2024.05.15 23:56 aubrey_ann Mom Juggling latest post
2024.05.13 12:34 AccutaneEffectsInfo How Accutane Changes Your Brain: Dopamine & Cell Death
https://secondlifeguide.com/2024/01/07/accutane-effects-on-the-brain/ submitted by AccutaneEffectsInfo to AccutaneRecovery [link] [comments] INTRODUCTIONAccutane, also known by its generic name isotretinoin, is a widely used medication primarily prescribed for the treatment of severe acne. Over the years, its effectiveness in treating severe acne has been well-documented, earning it a reputation as a potent solution where other treatments fail. However, alongside its efficacy in treating acne, it has also been associated with a range of potential side effects – particularly in relation to the brain.The extent of its psychological impact particularly came to prominence during a 2015 murder trial, where attorneys argued that a 15-year-old flew into a homicidal psychosis on account of his treatment by the acne drug. [1] Though this may seem farfetched it isn’t an isolated incident, and the connection between Vitamin A and neurological disorders is one with long historical precedent. The effects of overexposure to Vitamin A on the central nervous system were first documented in 1856 by Elisha Kane, an Artic explorer who suffered dramatic changes in mood and temperament after ingesting polar bear liver. The many symptoms of Accutane treatment significantly overlap with those of Hypervitaminosis A, given that Accutane exerts its therapeutic effects through the primary metabolite of Vitamin A: Retinoic acid. However, unlike overexposure to Vitamin A, Isotretinoin is able to avoid xenobiotic responses that metabolise excessive retinoic acid, allowing for an even greater intracellular accumulation.[2] A meta-analysis of 25 randomised controlled trials found that neurological symptoms were amongst the most common adverse effects associated with Accutane treatment – with 24% suffering extreme fatigue and 10% complaining of significant changes in mood and personality. [3] Aside from the many case reports, there’s a good neuroanatomical basis for believing that retinoids are fundamental to cognition and mood. The enzymes that locally synthesise retinoic acid are highly expressed in regions of the brain that are rich in dopamine, such as the mesolimbic. [4] Dopamine is the neurotransmitter associated with feelings of reward, excitement and pleasure; however dysregulation of dopaminergic system can lead to mania and psychosis. The exact role retinoic acid plays in regulating dopamine is yet to be fully understood, but the evidence shows the two systems are deeply intertwined*.* [5][6] STEM CELLS AND RETINOIDS:Beta-catenin is a multifunctional protein that serves as a key regulator in many cellular processes, but most pertinently in stem cell proliferation. Many organs throughout the body rely on a pool of stem cells to draw upon for tissue repair and maintenance, such as the skin.Beta-catenin signalling is regulated by a ‘destruction complex’, which continuously marks the protein for destruction. When it is unbound from the destruction complex it translocates into the nuclei of cells to signal for the proliferation (increase the number) of stem cells in these given tissues. When beta-catenin is repressed by enhancing the action of the destruction complex, the stem cells in these tissues undergo a process of specialisation called differentiation**.** [7] https://preview.redd.it/efv0auyy860d1.png?width=1221&format=png&auto=webp&s=f980b81cced156a795193957fa3e6b04a788c21a Final stem cell differentiation.svg), This file is licensed under the Creative Commons Attribution-Share Alike 4.0 International license. This process can’t be reversed, and the stem cell pool must replenish in order to preserve future tissue reparative properties. Retinoids are differentiating agents, that repress beta-catenin by enhancing the action of the destruction complex and thus inhibiting stem cell proliferation. A careful equilibrium must be maintained to ensure that stem cells don’t aberrantly differentiate. The consequences of disrupting this balance are most disturbingly evidence by the foetuses of mothers exposed to high levels of vitamin A, as foetal development is reliant on the proliferation of embryonic stem cells. These foetuses typically fail to develop normal limbs if they survive gestation at all. [8] Whilst beta-catenin signalling is regulated by retinoids, retinoid signalling is in turn regulating by beta-catenin feedback through the ALDH (aldehyde dehydrogenase) enzymes. ALDH enzymes play a key role in