I have always been interested in what my DNA has to say about me. I already did the big tests, Ancestry and 23andMe, but I wanted to give mynucleus.com a try since they make some pretty big claims. What do we think of the results? I'm curious about next steps now that I have this information.
Alcohol Dependence Risk
The first report that caught my attention was for my alcohol dependence risk. I had no idea that this could be genetic! Apparently I am at a much higher risk for alcoholism than the typical person. My risk is about twice as high as the gen pop.
This actually makes sense. Several members of my family have struggled with alcoholism over the years. Looks like genetics may be part of the picture.
I have been toying with giving up alcohol but this report gave me the push I needed. I’ve decided to take a pretty significant lifestyle change and to mostly give up alcohol. I’ll still drink it on special occasions like a wedding toast, but that’ll be it.
https://preview.redd.it/v6q4ks9fqt1d1.png?width=1336&format=png&auto=webp&s=8f34d2145e89029b9a2203740713356da0702c32
https://preview.redd.it/h3ia0gkkrt1d1.png?width=1168&format=png&auto=webp&s=3485e28d352fab4fb82d5869436f00dcc8f67b1f
Insomnia
I’ve always had trouble falling and staying asleep and I was curious to see if it was genetic. Super interesting to see that my age and being male are related to my risk.
Before this result I had been trying to establish a routine where I minimize blue light with special light bulbs and stop using my iPhone a few hours before going to sleep. I am going to double down on my efforts and buy an 8sleep mattress to help help me sleep better and track my sleep to see if these changes are paying off. I've also looked into other options, such as restricting the time of my last meal and exercise. Do folks have any other suggestions here?
Alzheimer’s
Although my report showed I am at low risk for Alzheimer’s with a score of -1.36, I am still worried because Alzheimer’s runs in my family. They do more extensive testing in their Premium package, so I’m going to try that to get a higher quality analysis for Alzheimer’s, hopefully to just put my mind at ease about it. I took a deeper look at my results and saw these lines in the key takeaways section:
https://preview.redd.it/rmx8tr2vqt1d1.png?width=1245&format=png&auto=webp&s=46858a24f2aac31a8f58870f96e2c3a724c3b544
Looks like there are some causes for Alzheimer’s that aren’t tested with the upload product, Basic. I have ordered their whole-genome sequencing product, Premium, to see if I have any of these 400+ variants.
After doing a little reading on their site, it looks like this is an issue with the uploaded DNA data–the microarray technology companies like 23andMe and Ancestry use look at only around 0.1% of my DNA. Premium uses whole-genome sequencing to look at almost 100% so it can find variants that those other tests miss.
Other diseases
I looked through some of the other reports like multiple sclerosis, male breast cancer, prostate cancer, and others but they all pretty much had lower or typical risk. Until I got to type 2 diabetes. I don’t know of anyone in my family at risk but I have a really high score of 2.2. After some google searches, I am definitely going to ask my doctor for regular screenings of my A1C and fasting glucose numbers.
Conclusion
Overall, my experience with Nucleus was seamless and I’m very happy with the product. The reports were clear and looked great. They were much better than my 23andme reports.
The whole process took about a week and I just ordered the Premium whole genome kit. After submitting my Ancestry DNA file, I got my Nucleus results in about a week. I did feel like the sign up process was a little exhausting, with them asking very specific questions such as my blood pressure and A1C result. It seems like they combine these to calculate some risk scores, but I didn't have this information handy during sign up and I couldn't skip these questions and return to them later.
All in all their portal is quite intuitive, and I really love the design. It definitely feels like a major step up from the outdated, 2010s design of competitors like 23andme.
Once inside, I looked to see what I could find out. I clicked on the “View results” button and saw a list of 20 diseases. This didn’t feel like a lot of diseases so I reached out to customer support to ask about it. They informed me that through my subscription, I would be receiving new reports for both diseases and traits periodically. Pretty good for just $39/year!
I did like that Basic analyzed some diseases that 23andMe didn’t and that their Premium sequencing is done in the US. I had previously considered doing Nebula, but was worried because they would have sent my sample to China. I didn’t want this to happen for obvious reasons.
I also really appreciated their privacy measures. They seem quite transparent about their data-sharing policies, and they default opt-you out of sharing your data for research.

Magnesium is important for:
Energy production. Blood pressure regulation. Normal heart rhythm. DNA and RNA creation. Bone structure development. Nervous system regulation. Insulin regulation ⬇️ https://mcpress.mayoclinic.org/nutrition-fitness/magnesium-glycinate-is-this-supplement-helpful-for-you/
Signs of Magnesium Deficiency

1. Twitching Muscles (eyelids)
2. Waking up between 2-3am. (high cortisol)
3. Irritation (nervousness, low blood sugar)
4. Heart Flutters (arrhythmias)
5. High Blood Pressure (Hypertension)
6. Constipation (irregular bowel movements)
7. Bone Pain (Osteopenia) 60% Magnesium in body is stored in the bones
8. Stiff Joints (Arthritis)
9. Anxiety (Stress) Magnesium + B1
10. Chocolate Cravings (stress= adrenaline & cortisol response)
11. Clawed Hands or Feet (Carpopedal Spasms=commonly in feet at bedtime)
12. Muscle Cramps (spasms=calf muscle, back, neck/electrolyte imbalance)
13. Asthma (Magnesium + Vit D3, K2 to improve asthma symptoms)

Only "1%" of Magnesium is stored in the blood, thereby making tests for Magnesium Deficiency null & void as 60% of the body's magnesium is stored INSIDE the bones. This is why Magnesium Deficiency is overlooked & ignored by doctors, resulting in billions of people living with Magnesium Deficiency.
75% of humanity has an "Invisible Deficiency" of Magnesium.
400-800mg daily supplementation is recommended for optimal health/reduction in Deficiency symptoms.
Causes of Magnesium Deficiency: 1. Grains 2. Fructose 3. Soda 4. Soil depletion 5. Emotional stress 6. Antacids , Diuretics, Pharmaceuticals 7. Deficiency in VitD=Sunshine exposure
To fix Deficiencies: Magnesium Glycinate supplements, 400-800mg daily, eat dark leafy green vegetables daily, use celtic sea salt (also add a pinch in daily Filtered drinking water) .. ⬇️ https://youtu.be/emkLyutJ71Q?si=fcMhRijbZKug2Tge
Magnesium is vital to support the energy required for the body, cells, organs, and DNA to prevent degenerative diseases that are responsible for chronic diseases and premature death. ⬇️ https://youtu.be/J6aVE1Lo6Dw?si=Qz2DAegFQ1jEgcJq
Magnesium Glycinate is an orally available magnesium salt of glycine. Magnesium activates over 600 enzymes and is essential for DNA and RNA synthesis, cellular repair, and maintaining the antioxidant status of the cell. Magnesium plays a key role in bone and muscle function and assists in the activation of vitamin D, which helps regulate calcium and phosphate homeostasis to influence the growth and maintenance of bones. ⬇️ https://pubchem.ncbi.nlm.nih.gov/compound/Magnesium-glycinate
Randomized Controlled Trial:
The effect of combined magnesium and vitamin D supplementation on vitamin D status, systemic inflammation, and blood pressure: A randomized double-blinded controlled trial
Poor vitamin D and magnesium status is observed in individuals who are overweight and obese (Owt/Ob) and is often associated with a heightened risk of cardiovascular disease. Magnesium is a cofactor that assists vitamin D metabolism. ⬇️ https://pubmed.ncbi.nlm.nih.gov/35576873/
Safest, fewest ingredients available for Magnesium Glycinate ⬇️ https://www.amazon.com/gp/aw/d/B0C8DMMYTC/ref=ox_sc_act_image_1?smid=A37SM01TLWSF12&psc=1
Safest, fewest ingredients available for Vitamin D3 (1 year supply) ⬇️ https://www.amazon.com/gp/aw/d/B00JGCBGZQ/ref=ox_sc_act_image_1?smid=AQAIDN8YDF665&psc=1&th=1
Magnesium, D3, and potassium work synergistically, in tandem, for better absorption and better utilization in the body for optimal health benefits.

