Diagram of muscle cell

Support for sufferers of Pelvic Floor Dysfunction.

2014.03.30 11:14 mundabit Support for sufferers of Pelvic Floor Dysfunction.

This is a subreddit to raise awareness and offer support for people with PFD. Pelvic floor dysfunction refers to a wide range of issues that occur when muscles of the pelvic floor are weak, tight, or there is an impairment of the muscle, nerves or joints. Tissues surrounding the pelvic organs may have increased or decreased sensitivity and function resulting in pelvic pain.
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2014.11.07 01:56 Calcium

The Calcium Reddit
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2016.12.06 03:15 Draw it to Know it

The official community for Draw it to Know it. Drawittoknowit.com
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2024.05.15 18:42 Suspicious_Basket799 Using the sensor with Raspberry Pi 4

Hello, is it possible to use the MyoWare Muscle Sensor 2.0 with Raspberry Pi 4? As far as I know, you need an ADC as Raspberry Pi doesn't have any analog pins. I have PCF8591 YL-40 AD DA module. How would I go about connecting the sensor to Raspberry Pi in terms of circuit diagram and software/libraries?
submitted by Suspicious_Basket799 to MyoWare [link] [comments]


2024.05.15 18:01 fifi_edits 6 Delicious Keto Broccoli Recipes

Broccoli is a versatile, nutrient-packed vegetable and a delicious low-carb addition to any keto diet.

Health benefits of broccoli

Have you noticed that nutritionists and health experts constantly praise broccoli? This low-carb superfood is packed with essential vitamins, minerals, and other nutrients critical for promoting a healthy body and enhancing overall wellness.
1. Nutrient-dense superfood
Broccoli is abundant with nutrients, including vitamins C, E, and K, beta-carotene, calcium, potassium, iron, antioxidants, and other health-promoting bioactive compounds.
Research published in Frontiers in Pharmacology states that eating more cruciferous vegetables, such as broccoli, may reduce the risk of developing certain diseases, including cardiometabolic, neurological, and musculoskeletal conditions. In addition, broccoli's high fiber and antioxidant content support the body's natural detoxification processes and help protect against oxidative stress.

2. Supports digestive health

Fiber, the non-digestible cell wall found in plant foods, plays a vital role in promoting healthy digestion. Regular fiber intake enhances the protective barrier in the digestive system and helps regulate bowel movements. Broccoli is an excellent source of dietary fiber and, as a result, promotes a healthy digestive tract. Incorporating more broccoli into your diet can help remove toxins from the digestive tract and support the growth of beneficial gut microbes by providing a fuel source for probiotic bacteria.
3. Strengthens immune defenses
Vitamin C is a powerful antioxidant that helps strengthen the immune system, heal wounds, and protect the body from harmful pathogens and diseases. According to data from the U.S. Department of Agriculture (USDA), 3.5 ounces (100 grams) of raw broccoli contains 90 milligrams of vitamin C. This is nearly double the amount of an orange. In addition, broccoli is a rich source of sulforaphane, a phytonutrient that has been shown to drastically improve immune system functions, according to research published in Molecules.

4. Potential anti-cancer properties

Cruciferous vegetables like broccoli are unique for their exceptionally high content of glucosinolates. These compounds, when eaten, transform into beneficial bioactive substances such as sulforaphane, which exhibits promising anti-cancer properties.
"Broccoli sprouts have the highest concentration of sulforaphane compared to any other food on the planet. Sulforaphane has been extensively studied for its potential anti-inflammatory, antioxidant, and even anti-cancer properties," says Dr. Berg.
According to research published in Frontiers in Oncology, sulforaphane can target and inhibit cancer stem cells across various cancers, including leukemia, lung, breast, prostate, colon, gastric, and pancreatic cancer. By inhibiting cancer stem cells, a type of cancer cell responsible for tumor initiation and growth, sulforaphane may help prevent the development and spread of cancer. The authors also highlight the potential of combining sulforaphane with other natural compounds or chemotherapeutic drugs to enhance and amplify their anti-cancer effects.

5. Promotes strong bones

Broccoli is an excellent source of calcium and vitamin K, essential for maintaining strong bones and lowering the risk of osteoporosis. Additionally, broccoli's high vitamin C content helps promote the production of collagen peptides critical for joint, muscle, and bone health.

6. Aids in weight management

Broccoli is low in calories and carbohydrates, high in fiber, and scores just 15 on the glycemic index, indicating that it doesn’t significantly impact blood sugar or insulin levels. This makes broccoli a great addition to a low-carb diet and may help promote weight loss by improving satiety and reducing glucose-related cravings after meals.

7. Anti-inflammatory effects

According to evidence published in Antioxidants, broccoli’s high concentrations of sulforaphane, indole-3-carbinol, and diindolylmethane can help mediate inflammation. The authors summarize, "Sulforaphane may help reduce inflammation by inhibiting the activity of certain enzymes that promote inflammation. It has also been found to stimulate the production of antioxidant enzymes that protect cells from inflammation-related damage."
Similar immune system regulatory effects were observed with indole-3-carbinol and diindolylmethane.