synthesising retinoids, and a regulated by beta-catenin. High levels of beta-catenin trigger an enhance ALDH activity, which in turn leads to greater retinoid synthesis and therefore suppression of beta-catenin. Alternatively high levels of retinoid signalling, as in during Accutane treatment, leads to suppression of beta-catenin and in turn ALDH activity. However, ALDH enzymes don’t exclusively serve to synthesise retinoids, they also play a vital detoxifying role in metabolising toxic acetaldehydes and lipid peroxides. [9] ACCUTANE REDUCES CORTICAL BRAIN ACTIVITYThere is a mountain of evidence within the scientific literature that points to the diverse and profound effects of Accutane treatment on the brain. The most striking of this evidence comes from brain imaging of patients being treated with Accutane, which indicated a 21% reduction in activity in the orbitofrontal cortex. [10]The frontal cortex is the region of the brain most developed in humans as compared to other animals and is responsible for higher cognitive processing. The researchers also identified that this reduction in activity was accompanied by headaches, with the severity of the headaches correlating with the degree of inhibition. The findings of this study corroborate the evidence for Isotretinoin inhibiting new nerve growth in the brain, and even directly causing apoptosis (cell death) of neurons. [11] The prevailing theory for depression is that it is a consequence of reduced neurogenesis (neuronal cell growth), which can be mitigated by neurogenic compounds. [12] It is therefore reasonable to connect the evidence of Accutane induced depression to these neurogenic effects. As previously established, beta-catenin signalling is needed to maintain stem cell populations in the many tissues that undergo continual growth and reparation throughout adulthood. The brain, and in particular the hippocampus, is one such region. The hippocampus is essential for the generation of episodic and spatial memory. Neuroplasticity in the hippocampus is needed to form new memories throughout adulthood. It’s been found that when beta-catenin is ablated in hippocampal cell cultures, the synaptic strength is diminished. Neurons lacking beta-catenin became thin and spindly, with reduced amplitude of spontaneous glutamatergic currents. [13] Conversely, enhancing beta-catenin signalling in transgenic mice allowed for greater neuronal growth and even enlarged brains on account of the increase in neural stem cell populations. [14] Understanding the role of beta-catenin is key to explaining the evidence for Accutane inhibiting new cell growth in the hippocampus. [15] BETA-CATENIN AND NEURONAL DEATHNotably the neurological role of beta-catenin isn’t confined to the hippocampus, as it also greatly impacts synaptic activity in two other regions: the hypothalamus and the amygdala. The hypothalamus is a part of the limbic system that controls the release of hormones involved in diverse processes including facilitating sexual responses, hunger, and circadian rhythms. Hypothalamic cells are also subject to both growth and regulation by beta-catenin which can be guided in particular by oestradiol, which activates the PI3K/Akt pathway.Poignantly, this action of oestradiol is the exact opposite of the mechanism of action by which Accutane suppresses beta-catenin. The importance of oestradiol is especially relevant for woman with respect to the oestrous cycle, and the periodic changes it induces on synaptic structures. [16] Given this evidence, it is perhaps unsurprising that hypothalamic cells (along with hippocampal cells) are amongst the neuronal cells most vulnerable to apoptosis (cell death) in response to retinoic acid exposure. [17] Another structure within the limbic system is the amygdala, which consists of two clusters of nuclei in the centre of the brain and plays a pivotal role in regulating memory, emotional response and feelings of reward and pleasure. Like the hypothalamus, the amygdala also appears to significantly influenced by beta-catenin. There’s evidence that beta-catenin is needed for the transfer of newly formed memory into long term memory, and specific deletion of beta-catenin prevented this memory consolidation. [18] Furthermore, researchers have been able to trigger dysregulation of the amygdala of rats by applying retinoic acid, resulting in heightened fear and anxiety responses. ALDH: ‘DETOX’ AND DOPAMINEThe Aldehyde Dehydrogenase (ALDH) family of enzymes plays a pivotal role in the metabolism of aldehydes, which are a type of reactive molecule within biological