Many of you saw my previous post about being denied treatment because my TSH was at 0.03 and for my hospital in my area to treat, I need to be at 0.01. (Please go see my other post to understand why this is so upsetting)
I went to my PCP because my symptoms were getting worse, my eyesight is worse, migraines etc. He looked at my chart after I told him everything that’s going on, and saw that I was down 5 more pounds since the last time I saw him. He told me that’s not normal, my endo should have retested because the labs were not accurate by the time my endo appointment came around, and that he is going to push the test through now anyway.
My TSH is at 0.01!!!
My T3 and T4 are on the high end of normal, about 2 units away from being in hypo.
I’ve never been so excited about my disease progressing. He said it was likely this low at the time of the appointment, and if we would have waited the 6 months as she has advised, I would have gotten significantly worse and with all of my symptoms, I may have ended up hospitalized due to the severity of my migraines. He prescribed me a beta blocker and some vitamins to take (magnesium and b12) but I have yet to see any difference. I’m assuming there’s only so much these things can do.
I am angry. My Mother’s Day was ruined because my graves was not treated correctly, I spent the entire day in the dark of my room with most of my vision gone. My life is affected greatly by this for the past 2 months, and I would have to wait four more if I had listened to my endo. I feel like she made a huge mistake, and part of me wants to retaliate and report her, another part of me knows that I don’t have the energy or bandwidth to withstand that stress. I am grateful that my PCP is advocating for me, he offered to talk to my endo directly but I have not made a decision yet on what I’d like to do. It has only been a few days since I got my results back.
I am on the schedule to go to the college hospital near me that is highly highly recommended, but that is also not until August, and that is very soon as far as this hospital goes. Some people wait years. I do not want to return to the catholic hospital I was going to, but I believe it may be my only option. My mother is a nurse and has been keeping up with me. I want to get help, but I refuse to see the same doctor. My mom said “they will most likely talk shit about you, and will be less likely to help you because the endo you saw will convince them that treatment is not necessary if that’s what she believes. You should just trust her and wait.” Which is a whole different stressor in itself. I don’t know what part of the nurse training brainwashes them to never question any doctor, but it’s disheartening.
I guess I’m just looking for support, and advice as to whether I should go back to my endo, or see a different doctor in the same office, but otherwise I’m out of luck until August. I want to feel better!!

I've been searching for gratitude and counting the blessings I'm the middle of the chaos. However I could really use some verses or points of encouragement.
To preface, I have an autoimmune disease and nothing will trigger a bad flare faster than stress. My grandmother has been ill and now we've put her in the hospice program but she's still at home. To manage care however it requires three of us within a 24 hour time to take shifts, sometimes overlapping, feeding, lifting her for the bathroom, meds, breathing treatments, etc. Occasionally we have other family able to sit with her but they can't to the more difficult tasks and my grandmother is a very modest and private person. Bringing in someone to help isn't an option as it will cause her additional stress. My parents are still with me and I feel very blessed with that, however my mother a few years ago had a brain hemorrhage and it effected her in a way similar to Alzheimer's and she is sometimes emotionally childlike and can have outbursts and so far I've feel like I have been able to somewhat manage helping her handle those but with the family stress of my grandmother's illness and her no longer having her routine, it has become harder for her and in turn me being able to help her. Then yesterday I found out my Dad has cancer. Stage 1 and operable but it's cancer.
These are the big ones. Work, marriage and other family issues we all have of course factor in but right now I'm just trying to manage on the most basic level.
I can find some obvious blessings in all of this. My dad's cancer was found early. Right now I'm physically in a state of remission. My mom's illness, even though more challenging, will be more manageable when things settle down. My grandmother has not had any pain. My job, although it's a huge financial stress right now and bills are piling up, is at least flexible in giving me this time to help her. My husband is trying hard to be supportive and my kids are healthy. So I give glory to God in all things because what seems pretty awful can bring blessings. However, I am tired. I am so unbelievably tired and I could use some points of perspective. I don't think I've even opened my Bible in weeks although I know that's where I should start.
You have always been great about leading others through a crisis. So this time I am the one looking for some help to lead me though.
Thanks in advance. ❤️