6 must-try low-carb broccoli recipes

Whether you're in the mood for a comforting side dish or a savory appetizer. Here are six low-carb broccoli recipes to ensure you'll never grow tired of incorporating broccoli into your meal plan.
1. Broccoli Fritters
These tasty broccoli fritters are a perfect way to provide a delicious savory appetizer while sticking to a low-carb keto diet. This recipe combines broccoli with curry powder, eggs, and coconut flour for a satisfying and nutritious meal.
2. Keto Cheese & Broccoli Salad
This refreshing cheese and broccoli salad combines fresh broccoli florets, cheddar cheese, crispy bacon, and your preferred dressing. Add parmesan cheese for an extra boost of flavor and healthy fats! It's an excellent option for those looking for a keto broccoli recipe that's delicious and easy to prepare.
3. Keto Broccoli Cheddar Casserole
Indulge in this broccoli cheddar casserole featuring broccoli and cheese served in a creamy sauce. The recipe combines fresh or frozen broccoli, cream cheese, cheddar cheese, and a hint of garlic powder for a comforting and satisfying low-carb dish.
4. Keto Grilled Summer Vegetables
Fire up the grill and enjoy a colorful array of summer vegetables, including roasted broccoli. This keto-friendly broccoli recipe is enhanced with grill seasoning, olive oil, and onions for a burst of flavor. Perfect for backyard barbecues or weeknight dinners. Try experimenting with alternate seasonings such as Cajun, Za'atar, or Italian seasoning for a different flavor profile.
5. Keto Broccoli Cheese Bites
Another delicious variation of broccoli cheese bites, this recipe combines fresh broccoli, cheddar cheese, and scallions for a savory and satisfying side dish. Perfect for parties or as a quick and easy low-carb appetizer.
6. Keto Broccoli and Cauliflower Salad with Bacon
This flavorful salad is made with steamed broccoli, cauliflower, and crispy bacon crumbles tossed in a tangy dressing. It's a great way to enjoy broccoli and cheese on a keto diet while incorporating additional low-carb vegetables.
For even more delicious options, here are some other low-carb broccoli recipes to choose from:
Potential downsides of broccoli
While broccoli is generally safe and well tolerated by most people, it does have some potential downsides.
The way broccoli is prepared can significantly impact its nutritional value. Certain cooking methods, such as boiling, microwaving, and stir-frying, can substantially decrease beneficial nutrients and glucosinolates.
A study published by the Journal of Zhejiang University Science B investigated how cooking affects broccoli’s nutritional value.
The authors summarized, "All cooking treatments, except steaming, caused significant losses of chlorophyll, vitamin C, and glucosinolates. Steaming appears to be the best method for nutrient retention in cooked broccoli."
In addition, while cruciferous vegetables such as broccoli are nutrient-dense, consuming excessive amounts of dietary fiber can lead to adverse effects.
Contrary to popular belief, fiber can trigger gas and abdominal pain and may worsen constipation, especially in particularly sensitive individuals with digestive conditions.
In addition, broccoli is a rich source of vitamin K, which plays a crucial role in blood clotting. Consuming large amounts of broccoli may increase the risk of excessive bleeding in individuals with blood clotting disorders and those taking certain blood-thinning medications.
If you are taking blood thinners, it’s recommended that you consult a healthcare provider to discuss appropriate dietary intake.
submitted by fifi_edits to DrEricBergDC [link] [comments]


2024.05.15 18:01 myzozofit FIT Tip of the Week: Muscle vs Fat - Which Weighs More?

FIT Tip of the Week: Muscle vs Fat - Which Weighs More?
It is a common misconception that muscle weighs more than fat. Many people believe that if they gain muscle mass through strength training and build up their muscles, they will gain weight on the scale. However, this is not entirely accurate. Understanding the difference between muscle vs. fat weight has important implications for fitness and health.
Building muscle mass increases strength for physical performance and daily activity. It also boosts metabolism because muscle tissue is metabolically active, burning calories even at rest.

The Difference Between Muscle vs. Fat Weight

Body weight reflects a combination of muscle weight, fat weight and other factors, but do muscles or fat weigh more? Considering the role of each can help you dispel some common misconceptions.

Understanding Muscle Weight

Muscle weight refers to the total mass of skeletal muscle tissue in the body. Skeletal muscles are the voluntary muscles that attach to bones by tendons and that control bodily movements and posture.
The weight of muscle comes from its main components of water, protein and glycogen. Water accounts for about 75% of muscle's weight. The protein actin and myosin make up about 20% and provide the fibers that enable muscles to contract. Glycogen, the stored form of glucose, accounts for 5% and provides an energy source for muscle activity.
Skeletal muscles play several crucial roles in the body. First, they allow for a wide range of movements such as walking, lifting and sports activities by transforming chemical energy into mechanical energy and generating force. They also help maintain posture and provide joint support and protection.
Additionally, muscle plays a major role in metabolic function. Pound for pound, skeletal muscle burns more calories than fat tissue, so the greater someone's muscle mass, the higher their resting metabolism. Resistance training to build muscle can help increase resting metabolic rate. This is because the protein turnover and repair of muscle tissue after exercise requires energy expenditure.
Having more muscle vs. fat weight also confers several health and performance benefits. Greater muscle strength from resistance training enhances athletic performance, speed and power. It also enables a higher level of daily physical activity and helps prevent injury by protecting joints. Lastly, the increase in muscle mass significantly improves body composition. Since muscle takes up less space than fat, it creates a tighter, leaner physique at the same body weight.

