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Liv Pure Reviews (update 2024) Real Official Website Claims or Negative Results!

2024.04.28 17:34 Medium-Consequence22 Liv Pure Reviews (update 2024) Real Official Website Claims or Negative Results!

Research findings indicate that if you’re struggling to lose weight, compromised liver function can be at the core of the issue. To support a healthy body fat percentage and get rid of excess fat, you may need to tackle impaired liver function and accelerate the fat-burning mechanism.
Consequently, Liv Pure emerges as a fat-burning solution that targets impaired liver function, leveraging the properties of natural ingredients. The weight loss supplement serves a dual purpose: supporting liver health and weight loss.
Liv Pure supplement is a no-brainer for people who are searching for a dietary supplement that can aid in losing weight and supporting optimal liver function. But is it safe? And will it really work? If you’ve such doubts, this Liv Pure review is for you.
In this Liv Pure review, we’ve emphasized the formulation, scientific evidence, safety and suitability, and other important things you should know to make an informed choice regarding the Liv Pure formula.
With that said, let us tell you that Liv Pure stands as a natural weight reduction solution that supports your overall well-being, delivering multiple health benefits like preventing body fat accumulation, fighting fatty liver disease, preventing liver inflammation, promoting healthy liver function, and more.
Before we delve into its additional health benefits and how the natural ingredients in Liv Pure work to achieve them, let us give you an overview of what the Liv Pure formula is about.
Category:
Dietary supplement
Aim:
Healthy weight loss and optimal liver health
Liv Pure Product Form:
Pills
Suitability:
Healthy adults
Unique Feature:
A blend of two complexes: Liver fat-burning complex and Liver purification complex
Characteristics:
Health Benefits:
Price:
From $69 (Official Website)
Vegan-Friendly:
Yes
Natural Ingredients:
Liver fat-burning complex: Resveratrol, Genistein, Camellia Sinensis, Choline, and Chlorogenic Acid
Liver purification complex: Sylimarin, Betaine, Berberine, Molybdenum, and Glutathione
Pros:
Cons:
Money-Back Guarantee:
60-day money-back guarantee

Simplifying The Mode of Operation: How Does Liv Pure Work To Accelerate Weight Loss Efforts?

The natural ingredients in Liv Pure work to weave an elaborate mode of operation to effortlessly support healthy weight loss and overall well-being. The potent weight loss solution doesn’t merely curb food intake or hunger but launches a liver detoxification process that diminishes the toxin and liver fat content, allowing healthy liver function and liver cells.
By addressing poor liver health, Liv Pure pills support your weight loss journey and accelerate your liver’s ability to process excess fat. Furthermore, the Liv Pure supplement facilitates metabolism, promoting fat-burning mechanism to deplete fat storage.
This weight management and liver health supplement also supports the health of liver cells, reduces liver inflammation, combats fatty liver disease, and more by utilizing its unique complexes.

Facts About The Formulation of Liv Pure’s Unique Formula

Inhibiting weight gain with its remarkable formula, this liver health and weight loss supplement features some amazing aspects that make its formula one-of-a-kind. Take a look at what the creators have done to make this liver health supplement a game changer.
Ingredients Sourcing And Ethical Consideration
Liv Pure supplement features clinically proven super nutrients and natural ingredients that have been sourced from around the world, practicing sustainable and ethical standards. Additionally, the manufacturers have blended the clinically proven super nutrients in a scientifically precise ratio to create the potent liver purification complex and the liver fat-burning complex.
Manufacturers of The Liv Pure Supplement
Liv Pure reviews claim that the creators of the Liv Pure weight loss supplement are Dan Saunders and Dr. Nicholas Andino. However, the Liv Pure official website doesn’t disclose anything regarding the manufacturers, except the ingredient list and the scientific discovery that led to the creation of the Liv Pure weight loss supplement.
Safety And Quality Standards
The Liv Pure official website states that the weight management and liver health supplement has undergone rigorous third-party lab testing and clinical trials to ensure its potency, safety, and quality. Liv Pure pills have been deemed fit, and Liv Pure reviews reflect that people who consume Liv Pure pills don’t suffer any side effects.

Outstanding Markers of The Liv Pure Weight Loss Supplement

The revolutionary Liv Pure supplement can be an effective and potent ally in your weight loss journey, helping prevent fat accumulation and accelerating fat metabolism. There are some distinct markers of the Liv Pure weight loss formula that make it the right fit for all individuals
The encapsulated form is convenient to use, and the optimal size of Liv Pure pills makes it easier to wash down the pills to reduce fat mass. Additionally, the Liv Pure supplement is vegan-friendly and suitable for everyone (inclusive).
Another amazing feature of the Liv Pure weight loss formula that you may not see in most weight loss supplements is its ability to support your overall well-being. From cognition to improved sleep quality, the Liv Pure supplement can help you take the first step toward total wellness.
Click here to visit the official website for Liv Pure >>>

Why Liv Pure Reviews Report The Dietary Supplement Is A Broad Spectrum

Liv Pure reviews reflect that the Liv Pure weight loss supplement does more than just lose weight and prevent weight gain. Delivering multiple health benefits, this weight management and liver health supplement can be categorized as a broad spectrum.
Facilitates Healthy Weight Loss
The Liv Pure supplement targets excessive weight gain and accelerates your weight loss efforts in multiple ways. Not only does it reduce food intake, but also accelerates the fat-burning process by promoting liver health. The weight loss supplement supports fat metabolism and prevents fat accumulation to help you lose that stubborn belly fat within a few weeks.
Sustains Healthy Blood Sugar Levels
In addition to supporting liver health and liver function, the Liv Pure supplement has been designed to support healthy blood sugar levels. The natural ingredients in the formula have been clinically tested to increase insulin sensitivity and glucose uptake.
Prevents Fatty Liver Disease
Another amazing benefit that several positive Liv Pure reviews disclose is the prevention of liver diseases. The Liv Pure weight loss supplement supports the health of liver cells and prevents them from toxins or excess fat.
Electrifies Your Energy Levels
Crawling metabolism can lead to low energy levels and lethargy. However, the Liv Pure weight loss supplement has been formulated to boost your energy levels and help you live an active life. The liver health and weight management supplement aids in promoting fat burning to maximize energy production.
Supports Liver Health
The revolutionary weight loss supplement has been designed to sustain a healthy liver by detoxifying specific liver cells. Subsequently, the natural ingredients in Liv Pure work to support liver health and optimal liver function to support your overall well-being and reduce body weight.
Improves Your Cognitive Function
The Liv Pure official website discloses that this bad boy can also improve your cognitive functions and improve your thinking abilities. The dietary supplement is loaded with ingredients and nutrients that promote cellular health and nourish your brain to sharpen its cognitive abilities.
Get Liv Pure now while it’s on sale – limited time only!
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2024.04.28 07:59 ultracute007 Serolean Reviews 2024– Real Ingredients for Natural Weight Loss Support OR Scam?

Serolean Reviews 2024– Real Ingredients for Natural Weight Loss Support OR Scam?

What Is SeroLean?

SeroLean is a cutting-edge weight management formula created by Dr. Robert Posner, a board-certified physician, author, and weight loss expert to help people suffering from overweight and obesity. According to the official website, it is a breakthrough solution that’s radically different from every other supplement on the market by using a systematic program for naturally boosting serotonin levels, the primary cause of unhealthy weight gain.
Now coming to other aspects of the formula, the SeroLean weight loss formula is developed as easy-to-swallow capsules, where each supplement bottle contains 60 capsules (1 month’s supply). In addition, the supplement’s quality and potency are ensured by using only clinically backed natural ingredients and manufacturing it under a state-of-the-art FDA-registered and GMP-certified facility in the United States.
​
Serolean Reviews 2024– Real Ingredients for Natural Weight Loss Support OR Scam?

How Does SeroLean Weight Loss Formula Work?

SeroLean works by addressing the root cause of the weight gain. For decades, we believed that people struggled with weight due to a lack of willpower or lack of discipline. On the contrary, it has been proven to be due to stress eating, carb cravings, and anxiety, which are all symptoms of a biological condition called serotonin imbalance.
Serotonin is a naturally occurring chemical in our brain often referred to as the ‘happy hormone’. It’s a vital neurotransmitter that regulates your mood, appetite, sleep, digestion, and cognition. So, when the normal serotonin levels go out of balance, we will atomically struggle with cravings, stress and emotional eating, insomnia, and low energy levels.
So, under these conditions, losing weight seems to be impossible and it cracks all of your weight loss efforts. So, with the SeroLean supplement the manufacturer targets to optimize serotonin levels. The supplement also provides a host of metabolic cofactors for complete recovery and maintaining long-term results.
Confused About How To Use SeroLean? Click Here To View The Supplement Label!

Explore SeroLean Ingredients And Their Roles

The Serogenesis system utilizes a unique blend of clinically proven natural ingredients that works in synergy 24/7 with your body. Here are the SeroLean ingredients along with their health benefits.
Stinging nettle leaf
Stinging nettle is a nutritious plant popular in Western medicine where it is commonly used as an adaptogen. It’s proven to support the adrenal gland and endocrine system to produce serotonin as well as supply a small but significant dose of the actual serotonin to the body. Being rich in antioxidants and anti-inflammatories, it can be a great comfort for digestive and metabolic issues.
5-HTP
5-hydroxytryptophan is an amino acid that is naturally present in our body acting as a precursor to serotonin production. This SeroLean ingredient helps raise serotonin levels in the brain and has a positive effect on our mood, anxiety, appetite, and pain sensations.
Saffron extract
Saffron is a rare spice that is rich in antioxidants and elements that can help elevate mood and treat depression. In addition, compounds present in this spice can also reduce cravings, boost serotonin levels, and improve memory and learning ability.
L-tryptophan
This is an amino acid that helps convert into serotonin in the gut which affects our mood, cognition, and behavior.
Green tea extract
Green tea contains a type of polyphenol called catechin that is shown to support cognition, metabolism, and blood sugar levels.
Visit The Official SeroLean Website For Detailed Ingredient Information

What Are The Primary Benefits Of SeroLean?

Note this section is written as per the customer feedback on what you can realistically expect from using the formula.
Lifts mood
In as little as a week, you can expect a lift in mood and a reduction in anxiety throughout the day. So, gradually you will feel calmer and more relaxed.
Boosts energy levels
With your mood in check, you are supposed to experience a significant rise in your energy levels. The SeroLean supplement also helps you get a good night's sleep, so you wake up feeling energized.
Supports weight management
Increased energy levels and mood lead to a reduction in appetite and more control over stress eating. Also, it helps boost your metabolism 24/7 even while you sleep. Ultimately, all of these will result in weight loss.
Check The Availability Of Serolean On The Official Website

Analysing Pros And Cons Of SeroLean

Let’s recap the pros and cons of SeroLean before concluding. This is to give you better clarity on the supplement and to guide you in making an informed decision.
Pros Of SeroLean
  • All-natural formula
  • Doctor formulated
  • Science-backed ingredients
  • Non-GMO
  • Reasonable price
  • 60-day money-back guarantee
  • Free bonuses
Cons Of SeroLean

Can SeroLean Cause Side Effects?

Since its release, thousands of customers have used it and so far, there have been no reports of any side effects from using the supplement. This shouldn’t come as a surprise as SeroLean supplement is doctor-formulated, natural, and manufactured in an FDA-registered and GMP-certified facility.
However, the manufacturers say the supplement contains a limited amount of caffeine in it. So, if you suffer from caffeine sensitivity, you should consult your doctor or consider taking only one capsule of the formula.
Check The Availability Of Serolean On The Official Website

How To Use SeroLean Capsules For Better Results?

According to the official website, it is recommended to take 2 SeroLean capsules once a day each morning before a meal with a glass of water.
As for the SeroLean PM formulation which comes as a bonus, it’s advised to take 2 capsules once a day, 30 minutes before your bedtime, with or without food.

SeroLean Customer Reviews And Complaints

If you search for the supplement on the internet, you can see plenty of SeroLean customer reviews, and there are hardly any complaints or concerns. The official website has also posted an array of written and video testimonials from verified customers. Most of the customers state that they have seen a significant change in their cravings, metabolism, and sleep cycles.
Individuals who have used it consistently for longer periods have commented it has helped them lose from 50 to 120 pounds and more. Even people who have tried multiple treatments, lifestyle DIYs, and other supplements and failed have found SeroLean effective. They say it made them feel confident in their body and lead a life they dreamed of.
Click To Read Genuine Customer Reviews About SeroLean

Where To Order SeroLean? Pricing And Refund Policy

Due to its high demand, several 3rd party websites and retail platforms have been selling duplicates of SeroLean capsules. However, the manufacturers guarantee that it is only available on the official website. No matter what supplement you choose to buy, it is important to get it from authentic sites. So, make sure to purchase the formula from its official website.
By purchasing the supplement from the official SeroLean website, you become eligible to avail the latest offers. Here are the details of pricing and packages available on the official website at a glance:
  • 1 Month Supply - $59/bottle
  • 3 Month Supply - $147 ($49/bottle) + 1 Free SeroLeanPM Bottle
  • 6 Month Supply - $234 ($39/bottle) + 2 Free SeroLeanPM Bottles
To order the SeroLean weight control supplement, open the official website and select a package of your preference. Upon selecting, you will be navigated to their secured checkout page, where you will have to enter your contact and payment details. After filling in the details, click on the Pay Now button to place the order.
All SeroLean purchases are backed by a 60-day, 100% money-back guarantee. This means that if you are not fully satisfied with the product, you are entitled to a full refund.
Click Here To Order SeroLean From Its Official Website

Available SeroLean Bonuses

Here are the free SeroLean bonuses the manufacturers offer with both 3 and 6-bottle purchases:
Bonus #1: SeroLean PM Formula
The SeroLean PM formulation is designed to keep your metabolism active even while you are sleeping. It suppresses night-time cravings and binge-eating while calming your mind to improve your sleep cycle. The key ingredients used to formulate this PM formula are white kidney bean extract, ashwagandha extract, L-theanine, L-carnitine, valerian root extract, and vitamin B6.
Bonus #2: Sero For Life Plan ($97/month)
This is unlimited access to the Sero For Life member’s portal, which provides ongoing guidance on the serotonin lifestyle, daily blogs of Dr. Posner, and strategies to carry on your progress.
Bonus #3: Online Consultation ($90/hour)
This free bonus enables you to connect with trained weight loss tele-coaches for personalized guidance on your weight loss plan.
Bonus #4: Sero For Life Handbook ($30 Value)
Here in this handbook, the manufacturers offer you secrets to strategically incorporate your favorite foods without gaining weight.
Bonus #5: The Serotonin Solution To Never Dieting ($20 Value)
This is the digital copy of the best-selling book of Dr. Robert Posner that reveals how overweight can be conquered by solving serotonin imbalance.
Click To Buy SeroLean Directly From The Official Website

Final Verdict On SeroLean Reviews

After a thorough analysis of the supplement, this SeroLean review suggests that it is a genuine weight loss supplement. Its unique blend of ingredients sets it apart from other digestion support formulas and fat burner supplements available in the market. SeroLean fat burner boosts our serotonin levels and helps us gain control over weight naturally.
Moreover, the customers loved the formula and did not report any side effects. The SeroLean weight management supplement also appears to be safe as it's manufactured in a highly reputed GMP-certified and FDA-reputed facility using only natural ingredients.
Another noteworthy factor is that the supplement is backed by an iron-clad 60-day money-back guarantee. So, if you are not satisfied with the results, it gives you total freedom to ask for your money back. Considering all the above-mentioned facts, I would like to say SeroLean pills are worth a try.
Ready To Try SeroLean? Click To Make A Purchase From Its Official Website

Frequently Asked Questions About SeroLean

How long will my order take to arrive?
On average, it takes 5 to 7 days to receive the order. But if you want to have it in 3 to 5 days you can simply pay a small fee while placing the order.
How long do I use SeroLean pills for?
Given each individual’s goal and biology is different, rights might vary from one person to another. Some might reach their ideal weight in 30 days while it might take longer for others. Having said that, you must understand that weight has to be managed to avoid regaining it back. So, it is better to stick to a longer plan, preferably 3 or 6 months. This will help you reach your goals and at the same time manage the weight for a longer period.
Does SeroLean capsules offer free shipping?
While the SeroLean multipacks (3-bottle and 6-bottle supplies) are free of shipping charges in the United States, the single-bottle pack comes with a small shipping fee of $9.95.
Who should not consume SeroLean pills?
It is recommended by manufacturers that individuals who are pregnant, nursing, or under the age of 18 are supposed to consume a SeroLean fat burner. Also, if you are someone who is taking medications, especially antidepressants, or have a medical condition, you must consult your physician before taking SeroLean capsules.
How do I return my order for a refund?
To get a refund, first, you should request the refund within 60 days of placing the order by contacting the customer service team at support@serolean.com or 888-789-5699. Next, as per the advice of the customer service team, return the empty bottles. Once the package is received, your refund will be processed in a few days.
Click To Order SeroLean With A 60-day Money-back Guarantee From Its Official Website
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2024.04.28 07:49 ultracute007 ProstaBiome Reviews 2024 : Does It Enhance Prostate And Urinary Health Naturally?

ProstaBiome Reviews 2024 : Does It Enhance Prostate And Urinary Health Naturally?

What Is ProstaBiome?

ProstaBiome is an edible supplement that is designed to support prostate health. The dietary capsule contains a blend of natural ingredients that are selected from genuine sources. It helps to improve prostate health in males. The potent ingredients in the formula contain natural nutrients that help to improve urinary functions.
This supplement balances the gut bacteria and eliminates prostate parasites from the body. Men of all ages can use this formula and with various medical conditions. All the ProstaBiome ingredients have been proven safe in several clinical trials and are frequently tested for purity.
This male health formula does not contain any harmful ingredients. It is developed in an FDA-approved facility adhering to sterile, strict, and precise standards.
​
ProstaBiome Reviews 2024 : Does It Enhance Prostate And Urinary Health Naturally?

How Does ProstaBiome Formula Work?

ProstaBiome is a natural formula that comes with a blend of all-natural ingredients. The manufacturer has blended this supplement to support prostate health in men.
Recent scientific studies found that the crucial factor that contributes to discomfort is the presence of specific microorganisms that affect the functions of the prostate. These are bugs that chew your gut lining and make their way to the prostate. This can be resolved by supplementing with nutrients and natural ingredients.
ProstaBiome male health support supplement is crafted with natural ingredients that balance gut bacteria and eliminate prostate parasites. This dietary capsule helps flush out parasites that are harmful to the body. The formula tackles the common cause of an unbalanced prostate and gut health. It supports urinary health with the help of natural ingredients.
Interested To Know How ProstaBiome Supplement Was Made: Click Here!