systems. It’s a diverse family of enzymes consisting of many isoforms with wide ranging targets contributing to a variety of physiological processes. In particular, ALDH enzymes are known for their critical detoxifying function in oxidizing aldehydes to their corresponding carboxylic acids.Given that ALDH enzymes have been implicated in cellular protection against oxidative stress, they subsequently play a role in the development of a number of diseases, in particular neurodegenerative disorders. They have a particular relevance to the metabolism of retinoids, as they catalyse the conversion of retinol to retinoic acid locally within tissues. [26] As discussed previously, ALDH activity is regulated by beta-catenin in a negative feedback loop. The administration of Isotretinoin marks these enzymes for downregulation by interrupting this feedback loop and suppressing ALDH activity. [27] Long term application of retinoic acid downregulates these enzymes through post-translational modifications, potentially giving an epigenetic basis for the lasting nature of Post Accutane Syndrome. [28] The adverse effects of suppressed ALDH activity are potentially very broad given the diversity of roles they play outside of metabolising retinoids. One of the best attested lasting adverse effects of Isotretinoin treatment is permanent night blindness. Researchers concluded that this is a consequence of the suppression a particular member of the ALDH family, RDH11, which serves to recycle rhodopsins in the retina. [29] THE LINK TO PARKINSONSIt’s hard to overstate both the importance and diversity of ALDH activity in the body, from the production of neurosteroids, to metabolism of alcohol to detoxification, but the particular focus of this article is their role in neurological functioning and how it relates to the adverse effects of Isotretinoin treatment. The first indication that play an important neurological role that ALDH isoforms are expressed in regions of the brain rich in dopamine. [30]For example the enzyme retinaldehyde dehydrogenase 1 (RALDH1) is present in the dopaminergic terminals that innervate the striatum from the ventral tegmental area is necessary for the synthesis of RA in these areas. [31] The previously cited neuroimaging study found that the regions of the brain most rich in dopaminergic activity, such as the midbrain and mesolimbic, experience the greatest reduction in activity during Isotretinoin treatment. This could potentially be explained by the detoxifying role played by ALDH isoforms such as RALDH1 during dopamine transmission, which is likely inhibited by Isotretinoin treatment. The metabolites of dopamine such as DOPAL (3, 4-dihydroxyphenylacetaldehyde) are neurotoxic, but can be metabolised by RALDH1 to protect dopaminergic neurons**. If RALDH1 is inhibited these dopaminergic neurons within the mesolimbic are more susceptible to cell death.** [32] This effect is so profound that ALDH inhibitors are even able to induce Parkinsonian like symptoms, which is a type of Alzheimer’s characterised by the rapid loss of dopaminergic neurons. [33] Additionally, the overaccumulation of toxic dopamine metabolites results in negative feedback to acutely inhibit dopamine neurotransmission. This is why ALDH inhibitors such as Disulfiram can cause a blunted response to stimulants such as amphetamine. [34] Given that dopamine is needed to facilitate feelings of pleasure and, reduced libido is one of the most common complaints of people being treated with Disulfiram, which is a medication used in combatting alcohol addiction. In fact, it is now believed that Disulfiram is effective in treating addiction by blunting feelings of pleasure that drive addictions, through the negative feedback of toxic dopamine metabolites. [35] The evidence for Isotretinoin inhibiting ALDH expression indicates that Disulfiram could potentially serve as an effective analogue for some of the effects of Isotretinoin treatment. |
2024.05.11 03:17 sappynerd Local corruption in Massachusetts towns and cities seems to be a common theme. The Death of Chris McCallum: A Case of Quincy Police Corruption and Negligence
2024.05.04 12:23 drea915 Karen Read murder trial: A guide to the key players you need to know (LINK HAS PICTURES TOO)
2024.04.27 00:59 PanAmFlyer The Anchorage Cottage - Willoughby
