeks.
👉 The treatment process is prolonged: Treating Tuberculosis (TB) typically requires an average duration of 6 months to a year, depending on the patient's underlying health and response to therapy. This constitutes a challenging journey that demands patience and determination from the patient, along with support from family and healthcare professionals.
👉 Health deterioration: In addition to prolonged and persistent coughing, the treatment process for Tuberculosis (TB) also impacts overall health. Anti-TB medications often come with side effects such as nausea, fatigue, headaches, and most critically, potential damage to the liver and kidneys.
👉 Quarantine fear: Concerns about infection transmission and insufficient understanding of Tuberculosis (TB) can lead to social isolation, resulting in mental stress and negative impacts on treatment adherence.

Discover the power of natural remedies for detoxifying your liver and kidneys on Fitness Freak! Explore effective methods to cleanse your body, boost energy, and enhance overall well-being. Dive into this essential guide today for expert insights and practical tips to rejuvenate your health naturally!

Discover the power of natural remedies for detoxifying your liver and kidneys on Fitness Freak! Explore effective methods to cleanse your body, boost energy, and enhance overall well-being. Dive into this essential guide today for expert insights and practical tips to rejuvenate your health naturally! Read more https://fitness-freak.co/do-home-remedies-really-work-to-detox-liver-and-kidney-an-overall-guide/

Originating from Nigeria, Fadogia agrestis has emerged as a subject of interest, particularly for its purported aphrodisiac properties. Animal studies have illuminated its potential to elevate testosterone levels and augment libido, along with enhancing testicular weight, hinting at its potential as a sexual performance enhancer.
Benefits of Fadogia Agrestis
Drawing from rodent studies and anecdotal reports, Fadogia agrestis showcases several notable benefits:

• Increased Testosterone Levels: Rodent trials indicate a notable surge in testosterone levels with Fadogia agrestis supplementation, showing dose-dependent increments.
• Enhanced Libido and Sexual Function: Traditional aphrodisiac use aligns with scientific findings, showcasing its pro-erectile and libido-boosting effects.
• Improved Energy and Recovery: Users often report heightened energy levels, decreased fatigue, and swifter exercise recuperation.
• Potential Anti-Inflammatory and Anti-Malarial Effects: Preliminary in vitro studies suggest its inhibitory impact on parasites, bacteria, and mild anti-malarial properties.

However, it's imperative to acknowledge the scarcity of human clinical trials regarding Fadogia agrestis benefits. Present evidence primarily stems from rodent studies and user anecdotes, necessitating further exploration to delineate its efficacy and safety in humans.
Dosage Recommendations
Tailoring the dosage to individual factors like age, weight, and health objectives is paramount. Starting with a lower dosage mitigates potential side effects, with general recommendations falling within 200-600 mg per day, divided into doses. Seeking guidance from healthcare professionals before integrating Fadogia agrestis into a supplement regimen is prudent.
Potential Side Effects
Navigating potential side effects underscores the importance of consulting healthcare professionals:

• Gastrointestinal Discomfort: Common complaints include stomach upset, bloating, and diarrhea.
• Allergic Reactions: Mild skin rashes to severe symptoms like difficulty breathing may occur.
• Hormonal Imbalances: Impact on testosterone levels may induce hormonal fluctuations.
• Sleep and Psychological Effects: Altered sleep patterns, anxiety, and restlessness may manifest.
• Liver and Kidney Concerns: Prolonged high doses may provoke inflammation and damage.
• Other Reported Side Effects: Nausea may accompany Fadogia agrestis usage.

Conclusion
While Fadogia agrestis presents intriguing potential benefits such as libido enhancement and testosterone elevation in animal studies, a cautious approach is warranted. Further research is indispensable to elucidate its effects comprehensively and ensure safety. Prioritizing evidence-based practices and seeking professional guidance facilitate informed health decisions, promoting holistic well-being.
📋 Source: Fadogia Agrestis: Benefits, Dosage & Side effects

Long story short, I've been diagnosed with CF, but what would be considered a very mild form. (A single F508 mutation and a Poly 5T mutation, which i think is a CFTR related gene or something) It seems to be quite rare, but they've classified it as CF now because I a medium-abnormal level sweat test (forget the range), infertile due to lack of vas deferens, and a history of common chest infections/walking pnuemonia, etc.
First, i'm curious, of other people who have atypical forms of this disease, has it gotten worse as you get older? My doc says it can stay really mild in some, get worse in others, but it's tough because my combination is apparently really rare.
My doc wants to try me on Trikafta, and i've been a bit nervous. Partially because it feels like overkill sometimes, as most of my doctor's patients are not 'mild' cases, and there's a number of concerning side effects form what i've been reading about. Also i do like to have a drink - probably have a drink or two a night usually. I was told i'd need to cut that way back, a drink or two a week, which admittedly i'm totally fine with, butt I'm unclear on if i can still have a party night here or there. Like, if i have a four or five drinks from 6pm to 12am, am i gonna go to the hospital? I know my liver tests they've done come back normal.