What Goes Into The Formulation Of ProstaBiome?

ProstaBiome capsules are crafted with a blend of scientifically proven ingredients. The manufacturer has used each ingredient after detailed scientific research.
In this section, let’s check if the ingredients are apt and do they help to improve prostate health.
Saw Palmetto
Saw Palmetto is a plant extract that helps to improve prostate health. It also helps balance the hormonal changes in men. It reduces the symptoms associated with an enlarged prostate.
Cinnamon Bark powder
Cinnamon Bark powder comes with multiple health benefits. It is found that this ProstaBiome ingredient reduces prostate health issues. The bioactive compounds of this ingredient help to support overall health.
Grape Seeds
Grape Seeds contain resveratrol that neutralizes free radicals that cause inflammation and other issues. It manages the inflammation in the prostate and other body parts.
Kelp Extract
Kelp Extract is packed with nutritional quality that helps the body in many ways. The crucial nutrients in this ingredient help reduce prostate issues. It helps to eliminate bacteria and harmful microorganisms from the body.
Vinitrox
This ProstaBiome ingredient comes with nutritional properties that help reduce the risk of prostate cancer. It improves urinary functions, reduces inflammation, and supports overall health.
Beta-Sitosterol
Beta Sitosterol is found in plants, seeds, nuts, and fruits. It is shown to support prostate health and reduce inflammation. It reduces urinary tract infections and improves urine flow.
Other ingredients are provided on the supplement label. If you are interested to know more about the proprietary blend, you can visit the ProstaBiome official website.
Learn More About ProstaBiome Ingredients From Its Official Website: Click Here

Health Benefits Of Taking ProstaBiome Supplement

You can use this supplement for different purposes, it not only supports a healthy prostate but also improves overall health. Here are some of the key benefits of incorporating ProstaBiome pill into a healthy lifestyle.
Supports urinary health
The ProstaBiome ingredients support a healthy urinary system. This formula eliminates and flushes out infectious parasites and bacteria. It prevents UTIs and complicated infections.
Reduce enlarged prostate
An enlarged prostate is responsible for a weak urine stream and other urinary problems. ProstaBiome male health formula helps reduce enlarged prostate with the help of natural ingredients.
Improves quality of life
Improvement in prostate health may reflect the quality of life. When the prostate issues are resolved, you can see positive changes in your energy levels, physical activities, and more.
Support the immune system
The supplement provides ingredients that help the immune system. You can experience better stamina and strength after consuming the ProstaBiome prostate formula.
Check The Availability Of ProstaBiome On Its Official Website

What Are The Pros And Cons Of ProstaBiome?

In this section of the ProstaBiome review, we will be discussing the positive and negative sides of this supplement. This evaluation will help to understand how effective this formula works in your body and show results.
Pros of ProstaBiome
  • There are no severe side effects
  • Offers multiple health benefits
  • It is vegan-friendly, gluten-free, and non-GMO supplement
  • Formulated in the United States of America
  • Made in an FDA-registered facility that adheres to strict FDA regulations
  • The manufacturing process is monitored by experts
  • It can be easily purchased from the official ProstaBiome website
Cons of ProstaBiome
  • May get out of stock quickly
  • Results may vary for each person

What Is The Right Way To Use ProstaBiome?

The manufacturer has included an appropriate amount of ingredients in the supplement. You should take one capsule of this prostate health formula for best results. Morning is the right time to consume the capsules.
You can take this capsule alone on an empty stomach or with coffee or any food. You are not allowed to exceed the ProstaBiome dosage provided by the manufacturer.

Any Side Effects Of ProstaBiome Reported?

ProstaBiome male health pills are formulated with healthy, all-natural ingredients. The manufacturer has designed this formula for all men of all ages and with various medical conditions. The manufacturer has used only natural and pure ingredients in the supplement.
There are no ingredients included that cause side effects or health issues. People who have tried this formula have not reported any health issues up to this date. The only thing to consider is following the dosage instructions of the manufacturer. You may experience mild headache, dizziness, or stomach upset if you exceed the recommended dosage.
You can simply avoid such situations by sticking to the dosage instructions. However, manufacturing standards play a vital role in the safety of dietary supplements. In the case of the ProstaBiome blood flow supplement, is made in an FDA-approved facility in the USA.
Click To Access The Official ProstaBiome Website To Check Its Availability

How Long Does It Take ProstaBiome To Show Results?

ProstaBiome formula takes at least 3 to 6 months for noticeable results. The manufacturer suggested strictly following the dosage instructions to witness the results. However, results may differ from individual to individual due to the influence of distinct factors. People with other health issues may not experience results within the promised time.
Also, the results may depend on how effectively it is consumed. It is important to follow a healthy lifestyle along with the supplement. ProstaBiome natural prostate health formula can be used for the long term as it does not cause any side effects.

ProstaBiome Real User Reviews And Complaints

This dietary supplement has been used by thousands of men who seek prostate health support. In all the ProstaBiome customer reviews all the users seem satisfied with the results. The only complaints that have been received are related to the availability. Due to high demand, the supplement may get out of stock very quickly.
Apart from this, there are no complaints related to the working of the formula. The majority of the users say that the ProstaBiome herbal supplement helped them recover from prostate issues naturally.
Click Here To Read Real ProstaBiome Customer Reviews

Where To Order ProstaBiome? Pricing And Refund Policy

The supplement can only be purchased from theofficial ProstaBiome website. No other seller in e-commerce or retail stores has been authorized to sell the formula. You will get different purchase options that help you to choose according to your budget and affordability.
Let’s see the ProstaBiome price details:
  • Get one bottle pack at $59 for a 30-day supply
  • Get a three-bottle pack at $49 each for a 90-day supply
  • Get a six-bottle pack at $39 each for a 180-day supply
You can save money while purchasing multiple bottle packs. Moreover, it is backed by a 100% money-back guarantee of 60 days. This is the plus point of this formula. If you don’t experience the promised results, the manufacturer will refund your money if it is only purchased from the official website.
Click Here To Order ProstaBiome From Its Official Website

Bonuses Included With ProstaBiome

Two free books are available in three and six-bottle packs. Here are the details of ProstaBiome bonuses:
Free Bonus eBook #1: The Strength of T
As a complementary resource to the ProstaBiome prostate health supplement, the free bonus eBook "The Strength of T" provides valuable insights and strategies for men to naturally enhance their testosterone levels.
Free Bonus eBook #2: The Power of Performance
This bonus eBook "The Power of Performance" equips men with proven techniques to elevate their overall well-being and productivity.
Click Here To Buy ProstaBiome From Its Official Website

Concluding Thoughts On ProstaBiome Reviews

After a detailed analysis of this ProstaBiome review, it can be concluded that this is a pure and natural formula for prostate health. The manufacturer has included all-natural ingredients in the supplement to provide maximum results.
The blend of probiotic ingredients helps remove bacteria and parasites responsible for prostate issues. The gut bacteria that attacks the gut lining may damage the digestive system and prostate. The active ingredients in the formula kill all the bacteria and filter the body.
ProstaBiome energy-boosting pill supports the urinary system and helps maintain healthy urine flow. All men of various ages and health conditions can use this dietary supplement. It is a safe and pure formula that is processed in an FDA-approved and GMP-certified lab facility.
Thousands of people who have used this capsule do not mention any side effects. While considering all the factors of ProstaBiome, we can consider this prostate health supplement as a safe and pure formula.
Click Here To Place Your Order From The ProstaBiome Official Website

FAQs About ProstaBiome Supplement

Can I use this supplement with other medicines?
Yes. The manufacturer says that the ProstaBiome supplement can be used by all men with any health condition. Also, the ingredients used do not have any reactive properties so they can be used safely.
Does it contain chemicals?
ProstaBiome prostate health capsules do not contain artificial chemicals that damage the body. It is 100% natural and free from man-made ingredients.
Can I take the ProstaBiome tablet for a long time?
You can use this supplement for a long time and it does not cause any harm to the body. Instead, it provides additional support such as improving sleep, maintaining a good mood, and more.
What if I am not satisfied with the results?
If you are not satisfied with the ProstaBiome results, you can ask for your money back. This option is valid for the first 60 days from the date of purchase.
How long does delivery take?
If you reside in the USA, it may take 5 to 7 business days to reach your doorstep. The ProstaBiome manufacturer starts the processing within 2 days once the order is confirmed.
Click To Order ProstaBiome With A 60-day Money-back Guarantee From Its Official Website
Note - This article is written by Brand Desk.
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2024.04.28 06:22 ReportsStack Buccal Drug Delivery Systems Market Size, Industry Trends & Growth Analysis from 2024 to 2030

The global buccal drug delivery systems market was valued at approximately USD 3 billion in 2020 and is projected to experience a notable compound annual growth rate (CAGR) exceeding 9% during the forecast period to 2027. A key driver of this growth is the rising population of geriatric patients, alongside an increasing demand for convenient drug delivery methods. Moreover, the growing preference for buccal drug delivery systems, coupled with ongoing research and development efforts in the field, are anticipated to further propel market expansion throughout the forecast period.
To know more about this study, request a free sample report @ https://www.researchcorridor.com/request-sample/?id=54366
Market Trends:
· Growing Preference for Non-Invasive Drug Delivery: There is a rising preference for non-invasive drug delivery methods among patients and healthcare providers. Buccal drug delivery systems offer a non-invasive route of administration, avoiding the need for injections or swallowing pills. This trend is driving the adoption of buccal drug delivery systems, particularly for patients who have difficulty swallowing or are averse to needles.
· Expansion of Drug Formulation and Delivery Technologies: Advancements in drug formulation and delivery technologies are expanding the capabilities of buccal drug delivery systems. Novel formulations such as mucoadhesive films, gels, and tablets are being developed to improve drug absorption and bioavailability through the buccal mucosa. Additionally, innovative delivery devices and technologies, such as patches and sprays, are enhancing the ease of administration and patient compliance.
· Increasing Focus on Patient-Centric Healthcare: There is a growing emphasis on patient-centric healthcare, with healthcare providers prioritizing treatments that offer convenience, comfort, and improved quality of life for patients. Buccal drug delivery systems align with this trend by providing a convenient and patient-friendly alternative to traditional drug delivery methods. This trend is driving the development of patient-friendly buccal dosage forms and user-friendly delivery devices.
· Expanding Applications in Chronic Disease Management: Buccal drug delivery systems are finding expanding applications in the management of chronic diseases such as diabetes, cardiovascular diseases, and neurodegenerative disorders. These systems offer controlled and sustained drug release, allowing for better disease management and improved patient outcomes. As the prevalence of chronic diseases continues to rise globally, the demand for effective and patient-friendly drug delivery systems like buccal delivery is expected to increase.
Market Opportunities:
The buccal drug delivery systems market offers significant opportunities for growth and innovation. Firstly, there is a growing demand for non-invasive drug delivery methods among patients and healthcare providers, presenting an opportunity for the expansion of buccal drug delivery systems. Additionally, advancements in drug formulation and delivery technologies enable the development of novel buccal dosage forms with improved drug absorption and bioavailability, further driving market growth. Moreover, the increasing focus on patient-centric healthcare creates opportunities for the development of patient-friendly buccal drug delivery systems that offer convenience, comfort, and improved treatment adherence. Expanding applications in chronic disease management, particularly for conditions requiring controlled and sustained drug release, present another avenue for market expansion.
According to the recent report published by RC Market Analytics, the Global Buccal Drug Delivery Systems Market is expected to provide sustainable growth opportunities during the forecast period from 2023 to 2030. This latest industry research study analyzes the buccal drug delivery systems market by various product segments, applications, regions and countries while assessing regional performances of numerous leading market participants. The report offers a holistic view of the buccal drug delivery systems industry encompassing numerous stakeholders including raw material suppliers, providers, distributors, consumers and government agencies, among others. Furthermore, the report includes detailed quantitative and qualitative analysis of the global market considering market history, product development, regional dynamics, competitive landscape, and key success factors (KSFs) in the industry.
Browse the Full Report Discretion @ https://www.researchcorridor.com/buccal-drug-delivery-systems-market/
Geographically, the buccal drug delivery systems market report comprises dedicated sections centering on the regional market revenue and trends. The buccal drug delivery systems market has been segmented on the basis of geographic regions into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. Buccal drug delivery systems market estimates have also been provided for the historical years 2020 & 2021 along with forecast for the period from 2023 - 2030.The report includes a deep-dive analysis of key countries including the U.S., Canada, the U.K., Germany, France, Italy, China, Japan, India, Australia, Mexico, Brazil and South Africa, among others. Thereby, the report identifies unique growth opportunities across the world based on trends occurring in various developed and developing economies.
The Buccal Drug Delivery Systems Market Segmentation:
By Type:
By Application:
By End-User:
By Region:
Key players in the global buccal drug delivery systems market include Pfizer Inc., Teva Pharmaceutical Industries Ltd., Indivior Pharmaceuticals, GlaxoSmithKline plc., and Catalent, Inc. These companies are strategically navigating the market landscape through various approaches such as expansion, new investments, the introduction of innovative services, and collaboration. In their pursuit of a competitive edge, these entities are venturing into new geographical regions via both expansion and acquisition, aiming to harness joint synergies and bolster their market positions.
To know more about this study, request a free sample report @ https://www.researchcorridor.com/request-sample/?id=54366
Key Questions Answered by Buccal Drug Delivery Systems Market Report:
About Us: RC Market Analytics is a global market research firm. Our insightful analysis is focused on developed and emerging markets. We identify trends and forecast markets with a view to aid businesses identify market opportunities to optimize strategies. Our expert’s team of analysts’ provides enterprises with strategic insights. RC Market Analytics works to help enterprises grow through strategic insights and actionable solutions. Feel free to contact us for any report customization at sales@researchcorridor.com.
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Company Name: RC Market Analytics Pvt. Ltd. Contact Person: Vijendra Singh Email: sales@researchcorridor.com Visit us: https://www.researchcorridor.com/
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2024.04.28 05:35 Lazy-Butterfly-4587 Insurance changes what it pays for.

So long story short been killing it with my shot and went to fill it and got told my insurance has took it off it’s formulation or something I’m the office manager at my work and I’m going to try and appeal it but I know how this works. My Dr sent in for a PA it just got denied has anyone heard of pill form glp1 medicines if so do they work?
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2024.04.28 03:08 haniyato Unveiling the Top Male Enhancement Pills of 2024: A Comprehensive Review

In the realm of men's health and wellness, male enhancement pills continue to gain prominence as a popular solution for addressing various aspects of sexual performance. With advancements in science and technology, the market is flooded with an array of options promising to enhance libido, improve stamina, and boost overall satisfaction. In this article, we'll delve into the best male enhancement pills of 2024, providing a detailed review of their ingredients, benefits, and efficacy to help you make an informed choice.
VigRX Plus uses scientifically substantiated ingredients to help boost multiple elements of a man's sexual wellness
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  1. VigRX Plus: VigRX Plus stands out as a leading male enhancement pill renowned for its clinically proven formula and impressive results. Combining traditional herbal extracts with modern scientific research, VigRX Plus targets multiple facets of sexual health, including libido, erection quality, and endurance. Ingredients like horny goat weed, ginkgo biloba, and saw palmetto work synergistically to enhance blood flow, testosterone levels, and sexual performance. With a track record of positive reviews and customer satisfaction, VigRX Plus remains a top choice for men seeking effective and reliable enhancement.
  2. Male Extra: Male Extra offers a potent blend of natural ingredients designed to optimize sexual function and vitality. With key components like pomegranate, L-arginine, and MSM (Methyl Sulfonyl Methane), Male Extra focuses on improving blood circulation, enhancing nitric oxide production, and supporting overall sexual health. Regular consumption of Male Extra may lead to stronger erections, increased stamina, and heightened pleasure, making it a popular choice among men looking for comprehensive male enhancement solutions.
  3. Viasil: Harnessing the power of botanical extracts and nutrients, Viasil offers a holistic approach to male enhancement. Its proprietary formula includes ingredients like epimedium brevicornum, zinc, and citrus sinensis, known for their vasodilatory and energy-boosting effects. Viasil works by improving blood flow to the penis, increasing oxygen delivery to muscle cells, and enhancing ATP production, resulting in improved stamina, performance, and overall sexual satisfaction. With its natural ingredients and clinically proven efficacy, Viasil stands as a reliable option for men seeking safe and effective enhancement.
  4. ExtenZe: ExtenZe is a popular male enhancement pill formulated with a unique blend of herbs, amino acids, and nutrients. Ingredients like Korean ginseng, tribulus terrestris, and horny goat weed are known for their aphrodisiac properties and ability to support sexual health. Regular use of ExtenZe may lead to improved libido, stronger erections, and enhanced pleasure, making it a preferred choice for men looking for a quick and convenient enhancement solution.
  5. Prosolution Plus: Prosolution Plus offers a specialized formula designed to address premature ejaculation and improve overall sexual function. Combining ancient Ayurvedic herbs with modern science, Prosolution Plus contains ingredients like tribulus terrestris, mucuna pruriens, and ashwagandha, known for their libido-boosting and stamina-enhancing effects. By promoting neurotransmitter balance and reducing stress levels, Prosolution Plus helps men prolong their sexual encounters and achieve greater satisfaction. With its clinically proven efficacy and positive user testimonials, Prosolution Plus remains a trusted option for men seeking enhanced sexual performance and control.
VigRX Plus uses scientifically substantiated ingredients to help boost multiple elements of a man's sexual wellness
Conclusion: When it comes to male enhancement, choosing the right pill can make all the difference in achieving desired results. The best male enhancement pills of 2024 offer a blend of natural ingredients, scientific research, and proven efficacy to address various aspects of sexual health and performance. Whether you opt for VigRX Plus, Male Extra, Viasil, ExtenZe, or Prosolution Plus, it's essential to prioritize safety, quality, and reliability. By selecting a reputable brand with a track record of positive reviews and customer satisfaction, you can embark on a journey towards improved sexual confidence, satisfaction, and overall well-being.
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2024.04.28 01:59 haniyato Unlocking Intimacy: The Top 10 Sexual Enhancement Pills for Men in 2024