https://preview.redd.it/lp8jqa5emwwc1.jpg?width=446&format=pjpg&auto=webp&s=7a0d4b6dc6bb206454b8a2a4742cb5946d2065aa submitted by PanAmFlyer to norfolk [link] [comments] 850 West Ocean View Avenue (originally 830 Chesapeake Bay Avenue) on Norfolk's Willoughby Spit was built in the early 1900s. It was the summer residence of Arunah Otto Lynch and his wife, Viola. Mr Lynch was an attorney with an office on Main Street in Downtown Norfolk. He was also the Commonwealth Attorney for Norfolk County for 26 years, and Treasurer for 9 years. The Lynch's had a primary residence on Victoria Avenue in the Chesterfield Heights neighborhood, but like many families in the days before air conditioning, they kept a cottage at the beach. In those days it was common to give each cottage a unique name and the Lynch's named this cottage "The Anchorage". In the early 1930s, the Cottage was sold to the American Legion Post No 35. Named in memory of Junius F Lynch, it continues in that use today. |
2024.04.25 07:46 hanas_lin Cordish beats out four other bidders to win Petersburg's casino business, but council reaction is muted
2024.04.24 12:37 HashTagFinallyWoke Andra Brown and Xavier Elijah Hudspeth Charged with Home Invasion Robbery of William Irving Moore and blinded Connie Hubbard
2024.04.18 20:08 spoiledrichwhitegirl Article: Jury selection in Karen Read trial not complete after 3rd day as proceedings wrap for week
2024.04.16 03:45 AutoNewspaperAdmin [Local] - Attorneys answer residents' questions about $600 million Norfolk Southern settlement Pgh Post-Gazette
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2024.04.16 03:16 AutoNewsAdmin [Local] - Attorneys answer residents' questions about $600 million Norfolk Southern settlement
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2024.04.11 00:15 AutoNewspaperAdmin [Local] - Attorneys in the Norfolk Southern settlement clarify some details of the payout Pgh Post-Gazette
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2024.04.11 00:06 AutoNewsAdmin [Local] - Attorneys in the Norfolk Southern settlement clarify some details of the payout
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2024.04.09 13:01 FelicitySmoak_ On This Day In Michael Jackson HIStory - April 9th
1974 -The Jackson 5 perform "Let It Be", "Never Can Say Goodbye" and "Dancing Machine" on the Tonight Show with Johnny Carson submitted by FelicitySmoak_ to WhereWasMJToday [link] [comments] https://reddit.com/link/1bzpalb/video/gxqhoee413tc1/player 1975 - The Jackson family returns to the MGM Grand Hotel in Las Vegas for a last series of shows. This time playing 14 nights through April 22nd https://preview.redd.it/oiy6tfk613tc1.jpg?width=1086&format=pjpg&auto=webp&s=2aeebf0673239c86034b058686e655546f0412d0 1984 - Through the 'Brass Ring Society', an organization which fulfills the wishes of terminally ill children, Michael Jackson welcomes 14-year-old David Smithee to his Encino family home. https://preview.redd.it/w92frjy813tc1.jpg?width=199&format=pjpg&auto=webp&s=965b16a60f0e0e2cd1bd089510643cdd4dd21608 Granting Smithee's last wish as he suffered from chronic Cystic Fibrosis. During the afternoon visit, David watches a movie with Michael in his home theater, plays video games and learns how to moonwalk. Of the video games, David later tells a Tulsa Tribune reporter: "I played two games with him and beat him both times"https://preview.redd.it/bzh6ejja13tc1.jpg?width=238&format=pjpg&auto=webp&s=b9c2f8bdd43e6a34be077bb60c84e20b2400b63a The visit was topped off with Jackson giving David the red leather jacket he had worn in the "Beat It" video and a beaded glove he had worn to the American Music Awards, where he collected eight awards. Seven weeks later, Smithee passes away. Michael will remember the boy by dedicating The Jacksons Victory album in his honor. https://preview.redd.it/6xb70f5f13tc1.jpg?width=459&format=pjpg&auto=webp&s=445f8b6af3fb4ddf6a17d98fdddae43e8efb47fa https://preview.redd.it/y471h5rg13tc1.jpg?width=350&format=pjpg&auto=webp&s=3ec589e0c4dca91c819cae01a0b37d61689254bf 1984 -Liza Minnelli accompanies Michael to Swifty Lazar’s (talent agent) Oscar Night Party at Spago but after a short stay, they go on to visit Liza’s father director Vincente Minnelli https://preview.redd.it/9963olkk13tc1.jpg?width=280&format=pjpg&auto=webp&s=d47b7745f23449cae30c37fbc70a62e8c33b7c26 https://preview.redd.it/kt362abn13tc1.jpg?width=617&format=pjpg&auto=webp&s=05d139a426f5c8c3a732640c53c9e4ebf117f8e4 https://preview.redd.it/zvd6zpnp13tc1.jpg?width=280&format=pjpg&auto=webp&s=fafbc6043dcadb21bd4d6ea383d55c9d8daab72f https://preview.redd.it/0p2h8o9t13tc1.jpg?width=788&format=pjpg&auto=webp&s=52f6f1c92468fcc2c8ff85919259d585c4116bcc https://preview.redd.it/b5d2jvju13tc1.jpg?width=1200&format=pjpg&auto=webp&s=8297348901c3c556f3b14b5fe6f7d15aba9f9817 1988- On his Bad World Tour, Michael