Male
17 years
Long hair tabby/main coon mix
Wisconsin
After effects from anesthesia not wearing off
It's been 60 hours
Stumbling, vision seems off, walking in circles one direction, left side weak
Last week I took out cat into vet because he was due for a vaccine, and mentioned that I noticed he felt thinner. We discovered that he lost 3lbs in the last year, which is alarming. He also slept alot more, but being an older cat, that's pretty normal. Otherwise he was still our same loving boy. Always coming to sit by us, give kisses, purr and even play a bit yet.
We did a blood sample and found out he had early stages of kidney failure, which isn't super surprising for his age. But also that vet didn't think that alone would have attributed to this much weight loss. It was suggested to go an ultrasound to see if he had any inflammation in his intestines that would cause him to not want to eat. In this case we could treat with steroids for a while. Also we were looking for any other concerns like a tumor. We strongly debated not bringing him in because it causes him so much stress to go to vet, and we considered just starting him on steroids to see if it would help. If indeed he had a mass or cancer we would not put him through any surgery or treatment at his age of 17 either way.
After that first visit to the vet, he almost stopped eating. Was it due to stress? We had had the ultrasound scheduled for the following week. We were not sure we could wait that long, , and we were worried so vet was able to get him in earlier. I was second guessing this decision because the stress it causes him, but we reluctantly decided to just bring him in for scans. At least then we would have answered and know what we can do for him.
We did discover that he has a liver mass and inflammation. So we're doing steroids for that, and otherwise the plan was to just monitor him close, knowing that we would appreciate the time we had.
The big problem now is, he must have had a bad reaction to being sedated. Upon brining him home he was unstable and falling down, boy i was not that concerned being that he still had anesthesia in his body. It was the second day it got much worse. He is weak on his left side, occasionally falls and bumps into things and only pretty much walks in clockwise circles. It seems like he can't see well and when he sleeps, he sleeps upright with his head turned to one side. Both his left legs are not working right. He's still eating and drinking ok and purrs occasionally, but we're going on over 60 hours from anesthesia and he's still not back to himself. We're unsure of how this will go. We're still hoping that he will improves from this. His other concerns were there, and we planned to manage them, but this new problem of being unstable is the hard part. We can't help but feel guilty that we put him through that.
Has anyone had this experience? I know my cat has alot working against him right now. But if he was still able to move around like me was just a few days ago, I know we would still have some time left with him. Will this wear off? We are so upset that this happened and strongly regret taking him in for his scan. Given his current state, I do not think we would stress him out and take him to the vet. I'm just looking to see if anyone has experienced this and if there is hope he will return to normal mobility.

Any good literature or studies about these side effects? Only things the studies mention are potential stomach issues, or some rare Liver or thyroid interactions? But there are a lot of anecdotes about it causing depression, worsening anxiety, suicidal thoughts, ruining people's lives, etc.
Curious on your thoughts.

Ok the police report came in today. No autopsy report was included. But the gist was Dave was drunk at the baseball game the night before and a friend drove him home. He spoke to Heidi and they were broken up. His friend amd the nanny, said he was upset about the breakup because he missed Heidi’s son’s 18th birthday. Rachel said he was drunk at the game and would leave and come ba k, perhaps doing drugs. The friend, the nanny, and rach all said they suspected he was doing cocaine. He was also on several testosterone meds for body building. He had gained a large amount of bulk recently and had went to the hospital in January for heart issues. The report states he had an enraged heart, restricted blood vessels, low testosterone, and fatty liver disease. He was very heavily intoxicated and several containers of mikes hard lemonades were found throughout his home.
None of this came as a shock to me as a mild reader here so I’m not sure what plot twist this woman is talking about.
Heidi was on the phone with the nanny when she (nanny) found him unresponsive w, gasped and hung up to call 911.
Edit to add: Oh crap at the very bottom it states the results of the autopsy being cause of death: toxic effects of cocaine, ethanol, and fentanyl.

Regularly we receive questions about Dr. Clark Parasite Cleanse and the possible symptoms of the parasites being flushed out of the body. These symptoms occur because parasites can harbor bacteria and viruses that are released when the parasites are eliminated. Not everyone is the same and symptoms can vary from person to person.
Pre-Cleanse Measures: To minimize detoxification reactions, it is advisable to start with Dr. Clark’s Bowel Cleanse. This initial step not only helps in getting rid of parasites and bacteria but also clears out toxins from the intestines, setting a cleaner stage for the subsequent parasite cleanse.
Common Detox Symptoms and Solutions for Dr. Clark’s Parasite Cleanse:

• Flu-like symptoms (chills, fever, cough):
  • Cause: Release of the flu virus.
  • Remedies: Elder tea to boost the immune system and Oscillococcinum, a homeopathic remedy (1 dose in the morning, 1 at night).
• Nausea, diarrhea, fever, digestive issues:
  • Cause: Release of bacteria like Salmonella.
  • Remedies: Lugol's iodine (ensure no allergy to iodine). Recommended dosage is 6 drops in water, six times a day, preferably on an empty stomach.
• Emotional distress (sadness, melancholy, crying):
  • Cause: Release of Clostridium botulinum affecting the hypothalamus.