Considering Fat Weight

Fat weight refers to the total mass of adipose tissue in the body. Adipose tissue consists of adipocytes, or fat cells, that store energy in the form of lipids.
The main components of fat tissue are triglycerides, which make up about 90% of the weight of fat. The rest consists of water, cholesterol, fatty acids, glucose and other substances. Unlike muscle, fat does not contract and its main functions are to insulate the body, cushion internal organs and store energy in the form of fat.
There are several types of fat in the body. Subcutaneous fat sits just under the skin while visceral fat surrounds internal organs. Intramuscular fat accumulates in skeletal muscle. Brown fat contains many mitochondria that can generate heat and burn calories. White fat stores and releases energy. Having some fat is essential for health but excess amounts, especially visceral fat, can increase disease risk.

The Impact of Muscle vs. Fat Weight on Body Shape

While muscle and fat both contribute to overall body weight, they have very distinct effects on your physical appearance and health. This is because muscle is densely packed while fat is less compact. As a result, gaining muscle mass can actually lead to a tighter, leaner physique. On the flip side, losing weight does not always equate to a fitter, healthier body.
Though a pound of muscle weighs the same as a pound of fat, it takes up significantly less space. Muscle fibers are neatly bundled in repeating patterns that pack tightly together. Fat cells have a more open, random structure with gaps between cells. So a person with a higher ratio of muscle to fat will have a more firm, toned look than someone with a higher percentage of body fat.
This is why the scale doesn’t give the full picture of your body composition and fitness level. Two people can weigh the same amount but look vastly different based on their muscle-to-fat ratio. Judging by appearance and ability to move well, lift heavy things and metabolize food efficiently is more telling than a lower number on the scale. The goal should be optimizing health and functionality by maximizing metabolism-boosting muscle while keeping fat within a healthy range.
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submitted by myzozofit to myzozofit [link] [comments]


2024.05.15 17:29 NoGoats_NoGlory Horses on the Trail - Please slow down and try to look human!

You all, horses are 1,000 pounds of muscle controlled by a handful of working brain cells. They are prey animals, and prey animals do their freakout first and their thinking later. The rider has no control over this.
You guys on mountain bikes - please know that when you're hunched over on a bike with a helmet on, to a horse, YOU DON'T LOOK LIKE A HUMAN. You look like a monster. What kind of monster? The kind that eats horses!
When you see a horse and rider coming, please stop and PUT A FOOT DOWN and say "hello" or something. Now my horse's limited intelligence will recognize you as a person. You don't have to get off completely, you don't have to move off the trail, just give me space to pass and say something! Coming up behind us on the downhill? I can't see you coming but my horse can, and he is going to kick you if you pass too close! Please start hollering to me as soon as you're within shouting distance. I will move my beast off the trail and let you pass.
99% of the MTB riders I encounter are wonderful, but I had one go flying past me out in the open yesterday that panicked my horse. My horse is old and experienced, he's seen a thousand bikes, but this one was going so fast that his flight instinct kicked in and he spooked. Karma got the guy a minute later though - he was going too fast to make the first switchback below us and crashed into the bushes. Slow down folks!
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2024.05.15 17:11 No-Physics7479 Basic Electronic Components: English Translation

1. Resistors:

Function: Limits current, divides current, creates voltage drops, adjusts voltage.
Variable Parameter: Resistance (R) - measured in Ohms (Ω).
Significance: The higher the resistance value, the lower the current through it, and vice versa.
Construction: A resistive core (carbon, metal, ceramic, etc.) coated with an insulating layer.
Operating Principle: Based on the collision of electrons with atoms in the resistive core, reducing the energy of the electrons and converting it into heat energy.
Applications: Widely used in electronic circuits, from simple to complex circuits. For example: limiting current through LEDs, dividing current in amplifier circuits, creating voltage drops for voltage regulator circuits, adjusting voltage in filter circuits...

2. Capacitors:

Function: Stores electrical energy, filters signals, blocks AC current, passes DC current.
Variable Parameter: Capacitance (C) - measured in Farads (F).
Significance: The higher the capacitance value, the greater the ability to store electrical energy, and vice versa.
Construction: Two parallel metal plates separated by an insulating dielectric (paper, ceramic, mica...).
Operating Principle: When a voltage is applied, an electric field is created between the capacitor plates, charging the capacitor plates. When the power is turned off, the electric field remains and keeps the capacitor plates charged.
Applications: Very diverse in electronic circuits, from power supply filtering to oscillator circuits. For example: filtering power for electronic circuits, generating pulses for oscillator circuits, blocking noise signals...