plays the 2nd of three shows at The Summit (now Lakewood Church Central Campus) in Houston, Texas https://preview.redd.it/tlb4jx8u4atc1.jpg?width=600&format=pjpg&auto=webp&s=e2d205028a3cb5c36a1b2dd78e2a9b2df31ee2a0 1991- Michael & Madonna go to the Spago restaurant in Los Angeles . Michael asks Madonna to do a duet on the song “In The Closet” "In the Closet" was originally conceived as a duet. According to a 1992 interview with British journalist Jonathan Ross, Madonna said she worked on some lyrical ideas for the song but when she presented them to Michael, he decided they were too provocative and they decided not to continue with the project 1992 -“In The Closet” Is released as the 3rd single from the Dangerous album. It peaks at #6 on Hot 100 Billboard and #1 on the R&B chart https://preview.redd.it/e1sp1u5w13tc1.png?width=300&format=png&auto=webp&s=a052c2cfb87e6fc67a4a63f2d1862d5bcb15fd04 https://preview.redd.it/30c2wwex13tc1.jpg?width=1073&format=pjpg&auto=webp&s=f1be87ad8330fe6fdbdb9271952c99efa352ceca https://preview.redd.it/5jih4ic123tc1.jpg?width=1080&format=pjpg&auto=webp&s=d14aa7e14e786bbcd5fdeff5536df926d99def15 1996- Michael is on the cover of tabloids magazine, National Enquirer https://preview.redd.it/wi62omv223tc1.jpg?width=1600&format=pjpg&auto=webp&s=d440ea4cdd30fc193a41e2b184a7b8e31468385d 1998- A Los Angeles Superior Court jury awarded Michael $2.7 million in damages in a defamation-of-character suit against Victor Gutierrez. Michael sued and won with a 9-3 win; the 3 that held out were pushing for Michael to receive more money. The 12 people jury was quoted as saying they wanted to make an example of Victor and send a strong message to the media about erroneous reporting. Thee lawsuit against Victor was over an interview Victor had with Diane Dimond. On 1/9/95, Diane Dimond appeared on The Ken and Barkley Show on KABC -AM radio in which she first stated “there was a 27-minute video of Michael having sex with a minor boy". The boy was said to be Jermaine Jackson’s son Jeremy who was 9 yrs. Both Jermaine and Margaret the child’s parents denied the story. The interviewer even asks Diane if was she 100% sure the videotape existed. Diane replied: “I am as sure as I can be"Diane also alleged that the L.A. District Attorney’s office had reopened its investigation of MJ. Later that evening, (Jan. 9, 1995), Hard Copy ran the same story insinuating the tape did exist, however, Diane was sure to mention she never saw the tape and only believed hee liable source Victor. Michael sued all five for $100 million: Victor, Diane, ABC TV, Hard Copy, and Paramount for perpetuating the slander claim. However, 4 of the cases were dismissed before going to trial because he was unable to prove the other 4 had malicious intent, like Victor who was ordered to stand trial. After the ruling, Victor fled the US to return to Chile where he originally lived and allegedly remained there until MJichael's death. 2001 - Michael, Grace & the kids spend 2 weeks at Teddy Riley’s home in Virginia where he & Michael work on Invincible. He has visited Virginia at least once before while working on Dangerous. Riley, operates the studio Future in Virginia Beach After Michael was spotted at a Barnes & Noble near Pembroke Mall in Virginia Beach, radio station WNVZ-FM (104.5) asked listeners to call in with sightings. Incredibly, someone called up offering the name of the hotel where he was staying, even the specific room number A newsmen from WAVY-TV Channel 10 managed to finagle what a brief encounter with Jackson. "Oh, jeez, I'm sorry. You've been very kind, but I'm not prepared to answer any questions. I'm very sorry," a very Michael-sounding voice told reporter Carter Evans over the phone. "Tell Norfolk I love them, OK?" When they leave Virginia, they go back to NYC and check in to the Plaza Athénée Upper East Side. 2009 - Michael goes to Dr Klein’s in Beverly Hills and he visits the antique store Lladro on Rodeo Drive https://reddit.com/link/1bzpalb/video/0551k29523tc1/player https://preview.redd.it/y58pj2q723tc1.jpg?width=640&format=pjpg&auto=webp&s=d6c4ea5999477df885c4e0fb52c43694ab6c2b42 https://preview.redd.it/i6jesh6923tc1.jpg?width=800&format=pjpg&auto=webp&s=85f79754fbb00f3c07df5fd8dcaf537b32a7633a https://preview.redd.it/ezxws7vb23tc1.jpg?width=736&format=pjpg&auto=webp&s=c4d61be72ccbb3efb987dcb88f76d35b0b36092d https://preview.redd.it/dt7xvbbd23tc1.jpg?width=634&format=pjpg&auto=webp&s=e506f046ee8f79f235592d4e22e58cd636dd223d https://preview.redd.it/1zoiocaf23tc1.jpg?width=275&format=pjpg&auto=webp&s=f7b911959be286b09cecc4f6f61e745358bb1a49 |