DAY: MAY 20 2024
5-20-2024

Why nightmares and ‘daymares’ could be early warning signs of autoimmune disease

An increase in nightmares and hallucinations—or ‘daymares’—could herald the onset of autoimmune diseases such as lupus, say an international team led by researchers at the University of Cambridge and King’s College London. The researchers argue that there must be greater recognition that these types of mental health and neurological symptoms can act as an early warning sign that an individual is approaching a “flare,” where their disease worsens for a period.
5-20-2024 Yoga and meditation-induced altered states of consciousness are common in the general population, study says
Yoga, mindfulness, meditation, breathwork, and other practices are gaining in popularity due to their potential to improve health and well-being. The effects of these practices are mostly positive and occasionally transformational, yet they are known to sometimes be associated with challenging altered states of consciousness. New research by a team including investigators from Massachusetts General Hospital reveals that altered states of consciousness associated with meditation practice are far more common than expected. Although many people reported positive outcomes, that were sometimes even considered transformational, from these experiences, for a substantial
5-20-2024 Examining the benefits of out-of-network care for pediatric moyamoya
Total in-episode expenses and resource use before the index surgery (preop) and including/after the surgery (postop). The comparisons are separated for analysis into (A) single institution cohorts (1 and 2) and (B) multi?institution cohorts (3 and 4). Moyamoya disease is a rare condition that affects the blood vessels in the brain, especially in children. Narrowing and blockage of vessels significantly increases the risk of stroke and requires surgical revascularization for treatment. Although research shows that outcomes of revascularization are better
5-20-2024 Study explores links between social media use, mental health and sleep quality
The more time you spend on social media, the greater the likelihood of having unpleasant social-media related dreams that cause distress, sleep disruption and impact our peace of mind. Flinders University’s Reza Shabahang says that the vast and rapid adoption of social media has the potential to influence various aspects of life, including the realm of dreaming. “As social media becomes increasingly intertwined with our lives, its impact extends beyond waking hours, and may influence our dreams,”
5-20-2024 How are asthma and heart health linked?
Although the heart and lungs are neighbors in your chest, people may think of them as separate entities with unrelated problems. But a growing body of evidence suggests that asthma—one of the most common lung disorders—is a risk factor for cardiovascular disease. Asthma is a serious chronic disease in which airways are inflamed, often in response to specific triggers. It affects about 25 million people in the U.S., including nearly 5 million children, causing millions of annual visits to doctors’ offices and emergency rooms. “We call these major changes
5-20-2024 STUDY EXPLORES PATIENT TRUST IN PHYSICIANS
Trust in one’s physician drives positive health practices. In a scoping review, SUNY Poly Professor of Sociology Dr. Linda R. Weber discovered new developments in the measurement of trust, identified those measures of trust that have known reliability and validity, and compared those instruments’ conceptualizations, dimensions, and indicators. The paper is published in the journal PLOS ONE. Weber explains that 10 dimensions emerged from the study: fidelity, technical competence, communicative competence, interpersonal competence (i.e., caring), honesty, confidentiality, global, behavioral, fairness, and system trust/accountability. In addition, these findings provide the foundation
5-20-2024 TIMESAVING TIPS FOR COOKING HEALTHY MEALS
Living a busy, fast-paced life can make it hard to find the motivation to cook a healthy meal at home. However, learning some shortcuts in the kitchen can keep your healthy eating goals on track and help you avoid grazing on unhealthy snacks, grabbing the first thing you see in the fridge or going out for fast food. Why cook at home? Research shows that maintaining a healthy weight is challenging when you eat out too frequently. Restaurant portions often are super-sized
5-20-2024 UNDERSTANDING PERIMENOPAUSE VS. MENOPAUSE
Menopause marks a significant transition for women, yet understanding its precursor, perimenopause, and its symptoms can be complex. Dr. Stephanie Faubion, director of Mayo Clinic’s Center for Women’s Health and medical director of The Menopause Society, says experiencing perimenopause and menopause can be confusing for some. She says it is not only patients who may find it confusing, but medical providers as well, due to lack of training in menopause management. “Menopause is defined by no menstrual cycle for a year,” says Dr. Faubion.
5-20-2024 LOW-DOSE IRON SUPPLEMENTATION HAS NO BENEFIT FOR BREASTFED INFANTS, SHOWS STUDY
The American Pediatric Association recommends iron supplements to all healthy infants who breastfeed longer than four months, while its European counterpart, Society of Gastroenterology, Hepataology and Nutrition, does not recommend it. These deviating guidelines stimulated researchers to design a new study. Breastfeeding is strongly recommended, and the proportion of children are breastfed during the first half of life is high. The researchers wanted to determine whether breastfeeding babies could benefit from extra iron.
5-20-2024 ALLERGY MEDICATIONS COME WITH HAZARDS: BE AWARE
People with seasonal allergies often turn to over-the-counter and prescription medicines to relieve symptoms like coughing, sneezing, runny nose, congestion and itchy eyes, nose or throat. But they often aren’t aware that these meds—including antihistamines—have as much risk for potential side effects, drug interactions and overdose as other drugs. “All medicines have side effects associated with them even when they are taken appropriately and according to dosing directions on the label,”
5-20-2024 I CAN’T AFFORD OLIVE OIL—WHAT ELSE CAN I USE?
If you buy your olive oil in bulk, you’ve likely been in for a shock in recent weeks. Major supermarkets have been selling olive oil for up to A$65 for a four-liter tin, and up to $26 for a 750 milliliter bottle. We’ve been hearing about the health benefits of olive oil for years. And many of us are adding it to salads, or baking and frying with it. But during a cost-of-living crisis, these high prices can put olive oil out of reach. Let’s take a look at why
5-20-2024 Researchers uncover biological trigger of early puberty
Heather Brenhouse, associate professor of psychology, says disrupting the caretaker relationship can really traumatize a child or a developing rodent. Credit: Ruby Wallau/Northeastern University New research conducted by the Brenhouse Lab reveals how early life adversity triggers early puberty and late-life anxiety, paving the way for potential interventions. The onset of puberty has been creeping downward for decades. In the United States, the average age of girls reaching puberty ranges from 8.8 to 10.3 years old. The early start of puberty, which is associated with many health risks, can be
5-20-2024 Bioluminescence and 3D-printed implants shed light on brain–spinal interactions
Brain-spinal cord duet’s neurodynamic symphony is now accessible to scientists via novel multi-organ implants. Credit: Dmitrijs Celinskis A sensory process such as pain is no ordinary phenomenon—it’s a symphony of neural and vascular interactions orchestrated by the brain and spinal cord. Attempting to dissect this symphony by focusing on a single region is like trying to understand a complex melody by listening to just one instrument. It’s incomplete, potentially misleading, and may result in erroneous conclusions. Enter the Carney Institute’s team of visionaries. Their mission? To develop tools that allow
5-20-2024 New thesis explores cancer treatment that can prevent relapse
. What is the main focus of your thesis? Relapse following initial treatment efficacy remains a major clinical challenge for many cancers. The focus of my thesis has been to explore the therapeutic impact of immune cells in patients with blood cancer (leukemia), by first investigating which cells
5-20-2024 New study reveals health and social benefits of car-free living
Participating in a three-week car-free challenge has enhanced the health and well-being of Oxford residents, according to research conducted by The University of Bath’s Centre for Climate Change and Social Transformations (CAST), in partnership with climate charity Possible and Low Carbon Oxford North (LCON), conducted this research project. After ditching their cars for three weeks, 10 out of the 12 drivers across Oxford who participated said they plan to continue with reduced car use beyond the project. The findings of this research project show that: Day-to-day transport emissions were slashed
5-20-2024 Research shows linked biological pathways driving skin inflammation
A certain biological pathway—a set of linked reactions in the body—drives the inflammation seen in the skin disease psoriasis, a new study finds. The work could lead to improved therapies for all inflammatory skin diseases, including atopic and allergic dermatitis and a type of boil called hidradenitis suppurativa, say the study authors. The findings are published in the journal Immunity. Inflammation is the body’s natural response to irritation and infection, but when out of control, it can lead to the reddish, flaky, itchy lesions that
5-20-2024 Prescription co-payments linked to more hospital admissions in New Zealand, study finds
A new study from researchers cautions that bringing back the $5 co-payment for prescription medicines could see a jump in hospital admissions. The study analyzed health data for 71,502 people and found those who didn’t pick up a prescription because they couldn’t afford the $5 fee had a 34% higher rate of being admitted to hospital.
5-20-2024 How a simulation is informing COVID-19 vaccine policy after our ‘return to normal’
As the saying goes “There is no such thing as normal” and this has been especially true after the pandemic. Before the emergence of the omicron COVID-19 variant, countries like the U.K. had high vaccination coverage along with widespread exposure to COVID-19 in the population. This combination of vaccine and infection-derived immunity is termed hybrid immunity and is different to vaccine immunity or infection immunity alone. In contrast, other countries, including Australia, New Zealand and those in the Western Pacific, had a very different pandemic experience.
5-20-2024 Researchers find intriguing connections between Alzheimer’s disease and other common conditions
A study has found that while some medical conditions appear to increase our likelihood of developing Alzheimer’s disease, others appear to decrease the odds. The study, led by Dr. Yijun (Nicholas) Pan and Dr. Liang Jin, analyzed data from 2,443 older Australians living in Melbourne or Perth who are part of the Australian Imaging, Biomarker and Lifestyle (AIBL) study, an internationally recognized cohort for dementia research. “We found anxiety and other neurological disorders are associated with increased likelihood of Alzheimer’s disease,” Dr. Pan said.
5-20-2024 Prepping autistic or sound-sensitive kids for cicada noise
As Chicagoans await the emergence of the cicadas, parents of children on the autism spectrum and/or who have sensitivities to sound can take a few steps to prepare for what is expected to be a loud summer. “Some children on the spectrum can struggle with loud or unexpected noises, such as toilets that automatically flush, fireworks around the Fourth of July or the emergence of a large number of cicadas,”
5-20-2024 Study highlights importance of screening for rare inherited iron metabolism defects
Over 40% of cases curated based on stringent clinical and laboratory criteria from the Indian subcontinent have an inherited iron metabolism defect on comprehensive genomic evaluation, report investigators in The Journal of Molecular Diagnostics. Although iron deficiency anemia is the most prevalent form of anemia globally,
5-20-2024 Study finds tyrosine kinase Csk promotes germinal center B cell survival and affinity maturation
The authors found that Csk (a tyrosine kinase that attenuates B cell receptor signaling) is required for germinal center maintenance and efficient antibody maturation. The immune system strikes a fine balance by identifying and neutralizing disease-causing agents while carefully avoiding destruction of healthy tissues and cells. Now, researchers from Japan have shed new light on one of the processes that helps train immune cells to act only against genuine threats.
5-20-2024 Significant gaps between science of obesity and the care patients receive, say experts
As research continues to produce evidence about the underlying causes of obesity and optimal strategies to treat and manage obesity have evolved, there are disparities in application of the latest scientific advances in the clinical care that people with obesity receive. Widespread adoption of current findings, consistency of care and expertise in obesity care varies by health care professional and institution.
5-20-2024 Improving online depression treatment
Symptom course of depression for individuals who dropped out of treatment and those who completed treatment. In the dropout group, there is an initial decrease in symptoms while the patients were still in treatment, which tapers off as they drop out. For completers, there is close to a linear change over time. This suggests there is a relation between the more that an individual continues to participate in ICBT and their depressive symptom improvement.
5-20-2024 Women face worse chronic kidney disease management in primary care
Women receive worse primary care-based chronic kidney disease (CKD) management than men, according to a research letter adult patients with CKD receiving primary care at 15 practices using electronic health record data to examine sex disparities in guideline-based CKD management
5-20-2024 Bisoprolol does not reduce exacerbations in at-risk COPD patients
For patients with chronic obstructive pulmonary disease (COPD), bisoprolol does not reduce the number of self-reported exacerbations treated with oral corticosteroids, antibiotics, or both, according to a study
5-20-2024 Anticancer potential of CLK kinase inhibitors 1C8 and GPS167 via EMT and antiviral immune response
The diheteroarylamide-based compound 1C8 and the aminothiazole carboxamide-related compound GPS167 inhibit the CLK kinases, and affect the proliferation of a broad range of cancer cell lines. A chemogenomic screen previously performed with GPS167 revealed that the depletion of components associated with mitotic spindle assembly altered
5-20-2024 Study sheds light on bacteria associated with pre-term birth
Researchers from North Carolina State University have found that multiple species of Gardnerella, bacteria sometimes associated with bacterial vaginosis (BV) and pre-term birth, can coexist in the same vaginal microbiome. The findings, published in mSystems, add to the emerging picture of Gardnerella’s effects on human health. Gardnerella is a group of anaerobic bacteria that are commonly found in the vaginal microbiome. Higher levels of the bacteria are a signature of BV and associated with higher risk of pre-term birth, but it is also found in women who have no sign
5-20-2024 New AI model uses federated learning for multi-organ segmentation based on medical image data
Researchers have successfully developed the technology that can accurately segment different body organs by effectively learning medical image data used for different purposes in different hospitals, which is expected to greatly contribute to the development of large-scale medical AI models in the future.
5-20-2024 Second Phase 3 clinical trial again shows dupilumab lessens disease in COPD patients with type 2 inflammation
Chronic obstructive pulmonary disease patients with type 2 inflammation may soon gain access to a new drug—dupilumab—that showed rapid and sustained improvements in patients in a pivotal Phase 3 clinical trial, researchers report in the New England Journal of Medicine. This monoclonal antibody is the first biologic shown to improve clinical outcomes in COPD. The data supporting the use of dupilumab in COPD will be reviewed by the United States Food and Drug Administration in June. The disease improvements—as measured by a significantly lower annualized rate of acute exacerbations
5-20-2024 New AI model uses federated learning for multi-organ segmentation based on medical image data
Researchers have successfully developed the technology that can accurately segment different body organs by effectively learning medical image data used for different purposes in different hospitals, which is expected to greatly contribute to the development of large-scale medical AI models in the future.
5-20-2024 Second Phase 3 clinical trial again shows dupilumab lessens disease in COPD patients with type 2 inflammation
Chronic obstructive pulmonary disease patients with type 2 inflammation may soon gain access to a new drug—dupilumab—that showed rapid and sustained improvements in patients in a pivotal Phase 3 clinical trial, researchers report in the New England Journal of Medicine. This monoclonal antibody is the first biologic shown to improve clinical outcomes in COPD. The data supporting the use of dupilumab in COPD will be reviewed by the United States Food and Drug Administration in June. The disease improvements—as measured by a significantly lower annualized rate of acute exacerbations