Remedies: Oregano oil, 5-10 drops in an empty capsule taken with 1 or 2 meals.
To better symptoms and support the body during Dr. Clark’s Parasite Cleanse, do the following:

• Stay Hydrated: Drinking plenty of water helps flush toxins out of the body. Aim for at least 8-10 glasses daily.
• Balanced Diet: Eating a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can provide the necessary nutrients to support detoxification.
• Rest and Sleep: Ensure you get adequate rest; the body heals and detoxifies most efficiently while you're asleep.
• Gentle Exercise: Activities like walking, yoga, and light stretching can enhance circulation and help in managing stress.
• Activated Charcoal: This can be used to absorb toxins and help reduce symptoms like nausea or gas. Always consult a healthcare provider before using it as it can interfere with medication absorption.
• Herbal Support: Milk thistle, dandelion root, and turmeric can support liver function, a key organ in the detoxification process.

Prepare for cleansing and follow the suggested steps to make your cleansing process as comfortable and effective as possible. 🌊🪱🌊

CAPR reported a significant revenue growth of 64.3% reaching $4.907 million in Q1 2024, but faced high operating expenses and a negative EPS of -$0.31.

Key Metrics

Revenue	$4.907M	64.3%
Operating Expenses	$15.173M
	Operating Expenses Growth	35.9%
	Earnings Per Share	$-0.31
Cash and Cash Equivalents	$39.917M

Business Highlights

• Enrollment has been completed for our HOPE-3 Phase 3 (Cohort A) clinical trial which enrolled 61 subjects randomized to either CAP-1002 or placebo in a 1:1 ratio.
• Reported a positive outcome from the interim futility analysis for Cohort A which triggered the first milestone payment of $10.0 million received in the first quarter of 2024 under our U.S. Distribution and Commercialization Agreement with Nippon Shinyaku.
• Reported a positive outcome from the interim futility analysis for Cohort A which triggered the first milestone payment of $10.0 million received in the first quarter of 2024 under our U.S. Distribution and Commercialization Agreement with Nippon Shinyaku.
• Announced a positive outcome from a Type-B CMC FDA meeting held in the first quarter of 2024. In the meeting, the FDA affirmed alignment on the following topics: Comparability between drug product manufactured at our two different facilities (Los Angeles and San Diego) has been demonstrated using the provided analytical comparability data. This will now allow for the use of CAP-1002 drug product manufactured at our San Diego manufacturing facility upon potential product approval (subject to approval of the facility).
• Granted a Type-B clinical FDA meeting scheduled to be held in May 2024 to continue discussing our pathway to BLA. The FDA advised us to include discussion and a request for a pre-BLA meeting and rolling BLA schedule at this meeting. We also plan to share with FDA our HOPE-2 OLE 3-year safety and efficacy data.
• Announced further specifics under our U.S. Distribution and Commercialization Agreement with Nippon Shinyaku. Capricor will receive a meaningful mid-range double-digit share of product revenue. For clarity, mid-range falls in between 30-50%, which sum will be offset by the amounts paid to us as the transfer price for the purchase of the product. As previously disclosed, there is an additional $90.0 million in potential milestone payments up to the time of approval which are triggered upon certain regulatory-based achievements. Following potential approval, there is an additional $605.0 million in potential milestones payments which may be payable to Capricor based on various sales-based targets being met.
• Announced we are on track to enroll 44 U.S. based patients by the end of second quarter in HOPE-3 (Cohort B) clinical trial, however at this time, we are evaluating various options, with one of such options being the opportunity for an expansion of Cohort B to include European patients.
• Announced the scale-up of manufacturing capacity of CAP-1002 in our new San Diego facility, intended for commercial use, subject to regulatory approval. This facility was designed to be a versatile and cost-effective way to bring CAP-1002 to market efficiently. Currently, our San Diego facility is fully operational, staffed and producing doses for clinical use. Along with BLA readiness activities, we are also actively preparing for commercial runs.
• Presented at H.C. Wainwright 2ndAnnual Cell Therapy Conference.
• Presented at the Cantor Fitzgerald’s Muscular Dystrophy Symposium.
• Presented at the2024 Muscular Dystrophy Association (MDA) Clinical & Scientific Conferencesharing the previously presented positive 24-month results from our HOPE-2 OLE study. Key results included skeletal muscle function as measured by the Performance of the Upper Limb (PUL v2.0) showed a mean PUL v2.0 decline after 24-months of treatment with CAP-1002 was 2.8 points versus a 7.7 point decline on average observed over 24-months in the placebo patient group. Additionally, CAP-1002 revealed clinically meaningful improvements in ameliorating cardiac function
• Presented at theParent Project Muscular Dystrophy (PPMD) Cardiac Workshop III. Capricor was featured in a panel on industry perspectives on cardiac monitoring in DMD clinical trials.
• Announced that our proprietary StealthX™ exosome-based multivalent vaccine (StealthX™ vaccine) for the prevention of SARS-CoV-2 was selected to be part ofProject NextGen, an initiative by the U.S. Department of Health and Human Services to advance a pipeline of new, innovative vaccines. As part of Project NextGen, NIAID, part of the National Institutes of Health, will conduct and fund a Phase 1 clinical trial with our StealthX™ vaccine. Under the terms of the collaboration, Capricor will supply the investigational product and NIAID's Division of Microbiology and Infectious Diseases (DMID) will conduct the trial. If NIAID finds that our StealthX™ vaccine meets its criteria for safety and efficacy, they may consider our program for a funded Phase 2.
• Currently, in collaboration with an undisclosed pharmaceutical company, we are also investigating the therapeutic application of our StealthX™ exosome platform.
• Presented data in an oral presentation at theAmerican Society of Gene and Cell Therapy (ASGCT) 27thAnnual Meeting. The findings highlight a potential exosome-based approach for the treatment of arginase-1 deficiency (ARG1-D), a rare genetic metabolic disease characterized by complete or partial lack of the enzyme arginase in the liver and red blood cells. The data from this preclinical study further characterize our StealthX™ exosome platform.
• Presented data at theInternational Society of Extracellular Vesicles (ISEV) Annual Meeting 2024. Highlights from the abstract included data showing targeted cargo delivery to mouse lower limbs by exosomes carrying a muscle targeting moiety by intravenous injection.

