Losartan hydrochlorothiazide micardis hct compare

My hypertension has ended and I'm being taken off meds

2024.05.11 14:11 GTCapone My hypertension has ended and I'm being taken off meds

So, my doctor diagnosed me (36M) with hypertension due to alcohol abuse and smoking at the beginning of the year. I was consistently at 150/80 or higher and also had high cholesterol (luckily, my liver was still doing okay). As a result, he put me on Nifedipine and I checked myself into a rehab clinic.
My BP came back down to a healthy level within a week of sobriety, medication, and a better diet. While in rehab, my BP cuff broke and the VA screwed up the order for the new one, so I haven't been monitoring it for a few weeks while the new one came in. I'd been stable for 2 months at that point though, so it wasn't much of a concern.
Well, about a month ago I start reading at 90/60 at the doctor's office. Then, 2 weeks ago, I started getting dizzy when standing up and became lethargic during the day (after taking my BP medication). Finally, I got my new BP monitor this week and it turns out I've been consistently at 80/50 and only up to 100/60 prior to taking my meds. My cholesterol has also completely returned to healthy levels (107 total, 53 LDL). My doctor returned my call yesterday evening and we've decided to titrate me off the medication (now Losartan and hydrochlorothiazide).
It turns out alcohol abuse and smoking is bad and you should eat a vegetable every once in a while. Who knew?
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2024.05.08 22:46 SPQRsmash Need help with blood test results.

My doc has asked me to do further testing next week due to slightly low HCT. 33M 6"1' 280lbs Caucasian Smoker:Not anymore (last cigarette was 10+ years ago). Drinking: occasional drinker. Medication: Losartan Hydro combo and Amlodipine I get some bad anxiety and just wanted to see if there's anything I should worry about.
WBC AUTO 7.3 RBC AUTO 4.55 HGB 13.8 MCV 89 MCH 30.3 MCHC 34.1 RDW 14.4 PLATELETS 235 HCT 40.5
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2024.05.07 02:05 beckyloowho Every Single Iron Number Extremely Low on Blood Work with pain, numbness and tingling in extremities (31F)

I’m a 31F with a partial hysterectomy and other surgeries I’ll list shortly. In the last year to two years I’ve been dealing with increased pain in my joints, headaches, fatigue, fogginess, short temper, numbness and weakness in my extremities. I had a nerve conduction study done that showed nothing abnormal, however when he stuck my lower leg with the needles for the nerve conduction study I barely felt it. They did an MRI of my brain and found a small mass on my pituitary gland that we plan to do a focused MRI of shortly.
I’ve had the following surgeries in the past 4 years:
Tonsillectomy (2022) Partial Hysterectomy (Ovaries only left, 2020) Liver resection and gallbladder removal (2020, benign hepatic adenoma caused by birth control)
Medications:
AM: Wellbutrin XL (300mg, 1x daily) Metoprolol XR (100mg, 1x daily) Losartan Potassium (100mg, 1x daily) Topiramate (25mg, 1x daily) Vyvanse (70mg, 1x daily)
PM: Metoprolol XR (50mg, 1x daily PM) Protonix (40mg, 1x daily) Belsomra (20mg, 1x daily) Valium (5mg, PRN)
Spravato (84mg intranasal biweekly)
Rheumatologist diagnosed me with hypermobile syndrome and fibromyalgia after seeing me for 30 seconds but ran blood work just in case.
The numbers that have me concerned are the following from the blood work the rheumatologist ran:
HGB - 9.8 (Result confirmed by repeat analysis) HCT - 33 MCV - 67 MCH - 20.2 MCHC - 30.1 RET-HE - 21.90
What do my next steps need to be? Who do I need to see next? Should I get a second opinion? Any advice is greatly appreciated because I’m scared with the lack of answers and the run around I’m getting from every specialist.
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2024.05.06 19:52 SVT-Shep Switched to SubQ, when should I retest?

Was pretty dialed in on IM in terms of numbers, but felt like I was getting some gnarly peaks and valleys and a few other things that may or may not be due to exogenous test usage. The only part I was 100% battling from test is the good ol HCT/RBC-related shit, which is one of the reasons for trying subQ.
Giving subQ a shot to see if I see any improvements. Have been doing it for a little over a week and overall feel "better" so far. Could be partially due to other factors as well, so not making any claims just yet.
My question is- when should I retest to compare numbers to IM? I saw someone mention 12 weeks to get "saturated" but that seems illogical, since I'm not really starting from day 1 on Test C. It's already in my system from months of IM...
Any input would be appreciated.
submitted by SVT-Shep to Testosterone [link] [comments]


2024.05.06 19:09 Emotional_Tiger_3583 Tachycardia and new prescription of Carvedilol

Hi there, I recently came off of an episode of hypo to hypercalcemia with very high blood pressure and then orthostatic pressures that coincided with tachycardia throughout the day. I was admitted to the hospital for four days discharged. I went to see the cardiologist and he recommended the beta blocker Carvedilol. I think it will help with my elevated blood pressures as I’m also taking amlodipine however, I’m concerned because I do not want to end up orthostatic static or too low as my pulses can be anywhere from 60 to 130 depending on what’s going on. Sometimes at rest it sits at 115. My heart rate never seems to drop too low so that’s a good thing but my blood pressure tends to drop throughout the day and then elevates when I sleep. Today at 8:30 in the morning when I saw the cardiologist, my blood pressure was 152/107, pulse of 105 he didn’t seem too concerned. He did an EKG and it was fine. Anybody have any experience with tachycardia and taking this med and what I should expect? I used to be on losartan and hydrochlorothiazide but they’ve now discontinued that.
submitted by Emotional_Tiger_3583 to SinusTachycardia [link] [comments]


2024.05.03 16:24 One_Cabinet_1706 Bloodwork - 1:160 ANA/RCB/HCT/GLOB

Bloodwork - 1:160 ANA/RCB/HCT/GLOB
Been chasing mystery autoimmune since childhood. Always had aches and pains in arms and legs w/ no positive ANA. Then fast forward, 2 years ago had positive ANA 1:160 speckled, negative autoimmune panel, still same body aches every now and then w/ swollen lymph nodes behind ears (normal ultrasound). Just had my bloodwork done again and still 1:160 ANA homogenous + low RBC, low HCT, high globulin.
Symptoms: back pain when standing long, feeling like I’ve been hit by truck day after doing a lot with my body, migraines, tinnitus. Nothing majorly impacting my day to day.
Now - positive ANA 1:160, everything else in normal range except RBC + HCT (low), globulin (high) - all the low/high are just barely outside of range (+-1/2)
August 7 - my WBC, neutrophils, neutrophil #, total protein, and globulin were all high. Lymphocytes were low.
July 22 - my neutrophils and chloride was high, and roc, hgb, hot, calcium, albumin, ast, and alk phos were all low.
No treatment so far, bloodwork has all been for random things but not tracking anything so far. Follow up with doctor scheduled for a few weeks from now.
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2024.05.01 18:56 Ddraig213 Authors and their Fics you personally Like or don't like, and How you judge so.