• 5-20-2024GALLBLADDER CANCER RISES AMONG BLACK AMERICANS AS CASES DECLINE IN OTHER GROUPS
• 5-20-2024US PEDIATRICIANS REVERSE DECADES-OLD ADVICE AGAINST HIV-POSITIVE MOTHERS BREASTFEEDING
• 5-20-2024UK REPORT FINDS COVER-UP OF DECADES-LONG INFECTED BLOOD SCANDAL
• 5-20-2024ASTRAZENECA TO BUILD $1.5 BLN CANCER DRUG FACILITY IN SINGAPORE
• 5-20-2024CHEMO FOR GLIOBLASTOMA ENHANCED BY TAPPING INTO CELL’S DAILY RHYTHMS
• 5-20-2024RESEARCH SHOWS THAT FERROPTOSIS, A FORM OF CELL DEATH, OCCURS IN SEVERE COVID-19 PATIENT LUNGS
• 5-20-2024BODY’S ‘MESSAGE IN A BOTTLE’ DELIVERS TARGETED CANCER TREATMENT
• 5-20-2024EARLY BLOOD GLUCOSE CONTROL FOR THOSE WITH TYPE 2 DIABETES CRUCIAL FOR REDUCING COMPLICATIONS, PROLONGING LIFE
• 5-20-2024GRID CELL RESPONSES TO THE ILLUSION OF SELF-LOCATION
• 5-20-2024RESEARCHERS DISCOVER TOP-DOWN SIGNALS IN BRAIN CIRCUITS REGULATING DEPRESSION
• 5-20-2024BENIGN NAIL CONDITION LINKED TO RARE SYNDROME THAT GREATLY INCREASES CANCER RISK
• 5-20-2024RESEARCHERS REVEAL PROMISING TREATMENT TARGET FOR RESISTANT BRAIN CANCER
• 5-20-2024NEW MECHANISMS UNDERLYING TUMOR VARIETY IN BRAIN CANCERS DISCOVERED
• 5-20-2024STUDY EXPLORES PATIENT TRUST IN PHYSICIANS
• 5-20-2024MOTIVATED BY LACK OF DIVERSITY IN NEUROLOGICAL STUDIES, SCIENTISTS LOOK TO ENSURE EQUITY IN BRAIN RESEARCH
• 5-20-2024FLUORIDE EXPOSURE DURING PREGNANCY LINKED TO INCREASED RISK OF CHILDHOOD NEUROBEHAVIORAL PROBLEMS, STUDY FINDS
• 5-20-2024STUDY SUGGESTS BOTH STEP AND TIME-BASED EXERCISE TARGETS ARE EQUALLY BENEFICIAL
• 5-20-2024MEDICAID ‘UNWINDING’ DECRIED AS BIASED AGAINST DISABLED PEOPLE
• 5-20-2024TIMESAVING TIPS FOR COOKING HEALTHY MEALS
• 5-20-2024UNDERSTANDING PERIMENOPAUSE VS. MENOPAUSE
• 5-20-2024LOW-DOSE IRON SUPPLEMENTATION HAS NO BENEFIT FOR BREASTFED INFANTS, SHOWS STUDY
• 5-20-2024IS IT BIRD FLU JUST AN ANIMAL THING, OR CAN PEOPLE CATCH IT?
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Just received this diagnosis a couple of days ago and I feel like my life is shattering. I have to mention I don't suffers from any important symptoms, apart from the occasional bloating and flatulence, I've simply came across this disease while studying in medschool, knowing I have Hashimoto's already so I went down this path of checking if I have AAG or not. And long story short the biopsy's result came back and I have stage 3 (out of 3) atrophy and stage 1 metaplasia (also out of 3) in the corpus, with the fundus and antrum seemingly healthy. On top of that, as if it weren't enough already, I also have H. pylori.
I talked to as many doctors as I could in such a limited timeframe and all of them suggested I take vitamin B12 shots for all my life (which wouldn't be a problem), and have regular screenings of my stomach to keep track of the atrophic and metaplasic progression.
What I'm most scared of, if you didn't guess already, is cancer. Stomach adenocarcinoma is one of the most violent and quickly-spreading types of cancer. Also being so young, 21, makes me think this disease has around 50 or so years to develop alongside me, which would give it more than enough time to take me out.
Has anyone here battled with AAG from such a young age as me? Any help? Any tips?