3. Inductors:

Function: Stores electrical energy in the form of a magnetic field, resists sudden changes in current, creates time delays.
Variable Parameter: Inductance (L) - measured in Henrys (H).
Significance: The higher the inductance value, the greater the resistance to sudden changes in current, and vice versa.
Construction: A coil of conductive wire wrapped around a core (plastic, iron...).
Operating Principle: When current flows through the inductor, a magnetic field is created around it. When the current changes, the magnetic field also changes, generating an induced voltage in the opposite direction of the current, counteracting the sudden change in current.
Applications: Common in power supply filtering, resonant circuits, transformer circuits... For example: filtering power for electronic circuits, generating pulses for oscillator circuits, converting voltage...

4. Diodes:

Function: Allows current to flow in one direction, blocks current in the opposite direction.
Variable Parameter: Threshold voltage (Uf) - measured in Volts (V).
Significance: The higher the threshold voltage, the higher the voltage required for the diode to conduct.
Construction: Two semiconductor layers joined together to form a P-N junction.
Operating Principle: Based on the principle of electron and hole diffusion. When there is a forward voltage, current flows through the diode. When there is a reverse voltage, the current is blocked.
Applications: Widely used in electronic circuits, from rectification circuits to protection circuits. For example: rectifying AC power to DC power, protecting electronic circuits from reverse voltage...

5. Transistors:

Function: Amplifies electrical signals, controls current, switches on and off electrical circuits.
Variable Parameter: Hfe (β) - current gain.
Construction: Three semiconductor layers joined together to form N-P-N or P-N-P.
Operating Principle: Based on the control of current through one semiconductor layer (base) by current in another semiconductor layer (emitter, collector).
Applications: Very diverse in electronic circuits, from audio amplifier circuits to microprocessor circuits...

Integrated Circuits (ICs): Operating Principle

Integrated circuits (ICs), also known as microchips, are assemblies of electronic components interconnected on a small semiconductor substrate. These components can include transistors, resistors, capacitors, diodes, and many other types. ICs are used to perform a wide range of electronic functions, from simple to complex.
The basic operating principle of ICs is to utilize the properties of semiconductor materials to create transistors and other electronic components. These transistors are then interconnected according to pre-designed circuit diagrams to perform the desired functions.
There are two main types of ICs:
Digital ICs: This type of IC uses electronic signals at two voltage levels (usually 0V and 5V) to represent data. Digital ICs are used in electronic devices such as computers, mobile phones, and many other devices.
Analog ICs: This type of IC uses electronic signals that can change continuously to represent data. Analog ICs are used in electronic devices such as audio amplifiers, filters, and other devices.

Essential Circuit Blocks in Integrated Circuits (ICs)

Integrated circuits (ICs), also known as microchips, are the cornerstone of modern electronics. These tiny marvels of engineering pack millions of transistors, resistors, capacitors, and other components onto a single semiconductor substrate, enabling them to perform a vast array of functions. Understanding the fundamental circuit blocks that make up ICs is crucial for comprehending their operation and appreciating their versatility.
1. Amplifier Circuits:
o Function: Amplify electronic signals (voltage or current) to enhance their strength.
o Structure: Comprises transistors, resistors, capacitors, and other components connected in amplifier configurations like BJT amplifiers, FET amplifiers, etc.
o Operating Principle: Utilizes the principle of controlling current through a transistor to modify the voltage or current at the output.
o Applications: Widely used in electronic devices like radios, televisions, computers, etc.
2. Logic Circuits:
o Function: Perform logical operations (AND, OR, NOT, etc.) on electronic signals.
o Structure: Consists of logic gates constructed from transistors, resistors, capacitors, and other components.
o Operating Principle: Employs the principle of switching voltage states (0 or 1) to represent the outcome of a logical operation.
o Applications: Employed to build central processing units (CPUs), control circuitry in electronic devices, etc.
3. Oscillator Circuits:
o Function: Generate electronic signals with a periodic oscillating waveform of specific frequency and amplitude.
o Structure: Comprises transistors, capacitors, resistors, and other components connected in oscillator configurations like LC oscillators, RC oscillators, etc.
o Operating Principle: Relies on the principle of charging and discharging a capacitor coupled with transistor amplification to produce an oscillating signal.
o Applications: Utilized in electronic devices like clocks, radio transmitters, etc.
4. Memory Circuits:
o Function: Store data in the form of electronic signals.
o Structure: Consists of memory cells like flip-flops, SRAM, DRAM, etc.
o Operating Principle: Employs the principle of altering the state of memory cells to retain data.
o Applications: Employed in electronic devices like computers, mobile phones, etc.

5. Pulse Generator Circuits:

· Function: Generate electrical pulses with square, triangular, or other waveform shapes at specific frequencies and amplitudes.
· Structure: Comprises multivibrators, 555 timer ICs, and other components.
· Operating Principle: Utilizes the principle of charging and discharging a capacitor coupled with transistor amplification to produce electrical pulses.
· Applications: Employed in electronic devices like clocks, computers, etc.

6. Filter Circuits:

· Function: Eliminate unwanted components from electronic signals, such as noise, harmonic signals, etc.
· Structure: Consists of inductors, capacitors, resistors, and other components connected in filter configurations like RC filters, LC filters, etc.
· Operating Principle: Relies on the principle of blocking or attenuating components with frequencies different from the desired frequency.
· Applications: Widely used in electronic devices like radios, televisions, computers, etc.

