I'm looking for an appropriate outlet for my manuscript-in-progress, and currently deciding between four journals to target. I've never submitted to a journal on my own before (always the et al...) so I want to make sure I'm interpreting the scope/aims of the journals correctly and making a good decision, especially because it is a small scale study. My advisors recommended I just email the editors and ask if my project would be of interest or a good potential fit for the journal so I don't waste my time submitting when it will be desk rejected for being out of scope, but I'm not sure what this email should look like or what the proper etiquette is. I wrote up something like this but it feels really long. It's like 400 words.
Dear Dr. Lastname,
I'm a PhD student from University currently searching for an appropriate journal for my research on Topic. I was wondering if you could provide some guidance on whether my manuscript would be suited for submission to Journal.
I investigated... (brief description of research questions and method, in about 100 words)
I learned that... (brief description of major findings, in about 100 words)
(Briefly explain how my small study could be of interest to a broader audience + my concerns / questions about how it fits into the journal scope) I would greatly appreciate your guidance on whether this manuscript is a good fit for Journal.
Sincerely,
Rhinestone Star
Any feedback is appreciated!

Hi all, I’m trying to deepen my knowledge about how municipalities are currently implementing circle economy solutions, and what they could implement. I’m especially interested in solutions that make financial advantage for the locals, and also makes the area more resource resilient. I’m currently in the research phase, so please suggest any source that is even just a bit related to that topic or leave a comment with your personal experience/opinion/ideas.
Thanks in advance!

A little background about me: I started learning Python on and off 3 years ago. Eventually, I got an unpaid internship and a mentor to work on a game engine written in C++. Since then, I have been learning C++. I come from a nontraditional background. I do not have a CS degree. Recently, my internship moved away from C++ and is now using Rust.
I have a big problem when I am building a project. I tend to spend too much time reading about different concepts and very little coding gets done. Say for instance I want to create a window in C++. I would google and look at technical documents. However, in my research, I get lost in a rabbit hole and it is difficult for me to get out. At the end of it all, I have not written any code but my brain is exhausted from reading. How can I balance this? I know I need to read when I do not have the technical knowledge about a topic, but how do I limit my time researching when the problem is unknown and I do not know if what I am researching is useful?
I want to be able to build large projects iteratively and master execution. Planning is a no-brainer, but what can I do to stop myself from overplanning? What are some tips I can use to extract useful information quickly? How can I improve my mental processing speed? Would learning about software architecture help me execute projects? I feel like I am walking in the dark most of the time because almost everything is new to me. I would like to hear how you guys build your projects as well. What are some habits that have helped you build your projects?

Hi again!
I asked for some help here a while ago about my chemistry research paper (4000 word count). The topic is extraction/purification of natural dyes and then comparing their properties.
I discussed with my supervisor about using curcumin (which you guys helped me come up with it, so thank you!). He has said that was possible, but he also suggested maybe using lichen, which is apparently what litmus paper is made of.
He said I could collect it from somewhere nearby, extract it at different concentrations, and compare it. Since it is pH sensitive, he said I could look at it at different pH solutions and use spectrometry to compare its sensitivity. I feel like this is an interesting idea, but he said there wasn’t many sources on it.
Do you think I should use litmus or curcumin? If I were to look at curcumin, I am not exactly sure what I could compare (as it is not as pH sensitive).
Also, doing the lichen experiment, what would my first steps be? Obviously I would extract the dye at different concentrations, and then use different pH solutions to characterize it? My supervisor suggested that, but I don’t really understand… How would I ”characterize” it?
Also how exactly does spectrometry help me measure its sensiitivity? Would I compare it before and after using a pH solution?
I know this is a lot, so I am very sorry. I am in need of help and I didn’t know where to ask…

This subreddit needs an official questionnaire and I think this one is easy enough to answer. I don't expect to become sure of my type because of internet strangers, but I do like answering questions about myself.
My Enneagram type is either 6w5 or 9w8, 469, sp/so. I have autism. (I think an official questionnaire should ask for this information. Autism can influence E (empathy), F (sensory issues), V (executive dysfunction) and L (special interests). A high self-preservation instinct can look like F (routines, health), sexual and social can look like F too (wanting to look attractive or socially acceptable (or maybe like you belong to a subculture). A low sexual or social instinct could look like lower E.)
L (logic)

• How much time and energy do you spend researching or studying? Do you like researching and studying, and why?

I enjoy studying, but every time I decide I should do it more I make a plan of everything I want to study and then it starts feeling very heavy. I want to only study fun topics like typology, psychology, philosophy and languages. I do it for fun and because I feel inferior when I have less knowledge than other people.

• How many of your own opinions do you form? How often do you do actual thinking on your own, more than just finding an existing answer?

I have some core beliefs that help me form opinions on different topics (for example the theory of evolution, which can be applied to most topics). I sometimes form an opinion based on what makes sense for me instead of what is factual. If I don't understand something I can be skeptical, if something I don't believe in (for example astrology) got scientifically proven I would feel very uncomfortable and question the results.

• How often do you talk about concepts or facts? Why exactly do you talk about it, and what do you like talking about most?

I like telling people about personality systems. I think teaching people and typing them makes me feel useful, and I need to type people irl if I want to understand the systems. I sometimes talk about philosophy, but that usually doesn't go anywhere because my beliefs are too unromantic for other people and they often judge me for being a nihilist or an egoist. I also like learning and teaching languages, maybe too much. I think some people feel pressured by me trying to teach them.

• Do you struggle with thinking about things by yourself? Does this bother you, and how much? How well do you handle criticism from others when it comes to your logical concepts or factual knowledge?

I often struggle with understanding scientific topics. It does bother me a lot, I am afraid of my future children asking me to explain physics to them. I avoid criticism like the plague, I don't want to express anything that could be false so I often either don't express myself or triple check everything. I easily doubt my own opinion, especially if the topic is a complex one like typology. Philosophy is much simpler, you just state your opinion and then the other persons states theirs and then you both think that the other person is stupid, but this is easy for me to say since my opinion is always the simplest one and therefore correct. ("What is the moral choice her?" "Morality isn't real." "Was this a selfish action?" "All actions are selfish." "What is the meaning of life?" "There is no meaning." "Is god real?" "We don't have any proof that god exists.")

• Did you enjoy answering the above questions? Would you say this is a major part of who you are or your identity? Was it boring? Is it a difficult topic?

Yeah, it was fun. It is a major part of me, but I know that if I had been born into the stone ages it wouldn't be.
E (emotion)

• Do you consider yourself a creative person? What do you do that's creative?

Not really, I sometimes have creative ideas but I rarely do anything with them.

• How do you feel about expressing your own emotions? Are emotions part of your decision-making at all? How much of a role do they play in your decisions?

I am fine with expressing emotions like anger or fun, but I don't want to express deeper or less strong feelings like love. I rarely love people, and I can't express something I don't feel.
Of course they are part of my decision making process, they are for every human. If you choose a path because it feels the most secure you are making a decision based on anxiety, or on wanting to feel more comfort than anxiety in the future. I sometimes base my decisions on excitement. I don't want to have a boring job.

• How much effort do you put into creating a positive emotional influence on other people? Do you try to do this at all? Do you like exploring the emotions or creativity of others?

I try my best to not create a negative one, and I try to make people feel better about themselves when they are insecure about something. I am not very interested in talking about the feelings of my friends, but I do play therapist sometimes because of my interest in psychology. I am interested in creativity in general, I enjoy listening to music and making and sharing playlists, but I am usually not deeply interested in my friends.

• Do you feel uncomfortable with the idea of sharing your emotions? Do you struggle with knowing exactly how to connect with others on a deeper and more emotional level? Do you struggle with knowing how to go about dealing with and handling your emotions?

Yes, it makes me feel either vulnerable (if I have strong emotions) or inhuman (if I don't have enough). Yes, I don't do it much. The thought makes me uncomfortable. Yes, but ONLY because I'm very sensitive and quickly cry, which can be very inconvenient and I don't know how to stop it.

• Did you enjoy answering the above questions? Would you say this is a major part of who you are or your identity? Was it boring? Is it a difficult topic?

Yes. Not really, but I have been thinking about morality more so maybe in the future, although that might be more of a Volition topic.
F (physics / foundation)

• How much time and energy do you put into your physical health? Do you try new healthcare or self-care products often? How often, and what kinds of products do you like trying?

Sleeping and not being hungry are important to me, but apart from that I don't do much. I don't care about what I eat or where I sleep as long as it's enough. I don't often try new products, if I do it's either because I noticed a problem (which can take a long time) or because my mother (3F) noticed one.