2024.03.30 23:34 Nervous-Bullfrog-884 Coupons over Dividends
submitted by Nervous-Bullfrog-884 to amcstock [link] [comments] |
2024.03.26 23:49 PanAmFlyer John Ney Sebrell Home - Circa 1910
https://preview.redd.it/ttvfo8xacrqc1.jpg?width=233&format=pjpg&auto=webp&s=6f42e1c6985eaf73d54c82e959347048a7b56700 submitted by PanAmFlyer to norfolk [link] [comments] 630 Redgate Avenue (originally 106 East Redgate Avenue) was built around 1910 and was the home of John Ney Sebrell, his wife, Bessie, and their sons, John, Jr and Joseph. Mr Sebrell was born in Southampton County, Virginia, in an unincorporated community. The area still known today as Sebrell, after his family. He attended Randolph Macon College, and then University of Virginia Law School and, after passing the bar, he returned home to practice law. He was also elected as the Southampton County Representative to the Virginia General Assembly for two terms. After finishing his terms in the Assembly, he moved to Norfolk and opened law offices in the Seaboard Bank Building in Downtown. Still a politician he ran for and was elected to Norfolk's Common Council, the equivalent of today's City Council, and eventually he served as Norfolk's City Attorney. In the early 1900s, men's clubs were the social connections of the day. Mr Sebrell participated in many of Norfolk's most exclusive organizations. Among others, he was Potentate of The Khedive Temple, a member of the Virginia Club and of The Knights Templar. Mr Sebrell passed away on June 12, 1947 and was laid to rest in Norfolk's historic Elmwood Cemetery on West Princess Anne Road. His wife passed away 4 years later and is interred next to him. |
2024.03.24 18:37 NameIsGermany The Sun Chronicle: State Democrats Gather in Attleboro Emphasizing Importance of November Election
https://www.thesunchronicle.com/news/local_news/state-democrats-gather-in-attleboro-emphasizing-importance-of-november-election/article_98e5e4d0-0348-5a87-a91b-0d6047115142.html After a 4 year hiatus caused by the pandemic, the Attleboro Democratic City Committee held their annual brunch yesterday with a packed crowd at the Portuguese-American Club. 19 democratic candidates from the local area spoke to about 130 attendees about the upcoming election. Secretary of State William Galvin spoke to identify the value of mail-in voting. He also warned that there is "not a lot of enthusiasm" for the two presidential candidates so campaigners will have to work hard to turn out the vote this November. Kevin Kalkut of Norfolk said no Democrat has won the state representing district he is running in for 30 years years. But, former Norton Selectman Mike O'Toole said he is running for state representative in a district that has been Republican for 45 years. State Rep. Adam Scanlon, A North Attleboro Rep who also represents Attleboro's North Corner, claimed that until he won his seat, it had been held by a Republican since the American Civil War. State Sen. Becca Rausch, who previously represented Attleboro, said that after several years of steady gains in the number of women in the Legislature, she's found that a large number of the women are suddenly leaving politics. State Sen. Paul Feeney, our current state senator, had the most enthusiastic speech that drew the most applause. He spoke about affordable housing, health care, and support for labor unions. State Rep. Jim Hawkins, the Rep for most of Attleboro, talked about how a homeless shelter he has been working on should open by September. Candidates for governor's council, clerk of courts, district attorney, register of deeds, register of probate also spoke. Bristol County Sheriff Paul Heroux also spoke in one of his first local public addresses since leaving his post as Attleboro mayor. After the event, former party Chairman Steve Grossman treated everyone to ice cream, as he has for the past 15 meetings. submitted by NameIsGermany to AttleboroMA [link] [comments] |
2024.03.23 06:59 JohnPColby Bulldog and Bull Terrier School Attacks (1880 to 1934)