So I was just on a post of someone asking for recommendations on bad fics to judge if they are as bad as their reputation says, and the various shared recommendations got me thinking about how I judge fics. Several hated fics were ones I personally enjoyed, and as people explained why, I thought it would be interesting to hear how people judge fics, and with those thoughts in mind, which fics they enjoyed or which they didn't to the point you made note of it.
So, if you want to share, please just give a small description on how you judge fics, and based on those parameters, some fics you either liked or disliked.
Personally, I often judge based on three criteria. Setting, Plot, and Writing. I'm also more partial to Taylor centric or adjacent stories, so sorry if they aren't your normal cup of tea.
Setting can be summed up in how the world behaves within the story. While Worm isn't exactly air-tight setting wise, it works, and can be explained by expanding on the unexplored parts. With fanfics, I see it as judging how the story explains what is in the world that is different in Worm, or exploring those unexplored sections. To start with a somewhat popular world setting, the idea that the Slaughterhouse Nine are a black-ops group, therapy group, or are in general not the most repulsive group on the American continent.
For example, in fics like Mauling Snarks that explore the idea of human-shard interactions and have the S9 as a secret therapy group headed by Jack Slash acting as a therapist, using his Master influence to help them control themselves and redirect the uncontrollable impulses to either harmless targets, or use them as tactical weapons against threats. I judge changes like this on how they handle these changes are implemented, how these changes would affect canon and how the story differs from Worm. Mauling Snarks actually did this rather well, having the setting be nearly the same with public changes but having more behind the scenes and PRT internal structures different to explore the bureaucratic changes caused by this choice to explore it. It allows for the idea that the side-effects of powers are more important in story to be seen as realistic, and when several people start to fixate on these ideas, it comes off as interesting to me.
A fic that didn't do this well in my opinion is Section Nine, which has a similar premise with some add-ons, but it is not introduced well or handled well. With the S9 being a black-ops group under Legend used to take out problematic groups that can't be dealt with legally, along with Toybox being a private think-tank made by Hero, and the two partially merging after Hero's death to work together. However, the world changes are completely unrelated to this pretty important change, and introduce other ideas that are never explored or their ramifications considered. While a fun premise, all it did was slightly adjust how the main cast behaved and some of their allies were, but it also could've had the near identical plot line without introducing any of the changes at all, making it feel extremely redundant and deceptive. I can casually think of several ways to do so. Especially as, and this is the biggest sticker, the canon S9 members essentially don't show up or do anything beyond act as a plot device. Barely any canon S9 members appear(I can only remember Jack and Riley showing up at all), and they all have minimal effects on the plot. There only real effect is that the S9 attack Brockton Bay, prompting the killing of E88 capes. That's it. The only reason I can't think of a way to easily write the S9 out without major rewrites is to introduce an easy way to excuse killing the E88 without having to slide an arc or sub-arc in, or rewrite another one. It's stuff like this that tends to turn me off fics pretty quickly, introducing a premise and proceeding to use and then discard any part that makes it interesting.
Plot is the story framing itself, and how the story progresses. I judge it based on the promise the story gives with either its synopsis/summary, how the first couple chapters go to say what the story will do, and how the plot progresses. Does the story promise what it gives? Does the story have a logical progression from A to B. In fusion fics, this is judged in how the inherent promises made by the individual stories are addressed. In Au/Alt-powers, this is judged by how the changed power is affecting the story.
An example is Trailblazer. The story promised a fusion of Worm and Gundam, and it delivered well in my opinion. While also a great example of Setting, as it has a lot of Au elements, fusion elements, yet preserves enough similarity with that is doesn't feel like a completely unrelated fanfic wearing Worm's skin, but what I like most about it is the plot. Worm is grimdark/grimderp setting that espouses a disbelief in the inherent goodness of people and the inevitability of failure . Gundam is a franchise that looks at the ugliness of humanity and looks for the beauty hidden behind it, the last spark of hope. To borrow the catch phrase from another property, Gundam stories "fight for all that is beautiful in this world." No matter what is currently occurring, nothing should stop you from fixing it. Gundam stories are about the effects of war and how people attempt to address them. In Trailblazer, that war is the Golden War, where Scion is defeated, but his death leads to very different broken triggers, and the PTSD that was formed makes very different antagonists. That promise is explored in Taylor, who holds the same issues canon Taylor does, but instead of manifesting powers to try and cover up her trust issues, she is given tinker abilities that allows her to fix the issues, and in the process, allows Taylor to flourish instead of rot. Taylor's canon character can be summed up by one of Ryuugi's more memorable quotes. "Taylor was born to be a 90s Magical Girl, but was taught to be a 90s Supervillain." Trailblazer doesn't teach her this time, allowing her to come to believe in humanity again. Instead of quite literally beating it to death, she answers the problem with a solution. It's plots like these I personally enjoy that actually try to uplift characters and allow them to grow into their truest self, their best. A couple others also do so quite well, Like Fabius's Visitors from Afar and Miraculous Escalation, where the inherent promise in fusion fics are addressed extremely well, blending the philosophies of the two stories in satisfying ways.
For Alt-powers/Aus, I can actually do an interesting compare-contrast between two stories that have the same premise, start, and promises, but go in wildly different directions, to one's glory and the other's failure. The idea of Taylor accidentally killing the Butcher before her cape career can properly start, leaving her with worrying about the Butcher's legacy, even as she apparently nullifies the insanity of the inheritance. Here comes the new boss and Inheritance succeed and fail in this idea respectively. HCtNB has Taylor becoming an altruistic tinker that is willing to go against the PRT to do right by those she believes deserve a second chance, due to her fears about how she herself would be judged, and struggles as the suggestions made by the more malicious past incarnations become more and more tempting as the stability of Brockton starts to collapse. Inheritance has Taylor fail to resist the Butcher from basically the word go, quickly falling into the Teeth and causing the Mad Max gang to get worse then it ever was before, the PRT and Protectorate failing to even look competent even with the legitimate danger Taylor poses because the author has a lot of issues with their fics, for some reason making the idea of taking human trophies seem like a small blunder comparable in scale to accidentally forgetting to bring a pencil to class.