• How much do you care about your physical appearance, including fashion choices, or decorating the physical environment for comfort? Do you like exploring the physical environment (food, nature, architecture, etc), or doing physical activity?

I think I used to care about it for a while, but then I either forgot about it or decided that it is a waste of money and time. I still have preferences, I just try to not spend too much energy on them. I enjoy nature and some sports, but I sometimes forget about them for a while. I sadly don't get much pleasure from eating or looking at things.

• Do you like talking about your personal tastes often? How often do you explore the personal tastes of others? What about your own health or the health of others? Do you like creating or exploring comfortable environments with others?

Yes, but the tastes I talk about are my taste in music or movies. I don't like hearing about other people's tastes as much because I feel like I then have to spend time listening to their favorite artists, and then I have to form an opinion on it... and I don't like most artists.
Idk about the other questions.

• Do you stress about what people will think regarding your personal tastes? Do you prefer to follow fashion trends in worry that people may judge your own style? Do you worry about being sick or in poor physical health often? Are you able to take criticism about your health, aesthetic choices, personal tastes, or physical appearance?

No. No. Sometimes I think that I'm sick, but it doesn't make me panic. Not sure, I think I sometimes ignore it and sometimes follow it, it probably depends on how much effort changing it would take. My mother is 3F and I think her criticisms are annoying, she wants me to change my knife holding habits and stop eating old cooked rice (I hate wasting food). But I can critique other people, for example for not being clean or practical enough.

• Did you enjoy answering the above questions? Would you say this is a major part of who you are or your identity? Was it boring? Is it a difficult topic?

Not really, it wasn't difficult, just a bit boring. It's not important to me, except my fashion choices since they usually reflect my identity.
V (volition)

• Do you know how to get what you want? How much effort do you put into figuring out how to get what you want? Do you just take action and get started, do you plan, do you research or try to get advice from others?

Yes, but only in the physical world, I can for example get people to watch my favorite movie.
I make detailed plans that are too ambitious for me to follow. I like having a detailed plan, it makes me feel like I can achieve my goals. If I'm panicking about a goal I make a detailed plan. But I usually don't follow the plan because I have low energy/ problems motivating myself. I take advice from others if they are more knowledgable than me and probably from my mother.

• How often do you feel motivated to work on your future? How often are you busy working on a goal for the future? Do you prefer routine, or often fall into routine? Is your routine making progress on a goal? What makes you change your routine? What makes you start working on a goal?

Sometimes I get the feeling that I need to get my life together and then I make a bunch of plans and lists, but I don't work on them enough. I procrastinate a lot. I'm bad at routines, I prefer making a to do list every day. I sometimes try establishing a routine to reach a goal, but then I forget to follow it or am unable to follow it exactly because I can't predict how long a task will take or because something gets in the way. I either start working on a goal when I'm motivated or when I'm panicking.

• Do you like guiding or helping people reach their goals? What kinds of goals do you prefer to help people with? Are you a leader, or do you prefer to work in groups where you're an equal? How and when do you take charge, if ever?

Yes, it makes me feel useful. I always try to make people feel like they can reach their goals, but I can also be critical, especially about job choices. I sometimes get the urge to make language study plans for people.
I prefer working in groups of people I know well, if I'm with strangers I'm too shy to speak up. I take charge in small groups of incompetent people, I can remind people of their responsibilities, but I don't want to make decisions on my own. I can also take charge when it comes to physical needs like food (but I will ask everyone their preferences).

• Do you overwork yourself? Do you worry that you might be lazy or that you aren't progressing quickly enough? Does it feel impossible to find the right method forward? Are you able to take criticism over your choices for working towards your goals? How do you respond to being challenged?

No, I am too easily stressed. I don't worry about being lazy, I know that it's true. I do feel a lot of shame and anxiety about my productivity, but I think anyone who is as lazy as me would.
I worry about missing something. Do I really want this future? Isn't there something better out there? I've changed my mind about my future in the past and wasted a lot of time that way, so now I want to make sure, but that's impossible. Finding the right method is important too. It does feel impossible but that's because it IS, noone can really know the future except maybe a super-super-computer.
I think I can take criticism, but I might cry or consider murder before accepting it, especially if it includes a character judgement (I've heard "You're too sensitive for this job. You should try [similar job] instead." Who do you think you are to give me advice? You don't know my reasons for choosing this job.). Except if the criticism is not valid, then I can ignore it.

• Did you enjoy answering the above questions? Would you say this is a major part of who you are or your identity? Was it boring? Is it a difficult topic?

More difficult than boring, it's difficult for me to separate Volition from the other aspects. I used to not have any goals, but now it is a part of my identity, but I know that my goals might change.

Impact-Site-Verification: 0080656a-6495-4f92-b6a8-13919ad063be
CBD, short for cannabidiol, seems to be everywhere these days, from wellness shops to your neighbor's medicine cabinet. But what exactly is it, and why is everyone talking about it? Let's dive into the basics of CBD:
1. What is CBD? CBD is a compound found in the cannabis plant. Unlike its cousin THC (tetrahydrocannabinol), CBD doesn't get you high. Instead, it's renowned for its potential therapeutic benefits without the psychoactive effects.
2. How does it work? CBD interacts with the body's endocannabinoid system, a complex network of receptors that regulate various bodily functions like mood, sleep, appetite, and pain. By influencing this system, CBD may help maintain balance and promote overall wellness.
3. What are the benefits? While research is still ongoing, CBD has shown promise in managing various conditions, including anxiety, insomnia, chronic pain, epilepsy, and even acne. Many users also report improved relaxation and stress relief.
4. How to use CBD? CBD comes in various forms, including oils, tinctures, capsules, edibles, topicals, and vapes. The best method for you depends on your preferences and desired effects. Start with a low dose and gradually increase until you find what works for you.
5. Is it legal? The legal status of CBD varies by location. In the United States, CBD derived from hemp (containing less than 0.3% THC) was federally legalized in 2018 with the Farm Bill. However, it's essential to check your local laws before purchasing or using CBD products.
6. Quality matters. Not all CBD products are created equal. Look for reputable brands that provide third-party lab test results to ensure purity and potency. Avoid products with dubious claims or unrealistic promises.
7. Consult a professional. If you're considering using CBD for medical purposes or have underlying health conditions, it's wise to consult with a healthcare professional first. They can offer personalized advice and help you navigate any potential interactions with medications.
In conclusion, CBD holds significant promise as a natural remedy for various ailments, but it's essential to educate yourself and approach it mindfully. Whether you're a newcomer or a seasoned user, feel free to share your experiences, questions, and insights below. Let's keep the conversation going!

• 🧮 Complex Math: Algebra, Calculus, Geometry, and Statistics.
• 💻 Coding: Algorithms, Data Structures, Python, Java, and more.
• 🎨 3D Modeling: Blender, Autodesk Maya, Unity, and Unreal Engine.
• 📝 Essays: Writing assistance for various subjects.
• 🔬 Bio & Chem: Biology and Chemistry topics covered.
• 📚 History: Historical research and writing support.

Specializing in a wide range of topics to help you excel in your academic pursuits. Reach out for personalized support today! Email; qwriters27@gmail.com discord; dr.nicho