This is a post about attacks on children at school, or on the way to or from school (a tale as old as time for these "nanny dogs") submitted by JohnPColby to BanPitBulls [link] [comments] Disclaimer: Please see my explanation on the use of the terms "bulldog", "bull terrier" and "brindle bulldog" here 1880-4-12Harrisburg, PennsylvaniaSeveral school children injured (Annie Vandling, Josie Shissler, [unknown] Olsten, Maggie Westaffer, Lizzie Gorden, Alice Orth) A bulldog broke its chain to follow its owner's child to school. When the teacher tried to put it out of a classroom it became vicious, injuring several children, some severely. Annie Vandling: severe wounds inflicted. Josie Shissler: bitten in the face. Olsten: bitten in the nose. Maggie Westaffer: left hand lacerated. Lizzie Gorden: both legs very severely lacerated. Alice Orth: very badly bitten on the cheek and other parts of the face. Other children: more or less injured. 1897-3-6Philadelphia, Pennsylvania14-year-old girl and two other girls injured (Susan Heller, Bessie Zerfoss, Pable Pusey) 3 young girls attacked in a schoolyard by a vicious bulldog, who broke away from the woman walking it past a nearby drug store, and suddenly attacked the girls Susan Heller: flesh torn from right thigh, palm of right hand and arm terribly lacerated, and lips and left side of face torn. In a critical condition. Bessie Zerfoss: left arm lacerated in two places. Pable Pusey: finger lacerated. 1897-4-15https://preview.redd.it/ob7vi4p6q0qc1.jpg?width=1500&format=pjpg&auto=webp&s=2dc728048bfe64dff87c8e2d9c7dd12b4f836e32San Francisco, California 8-year-old girl injured (Valentine Goody) School girl on the way to school attacked by a bulldog/bull terrier which seized her thigh and shook her like a rat. A policeman leaped on the dog and gripped it around the neck and it let go of the girl, only to try to attack another child. Bitten in the thigh 1900-9-22Norfolk, VirginiaFive male students injured (Vincent Davis, Livius Old, Robert Adkinson, James Cherry, George Keefe) Bull terrier ran into a public school and attacked five male pupils, biting four and biting the fifth severely. Two of the teachers seized the dog by the throat and choked it until it leg go off the boy. 4 students: bitten in the leg. George Keefe: very badly bitten. 1902-10-31Cedar Rapids, Iowa9-year-old boy injured (Glennie Williams) 9-year-old boy on the way home from school terribly bitten by two bull terriers. He managed to save himself by dragging himself onto a hitching post. A nearby telephone man beat the dogs away with great difficulty. Legs bitten and lacerated in a horrible manner; bitten eight or ten times, will be unable to walk for some time 1908-4-6Atlanta City, New Jersey3 young boys injured (William Harris, Edward Ward, Louis Bird) Three boys bitten by a vicious bull terrier. Other children were saved by their Sunday school teachers, who drove back the dogs with sticks and rules until a police officer was able to shoot it. 3 boys bitten and treated at a hospital 1909-5-20Cleveland, Ohio6 school children injured (Arthur Benroth, Walter Kazimore, Frank Zolenik, Herbert Deimm, John Koliat, Perry Breising) Six school children bit by a vicious bulldog which invaded the playground. The children who were bit were boys who went to the rescue of other children being chased and attacked by the dog. Hands and legs lacerated 1909-5-27Brooklyn, New York10-year-old girl, 17-year-old girl injured (Marie and Nettie Notaro) Bulldog attacked a 10-year-old girl on the way to school, after it broke its leash. Her old sister attempted to beat the dog away and was bitten. A man struck the animal with an iron bar, stunning it, then a policeman shot it. The dog had bitten nearly a dozen children in the past 3 months. Marie Notaro: Terribly bitten, with nearly 30 wounds in her shoulders, back, hip, arms, and legs; in a critical condition. Nettie Notaro: Bitten 1909-12-2San Diego, California4 young girls ranging in age from 8 to 13 years injured (names unknown) Four young girls attacked at school by a savage bulldog All four girls seriously injured 1914-5-6Akron, Ohio5 school children injured (Alexander Walder, Helen Barr, Harding Christ, Wendell Loomis, Ralph Asor) Five children bitten when a maddened bulldog entered a school. It first bit students in a classroom, then bit two more children as it fled through the school yard. Alexander Walder: Possibly fatal injuries. Helen Barr: Hands and arms lacerated. Harding Christ: Both legs bitten. Wendell Loomis: Both legs and left forearm bitten. Ralph Asor: Bitten on both hands. 