7. Comparator Circuits:

· Function: Compare two electronic signals and generate an output signal indicating which signal is greater, smaller, or equal.
· Structure: Comprises voltage comparators or current comparators constructed from transistors, resistors, capacitors, and other components.
· Operating Principle: Employs the principle of comparing the voltage or current of two input signals to produce an appropriate output signal.
· Applications: Utilized in electronic devices like control circuits, timing circuits, etc.

8. Signal Conversion Circuits:

· Function: Convert electronic signals from one form to another, such as converting analog signals to digital signals and vice versa.
· Structure: Consists of A/D converters, D/A converters, comparators, filters, and other components.
· Operating Principle: Relies on the principle of sampling analog signals, encoding them into digital signals, or decoding digital signals into analog signals.
· Applications: Widely used in electronic devices like computers, mobile phones, etc.

9. Control Circuits:

· Function: Control the operation of other circuits within an IC or an electronic system.
· Structure: Comprises logic gates, flip-flops, counters, decoders, and other components.
· Operating Principle: Employs the principle of processing logic signals to control the state of other circuits.
· Applications: Utilized in most electronic devices.

10. Communication Circuits:

· Function: Enable ICs to communicate with other devices in an electronic system or with users.
· Structure: Consists of communication buses, buffers, communication controllers, and other components.
· Operating Principle: Relies on the principle of transmitting and receiving data between devices.
· Applications: Employed in most electronic devices.

11. Voltage Regulator Circuits:

· Function: Provide a stable voltage supply to other circuits within an IC or an electronic system.
· Structure: Comprises transistors, Zener diodes, resistors, and other components connected in voltage regulator configurations like linear regulators, switching regulators, etc.
· Operating Principle: Utilizes the principle of adjusting the output voltage by modifying the resistance or current through the transistor or Zener diode.
· Applications: Widely used in electronic devices like computers, mobile phones, etc.
These essential circuit blocks form the foundation of ICs, empowering them to perform a vast array of functions that underpin modern electronics. From amplifying signals to processing data and enabling communication, ICs have revolutionized technology and continue to drive innovation across various industries.
Many sources
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2024.05.15 16:43 radondude My Bladder Cancer Experience