In the realm of men's health and wellness, sexual enhancement pills have gained significant traction. With advances in science and technology, today's market offers a plethora of options designed to address various aspects of male sexual performance. Whether it's boosting libido, improving endurance, or enhancing satisfaction, these pills cater to a wide spectrum of needs. In this article, we'll delve into the top 10 sexual enhancement pills for men to consider in 2024, providing insights into their ingredients, benefits, and effectiveness.
VigRX Plus: A Unique Blend ... Crafted by Leading Edge Health, VigRX is a renowned male enhancement supplement that aims to boost sexual performance
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  1. Viagra Connect: One of the most renowned names in the field of sexual enhancement, Viagra Connect continues to be a go-to option for many men. Its active ingredient, sildenafil, works by increasing blood flow to the penis, facilitating erections. With its proven track record and widespread availability, Viagra Connect remains a staple choice for addressing erectile dysfunction.
  2. Cialis: Similar to Viagra, Cialis contains tadalafil as its active ingredient. It offers a longer duration of action, earning it the nickname "the weekend pill." Cialis is preferred by men seeking spontaneity in their sexual encounters, as it can remain effective for up to 36 hours. Its versatility and reliability make it a top contender in the market.
  3. Levitra: Levitra, another phosphodiesterase type 5 (PDE5) inhibitor, boasts efficacy in treating erectile dysfunction. Vardenafil, its active component, aids in achieving and maintaining erections by relaxing muscles in the penis and increasing blood flow. With its rapid onset of action and minimal side effects, Levitra appeals to many men seeking quick results.
  4. Viasil: Harnessing the power of natural ingredients, Viasil stands out as a potent sexual enhancement pill. It combines elements like epimedium brevicornum, zinc, and citrus sinensis to improve blood circulation, boost energy levels, and enhance overall sexual performance. Viasil offers a holistic approach to addressing erectile dysfunction, catering to those inclined towards natural solutions.
  5. Male Extra: Formulated with a blend of natural ingredients such as pomegranate, L-arginine, and MSM (Methyl Sulfonyl Methane), Male Extra focuses on improving blood flow to the penis and increasing nitric oxide levels. This results in enhanced erections, heightened libido, and improved stamina, making it a popular choice among men looking for comprehensive male enhancement.
  6. VigRX Plus: With a reputation for delivering noticeable results, VigRX Plus combines traditional herbal extracts with modern scientific advancements. Its formula includes ingredients like horny goat weed, ginkgo biloba, and saw palmetto, targeting various aspects of sexual health, including libido, erection quality, and endurance. VigRX Plus appeals to men seeking a natural approach to sexual enhancement with clinically proven results.
  7. ExtenZe: ExtenZe offers a unique blend of herbs, nutrients, and aphrodisiacs to enhance sexual performance and satisfaction. Its formula includes ingredients like Korean ginseng, tribulus terrestris, and horny goat weed, known for their libido-boosting properties. Regular consumption of ExtenZe may lead to improved erections, increased pleasure, and heightened confidence in the bedroom.
  8. Prosolution Plus: Designed to address premature ejaculation and improve overall sexual function, Prosolution Plus combines ancient Ayurvedic ingredients with modern science. Its formulation includes herbs like tribulus terrestris, mucuna pruriens, and ashwagandha, known for their aphrodisiac and stamina-enhancing effects. Prosolution Plus is ideal for men looking to prolong their sexual encounters and enhance their satisfaction.
  9. Max Performer: Max Performer stands out for its focus on optimizing testosterone levels, libido, and performance. With ingredients like maca root, horny goat weed, and Korean red ginseng, it aims to increase sexual desire, energy, and endurance. Max Performer's comprehensive approach to male enhancement makes it a preferred choice for men seeking long-term improvements in their sexual health.
  10. TestoPrime: Targeting testosterone production and hormonal balance, TestoPrime offers a holistic solution to male sexual enhancement. Its formula includes natural ingredients like D-Aspartic acid, fenugreek extract, and vitamin D, which work synergistically to support testosterone synthesis and vitality. TestoPrime is ideal for men looking to rejuvenate their libido, energy levels, and overall sexual performance.
VigRX Plus: A Unique Blend ... Crafted by Leading Edge Health, VigRX is a renowned male enhancement supplement that aims to boost sexual performance
Conclusion: In the landscape of sexual enhancement, men now have an array of options to choose from, catering to their individual needs and preferences. Whether it's addressing erectile dysfunction, boosting libido, or improving endurance, the top 10 sexual enhancement pills for men in 2024 offer diverse solutions backed by science and innovation. However, it's essential to consult with a healthcare professional before starting any new supplement regimen to ensure safety and efficacy. By making informed choices, men can unlock a fulfilling and satisfying intimate life.
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2024.04.26 18:20 NorthCharacter9165 Liv Pure Reviews (URGENT Official Website Update 2024) Fake Customer Risks Exposed!

In recent years, managing body weight has emerged as a significant concern for many. The journey towards a healthier lifestyle is often marred with misinformation and fleeting trends, making the path to effective weight management a challenging one. Amidst this backdrop, the conversation around weight management is incomplete without addressing the role of dietary supplements in facilitating a healthier, more balanced approach to weight loss.
As we delve deeper into the realm of dietary supplements, the importance of choosing the right aid becomes paramount. Among the myriad of options available, one particular supplement has begun to stand out for its innovative approach to weight management. This supplement, which we will explore in detail, promises to offer more than just a temporary fix; it aims to be a companion in the journey towards achieving and maintaining optimal health.
In the following sections, we will undertake a comprehensive exploration of this supplement, examining its composition, the science behind its formulation, and the experiences of those who have incorporated it into their wellness routines.

Basic Info- Liv Pure

Product Category: Weight Loss Supplement
Ingredients:
Liver Purification Complex:
Liver Fat-Burning Complex:
Benefits:
Pricing Options:

Understanding Liv Pure: A Revolutionary Approach to Weight Loss

In an era where health consciousness is at its peak, Liv Pure emerges as a standout solution, catering to those in pursuit of a natural and effective path to weight loss. Unlike the traditional diet pills that rely on artificial means to stimulate weight loss, Liv Pure takes a holistic approach, ensuring the body’s optimal functioning through natural healing processes. This herbal formula is ingeniously crafted with two proprietary blends that serve dual purposes: enhancing metabolic efficiency and supporting the body’s intrinsic detoxification pathways.
The first of these blends focuses on purifying the body, particularly the liver, which is central to metabolic health. By improving liver function, Liv Pure addresses one of the root causes of weight gain and difficulty in losing weight. A healthy liver enhances the body’s ability to cleanse itself of toxins, which can otherwise hinder metabolic processes and lead to fat accumulation.
The second blend is designed to turbocharge the metabolism, assisting in the more efficient burning of calories. This is achieved not through the artificial stimulation of thermogenesis but by naturally enhancing the body’s calorie-burning capabilities. This method ensures that weight loss achieved with Liv Pure is sustainable and healthful, rather than being a mere result of forced and unnatural shedding of weight.
The creation of Liv Pure is the result of extensive research into the underlying causes of stubborn belly fat and weight gain. The team behind Liv Pure has meticulously selected ingredients known not only for their weight loss properties but also for their ability to support overall health. Each ingredient has undergone scientific scrutiny to validate its efficacy, ensuring that Liv Pure delivers on its promises.
What sets Liv Pure apart is its convenience and ease of use. Encapsulated in easy-to-swallow capsules, each bottle contains a month’s supply, designed to seamlessly integrate into daily routines without necessitating drastic changes in lifestyle, diet, or exercise regimes. The simplicity of taking a daily dose of Liv Pure makes it a practical choice for those looking to support their weight loss journey without additional stress or complexity.
Liv Pure stands as a testament to the power of natural supplementation in achieving weight loss. By focusing on enhancing liver function and boosting metabolism through natural means, Liv Pure offers a gentle yet effective path to weight management. This approach not only ensures immediate benefits in terms of weight reduction but also contributes to long-term health and well-being.

Unveiling the Mechanism: How Liv Pure Revolutionizes Weight Loss

In the realm of weight management, understanding the science behind a supplement is crucial in discerning its potential impact on one’s health journey. Liv Pure distinguishes itself from the plethora of weight loss aids through its innovative approach focused on enhancing liver functionality and overall metabolic health. This section delves into the operational dynamics of Liv Pure, providing insights into why this supplement might be the game-changer in the pursuit of a healthier lifestyle.
The liver, our body’s metabolic powerhouse, plays a pivotal role in processing everything we ingest. It’s responsible for metabolizing nutrients for energy and expelling toxins, thereby maintaining our body’s equilibrium. However, an overburdened liver, struggling under the weight of toxins and inflammation, can lead to a diminished capacity for fat metabolism. This is where Liv Pure steps in, with a mission to fortify liver health and, by extension, optimize the body’s natural weight loss mechanisms.
Crafted with a blend of 100% organic ingredients, Liv Pure targets the root causes of metabolic slowdown—primarily inflammation and toxin accumulation. By fostering a healthier liver, the supplement ensures that the liver efficiently processes food, segregates nutrients from waste, and prevents unnecessary fat storage. This approach is a testament to the thoughtfulness and research invested in Liv Pure’s formulation, aiming to rebalance the body’s internal processes for sustainable weight loss.
Liv Pure reviews often highlight its distinctive strategy of not just focusing on immediate weight loss but on initiating a deeper metabolic transformation. This commitment to improving liver health sets Liv Pure apart in a market flooded with quick fixes and superficial solutions. Users of Liv Pure have reported noticing a significant difference in how their bodies manage weight, attributing it to the enhanced liver functionality and metabolic efficiency promoted by the supplement.
Click here to visit the official website for Liv Pure >>>

The Core of Vitality: Unpacking Liv Pure’s Ingredients

At the heart of Liv Pure’s revolutionary approach to weight loss and improved well-being is its meticulously curated blend of natural ingredients. Each component has been selected for its unique ability to support liver health, facilitate detoxification, and promote metabolic efficiency.
Liver Purification Complex: The Foundation of Wellness
Betaine: A naturally occurring compound in foods like spinach and beets, betaine stands out for its liver-supportive properties. It aids in the removal of fats from the liver, thus preventing fat accumulation and supporting liver function. Beyond liver health, betaine is linked to improved heart and digestive health, showcasing its multifaceted benefits.
Berberine: This compound is known for its remarkable ability to balance cholesterol levels, assisting in the reduction of bad cholesterol and the promotion of good cholesterol. Its contribution to weight management is significant, with studies suggesting its effectiveness in reducing waist circumference. Berberine’s anti-inflammatory properties further support liver healing, underscoring its critical role in metabolic health.
Glutathione: Hailed as one of the body’s most potent antioxidants, glutathione plays a crucial role in detoxifying the liver and supporting the regeneration of damaged cells. Its ability to clear toxins enhances the liver’s fat metabolism capabilities, integral for weight management and overall health.
Silymarin: Derived from milk thistle, silymarin is celebrated for its liver-protective qualities. It not only has anti-inflammatory effects but also aids in liver regeneration and inhibits the development of chronic liver disease. Its benefits extend to improving insulin sensitivity, lowering cholesterol, and supporting skin, bone, cognitive, and immune health.
Molybdenum: This essential mineral, found in beans, grains, and lentils, activates enzymes critical for detoxification and metabolic processes. It underscores the intricate connection between essential nutrients and the body’s natural detoxification pathways.

Liver Fat-Burning Complex: Igniting Metabolic Fire

Camellia Sinensis: Best known as the plant used in various teas, Camellia Sinensis is rich in polyphenols that help eliminate free radicals. It boosts metabolism and fat oxidation, leading to a reduction in body fat percentage and an improvement in liver function, highlighting the role of natural antioxidants in weight management.
Choline: Essential for fat metabolism and liver regulation, choline supports liver function, detoxifies the body, and has anti-inflammatory effects. Its comprehensive benefits for liver health underscore its importance in the body’s metabolic processes.
Chlorogenic Acid: Found in fruits and vegetables, chlorogenic acid improves liver function by reducing inflammation and preventing fat accumulation. Its protective effects against liver damage demonstrate the power of natural compounds in maintaining liver health.
Genistein: This compound plays a role in hormonal regulation, impacting fat metabolism and weight loss. Its antioxidant and anti-inflammatory properties aid in liver regeneration and detoxification, showcasing the interconnectedness of hormonal balance, antioxidant support, and metabolic health.
Resveratrol: An antioxidant found in wine and grapes, resveratrol is known for its ability to reduce cholesterol and blood sugar levels, regulate blood pressure, and support gut health. Its anti-inflammatory properties contribute to a holistic approach to managing weight and enhancing liver function.
The ingenuity of Liv Pure lies in how these ingredients are combined to target liver health as a cornerstone of metabolic wellness and weight management. By supporting liver function, reducing inflammation, and enhancing detoxification, Liv Pure addresses the root causes of weight gain and metabolic slowdown.
Order Liv Pure Right Here At The Best Prices!!
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2024.04.24 21:15 flufferpeanut Pilling a cat when you've tried everything

Hi there!
I come to you in desperation to help give my cat Mowgli his daily medication.
He's on plavix, which cannot be crushed up and mixed with food or given with a syringe – it's very bitter and causes cats to foam at the mouth. There's a liquid formulation but all the reviews on Chewy say the compounding doesn't hide the awful taste. Unfortunately it doesn't appear to have a transdermal formula.
I have plain gel caps (size 3) and chicken flavored ones (size 4) to hide the pill in. I have a pill popper and a tub of unsalted butter that's just for him.
The first few days, I was able to give him his pill by kneeling on the floor and sitting him between my knees, loading the pill into the popper, getting some butter on the end, and doing the usual "tilt his head back, pry open his mouth from the sides, and gently hold it shut and blow on his nose" method. I gave him a pile of bonito flakes afterwards and all was well.
After the first few days though, he started fighting me. Thrashing his head when I tried to tilt his head back to open his mouth and reaching his paw out to scratch me. I couldn't get the pill back far enough and he wouldn't swallow it. I had to put the pill in a new gel cap because it started to dissolve. Once I got it in his mouth, I rubbed some butter on his nose to encourage him to lick it and swallow. Then bonito flakes and lots of praise.
Yesterday it was worse. I think he bit his tongue or his lip trying to clamp his mouth shut instead of letting me give him the pill, which of course upset us both and made it harder to continue trying. After 4 or 5 attempts (and 2 new gel caps), I eventually got it in and he swallowed it.
Today was awful. I tried burrito'ing him to prevent scratching but he was so upset. I had to re-cap the pill 4 times because every time I got it in his mouth, he wouldn't swallow. I got a syringe of plain water to trickle in after I got the pill in, but it didn't work. He still spit out the pill and half-dissolved gel cap every time. Once the cap dissolved enough that he started tasting the plavix, he was furious; hissing and scratching and not letting me near him.
I do my best to stay calm, but it's so frustrating to feel like I'm upsetting or hurting my sweet boy and I desperately want him to feel better and live a long, happy life. I've tried to give him lots of calm praise before and after, but today I just cried.
I live alone and have to be able to do this myself, and I have to do it every day. I've watched every YouTube video and read every thread on Reddit and Quora. I feel like I'm doing something wrong because everyone makes it sound so easy. He's not even a generally spicy cat; he just really doesn't want to take his medication. Continuing to fight him and make him fearful of me or medication isn't a good path to go down, but I don't know what to do.
Thank you for your help ❤️
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2024.04.24 20:07 ImaginationWestern20 Day 14 of Sublingual Immunotherapy (SLIT), please tell me it gets better!

I’m allergic to grasses plus basically everything except animals. My ENT formulated the drops to my specific allergens. This is my second go around with the drops. The first time I tried I was newly pregnant (now I know you’re not supposed to start while pregnant), and my frenulum would swell to the size of a grape for an hour or two. It freaked me out and I figured my pregnancy was suppressing my immune system so my reactions would be more severe.
Now aside from an extremely itchy mouth, throat, and ears my frenulum is still swelling though just to the size of a pea. But what’s worse is my throat gets so uncomfortable. Almost like heartburn, but more like I have a huge vitamin pill stuck in there. Will there be a day where I get no reaction or will I just constantly be uncomfortable and paranoid that I will have to use my epi-pen?
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2024.04.24 15:08 resilience410 To Medicate or Not?

Things You Should Think About When Considering Medication
Despite the positive experience I had getting on medication, I don’t immediately push the idea of medication at my clients. If someone has been in therapy with me for six months or longer and they haven’t seen a reduction of their significant depression and/or anxiety I may suggest it but as it was with me, the decision is theirs. I may push harder if someone has severe depression/anxiety.
If a client decides to go forward I suggest a psychiatrist who I know to be proficient presuming their insurance will cover. If not, I have the client develop a list of three providers that will accept their insurance and I research them. If the client is in recovery, I make sure that they agree to tell their psychiatrist this important information up front. I encourage the client to understand that the overall goal is to find the right medication at the right dose. I counsel patience knowing that many medications may take six to eight weeks to build to therapeutic benefit. Often a medication is ineffective at a starting dose, so a higher one is tried. If there is still no or minimal benefit, then a new medication may be tried. It can be a difficult and lengthy process of trial and error that requires patience and frustration tolerance.
I encourage clients to take their medication consistently and precisely as directed. Clients with addictions issues need to understand the importance of not free-styling their dose by taking an extra pill because they’re struggling with an anxious day. If the directions are to take the medication at night on a full stomach, then that’s what you do. Nor should clients quit a medication at the first sign of a side effect. Often side effects resolve over time. If they don’t then perhaps a dose should be lowered or the medication has to be abandoned all together.
What Does Success Look Like?
Success means a significant reduction of symptoms and either no side effects or side effects one can live with. Any side effect is outweighed by the benefit of the medication. Success means you feel like yourself just less depressed or anxious. Not amped or tranquilized. The reduction of symptoms enables you to better deal with your symptoms effectively.
You may still have symptoms but they are less likely to negatively affect you because the medication is enabling you to manage. As one insightful friend described it, “my analogy is my anxiety was like really loud music playing all the time. It jacked up my emotions, my anxiety of course, but my anger, and my defensiveness too. Medication has turned the music way down so I can think about what I should do rather than just reacting to things all the time.”
I added, “When the music is really loud it distorts our ability to hear clearly what others are saying to us.” With the music roaring we exist in a constant state of fight or flight. Constructive criticism comes across as mean-spirited, threatening or insulting and we react accordingly. With effective medication we can hear the message as it's intended and take it to heart. Our relationships improve accordingly.
Pre-Seroquel and Lexapro, my anxiety often overwhelmed me to the point where I often avoided social contact, had sleepless nights and it affected my relationships adversely. I was irritable and then felt guilty for not treating people better. Today that’s rarely the case. With my anxiety consistently at the lower end of the scale, I can easily put my coping skills in play. I am more emotionally stout and just plain happier. If you decide to go on medication, I hope your experience is like mine!
A quick Checklist of Factors to Consider About Going on Medication
  1. Remember it's your decision to go medication. You can stop anytime. It's your body and your life.
  2. If possible, see a psychiatrist to evaluate you and formulate a prescription. If you can't see a psychiatrist, perhaps your MD is willing to prescribe. Many doctors are proficient in managing mild to moderate depression or anxiety. If you're dealing with BiPolar, severe depression or anxiety or other then you should find a psychiatrist.
  3. If you are in recovery from addictions, ALL your providers need to know from the outset that you're recovering. This should include your therapist, PCP, psychiatrist, dentist and providers in the emergency room. This is to prevent you from being prescribed addictive drugs such as benzodiazepine, opiates etc. If you have severe pain it can be carefully managed on an as-needed basis.
  4. Take your medication exactly as prescribed. If the medication is to be taken at night on a full stomach, then stick to that routine. Develop a system to take your medication consistently. There are inexpensive pill organizers to help organize you at most pharmacies. Do not skip doses because you feel good or add doses because you don't.
  5. Make sure you give the medication a trial equivalent to what the provider says is the time required to build to therapeutic levels. If this information isn't volunteered, ask! If you experience severe side effects stop the medication and call your provider right away. You may experience mild side effects but these may resolve over time. Try to give the medication a chance.
  6. Understand that providers may need to titrate your medication to help remit your symptoms so be patient.
  7. Continue all self-care routines including maintaining work/life balance, getting sufficient sleep, good nutrition and exercise.
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2024.04.24 11:18 Rahkrahk Cereno has presented results that look better than Sotatercept/Winrevair in PAH and are also going after thrombosis with first candidates that do not cause bleeding