Finally, Writing can be summed up with just how well they write out the ideas they are trying to convey, and what choices they have their characters make and how they presented to behave. The first half is easy to expand on with a basic test. Does the word choice and grammatical structure make Wattpad writing look like the peak of eloquence? Because let me tell you, it feels like half the writers on that website don't even speak english. The later half is the judgement of whether the in story behavior of characters make sense. While Plot judges whether the over-arching plot itself makes sense, Writing is the smaller moving parts that cause plot progression. Character choices, events that occur due to previous events, character characterization and reactions. Material like that.
While I don't necessarily have a story that is a shining example of good character writing or one that is repulsive, a plot line in a story I liked comes to mind. In Outcry, Miss Militia, who is commonly characterized as being a rule follower to the point of stupidity, breaks the law for personally satisfaction by breaking ranks to hunt down and execute Coil, and when he surrenders, she tortures him before executing him, even as Dinah is trapped and forced to watched. The Miss Militia is written to be the Hannah from canon, being the rule-follower and strict character that would never conceive of breaking laws for personal desire. This is a culmination from when Miss Militia is the first hero to talk to Taylor after her trigger burns down Winslow, to learning that she can't fulfill her promise to Taylor of getting justice and how much it disgusts her, to having to know that Taylor breaks down learning the first person she trusts after her trigger lied to her ad used her, and Coil using that break to turn Taylor into a rampaging monster that took over a hundred lives while essentially comatose. So when Lisa's machinations allow for Coil to be vulnerable, Miss militia proceeds to break into his base, which not hidden now that both the E88 and ABB assault it to get revenge on Coil, kills basically anyone who gets in her way, and proceeds to start talking about how she'll struggle not to enjoy this, and expects him to scream. Miss Militia proceeds to threaten Lisa when she turns herself in the help Taylor, and is seconds away from painting Lisa's brains across the wall. The entire descent is beautifully displayed, somehow being completely obvious to be coming yet so out of character that you would never expect it without having read it.
With all these in mind, the stories I mentioned as good examples are fics I recommend, with Mauling Snarks being an "eh" fic and exception, as while it isn't bad, I wouldn't recommend it. While good in World framing and decent in writing, the plot is relatively weak, and writing has lots of receptive jokes that inflate the size to the point that it is a slog to get through. Trailblazer is a personal favorite.
I recommend Mp3 stories, even Taylor Varga, though for what may be an odd reason. Mp3 fics all tend to fall into the same formula, but executed very differently. They don't like writing angst, so they proceed to murder anything that could introduce it, and then introduces an unbalanced effect to the plot, normally through Taylor, and then writes the story from that. It's why I like Varga and not Snarks. Varga is just Taylor having fun with demon lizard powers, and dragging everyone around her into her insanity, plot be damned. The 9 got killed by a redneck, the endbringers are pissing themselves as Simurgh tries to figure out some way to make peace with the lizards along with Leviathan trying to warn the humans about the dangers of lizards from the sea, there is nothing to make threats when Taylor can grow to be several times the size of Behemoth. Snarks still tries to have a serious plotline and moments.
Ack stories more often then not are good for similar reasons, though through talking with others, I've learned that Ack has some issues that may or may not have been nuked to oblivion over on QQ, of which I refusing to search for because I'd rather not scar myself. From what I've gathered, he wrote some pretty weird shit earlier in his career, causing either QQ or himself to erase essentially everything from what I'm willing to look up, but from what I've seen as a sfw only reader, he seems to have fixed this, and will often use his readers to steer him in plots to prevent that issue. Only warning I can give is to not look through his nsfw stuff, as it can taint your enjoyment of his better fics. His fics often revolve around one element and that idea is run with, the story flip flopping between serious and goofy. While not at the standard of longer and serious fics, I recommend them for lighter reading. Giving Taylor PtV min-maxed for murder, having Danny be John Wick, Emma triggering in the alley leading her to join Taylor in heroics, giving Taylor Lung's power on steroids, there are plenty to choose from.
Slider also falls into this category of shorter comfort fics, though they did write the longer Mutant Deviations. Slider differs in that they tend to try and humanize a commonly non-humanized character in unique ways, leading to more unique cases, or generally having more character and introspective moments. Taylor adopted by Purity, being the daughter of Skidmark, Regent being as bad as his siblings leading to both Taylor and Lisa being traumatized.
Aggrippa is similar in Wake-up Call and Wordsworth, though they tend to use the sfw/nsfw line as a jump rope, but the story is very much an exploration of character driven stories, with a chapter in Wordsworth that made me feel bad for the Thinker without excusing a single atrocity, even expanding on them. The idea that Taylor's shard, as she was tricked into drinking a Cauldron vial with the Nemesis program, is a shard made by Eden to record the stories of the species they interact with, and as Eden struggles to understand why they are told, the shard grows. It eventually grows strong enough to give Eden a sense of empathy and morality, but as Eden is distracted by the newly formed understanding, they crash, leading to their death before they get the opportunity to atone for their crimes.
For more serious authors, the writer of Outcry, LD, Trailblazer's Endless, and Fabius Maximus are great. There are some fics that have a similar vibe, like Weaver Option, though you need to be patient with it, as the author was not as mature a writer as necessary when the story was first being written, but has cleaned up their ability nicely.
The fics I gave as bad examples are in the "do not read" pile without fail. Both were written by Pendragoon, who has several extreme flaws as a writer that make his Worm fics by and large unreadable without ignoring over half the fic. I think the biggest is that Pendragoon seems to have a weird persecution complex, believing anybody not liked is being unfairly judged and overcompensates by making everyone worse while also trying to justify the unliked character's actions without addressing or even acknowledging the issues that got them that status in the first place. It's not the only issue, as they also seem to hate their audience or subscribe to far into the idea that all publicity is good publicity, but my overall experience with them is to use a 15 ft pole when dealing with them, or to not at all.
I don't have as many bad stories and writers, as I tend to drop and forget unliked stories. There are a couple stories I could name, but from what I've seen, it seems to be an example of immature writer over bad writer. I just give the suggestion that, if the story appears to already be of decent length, give it a couple chapters to work out the kinks before judging too harshly.
submitted by Ddraig213 to WormFanfic [link] [comments]