1916-6-24New York City, New YorkTwo 6-year-old girls injured (Sarah Cohen and Mary Catino) Brindle bulldog ran into a schoolyard during recess and before the teachers could shepherd the students away, two young girls were bitten. Both bitten 1923-6-15Greenville, OhioAt least 4 children injured (Mary Agnes West and Jack West, others unknown) Bulldog ran amuck and is believed to have attacked at least four children before being killed. Two of the children were knocked down in front of a saloon and bitten. The saloon owner kicked the dog, and it then ran into a crowd of children as school was dismissed. It is believed to have bitten two more children. A man crippled it with a gun, and an attorney fired a load from a riot gun. It was shot again and required two more shots. Finally it was dispatched with an iron bar. Mary Agnes West: Bitten on the right knee and back of the left hand. Jack West: Bitten in the left arm. 1925-9-19Hammond, Indiana10-year-old boy injured (Joseph Nelson) 10-year-old boy at a school attacked by a bulldog. Witnesses claim that it was a wonder he did not lose his life. The dog did not appear to be a vicious animal and the owner claimed that boys had been teasing him. He was normally tied up but on that day was released by someone. Frightfully lacerated 1926-5-21Anaconda, Montana4 young boys injured (John Grugovich, Lester Walters, Jack Weis, Luke Lucier) Four schoolboys bitten by a dog that was running at large when school was dismissed. The first boy tried to play with the dog, when it bit him without warning in the foot, then the leg, inflicting fairly serious wounds. Three other boys helped chase the dog off and were also bitten. John Grugovich: Bitten in the foot and calf. The other 3 boys: Bitten in the hands. 1926-11-16Oakland, California10-year-old girl, 12-year-old boy injured (Myrtle Jackson, Tommy Shower) 10-year-old girl attacked in the schoolyard as children attempted to take their ball back off a loose bulldog that had caught it. A 12 year old boy shoved her aside and grabbed the dog, attempting to drag it out of the yard, and being bitten in the process. Myrtle Jackson: Lacerated, bitten 10 times. Tommy Shower: bitten 10 times. 1934-12-20Chicago, Illinois8-year-old girl, 6-year-old girl, 8-year-old boy, 8-year-old boy, 10-year-old girl injured (Corine Friedl, Mildred Kehling, Robert Behler, Howard Mason, Anne Mineham) Bull terrier bursts into a classroom and bites five students. The teacher throttled the dog, but it escaped. All bitten I wonder if people wrote into the respective papers victim-blaming the children like they do on Facebook when pit bulls attack students at school? As before, I can provide the article text or scans/images if people are interested in reading the articles themselves |
2024.03.18 20:51 Busy-Emotion3754 Reckless driving charge has real chance of putting me in jail. What do I need to know about this process.
2024.03.14 22:00 melonkoly81 Contempt case against Norfolk Commonwealth’s Attorney Ramin Fatehi dismissed after apology to judge
2024.02.28 20:37 melonkoly81 Norfolk Commonwealth’s Attorney Ramin Fatehi ordered to appear before judge for possible contempt of court charge
The order says that Fatehi “openly insulted and resisted the powers of the court” and engaged in acts “calculated to embarrass, hinder or obstruct the court in the administration of justice.” submitted by melonkoly81 to HamptonRoads [link] [comments] |
2024.02.24 18:15 greatredditusername Are there realistically GS opportunities for spouse of active duty service member in Bahrain?
2024.02.23 01:29 PanAmFlyer Captain George Alexander Bew House - Circa 1915
https://preview.redd.it/j3il8ff2c8kc1.jpg?width=397&format=pjpg&auto=webp&s=387da67c275cda32c6be9cafeebe82913961f101 submitted by PanAmFlyer to norfolk [link] [comments] 1215 Colonial Avenue, in Norfolk's Ghent neighborhood, was built in 1915 and was home to Captain George Alexander Bew, his wife Louise and their daughter Carol. Captain Bew was a Shipbuilding Engineer and a Branch Pilot. Branch Pilots were trained to captain a variety of ships and certified by the State. They stayed onsite at several places, most notably the mouth of the Chesapeake bay, and took charge of incoming vessels, piloting them through difficult waters to their final destination. Captain Bew was involved in some controversy in 1926 when he claimed his legal appointment, and the high degree of regulation for his position as a Branch Pilot, made him a state officer. Therefore, he claimed, his income was tax exempt. At the time the Federal income tax was only 13 years old, and there were many test cases in the courts. Captain Bew's case (Bew vs US) made it to the Supreme Court before a ruling against him was handed down. Captain Bew's daughter, Carol Catherine Bew, attended Vanderbilt University before marrying attorney Daniel McGugin and residing in Nashville, Tennessee. She was part of a group of Nashville women in the early 1950s who persuaded the state to purchase Nashville's historic Belle Meade Mansion. Belle Meade is dedicated to the preservation of Tennessee’s history, architecture, hospitality, and equestrian legacy. |