This is my DD of Cereno Scientific.
Disclosure: I own the stock and this is not financial advice but a best effort to provide information and share some own current views as a start for individuals capable of doing their own due diligence. As well as hopefully discuss the case.
TLDR: This is the story of an under the radar Swedish biotech company led by ex big pharma heavy-hitters, partnered with big pharma as well as officially supported by top global key opinion leaders (KOL) within cardiovascular disease (CVD) that has patented an already is a safe, tolerable and established therapeutic since it has been shown to be efficacious against thrombosis, the #1 killer in the world. Furthermore, the company ALSO looks set to outperform established pulmonary arterial hypertension (PAH) drugs, even the new Sotatercept/Winrevair, which has an estimated $2-9B peak annual sales. Wait until you see the results, including already reported interim data on the majority of the patients in the soon to be completed phase II study.
The serendipitous mistake The founder of Cereno Scientific is Sverker Jern, a renowned Swedish cardiologist with books published about ECG, etc. Long story short, while trying to find out a way to restore the human bodies inherent blood clot preventing system, a "failed" experiment of a postdoc belonging to Jern´s lab led to the discovery that valproic acid (VPA) significantly inhibits HDAC. In turn, this significantly reduces PAI-1 while simultaneously increasing endogenous levels of tPA; both central to combating thrombosis. VPA has been around and used for treating epilepsy, bipolar disease, migraine etc. since the 1960's. While high enough dosages (typically much higher than used here) can come with adverse effects, VPA is established as a safe and tolerable therapeutic still prescribed today. Having developed a unique administration regime for VPA trough delayed-release to reduce PAI-1, which is elevated in the morning, Cereno created it´s first medical candidate, CS1. Since then, it has been shown to be safe and tolerable, reduces the levels of circulating PAI-1 as well as restore the levels of t-Pa in a phase I human trial, without increasing the risk of bleeding. Now, for those not familiar with the hematologic landscape, this is huge. The reason being that ALL existing therapeutics for thrombosis are double-edged swords that do increase this risk, causing considerable consequences for quality of life, not to mention fatal incidents. Coupled with thrombosis as the #1 underlying cause of death globally, it is not for nothing that a potential solution to this has been called the holy grail of medicine.
Global KOL's join Having made the discovery, patented it and demonstrated results in human, the company soon garnered the attention of a number of KOL´s. A scientific advisory board (SAB) was established comprised of leading global experts within CVD. Names such as Deepak Bhatt, Raymond Benza, Bertram Pitt, Faiez Zannad, Gordon Williams and Gunnar Olsson. Do look them all up. On the march towards a subsequent phase II trial for CS1, the course was initially set to directly target the medical indication thrombosis. However, following advice from the SAB, a strategical move to proving an even broader efficacy, shorten the time to market, thus preserving capital and prolonging IP rights, was chosen instead - for now - PAH.
The genius rationale behind proving broader efficacy quicker through PAH Although PAH is classified as a rare disease, the market is extensive and growing rapidly. The pathophysiology is simplified as this: Due to various etiologic backgrounds, a few being genetic, related to vascular fibrosis, inflammation, etc. the pulmonary arteries undergo constant proliferation. As they progressively become narrower, stiffer and less flexible, the pulmonary pressure is raised causing the right-hand side of the heart to also proliferate in order to pump enough oxygenated blood until there is simply no more room at which point the heart fails and the patient dies. Up until a few weeks ago (we will return to this), only simple vasodilators such as PDE5i´s which only temporarily alleviate symptoms, have been prescribed. Now, on top of the anti-thrombotic properties, it has also been established that CS1 has anti-fibrotic, anti-inflammatory, pulmonary pressure-relieving properties as well as reverse-remodeling of underlying pathological vascular changes. As the CEO of Cereno Sten Sörensen states - "CS1 fits like a hand in a glove for PAH". As a parenthesis, Sörensen successfully led the RALES study at Monsanto as well as MERIT-HF at AstraZeneca. Both aimed at expanding the use for already existing compounds, just like with CS1. As an incentive to formulate treatments for rare diseases, the FDA/EMA can grant Orphan Drug Designation (ODD). The benefits, if approved, are multifold but what is of most importance here are simplified regulatory pathways to get to market. For instance, 7 years market exclusivity is also granted but the company already has extensive patents in place. Cereno was granted ODD by the FDA in 2020. If this is deemed as a tactical sound move, the next part ought to be considered a strategical masterclass. First a bit of necessary background to make it understandable: Phase I is to evaluate safety and tolerability. Phase II trials expand on this with a larger patient sample size, as well as incorporate one or a few efficacy markers. The phase II study of Cereno is setup to measure approximately 30 of them. Why? For the sake of keeping this short, CS1 ("optimized" VPA) is an HDACi and it's mode of action is through epigenetic modulation. VPA has already in numerous studies throughout the years been found to positively impact risk markers for several CVD's and research revolving around HDACi's in general has picked up tremendous speed also in areas such as cancer treatment. It is effectively a form of gene therapy. While Cereno has specifically patented VPA, the company has additionally managed to patent ALL forms of HDACi, not only for thrombosis but also for improving endogenous fibrinolysis which could possibly be relevant for all forms of CVD but certainly for several broad indications such as heart failure, myocardial infarction and atherosclerosis. Hence, this phase II study is officially targeting PAH through markers such as mean pulmonary arterial pressure (mPAP) and 6 minute walking distance (6MWD) since everything points to that this should be a fast-forwarded slam dunk - but also incorporates markers relevant for other major indications - including PAI-1 for thrombosis. So, what started off as a mission to prove efficacy for "only" thrombosis has turned into a phase II study that will shine light on an avenue a lot broader, all at once.
In order to demonstrate this, the study participants are evenly distributed across three groups and administered one of three doses:
  1. A low dose, the same dose that reduced PAI-1 and showed anti-thrombotic properties, to confirm what was shown in Ph1.
  2. The dose shown in animal models to be clinically relevant for PAH by alleviating hypertension and show reverse remodeling capacity.
  3. Double the second dose to see whether an even higher dose means more effect and also to possibly show a dose response pattern.
I.e. a "perfect score" would be to demonstrate effects in 33% to 66% of the total number of patients depending on if dose #2 or #3 is enough in human. Regarding safety and tolerability, even the highest dose is lower than what is typically used for treating epilepsy. Furthermore, since PAH is a deadly disease with a very poor prognosis that lacks the possibility of significant spontaneous remission (patients do not get better without intervention, instead tend to progressively get worse), placebo is only formally to be included in the subsequent phase III trial and deemed unnecessary by the FDA in the ongoing Ph2 trial due to the known safety profile of VPA.
Big pharma Abbott partners with Cereno While planning for the phase II trial, Cereno and Abbott announced a mutual partnership for the same to which Abbott is to supply their CardioMEMS HF implanted sensor to Cereno's patients. The implications being multifold but mainly that instead of being bound to a few select measurements through right heart catheterization (RHC), the study now monitors many of the markers in real time. Measuring mPAP with CardioMEMS is highly superior to RHC due to the numerous measurements taken daily in comparison to RHC that is otherwise done only 3-4 times during a full trial. Due to the individual variability in the patients, RHC would demand 4 times as many patients to be able to detect the same difference in mPAP as with CardioMEMS. Further solidifying CardioMEMS as an improved health monitor by choosing Cereno and their extensive study protocol as a partner benefits Abbott.
The patents stand their ground - and Cereno scoops up two additional candidates In 2018, University of Michigan (UoM) filed for a patent for the usage of VPA to treat and/or prevent heart disease. This claim was rejected due to one (WO201605579) of the multiple patent families in place by Cereno. What then took place is beautiful:
​
  1. UoM licenses their own medical candidate ML585, renamed to CS585 to Cereno. A prostacyclin (IP) receptor agonist.
  2. Cereno is contacted by Emeriti Bio, (comprised of a group of legends behind multiple blockbusters such as Losec), and acquires CS014, a next generation VPA analogue. Data points to an even better safety profile than CS1, giving Cereno a potential next, next (2x) generation compound.
  3. Michael Holinstat at UoM, and the inventor of CS585, has later been engaged as the Director of translational research at Cereno to evaluate these assets through the preclinical stages of development. And both have shown to prevent thrombosis without the risk of bleeding in all research so far. In other words, Cereno is now in possession of what seems to be the only compounds in the world capable of addressing thrombosis without increasing the risk of bleeding. Seemingly three times the holy grail. Data confirming this has since been shown at the worlds most prestigious CVD conferences (ESC, ASH, ACC, BIO-EUROPE, PVRI, NAHC, CVCT, NLSDays, ISTH, EHA, etc.). Patents are already granted for all candidates.
“Remarkable!” results Since Cereno has already demonstrated efficacy for thrombosis (PAI-1), this metric should be a given success yet again and are measured once the study nears completion. But let's dive into the ones related to PAH since these are continually measured by the CardioMEMS device: During summer of -23, Cereno was contacted by one of the clinics involved, inquiring Cereno to pursue an abstract at the upcoming American Heart Association congress that was being held November -23. The first patient to complete the trial was done and had what seemed like an astounding improvement in symptoms. Cereno instead opted to communicate the results seen so far to the market. The results from the first patient? 30% reduction in mPAP. 20% improvement in Cardiac Output (CO). Improvement in WHO Functional Class (FC) from II to I, meaning from having debilitating symptoms to basically being able to live a normal life. Judging from the most prominent PAH trials, patients starting from FC III usually yield greater results than the ones starting from II. Meaning that data points to potentially even more efficacy to be tapped than for this patient. Or, as Raymond Benza, knighted director of pulmonary hypertension at Mt. Sinai Hospital in New York and principle investigator of the study and member of Cereno's SAB stated: "We were hoping for a 10% reduction (in mPAP) - here we saw a 30% reduction - That is really remarkable!"
Competitor analysis To keep this short, the only relevant reference to compare CS1 to is Sotatercept (now Winrevair). Approved by the FDA March 26th, it does come with risks of treatment adverse events such as increased risk of bleeding, hypertension, erythrocytosis, etc. but is still a significant step forward for patients suffering from PAH. Central to evaluating efficacy in PAH is PVR and 6MWD. PVR is calculated (PVR=80(mPAP-mPAWP/CO)) once the study is completed. So far there is both mPAP and CO from the first patient. 6MWD is also communicated at study completion. But already in the first patient, Cereno demonstrated better efficacy in PAH for relevant markers than ever previously seen. The important marker CO was not improved at all by Sotatercept. The onset (time from first dose to effects) of CS1 is also quicker. And the administration comes in the form of a pill instead of injectables, which is easier for patients. Furthermore, on March 27th, CNN writes this about Sotatercept: “In animal studies conducted before the human trials, the drug looked like it could do more than just treat symptoms: It seemed like it might be able to stop the thickening of the blood vessels and perhaps prolong patients’ lives, but those benefits have not been proven in humans.” Now back to what Dr. Raymond Benza has to say about CS1 on the subject: "Our effect on resistance was much more than what would be expected just with the effect in cardiac output. That means that this vessel is actually remodeling, and the resistance is coming down through a change in architecture of the vessel. That is really exciting to me".
Also, CS1 did all this in half the time compared to Sotatercept (12 vs 24 weeks).
A fluke? Interim findings are in and the answer is unequivocally no The apparent question surfaced - Exceptional results, but was this a one-time fluke? During fall of -23, Cereno announced interim findings (as a part of a DQCR) for 16 of the to be 30 patients including the following (in ""):
​
  1. "More than 60% of patients on CS1, all doses included, have a sustained reduction in mPAP." In other words, somewhere around 100% of the patients aimed for in a best case scenario.
  2. "An efficacy response compatible with a dose-response pattern." Being an open study, it would be logical to deduce that there seems to be three distinct differences in dose-response, as per the dosage protocol.
  3. *"Several patients with a reduction in mPAP of similar or greater magnitude as the initial Patient Case".*This speaks for itself.
  4. "The DQCR indicates an early onset of action". Patient #1 saw onset at 6 weeks but here is stated that "this early onset was observed already after 3 weeks for several patients". In comparison, onset for existing PAH medications apart from simple vasodilators is typically 12-15 weeks.
  5. "The DQCR showed a sustained reduction of mPAP in the 2-week follow-up period after the 12-week period of therapy with CS1 was discontinued." Indicating that a remodeling effect on the vessels has indeed taken place trough epigenetic modulation.
Again, the literature is clear; Patients with PAH just tend to get worse and simply do not see these results without intervention.
Cereno is granted "Compassionate use" by the FDA Having continued to demonstrate remarkable results also in the interim analysis, Cereno communicated to the market that they were now receiving even more inquiries from the clinics involved in the current study. This time stemming from a wish from both patients and treating clinicians to be able to continue with CS1 after the study ends. Expanded access/compassionate use, can be granted when faced with a severe condition where no good alternative medications exist, and if the FDA deems the demonstrated benefits as good enough. Cereno applied late -23. The FDA approved in January -24 and by this time Cereno also communicated that they now had been informed that the majority of the patients in the study would like to be able to continue with CS1. Apart from already being obvious exceptional news, this enables Cereno to generate a dataset for CS1 orders of magnitude more vast, since it will be possible to study even longer term results already now during phase II. As some may know, the dataset is everything when it comes to value.
Risks & critique What if the phase II study fails? CS1 and its pioneering approach has already been documented to show significant decrease in PAI-1 in human and has shown proof of concept in preclinical models in PAH by reducing the pressure in the vessels and achieving reverse remodeling. The company has also already communicated findings related to PAH for the majority of the patients in the current study which further support the findings seen in the preclinic. Look at them. Now do your own due diligence.
Why so cheap? The answer is probably twofold. First, although Cereno has operations in the US and the current study only uses US clinics, it is a Swedish biotech company still flying under the radar. There is a Swedish discord for the stock with some knowledgeable MD´s, scientists, etc. trying to explain what is going on but the majority of retail investors don’t seem to understand. Which brings us to second; institutional and professional investors typically enter post phase II results. According to Cereno, there is also already great interest from potential partners/buyers but the same goes here - phase II results first. The BoD and Management of Cereno have greatly increased their ownership exposure ever since presenting the results for patient #1 last year
Delay? Following Covid 19, there were administrative difficulties in starting up the nine clinics for the phase II trial resulting in the study being postponed and initial patient recruitment was also slow. To mitigate this, Cereno announced two additional clinics. The last of which should now be starting up at any time, since the company recently disclosed which one it is - Mt. Sinai Hospital, New York. Topline results are to be presented in Q3. The study is 12 weeks and had 26/30 patients enrolled by the last update in February. Hence, study completion could be delayed but given that only a maximum of 4 patients remain to be enrolled before end of June, it seems unlikely today. Since capital runway exists until spring -25, this should pose no vital threat regardless.
"Too much communication"? This is the only possibly negative feedback I've seen that has not yet been disproven. While I do think that many press releases in a short amount of time can sometimes pose more questions than they answer, in my opinion, this is not the case here. Having read them all, and while I do understand that not everyone is interested in which new country a patent has been accepted in or what events the the company will be attending, the rest is vital information. Cereno also sends copies of all press releases in English as well as Swedish, doubling the amount.
Wrapping up This only scratches the surface. If you are of a curious nature, maybe you will find interest in possible pieces to this puzzle such as that big pharma Bristol Myers Squibb (BMS) was engaged in buyout talks with Acceleron (Sotatercept) that was instead acquired by Merck. That Deepak Bhatt sits on the board of BMS - And now also in the SAB of Cereno.
But if nothing else, I think the following speaks for itself: The total addressable market (TAM) for PAH is projected to reach $12B by 2030.
The closest thing to a competitor (Sotatercept/Winrevair) was sold for approximately $7B after phase II. $8B today, adjusted for inflation. At the time of the acquisition, peak future sales was thought to come in at $2B. Since then, revised projections upwards of $9B have been made. The current market cap of Cereno Scientific is around $100M. Without speculating what a fair value should really be, that´s already a difference of around 80x. And compared to a lower peak sales than more recent projections. Plus, this is only from PAH, not counting thrombosis, with a TAM of 6x that of PAH. Cereno has already proven that CS1 can achieve results in PAH seen by no other therapeutic. And has already disclosed findings for the majority of the patients. The Phase II trial now only has a few patients left to recruit before completion.Cereno holds two additional candidates aimed at targeting thrombosis without bleeding, both seemingly unique and holding up so far. The TAM for thrombosis is projected to reach $70B by 2030. If Cereno replicates results for CS1 and PAI-1 a fourth(!) time, it would mean that their current PAH study also validates CS014 for thrombosis to quite some extent. Remember, they are both VPA. Bottom line – There are multiple shots at multiple staggering markets from one single study about to be completed – and the results so far are stellar.
submitted by Rahkrahk to Biotechplays [link] [comments]

2024.04.24 11:17 Rahkrahk DD: Cereno has presented results that look better than Sotatercept/Winrevair in PAH and are also going after thrombosis with first candidates that do not cause bleeding