Guidance
Future Business Drivers: - Plan to have a Type-B clinical FDA meeting in May 2024 to discuss requests for a pre-BLA meeting and rolling BLA schedule. Additionally, Capricor plans to share with FDA its HOPE-2 OLE 3-year safety and efficacy data at this meeting. - Plan to report 3-year HOPE-2 OLE data in the second quarter of 2024. - Plan to announce further updates with respect to next steps for HOPE-3 (Cohort B), when available. - Plan to report topline data from HOPE-3 (Cohort A) in the fourth quarter of 2024. - Continue to explore opportunities for additional partnerships outside of the U.S. and Japan to support the potential commercialization of CAP-1002 in DMD. - Plan to provide updates on our NIAID collaboration for our StealthX™ vaccine as they become available. NIAID plans to initiate the Phase 1 clinical trial in late 2024, subject to regulatory approval. - Continue to explore opportunities for partnerships and non-dilutive sources of funding to support advancement of our StealthX™ exosome platform technology.
Expectations: MISS
While CAPR's revenue of $4.907 million in Q1 2024 surpassed the average analyst estimate of $9.7 million, the EPS of -$0.31 was significantly worse than the estimated -$0.11. The company's operating expenses grew by 35.9% to $15.173 million, contributing to the negative earnings per share.

In a world where health and wellness are paramount, it's no surprise that people are turning to natural remedies to support their well-being. One such remedy gaining popularity is Chaga tea – a powerful elixir brewed from the nutrient-rich Chaga mushroom. In this blog post, we'll explore the numerous benefits of drinking Chaga tea and why it's becoming a staple in the wellness routines of many.

What is Chaga Tea?

Chaga tea is made from the Chaga mushroom (Inonotus obliquus), a fungus that grows on birch trees in cold climates, particularly in Siberia, Russia, and parts of North America. Revered for centuries in traditional medicine systems like Russian folk medicine and Chinese herbalism, Chaga mushrooms are packed with beneficial compounds that offer a host of health benefits.

The Benefits of Drinking Chaga Tea

1. Immune Support

Chaga tea is rich in antioxidants, including polysaccharides, polyphenols, and beta-glucans, which help strengthen the immune system and protect the body against infections and illnesses. By boosting the immune response, Chaga tea can help ward off colds, flu, and other common ailments, keeping you feeling healthy and vibrant year-round.

2. Anti-Inflammatory Properties

Chaga tea contains potent anti-inflammatory compounds, such as betulinic acid and triterpenes, which help reduce inflammation in the body. Regular consumption of Chaga tea may help alleviate symptoms of inflammatory conditions like arthritis, joint pain, and gastrointestinal disorders, promoting overall comfort and well-being.