2024.04.30 23:35 ForensicFulcrum Can someone help me?

Can someone help me?
Can someone help me with my results? Last month my ferritin was at a 3, and my RBC were quite low. I have been taking ferrous sulfate (and vitamin C) for over a month now. I was anemic, now to my understanding I am just iron deficient without the anemia. I had to go to the ER yesterday because of the awful side effects I’ve been having. When I was anemic my side effects were bad, but a month later after being on supplements, they have gotten worse, now with extremely painful bloating. For whatever reason, the doctor told me she specifically didn’t test my ferritin levels. These are my new blood work results. Should I be worried that my RBC are too high? I don’t know how to go about fixing what is low in these results either. I appreciate any help anyone can provide! 🙂
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2024.04.30 02:35 WhatHappened323 Blood Pressure Surges, PVCs, Tremors, Sharp Thigh pain

In August, September, and October of last year I had seven to ten day periods of hypertensive states. Blood Pressure could surge to 200/110 with heart rate up to 165 and return to normal. This eventually went away and I returned to normal. These were similiar symptoms to someone who a pheochromocytoma. I went to have a stress tecst and was negative.
Januray 3rd, it all started again. I began having intense headaches, sharp pain in my left thigh which corresponded to tightness in my neck and headaches and symptomatic PVCs. This time, I was prescribed losartan, then hydrochlorothiazide, and then metoprolol. My blood pressure varied from 90/60 to 180/112.
I have had MRI of the brain, abdomen, and a CTA. All have come back negative. Occasionally, I have internal tremors in the neck to head area.
In March, my blood pressure seemed to somewhat stabilize. However, I began to have more and more PVCs. I still have strange random sensations of shortness of breath, tightness through my neck, and a sharp pain in my left thigh which corresponds to headaches and pvcs.
I finally had a sleep apnea home study in March and began CPAP at the beginning of April.
I was prescribed flecainade because one cardiologist thought that I was having variable blood pressure due to the PVCs and the sympathetic nervous system.
January, February, and most of March I was out of work. I am back to work and still not back to normal. No-one seems to know why I have a striking pain in my left thigh that seems to correspond to strange heart palpitations, headaches and chest pain as well as smaller surges in blood pressure. I randomly get tightness in my back and chest mixed with shortness of breath.
Is there anyone else out there that can relate?
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2024.04.29 10:18 NeuronsToNirvana Abstract; Introduction; Table 1 Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract International Journal of Molecular Sciences [Apr 2024]

Abstract; Introduction; Table 1 Targeting Colorectal Cancer: Unravelling the Transcriptomic Impact of Cisplatin and High-THC Cannabis Extract International Journal of Molecular Sciences [Apr 2024]

Abstract

Cisplatin and other platinum-derived chemotherapy drugs have been used for the treatment of cancer for a long time and are often combined with other medications. Unfortunately, tumours often develop resistance to cisplatin, forcing scientists to look for alternatives or synergistic combinations with other drugs. In this work, we attempted to find a potential synergistic effect between cisplatin and cannabinoid delta-9-THC, as well as the high-THC Cannabis sativa extract, for the treatment of HT-29, HCT-116, and LS-174T colorectal cancer cell lines. However, we found that combinations of the high-THC cannabis extract with cisplatin worked antagonistically on the tested colorectal cancer cell lines. To elucidate the mechanisms of drug interactions and the distinct impacts of individual treatments, we conducted a comprehensive transcriptomic analysis of affected pathways within the colorectal cancer cell line HT-29. Our primary objective was to gain a deeper understanding of the underlying molecular mechanisms associated with each treatment modality and their potential interactions. Our findings revealed an antagonistic interaction between cisplatin and high-THC cannabis extract, which could be linked to alterations in gene transcription associated with cell death (BCL2, BAD, caspase 10), DNA repair pathways (Rad52), and cancer pathways related to drug resistance