This is my DD of Cereno Scientific.
Disclosure: I own the stock and this is not financial advice but a best effort to provide information and share some own current views as a start for individuals capable of doing their own due diligence. As well as hopefully discuss the case.
TLDR: This is the story of an under the radar Swedish biotech company led by ex big pharma heavy-hitters, partnered with big pharma as well as officially supported by top global key opinion leaders (KOL) within cardiovascular disease (CVD) that has patented an already is a safe, tolerable and established therapeutic since it has been shown to be efficacious against thrombosis, the #1 killer in the world. Furthermore, the company ALSO looks set to outperform established pulmonary arterial hypertension (PAH) drugs, even the new Sotatercept/Winrevair, which has an estimated $2-9B peak annual sales. Wait until you see the results, including already reported interim data on the majority of the patients in the soon to be completed phase II study.
The serendipitous mistake The founder of Cereno Scientific is Sverker Jern, a renowned Swedish cardiologist with books published about ECG, etc. Long story short, while trying to find out a way to restore the human bodies inherent blood clot preventing system, a "failed" experiment of a postdoc belonging to Jern´s lab led to the discovery that valproic acid (VPA) significantly inhibits HDAC. In turn, this significantly reduces PAI-1 while simultaneously increasing endogenous levels of tPA; both central to combating thrombosis. VPA has been around and used for treating epilepsy, bipolar disease, migraine etc. since the 1960's. While high enough dosages (typically much higher than used here) can come with adverse effects, VPA is established as a safe and tolerable therapeutic still prescribed today. Having developed a unique administration regime for VPA trough delayed-release to reduce PAI-1, which is elevated in the morning, Cereno created it´s first medical candidate, CS1. Since then, it has been shown to be safe and tolerable, reduces the levels of circulating PAI-1 as well as restore the levels of t-Pa in a phase I human trial, without increasing the risk of bleeding. Now, for those not familiar with the hematologic landscape, this is huge. The reason being that ALL existing therapeutics for thrombosis are double-edged swords that do increase this risk, causing considerable consequences for quality of life, not to mention fatal incidents. Coupled with thrombosis as the #1 underlying cause of death globally, it is not for nothing that a potential solution to this has been called the holy grail of medicine.
Global KOL's join Having made the discovery, patented it and demonstrated results in human, the company soon garnered the attention of a number of KOL´s. A scientific advisory board (SAB) was established comprised of leading global experts within CVD. Names such as Deepak Bhatt, Raymond Benza, Bertram Pitt, Faiez Zannad, Gordon Williams and Gunnar Olsson. Do look them all up. On the march towards a subsequent phase II trial for CS1, the course was initially set to directly target the medical indication thrombosis. However, following advice from the SAB, a strategical move to proving an even broader efficacy, shorten the time to market, thus preserving capital and prolonging IP rights, was chosen instead - for now - PAH.
The genius rationale behind proving broader efficacy quicker through PAH Although PAH is classified as a rare disease, the market is extensive and growing rapidly. The pathophysiology is simplified as this: Due to various etiologic backgrounds, a few being genetic, related to vascular fibrosis, inflammation, etc. the pulmonary arteries undergo constant proliferation. As they progressively become narrower, stiffer and less flexible, the pulmonary pressure is raised causing the right-hand side of the heart to also proliferate in order to pump enough oxygenated blood until there is simply no more room at which point the heart fails and the patient dies. Up until a few weeks ago (we will return to this), only simple vasodilators such as PDE5i´s which only temporarily alleviate symptoms, have been prescribed. Now, on top of the anti-thrombotic properties, it has also been established that CS1 has anti-fibrotic, anti-inflammatory, pulmonary pressure-relieving properties as well as reverse-remodeling of underlying pathological vascular changes. As the CEO of Cereno Sten Sörensen states - "CS1 fits like a hand in a glove for PAH". As a parenthesis, Sörensen successfully led the RALES study at Monsanto as well as MERIT-HF at AstraZeneca. Both aimed at expanding the use for already existing compounds, just like with CS1. As an incentive to formulate treatments for rare diseases, the FDA/EMA can grant Orphan Drug Designation (ODD). The benefits, if approved, are multifold but what is of most importance here are simplified regulatory pathways to get to market. For instance, 7 years market exclusivity is also granted but the company already has extensive patents in place. Cereno was granted ODD by the FDA in 2020. If this is deemed as a tactical sound move, the next part ought to be considered a strategical masterclass. First a bit of necessary background to make it understandable: Phase I is to evaluate safety and tolerability. Phase II trials expand on this with a larger patient sample size, as well as incorporate one or a few efficacy markers. The phase II study of Cereno is setup to measure approximately 30 of them. Why? For the sake of keeping this short, CS1 ("optimized" VPA) is an HDACi and it's mode of action is through epigenetic modulation. VPA has already in numerous studies throughout the years been found to positively impact risk markers for several CVD's and research revolving around HDACi's in general has picked up tremendous speed also in areas such as cancer treatment. It is effectively a form of gene therapy. While Cereno has specifically patented VPA, the company has additionally managed to patent ALL forms of HDACi, not only for thrombosis but also for improving endogenous fibrinolysis which could possibly be relevant for all forms of CVD but certainly for several broad indications such as heart failure, myocardial infarction and atherosclerosis. Hence, this phase II study is officially targeting PAH through markers such as mean pulmonary arterial pressure (mPAP) and 6 minute walking distance (6MWD) since everything points to that this should be a fast-forwarded slam dunk - but also incorporates markers relevant for other major indications - including PAI-1 for thrombosis. So, what started off as a mission to prove efficacy for "only" thrombosis has turned into a phase II study that will shine light on an avenue a lot broader, all at once.
In order to demonstrate this, the study participants are evenly distributed across three groups and administered one of three doses:
  1. A low dose, the same dose that reduced PAI-1 and showed anti-thrombotic properties, to confirm what was shown in Ph1.
  2. The dose shown in animal models to be clinically relevant for PAH by alleviating hypertension and show reverse remodeling capacity.
  3. Double the second dose to see whether an even higher dose means more effect and also to possibly show a dose response pattern.
I.e. a "perfect score" would be to demonstrate effects in 33% to 66% of the total number of patients depending on if dose #2 or #3 is enough in human. Regarding safety and tolerability, even the highest dose is lower than what is typically used for treating epilepsy. Furthermore, since PAH is a deadly disease with a very poor prognosis that lacks the possibility of significant spontaneous remission (patients do not get better without intervention, instead tend to progressively get worse), placebo is only formally to be included in the subsequent phase III trial and deemed unnecessary by the FDA in the ongoing Ph2 trial due to the known safety profile of VPA.
Big pharma Abbott partners with Cereno While planning for the phase II trial, Cereno and Abbott announced a mutual partnership for the same to which Abbott is to supply their CardioMEMS HF implanted sensor to Cereno's patients. The implications being multifold but mainly that instead of being bound to a few select measurements through right heart catheterization (RHC), the study now monitors many of the markers in real time. Measuring mPAP with CardioMEMS is highly superior to RHC due to the numerous measurements taken daily in comparison to RHC that is otherwise done only 3-4 times during a full trial. Due to the individual variability in the patients, RHC would demand 4 times as many patients to be able to detect the same difference in mPAP as with CardioMEMS. Further solidifying CardioMEMS as an improved health monitor by choosing Cereno and their extensive study protocol as a partner benefits Abbott.
The patents stand their ground - and Cereno scoops up two additional candidates In 2018, University of Michigan (UoM) filed for a patent for the usage of VPA to treat and/or prevent heart disease. This claim was rejected due to one (WO201605579) of the multiple patent families in place by Cereno. What then took place is beautiful:
​
  1. UoM licenses their own medical candidate ML585, renamed to CS585 to Cereno. A prostacyclin (IP) receptor agonist.
  2. Cereno is contacted by Emeriti Bio, (comprised of a group of legends behind multiple blockbusters such as Losec), and acquires CS014, a next generation VPA analogue. Data points to an even better safety profile than CS1, giving Cereno a potential next, next (2x) generation compound.
  3. Michael Holinstat at UoM, and the inventor of CS585, has later been engaged as the Director of translational research at Cereno to evaluate these assets through the preclinical stages of development. And both have shown to prevent thrombosis without the risk of bleeding in all research so far. In other words, Cereno is now in possession of what seems to be the only compounds in the world capable of addressing thrombosis without increasing the risk of bleeding. Seemingly three times the holy grail. Data confirming this has since been shown at the worlds most prestigious CVD conferences (ESC, ASH, ACC, BIO-EUROPE, PVRI, NAHC, CVCT, NLSDays, ISTH, EHA, etc.). Patents are already granted for all candidates.
“Remarkable!” results Since Cereno has already demonstrated efficacy for thrombosis (PAI-1), this metric should be a given success yet again and are measured once the study nears completion. But let's dive into the ones related to PAH since these are continually measured by the CardioMEMS device: During summer of -23, Cereno was contacted by one of the clinics involved, inquiring Cereno to pursue an abstract at the upcoming American Heart Association congress that was being held November -23. The first patient to complete the trial was done and had what seemed like an astounding improvement in symptoms. Cereno instead opted to communicate the results seen so far to the market. The results from the first patient? 30% reduction in mPAP. 20% improvement in Cardiac Output (CO). Improvement in WHO Functional Class (FC) from II to I, meaning from having debilitating symptoms to basically being able to live a normal life. Judging from the most prominent PAH trials, patients starting from FC III usually yield greater results than the ones starting from II. Meaning that data points to potentially even more efficacy to be tapped than for this patient. Or, as Raymond Benza, knighted director of pulmonary hypertension at Mt. Sinai Hospital in New York and principle investigator of the study and member of Cereno's SAB stated: "We were hoping for a 10% reduction (in mPAP) - here we saw a 30% reduction - That is really remarkable!"
Competitor analysis To keep this short, the only relevant reference to compare CS1 to is Sotatercept (now Winrevair). Approved by the FDA March 26th, it does come with risks of treatment adverse events such as increased risk of bleeding, hypertension, erythrocytosis, etc. but is still a significant step forward for patients suffering from PAH. Central to evaluating efficacy in PAH is PVR and 6MWD. PVR is calculated (PVR=80(mPAP-mPAWP/CO)) once the study is completed. So far there is both mPAP and CO from the first patient. 6MWD is also communicated at study completion. But already in the first patient, Cereno demonstrated better efficacy in PAH for relevant markers than ever previously seen. The important marker CO was not improved at all by Sotatercept. The onset (time from first dose to effects) of CS1 is also quicker. And the administration comes in the form of a pill instead of injectables, which is easier for patients. Furthermore, on March 27th, CNN writes this about Sotatercept: “In animal studies conducted before the human trials, the drug looked like it could do more than just treat symptoms: It seemed like it might be able to stop the thickening of the blood vessels and perhaps prolong patients’ lives, but those benefits have not been proven in humans.” Now back to what Dr. Raymond Benza has to say about CS1 on the subject: "Our effect on resistance was much more than what would be expected just with the effect in cardiac output. That means that this vessel is actually remodeling, and the resistance is coming down through a change in architecture of the vessel. That is really exciting to me".
Also, CS1 did all this in half the time compared to Sotatercept (12 vs 24 weeks).
A fluke? Interim findings are in and the answer is unequivocally no The apparent question surfaced - Exceptional results, but was this a one-time fluke? During fall of -23, Cereno announced interim findings (as a part of a DQCR) for 16 of the to be 30 patients including the following (in ""):
​
  1. "More than 60% of patients on CS1, all doses included, have a sustained reduction in mPAP." In other words, somewhere around 100% of the patients aimed for in a best case scenario.
  2. "An efficacy response compatible with a dose-response pattern." Being an open study, it would be logical to deduce that there seems to be three distinct differences in dose-response, as per the dosage protocol.
  3. *"Several patients with a reduction in mPAP of similar or greater magnitude as the initial Patient Case".*This speaks for itself.
  4. "The DQCR indicates an early onset of action". Patient #1 saw onset at 6 weeks but here is stated that "this early onset was observed already after 3 weeks for several patients". In comparison, onset for existing PAH medications apart from simple vasodilators is typically 12-15 weeks.
  5. "The DQCR showed a sustained reduction of mPAP in the 2-week follow-up period after the 12-week period of therapy with CS1 was discontinued." Indicating that a remodeling effect on the vessels has indeed taken place trough epigenetic modulation.
Again, the literature is clear; Patients with PAH just tend to get worse and simply do not see these results without intervention.
Cereno is granted "Compassionate use" by the FDA Having continued to demonstrate remarkable results also in the interim analysis, Cereno communicated to the market that they were now receiving even more inquiries from the clinics involved in the current study. This time stemming from a wish from both patients and treating clinicians to be able to continue with CS1 after the study ends. Expanded access/compassionate use, can be granted when faced with a severe condition where no good alternative medications exist, and if the FDA deems the demonstrated benefits as good enough. Cereno applied late -23. The FDA approved in January -24 and by this time Cereno also communicated that they now had been informed that the majority of the patients in the study would like to be able to continue with CS1. Apart from already being obvious exceptional news, this enables Cereno to generate a dataset for CS1 orders of magnitude more vast, since it will be possible to study even longer term results already now during phase II. As some may know, the dataset is everything when it comes to value.
Risks & critique What if the phase II study fails? CS1 and its pioneering approach has already been documented to show significant decrease in PAI-1 in human and has shown proof of concept in preclinical models in PAH by reducing the pressure in the vessels and achieving reverse remodeling. The company has also already communicated findings related to PAH for the majority of the patients in the current study which further support the findings seen in the preclinic. Look at them. Now do your own due diligence.
Why so cheap? The answer is probably twofold. First, although Cereno has operations in the US and the current study only uses US clinics, it is a Swedish biotech company still flying under the radar. There is a Swedish discord for the stock with some knowledgeable MD´s, scientists, etc. trying to explain what is going on but the majority of retail investors don’t seem to understand. Which brings us to second; institutional and professional investors typically enter post phase II results. According to Cereno, there is also already great interest from potential partners/buyers but the same goes here - phase II results first. The BoD and Management of Cereno have greatly increased their ownership exposure ever since presenting the results for patient #1 last year
Delay? Following Covid 19, there were administrative difficulties in starting up the nine clinics for the phase II trial resulting in the study being postponed and initial patient recruitment was also slow. To mitigate this, Cereno announced two additional clinics. The last of which should now be starting up at any time, since the company recently disclosed which one it is - Mt. Sinai Hospital, New York. Topline results are to be presented in Q3. The study is 12 weeks and had 26/30 patients enrolled by the last update in February. Hence, study completion could be delayed but given that only a maximum of 4 patients remain to be enrolled before end of June, it seems unlikely today. Since capital runway exists until spring -25, this should pose no vital threat regardless.
"Too much communication"? This is the only possibly negative feedback I've seen that has not yet been disproven. While I do think that many press releases in a short amount of time can sometimes pose more questions than they answer, in my opinion, this is not the case here. Having read them all, and while I do understand that not everyone is interested in which new country a patent has been accepted in or what events the the company will be attending, the rest is vital information. Cereno also sends copies of all press releases in English as well as Swedish, doubling the amount.
Wrapping up This only scratches the surface. If you are of a curious nature, maybe you will find interest in possible pieces to this puzzle such as that big pharma Bristol Myers Squibb (BMS) was engaged in buyout talks with Acceleron (Sotatercept) that was instead acquired by Merck. That Deepak Bhatt sits on the board of BMS - And now also in the SAB of Cereno.
But if nothing else, I think the following speaks for itself: The total addressable market (TAM) for PAH is projected to reach $12B by 2030.
The closest thing to a competitor (Sotatercept/Winrevair) was sold for approximately $7B after phase II. $8B today, adjusted for inflation. At the time of the acquisition, peak future sales was thought to come in at $2B. Since then, revised projections upwards of $9B have been made. The current market cap of Cereno Scientific is around $100M. Without speculating what a fair value should really be, that´s already a difference of around 80x. And compared to a lower peak sales than more recent projections. Plus, this is only from PAH, not counting thrombosis, with a TAM of 6x that of PAH. Cereno has already proven that CS1 can achieve results in PAH seen by no other therapeutic. And has already disclosed findings for the majority of the patients. The Phase II trial now only has a few patients left to recruit before completion.Cereno holds two additional candidates aimed at targeting thrombosis without bleeding, both seemingly unique and holding up so far. The TAM for thrombosis is projected to reach $70B by 2030. If Cereno replicates results for CS1 and PAI-1 a fourth(!) time, it would mean that their current PAH study also validates CS014 for thrombosis to quite some extent. Remember, they are both VPA. Bottom line – There are multiple shots at multiple staggering markets from one single study about to be completed – and the results so far are stellar.
submitted by Rahkrahk to biotech_stocks [link] [comments]

2024.04.24 09:52 Ok-Interaction-4293 Liv Pure Reviews (URGENT Official Website Update 2024) Fake Customer Risks Exposed!

In recent years, managing body weight has emerged as a significant concern for many. The journey towards a healthier lifestyle is often marred with misinformation and fleeting trends, making the path to effective weight management a challenging one. Amidst this backdrop, the conversation around weight management is incomplete without addressing the role of dietary supplements in facilitating a healthier, more balanced approach to weight loss.
As we delve deeper into the realm of dietary supplements, the importance of choosing the right aid becomes paramount. Among the myriad of options available, one particular supplement has begun to stand out for its innovative approach to weight management. This supplement, which we will explore in detail, promises to offer more than just a temporary fix; it aims to be a companion in the journey towards achieving and maintaining optimal health.
In the following sections, we will undertake a comprehensive exploration of this supplement, examining its composition, the science behind its formulation, and the experiences of those who have incorporated it into their wellness routines.

Basic Info- Liv Pure

Product Category: Weight Loss Supplement
Ingredients:
Liver Purification Complex:
Liver Fat-Burning Complex:
Benefits:
Pricing Options:
Single Bottle: $69 + shipping
Three Bottle Package: $147 + shipping
Six Bottle Bundle: $234 with free shipping
Money-Back Guarantee: 60-day, 100% money-back guarantee
Official Website:https://www.liv-pure.org/

Understanding Liv Pure: A Revolutionary Approach to Weight Loss

In an era where health consciousness is at its peak, Liv Pure emerges as a standout solution, catering to those in pursuit of a natural and effective path to weight loss. Unlike the traditional diet pills that rely on artificial means to stimulate weight loss, Liv Pure takes a holistic approach, ensuring the body’s optimal functioning through natural healing processes. This herbal formula is ingeniously crafted with two proprietary blends that serve dual purposes: enhancing metabolic efficiency and supporting the body’s intrinsic detoxification pathways.
The first of these blends focuses on purifying the body, particularly the liver, which is central to metabolic health. By improving liver function, Liv Pure addresses one of the root causes of weight gain and difficulty in losing weight. A healthy liver enhances the body’s ability to cleanse itself of toxins, which can otherwise hinder metabolic processes and lead to fat accumulation.
The second blend is designed to turbocharge the metabolism, assisting in the more efficient burning of calories. This is achieved not through the artificial stimulation of thermogenesis but by naturally enhancing the body’s calorie-burning capabilities. This method ensures that weight loss achieved with Liv Pure is sustainable and healthful, rather than being a mere result of forced and unnatural shedding of weight.
The creation of Liv Pure is the result of extensive research into the underlying causes of stubborn belly fat and weight gain. The team behind Liv Pure has meticulously selected ingredients known not only for their weight loss properties but also for their ability to support overall health. Each ingredient has undergone scientific scrutiny to validate its efficacy, ensuring that Liv Pure delivers on its promises.
What sets Liv Pure apart is its convenience and ease of use. Encapsulated in easy-to-swallow capsules, each bottle contains a month’s supply, designed to seamlessly integrate into daily routines without necessitating drastic changes in lifestyle, diet, or exercise regimes. The simplicity of taking a daily dose of Liv Pure makes it a practical choice for those looking to support their weight loss journey without additional stress or complexity.
Liv Pure stands as a testament to the power of natural supplementation in achieving weight loss. By focusing on enhancing liver function and boosting metabolism through natural means, Liv Pure offers a gentle yet effective path to weight management. This approach not only ensures immediate benefits in terms of weight reduction but also contributes to long-term health and well-being.