3. Antioxidant Protection

Antioxidants play a crucial role in neutralizing harmful free radicals in the body, thereby protecting against oxidative stress and cellular damage. Chaga tea is loaded with antioxidants, making it an excellent choice for promoting skin health, slowing down the aging process, and reducing the risk of chronic diseases like cancer and heart disease.

4. Energy and Vitality

Unlike caffeinated beverages that provide a temporary energy boost followed by a crash, Chaga tea offers sustained energy and vitality without the jitters or caffeine-related side effects. Thanks to its adaptogenic properties, Chaga tea helps support adrenal health, balance stress hormones, and promote overall energy levels, keeping you feeling alert and focused throughout the day.

5. Digestive Health

Chaga tea contains soluble fiber, polysaccharides, and prebiotics that support digestive health by promoting a healthy gut microbiome, improving digestion, and alleviating gastrointestinal issues like bloating, constipation, and indigestion. Regular consumption of Chaga tea can help maintain a healthy digestive system and enhance nutrient absorption.

6. Liver Support

The liver plays a vital role in detoxification and metabolic processes in the body. Chaga tea contains compounds that support liver health and function, including enzymes that aid in detoxification and antioxidants that protect liver cells from damage. Incorporating Chaga tea into your wellness routine can help support overall liver health and promote optimal detoxification.

How to Enjoy Chaga Tea

Brewing Chaga tea is simple and straightforward. Start by obtaining high-quality Chaga mushroom pieces or Chaga tea bags from a reputable source. Then, steep the Chaga pieces or tea bags in hot water for at least 15-20 minutes to extract the beneficial compounds. You can enjoy Chaga tea hot or cold, plain or with added flavors like honey, lemon, or spices.

Conclusion

In conclusion, Chaga tea is a nourishing and therapeutic beverage that offers a myriad of health benefits for both body and mind. From immune support and anti-inflammatory properties to antioxidant protection and digestive health, Chaga tea is a true superfood elixir that can enhance your overall well-being. Whether you're looking to boost your immune system, reduce inflammation, or simply enjoy a soothing cup of tea, Chaga tea is a delicious and convenient way to support your health naturally. Embrace the power of Chaga tea and experience the transformative benefits for yourself!
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Liv Pure For Weight Loss
Liv Pure has emerged as a central hub for those seeking insights into the effectiveness of this liver health supplement. This thorough review delves into its composition, advantages, and customer opinions, providing a comprehensive view for potential users.

Who Developed the Liv Pure Formula

The formulation of Liv Pure was orchestrated by a team of specialists in the realm of liver health and nutrition. Their combined knowledge and commitment to scientific inquiry resulted in a potent amalgamation of natural components aimed at bolstering liver function and overall health.

What is Liv Pure

Liv Pure presents a detailed examination of a liver health supplement crafted to facilitate detoxification and weight loss. It serves as a valuable guide for individuals aiming to make well-informed choices about their health and explore natural remedies for liver support.

How Does Liv Pure Operate?

Liv Pure elucidates the mechanism underpinning the supplement's effectiveness, shedding light on how its components collaborate to enhance liver function, accelerate metabolism, and aid in fat burning. This analysis offers clarity on the supplement's role in fostering overall health and wellness.

Pros

• Natural Components: Liv Pure comprises a blend of natural elements, devoid of artificial additives.
• Liver Support: The supplement is designed to bolster optimal liver function and detoxification.
• Weight Loss Assistance: Liv Pure assists in boosting metabolism and promoting healthy weight loss.
• Positive Customer Feedback: Numerous users have shared favorable experiences with Liv Pure .
• Trusted Formulation: Liv Pure is underpinned by scientific research and formulated by experts in the field.

Cons

• Availability: Liv Pure may solely be accessible for purchase online, potentially limiting access for some individuals.
• Individual Variability: While many users observe positive results, responses to Liv Pure may differ among individuals.
• Unsuitable for Pregnant or Nursing Women: Due to its potent formula, Liv Pure is not recommended for pregnant or nursing women.
• Potential Side Effects: Some users may encounter minor side effects such as gastrointestinal discomfort.
• Cost: The price of Liv Pure may serve as a deterrent for certain prospective users.

Ingredients

• Milk Thistle: Supports liver health and detoxification processes.
• Artichoke Extract: Assists in digestion and promotes liver function.
• Turmeric: Possesses anti-inflammatory properties and supports liver health.
• Dandelion Root: Facilitates liver detoxification and promotes bile production.
• Beetroot Extract: Abounds in antioxidants and supports liver function.

Benefits

• Liver Support: Liv Pure aids in detoxification and sustains optimal liver function.
• Weight Management: The supplement aids in metabolism and fat burning, fostering healthy weight loss.
• Energy Boost: Liv Pure elevates energy levels, promoting vitality and overall well-being.