Bank of America Health Care Conference 2024 Presentation
Exact Sciences' Mission is to help eradicate cancer by preventing it, detecting it earlier and guiding treatment. In the early innings of how genomics will transform cancer prevention, diagnosis and treatment
Exact Sciences' Cologuard and Oncotype DX are two of the top brands ever in cancer diagnostics. They are helping to build a platform company through which other innovative cancer diagnostics will help patients.
Guided to 15% growth (CAGR) through 2027. Projecting over 20% adjusted ebitda margins by 2027.
Near-term growth drivers - Cologuard and Oncotype DX globally. Future drivers - pipeline.
Reiterated 2024 Revenue and EBITDA guide.
60 million Americans not up to date with colon cancer screening - huge unscreened population
Q4 2023 - highest dollar growth in screening in history. Sequential decrease in Cologuard screening revenue due to normal Q1 seasonal weakness. Despite sequential screening revenue decline, screening revenue still increased 7% YOY, and management confident in achieving 2nd Quarter and 2nd Half Guide revenue guides.
Cologuard will have steady predictable growth based upon # of sales calls to primary care physicians and increasing Health System Orders.
New Cologuard business opportunity starting last year - screening in Medicare Advantage population and gap closure programs in large health systems.
CEO Kevin Conroy: "We are confident in our ability to meet our 2nd quarter and 2nd half sales guidance."
Q1 2024 was in-line with expectations. Q1 of 2023 was an anomaly.
Sales and Marketing Spend - Spent about $800 million in sales and marketing in 2023 (sales force a relatively small component of this, sales force being brought back to levels of 2022) - High ROI from investment in additional sales people.
Last 5 quarters added 50,000 new primary care providers - docs, pa’s and nurses
As docs order more, amount of orders increases. As sales calls increase in frequency, pcp’s order more.
Calling on a doc once per quarter will result on average in six orders. Calling on a doc six times per quarter will result on average in 24 order. Sales reps provide pcp's tools, education, motivation to increase colon cancer screening numbers.
Priorities for CFO - Maintain Growth Engine not only of CG and Oncotype, but also new product pipeline - Flywheel of innovation needs to keep spinning. Will expand over 300 basis points of leverage in 2024. Increasing leverage in G&A going forward. Clear and credible pathway to adjusted ebitda margins of 20% in 2027
CFO Aaron Bloomer: Exact Sciences will show FCF growth and positive FCF delivery for each of the next three quarters in 2024.
17% CG growth embedded in 15% CAGR through 2027. (Compound Annual Growth Rate)
Impressive CAGR over the past few years. Seeing increasing opportunities to enhance the use of Cologuard as a frontline screening tool.
Over a billion dollars invested in EXACT NEXUS - Electronic Ordering, Result Delivery, Prior Authorization, Reimbursement embedded into physician's EPIC electronic record. Huge amount of customer satisfaction - makes using Cologuard easy.
Long arduous process of including Cologuard into the Quality Measures (2-3 years from being included in USPSTF guidelines), which can help health systems and plans increase their star rating in order to get quality bonuses, which is a key to their success.
130,000 new cases/year, 50,000 deaths/year from Colon Cancer, with 60 million people in U.S. not current with CRC screening guidelines.
Colonoscopy capacity in US is 12,000,000. Half screening, half diagnostic. Cologuard is helping health system and GI’s getting more people screened.
Re-screening now mid 20's as a % of revenue - aiming for 50%
Because of Covid, for two years in a row, only 1.2 million people have been eligible for re-screens. This year 1.6 million eligible for re-screen, and that number will increase annually. Also, 20 million new prospective customers in the 45-49 age group - want them to be happy customers for next 30 years. The 45-49 age group rescreens are starting to kick off this year (USPSTF guideline to include that age group updated in 2021).
Cologuard Plus - 10 Years of R&D and Clinical Trials - Improved False Positive Rate, Cancer Detection, Advanced Adenoma Detection. Improvement on all levels, and Cologuard 3.0 already in development.
Looking for a modest price increase for Cologuard Plus rolling in over a couple years period of time. Because false positives are lower - 30% fewer false positives - more people will stay in Cologuard Testing Family
Cologuard Plus also benefits from 5-7% Lower COGs = margin expansion.
20th Anniversary for Oncotype in US. 1 billion cumulative investment in Oncotype infrastructure. Quality of Science and Clinical Evidence behind it is unmatched. Company is deeply rooted in being patient and customer-centric.
Question to Brian Baranick, General Manager of Precision Oncology - How are you gonna catch up in MRD?
With respect to MRD, have never seen such a fast developing market - real clinical unmet need - enthusiasm among patients and physicians - excited to be apart of this market. Exact Sciences will catch up in MRD due to the following:
1) World class commercial capabilities - precision oncology reps are experienced, know physicians/territories, how to sell and how to get access to leverage these relationships to launch CRC MRD next year.
2) Exact Sciences' Nexus Platform - IT infrastructure to help providers save time obtaining prior use authorizations. This billion dollar company investment will allow providers to obtain prior use authorizations and order MRD tests more quickly and easily.
3) Better Performing Product - Partnering with West German Study Group and NSABP (National Surgical Adjuvant Breast and Bower Project) To build out evidence around MRD tests - Goal is for Exact Sciences' MRD tests to have best in Class Evidence. Exact Sciences' MRD tests measure more mutations in blood than some of the first mover companies in space, and will have best in class evidence. Investors will hear more about performance of MRD assays and evidence in the back half of this year.
Blood-based screening assets - crowded marketplace - Use case for Cologuard Blood will be limited.
Great idea in concept - Bert Vogelstein is a pre-eminent researcher in the field and wrote a 2005 paper on the subject of CRC screening blood test. He concluded that detecting circulating tumor dna from precancerous lesions/polyps is impossible - you can’t find what’s not there. According to Kevin Conroy, if you’re not finding pre-cancer, you don’t have a true screening test.
The real power of colon cancer screening is finding and removing pre-cancerous polyps which may result in Stage 1 disease - that is the goal. As a result, it is highly unlikely that blood tests to screen for CRC will end up in the USPSTF guidelines and quality measures b/c they are unable to detect precancer. CRC screening blood test will end up being more of a niche market. Commercial payers will not be too excited to pay for something which is not in the quality measures. Probably won’t find out if blood CRC screening will be in the quality measures until 2028-29 (After likely USPSTF in 2027). Howver, fee for service medicare advantage has agreed to pay for blood based crc. USPSTF meets every 5-8 years on CRC screening (August, 2014 - May, 2021). Predict next Meeting in 2027. This cycle think 6 years until USPSTF and then quality measures 2-3 years later
Management expects two or three blood tests to be approved by the FDA, including Cologuard Blood. Don't believe blood tests will ultimately be a big overhand for investors as Cologuard will still grow market share even with other FDA approved CRC blood tests as it is the most effective CRC screening test. GI societies recently weighed in - not recommending blood tests for frontline CRC screening. The growth of Cologuard over the coming years will be what excites investors, not CRC blood test.
Question to CFO Aaron Bloomer: What is most underappreciated or misunderstood about the company?
CFO is excited about pipeline. The company has spent many years developing these pipeline products, a number or which are slated to launch over the next few years. Don’t think investors appreciate the impact these pipeline products will have on patients, on revenue and the Company's growth profile, as well as on margins.
Excited about mid-teens growth in Cologuard and along with MRD and other new products coming online in the next few years which will provide both the Company with both leverage and diversification.