I get a lot of messages asking about my cancer, so before I get to my story: I highly recommend visiting BCAN.org and asking to be paired up in their survivor to survivor program. Every diagnosis is different and the survivor to survivor program pairs you with someone with similar age, gender, and diagnosis, so you can ask all about their experience. I have enjoyed volunteering with the program and the newly diagnosed that I speak to seem to as well.
My story:
In March of 2020, I was diagnosed with Stage III muscle-invasive bladder cancer. Leading up to that diagnosis I had recurring episodes of extremely painful urination for nearly two years. Not a drop of blood in my urine. The episodes were becoming longer and more frequent. I had urgency and an extreme pain that had me calling out sick from work. It was pure misery and by the time I was diagnosed it was actually a relief.
The test I urge anyone reading this to get is a urine cytology. I am not a doctor and this is not medical advice. In my experience the urine cytology saved my life. It's a cheap "pee cup" test you can get at any urologist's office. More info here. My easy to remember rhyme is: if it burns when you pee, get a urine cytology.
Up until that test, doctors had been meandering down a path that was not focused on cancer. I was 33 years old (37M now) and due to my young age they didn't consider cancer. I had been in some mountain bike accidents with pelvic trauma so I was misdiagnosed with Pudendal Neuralgia. Symptoms matched but the treatment offered no relief.
I did my urine cytology. 15 minutes later "Atypical cells" led to a bladder scope and I was looking at my tumors in the urologist's office. The tumors were biopsied and I was scheduled for TURBT. This is where my stage III diagnosis was given. I felt immediate relief from the painful urination after tumor removal. The tumors were pressing on my ureters so it felt like kidney stones all the time. We immediately started chemo and my doctors began telling me I would lose my bladder. I did MVAC chemo for four rounds over the summer. This was very intense: what you think about when people say chemo. Lost my hair--gained weight which is not uncommon--and overall felt like shit. After that I was given a few weeks to recover and then had a radical cystectomy with neobladder diversion in August of 2020. This was not an easy decision but the prognosis was best. I tend to trust the data.
SHOUTOUT to my medical team: Dr. Bupathi & Dr. Monticelli of Rocky Mountain Cancer Centers; as well as Dr. Shandra Wilson my urologist and surgeon. Their skills and expertise assuaged all my concerns and made me feel so confident. THANK YOU SO MUCH. For those reading: get a good team; ask lots of questions; and don't be afraid to get multiple opinions. I keep several journals, which help a lot and I'll detail that at the bottom of this post*
Recovery from the neobladder surgery was the hardest part. I had a foley catheter and "grenade" for six weeks or so. My cath bag looked like a bag of red wine due to blood. They walk you around a lot to recover faster. It involved a lot of bed-rest intermixed with short walks. I think I was out of the office for at least a month. I am in generally very good physical shape and even several weeks after this procedure it was hard to walk more than 1/4 mile.
From there I thought I was cancer free. I lead my life with my family**. Here is what saved my life again: Signaterra testing. Dr. Bupathi had these tests scheduled every six weeks. It tracks genetic cancer markers in your blood. The test results look like the stock market except you want it to go down. After several months we noticed it was rising again. We ordered a PET scan, found enlarged lymph nodes, and determined my cancer had returned (or never left). I began a second chemo regiment followed by immunotheraphy (that I just completed yesterday!!!). CisGem chemo was quite difficult. The C in MVAC stands for cisplatin and it's generally one of the hardest drugs to tolerate. After a few difficult rounds we switched to carboplatin and it became much more tolerable. After that I did two years of Bavencio/Avelumab. My Natera test results showed that my cancer had dropped to untraceable levels during chemo, so I effectively beat it before starting the PDL1 inhibitor therapy. However, my team strongly encouraged me to complete the immuno. To me, it felt like putting out a campfire: add water, stir, add water, stir. You gotta make sure it's really gone!
The bavencio PDL1 therapy caused me a lot of mood swings and sometimes caused immune system flare ups (i.e. "immuno flu"). For the physical flare ups I used prednisone, as needed. I tried to do so sparingly as it basically cancels out your treatment. The mood swings were the worst. I would often be despondent and depressed for a few days after treatment. Other times, I'd feel no mood alterations. Most often, I'd be extremely irritable for about a week after treatment (treatments were every two weeks so it was very difficult).
I'm now two years cancer free and beginning my recovery from the immunotherapy treatments. I am so happy to live in an age of modern medicine. Within my lifetime many cancers will become manageable diseases--it appears to me that bladder cancer already has. Reach out to BCAN support groups and DM me if my post didn't answer a question of yours. Good luck! You got this!
*Journaling helped me tremendously. I had three journals (google docs). The first was an overall journal detailing my doctor visits. The second was a symptom journal. The third was an insurance journal/spreadsheet. The first journal served almost as a blog, which I shared with close friends and family. That way I didn't have to have the same conversation over and over. It's nice to have family and friends interested, but it does wear at you when you have to tell the same doctor visit over and over to people. This cut down on those discussions and allowed me to have more enjoyable calls with well-wishers. The second journal I would write down daily side effects and 1-10 pain scales. This was extremely important because I could bring it up with doctors and I wouldn't have to remember how I felt, I could look it up. It also helped me understand insidious side effects that take months to reveal themselves. This was the most important journal and kept me sane. There are soooo many side effects and when you start a cancer treatment program you often have no choice-- so why read them? Well this journal would help me understand when something was a side effect. Often just knowing that it wasn't you it was the drug would have a calming effect. The third journal was so I could fight insurance and get what I deserve. Insurance companies try to reduce payouts through exhaustion. They want you to give up. By documenting your experience you give yourself ammunition when you have to escalate a claim or file an appeal. You have everything laid out in an organized manner. You can get it out of your head and onto a spreadsheet so that you don't think about it when you go to bed at night. I had to file appeals several times, sometimes with Colorado Division of Insurance and my record-keeping was a tremendous boon to my case. Don't pay a bill as soon as you get it! Wait until you get the claim record from your insurance company and make sure the number on the bill matches what the insurance company told you to pay. If you cut that check wrong, you'll seldom get that money back!
**Neobladders do not have musculature like your normal bladder. I had several very severe bladder infections--a few that led to hospitalization. During the first 18 months or so, I was not catheterizing becuase I was under the impression that my new bladder worked. I peed constantly; however, I was retaining over one liter of urine at all times. This urine kept becoming infected and putting me in miserable situations. Under my urologists advice, I began cathing and immediately felt great. I lost nearly 10 lbs in "water weight" and no longer have any urgency issues. I can sleep through the night, but often will cath around five hours into the night just so I can sleep in later. On average I cath about once every three hours. It's not painful when done correctly. It's honestly just tedious. However, after all of this the only way my life is abnormal now is my cathing. I can swim, climb, play with my son and do any physical activity; it just takes longer to pee now. I'll take that win!
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2024.05.15 16:05 healthmedicinet Health Daily News May 14 2024

DAY: MAY 14, 2024

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2024.05.15 15:09 Joleleyin Hereditary diseases in human