Pesto is a nutritious sauce and condiment available in many tasty variations, but is pesto keto-friendly?
Yes, traditionally prepared pesto is low in carbs and can be a great way to add depth of flavor to various keto recipes.
Discover the benefits of regularly incorporating pesto into a ketogenic diet and learn how to make the best Healthy Keto® pesto recipe.

What is pesto?

Originating from Genoa, Italy, authentic pesto sauce is crafted from simple ingredients, including fresh basil leaves, garlic, parmesan cheese, pecorino cheese, pine nuts, olive oil, sea salt, and pepper.
The name pesto comes from the Genovese word pestare, which means to pound or crush. It depicts the traditional method of preparing pesto using a mortar and pestle to combine ingredients.
Here are common ingredients used in different pesto varieties.

Common herbs used in pesto

The original pesto recipe, Pesto alla Genovese, exclusively uses Genovese basil as the primary herb due to its unique sweetness.
Basil is a delicate herb, and using the mortar and pestle instead of harshly chopping or blending with a food processor slows down the oxidation of the leaves. This not only helps preserve the sauce's vivid green hue but also enhances its flavor and aroma.
However, pesto has evolved to encompass a broader range of ingredients.
Here are some other common herbs used in many pesto recipes:

• Italian flat-leaf parsley
• Cilantro
• Mint
• Oregano

In addition to herbs, many pesto sauces incorporate ingredients such as arugula, spinach, kale, lemon juice, or tomatoes.

Common nuts used in pesto

Similarly, some recipes replace the traditional toasted pine nuts with other types of nuts to add a unique twist to the classic dish.
Here are some commonly used nuts used to prepare pesto:

• Almonds
• Cashews
• Walnuts
• Pecans
• Pistachios

Is pesto keto-friendly?

Traditional pesto is low in carbohydrates and contains less than one gram of net carbs per tablespoon. This makes pesto an excellent keto-friendly option that offers impressive flavors.
However, since there are many different pesto variations, it’s crucial to read labels to check that there are no added sugars or hidden carbs that could interfere with ketosis.
For those following Healthy Keto, a low-carb diet that focuses on nutrient-dense whole foods, checking the ingredients list is essential, as many pre-made pestos can include potentially harmful additives and preservatives.
Watch this video to discover the health and nutritional benefits of basil.
Amazing Health & Nutritional Benefits Of Basil

4 health benefits of pesto

Authentic basil pesto combines several superfoods high in nutrients, offering many potential health benefits.
Here are four reasons why you should incorporate more pesto into your meals.

1. Anti-aging properties

Research published in Frontiers in Nutrition shows that healthy fats, particularly the monounsaturated and polyunsaturated fatty acids found in olive oil, can improve brain function and help reduce the risk of cognitive decline.
These fatty acids are also vital for supporting eye health and contribute to healthier skin by improving skin barrier function and hydration.

2. Supports the immune system

According to a study published in Foods, Genovese basil is particularly rich in polyphenols, including rosmarinic and caffeic acid.
These health-promoting compounds have been linked to potent anti-inflammatory effects that support immune system function and may lower the risk of chronic diseases.
3. Potential anti-cancer effects
Key ingredients in pesto, including basil, garlic, and olive oil, are exceptional sources of antioxidants that may help lower cancer risk.
Antioxidants can counteract the effects of free radicals, thereby preventing oxidative stress, which is linked to cellular and DNA damage, a leading cause of cancer.

4. Promotes digestive health

Parmigiano Reggiano, widely considered the best cheese for pesto, contains digestive enzymes and beneficial gut bacteria, also known as probiotics.
Probiotics help maintain a healthy gut microbiome essential for nutrient absorption, digestive health, and overall well-being.
Research published in Food Technology and Biotechnology found that Parmigiano Reggiano also contains oligosaccharides, which act as a prebiotic food source for beneficial gut bacteria.

Store-bought vs. homemade pesto

Italians will be the first to tell you there's no comparison between store-bought and homemade pesto sauce.
Pesto is a delicate sauce that’s best consumed fresh, as its flavor and quality can deteriorate quickly, becoming bitter and dull as the enzymes released from basil oxidize.
To help extend pesto’s shelf life, store-bought versions often contain preservatives and additives that can negatively impact the flavor and quality of the sauce and may harm your health.
Additionally, many store-bought pestos will substitute critical ingredients, such as extra virgin olive oil (EVOO), cheese, or fresh garlic, with cheaper alternatives or omit them entirely, leading to a bland or unpalatable flavor and a significantly lower nutritional value.

How to choose the best store-bought pesto sauce

Homemade pesto sauce is always preferred, but if you don't have time to make it, the best premade pestos can often be found in the refrigerated section.
Look for pestos that don't contain artificial preservatives or low-quality ingredients, such as sunflower oil or potato flakes. Instead, opt for certified organic and non-GMO products that use high-quality oil and real cheese sourced from grass-fed and pasture cows.