DAY: MAY 15, 2024

• 5-15-2024ALZHEIMER’S DISEASE PROCESSES WITHOUT SYMPTOMS. HOW IS THAT POSSIBLE? Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process. Some individuals reach the age of 90 or even 100 in good health, without medications or brain disease. But how do these individuals maintain their health as they age?
• 5-15-2024COULD A LOW-CAL KETO DIET HELP EASE ACNE? In a small pilot study, some young women looking to lose weight on a low-calorie keto diet got an unexpected benefit: Their acne began to clear up. “These findings represent an opportunity to control a skin disease that affects most teenagers and many adults at some point in their lifetimes, causing distress, embarrassment, anxiety and low self-confidence among sufferers, robbing them of their quality of life,
• 5-15-2024FIGHTING FAT AND INFLAMMATION: SCIENTISTS DEVELOP NEW COMPOUNDS The menthyl esters of valine (MV) and isoleucine (MI) are multi-faceted molecules with enhanced anti-inflammatory and anti-obesity activities. The discovery and development of such molecules can result in newer classes of therapeutic drugs to treat a wide range of metabolic disorders. Credit: Gen-ichiro Arimura from Tokyo University of Science Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times. Menthol is a naturally occurring cyclic monoterpene alcohol found in various plants,
• 5-15-2024TREATMENT OPTIONS INCLUDE ALTERNATIVES TO CHEMOTHERAPY, EXPERT EXPLAINS Chemotherapy is usually the first treatment doctors try to treat lymphoma, including the two most common forms: non-Hodgkin and Hodgkin. But alternatives to chemotherapy are developing, as first-line treatments and as backup options, explains Stephen Ansell, M.D., Ph.D., hematology chair and hematologic oncologist at the Mayo Clinic Comprehensive Cancer Center. Lymphoma is a blood cancer that begins when a germ-fighting white blood cell, called a lymphocyte, mutates and rapidly multiplies
• 5-15-2024CHECKING YOUR BELLY BUTTON CAN TELL YOU A LOT ABOUT YOUR HEALTH Navels, belly buttons, innies or outies … whatever term you use, your umbilicus may have plenty to tell you about the state of your health. For some, they are the thing of nightmares—omphalophobia (the fear of belly buttons) is a real condition. For others, they are a fashion accessory to be shown off in a crop top, or decorated with a body piercing. Whatever your feelings about belly buttons, one thing’s for sure—it once joined you to your mother
• 5-15-2024STUDY FINDS H5N1 VIRUS FROM 2022 MINK OUTBREAK CAPABLE OF INEFFICIENT AIRBORNE TRANSMISSION Direct contact transmission, weight loss, and survival for ferrets infected with A/mink (H5N1). Four donor ferrets were inoculated with A/mink (H5N1) and 24?h later each donor was paired with a contact in the same cage. Nasal wash samples were collected every other day for 13 days, and weight loss and clinical signs were monitored. A, B display viral titers from donor and direct contacts,
• 5-15-2024STUDY SHOWS COMBINING JOYFUL ACTIVITIES WITH ‘SAVORING’ THERAPY SHOWS POSITIVE MENTAL HEALTH RESULTS AMONG YOUNG PEOPLE With rates of depression rising among young people on university campuses, a team of SMU researchers found that combining two different therapeutic approaches demonstrated effectiveness in improving students’ overall mental health. Their findings show that students receiving behavioral activation (BA) therapy augmented with savoring (S) experienced improvements in positive and negative mood. Behavioral activation is a therapeutic approach that alleviates depression by increasing engagement in meaningful activities,
• 5-15-2024AI-BASED SURGICAL PREDICTION MODELS HAVE LIMITS Prediction models generated by machine learning are being increasingly used in medicine to identify risk factors and possible outcomes, especially for total joint replacements of knees and hips—although researchers warn that machine-generated predictions are currently being drawn from a limited data pool. “Machine learning has great potential for processing ‘big data’ and has proved its undeniable capability, although it is not free of issues,
• 5-15-2024STUDY FINDS FRONT-OF-PACKAGE NUTRITION LABELING RESULTS IN HEALTHIER PRODUCTS A study finds that a food labeling system introduced by the French government in 2017 resulted in healthier products. The study of Nutri-Score, a voluntary labeling system that assigns a simple letter grade based on nutrition, is believed to be the first to examine how food manufacturers responded to the change. Using detailed product and nutrition data from 2014 to 2021,
• 5-15-2024EXPERT EXPLAINS PUBLIC HEALTH CONCERNS ON AVIAN FLU Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading into drug eruption. This implies that HLA is involved in previously unknown signaling pathways and processes that go beyond its traditionally accepted role within the immune system.
• 5-15-2024EXPLORING THE MECHANISM BEHIND DRUG ERUPTIONS IN THE SKINUsing genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading into drug eruption.
• 5-15-2024STUDY PROVIDES BLUEPRINT FOR HYBRID-VIRTUAL HOME VISIT MODEL TO SUPPORT PATIENTS WHO DO NOT LIVE CLOSE TO A HOSPITAL a team developed and successfully tested a hybrid-virtual home visit model that provides care to veterans who do not live close to a VA health care facility.
• 5-15-2024HOW SCIENCE IS CHANGING THE GAME IN SPORTS Digital twins of athletes allow athletes and coaches to evaluate performance and trial technique changes. It’s an open secret that the countries that win the most medals in the Olympics and Paralympics combine talent and technology. Athletes are preparing for the next three Olympics and Paralympics in Paris in 2024
• 5-15-2024STUDY REVEALS HOW PRACTICE FORMS NEW MEMORY PATHWAYS IN THE BRAIN The effects of optogenetic inhibition on WM task performance. a, The experimental set-up. b, The delayed-association WM task trial types; licking was assessed during the 3?s choice period, with early- and late-delays periods noted. c, Learning progress across eight sessions, measured on the basis of the percentage of correct responses. d, Learning session example
• 5-15-2024A MEDITERRANEAN DIET CAN EASE SYMPTOMS OF STRESS AND ANXIETY, SAYS STUDY It’s no secret that the Mediterranean diet is good for your health. Already recommended to reduce the risks of bowel cancer, heart disease, and dementia, new research shows that the Mediterranean diet can also reduce symptoms of stress and anxiety.
• 5-15-2024ENHANCING PATIENT RESPONSE TO CANCER IMMUNOTHERAPY
• 5-15-2024LONGER SPRINT INTERVALS CAN IMPROVE MUSCLE OXYGEN UTILIZATION COMPARED TO SHORTER INTERVALS
• 5-15-2024NEW EVIDENCE FOR USE OF ANTI-INFLAMMATORY THERAPY FOR PREVENTION OF RECURRENT VASCULAR EVENTS IN STROKE
• 5-15-2024STUDY PAVES THE WAY FOR AN ACTIVE AGENT AGAINST HEPATITIS E
• 5-15-2024RESEARCHERS DEVELOP METHOD TO MONITOR PATIENTS WITH SPINAL MUSCULAR ATROPHY USING SOUND WAVES
• 5-15-2024INFERTILITY TREATMENT FOUND TO DOUBLE THE RISK OF POSTPARTUM HEART DISEASE
• 5-15-2024A PROMISING APPROACH TO INTRAOPERATIVE CANCER DIAGNOSIS
• 5-15-2024HOW ROGUE NEUTROPHILS HELP LUNG CANCER SPREAD
• 5-15-2024WOMEN PHYSICIANS ARE UNDERREPRESENTED AND FEEL LESS IMPACTFUL IN CANCER TREATMENT PLANNING VIRTUAL MEETINGS
• 5-15-2024ONLY 20% OF U.S. NONPROFIT HOSPITALS INVESTED IN HOUSING AS PART OF THE FEDERAL COMMUNITY BENEFIT MANDATE
• 5-15-2024NEW STUDY LINKS AUTISM SPECTRUM DISORDER TO DISRUPTED DEVELOPMENTAL DOPAMINE
• 5-15-2024STUDY FINDS SEVERE ISCHEMIC STROKES ARE RARE IN PATIENT POPULATION
• 5-15-2024CYCLIN D1 EXPRESSION MAY BE A BIOMARKER FOR PENILE CANCER