1. Introduction

Colorectal cancer (CRC) is the third most prevalent cancer globally. It is frequently diagnosed at advanced stages, thereby constraining treatment options [1]. Even with various prevention efforts and treatments available, CRC remains deadly. There is a need for new and better ways to prevent and treat it, possibly by combining different drugs. Recent research suggests that cannabinoids could be promising in this regard [2,3,4,5,6,7,8,9,10].
In recent years, both our experimental data and data from others have demonstrated the anticancer effects of cannabinoids on CRC [11,12,13,14,15,16]. Potential mechanisms through which cannabinoids affect cancer involve the activation of apoptosis, endoplasmic reticulum (ER) stress response, reduced expression of apoptosis inhibitor survivin, and inhibition of several signalling pathways, including RAS/MAPK and PI3K/AKT [2,6,11,17]. Our research has revealed that Cannabis sativa (C. sativa) plant-derived cannabinoid cannabidiol (CBD) influences the carbohydrate metabolism of CRC cells, and when combined with intermittent serum starvation, it demonstrates a strong synergistic effect [16].
In 2007, Greenhough et al. reported that delta-9-tetrahydrocannabinol (THC) treatment in vitro induces apoptosis in adenoma cell lines. The apoptosis was facilitated by the dephosphorylation and activation of proapoptotic BAD protein, likely triggered by the inhibition of several cancer survival pathways, including RAS/MAPK, ERK1/2, and PI3K/AKT, through cannabinoid 1 (CB1) receptor activation [11]. In contrast, exposure of glioblastoma and lung carcinoma cell line to THC promoted cancer cell growth [18].
Research examining the combination of CBD with the platinum drug oxaliplatin demonstrated that incorporating CBD into the treatment plan can surmount oxaliplatin resistance. This leads to the generation of free radicals by dysfunctional mitochondria in resistant cells and, eventually, cell death [19]. Recent study has demonstrated that the generation of free radicals might be enhanced by supramolecular nanoparticles that release platinum salts in cancer cells, which potentiates the effects of treatment [20]. Several other studies showed that THC, CBD, and cannabinol (CBN) can increase the sensitivity of CRCs to chemotherapy by the downregulation of ATP-binding cassette family transporters, P-glycoprotein, and the breast cancer resistance protein (BCRP) [21], resulting in the potential chemosensitizing effect of cannabinoids [22,23,24]. These data were one of the reasons why we decided to combine a DNA-crosslinking agent cisplatin, with a selected cannabinoid extract.
Cannabis extracts contain many active ingredients in addition to cannabinoids, including terpenes and flavonoids, which possibly have a modulating, so-called entourage effect on cancer cells [25]. Research conducted on DLD-1 and HCT-116 CRC lines demonstrated a notable reduction in proliferation following exposure to high-CBD extracts derived from C. sativa plants. Furthermore, the same extract has been shown to diminish polyp formation in an azoxymethane animal model and reduce neoplastic growth in xenograft tumour models [25]. The synergistic interaction between different fractions of C. sativa extract in G0/G1 cell cycle arrest and apoptosis was also demonstrated in CRC cells [26]. In contrast, full-spectrum CBD extracts were not more effective at reducing cell viability in colorectal cancer, melanoma, and glioblastoma cell lines compared to CBD alone. Purified CBD exhibited lower IC50 concentrations than CBD alone [27]. Thus, it appears that the extract composition and concentration of other active ingredients could be the modulating factors of the anti-cancer effect of cannabinoids [28].
The cannabis plant contains a variety of terpenes and flavonoids, which are biologically active compounds that may also hold potential for cancer treatment [29,30]. There are 200 terpenes found in C. sativa plants [31]. Here, we will review terpenes that were relevant to our study.
Myrcene, a terpene present in cannabis plant, demonstrated carcinogenic properties, leading to kidney and liver cancer in animal models [32] and in human cells [33]. However, it also demonstrated cytotoxic effects on various cancer cell lines [31,34].
Another terpene that appears in cannabis is pinene. Pinene, another terpene found in cannabis, has demonstrated the ability to decrease cell viability, trigger apoptosis, and prompt cell cycle arrest in various cancer cell lines [35,36,37,38,39,40,41]. Moreover, it can act synergistically with paclitaxel in tested lung cancer models [39]. In vivo animal models showed a decreased number of tumours and their growth under pinene treatment [42]. These data could also support the notion that whole-flower cannabis extracts rich in terpenes and perhaps other active ingredients are more potent against cancer than purified cannabinoids [43].
Cisplatin has a limited therapeutic window and causes numerous adverse effects, and cancer cells are often developing resistance to it [44,45]. To avoid the development of drug resistance, cisplatin is often employed in combination with other chemotherapy agents [46]. The formation of DNA crosslinks triggers the activation of cell cycle checkpoints. Cisplatin creates DNA crosslinks, activating cell cycle checkpoints, causing temporary arrest in the S phase and more pronounced G2/M arrest. Additionally, cisplatin activates ATM and ATR, leading to the phosphorylation of the p53 protein. ATR activation induced by cisplatin results in the upregulation of CHK1 and CHK2, as well as various components of MAPK pathway, affecting the proliferation, differentiation, and survival of cancer cells [47], as well as apoptosis [48].
Based on the extensive literature review, there is compelling evidence to warrant investigation into the efficacy of C. sativa extracts containing various terpenoid profiles. This exploration aims to determine whether specific combinations of cannabinoids with terpenoids could yield superior benefits in treating CRC cell lines compared to cannabinoids alone. Therefore, evaluating selected cannabinoid extracts alongside conventional chemotherapy drugs, such as cisplatin, holds promise. This approach is particularly advantageous given the prevalence of cancer patients using cannabis extracts for alleviating cancer-related symptoms. Here, we analyzed steady-state mRNA levels in the HT-29 CRC cell line exposed to cisplatin, high-THC cannabinoid extract, or a combination of both treatments.

Table 1

https://preview.redd.it/f3jwd2srldxc1.jpg?width=954&format=pjpg&auto=webp&s=eeb878540bbf7db74573a9b5f6f3365264f368be

Original Source

submitted by NeuronsToNirvana to NeuronsToNirvana [link] [comments]


2024.04.28 09:36 Majestic-Ad6885 Heart, High Blood Pressure, Edema Questions

Make, Age 57, Height 6ft tall, weight 270lbs. I have been diagnosed with high blood pressure, edema and enlargement of the heart. I was prescribed a fixed-dose combination of losartan and hydrochlorothiazide (hyzaar) titrated to 50/12.5. My questions are several fold: 1. is furosemide ever indicated/prescribed in combination with hyzaar for edema? I think I gathered that this combination could be contraindicated and closely monitored for changes in Blood pressure and kidney function. Having said that, is there a medical case for these 3 in combination worth pursuing with my doctor? If not, please explain 2. Carvedilol. Is it ever prescribed with Hyzaar? Or does the chance of fluid retention make it not worth the risk even if there could be slightly improved blood pressure numbers? Thanks in advance for any response. I'm trying to be active in my healthcare and am trying to make sense of everything.
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2024.04.27 03:23 OkAfternoon6013 Why I'm quitting all meds after 20 years.

I've decided to taper off and quit my medications after being treated for hypertension for the past twenty years. While this may sound crazy, please hear me out.
Im a 50 yr old male, 6'0 and 168 lbs. I don't smoke, I recently gave up alcohol, and I eat a healthy diet and get a good amount of exercise.
I currently take Valsartan, 360 mg, which is the max dose. I also have a prescription for Amlodipine 10 mg, but Amlodipine makes my feet and legs swell, among other unpleasant side effects, and I don't like how I feel on it. Other meds I've tried are Losartan and Lisinopril, and Hydrochlorothiazide. Losartan worked for awhile and then it stopped. Lisinopril gave me a tickle cough that kept me awake at night. And the water pill wrecked my libido.
So why am I quitting bp meds? I'm quitting because I have come to the realization that a lowered bp through medication is not actually fixing anything. Hypertension is a symptom, not the disease. By lowering it with pharmaceuticals, we're not actually improving our health...whatever is causing our bp to rise is still going on inside us. I've also learned that people who treat their hypertension with meds still have heart attacks, strokes, and get heart disease. And by lowering their blood pressure with medication, most people become complacent, thinking that they've got their problem under control.
I've also learned that there are plenty of obese people with diabetes who never exercise and eat junk food all day, and they have perfect blood pressure. How can this be? My wife isn't diabetic or obese, but she doesn't eat that well and rarely exercises, and her bp is 95/50. Some people's genetics are such that their blood pressure stays low, regardless of their lifestyle.
Another thing I found interesting is how much lower the threshold for blood pressure treatment has become. it used to be considered normal to be 140/90, but Big Pharma can't make money off of normal.
And lastly, blood pressure is just one risk factor for heart disease, and the only one I have. I plan to eat right, stay fit, sleep well, avoid alcohol, get plenty of sunshine, and manage stress as best I can. I will continue to search for the root cause of my hypertension, as well as natural ways to normalize it.
submitted by OkAfternoon6013 to hypertension [link] [comments]


2024.04.26 19:32 megameg2223 feel like I was misled into getting silver fillings when I actually could have gotten composite. now I have a lot of sensitivity issues with them. what are my best options for resolution?