Unveiling the Mechanism: How Liv Pure Revolutionizes Weight Loss

In the realm of weight management, understanding the science behind a supplement is crucial in discerning its potential impact on one’s health journey. Liv Pure distinguishes itself from the plethora of weight loss aids through its innovative approach focused on enhancing liver functionality and overall metabolic health. This section delves into the operational dynamics of Liv Pure, providing insights into why this supplement might be the game-changer in the pursuit of a healthier lifestyle.
The liver, our body’s metabolic powerhouse, plays a pivotal role in processing everything we ingest. It’s responsible for metabolizing nutrients for energy and expelling toxins, thereby maintaining our body’s equilibrium. However, an overburdened liver, struggling under the weight of toxins and inflammation, can lead to a diminished capacity for fat metabolism. This is where Liv Pure steps in, with a mission to fortify liver health and, by extension, optimize the body’s natural weight loss mechanisms.
Crafted with a blend of 100% organic ingredients, Liv Pure targets the root causes of metabolic slowdown—primarily inflammation and toxin accumulation. By fostering a healthier liver, the supplement ensures that the liver efficiently processes food, segregates nutrients from waste, and prevents unnecessary fat storage. This approach is a testament to the thoughtfulness and research invested in Liv Pure’s formulation, aiming to rebalance the body’s internal processes for sustainable weight loss.
Liv Pure reviews often highlight its distinctive strategy of not just focusing on immediate weight loss but on initiating a deeper metabolic transformation. This commitment to improving liver health sets Liv Pure apart in a market flooded with quick fixes and superficial solutions. Users of Liv Pure have reported noticing a significant difference in how their bodies manage weight, attributing it to the enhanced liver functionality and metabolic efficiency promoted by the supplement

The Core of Vitality: Unpacking Liv Pure’s Ingredients

At the heart of Liv Pure’s revolutionary approach to weight loss and improved well-being is its meticulously curated blend of natural ingredients. Each component has been selected for its unique ability to support liver health, facilitate detoxification, and promote metabolic efficiency.
Liver Purification Complex: The Foundation of Wellness
Betaine: A naturally occurring compound in foods like spinach and beets, betaine stands out for its liver-supportive properties. It aids in the removal of fats from the liver, thus preventing fat accumulation and supporting liver function. Beyond liver health, betaine is linked to improved heart and digestive health, showcasing its multifaceted benefits.
Berberine: This compound is known for its remarkable ability to balance cholesterol levels, assisting in the reduction of bad cholesterol and the promotion of good cholesterol. Its contribution to weight management is significant, with studies suggesting its effectiveness in reducing waist circumference. Berberine’s anti-inflammatory properties further support liver healing, underscoring its critical role in metabolic health.
Glutathione: Hailed as one of the body’s most potent antioxidants, glutathione plays a crucial role in detoxifying the liver and supporting the regeneration of damaged cells. Its ability to clear toxins enhances the liver’s fat metabolism capabilities, integral for weight management and overall health
Silymarin: Derived from milk thistle, silymarin is celebrated for its liver-protective qualities. It not only has anti-inflammatory effects but also aids in liver regeneration and inhibits the development of chronic liver disease. Its benefits extend to improving insulin sensitivity, lowering cholesterol, and supporting skin, bone, cognitive, and immune health.
Molybdenum: This essential mineral, found in beans, grains, and lentils, activates enzymes critical for detoxification and metabolic processes. It underscores the intricate connection between essential nutrients and the body’s natural detoxification pathways.
Click Here to Get Liv Pure At Discounted Price!!!

Liver Fat-Burning Complex: Igniting Metabolic Fire

Camellia Sinensis: Best known as the plant used in various teas, Camellia Sinensis is rich in polyphenols that help eliminate free radicals. It boosts metabolism and fat oxidation, leading to a reduction in body fat percentage and an improvement in liver function, highlighting the role of natural antioxidants in weight management.
Choline: Essential for fat metabolism and liver regulation, choline supports liver function, detoxifies the body, and has anti-inflammatory effects. Its comprehensive benefits for liver health underscore its importance in the body’s metabolic processes.
Chlorogenic Acid: Found in fruits and vegetables, chlorogenic acid improves liver function by reducing inflammation and preventing fat accumulation. Its protective effects against liver damage demonstrate the power of natural compounds in maintaining liver health.
Genistein: This compound plays a role in hormonal regulation, impacting fat metabolism and weight loss. Its antioxidant and anti-inflammatory properties aid in liver regeneration and detoxification, showcasing the interconnectedness of hormonal balance, antioxidant support, and metabolic health.
Resveratrol: An antioxidant found in wine and grapes, resveratrol is known for its ability to reduce cholesterol and blood sugar levels, regulate blood pressure, and support gut health. Its anti-inflammatory properties contribute to a holistic approach to managing weight and enhancing liver function.
The ingenuity of Liv Pure lies in how these ingredients are combined to target liver health as a cornerstone of metabolic wellness and weight management. By supporting liver function, reducing inflammation, and enhancing detoxification, Liv Pure addresses the root causes of weight gain and metabolic slowdown.
Order Liv Pure Right Here At The Best Prices!!
submitted by Ok-Interaction-4293 to OxyBreathPro [link] [comments]

2024.04.24 09:38 PageComfortable2192 Liv Pure Reviews (URGENT Official Website Update 2024) Fake Customer Risks Exposed!

In recent years, managing body weight has emerged as a significant concern for many. The journey towards a healthier lifestyle is often marred with misinformation and fleeting trends, making the path to effective weight management a challenging one. Amidst this backdrop, the conversation around weight management is incomplete without addressing the role of dietary supplements in facilitating a healthier, more balanced approach to weight loss.
As we delve deeper into the realm of dietary supplements, the importance of choosing the right aid becomes paramount. Among the myriad of options available, one particular supplement has begun to stand out for its innovative approach to weight management. This supplement, which we will explore in detail, promises to offer more than just a temporary fix; it aims to be a companion in the journey
mulation, and the experiences of those who have incorporated it into their wellness routines.

Basic Info- Liv Pure

Product Category: Weight Loss Supplement
Ingredients:
Liver Purification Complex:
Liver Fat-Burning Complex:
Benefits:
Pricing Options:
Single Bottle: $69 + shipping
Three Bottle Package: $147 + shipping
Six Bottle Bundle: $234 with free shipping
Money-Back Guarantee: 60-day, 100% money-back guarantee
Official Website: https://cutt.ly/Jw1BMNjO

Understanding Liv Pure: A Revolutionary Approach to Weight Loss

In an era where health consciousness is at its peak, Liv Pure emerges as a standout solution, catering to those in pursuit of a natural and effective path to weight loss. Unlike the traditional diet pills that rely on artificial means to stimulate weight loss, Liv Pure takes a holistic approach, ensuring the body’s optimal functioning through natural healing processes. This herbal formula is ingeniously crafted with two proprietary blends that serve dual purposes: enhancing metabolic efficiency and supporting the body’s intrinsic detoxification pathways.
The first of these blends focuses on purifying the body, particularly the liver, which is central to metabolic health. By improving liver function, Liv Pure addresses one of the root causes of weight gain and difficulty in losing weight. A healthy liver enhances the body’s ability to cleanse itself of toxins, which can otherwise hinder metabolic processes and lead to fat accumulation.
The second blend is designed to turbocharge the metabolism, assisting in the more efficient burning of calories. This is achieved not through the artificial stimulation of thermogenesis but by naturally enhancing the body’s calorie-burning capabilities. This method ensures that weight loss achieved with Liv Pure is sustainable and healthful, rather than being a mere result of forced and unnatural shedding of weight.
The creation of Liv Pure is the result of extensive research into the underlying causes of stubborn belly fat and weight gain. The team behind Liv Pure has meticulously selected ingredients known not only for their weight loss properties but also for their ability to support overall health. Each ingredient has undergone scientific scrutiny to validate its efficacy, ensuring that Liv Pure delivers on its promises.
What sets Liv Pure apart is its convenience and ease of use. Encapsulated in easy-to-swallow capsules, each bottle contains a month’s supply, designed to seamlessly integrate into daily routines without necessitating drastic changes in lifestyle, diet, or exercise regimes. The simplicity of taking a daily dose of Liv Pure makes it a practical choice for those looking to support their weight loss journey without additional stress or complexity.
Liv Pure stands as a testament to the power of natural supplementation in achieving weight loss. By focusing on enhancing liver function and boosting metabolism through natural means, Liv Pure offers a gentle yet effective path to weight management. This approach not only ensures immediate benefits in terms of weight reduction but also contributes to long-term health and well-being.

Unveiling the Mechanism: How Liv Pure Revolutionizes Weight Loss

In the realm of weight management, understanding the science behind a supplement is crucial in discerning its potential impact on one’s health journey. Liv Pure distinguishes itself from the plethora of weight loss aids through its innovative approach focused on enhancing liver functionality and overall metabolic health. This section delves into the operational dynamics of Liv Pure, providing insights into why this supplement might be the game-changer in the pursuit of a healthier lifestyle.
The liver, our body’s metabolic powerhouse, plays a pivotal role in processing everything we ingest. It’s responsible for metabolizing nutrients for energy and expelling toxins, thereby maintaining our body’s equilibrium. However, an overburdened liver, struggling under the weight of toxins and inflammation, can lead to a diminished capacity for fat metabolism. This is where Liv Pure steps in, with a mission to fortify liver health and, by extension, optimize the body’s natural weight loss mechanisms.
Crafted with a blend of 100% organic ingredients, Liv Pure targets the root causes of metabolic slowdown—primarily inflammation and toxin accumulation. By fostering a healthier liver, the supplement ensures that the liver efficiently processes food, segregates nutrients from waste, and prevents unnecessary fat storage. This approach is a testament to the thoughtfulness and research invested in Liv Pure’s formulation, aiming to rebalance the body’s internal processes for sustainable weight loss.
Liv Pure reviews often highlight its distinctive strategy of not just focusing on immediate weight loss but on initiating a deeper metabolic transformation. This commitment to improving liver health sets Liv Pure apart in a market flooded with quick fixes and superficial solutions. Users of Liv Pure have reported noticing a significant difference in how their bodies manage weight, attributing it to the enhanced liver functionality and metabolic efficiency promoted by the supplement.
Click here to visit the official website for Liv Pure >>>

The Core of Vitality: Unpacking Liv Pure’s Ingredients

At the heart of Liv Pure’s revolutionary approach to weight loss and improved well-being is its meticulously curated blend of natural ingredients. Each component has been selected for its unique ability to support liver health, facilitate detoxification, and promote metabolic efficiency.
Liver Purification Complex: The Foundation of Wellness
Betaine: A naturally occurring compound in foods like spinach and beets, betaine stands out for its liver-supportive properties. It aids in the removal of fats from the liver, thus preventing fat accumulation and supporting liver function. Beyond liver health, betaine is linked to improved heart and digestive health, showcasing its multifaceted benefits.
Berberine: This compound is known for its remarkable ability to balance cholesterol levels, assisting in the reduction of bad cholesterol and the promotion of good cholesterol. Its contribution to weight management is significant, with studies suggesting its effectiveness in reducing waist circumference. Berberine’s anti-inflammatory properties further support liver healing, underscoring its critical role in metabolic health.
Glutathione: Hailed as one of the body’s most potent antioxidants, glutathione plays a crucial role in detoxifying the liver and supporting the regeneration of damaged cells. Its ability to clear toxins enhances the liver’s fat metabolism capabilities, integral for weight management and overall health.
Silymarin: Derived from milk thistle, silymarin is celebrated for its liver-protective qualities. It not only has anti-inflammatory effects but also aids in liver regeneration and inhibits the development of chronic liver disease. Its benefits extend to improving insulin sensitivity, lowering cholesterol, and supporting skin, bone, cognitive, and immune health.
Molybdenum: This essential mineral, found in beans, grains, and lentils, activates enzymes critical for detoxification and metabolic processes. It underscores the intricate connection between essential nutrients and the body’s natural detoxification pathways.
Click Here to Get Liv Pure At Discounted Price!!!
submitted by PageComfortable2192 to OxyBreathPro [link] [comments]

2024.04.24 01:11 fallingback_toearth Ineffective rx, why?!

I apologize in advance as I’m am certain this topic has been discussed a million times already, but I’m not finding a thread on my specific situation…I have been taking Vyvanse 30 mg for several months and it has 0 effect besides some appetite suppression. Even early on I felt nothing other than occasional difficulty sleeping. I know this is against medical advice but I took 1.5 pills before and still nothing. Before I switched to Vyvanse I was taking 20 mg Adderall with similar aka non existent effects.
I was prescribed 50 mg Vyvanse over 10 years ago and it worked great and made a noticeable difference. I’m perplexed as to why it’s not working now and hearing the rumors on social media are making me really think something w the formulation has changed. I do drink a cup or two of coffee in the morning and take the pill about an hour later on an otherwise empty stomach but I did the same thing 10 years ago. I guess I need to try without coffee…
Anyone else in a similar situation? Any ideas what the issue(s) could be? Is it simply not strong enough? I’d prefer the lowest effective dose and thought 50 was pretty high which is why I started with 30 mg…it’s frustrating to pay so much and not see an improvement.
Thanks for any advice!
submitted by fallingback_toearth to ADHD [link] [comments]

2024.04.23 22:14 ahhhhpanicin I think I have quiet BPD and I wanted to share my thoughts