• 5-15-2024GUIDELINE ISSUED FOR PEOPLE WITH EPILEPSY WHO MAY BECOME PREGNANT
• 5-15-2024NEW CARDIAC RESEARCH COULD SAVE WOMEN’S LIVES BY IMPROVING DETECTION OF HEART FAILURE
• 5-15-2024PATIENTS REPORT SIGNIFICANT SYMPTOM REDUCTION WITHIN A SINGLE INTEGRATIVE MEDICINE ENCOUNTER
• 5-15-2024STUDY LINKS PROTEIN SECRETED BY BLOOD VESSELS TO DRUG-RESISTANT CANCER
• 5-15-2024RESEARCHERS EXPLORE THE ROLE OF OF TRANSPOSABLE ELEMENTS IN MYOCARDITIS
• 5-15-2024STUDY REVEALS IMMUNOTHERAPY’S POTENTIAL IN BOOSTING IMMUNE SYSTEMS OF OLDER INDIVIDUALS
• 5-15-2024CANADIAN HOSPITAL DATA SHOW LONGER, COSTLIER STAYS FOR PATIENTS EXPERIENCING HOMELESSNESS
• 5-15-2024SCIENTISTS WANT TO KNOW HOW THE SMELLS OF NATURE BENEFIT OUR HEALTH
• 5-15-2024STUDY FINDS TWO GENES OF THE GERMLINE ARE ESSENTIAL FOR THE DEVELOPMENT OF BRAIN TUMORS IN DROSOPHILA
• 5-15-2024EVALUATING A NEW GROUP TRAINING TOOL FOR THE PREVENTION OF DEMENTIA
• 5-15-2024RESEARCH CHALLENGES LINK BETWEEN MOTOR IMPAIRMENT AND BRAIN INJURY
• 5-15-2024RESEARCH CHALLENGES LINK BETWEEN MOTOR IMPAIRMENT AND BRAIN INJURY
• 5-15-2024CHIROPRACTIC ASSOCIATED WITH LOWER LIKELIHOOD OF TRAMADOL PRESCRIPTION IN ADULTS WITH SCIATICA
• 5-15-2024UNVEILING THE IMPACT OF JOB LOSS ON THE HEALTH OF IMMIGRANTS IN GERMANY
• 5-15-2024HEALTH CARE INTERPRETERS IMPORTANT FOR HEART ATTACK REHABILITATION, SAYS STUDY
• 5-15-2024RESEARCHERS FIND MICROPLASTICS IN CANINE AND HUMAN TESTICULAR TISSUE
• 5-15-2024ANTISEIZURE MEDICATIONS CAN PRODUCE LIFE-THREATENING REACTIONS
• 5-15-2024ADULTS WHO HAD DIFFICULT CHILDHOODS ARE NOT RECEIVING SUFFICIENT MENTAL HEALTH CARE, FINDS CALIFORNIA STUDY
• 5-15-2024AI MAY IMPROVE DOCTOR–PATIENT INTERACTIONS FOR OLDER ADULTS WITH CANCER
• 5-15-2024BLOOD PRESSURE DRUGS MORE THAN DOUBLE BONE-FRACTURE RISK IN NURSING HOME PATIENTS
• 5-15-2024PREVENTING PEDIATRIC FALLS
• 5-15-2024I’M PREGNANT. DO I NEED A MULTIVITAMIN?
• 5-15-2024TREATMENT-RESISTANT DEPRESSION LINKED TO BODY MASS INDEX: STUDY
• 5-15-2024HOW DID THE COVID-19 PANDEMIC AFFECT OLDER ADULTS’ TECHNOLOGY USE?
• 5-15-2024STUDY FINDS LINK BETWEEN BMI TRAJECTORIES AND FRACTURE RISK IN LATE ADULTHOOD
• 5-15-2024STUDY FINDS REDUCED RISK OF BREAST CANCER FOLLOWING BARIATRIC SURGERY IN WOMEN WITH HYPERINSULINEMIA
• 5-15-2024FEWER US OVERDOSE DEATHS WERE REPORTED LAST YEAR, BUT EXPERTS ARE STILL CAUTIOUS
• 5-15-2024PRE- AND POST-SURGICAL IMMUNOTHERAPY IMPROVES OUTCOMES FOR PATIENTS WITH OPERABLE LUNG CANCER, PHASE III STUDY FINDS
• 5-15-2024NEW METHOD USES TAU PROTEIN DEPOSITION PATTERNS TO PREDICT ALZHEIMER’S SEVERITY
• 5-15-2024OLDER NATIVE AMERICANS MAY EXPERIENCE HIGHER LEVELS OF COGNITIVE IMPAIRMENT THAN PREVIOUSLY THOUGHT
• 5-15-2024RESEARCHERS DEVELOP INNOVATIVE PLATFORM FOR MODELING HUMAN MUSCLE DISEASES IN WORMS
• 5-15-2024CLIMATE CHANGE IS LIKELY TO AGGRAVATE BRAIN CONDITIONS, STUDY FINDS
• 5-15-2024NEW STUDY SHOWS CONTINUED HIGH EFFECTIVENESS OF HPV VACCINATION IN ENGLAND
• 5-15-2024FAT-ENLARGED AXILLARY NODES ON MAMMOGRAM MAY INDICATE HIGHER CVD RISK
• 5-15-2024NOVEL INHIBITOR INSIGHTS OFFER PATHWAY TO PREVENTING PXR-ASSOCIATED DRUG RESISTANCE
• 5-15-2024THE DOCTOR IS IN… BUT WHAT’S BEHIND THEM? STUDY REVEALS IMPACTS OF TELEHEALTH BACKGROUND SETTINGS
• 5-15-2024HIGH TELEHEALTH USE TIED TO INCREASED HEALTH CARE UTILIZATION, COST
• 5-15-2024NEW BIOMARKER IDENTIFIED TO DIAGNOSE ALZHEIMER’S IN ASYMPTOMATIC STAGES
• 5-15-2024U.S. DROWNING DEATHS RISING AGAIN AFTER YEARS OF DECLINE
• 5-15-2024STUDY FINDS ASTROCYTIC PH REGULATOR CAN REPAIR BLOOD-BRAIN BARRIER, REVERSE BRAIN DAMAGE CAUSED BY ISCHEMIC STROKE
• 5-15-2024DISPARITIES SEEN IN CARBAPENEM-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTION OUTCOMES
• 5-15-2024WHY IS WHOOPING COUGH SURGING IN THE UK? FALLING VACCINATION RATES MAY BE THE ANSWER
• 5-15-2024CARDIAC REHAB IS A PROVEN BUT UNDERUSED THERAPY IN WOMEN, BUT TAILORED RESOURCES AIM TO CHANGE THAT
• 5-15-2024IRON FUELS IMMUNE CELLS—AND IT COULD MAKE ASTHMA WORSE
• 5-15-2024NEW POSSIBILITIES FOR CELL THERAPIES AND PERSONALIZED MEDICINE
• 5-15-2024HIGHER INCOME REDUCES STROKE MORTALITY RISK BY A THIRD, NEW STUDY SHOWS
• 5-15-2024SOME FORMS OF AUGMENTED BRAIN STIMULATION RECOMMENDED FOR MAJOR DEPRESSION
• 5-15-2024LOW TESTOSTERONE IN MEN ASSOCIATED WITH AN EARLY DEATH
• 5-15-2024WEARING FACE MASKS DID NOT REDUCE RISK OF COVID INFECTION AFTER FIRST OMICRON WAVE, RESEARCH SUGGESTS
• 5-15-2024BLUETOOTH TRACKING DEVICES PROVIDE NEW VIEW INTO CARE HOME QUALITY
• 5-15-2024RACIAL DISPARITIES IN CHILDHOOD OBESITY ON THE RISE IN STUDY OF NYC PUBLIC SCHOOLS
• 5-15-2024TWO DECADES OF STUDIES SUGGEST HEALTH BENEFITS ASSOCIATED WITH PLANT-BASED DIETS, BUT CAUTION URGED
• 5-15-2024TRANSCATHETER VALVE REPLACEMENT OUTCOMES SIMILAR TO SURGERY FOR SEVERE AORTIC STENOSIS
• 5-15-2024RECOGNIZING THE PHYSICAL AND EMOTIONAL TOLL THAT CARING FOR A LOVED ONE WITH A CHRONIC CONDITION HAS ON THE CAREGIVER
• 5-15-2024DIFFICULT WORK ARRANGEMENTS FORCE MANY WOMEN TO STOP BREASTFEEDING EARLY—HERE’S HOW TO PREVENT THIS
• 5-15-2024DAY-LONG WORKSHOP IN COGNITIVE BEHAVIORAL THERAPY FOUND TO EFFECTIVELY REDUCE DEPRESSION IN 16- TO 18-YEAR-OLDS
• 5-15-2024REPORT HIGHLIGHTS BIG GAPS IN CANCER OUTCOMES BASED ON RACE
• 5-15-2024NEW BLOOD TEST COULD HELP SPOT PREECLAMPSIA IN FIRST TRIMESTER
• 5-15-2024HALF-MATCHED FAMILY DONORS OFFER BEST OUTCOMES FOR HISPANIC PATIENTS UNDERGOING BONE MARROW TRANSPLANTS: STUDY
• 5-15-2024SCIENTISTS UNRAVEL GENETIC BASIS FOR NEURODEGENERATIVE DISORDERS THAT AFFECT VISION
• 5-15-2024INCLUDING MORE WOMEN ON HOSPITAL TEAMS YIELDS BETTER SURGERY OUTCOMES, NEW STUDY FINDS
• 5-15-2024RESEARCH SHEDS LIGHT ON HOW PROTEINS LINKED TO ALZHEIMER’S DISEASE INFLUENCE NEURONAL GROWTH
• 5-15-2024RESEARCHERS IDENTIFY NEW MARKER FOR BREAST CANCER PROGNOSIS
• 5-15-2024GETTING OUT AND ABOUT IN THE COMMUNITY MAY BE LINKED TO COGNITIVE FUNCTION
• 5-15-2024NOVEL TECHNIQUE HELPS PREDICT RISK OF A MENISCUS TEAR IN THE KNEE
• 5-15-2024CAN ROBOT-INSPIRED COMPUTER-ASSISTED THERAPY BENEFIT CHILDREN WITH AUTISM?
• 5-15-2024RESEARCH FINDS EXERCISE HAS A SIGNIFICANT IMPACT ON IMMUNE CELLS THAT SUPPORT BRAIN FUNCTION
• 5-15-2024CARDIOVASCULAR DISEASES KILL 10,000 EUROPEANS A DAY: WHO
• 5-15-2024NEW TOOL CAN HELP SURGEONS QUICKLY SEARCH VIDEOS AND CREATE INTERACTIVE FEEDBACK
• 5-15-2024SCIENTISTS DISCOVER BLOOD PROTEINS THAT MAY GIVE CANCER WARNING SEVEN YEARS BEFORE DIAGNOSIS
• 5-15-2024HOW THEY IMPACT LIFESPAN IN VERTEBRATES
• 5-15-2024UN AGENCY AUTHORIZES SECOND VACCINE AGAINST DENGUE AMID OUTBREAKS IN THE AMERICAS
• 5-15-2024IF YOU’VE TRIED MEDITATING BUT CAN’T SIT STILL, HERE’S HOW—AND WHY—TO TRY AGAIN
• 5-15-2024RESEARCHERS DETERMINE THE MUTATIONS THAT PROTECT MICE FROM B-CELL CANCERS
• 5-15-2024UP TO 246 MILLION OLDER PEOPLE MAY BE EXPOSED TO HEAT RISK BY 2050 DUE TO GLOBAL WARMING
• 5-15-2024MORE RESEARCH SUPPORTS ANDROGEN TREATMENT FOR BREAST CANCER
• 5-15-2024UNDERSTANDING THE ROLE GUT MICROBIOME–BRAIN INTERACTIONS PLAY IN SOCIAL DECISION-MAKING
• 5-15-2024NEW STUDY IDENTIFIES MECHANISM OF IMMUNE EVASION OF SARS-COV-2 AND VARIANTS
• 5-15-2024RESEARCH SHOWS RECENT RELEASE FROM JAIL A BIG RISK FACTOR FOR SUICIDE
• 5-15-2024RESEARCH COLLABORATION DEVELOPS LIFESAVING ‘ARK’ TECHNOLOGY FOR CHRONIC KIDNEY DISEASE PATIENTS
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• 5-15-2024MOST SLOW RESPONDERS TO TIRZEPATIDE DO LOSE CLINICALLY MEANINGFUL WEIGHT
• 5-15-2024RESEARCHERS IDENTIFY CAUSATIVE GENE IN MOUSE MODEL OF INHERITED LETHAL ARRHYTHMIA
• 5-15-2024TECH ALONE CAN’T REPLACE HUMAN COACHES IN OBESITY TREATMENT, STUDY FINDS