I visited a new dentist for the first time in a few years after getting a job with dental insurance. I discovered I had a filling that had fallen out and another tooth that had a cavity needing to be drilled/filled.
My issue is that on the day of my appt to fix the fillings, the dentist led me to believe my insurance only covered silver fillings. The conversation was almost word for word this:
She asked, "you have Delta, right?". I said, "yeah". She said, "Delta covers silver, you okay with silver?". I said, "I don't know, is there a filling type that is recommended over the others" (I was curious about paying out of pocket for the better type of fillings). She sounded irritated and said something like she was only asking because my other fillings are white but "silver lasts longer". I said, "oh, okay, I guess if that's what my insurance covers then". She proceeded to fill my teeth with silver, which I've never had in my mouth before.
Ever since the appointment (about two weeks now) I have been having pain and extreme sensitivity to hot and cold, and it's not getting better. I'm frustrated because I never experienced this kind of pain with any of my composite fillings. The dentist never said a word to me about this being a possible issue, otherwise, I would have not gone forward with silver fillings. I am autistic and have sensory issues so it's been really challenging. Though I am aware sensitivity and pain may eventually subside after several weeks of recovery, I'm still concerned about continued sensitivity to hot and cold in these teeth due to the filling type.
So I called my insurance today to see what my out-of-pocket expenses look like if this ever happens again and I get composite instead of silver in the future, and they informed me that there is no downgrade to silver on my plan and that the dentist could have used composite and it would have cost the same exact amount. The representative was surprised the dentist would have even said what she did about my coverage just based off hearing "Delta", since they have so many different policies and coverages available, it's impossible to know without knowing which specific Delta plan I have.
I'm really upset because I would definitely rather have had the composites, I don't like how the silver looks in my mouth and I can't stand the sensitivity and pain. I am also upset because I feel like my ignorance was taken advantage of (I'm not sure if that was the intention, but the experience felt really off compared to other dental visits I've had in the past, and the dentist felt pushy). I trusted the professional to fully inform me of my options and it doesn't feel like that's what happened here.
I guess my question is what do you think is the best course of action for this situation? Should I proceed with trying to get the silver fillings replaced with white composite? Is getting silver fillings replaced with composite a difficult process and are there any risks involved? Would it be better to leave the teeth alone and deal with the recovery process and hope all the sensitivity eventually goes away?
Unfortunately, my insurance company said to have it covered by them, the swap needs to happen with the same dentist, who I don't trust anymore. Otherwise, I need to file a grievance which could take up to 60 days to be processed. Looking back at the conversation, nothing the dentist said was completely untrue, she just wasn't giving me full information, so I'm not sure what my chances of getting a grievance approved even is at this point.
Not sure if it's relevant, but I am 32, autistic, and have type 2 diabetes and high blood pressure (I take metformin and losartan as treatment). edit: I do not drink and I do not smoke
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2024.04.26 00:56 Isaiah_6_8 Need recommendations for transporting vehicle from LV to HI

update: decided on Hawaii Car Transport. It was the most convenient "one-stop" full service. The other option was to schedule separate services to tow the vehicle from LV address to Long Beach CA. Surprisingly, the cost difference to coordinate all this (compared to doing the full service with HCT) was, in my opinion, insignificant.
I've got family finally moving back home to Oahu. They're considering shipping their vehicle (instead of selling there, buying here). Anyone have recommendations for a full service transport company that'll pick up the vehicle at their LV address? We can pick up at the Oahu port.
I've done the transport from HI to LV, but never the other way around. I assume the process is the same.
Thanks for the recommendations
submitted by Isaiah_6_8 to Hawaii [link] [comments]


2024.04.24 06:54 Alternative_Squash13 Low MCV, should I be concerned?

I (31F) recently got lab work done and got my blood test results back. I have been feeling dizzy, weak, and tired after any form of exercise. I got tested because my therapist suggested I get tested due to my memory problems. I got my test results back for my blood count. I noticed something when comparing my test results from last year. My MCV is below what is considered "normal". I am not sure if this is what is causing my symptoms. I have a doctor's appointment until next month so I thought I would try to figure out what my results meant while I wait. Last year my MCV level was 78.2 and this year it was 79.4. My blood sugar also got tested and that was normal. Last year when my MCV was what is stated in the table below my doctor said that everything was normal. Should I be concerned?

Thank you in advance for your responses.

Complete Blood Count (CBC)
CBC Test 2023 2024
WBC's AUTO 6x1000/mcL 5.6x1000/mcL
RBC, AUTO 4.91Mill/mcL 5.09Mill/mcL
HGB 13.2g/dL 12.9g/dL
HCT, AUTO 38.4% 40.4%
MCV 78.2fL
79.4fL MCH26.9pg/cell25.3pg/cell MCHC 34.4g/dL31.9g/dL RDW,BLOOD13.4%14.5% PLATELETS, AUTOMATED COUNT213x1000/mcL201x1000/mcL

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2024.04.22 03:11 OkLiterature4724 Recovery from low potassium after stopping diuretic?