Keto-friendly pesto recipes

If you're looking for a way to add extra flavor to your keto meals, look no further than pesto. Chicken, fish, steak, and most vegetables pair exceptionally well with this tasty and versatile sauce.
Here are some delicious keto-friendly pesto recipes:

• Sun-dried tomato pesto dip
• Vegan keto pine nut pesto
• Vegan mint pesto and veggie bowl
• Keto creamy basil sausage casserole
• Macadamia nut and parsley pesto vegan bowl

To complete your pesto experience, try experimenting with keto pasta recipes.
Zucchini noodles, keto gnocchi, and keto egg noodles are excellent low-carb pasta alternatives that work well with keto pesto sauce.

Tips to make the best pesto sauce

Here are some tips on how to choose the best ingredient to make a nutritious and flavorful pesto at home.

Parmesan cheese

Opt for authentic Parmigiano Reggiano, an Italian staple that’s been in production for over 900 years.
Known for its rich, nutty flavor and granular texture, Parmigiano Reggiano undergoes a meticulous aging process and adheres to stringent production standards, ensuring its authenticity and superior quality.
The Parmigiano Reggiano standard guidelines underscore a commitment to natural production, prohibiting additives and ensuring cows are fed local forage.
This approach not only guarantees the cheese's premium taste but also preserves essential nutrients and probiotics.

Olive oil

Select only pure cold-pressed EVOO. Many olive oils on the market are diluted with cheaper oils that compromise flavor and can introduce harmful ingredients that may negatively impact your health.
In addition, evidence published in the Asia Pacific Journal of Clinical Nutrition summarizes, "phenolic content of olive oil is reduced by chemical extraction and refining."
By prioritizing cold-pressed EVOO, you ensure your olive oil is rich in flavor and health-promoting properties.

Fresh Genovese basil

Harvested during early growth stages to ensure optimal flavor, Genovese basil is the prime choice for making basil pesto.
As Dr. Berg explains, "Basil has some amazing health benefits. It’s loaded with vitamin K, manganese, and flavonoids, which can help support healthy bones, blood clotting, and skeletal health while offering potent anti-inflammatory properties.”