Recently I reached out to an RT who’s been an RT for over 15 years. I pretty much asked if they had advice and how they got into radiation therapy. The response I got was if they could go back they would do nursing and to consider nursing for the following reasons : - its the same amount of schooling - there’s not a lot of options in therapy - you can’t work nights or weekends if you wanted to - the hours can sometimes run late - there are rotating shifts in RT (not exactly sure what that means or how it may be a con?)
Personally, when I read their response my thought was, how are those cons? I would consider most of those pro’s of being an RT vs nurse.
I know there are a few posts on this topic, however I couldn’t find what I was looking for. Everyone on here seems to love their job, but I need some brutally honest RT’s to say if they regret doing RT instead of RN & explain (or if you don’t regret just some reasons RN may be a better option or not?)

Hello everyone. I find myself in a challenging situation and would greatly appreciate your help, as it is affecting me mentally.
I am currently pursuing a PhD in theoretical physics in a European country, with the program expected to last 3-4 years. I am already 1.5 years into the program and am very happy and motivated with my research topic. I work consistently and productively, and enjoy what I do. My supervisor, a knowledgeable man in his mid-40s, is not a good mentor. The lab is small, consisting of 5 PhD students and 1 postdoc, with only the postdoc and myself being international students.
The issue I am facing is the lack of guidance from my supervisor and the strained relationship we have. He shows no interest in my progress, results, or research, and provides zero feedback. Communication is difficult, and it is clear that we both find each other annoying. Despite my attempts to establish regular meetings and get feedback, he has expressed no interest as he said he does not have time for this. I completed a project he provided me with, but it seems he is unsure of what I should do next.
If he was like that to everyone I would feel that the issue is not me. But this is not the case. He follows more or less similar treatment to everyone apart from one PhD student, who is 4 months senior to me. To him, he behaves in a completely different and more supportive manner, like a mentor. It is obvious that he likes him the most. They keep talking about research to each other's offices almost on a daily base sometimes they even talk about small things. Yet, establishing weekly meeting with me is too busy for him. I feel isolated and disadvantaged in this situation, which has impacted me negatively. I consider myself motivated and knowledgeable but my powers have a limit.
I have tried to address this by conceiving and starting 2 projects and seeking collaboration with another professor from a different country. This goes well even though my supervisor continues to show little interest in these projects. I have even discussed this with my therapist, as it makes me feel incapable and insecure, thinking that I do something wrong and sometimes have thoughts that he is racist against me.
My questions for you are:

1. What should I do in this situation? I am reluctant to change supervisors, as I am passionate about my research topic and enjoy the work conditions overall.
2. How can I deal with the insecurities and lack of motivation? These are triggered by overhearing conversations between my supervisor and the other PhD student.
3. I am concerned that the lack of mentorship will harm my career progression. Do you share this concern? While I have grown in independence and can network and initiate projects, I understand this may not be ideal compared to having a mentor like a lot of my peers have.

Apologies for the long post, I want to make it as clear as possible!

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• How old are you? What's your gender? Give us a general description of yourself.
I'm 17 years old about to be 18 this year. I'm a female, about to enter college in a few months but still unsure of the path I want to take. I don have a lot of hobbies a side from reading and dancing.
• Is there a medical diagnosis that may impact your mental stability somehow?
I was diagnosed with GAD. These past month I have been having a lot of panics attacks and now, depression. One of the effects of how I cope with depression is Maladative daydreaming.
• Describe your upbringing. Did it have any kind of religious or structured influence? How did you respond to it?
I grew up in a well-off household, but was taken care of by a caretaker instead of my parents. I never took my parents as religious nor did I felt our household was religious. I remember my grandmother praying every night with the rosary but she's not very imposive of religious practices. That's why I was at awe when I told my mother I don't really belive there's a god and she got really angry at me. I'm agnostic now, I don't really care if there's a god or not, I have more important things to focus on than that.
• What do you do as a job or as a career (if you have one)? Do you like it? Why or why not?
I'm currently in my final year of high school (or in my country, SHS). I'm thinking of getting in the field of biomedical engineering. I've always knew I wanted to be in the field of medicine, but I have realized that I was not meant for the "service" part of it, rather more of the research and how to apply biology in medicine.
• If you had to spend an entire weekend by yourself, how would you feel? Would you feel lonely or refreshed?
I would feel refreshed. Maybe, a bit used to it? Though, there would probably be points where I feel lonely or scared, but then I'll realize that I enjoy more being alone when people are constantly around me. Especially, when I'm focusing on something.
• What kinds of activities do you prefer? Do you like, and are you good at sports? Do you enjoy any other outdoor or indoor activities?
I'm not very good at sports, the only sport I play was golf and I was okay at it. I definitely enjoy indoor activities for the most part, but I do love eating outside and exploring new restaurants.
• How curious are you? Do you have more ideas then you can execute? What are your curiosities about? What are your ideas about - is it environmental or conceptual, and can you please elaborate?
I feel like in a horror movie, once you leave me alone and I hear a sound, I'll definitely check it lol.
I think I like bringing my ideas to life. In a practical sense of having an idea to go somewhere to having a crazy idea on "what will happen if I do this and this?", and you'll definitely see me do it.
Well, my ideas ranges to anything that I find interesting really. I do have a huge interest biology and most specifically, medical biology and health physics.
• Would you enjoy taking on a leadership position? Do you think you would be good at it? What would your leadership style be?
I avoid leadership as much as possible, or all the time basically. Even though I probably should lead the group I usually just stay quiet and support the one leading the group if they need help.
I don't think I would be good at it, I'm not a decisive person at all, and on top of that I get easily anxious and think that I'm doing is wrong. Unless, I'm very confident of my ideas.
• Are you coordinated? Why do you feel as if you are or are not? Do you enjoy working with your hands in some form? Describe your activity?
I'm very clumsy, and I often feel a bit detached from what is happening around me. I do enjoy working with my hands, currently, I'm making an arts and craft object for my friend for her upcoming graduation and a gift. And I just feel at peace I guess when at some point I'm doing the same thing over and over again and I can space out for a bit.
• Are you artistic? If yes, describe your art? If you are not particular artistic but can appreciate art please likewise describe what forums of art you enjoy. Please explain your answer.
That's the one thing I am absolutely sure I am not. I do enjoy theater and music. I grew up with the influence of ballet when I was younger and everyone's dream around me is to be in theater. I guess, being surrounded by those influence and made me appreciate the little technicalities I see in those shows.
• What's your opinion about the past, present, and future? How do you deal with them?
My past is a mess, present is fine, and future is scary.
I always deeply regret that I could have done something more in the past, but present me is surviving and I consider that as fine. On the subject of the future, I'm scared of it, I'm scared of failing.
• How do you act when others request your help to do something (anything)? If you would decide to help them, why would you do so?
I'll definitely help them ASAP, I feel a bit responsible as someone they confided in for help.
• Do you need logical consistency in your life?
I'd say, I definitely do.
• How important is efficiency and productivity to you?
I do get satisfaction when something is done. Efficiency is of course very important for me, especially, in the things I need to do. Productivity is something that I feel good about, but there are days where I don't mind that it's not there.
• Do you control others, even if indirectly? How and why do you do that?
At some point, yes? I feel like I do control them in a sense if that something affects me and if I don't want to do something or for them do to something, I do meddle in.
• What are your hobbies? Why do you like them?
Reading, it feels like an escape from everything that's going on around me. While dancing is the same thing although more frustrating.
• What is your learning style? What kind of learning environments do you struggle with most? Why do you like/struggle with these learning styles? Do you prefer classes involving memorization, logic, creativity, or your physical senses?
I struggle the most with creativity, I feel like aside from I'm not a creative person, I feel like I'm doing something wrong. I do like logic and the application of it's theories, and memorization too.
• How good are you at strategizing? Do you easily break up projects into manageable tasks? Or do you have a tendency to wing projects and improvise as you go?
I'd say I'm okay at it? Not an expert at it. I like to do things as I go. So, if I feel like this is a task I should do, everything else follows.
• What are your aspirations in life, professionally and personally?
To finish my degree, get a scholarship from an another country for my masters, work in a lab, and make a good living.
• What are your fears? What makes you uncomfortable? What do you hate? Why?
I hate the dark, I hate what's in them. I'm also scared to fail, I don't want other people to pity me.
• What do the "highs" in your life look like?
Doing well academically, socially active, organized, and contented.
• What do the "lows" in your life look like?
Escaping reality, trying to off myself, and withdrawing from everyone.
• How attached are you to reality? Do you daydream often, or do you pay attention to what's around you? If you do daydream, are you aware of your surroundings while you do so?
When I daydream often, for me, it's a sign that things aren't doing well mentally. I try not to pay attention to the people around me, almost like it's intentional that I do that.
• Imagine you are alone in a blank, empty room. There is nothing for you to do and no one to talk to. What do you think about?
What will happen to me in this room? And I need to figure out why I am here.
• How long do you take to make an important decision? And do you change your mind once you've made it?
I am an indecisive person, but I do often change my mind on something if the other decisions start making sense for me.
• How long do you take to process your emotions? How important are emotions in your life?
It does take a while, I usually brush my feelings until I realize that it's on it's final leg. I do think emotion is needed, but too much is a burden.
• Do you ever catch yourself agreeing with others just to appease them and keep the conversation going? How often? Why?
It really depends on the topic. If it's just a non-serious or trivial topics, I just nod and don't bother replying at all to them, but if it's a serious one, I try to set my opinions and facts straight.
• Do you break rules often? Do you think authority should be challenged, or that they know better? If you do break rules, why?
At some point you're going to break rules in an institution. I don't actively or seek to break rules, but if the time comes and it's for the better, I will. Also, if the rules don't make sense, I don't even even try to follow it. I think authority should be challenged if there are people suffering or having a hard time under those rules.