Key Features

• Natural Composition: Liv Pure is crafted with natural ingredients, ensuring safety and efficacy.
• Scientific Validation: The supplement's composition is substantiated by scientific research and clinical studies.
• Quality Assurance: Liv Pure is manufactured in FDA-approved facilities, adhering to stringent quality standards.

Why Opt for Liv Pure

Liv Pure distinguishes itself as a dependable source of information for individuals aspiring to enhance liver health and promote weight loss naturally. Its thorough analysis furnishes valuable insights into the supplement's effectiveness and customer satisfaction.

Health Benefits

• Liver Support: Liv Pure aids in detoxification, fostering optimal liver function and overall health.
• Weight Management: The supplement supports metabolism and fat burning, facilitating healthy weight loss.
• Digestive Support: Liv Pure promotes digestive health, aiding in nutrient absorption and digestion.

Side Effects

Although Liv Pure is generally safe for most users, some individuals may experience minor side effects such as gastrointestinal discomfort. It is advisable to consult with a healthcare professional before commencing any new supplement regimen.

Pricing Structure

• 30-Day Supply: $69 per bottle
• 90-Day Supply: $49 per bottle
• 180-Day Supply: $39 per bottle

Refund Policy

Liv Pure extends a 60-day money-back guarantee on all purchases, enabling customers to trial the product risk-free.

FAQs

How should I consume Liv Pure?

• The recommended dosage of Liv Pure is [insert dosage instructions here]. It is advisable to consult with a healthcare professional before commencing any new supplement regimen.

Are there any allergens in Liv Pure?

• Liv Pure is formulated with natural ingredients and is free from common allergens such as [insert allergens here]. However, individuals with specific allergies should meticulously review the ingredient list before consumption.

Can I take Liv Pur alongside existing medical conditions?

• Individuals with pre-existing medical conditions should consult with a healthcare professional before taking Liv Pure to ascertain compatibility with their current treatment plans.

Is Liv Pure suitable for vegetarians/vegans?

• Yes, Liv Pure is suitable for vegetarians/vegans as it does not contain any animal-derived ingredients.

Final Thoughts

In summary, Liv Pure furnishes a comprehensive overview of a liver health supplement tailored to promote detoxification and weight loss. Through its detailed analysis and customer testimonials, Liv Pure serves as an invaluable resource for individuals seeking to optimize their liver health naturally.

Glutathione, often referred to as the body's "master antioxidant," plays a critical role in maintaining overall health and well-being. However, when levels of glutathione become depleted, adverse consequences can arise, impacting various aspects of health. In this article, we'll explore the detrimental effects of glutathione deficiency on the body and the importance of addressing this deficiency to promote optimal health.
**1. Increased Oxidative Stress*\*
Glutathione is a potent antioxidant that helps neutralize free radicals and protect cells from oxidative damage. When glutathione levels are insufficient, the body becomes more susceptible to oxidative stress, leading to cellular damage and accelerated aging. Increased oxidative stress has been linked to a wide range of health issues, including chronic inflammation, cardiovascular disease, and neurodegenerative disorders.
**2. Weakened Immune Function*\*
Adequate glutathione levels are essential for maintaining a robust immune system. Glutathione plays a vital role in supporting immune function by enhancing the activity of immune cells and helping to regulate inflammation. When glutathione levels are low, the immune system may become compromised, increasing the risk of infections, autoimmune conditions, and other immune-related disorders.
**3. Impaired Detoxification*\*
Glutathione is involved in the detoxification process, helping to remove harmful toxins and pollutants from the body. As a potent antioxidant, glutathione neutralizes toxins and facilitates their elimination through the liver and kidneys. A deficiency in glutathione can impair the body's ability to detoxify effectively, leading to toxin buildup and an increased risk of toxin-related health issues, such as liver damage and oxidative stress-induced cell damage.
**4. Reduced Energy Production*\*
Glutathione plays a crucial role in energy metabolism, particularly within the mitochondria, the powerhouse of the cell. Low glutathione levels can impair mitochondrial function, resulting in reduced energy production and cellular dysfunction. As a consequence, individuals with glutathione deficiency may experience fatigue, lethargy, and a general lack of energy, negatively impacting their overall quality of life.
**5. Accelerated Aging*\*
Oxidative stress, immune dysfunction, impaired detoxification, and reduced energy production – all consequences of glutathione deficiency – contribute to accelerated aging at the cellular level. Chronic glutathione deficiency has been associated with premature aging, characterized by wrinkles, fine lines, sagging skin, and other signs of aging. By addressing glutathione deficiency, individuals may be able to slow down the aging process and maintain a youthful appearance.
**Conclusion: Addressing Glutathione Deficiency for Optimal Health**
In conclusion, glutathione deficiency can have far-reaching consequences for health and well-being, affecting various physiological processes and increasing the risk of chronic diseases. It is essential to recognize the importance of maintaining adequate glutathione levels and take proactive steps to address deficiency through dietary changes, lifestyle modifications, and targeted supplementation.
By supporting glutathione levels, individuals can mitigate the adverse effects of oxidative stress, strengthen immune function, enhance detoxification, boost energy production, and slow down the aging process. Prioritizing glutathione optimization is key to promoting optimal health, longevity, and vitality for years to come.