I've been taking 12.5mg of Hydrochlorothiazide (diuretic) since August 2023, with 100mg of Losartan. My doctor switched me to 40mg of Olmesartan in December 2023 because my blood pressure was still higher than he liked it to be. Since then, along with losing weight and improving my diet, my blood pressure has been much better.
However, I had an ER visit last month because I had a fast heartbeat and my body felt "heavy." My EKG was fine other than the fast heart rate, but I was told that my potassium was low. 3.3 mmol/L to be exact, compared to the 3.7 it was when I got blood work done in December. All other blood work was fine, according to the ER people. Around this time, I was also noticing chest discomfort and lightheadedness if I sweat too much. I also started to have irregular heartbeats hours after working out, but usually not during, which I think is odd.
My doctor (and I) came to the conclusion the other day that taking Hydrochlorothiazide for an extended period of time, even though I was on the lowest dose, was causing my potassium levels to drop. I also had another EKG done, which I was told was fine. He has taken me off of Hydrochlorothiazide, so I now just take the Olmesartan 40mg.
I was an idiot and completely forgot to ask him how long would it take for my potassium levels to go back up, or if they even will on their own. Sure, not taking the diuretic anymore will stop it from getting worse, but will it also allow my potassium levels to go back up on their own? Or will I have to do some additional potassium treatment to get them back normal again? I definitely did not have potassium issues before I started taking it.
submitted by OkLiterature4724 to DiagnoseMe [link] [comments]


2024.04.13 19:48 Admiraloftittycity 27M Unexplained Swelling in hands and feet

27 male, 6'1" ~350lbs, diagnosed hypertensive and pre-diabetic. Managed with Losartan, hydrochlorothiazide, Metformin, and fish oil supplements.
This started like a year ago maybe? Not sure. But whenever my hands or feet experience mild trauma they get super itchy and when I itch them they swell out of control. The two most recent examples are
1) went to a wedding, wore super uncomfortable dress shoes that squeezed my toes together and hurt my soles, once I took my shoes and socks off at the end of the day my feet got super itchy. Being a dummy I itched them like crazy for any amount of relief. Within an hour or two they began swelling and when I woke up the next day they were so painfully swollen I had trouble walking. Treated pain with ibuprofen, swelling went down over the course of the day.
2) yesterday i went go-karting for the day, and at the end of the day it felt like my tendons in my fingers felt like they were on fire. Within an hour or so my fingers (especially the space between them) and my hands became super itchy. Again being a dummy I vigorously scratched and itched and rubbed my hands against things to make the itchiness stop only to wake up to hands swollen to the point I can hardly touch my thumb and pinky tips together. Pictured
I'm looking to identify the cause so I can potentially treat/avoid it. Thanks in advance for any help.
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2024.04.09 20:43 Rielo Are 25 mg losartan as effective effective as 50?

https://www.ahajournals.org/doi/full/10.1161/01.HYP.26.1.112
Losartan at 25 and 50 mg plus HCTZ produced marked reductions (−10 and −12.6 mm Hg) in SiSBP compared with the control group; these changes were both clinically and statistically significant (P≤.01).
It looks like there is no need for the higher dose. What do you think?
submitted by Rielo to hypertension [link] [comments]


2024.04.01 07:49 Bossie81 $ATRA Won't be cheap for long

$ATRA Won't be cheap for long
Update on earning

Cash runway into 2027! Rare for a microcap biotech. - cash $104M + - 20M milestone for positive BLA meeting - 20M milestone for BLA acceptance - 60M milestones for approval - then royalties of 500M in peak sales - CAR-T pipeline progressing in both oncology and autoimmune indications Current market cap 70M Current enterprise value 17M

Tabelecleucel (tab-cel® or Ebvallo) for Post-Transplant Lymphoproliferative Disease (PTLD)
  • Atara recently held a positive pre-BLA meeting with the U.S. Food and Drug Administration (FDA) that supports its plan to submit the tab-cel relapsed or refractory Epstein-Barr virus positive post-transplant lymphoproliferative disease (EBV+ PTLD) Biologics License Application (BLA) in Q2 2024
  • Data from the pivotal Phase 3 ALLELE study of tab-cel were published in The Lancet Oncology and showed a significant 51.2% objective response rate (ORR) and 23.0-month median duration of response in relapsed or refractory EBV+ PTLD subjects. Tab-cel was well tolerated with no events of graft-versus-host disease related to tab-cel
  • Positive new data presented at the 2023 ESMO-IO meeting from the actively enrolling, multicohort Phase 2 EBVision trial with a pooled analysis demonstrated a 77.8% ORR in 18 central nervous system (CNS) EBV+ PTLD subjects including front line EBV+ PTLD
  • Atara and Pierre Fabre Laboratories closed the expanded global partnership in December 2023 for the development, manufacturing, and commercialization rights of tab-cel in the United States and all remaining markets
  • Atara received approximately $27 million in cash upfront at the closing of the deal. Under the agreement, Atara has the potential to receive up to $640 million in additional payments and significant double-digit tiered royalties on net sales, including up to $100 million in potential regulatory milestones through BLA approval
    • Atara expects to receive $20 million of these regulatory milestones in April based on the recent positive pre-BLA meeting, another $20 million in connection with BLA acceptance, and the remaining $60 million in potential regulatory milestones in connection with BLA approval
  • In addition, Pierre Fabre Laboratories will reimburse Atara for tab-cel regulatory and development costs through BLA approval, and purchase tab-cel inventory manufactured through BLA transfer
ATA3219: CD19 Program in Lupus Nephritis
  • Investigational New Drug (IND) application cleared for the use of ATA3219 as a monotherapy for the treatment of systemic lupus erythematosus (SLE) with kidney involvement (lupus nephritis [LN])
  • Atara plans to initiate a Phase 1 LN study in H2 2024 with initial clinical data anticipated H1 2025
  • The Phase 1 open-label, dose-escalation study is designed to evaluate safety, preliminary efficacy, pharmacokinetics, and biomarkers of a single dose of ATA3219 administered to LN subjects refractory to one or more lines of treatment. Subjects will receive lymphodepletion (LD) treatment followed by ATA3219 at a dose of 40, 80, or 160 x 106 CAR+ T cells. Each dose level is designed to enroll 3-6 patients
  • In vitro data demonstrated the CD19 antigen-specific functional activity of ATA3219 and CAR-mediated activity against B cells from SLE patients. ATA3219 led to near-complete CD19-specific B-cell depletion compared to controls. These preclinical data were submitted as part of a late-breaking abstract which was accepted for poster presentation at the upcoming International Society for Cell & Gene Therapy meeting held May 29-June 1, 2024
ATA3219: CD19 Program in Non-Hodgkin’s Lymphoma (NHL)
  • Atara initiated enrollment of a multi-center, Phase 1 open-label, dose-escalation clinical trial of ATA3219 in NHL, including large B-cell lymphomas, follicular lymphoma, and mantle cell lymphoma, with initial clinical data anticipated in Q4 2024
  • Study designed to evaluate safety, preliminary efficacy, pharmacokinetics, and biomarkers. Subjects will receive LD treatment followed by ATA3219 at a dose of 40, 80, 240, or 480 x 106 CAR+ T cells. Each dose level is designed to enroll 3-6 patients
  • Preclinical data previously presented demonstrated superior in vivo persistence and CD19-specific anti-tumor efficacy compared to an autologous CD19 CAR T benchmark with no observed toxicity or alloreactivity
ATA3431: CD19/CD20 Program for B-Cell Malignancies
  • Preclinical data presented at ASH 2023 demonstrated early evidence of potent antitumor activity, long-term persistence, and superior tumor growth inhibition compared to an autologous CD19/CD20 CAR T benchmark
  • Dual CD19 and CD20 targeting designed to address CD19 escape and tumor variability and may provide additional efficacy in lymphoma
  • Atara is progressing toward an IND submission in 2025
https://preview.redd.it/h99q9wm93trc1.png?width=1362&format=png&auto=webp&s=1f85ee7899aac83e1dfd3d21600b416175b852b6
  • Chief Medical Officer exit, but rehired as a consultant
    • Pre-planned strategy
      • This I find remarkable. Bio without CMD, anticipate a BO?
  • 25%+ Reduction in workforce
    • Cost cutting in Bios is commonplace, but in combination with other signals. BO smell.
  • Piere Fabre expanded partnership
    • 24+ million payment has been received upfront from Pierre Farbe.
    • Earning calls will be excellent
      • In case of a BO, the company hands over a healthy balance sheet
  • 27 Million shares being 'offered' but no disclosure, as this is through a broker.
  • Tutes
    • JP Morgan, 2,2 million shares (Dec 2023)
    • Eco R1 10 million shares (Dec 2023)
    • Blackrock 500k (Jan)
    • Statestreet 2 million shares (Jan)
      • Positions have been reduced/exited too by some other less significant Tutes
  • Atara is first company to obtain approval for allogenic T-cell Immunotheraphy
    • Advanced pipeline for multiple indications
      • What BP is hunting for!
  • Recent
    • ATARA a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, and Pierre Fabre Laboratories, a global player in oncology and responsible for worldwide commercialization of tabelecleucel (tab-cel® or EBVALLO™), today announced that data from the pivotal Phase 3 ALLELE study of tab-cel, approved in the European Union in adults and children two years of age and older with relapsed or refractory Epstein-Barr virus positive post-transplant lymphoproliferative disease (EBV+ PTLD) following solid organ transplant (SOT) or hematopoietic cell transplant (HCT), were published for the first time online in The Lancet Oncology.
  • NOTES
    • BO or not. The pipeline is amazing. The partnerships are solid. Even without these signals I would be invested.