Unveiling GPT-4: A Game-Changer in Natural Language Processing
Greetings, Redditors! Today, we're diving into the exciting realm of artificial intelligence with the much-anticipated introduction of GPT-4. Developed by OpenAI, GPT-4 represents a significant leap forward in the field of natural language processing (NLP), promising to revolutionize the way we interact with AI systems and applications. Let's delve into what makes GPT-4 so remarkable and how it's poised to shape the future of AI-driven interactions.
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GPT-4 stands out for its unparalleled linguistic proficiency, powered by state-of-the-art algorithms and extensive training on vast amounts of text data. From casual conversations to technical discussions, GPT-4 demonstrates an impressive fluency, coherence, and context awareness across a wide range of topics and domains. Whether you're discussing literature, pop culture, GPT-4 is ready to engage in meaningful dialogue with remarkable accuracy and understanding.
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What sets GPT-4 apart is its advanced contextual understanding, allowing it to grasp nuances, infer implicit meanings, and maintain coherence over longer passages of text. Through sophisticated attention mechanisms and contextual embeddings, GPT-4 can tailor its responses to specific contexts, resulting in more relevant and insightful interactions. Whether you're seeking information, generating creative content, or analyzing sentiment, GPT-4's contextual prowess ensures a level of sophistication that's truly remarkable.
Flexible Fine-Tuning Capabilities
Another standout feature of GPT-4 is its flexible fine-tuning capabilities, empowering users to customize the model for specific use cases and domains. By fine-tuning on domain-specific data or task-specific objectives, GPT-4 can adapt its knowledge and behavior to suit the unique requirements of different applications. Whether you're building chatbots, creating content, or analyzing text data, GPT-4 offers a level of flexibility and scalability that's truly empowering for developers and researchers alike.
Ethical Considerations and Transparency
Of course, Indeed, the deployment of advanced AI systems like GPT-4 involves significant ethical considerations. OpenAI has implemented various measures such as rigorous testing, adherence to responsible AI guidelines, and transparency to ensure ethical and responsible usage. These steps are crucial for building trust and ensuring that AI technology is used in a way that benefits society while mitigating potential risks.
Potential Impact and Applications
The potential applications of GPT-4 are vast and varied,In education, GPT-4 enhances personalized learning, virtual tutoring, and educational content creation. In healthcare, it aids medical diagnosis, patient care, and drug discovery. For businesses and customer service, GPT-4 streamlines communication, automates tasks, and enhances user experiences.
Conclusion
In conclusion, the arrival of GPT-4 marks a significant milestone in the evolution of artificial intelligence and natural language processing. With its unmatched linguistic proficiency, advanced contextual understanding, and flexible fine-tuning capabilities, GPT-4 holds the promise of transforming how we interact with AI systems and applications. As we embark on this exciting journey, let's embrace the potential of GPT-4 to drive innovation, foster collaboration, and shape the future of human-AI interaction in meaningful and impactful ways.

Just reaching out to see if anyone else has experienced the same as me. I've had migraines since I was a teenager (in my late 20s now). As the title says, whenever I am suffering an attack, right from the aura all the way through, I find it much much more comfortable to speak and somewhat think in another language. When I was a teenager this was German, as it's what I learnt at the time, but now it's French (my partner'sl language). I have put effort into learning it, so I have a good grasp of words, but I still know less than in English. I'm wondering whether: a) My brain reaches for another language as I know less words in that language, so the "dictionary" of words to sift through is less b) the part of my brain that speaks English shuts down or struggles during an attack (I have lost the ability to remember English words in the past).
Has anyone else experienced this or know of any research on the topic?
Thanks!

Hello fellow Nyets and beloved Malaysian~!
Needing your help because somehow it is really hard to find Malaysian participants when it comes to sustainability or green topics. :(
I am currently doing a research to check how much awareness Malaysian have when purchasing green or eco-friendly products. Do you just buy and trust it whenever it is green color and with words like 'eco', 'green', '100% natural', '0 this and that'? Or you think they are just bluffing and gimmicks?
I hope you can participate in my research anonymous survey. It will only take 5 - 10 minutes to answer them.
https://strathbusiness.qualtrics.com/.../SV_57trk4ohVZiU07Q
Your input not only helps us understand consumer awareness but could also inspire reflection on your everyday shopping decisions.
Thank you for your effort in making Malaysia a better and greener place!
Please feel free to share the survey with your friends. We can also discuss about this topic here, sharing experiences, and I can also answer any question that you have. :)

Edit: I seem to have miscommunicated. My professional opinion is that babies are very much capable of learning from day one. I'm wondering where the idea that they aren't is coming from. The people I've heard it from seem to think it's research backed, and one was a pediatrician.
I'm a newborn care specialist (what used to be called a night nurse) and I often hear parents and pediatricians say that it's a known fact that babies can't learn or develop associations before 4 months. This is usually given as a reason to not try to teach them to sleep independently at all before that time. While I support waiting until 4 months for formal sleep training, in my personal experience babies are absolutely capable of learning from day one. I do a lot of work with the babies I work with to gently teach them to sleep independently, and most of them are sleeping through the night by 4 months. Anyone know what research is backing up the statement that babies can't learn before 4 months?