To clarify this is not self diagnosing. I am writing this only as a way of venting and in hopes of people being able to relate or give advice. I am 18 and have been researching the quiet subtype of BPD, on and off for over a year. I think I fit the criteria for a diagnosis but obviously I was 17 when I started looking into this and even now at 18 I am quite young for a diagnosis. As well as this I am still on the NHS neurodevelopmental pathway for ASD and ADHD and have been waiting to see someone for over two years on this.
I want to start this by telling you some of the things I was told after a brief psychiatric assessment that was given in February - may 2023. She wrote a discharge letter and briefly explained some of the issues I am dealing with as I told her in person and had written her an email explaining more. I am doing this because honestly, it's easier than explaining every facet myself and afterwards I'll fill in any of the gaps.
I cnped the letter and then removed bits and pieces not relevant: “Josh is aged 17 and he is moving on to college to complete BTEC qualifications with a view perhaps to studying Architecture at university. Josh has struggled for some years in fully engaging with education. It is likely that his plans and aspirations may change over the coming years. He finds it difficult to focus on academic studies because of his long-standing psychological difficulties. Josh has been referred by his previous school, where he completed his GCSEs at the end of Year 11 in May/June 2022, to the NHS Neurodevelopmental Pathway. Josh and his mother perceive that Josh presents with symptoms of both a social communication disorder (ASD – ICD10 F84.0) and ADHD (ICD10 F90).
Secondary to Josh’s underlying neurodevelopmental difficulties, Josh also presents with marked symptoms of anxiety and low mood. Josh presents with initial insomnia, struggling to get to sleep and therefore finding it difficult to get up the next day to participate in education and any relevant activities. Josh experiences symptoms of depersonalisation/derealisation. Josh experiences visual hallucinations, e.g. seeing what he describes as “shadow men” out of the corner of his eye which I think are related to symptoms of anxiety as Josh denies any experimentation or use of substances or alcohol.
Josh presents with Gender Identity Disorder. He uses the Progestogen-only pill and wears binders. He is keen to be referred to a Gender Disorder Clinic that can prescribe hormone treatment as a first step before gender reassignment surgery.
In addition to Josh’s symptoms of anxiety and low mood, he also has symptoms of OCD (ICD10 F42). He has concerns about germs, and can worry that what he has been given to eat, even food cooked by his mother, may make him ill. Josh only eats a limited diet, focused primarily on pasta and cheese at his mother’s house and potato-based foods when he visits his father.
Josh finds it difficult to make and maintain friends. He can be quite black and white in his approach, perfectionistic and rigid. Josh does not easily cope well with transitions or unexpected alterations to his routine. He struggles with eye contact and empathy and experiences a range of sensory sensitivities. Josh is also aware that he struggles to attend and concentrate, finds it hard to focus, can be disorganised and struggles to stay on task.
FAMILY HISTORY mum and dad during their relationship had two children:
• Josh, the subject of this letter, aged 17 and repeating Year 12 at Sixth Form College in September 2023. Josh has identified as being of male gender for some time and is hoping when he turns 18 for greater support from the Gender Identity Disorder Clinic.
• brother, aged 15 and just completing Year 10 at Christleton High School. He has also been referred to the NHS Neurodevelopmental Pathway for ADHD/ASD assessments.
FAMILY HISTORY OF PSYCHIATRIC DISORDER
dad presents with some symptoms of anxiety and depression and may present with symptoms of complex PTSD according to mother’s account as a result of his adverse early life experiences.
mum suffered symptoms of PTSD and depression following a termination when she was aged 18. At 40 she experienced an acute psychotic episode and benefitted from intensive CBT, Sertraline SSRI antidepressant medication and support from her parents.
Josh is already prescribed Promethazine 50mg at night by his GP to help him sleep.
PERSONAL DEVELOPMENT
Josh experiences marked emotional lability, at times being quiet, withdrawn and depressed, spending most of his time in his bedroom and at other times being restless, fidgety and unable to calm down and concentrate on studies or hobbies. Josh is aware from his own account that he struggles to make and maintain friends. The only person with whom he has a close relationship where he can be open about his experience of intrusive thoughts, visual hallucinations and thoughts of suicidal intent, is his boyfriend to whom he speaks on a daily basis.
Josh’s mother wrote to me after my last session, describing Josh as being sad and depressed long-term Indeed, she said, “Always looked like he had the world on his shoulders, hated himself, felt he did not quite fit in. He was not like others. Withdraws in situations he finds difficult, even at family events either will not go or soon takes himself off into another room to be alone as it becomes too much. He is visibly anxious in social situations, does not like to be touched. He finds it hard to understand what others are thinking and feeling and hard to read other people’s emotions”. She also commented that Josh often found it so difficult to talk about his feelings and emotions that he would text her to express concerns, e.g. in relation to thoughts of suicidal intent rather than talking to her.
FORMULATION
It is, unfortunately, not possible to organise these assessments privately. A formal diagnosis of neurodevelopmental difficulties has not been reached following this initial assessment but it is evident that Josh has complex difficulties.
In the meantime, Josh would benefit from re-referral to Tier 3 CAMHS and the introduction of SSRI antidepressant medication such as Sertraline to help manage his anxiety. “
Sorry I know that was long, I didn't know what to keep. Instead of going to tier 3 camhs I was put on the list for adult NHS mental health care and they referred me to a workshop called “beating psychological distress using DBT skills” which is a 6 week course I am currently on week 4 of.
I have a fear of abandonment that I think comes from multiple angles. As a kid I was bullied for 6-7 years and after that I was still always treated differently, of course also growing up undiagnosed was also inherently traumatic as well as growing up trans I never really felt seen. As well as this, me and my mum have never had a good relationship and I don't remember much about my life but I will never forget that my mum would always threaten to leave me at my dads and never return, nearly every weekend before I would visit him.
Normally my relationship with my friends and most of my family is quite stable. It isn't with my mum or my brother we fight continuously. I also have a boyfriend and to be honest if her wasn't a passive person and was more willing to fight we wouldn't have stable relationship, but he kind of balances me out which at times i can find very annoying because i feel so guilty and think that he should be shouting at me that's what his reaction should be, he should be mad. He has autism though and says that he cannot feel anger like a neurotypical can.
My sense of self is horrendous, I have no idea who I am, I can use adjectives to describe me like trans, bi, etc but i can never convey myself further than that. I kind of just feel empty. Sometimes it feels like live isnt real and i just sometimes dont remember how i even got to the place i am or what happened in my life up to recent points. I do experience dissociation HARD and depersonalisation. I mean I think I have done that to my self though because I have always escaped from my feelings and thoughts by turning my brain off and watching tv or listening to music or something just so I didnt have to think.
My mood changes so much and it can change within seconds or withing hours, its never consistent throughout the day, I could be deeply depressed and want to not be alive one minute then the next be hyper and mimic emotions of happiness.
I mean i am impulsive in some ways like for example I jumped of a 7-8 foot wall for no good reason and fucked up my ankle last week, and I have been impulsive with substances once or twice but nothing two extreme. I wouldn't necessarily say I fit this criteria. I think the impulsiveness is just my probable adhd. I am a nicotine addict tho… eek
I sh alot and i cut now but even before that I would itch my arm to the point it bleed or it came up with spots just to ease and distract me from my inner pain.
Persistent feelings of emptiness i kind of already said about when i talked about my self-image. My self image can also change with my mood swings. When im hyper i can gass myself up but then when im not im like omg ew yk.
I do have anger issues. Most of it is internalised and I just feel like screaming. At my mum i can take my anger out when we are arguing but thats because its just been that my whole life. I can also just explode and say things that I regret or just get so mad but that has to build up and that isnt very often.
I also have temporary paranoid thoughts. Poaranoial ideation, thinking everyone hates me, everyones against me, even thinking that everyone else in the world is fake and they all are just programmed to make my life hell and they all know what they are doing and find it funny… ik ridiculous haha.
I have never been one to speak out when I am suffering. My mum found out I was being bullied 5 years in because someone wrote something that made her suspicious on a birthday card I was given. Not because I was upset and I told her, no because someone else did. I have always suppressed my feelings and find it so hard to physically talk about what is wrong (hence why I message people if I can). I have become very good at research and for example, i have always had issues with reading and in primary school we got me tested for dyslexia. I didn't have it so nobody thought anything more about it, except me. High school got me struggling so I did some research and knew I had accommodative insufficiency and irlens syndrome, convinced my mum to get me tested and not only did I have both I also had convergence insufficiency. When I told my teacher that had taught me throughout the whole 5 previous years of high school she didn't believe me and said that because she taught me she knew I didn't struggle;I liked that and I had to show her the proof. I don't want people to know when I am struggling, I hide it, I distract myself, I direct it inwards, I withdraw and it has always been like that.
I don't know what exact I am doing writing this I just feel really shit right now because I know that even if i have this it will take years to get diagnosed and get that reassurance and until then I will always be questioning it, gaslighting myself that I am faking it and that I am not that bad.
Anyways that's it, if u read all of this than k you and please if you have the time share your thoughts with me in the comments.
submitted by ahhhhpanicin to mentalhealth [link] [comments]

2024.04.23 18:59 NewAdagio1657 Liv Pure Reviews (URGENT Official Website Update) Fake Customer Risks Exposed!

In recent years, managing body weight has emerged as a significant concern for many. The journey towards a healthier lifestyle is often marred with misinformation and fleeting trends, making the path to effective weight management a challenging one. Amidst this backdrop, the conversation around weight management is incomplete without addressing the role of dietary supplements in facilitating a healthier, more balanced approach to weight loss.
As we delve deeper into the realm of dietary supplements, the importance of choosing the right aid becomes paramount. Among the myriad of options available, one particular supplement has begun to stand out for its innovative approach to weight management. This supplement, which we will explore in detail, promises to offer more than just a temporary fix; it aims to be a companion in the journey towards achieving and maintaining optimal health.
In the following sections, we will undertake a comprehensive exploration of this supplement, examining its composition, the science behind its formulation, and the experiences of those who have incorporated it into their wellness routines.

Basic Info- Liv Pure

Product Category: Weight Loss Supplement
Ingredients:
Liver Purification Complex:
Liver Fat-Burning Complex:
Benefits:
Pricing Options:

Understanding Liv Pure: A Revolutionary Approach to Weight Loss

In an era where health consciousness is at its peak, Liv Pure emerges as a standout solution, catering to those in pursuit of a natural and effective path to weight loss. Unlike the traditional diet pills that rely on artificial means to stimulate weight loss, Liv Pure takes a holistic approach, ensuring the body’s optimal functioning through natural healing processes. This herbal formula is ingeniously crafted with two proprietary blends that serve dual purposes: enhancing metabolic efficiency and supporting the body’s intrinsic detoxification pathways.
The first of these blends focuses on purifying the body, particularly the liver, which is central to metabolic health. By improving liver function, Liv Pure addresses one of the root causes of weight gain and difficulty in losing weight. A healthy liver enhances the body’s ability to cleanse itself of toxins, which can otherwise hinder metabolic processes and lead to fat accumulation.
The second blend is designed to turbocharge the metabolism, assisting in the more efficient burning of calories. This is achieved not through the artificial stimulation of thermogenesis but by naturally enhancing the body’s calorie-burning capabilities. This method ensures that weight loss achieved with Liv Pure is sustainable and healthful, rather than being a mere result of forced and unnatural shedding of weight.
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2024.04.23 18:16 Rahkrahk DD: Cereno has presented results that look better than Sotatercept/Winrevair in PAH and are also going after thrombosis

This is my DD of Cereno Scientific.
Disclosure: I own the stock and this is not financial advice but a best effort to provide information and share some own current views as a start for individuals capable of doing their own due diligence. As well as hopefully discuss the case.
TLDR: This is the story of an under the radar Swedish biotech company led by ex big pharma heavy-hitters, partnered with big pharma as well as officially supported by top global key opinion leaders (KOL) within cardiovascular disease (CVD) that has patented an already is a safe, tolerable and established therapeutic since it has been shown to be efficacious against thrombosis, the #1 killer in the world. Furthermore, the company ALSO looks set to outperform established pulmonary arterial hypertension (PAH) drugs, even the new Sotatercept/Winrevair, which has an estimated $2-9B peak annual sales. Wait until you see the results, including already reported interim data on the majority of the patients in the soon to be completed phase II study.
The serendipitous mistake The founder of Cereno Scientific is Sverker Jern, a renowned Swedish cardiologist with books published about ECG, etc. Long story short, while trying to find out a way to restore the human bodies inherent blood clot preventing system, a "failed" experiment of a postdoc belonging to Jern´s lab led to the discovery that valproic acid (VPA) significantly inhibits HDAC. In turn, this significantly reduces PAI-1 while simultaneously increasing endogenous levels of tPA; both central to combating thrombosis. VPA has been around and used for treating epilepsy, bipolar disease, migraine etc. since the 1960's. While high enough dosages (typically much higher than used here) can come with adverse effects, VPA is established as a safe and tolerable therapeutic still prescribed today. Having developed a unique administration regime for VPA trough delayed-release to reduce PAI-1, which is elevated in the morning, Cereno created it´s first medical candidate, CS1. Since then, it has been shown to be safe and tolerable, reduces the levels of circulating PAI-1 as well as restore the levels of t-Pa in a phase I human trial, without increasing the risk of bleeding. Now, for those not familiar with the hematologic landscape, this is huge. The reason being that ALL existing therapeutics for thrombosis are double-edged swords that do increase this risk, causing considerable consequences for quality of life, not to mention fatal incidents. Coupled with thrombosis as the #1 underlying cause of death globally, it is not for nothing that a potential solution to this has been called the holy grail of medicine.
Global KOL's join Having made the discovery, patented it and demonstrated results in human, the company soon garnered the attention of a number of KOL´s. A scientific advisory board (SAB) was established comprised of leading global experts within CVD. Names such as Deepak Bhatt, Raymond Benza, Bertram Pitt, Faiez Zannad, Gordon Williams and Gunnar Olsson. Do look them all up. On the march towards a subsequent phase II trial for CS1, the course was initially set to directly target the medical indication thrombosis. However, following advice from the SAB, a strategical move to proving an even broader efficacy, shorten the time to market, thus preserving capital and prolonging IP rights, was chosen instead - for now - PAH.
The genius rationale behind proving broader efficacy quicker through PAH Although PAH is classified as a rare disease, the market is extensive and growing rapidly. The pathophysiology is simplified as this: Due to various etiologic backgrounds, a few being genetic, related to vascular fibrosis, inflammation, etc. the pulmonary arteries undergo constant proliferation. As they progressively become narrower, stiffer and less flexible, the pulmonary pressure is raised causing the right-hand side of the heart to also proliferate in order to pump enough oxygenated blood until there is simply no more room at which point the heart fails and the patient dies. Up until a few weeks ago (we will return to this), only simple vasodilators such as PDE5i´s which only temporarily alleviate symptoms, have been prescribed. Now, on top of the anti-thrombotic properties, it has also been established that CS1 has anti-fibrotic, anti-inflammatory, pulmonary pressure-relieving properties as well as reverse-remodeling of underlying pathological vascular changes. As the CEO of Cereno Sten Sörensen states - "CS1 fits like a hand in a glove for PAH". As a parenthesis, Sörensen successfully led the RALES study at Monsanto as well as MERIT-HF at AstraZeneca. Both aimed at expanding the use for already existing compounds, just like with CS1. As an incentive to formulate treatments for rare diseases, the FDA/EMA can grant Orphan Drug Designation (ODD). The benefits, if approved, are multifold but what is of most importance here are simplified regulatory pathways to get to market. For instance, 7 years market exclusivity is also granted but the company already has extensive patents in place. Cereno was granted ODD by the FDA in 2020. If this is deemed as a tactical sound move, the next part ought to be considered a strategical masterclass. First a bit of necessary background to make it understandable: Phase I is to evaluate safety and tolerability. Phase II trials expand on this with a larger patient sample size, as well as incorporate one or a few efficacy markers. The phase II study of Cereno is setup to measure approximately 30 of them. Why? For the sake of keeping this short, CS1 ("optimized" VPA) is an HDACi and it's mode of action is through epigenetic modulation. VPA has already in numerous studies throughout the years been found to positively impact risk markers for several CVD's and research revolving around HDACi's in general has picked up tremendous speed also in areas such as cancer treatment. It is effectively a form of gene therapy. While Cereno has specifically patented VPA, the company has additionally managed to patent ALL forms of HDACi, not only for thrombosis but also for improving endogenous fibrinolysis which could possibly be relevant for all forms of CVD but certainly for several broad indications such as heart failure, myocardial infarction and atherosclerosis. Hence, this phase II study is officially targeting PAH through markers such as mean pulmonary arterial pressure (mPAP) and 6 minute walking distance (6MWD) since everything points to that this should be a fast-forwarded slam dunk - but also incorporates markers relevant for other major indications - including PAI-1 for thrombosis. So, what started off as a mission to prove efficacy for "only" thrombosis has turned into a phase II study that will shine light on an avenue a lot broader, all at once.
In order to demonstrate this, the study participants are evenly distributed across three groups and administered one of three doses:
  1. A low dose, the same dose that reduced PAI-1 and showed anti-thrombotic properties, to confirm what was shown in Ph1.
  2. The dose shown in animal models to be clinically relevant for PAH by alleviating hypertension and show reverse remodeling capacity.
  3. Double the second dose to see whether an even higher dose means more effect and also to possibly show a dose response pattern.
I.e. a "perfect score" would be to demonstrate effects in 33% to 66% of the total number of patients depending on if dose #2 or #3 is enough in human. Regarding safety and tolerability, even the highest dose is lower than what is typically used for treating epilepsy. Furthermore, since PAH is a deadly disease with a very poor prognosis that lacks the possibility of significant spontaneous remission (patients do not get better without intervention, instead tend to progressively get worse), placebo is only formally to be included in the subsequent phase III trial and deemed unnecessary by the FDA in the ongoing Ph2 trial due to the known safety profile of VPA.
Big pharma Abbott partners with Cereno While planning for the phase II trial, Cereno and Abbott announced a mutual partnership for the same to which Abbott is to supply their CardioMEMS HF implanted sensor to Cereno's patients. The implications being multifold but mainly that instead of being bound to a few select measurements through right heart catheterization (RHC), the study now monitors many of the markers in real time. Measuring mPAP with CardioMEMS is highly superior to RHC due to the numerous measurements taken daily in comparison to RHC that is otherwise done only 3-4 times during a full trial. Due to the individual variability in the patients, RHC would demand 4 times as many patients to be able to detect the same difference in mPAP as with CardioMEMS. Further solidifying CardioMEMS as an improved health monitor by choosing Cereno and their extensive study protocol as a partner benefits Abbott.
The patents stand their ground - and Cereno scoops up two additional candidates In 2018, University of Michigan (UoM) filed for a patent for the usage of VPA to treat and/or prevent heart disease. This claim was rejected due to one (WO201605579) of the multiple patent families in place by Cereno. What then took place is beautiful:
  1. UoM licenses their own medical candidate ML585, renamed to CS585 to Cereno. A prostacyclin (IP) receptor agonist.
  2. Cereno is contacted by Emeriti Bio, (comprised of a group of legends behind multiple blockbusters such as Losec), and acquires CS014, a next generation VPA analogue. Data points to an even better safety profile than CS1, giving Cereno a potential next, next (2x) generation compound.
  3. Michael Holinstat at UoM, and the inventor of CS585, has later been engaged as the Director of translational research at Cereno to evaluate these assets through the preclinical stages of development. And both have shown to prevent thrombosis without the risk of bleeding in all research so far. In other words, Cereno is now in possession of what seems to be the only compounds in the world capable of addressing thrombosis without increasing the risk of bleeding. Seemingly three times the holy grail. Data confirming this has since been shown at the worlds most prestigious CVD conferences (ESC, ASH, ACC, BIO-EUROPE, PVRI, NAHC, CVCT, NLSDays, ISTH, EHA, etc.). Patents are already granted for all candidates.
“Remarkable!” results Since Cereno has already demonstrated efficacy for thrombosis (PAI-1), this metric should be a given success yet again and are measured once the study nears completion. But let's dive into the ones related to PAH since these are continually measured by the CardioMEMS device: During summer of -23, Cereno was contacted by one of the clinics involved, inquiring Cereno to pursue an abstract at the upcoming American Heart Association congress that was being held November -23. The first patient to complete the trial was done and had what seemed like an astounding improvement in symptoms. Cereno instead opted to communicate the results seen so far to the market. The results from the first patient? 30% reduction in mPAP. 20% improvement in Cardiac Output (CO). Improvement in WHO Functional Class (FC) from II to I, meaning from having debilitating symptoms to basically being able to live a normal life. Judging from the most prominent PAH trials, patients starting from FC III usually yield greater results than the ones starting from II. Meaning that data points to potentially even more efficacy to be tapped than for this patient. Or, as Raymond Benza, knighted director of pulmonary hypertension at Mt. Sinai Hospital in New York and principle investigator of the study and member of Cereno's SAB stated: "We were hoping for a 10% reduction (in mPAP) - here we saw a 30% reduction - That is really remarkable!"
Competitor analysis To keep this short, the only relevant reference to compare CS1 to is Sotatercept (now Winrevair). Approved by the FDA March 26th, it does come with risks of treatment adverse events such as increased risk of bleeding, hypertension, erythrocytosis, etc. but is still a significant step forward for patients suffering from PAH. Central to evaluating efficacy in PAH is PVR and 6MWD. PVR is calculated (PVR=80(mPAP-mPAWP/CO)) once the study is completed. So far there is both mPAP and CO from the first patient. 6MWD is also communicated at study completion. But already in the first patient, Cereno demonstrated better efficacy in PAH for relevant markers than ever previously seen. The important marker CO was not improved at all by Sotatercept. The onset (time from first dose to effects) of CS1 is also quicker. And the administration comes in the form of a pill instead of injectables, which is easier for patients. Furthermore, on March 27th, CNN writes this about Sotatercept: “In animal studies conducted before the human trials, the drug looked like it could do more than just treat symptoms: It seemed like it might be able to stop the thickening of the blood vessels and perhaps prolong patients’ lives, but those benefits have not been proven in humans.” Now back to what Dr. Raymond Benza has to say about CS1 on the subject: "Our effect on resistance was much more than what would be expected just with the effect in cardiac output. That means that this vessel is actually remodeling, and the resistance is coming down through a change in architecture of the vessel. That is really exciting to me".
Also, CS1 did all this in half the time compared to Sotatercept (12 vs 24 weeks).
A fluke? Interim findings are in and the answer is unequivocally no The apparent question surfaced - Exceptional results, but was this a one-time fluke? During fall of -23, Cereno announced interim findings (as a part of a DQCR) for 16 of the to be 30 patients including the following (in ""):
  1. "More than 60% of patients on CS1, all doses included, have a sustained reduction in mPAP." In other words, somewhere around 100% of the patients aimed for in a best case scenario.
  2. "An efficacy response compatible with a dose-response pattern." Being an open study, it would be logical to deduce that there seems to be three distinct differences in dose-response, as per the dosage protocol.
  3. "Several patients with a reduction in mPAP of similar or greater magnitude as the initial Patient Case".This speaks for itself.
  4. "The DQCR indicates an early onset of action". Patient #1 saw onset at 6 weeks but here is stated that "this early onset was observed already after 3 weeks for several patients". In comparison, onset for existing PAH medications apart from simple vasodilators is typically 12-15 weeks.
  5. "The DQCR showed a sustained reduction of mPAP in the 2-week follow-up period after the 12-week period of therapy with CS1 was discontinued." Indicating that a remodeling effect on the vessels has indeed taken place trough epigenetic modulation.
Again, the literature is clear; Patients with PAH just tend to get worse and simply do not see these results without intervention. Cereno is granted "Compassionate use" by the FDA Having continued to demonstrate remarkable results also in the interim analysis, Cereno communicated to the market that they were now receiving even more inquiries from the clinics involved in the current study. This time stemming from a wish from both patients and treating clinicians to be able to continue with CS1 after the study ends. Expanded access/compassionate use, can be granted when faced with a severe condition where no good alternative medications exist, and if the FDA deems the demonstrated benefits as good enough. Cereno applied late -23. The FDA approved in January -24 and by this time Cereno also communicated that they now had been informed that the majority of the patients in the study would like to be able to continue with CS1. Apart from already being obvious exceptional news, this enables Cereno to generate a dataset for CS1 orders of magnitude more vast, since it will be possible to study even longer term results already now during phase II. As some may know, the dataset is everything when it comes to value.
Risks & critique What if the phase II study fails? CS1 and its pioneering approach has already been documented to show significant decrease in PAI-1 in human and has shown proof of concept in preclinical models in PAH by reducing the pressure in the vessels and achieving reverse remodeling. The company has also already communicated findings related to PAH for the majority of the patients in the current study which further support the findings seen in the preclinic. Look at them. Now do your own due diligence.
Why so cheap? The answer is probably twofold. First, although Cereno has operations in the US and the current study only uses US clinics, it is a Swedish biotech company still flying under the radar. There is a Swedish discord for the stock with some knowledgeable MD´s, scientists, etc. trying to explain what is going on but the majority of retail investors don’t seem to understand. Which brings us to second; institutional and professional investors typically enter post phase II results. According to Cereno, there is also already great interest from potential partners/buyers but the same goes here - phase II results first. The BoD and Management of Cereno have greatly increased their ownership exposure ever since presenting the results for patient #1 last year
Delay? Following Covid 19, there were administrative difficulties in starting up the nine clinics for the phase II trial resulting in the study being postponed and initial patient recruitment was also slow. To mitigate this, Cereno announced two additional clinics. The last of which should now be starting up at any time, since the company recently disclosed which one it is - Mt. Sinai Hospital, New York. Topline results are to be presented in Q3. The study is 12 weeks and had 26/30 patients enrolled by the last update in February. Hence, study completion could be delayed but given that only a maximum of 4 patients remain to be enrolled before end of June, it seems unlikely today. Since capital runway exists until spring -25, this should pose no vital threat regardless.
"Too much communication"? This is the only possibly negative feedback I've seen that has not yet been disproven. While I do think that many press releases in a short amount of time can sometimes pose more questions than they answer, in my opinion, this is not the case here. Having read them all, and while I do understand that not everyone is interested in which new country a patent has been accepted in or what events the the company will be attending, the rest is vital information. Cereno also sends copies of all press releases in English as well as Swedish, doubling the amount.
Wrapping up This only scratches the surface. If you are of a curious nature, maybe you will find interest in possible pieces to this puzzle such as that big pharma Bristol Myers Squibb (BMS) was engaged in buyout talks with Acceleron (Sotatercept) that was instead acquired by Merck. That Deepak Bhatt sits on the board of BMS - And now also in the SAB of Cereno.
But if nothing else, I think the following speaks for itself: The total addressable market (TAM) for PAH is projected to reach $12B by 2030.
The closest thing to a competitor (Sotatercept/Winrevair) was sold for approximately $7B after phase II. $8B today, adjusted for inflation. At the time of the acquisition, peak future sales was thought to come in at $2B. Since then, revised projections upwards of $9B have been made. The current market cap of Cereno Scientific is around $100M. Without speculating what a fair value should really be, that´s already a difference of around 80x. And compared to a lower peak sales than more recent projections. Plus, this is only from PAH, not counting thrombosis, with a TAM of 6x that of PAH. Cereno has already proven that CS1 can achieve results in PAH seen by no other therapeutic. And has already disclosed findings for the majority of the patients. The Phase II trial now only has a few patients left to recruit before completion.Cereno holds two additional candidates aimed at targeting thrombosis without bleeding, both seemingly unique and holding up so far. The TAM for thrombosis is projected to reach $70B by 2030. If Cereno replicates results for CS1 and PAI-1 a fourth(!) time, it would mean that their current PAH study also validates CS014 for thrombosis to quite some extent. Remember, they are both VPA. Bottom line – There are multiple shots at multiple staggering markets from one single study about to be completed – and the results so far are stellar.