submitted by Bossie81 to pennystocks [link] [comments]


2024.03.25 01:53 rossth760 Anion Gap- massively high..

45f obese 272, smoker, no alcohol
Meds: spironolactone, losartan, Pravastatin, synthroid, vitamin d, folic acid, desvenlafaxine.
Seeing hematologist due to leukocytosis and one of the results over the weekend came back obscenely high : Anion gap 43, it shows that the high normal is max of 12.
All other labs in the panel were normal.(albumin, chloride, sodium, potassium, Co2, etc)
Not having any weird symptoms.
Have been losing weight- 26lbs since Dec 2, 2023. Balances diet- no keto etc.
Other tests run were cbc- elevated wbc 14.7 and hct 47.4%, everything else was normal. Waiting on EPO and I think some others that don’t show yet in portal.
Any insight would be awesome!
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2024.03.24 06:56 Several_Cheek5162 BP Medications

Was diagnosed with high BP at urgent care last year couldn’t get into see my GP for several months ended up finding a new GP and a much smaller practices that doesn’t take on very many patients (essentially friends of friends only).
Urgent care and previous GP had me on Lisinopril which managed my BP great! Unfortunately I developed that cough related to ACE inhibitors.
New GP then swapped me to Losartan which doesn’t seem to be doing much (Still in the mid 140s over mid 90s) so this week she added in Hydrochlorothiazide to the mix.
How long does it take for the Hydrochlorothiazide to start changing my BP? Days? Weeks?
Some background; I’ve been overweight since midway through Covid (257lbs 5’10) and have reduced my weight significantly (224 as of this morning). And I’m a bit bummed that it isn’t having more of an effect on my high BP.
Additionally, I think my caffeine intake may be too high? I have about 10 to 13 glasses of unsweetened black ice tea per day… plus a reign energy drink.
submitted by Several_Cheek5162 to bloodpressure [link] [comments]


2024.03.22 04:30 icropdustthemedroom SEVERE (!!!) uncontrollable GERD. PCP put in for GI consult, GI won't even let me SCHEDULE with them for two months...

Hi all,
ER RN here, 35M caucasian, 6'1", 185 lbs. I've been dealing with GERD for about ~7 years now intermittently, but this year it's got much worse. I have a family pre-disposition I think, my mom has had it for like 20 years or something. I think I got it from being a very high-stress person and previously I used to drink too much caffeine + coke zero + spicy food...I cut all this out a month ago entirely (I had been decreasing all of these for a while before that).
I have been taking PPIs intermittently (e.g. 1-2 weeks at a time, maybe once ever 4 months) for probably 5 years and pepcid complete intermittently for about 5 years, but recently this isn't doing it. Only other med is losartan-hydrochlorothiazide for mild HTN. No other relevant PMH.
My PCP recently started me on 40 mg PPI (omeprazole) 2x per day (80 mg total per day) x 6-8 weeks. I'm about 10 days in and tonight I have the worst heartburn I've had in the last year at least. Today I have taken my 80 mg PPI + 2x pepcid complete tablets + probably 20 mL of maalox + no caffeine or spicy or zero-cal soda or anything else I know to be exacerbating for the last week at least. STILL have 8/10 heartburn right now. I'm honestly probably a bit of a hypochondriac from all I know and I worry about something like Barrett's esophagus; I have also been under a lot of stress recently. Had H. pylori testing approx 18 months ago and it was negative. My PCP put in for a GI consult about 10 days ago and I called a week ago to schedule and they literally were like "we'll call you when we're ready to schedule you...probably in like 2 months or so."
What do I do? I honestly kinda want to go to the ED and request an upper endoscopy or something, but I'm afraid they're just going to tell me they can't do it, that I need an outpatient GI consult for that, and I'll be right back where I am now with only a $1000 ED bill to show for it. I don't even wanna eat tonight it's so bad.
What would you do?
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http://rodzice.org/