Hereditary diseases in human
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Many human diseases are caused by microorganisms — bacteria, viruses and fungi, which, penetrating into our body, break its normal functioning. However, some diseases affect their victim already at the moment of the merger of the sperm with the egg, when a new life only emerges.
These are hereditary diseases. They got their name because they are transmitted to children from their parents along with chromosomes — blocks of genetic information stored in cells. These include blood diseases such as hemophilia, Down syndrome, cystic fibrosis and color blindness. Unfortunately, the list of hereditary diseases is very big.
Inherited diseases are congenital defects, but they should not be confused with non-hereditary illnesses such as heart disease or deformation of the limbs that are caused by disorders during the period of prenatal development.
All hereditary features of a person — the color of hair and eyes, the blood type, the shape of the nose and teeth, the drawing of papillary lines on the fingers and to some extent the growth, intelligence and temperament — are determined by a set of chromosomes in the fertilized egg, which consists of 46 chromosomes grouped in 23 pairs. Each pair is unique in shape and size and visible only under a powerful microscope.
Sex cells — male sperm and female ovum — have only 23 chromosomes, that is, half the set. At the moment of fertilization, the chromosomes of the future dad merge in pairs with the ones that belong to the mom.
In the process of the formation of germ cells, the genetic information of the chromosomes of each pair is mixed. As a result, from each sperm and egg, unique chromosome sets are formed, the variety of which is infinite. That is why every person in his or her own way is unique, and, say, the older sister inherits from the father the shape of the nose and the color of hair, and the younger looks more like the mother.
Only in exactly identical twins genetic information is identical. However, even in this case, there are minimal differences between them, for example, different fingerprints.
Each chromosome contains many thousands of genes, or miniature blocks of genetic information that determine one or another characteristic. For example, the gene that defines the color of the eyes carries one of two pieces of information — either blue eyes or brown. When two different genes meet, one of them usually becomes the main one. The gene that “won” is called dominant, and the one that “lost” is recessive. The gene responsible for the brown eyes dominates the one that is responsible for the blue. A child, who inherits a brown-and-blue pair of genes, will have brown eyes. The pair "brown-brown" gives brown eyes, and the pair "blue-blue" — blue.
If the color of the eyes is determined by one pair of genes, then characteristics such as growth are controlled by many genes, although other factors, including nutrition or exercise, also strongly affect our growth. Most common hereditary diseases are associated with only one pair of genes.
The emergence of hereditary diseases is due to two main causes. The first and most common — absent or abnormal gene. The other cause of hereditary diseases is the presence of the wrong amount of the chromosomes in the gene.
Since the carriers of the genes — the chromosomes — are coupled in pairs, the absence of one or another gene means that another gene from the incomplete pair starts acting. This fact may or may not be the cause of the diseases, depending on what task this gene performs. So, the lack of a gene responsible for the color of the hair will not cause serious consequences. Inheriting an abnormal gene from one parent is dangerous only if it dominates the healthy.
The cause for one of the most famous hereditary diseases — Down syndrome — is the wrong amount of chromosomes in the cells. Patients with this disease are characterized by their appearance: a round face, wide nose bridge and slant upwards eyes, short fingers and muscle weakness. They often suffer from mental impairment and have difficulty in learning. In each cell of the body of these patients 47 chromosomes instead of 46.
In addition to chromosomal anomalies, the cells can also affect mutations of genes. They often lead to the formation of enzymes that produce genes, and as a consequence, to the abnormalities in the functioning of cells. The end result of such a mutation depends on the normal role of this enzyme — for example, pigmentation or growth. But since almost all genes form pairs, a normal twin gene can mask the development of an abnormal gene for defective enzymes. Such genes are called recessive. To produce a noticeable effect, they must be present in double amount.
There is another, much more rare hereditary diseases cause — the presence of an abnormal gene. Not being part of a chromosomal set of parents, it is still present in their sperm or egg cells. Achondroplasia — a kind of dwarfism — is due to the presence of a dominant gene in one of the chromosomes, which controls the growth of bones.
Sex-linked hereditary diseases
One of 23 pairs of chromosomes contains genes that are responsible for sexual characteristics. Women have two X chromosomes, and men have X and Y chromosomes, of which Y is slightly smaller than X.
Some hereditary disorders are due to the presence of a wrong amount of sex chromosomes — in some cells, the combination of XXY or XYY may be present. Carriers of the XXY combination often suffer from underdevelopment of reproductive organs and infertility. The combination of XYY leads to less severe anomalies. The carriers can have children and vary in height, but they still lag behind in mental development.
The cause of hemophilia and color blindness is a defective recessive gene bound to X chromosome. Therefore, these hereditary diseases are commonly found in men. Y chromosome does not have a normal dominant gene capable of suppressing the effect of a defective gene, and women suffer from these diseases only if they inherit the defective X chromosome from both parents.
Diseases, such as hemophilia, are transmitted from generation to generation, and physicians have learned to determine which parents can give birth to children with hereditary illness. Genetic abnormalities affect about 1% of all newborns. But if a couple already has a child with a genetic defect, the risk of predisposition to hereditary diseases in the second child is much higher than in other kids.
Scientists are constantly looking for ways to replace or correct abnormal chromosomes, and in the future hopefully we will learn to prevent many hereditary diseases by changing the genetic information contained in the sperm and female egg.
submitted by Joleleyin to RXPRBLOG [link] [comments]


2024.05.15 14:31 Canned_Bucket Proof of infinite cell theory

Now if you would take a look at this diagram, surely you will gain the ability to measure how likely it is for a creature to contain an infinite amount of cells in its body
DDDDDDXDDDDDDXDDDDDDDDDXDDDDDDD
FORTY TIMES PI EQUAL NON LINEAR NUMBER
 DDDDDDXDDDDDDXDDDDDDDDDXDDDDDDD 
NON LINEAR NUMBER DIVIDED BY THE NUMBER OF CHROMOSOMES IN A CREATURE WILL ALWAYS BE SMALLER THAN ITS PROVEN CELL
DDDDDDXDDDDDDXDDDDDDDDDXDDDDDDD
Why, why is it like this......
 OUR DIMENSION CANT EVEN COMPREHEND THE !POSSIBILITIES! 
DO .
YOU . REALIZE .
HOW MUCH THIS MATTERS.
submitted by Canned_Bucket to LibraryofBabel [link] [comments]