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2024.04.23 06:09 Soft_Goal802 Chapter 6: I, Ning Zhuo, Am Just Ordinary

With a hint of suspicion, Chen Cha subtly asked Ning Zhuo several questions. The questions covered various aspects that Ning Zhuo, not being the true creator, couldn't answer. Yet, this did not pose a challenge for Ning Zhuo. After the exchange, Chen Cha dismissed his doubts, feeling a stir in his heart, "Did he really design and make this?"
"Isn't he a junior of the Ning family? The Ning family excels in talismans; when did they become so proficient in mechanical techniques, to have nurtured such an outstanding young cultivator?"
"If he continues this way, the child is bound to achieve great things!"
Chen Cha looked at Ning Zhuo with new respect, intensely curious, and couldn't help but ask a few more questions. Ning Zhuo replied, "This year’s major exam marked my departure from school life. Elder, you are truly insightful. I indeed have a passion for mechanical arts and have always been interested in it. I try to collect books and study privately, unrelated to the Ning family's school."
Stroking his beard, Chen Cha intentionally asked, "In the hundred arts of cultivation, the top four arts are alchemy, artifact crafting, talisman making, and formation setting. Mechanical techniques are considered the least prestigious within these arts, a niche within a niche. Why do you favor this path?"
Ning Zhuo's heart stirred, realizing this conversation had reached a critical moment. His encounter with Chen Cha was premeditated, including the introduction of the mechanical monkey, which was part of his plan. After a moment of consideration, his expression grew serious, and he solemnly said, "In my opinion, the so-called cultivation is about practicing the truths of the universe. The hundred arts of cultivation are merely applications of these truths, essentially tools."
"Pills are tools, as are magical artifacts and flying swords; talismans and formations are also tools."
"Using these tools can facilitate our cultivation and increase the success rate of various actions."
"The epitome of tools is none other than mechanical techniques!"
"A new material in a mechanism is crafted using alchemical methods. The structure of the mechanism is shaped using artifact-crafting techniques. The formations and talismans on a mechanism involve the skills of setting formations and making talismans."
"An excellent mechanical creation is a clever combination of cultivation techniques."
Pausing, Ning Zhuo added, "The reason why mechanical techniques are considered the least prestigious and a niche within the arts is that they are hard to master and have the highest threshold!"
"On one hand, constructing mechanical devices requires cultivators to master various cultivation techniques. Alchemy, artifact crafting, talisman making, and formation setting are all fundamental. After mastering these, one must choose and combine from numerous complex materials and techniques."
"On the other hand, designing mechanical devices is even more challenging. It tests a cultivator's thinking, talent, inspiration, and imagination. A good design might take a cultivator over a decade to complete, often getting stuck at one point for many years."
"Only an excellent design can lead to an excellent mechanical creation."
Upon hearing Ning Zhuo's exposition, Chen Cha leaned back slightly, his eyes glowing as he scrutinized the young man before him and couldn't help but clap, "Well said, well said!"
His attitude towards Ning Zhuo changed again.
From initial appreciation and interest, he now felt a kinship with a fellow practitioner.
Human interactions are fascinating. Some people live together day after day, yet remain the most familiar strangers. Others may resonate and agree on principles even in their first meeting.
As Chen Cha and Ning Zhuo talked more, their rapport naturally changed their forms of address. Chen Cha affectionately began calling Ning Zhuo "Little Zhuo," while Ning Zhuo started referring to him as "Old Chen."
In response to Ning Zhuo's questions, Chen Cha pondered for a moment and presented three schemes.
Normally, he would have offered just one for clarification. But facing Ning Zhuo, he held nothing back.
Ning Zhuo listened to the three schemes and immediately raised countless questions, each one inquired about.
Chen Cha answered all of them, his demeanor extremely enthusiastic, casting aside any thoughts of charging a fee.
Ning Zhuo continued to give feedback, suggesting modifications to the three schemes.
Chen Cha became engrossed in the discussion with a fellow enthusiast, finding great joy in the process.
During their discussion, the plans were rapidly refined and optimized, eventually settling on adding blood to the fiery monkey, arranging dynamic formations within the blood to stabilize the body while the blood's evaporation helped dissipate heat, significantly alleviating the heat the fiery monkey had to endure.
Chen Cha concluded, "Based on my many years of experience, once the fiery monkey is released, it will definitely be very popular."
"Little Zhuo, why don't you have my Flying Disc Workshop produce the fiery monkeys?"
"For you, how could you produce a large number of mechanical fiery monkeys on your own?
"You'd need to entrust a workshop for mass production."
"My Flying Disc Workshop has enough cultivators and equipment to meet your manufacturing needs."
"Moreover, I have been operating in Huoshi Immortal City for decades, with ample sales channels and some backing from the city lord's office."
"On one hand, I can rely on connections to achieve a degree of tax relief, letting you earn more."
"On the other hand, this also serves as protection. Once the mechanical fiery monkeys are released, they will severely harm the interests of the Monkey Head Gang."
"This gang raises spirit monkeys, and their biggest business is commanding the monkeys to pick the highly explosive fire persimmons."
"This point needs to be anticipated in advance," said Ning Zhuo, blinking as he feigned hesitation.
Chen Cha smiled genuinely and earnestly reassured him, "Little Zhuo, let me be honest with you."
"This is also greatly beneficial for me."
"My Flying Disc Workshop has not had a standout product for many years. Your fiery monkey perfectly meets my urgent need."
"The better the fiery monkey sells, the brighter the reputation of my workshop will be, and the easier business will become."
"Therefore, I will only take thirty percent of the fiery monkey's profits. All the production costs will be completely borne by me!"
Ning Zhuo scratched his head, "Old Chen, I can feel your sincerity, but..."
Chen Cha stroked his beard, "No worries, such a big decision indeed needs careful consideration. Perhaps, Little Zhuo, you should consult your family. However, although the Ning family is a great cultivator clan, they don’t have much strength in the mechanical field. Relying on the family for this business is not ideal. In fact, they might also be entrusting the work to a mechanical workshop."
"Old man speaks truthfully, you can go and investigate!"
Ning Zhuo waved his hand, "Old Chen, I have been orphaned since childhood, living with my great uncle and aunt. Now that I have graduated from the academy, I have completely left and am living independently."
"I can make these decisions on my own. I have never considered handing over the mechanical fiery monkey to the control of the Ning family."
"I only have a small request."
Chen Cha replied, "Oh? Go ahead, don't hesitate."
Ning Zhuo said, "I would like to join your workshop and participate in the various activities of the mechanical workshop to help me gain experience. I also want to learn more from you, Old Chen. I have many questions that have accumulated. As for the consultation fee, it could be deducted from my profits from the fiery monkey, how about that?"
Chen Cha laughed heartily, "Little Zhuo, having you here is a blessing for the Flying Disc Workshop. I warmly welcome you!"
"With your talent, why not just become the deputy workshop master?"
Ning Zhuo hastily waved his hands, "That won't do! I am inexperienced and need to learn and seek guidance. I am just an ordinary Ning family youth, how could I possibly serve as the deputy workshop master?"
"Ordinary? You are far too modest!" Chen Cha shook his head, sighing deeply, mistakenly thinking it was the grand family tradition of the Ning family.
Inside, Ning Zhuo thought, "Old Chen praises me and treats me so well probably because he sees the potential for business and profits from mechanical arts."
"I have only had minor successes in mechanical techniques, whether it’s the up-down lucky rope or the fiery monkey, there's a great distance between them and the classic mechanical creations."
"Take designing the mechanical monkey, for example; it took me several years and many trials and errors. This time's difficulty was resolved only after consulting Old Chen."
"In mechanical arts, I still need much more significant improvement."
"Old Chen's praise should not be taken seriously; I truly do not deserve such high regard!"
Unbeknownst to him, Chen Cha's praises were never exaggerated and were firmly rooted in reality and his rich life experiences.
Ning Zhuo did not realize that these were Chen Cha's genuine thoughts. On one hand, Ning Zhuo had always hidden his talents well, never having such a fellow practitioner interaction before and not knowing his true standing.
On the other hand, following his mother's dying wish, he had always been cautious and restrained, always mentally preparing himself to hide his abilities.
Even when he achieved some success, he would find ways to critique himself from various angles, pointing out every flaw to ensure he never became arrogant or complacent.
For fourteen years, he continually reminded himself: "I am ordinary, just like everyone else. Even if I succeed, others can do the same. I must keep striving and never slacken..."
Over time, countless reassurances formed a very humble character, unable to see his own excellence, and truly believing he had much more to improve on.
That night, Ning Zhuo placed the motion-array-equipped fiery monkey back into the furnace for another baking test.
"This time, it is likely to succeed."
Ning Zhuo was quite confident in this.
"All thanks to Chen Cha. His experience is not just ten times mine, but at least a hundred times more."
"In the future, working in his mechanical workshop, I must make good use of this opportunity to learn as much as possible from him."
Ning Zhuo had been studying Chen Cha for years and understood much about the latter's character.
Just as Chen Cha held Ning Zhuo in high regard, Ning Zhuo also had a high opinion of Chen Cha.
"If there are no issues with the fiery monkey in this key phase, the next step will be how to reach the Magma Immortal Palace."
The Magma Immortal Palace was hidden within the body of Huoshi Mountain, concealed in thick magma.
Ning Zhuo first needed to reach the interior of Huoshi Mountain.
There was a path for that. First, reach the summit of Huoshi Mountain, start from the volcanic vent, and enter the Red Flame Demon Melt Cave. From among thousands of passages, choose the correct path, then keep going deeper, and he would be able to see the Magma Immortal Palace.
"But if I delve into the cave for the first time and the Magma Immortal Palace encounters problems, it would be too conspicuous."
"After all, for so many years, I had never entered the Red Flame Demon Melt Cave before. Suddenly entering the cave would be abrupt."
Thinking of this, Ning Zhuo immediately thought of his great uncle Ning Ze, who could potentially provide him with the perfect cover for his operations. This sparked an idea in his mind, and he began to formulate a plan.
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2024.04.22 18:16 Afoolfortheeons Tales of the Phoenix - Part 12: Exposure

Waking up to the sounds of footsteps in your camp is always alarming, but what's worse is when you actually get up to confront the mysterious invader of your space, weapon in hand, only to find there's no one actually there.
That's how I woke up yesterday, with my mind three sails to the wind from both the ingestion of twenty-six of those devilish white pills and the tantalizing effects that they had on me. If you've never taken DXM before, it is really a trip. Has a multitude of different effects on different doses, which are sorted into various plateaus of experience. We were soaring in the third plateau, where there was a grand expanse of visions that stretched in front of our eyes when opened or closed.
The thing with DXM is that you can get lost on a phantasmic joyride of the senses when you close your eyes and meditate on the masterful, vivid hallucinations that materialize in that dark space behind your eyelids. You'll just be flying through a complex, confusing landscape, a classroom of sorts in which God plants ideas in your head that you haven't had in a thousand lifetimes, you'll forget that you just took something a couple hours prior. And then, you'll be game for whatever show the daemons of your mind tempt you with witnessing and exploring for what seems like hours, but in reality, might just be minutes.
As you remember things you thought you once knew, you'll jam out to the music that you're consciously creating just below the surface; powerful, yet not capable of breaking through the barrier of the mind to become full-fledged auditory hallucinations. Likewise, you won't “feel” yourself moving, but as you traverse the ever-evolving world that has been called up in front of you, you'll believe you are there, with all the dancing elves that take all forms to trick what's left of your mind into believing you're just along for the journey as you're carried through your own dreams that speak of things to come.
It's difficult to properly formulate the words to describe the myriad of madness crawling before your peepholes on this drug, so I'm not going to do you a disservice by attempting to wordsmith something Michaelangelo might conjure with his paintbrush. Instead, I'll just tell you straight up: I went to hell on this trip. Now, I've been to hell before on DXM, some ten to twelve years ago. I was shown visions of all that awaited me if I did not change my ways. And, because I followed through with the will of God to return to the path He set forth for me, my revisit to the fiery pits full of flesh horrors not fit for this world, I must say, I was not afraid.
See, Byoomth in all his spook spookiness had seeded this trip by giving an unusual request after we downed the chalky pills: he asked me to take out Peppermint. If you are not familiar with my story, Peppermint is a pink penguin plushie who I acquired early on in my homeless odyssey and she has helped my mental health immeasurably. In recent times, I've mostly kept her safe and clean in my backpack, but having her out on this night made me feel vulnerable. Yet, I must state that this did not make me feel weak. I was just open and accepting of the waves that came crashing on my shore.
There was a moment we had where I realized all was good, and I had nothing to fear, for I had God on my side. After Byoomth returned from his personal side quest which required him to shuffle off to some corner of the mountain to be alone, I got to express something dear to him. As he lay there on his dirty mattress, eyes appearing larger than normal, almost cartoonish in their orbishness, I pulled out Peppermint from underneath me, as I had rolled on top of her during the mayhem of the night, and I began speaking.
“This…is Peppermint…she's my pen…” I paused, unsure of where to take the word in my drug-induced daze. However, Byoomth cut me off with some of his own druggy verbiage. I don't remember exactly what he said, as I was lost in the throes of my mental battle. I felt exposed, like I almost let out a great secret that would compromise everything I stood for. But, what was it? I couldn't think. I was drifting in the dextromethorphan dimension of dubious, delirious dialogue. There were no words for the mystery that was ravaging my mind. Whatever it was, I was at a loss to bring it to the forefront of my mind, so I could examine it with more than my subconscious.
Megathread
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