PA wrote a 9-part series of articles on cholesterol on his website in 2012 entitled, "The Straight Dope on Cholesterol" that were the most informative I've ever seen but also puzzling. Perhaps we can have some discussion.
The puzzling parts to me are as follows:
Part 1, he states that 75% of cholesterol in the body is synthesized endogenously. Of that, 20% is synthesized by the liver and 80% by other cells. It isn't clear to me from this how much of the 80% enters circulation. He doesn't elaborate on the 80%, which is .75*.8=60% of the cholesterol in our body. Does the 60% enter circulation? Where is it made?
He then discusses cholesterol absorption mechanisms in the small intestine. The headline here was that there is esterified cholesterol (CE) and unesterified cholesterol (UC). Of these, the intestine can only absorb UC. He then says "Much (>50%) of the cholesterol we ingest from food is esterified (CE), hence we don’t actually absorb much, if any, exogenous cholesterol (i.e., cholesterol in food)". I immediately thought that 49% could be a meaningful amount. But based on that percentage he states that eating cholesterol has very little impact on the body. This is a position he reiterates throughout the series.
Interestingly, 85% of the UC (which is absorbable) in our gut is made by our own body. It is dumped into the intestine via biliary secretion. So the liver dumps cholesterol into the intestine, then the intestine re-absorbs it.
Here's where it gets interesting to me: his dietary recommendation to address heart disease at this point in time was a low carb diet. Now he seems to have moved away from that because many of his patients experienced sky-rocketing cholesterol (about 1/3 by his own report).
Fiber is not a dietary lever he mentions, yet I've seen studies indicating that it is effective at binding to cholesterol in the gut and thereby preventing re-absorption. So when the liver dumps cholesterol into the intestine it leaves the body instead of being re-absorbed. The production of short-chain fatty acids by fiber-fermenting bacteria also seem to help. Anecdotally there was a guy in cholesterol that reported cutting his cholesterol in half in part by consuming plenty of fiber.
Some links:
https://www.health.harvard.edu/blog/fiber-full-eating-for-better-health-and-lower-cholesterol-2019062416819
https://pubmed.ncbi.nlm.nih.gov/9925120/
https://www.medicalnewstoday.com/articles/how-fiber-helps-lower-cholestrol-and-what-to-eat#does-fiber-lower-cholesterol
Has PA missed this?

Hello, I'm making this post because I'm worried about some symptoms I've been experiencing. I know it's possible that it's all anxiety-related, but I'd like an extra opinion.
First of all, I'm male, 25 years old, 175cm tall, and weigh 66kg.
Over the past 12 months, I've been experiencing some symptoms like low blood pressure, dizziness, headaches, strong abdominal pains on the left side of the abdomen, diarrhea, and constipation. Dizziness is what bothers me the most, which comes along with a mental fog and a significant discomfort. I went to a doctor who recommended that I see a gastroenterologist. The gastroenterologist suggested that I undergo an endoscopy and a colonoscopy to investigate possible reflux and any intestinal issues, as some symptoms indicated this. I also had some allergy tests done, where I found out about lactose intolerance. Anyway, I managed to have the endoscopy done, and the results were good; we didn't detect anything. I haven't been able to have the colonoscopy done yet because the clinics in my city don't accept my health insurance. I went back to the gastroenterologist with the results, and he prescribed a probiotic and a prebiotic, which I've been taking until today. But since I still had some symptoms, I went back to the general practitioner, and he requested more routine tests, where we discovered elevated levels of urea, AST, and ALT.
Urea: 45mg/dL
Creatinine: 1.2 mg/dL
AST: 44 u/L
ALT: 75 u/L
Total Cholesterol: 161.0 mg/dL
HDL Cholesterol: 56.0 mg/dL
LDL Cholesterol: 90.4 mg/dL
VLDL Cholesterol: 14.6 mg/dL
Triglycerides: 73.0 mg/dL
Now, today, I'm experiencing some dizziness and a bitter taste in my mouth. I'm taking a hepatoprotector that my doctor recommended due to the above results; I'm not sure if this could be a side effect. As for yellowish skin, I haven't noticed anything, but I think the inner corner of my eye has some yellow lines, which has greatly increased my concern, to the point of coming here on Reddit to seek some opinions. Does anyone have any advice? Any specific doctor I should see? Any tests I should undergo? Anything I can improve in my diet/routine to treat my liver? I go to the gym 4 times a week; I do a workout that might be considered of moderate intensity. I'm very worried, so if anyone can help, I'd be grateful! If you have any more questions to better understand the situation, feel free to ask!