Currently I'm at university nearing the point of writing a bachelor thesis. I'm 20 years old. And I feel so helpless. It feels like I forgot why I chose to do a Bachelor of Computer Science in the first place. Writing a bachelor thesis. About what? I literally have no idea. I'm already only going to lectures because I got no life. Even to the lectures I like. I literally only go to them because I got nothing better to do in my free time. It's depressing. It is clear that I lost the *why* in studying Computer Science. Primarily I went to university to get a better social life because my school social life was bad. But seriously, expecting a better social life in Computer Science is definitely a funny thing.
I went to university because somehow, magically I expected that my life would turn around, that someone would "give" me a purpose. But the more and more attend higher classes at university, I start to see a problem: You don't go to university because someone tells you to. You go to university because you *want* to. That's where my fifth life crisis starts to begin.
In my first semesters all courses were mandatory. I had a pupose: If I didn't attend these courses, these lectures, don't submit my exercises, don't find a group for group work, I will have a problem. That problem is not passing these mandatory classes. There was a clear purpose. Like in school.
Then, I got into higher semesters. And I started to see a problem. For the first time I had the *choice* between different elective courses. *I* had the choice to choose something which interests me. This choice overwhelmed me so much that I was close of dropping out. It made me feel purposeless because there way no *why* in taking these courses, just out of an intrinsic motivation. No external pressure. I didn't have to submit exercises anymore. Sure there were still discussions about voluntary exercise sheets. But no grading, no submission, no feedback. No group work anymore, so the *only* social element of my life went away, too. It is hard. It is hard waking up in the morning and knowing you will be all alone in the lectures by yourself, then going alone to the cantine to eat, then going home alone to do *voluntary* exercises alone.
Somewhere, in late high school, until now, I lost every purpose in life, both non academically but also academically. I never managed to develop an intrinsic motivation. My parents always told me what to do. My school always told me what to do. But because of my autism, my adhd, I had ZERO idea what to do on my own, nor was I ever capable of social connections. So I either start to drown myself in academic work, or other addictive things. Both is not healthy.
Well, of course there was a purpose: These courses go to be able to write my bachelor. But why do a bachelor? And doing all the requiremenets just because of the bachelor feels dumb. Because I *had* to, not because I *wanted* to. I could also just write out a paper written as "[My name] is the king of the world" and that wouldn't make me feel better.
What is the purpose?
I don't want to go to university, leave university, just to get a paper handed out in the end where it's written "Firstname Surname got a bachelor in subject x", being a random number who did the bare minimum to pass all previous courses, did the bare minimum to write a bachelor thesis about a generic topic, who had no social life, no contact to anyone at university. You realise how depressing that is when you got no life outside university?
This sub is not about depression, I know. But my problems are twofold, of which a large part is having a universal fifth-life crisis, no clear purpose in "why" I go to university. I literally have no hobbies. No friends. No purpose in university. Let me get one thing straight: The subjects, or the difficulty, are not the problem. I'm in my 5th semester right now and didn't fail one exam once, even though I didn't went to any lecture last semester because I was fed up of isolating myself outside.
Why should I do anything, why should I do anything, studying, going to lectures, doing voluntary assignments, learning the content, asking questions in the lectures if I got no social life? No one to discuss the topics with, no one to talk about the amazing thing Computer Science is? Who cares what I know, what I am capable of, what my bachelor thesis is if no one reads it? If no one wants to listen to my opinions, my ideas? If I'm just a number?
I got no purpose! No intrinsic purpose! I *need* others to give me purpose. And that's bad for university. To me a life, at university, without a social element is purposeless. University *needs* interconnection, discussing ideas, exchanging ideas. I got neither of that, nor outside university.
How are you able to have an intrinsic motivation at university? How are people able to write papers? Alone? How is that physically possible? To me, sitting infront of my PC, alone, writing a Bachelor thesis, doing literature research, alone, on my PC, going, alone, to the library for literature sounds like the most DEPRESSING thing I have ever witnessed. How do people manage to do what? How do people manage to do things ALONE? Because they got a social net? People to talk to? I don't get it.
I see the point of my Bachelor thesis infront of my eyes and afterwards I see a gaping void in my life. It scares me. *What* to do after a Bachelor thesis, alone? Masters? Alone? Again 2 years of torture? Doing work at some random company? Alone? I don't want to be alone anymore. I'm tired of it. Sick of doing academic work alone. Sick of doing *anything* alone, outside, inside my apartment. Everywhere. It's so dumb. So pointless.
So, please tell me, *why* should I do *anything* at university out of an intrinsic motivation? *How* do you get an intrinsic motivation to do things at university?

Hey folks,
I'm starting to take my first steps with Proxmox, and I've hit a roadblock that I'm not sure how to handle. I've researched this topic a bit, but can't really understand what I should do.
In my host (Proxmox VE) I have installed acme.sh (ACME Shell script) to generate certificates for my private domain that I use in my homelab (some endpoints have external access through Cloudflare). I'm doing this in the host because I'll need to share the certificates with multiple LXCs, and this way I only have to generate one wildcard certificate, and not multiple (per LXC that needs them).
Now I'm setting up an LXC for Docker, so that I can run some containerized applications, such as Traefik, to use as a reverse proxy for all my local services. My goal is to share the certificates on the host with the LXC, and then from the LXC to the Traefik Docker container.
I've figured how to share them:

• From the host to the LXC: Bind mount points
  • mp0: /opt/acme.sh/example.com_ecc,mp=/etc/ssl/example.com,ro=1
• From the LXC to the Traefik Docker Container: Bind mounts
  • --mount type=bind,source=/etc/ssl/example.com/fullchain.cer,target=/etc/ssl/certs/example.com.pem,readonly
  • --mount type=bind,source=/etc/ssl/example.com/example.com.key,target=/etc/ssl/private/example.com.pem,readonly

Then, the Traefik configuration has something like this:
yml tls: certificates: - certFile: /etc/ssl/certs/example.com.pem keyFile: /etc/ssl/private/example.com.pem options: default: minVersion: VersionTLS12 sniStrict: true
But this is what I get when I look at the container logs:
ERR error="open /etc/ssl/private/example.com.pem: permission denied" filename=tls.yml providerName=file
The strange thing to me is that using the terminal, I can do this:
pct enter 101 docker exec -it traefik sh cat /etc/ssl/example.com/example.com.key
And I get the output, the root user inside the Traefik Docker container and read the file contents, but the traefik process cannot. What am I missing?

To preface this post, I want to give the disclaimer that like many things, there is not a black and white answer the question. I'm writing this as an experienced tech professional, and the information provided is based on opinion.
To start with. A little bit of history..
The golden age of software engineering(and similar jobs) is over. At least for the next 5 - 10 years. I don't think this is an unpopular opinion. The reason why between the years of 2010 - 2022, these jobs exploded, was because of the boom of the internet for commercial and personal use.
This is different from the dotcom boom of 2000s, where the internet was just starting and most of the products being created were for basic things like: putting banking on the internet, putting videos on the internet, etc.
The boom in the 2010s was related to the widespread popularity of commercial and personal products. Things like Uber, Spotify, and Salesforce. With the sudden increased usage of the digital world, there were MILLIONS of companies rushing to create digital products.
However, we're starting to see the rise and fall of some of these products, millions of startups failings, and less VC funding. In case you don't know, VC stands for Venture Capital, which are basically investment companies that give money to other companies to help them grow and develop, in return for partial ownership of the company.
As the industry began to mature, successful companies started to emerge, and many more started to fail.
The present day..
Software engineering and like jobs will continue to be important, and there will be a high demands for these engineers. Nearly every company will still need a website, a place to manage their data, and people to manage their hardware. BUT.. the basic technologies they need to run their company will become more efficient. AND there will be less research and innovation because the a lot of the trial and error already occurred.
We're in a weird spot where the demand for workers is now decreasing from it's recent peaks, and the supply of workers is now increasing because of how all the benefits of being a software engineer in the past decade.
This has really unfortunate consequences for any recent graduates or others trying to break into the tech field. There are WAY more beginning career people than jobs available. Which is made even worse with the amount of layoffs there are, where mid-level employees are now having to settle for entry level jobs.
What can we do?
I have two pieces of advice for people interested in the topic, or wanting to break into the field but can't. Try breaking in from a adjacent field, where you can get some exposure to tech. Things that data entry, analytics(this can be finance, supply chain etc). Then try to learn as much as you can from the tech people at your company.
The second piece of advice. Go into a different field. Software engineering is not for everyone. You have to learn and understand some relatively complex topics, and it's becoming harder and harder to be competitive in the industry. Healthcare, supply chain, and many other industries are booming right now.
Understanding history, you can see that certain industries will rise and fall. For the near future, technology might be one of the harder careers to break into. Something like healthcare would be that's expected to grow exponentially. The average population of the world is getting older, as less and less people are wanting to have kids. There will be higher demand for healthcare professionals and healthcare technology.
Do your best to review and understand these trends, and hopefully you can create a good life and career. Best of luck!
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Previous weeks!
Thursday Reading and Recommendations is intended as bookish free-for-all, for the discussion and recommendation of all books historical, or tangentially so. Suggested topics include, but are by no means limited to:

• Asking for book recommendations on specific topics or periods of history
• Newly published books and articles you're dying to read
• Recent book releases, old book reviews, reading recommendations, or just talking about what you're reading now
• Historiographical discussions, debates, and disputes
• ...And so on!

Regular participants in the Thursday threads should just keep doing what they've been doing; newcomers should take notice that this thread is meant for open discussion of history and books, not just anything you like -- we'll have a thread on Friday for that, as usual.