This is my first reddit post, although I have been a long time lurker of many subreddits. I am 23 years old and an only child. I am not a native english speaker, so please forgive any weird formatting or any spelling/grammar mistakes.
As the title states, my mom died ... and I am currently writing this to try and process this whole situation. I've tried to section all the paragraphs in chronological order, to make reading easier. Sorry for the extremely long post - I just needed to get it all out.
We only just celebrated her 60th birthday back in february. She did all the cooking, cleaning and planning without any trouble - even down to picking out the perfect napkins and flowers for her white and gold theme.
My mother was without a job. She had been jobless for almost 2 years now, after she was fired from her old cleaning job due to frequent sick days because of stomach cramps and pain. She was seen by a doctor back in 2022 for her stomach aches, and they found no physical cause - hence why we concluded it must've been due to stress. The stress and stomach pains subsided after she'd been fired. So we thought no more of it.
In march she was doing a 4-week internship in a local supermarket to see if she might've been a good fit for a permanent paid position. This is common practice for unemployeed people here in Denmark.
My mother started having stomach pains again during this internship, soon followed by back pains as well. She figured this was due to her spending most of the day sitting as a cashier in an uncomfortable position. My mother wasn't very tall, so she had trouble reaching the floor pedals that control the cashier conveyer belt.
In the beginning of april, she went to the doctor. Her stomach and back pains hadn't gone away although the internship was over. Her doctor also concluded it was most likely due to her uncomfortable working position, and that it would pass in a few weeks time. The doctor did some bloodwork, and found that she was severely lacking vitamin D, but nothing else seemed concerning at the time.
In the middle of april, her pains had only gotten worse, and she went to the doctor again. Her doctor did more bloodwork, and did a phisycal exam of my mothers stomach. Her doctor ordered a CT scan to check for anything serious.
19th of april. I accompany my mother to the hospital for her CT scan. We get told that we'll have the results in a week or so. My mother is not looking good when I pick her up at the bus station. She is more pale than usual, and has trouble walking at her usual pace.
23th of april. My mother received a referral to a meeting at the hospital with a doctor and nurse, to discuss the results of the CT scan. This referral is sent from the hospitals cancer department. My mother and I speak on the phone, she is concerned, but I tell her that this type of referral must just be standard pratice, and that she shouldn't worry untill we have spoken with the doctor. I cried that night.
25th of april. The day before her meeting with the doctor, I received a phone call from my mother. She tells me that she had fallen while at home, but that I shouldn't worry. I, of course, worry.
I pack my things and leave for my mothers house, I live an hour away by bus. When I finally arrive my mother seems okay-ish, but the house is another story. My mother is normally known for being a clean freak, and her house has always been clean and organized, But it wasn't anymore.
Her kitchen was a mess, and the dishwasher hadn't been empited or loaded for at least two weeks. Her bathroom is even worse, and I won't even begin to describe the state of the toilet it self. It is a sight that will horrify me for the rest of my life. I cleaned everything, while my mother rested.
My mother had also started sleeping on the guest bed, saying her own was too uncomfortable for her.
While cleaning the bathroom, my mother wakes up. Despite her state, she says she wants to help. But before I can even tell her no, my mother has another fall. Her legs essentially just crumble beneath her, and she falls backwards and lands head first on the floor. We argue back and forth about calling an ambulance, but she refuses to let me - so I don't, even though I should have. I guess I still respected my moms authority too much.
My mother lives alone, as my parents are divorced (they are very good friends though). My mother refuses to let me call my dad and tell him about this whole situation. She is stubborn and too proud to admit defeat.
26th of april. We take a taxi to the hospital. The taxi driver has a help my mother into the car. During the carride my mother says very little, but seems slightly delirious and very tired. When we arrive at the hospital, I quickly borrow a hospital wheelchair for my mother. She is almost unable to walk unassisted at this point.
After waiting for a while in the waiting area, a nurse comes and guides us to a meeting room. My mother is very tired at this point, and still delirious, and I have to handle most of the conversation with the doctor.
The CT scan results showed Pancreatic cancer. The cancer had already spread to her liver and abdomial cavity.
I had read about this cancer a few days prior, trying to figure out what was wrong with my mother. I knew what this meant, and I knew that it was effectively a death sentence. The doctor told us that an operation was out of the question, since the cancer had already spread. And due to the clearly weak state of my mothers health, chemo would also not be offered, as it would finish her.
I told the doctor of her two falls and the state of her home, and that she would not be safe on her own. The doctor had her admitted to a nearby bed department for stomach- and gastrointestinal surgery patients.
The hospital did a ton of bloodwork on my mother when she got admitted, and everything was off. All numbers were either too high or dangerously low. My mothers health was in fact so bad, that I was told she was a heart attack risk. I was also told that if a heart attack happened, she would not be brought back - as it would only prolong a very short and painful life.
I called my dad.
27th of april. My mother slept most of the day.
28th of april. My mother had another fall during the night, trying to get to the bathroom.
29th of april. My dad shows up to the hospital. He wasn't able to get off work until now, as he works in the other end of the country. He is shocked to see my mother in this state. We are told once again by a different doctor that nothing can be done. They are looking into getting her a spot at a nearby hospice.
The rest of the remaining week is spent in hospital. My dad and I are by my mothers side every day. She doesn't leave her hospital room, apart from a few times a day for a smoke break outside. My dad and I take her outside in a wheelchair, which she needs help to get in and out of.
Her bloodwork is showing some slight improvements, but she is still having trouble with infections and receives a lot of antibiotics. She eats like a mouse, but drinks a lot of fluids.
My mother is often very confused or tired most days. She gets referred for an MR scan, to see if the cancer has spread to her brain, or if one of her falls has caused permanent damage. Lucikly the MR scan shows that nothing is wrong with her brain.
She gets confused about her diagnosis a few times, thinking that she had brain cancer instead due to the MR scan. I have to remind her a couple times about what the doctor actually said.
6th of may. My mother seems to have stabilized somewhat so my dad has gone back to work.
7th of may. I get told by the hospital staff that my mother is to be transferred to a different hospital, which is one hour away. I become very upset by this news, and unfortunately yell at one of my mothers nurses in frustration. I yell at her that It'll be harder for me to get to my mother in time if something were to happen. I am ashamed of this childish behavior, as the transfer was the best desicion for my mother in hindsight.
I leave with my mother as we get transferred to the new hospital and their department of palliative care.
I am very ashamed by my behavior to my mothers old nurse, as this department for palliative care was truly the best place for my mother. She seemed very satisfied and happy to have been transferred. They have a large garden with wild flowers, and lovely staff. And my mother got a much bigger room all to herself. She also meets with their physical therapist, who helps my mother relieve some of her pain.
My mother and I have dinner together in the evening in her hospital room. My mom is her old self, although with some delayed speaking. I unfortunately have to rush a bit when leaving, as to not miss my bus home, so I quickly say goodbye to her and leave.
8th of may. In the morning on my way to the new hospital, I received a phone call from her new doctor. My mothers liver has suddenly started to fail due to the cancer. When I arrive, she is asleep. I am told she wont wake up again.
I called my dad, but he wont arrive until the evening, due to the distance from his workplace.
I spend most of the day in my mothers hospital room, listening to her sleep. She occasionally attempts to cough in her sleep, but it mainly just sounds like yells. It is terrifying. The nurses give her pain medication and some sleep medication to help her body relax.
My dad arrives in the late evening. We drive to my mothers house and stay the night there. We spend most of the late evening looking at pictures and scrapbooks of my mother, and packing a bag with clothes for her, for when she passes.
When prepareing the guest bed for my dad, we find a blanket that my mother slept on. It is stained, matching the previous state of the bathroom. We throw the blanket out.
9th of may. Mom is sleeping. Dad and I spend the day at the hospital, but we don't sit in her hospital room. It is too eerie and uncomfortable. We check on her occassionally. Towards the evening, her breathing becomes slightly more rapid and quick. But the nurses tell us to go home. There is no reason for us to sit by her side during the night - as it'll only make it worse for us.
10th of may. I wake at 6.12 am to my phone ringing. It is a nurse. My mother has passed away in her sleep at 6.05 that morning due to liver failure. My dad and I drive to the hospital. I am the first to see her body after the nurses prepared and dressed it in the clothing we picked.
(warning: the following paragraph may be slightly upsetting to some readers)
It it eerie and uncomfortable to see my mother like this. A symptom of pancreatic and liver cancers is that your skin will yellow. Something that I hadn't noticed in my mother till now. I cant help but think that she looks like a wax doll, although I feel horrible for thinking it. I finally touch her hand, after gathering the courage to, almost like I am afraid to distrub her. Her hands are cold, and only get colder as I sit by her side. I am supposed to say my goodbyes to her, and tell her how much she means to me, but in this moment I am speechless. I can't say anything, even on my mothers deathbed. I feels wrong to speak to a corpse. I should've said those things while she could hear them instead. I kiss her forehead before I leave the room.
17th of may. Funeral. The church and casket was beautifully decorated with colorful flowers, like my mother had requested. She didn't want anything white or depressing. I cried all the way through the funeral service, stopping only when it was time to carry the casket out. My dad on the left side, and me on the right, and some other family members behind us. Purple rain by Prince was played on the church piano as we carried the casket. I knew the casket would be heavy, but nothing prepared me for the sheer weight of that thing.
21th of may. Today. I don't really know what to think of my mothers death. Some days I almost forget that shes gone or that all this has been happening, until something reminds me of it.
In a way, I am thankful. Of course I didn't want my mother to die, but I'm glad that her suffering wasn't prolonged for months while she slowly withered away to cancer. And I'm thankful that my mother didn't live to suffer from alzheimers, like her own mother. And I am glad that if anything, my mothers death has brought my dad and I closer.
But at the same time, I am angry that she didn't get to live more of her life. She was only 60 years old, and should have had 20 more years at least. If she at least was 70, it might've been easier to lose her but I doubt it.
I think mostly of all the things she will miss out on, which saddens me the most. I am 23 and my mother wont get to see most of my life or my achivements. If I have kids, she'll never meet them, and she I get married, she'll never see it. My 24th birthday is coming up soon, and I don't know how I'll handle that day without my mother for the first time - or christmas for that matter.
I want my mom.

MALVERN, Pa., May 21, 2024 (GLOBE NEWSWIRE) -- Annovis Bio, Inc. (NYSE: ANVS) (“Annovis” or the “Company”), a clinical-stage drug platform company developing novel therapies for neurodegenerative diseases, announced the publication of a new article focused on the comparison of pharmacokinetic profiles of Posiphen (or buntanetap) across different species in a peer-reviewed journal Biomolecules as part of the Special Issue: Role of Amyloid Protein in Neurological Diseases.
“This publication is a testament to many years of research at Annovis. While we have conducted numerous studies to advance our Posiphen pipeline, this is the first systematic and comprehensive comparison in multiple animal and human samples," says Maria Maccecchini, Ph.D., Founder, President, and CEO of Annovis. "Consolidating all this data into one publication offers a more holistic view of Posiphen, enhancing our understanding of its mechanisms.”
Title: Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human
Summary: This article synthesizes findings from various preclinical and clinical studies on Posiphen's absorption and metabolism from mice, rats, dogs, and humans. The aim was to better understand the differences in the drug’s pharmacokinetic behavior, identify which animal models most closely mimic human responses, and explore the potential clinical implications of these variations.
Key highlights:

• Posiphen quickly reaches peak concentration in plasma, followed by high absorption in the brain and cerebrospinal fluid (CSF).
• Posiphen metabolizes into two primary metabolites: N1-norposiphen and N8-norposiphen.
• Both Posiphen and its metabolites exhibit rapid clearance in animal models and human subjects; however, in the CSF or the brain, the drug stays longer.
• Posiphen's absorption, distribution, metabolism, and excretion are similar in healthy volunteers and patients with Alzheimer’s and Parkinson’s diseases.