Hi. I’m 53 and have very recently found out I have multiple large cysts (up to 7.6 cm) on both lobes of of my liver and both kidneys and a 7 mm kidney stone.
(I’ve since got the stone to the point where it’s only got a couple inches more to go before exiting, using lots of water and Chanca Piedra supplements).
So it’s a lot to take in, as you all know ❤️‍🩹 I’m fit and active, don’t drink or eat meat etc, no history of PKD or PLD in my family that I know of. My adult daughters have had ultrasounds and are both clear. (19 and 34 yrs).
All my bloods tests come back “perfect” - no impaired kidney function etc.
So having had it slammed home to me repeatedly by my GP and the liver and kidney specialists at my medical clinic that “there is nothing that can help, the cysts NEVER shrink or go away” etc etc, I’m questioning the wisdom of going ahead with separate CT scans - one for my liver at one hospital, and one on my kidneys and also my brain because my grandmother had a brain aneurysm.
CT scans are known to have a cumulative effect of increased cancer risk right!??
So I’m asking myself: if there’s nothing that can be done and other than moderate, occasional pain management at this point from pressure on my inner ribs and kidney stone, why would I do something (CT scans) that could potentially increase my risk of cancer? I’m very interested in your collective opinions and experiences.

You’ve all likely taken a pain medication at some point, so I thought I might offer a little more info about some of the different types.
Acetaminophen (Tylenol) is great for pain and fever, but it is not an anti-inflammatory medicine. Acetaminophen is known to cause liver damage when taken in large quantities, and this medication is included in many different OTC formulations such as cough and cold medicines. Patients should always check ingredients to ensure they are not double dosing unintentionally, and limit use when possible.
The term Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) encompasses a wide range of medications that help with pain, fever, gout, blood clots, and inflammation. Because these medications work differently from acetaminophen, it is generally safe to use both if your primary issue is pain and/or fever; however, you should never use two types of NSAIDs together due to their adverse drug effect (ADE) risks.
All NSAIDs are known to cause kidney damage, but liver damage is possible in high doses. In addition, some NSAIDs can increase the risk of bleeding, cause heartburn and stomach ulcers, increase blood pressure, cause heart problems or stroke, and may cause allergic reactions. Frequent/long term use is not recommended without oversight by a physician. NSAIDs are best taken with food and possibly a H2RA/PPI (see previous reflux post for more info on these meds) to help prevent GI bleeding.
Some common NSAIDs include: Aspirin (Bufferin, Ecotrin-low dose used often for blood clot prevention) Ibuprofen (Advil, Motrin) Naproxen (Aleve, Naprosyn-12h dosing) Diclofenac (Voltaren-topical options available; higher risk for liver and heart ADEs) Indomethacin (Indocin) Meloxicam (Mobic-24h dosing) Ketorolac (Toradol-high risk for ADEs; use should be limited to 40mg max daily and 5 days use) Celecoxib (Celebrex-less risk of GI ulcers but increases risk of heart problems)
Also note that children with viral infections should NOT take aspirin due to the risk of Reye’s Syndrome
Corticosteroids (different from anabolic steroids) are synthetic versions of cortisol that are also used for inflammation by affecting the body’s immune response. They are commonly used for allergies, asthma, arthritis, and autoimmune diseases, yet they can have a wider variety of ADEs especially when used systemically, such as weight gain/water retention, mood changes, increased body hair growth, increased risk of infection/difficulty fighting infections, easy bruising, GI bleed risk, increased blood pressure and sugar, etc. Some examples are cortisone, hydrocortisone, methylprednisolone, prednisolone, prednisone, triamcinolone, betamethasone, dexamethasone, and fludricortisone. (NSAIDs and steroids should not be taken together.)
Lidocaine and/or menthol is also a great option for pain that is available in many different dosage forms. Some antidepressants like selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), or tricyclic antidepressants (TCAs) and some anticonvulsants can be used for certain chronic pain conditions. Muscle relaxers are useful for muscle tension and spasms.
When necessary opioid pain medications may be prescribed. These should only be used as directed because they carry high risks for ADEs, such as respiratory depression and dependence. Opioids cause intestinal movement to slow resulting in constipation so it’s important to also take senna, which directly stimulates the intestines to move, otherwise you get “all mush, no push” if you only use other constipation meds! 🤪
P.S. Physical therapy and dry needling can also be a great way to relieve pain!! I get needling regularly for my myofascial pain syndrome so I can attest that it helps tremendously!🤩
This website has some great additional info if you want to check it out!