The article can be found on the journal’s website via the link.
ARTICLE: https://www.mdpi.com/2218-273X/14/5/582
FULL RELEASE: https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?airportNewsID=98e152c8-60ff-4d1c-9f55-8dbc9fbfa988

My understanding is that vitamin B9 impacts the process of DNA methylation. And that this process has to do with genes getting "turned on and off"; it's epigenetics. If you have dysregulated or messed-up DNA methylation then, genes are getting "turned on and off" in a harmful and disorganized way throughout your body, correct?
But what does this really mean and how does this actually play out? I would love to read something about that topic.
Is DNA methylation happening on a very rapid "timescale" such that taking a vitamin-B9 supplement could induce (within, say, 1 minute? or 5 minutes?) changes in the methylation process that would cause actual changes in your body? What changes in your body could occur within 1 minute...or 5 minutes or 10 minutes or 30 minutes...through changes in the process of DNA methylation?
If you take a vitamin-B9 pill and then (after a few minutes) your GI system makes some noises and becomes more active, is it possible that those noises and that activity are related to DNA methylation? Or could DNA methylation never induce the noises and the activity?
See here:
https://www.ingentaconnect.com/content/ben/cdm/2005/00000006/00000001/art00006

Advances in molecular biology greatly contributed, in the past decades, to a deeper understanding of the role of gene function in disease development. Environmental as well as nutritional factors are now well acknowledged to interact with the individual genetic background for the development of several diseases, including cancer, cardiovascular disease, and neurodegenerative diseases. The precise mechanisms of such gene-nutrient interactions, however, are not fully elucidated yet. Many micronutrients and vitamins are crucial in regulating mechanisms of DNA metabolism. Indeed, folate has been most extensively investigated for its unique function as mediator for the transfer of one-carbon moieties for nucleotide synthesis / repair and biological methylation. Cell culture, animal, and human studies, clearly demonstrated that folate deficiency induces disruption of DNA synthesis / repair pathways as well as DNA methylation anomalies. Remarkably, a gene-nutrient interaction between folate status and a polymorphism in methylenetetrahydrofolate reductase gene has been reported to modulate genomic DNA methylation. This observation suggests that the interaction between a nutritional status and a mutant genotype may modulate gene expression through DNA methylation, especially when such polymorphism affects a key enzyme in one-carbon metabolism and limits the methyl supply. DNA methylation, both genome-wide and gene-specific, is of particular interest for the study of aging, cancer, and other pathologic conditions, because it affects gene expression without permanent alterations in the DNA sequence such as mutations or allele deletions. Understanding the patterns of DNA methylation through the interaction with nutrients is a critical issue, not only to provide pathophysiological explanations of a disease state, but also to identify individuals at-risk to conduct targeted diet-based interventions.

I think we tend to think of genetics as this immutable thing and therefore we would be surprised if the process of DNA methylation could induce changes in our bodies within 1 or 5 or 10 or 30 minutes.

The liver is one of the most vital organs in your body, playing a crucial role in maintaining your overall health. Located in the upper right quadrant of your abdomen, the liver is responsible for various essential functions, including detoxification, protein synthesis, and production of biochemicals necessary for digestion. Understanding the importance of liver health and knowing how to care for it can significantly enhance your well-being.
Functions of the Liver
Detoxification: The liver detoxifies various metabolites, synthesizes proteins, and produces biochemicals necessary for digestion. It filters out toxins from the blood, ensuring that harmful substances are eliminated from the body.
Metabolism: The liver plays a crucial role in metabolism, including the regulation of glycogen storage, decomposition of red blood cells, and hormone production. It helps convert nutrients from your diet into essential blood components.
Production of Bile: Bile produced by the liver is essential for the digestion and absorption of fats and fat-soluble vitamins in the small intestine.
Storage: The liver stores vital nutrients, such as vitamins and minerals (iron and copper), and releases them when needed.
Keeping Your Liver Healthy
Maintaining liver health is crucial for your overall well-being. Here are some tips to keep your liver functioning optimally:
Healthy Diet: Eating a balanced diet rich in fruits, vegetables, whole grains, and lean proteins can support liver health. Avoid excessive intake of fatty foods, sugar, and alcohol.
Regular Exercise: Physical activity helps maintain a healthy weight, reducing the risk of non-alcoholic fatty liver disease (NAFLD).
Hydration: Drinking plenty of water helps the liver function efficiently, aiding in detoxification processes.
Avoid Alcohol and Drugs: Excessive alcohol consumption and drug abuse can lead to liver damage. It’s crucial to limit alcohol intake and avoid illicit substances.
Regular Check-Ups: Regular medical check-ups can help detect liver issues early. The Best Multispeciality Hospital in Ghaziabad, like Sanjeevani Clinic, offers comprehensive healthcare services to monitor and maintain your liver health.
Liver Health and Overall Well-being
A healthy liver contributes significantly to your overall health. When your liver functions properly, you’re more likely to experience better energy levels, improved digestion, and a stronger immune system. Moreover, liver health is closely linked to other health aspects, such as ENT problems. For instance, issues like ear infections, sinusitis, and throat problems can sometimes be related to broader systemic health issues, including liver function.
If you're experiencing ENT problems, it's advisable to consult the Best ENT Specialist near me at Sanjeevani Clinic in Ghaziabad. The clinic offers top-notch medical treatment and healthcare services, ensuring comprehensive care for conditions like ear infections and sinusitis.
Sanjeevani Clinic: Your Health Partner
At Sanjeevani Clinic, we prioritize your health and well-being. As the Best Hospital in Ghaziabad, we provide a wide range of medical services, including the Best Pathology Lab in Ghaziabad for accurate diagnostic tests. Our healthcare professionals are dedicated to delivering high-quality medical care and promoting health awareness in the community.
In conclusion, taking care of your liver is essential for maintaining overall health. By adopting healthy lifestyle habits and seeking regular medical care from trusted healthcare providers like Sanjeevani Clinic, you can ensure your liver remains in optimal condition. Remember, your liver is key to keeping you healthy, so take proactive steps today to support its function and stay healthy. For all your healthcare needs, including ENTCare, trust the expertise of Sanjeevani Clinic in Ghaziabad.
Sanjeevani Multispeciality Clinic
Address: SE-2 Basement Floor, Hapur Rd, near Indian Oil Petrol Pump, E Block, Shastri Nagar, Ghaziabad, Uttar Pradesh 201002
Phone: 088822 40830

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I'm 28 and just found out I inherited diseases from both parents which predispose me to high cholesterol. Such a stitch up.
I've always been thin, and never wanted to take it for granted... so naturally, always ate as much fat as I could. KFC three times a week, whole blocks of choccy for dinner, cream in my coffee, roast dinners, snacks. As long as I was taking my vitamins and keeping my calories reasonable I thought why not? I felt super healthy, I was thin, and I was making the most of it.
WELL I just found out I have hypothyroidism (thx mum) and high cholesterol (thx dad- he has hereditary high cholesterol and severe heart disease). So I gotta change.
So I've been eating low saturated fat for three days and I'm FAMISHED. I love veggies and salads as much as the next person but I can't shake this insatiable hunger.
There are a handful of foods which do satiate me but they're in the "somewhat naughty" category. So my first question is this. Which of these is the lesser of three evils?: - Roast potatos in olive oil - Tuna sandwich in multigrain bread - scrambled eggs with Proactiv spread on bread
Could I still eat these every day and be okay or is that self destructive?
Second question- Am I addicted to fat and can I shake this feeling?
I'm intolerant to nuts and avocados which is another fkn stitch up, any other healthy fat recommendations would be great. :) Thanks if you read this far!!