2024.05.15 14:18 HeadBoy9 Prison days #355, #356, #357 (Sunday, Monday, Tuesday, 12, 13, 14, 2024)

Many turbulent waters have passed under a very narrow bridge these past three days. We feared fear itself on a different level and experienced some of the biggest stress we have in a very long time. We were locked almost 24 hours (20 minutes of open-out time on Monday and Tuesday).
Considering that most of us don't eat the prison rations, we hungered and thirst greatly. At some points food and water became scarce in the entire yard. Bread was completely unavailable and treated and packaged water was spent. All sellers sold out within the first 20 minutes of opening on Monday. Since there was nothing entering or leaving, by Tuesday afternoon, no food or water could be found at any cell or anywhere within the yard.
Remember, the first news of an imminent search came on Saturday night (Day #354) and we did an emergency hiding of our phones. We were all scared and restless, the hiding wasn't safe, we only hid anywhere that looked like something could be put in it. It was already late when this info came and we were all already locked in and couldn't, well, go out, so we only did our hidings within and around. During the day, the following morning, we used our phones until locking time before the hiding began again and stretched into the night. (I'm talking about Sunday evening/night now).
I sent mine along with the accessories to the workshop for safekeeping while others hid theirs in many creative ways. Officially, cells collected their phones together in a plastic bucket and holes were dug within the blocks and they were buried. This was done under the cover of night.
COs opened our cells and instructed us to do it and make sure no contraband remained in any cell as this would always bounce back on them. They didn't want that and so had to aid us. The external search party that came was directly from the nation's capital (HQ of corrections) and were therefore superior to any officer in this facility. Even superior to the state comptroller of corrections. It was a pretty tense situation for us inmates and as well for them COs.
On Sunday night, I slept quite well after we'd hidden our phones and stuff, mine in the toilet at the workshop and others majorly buried in the ground inside blocks. Early in the morning on Monday, when the search was to begin, was when we had the most anxiety. The cells and blocks were just too troublingly quiet. I mean it was so quiet it was deafening, literally. Like a pressure built up in my two ears and everything paused and people moved in slow motion, kind of quiet.
Suspense. Suspense. Suspense. In the morning, before they eventually showed up, we were dying of suspense. Being fortunate as a result of the positioning of our cell, we have a window that can see a greater part of the yard, as well as the main gate far up front. For this morning, everyone wanted to stand at that window and mount the sentry. Thump, thump, thump our hearts thumped and silence remained deafening.
Finally they started trickling in with swag after some waiting. Big, mean looking dogs pulled by big muscled, mean looking COs, were in front, and came charging in. These hellhounds looked as though they had a score to settle with the inhabitants of this hell and would tear them and their abode apart if they got the chance. They didn't!
I'm talking Monday morning now.
Some dramas unfolded that wouldn't permit the hounds to have their fun. What happened was that immediately the search company entered, they turned left and began marching to Back Cell. This is the place where the hardest death row inmates are kept. So, as soon as these condemned guys knew they were coming, they let out such demonic shouts that rent and vibrated the previously unsettlingly quiet atmosphere, cursings and threatenings of stabbings and stranglings, and forced feeding the intruders their overnight shit defecated into plastic containers, echoed.
Such terrible roars their shouts were. The other two blocks, besides Back Cell, where death row inmates are kept, on hearing their fellows, also joined in on the bawl. As Back Cell shouted one thing, it was picked up by the other two blocks, rebounded and volleyed back into the uttermost parts of the prison. They sort of formed a shout transmission triangle.
This development was psychological, calculated and halted our unwanted visitors dead in their tracks. Men who were as good as dead had told them they weren't wanted and would have their deaths fast-forwarded if they advanced further. Their march now paused, they had no choice but to think deeply about all the possible options. To be sure, the losers would be them if they chose to engage foolishly. Dead men have nothing to lose, you know?
After much consideration, the company put forward the Chief of the yard and the resident Deputy Comptroller of Corrections (DCC) to go reason with their dead men. They did and the men told them the only thing they could promise them was deaths if anyone dared to step beyond their designated buffer zone.
Back Cell won. The company then had to send their war dogs out of the yard and adopted a more friendly mien all in a bid to diffuse tension and tone down aggressions. I would say it worked because the shouts died down and the next death row block they turned to cooperated and the search began.
They were very thorough and took a lot of stuff but surprisingly very few phones (already buried, yo!). Knives, belts, bottles, electric stoves and kettles were all taken. Gold blings of all types and serious cash were found and confiscated from the rich blocks. Contrary to expectation, the workshop where my stuff was hidden was searched. I died immediately they marched in there and remained dead, though walking around, until the next day. Not knowing if they took my things was harder and more torture than if they'd actually taken it and I knew immediately. I suffered for hours.
My block wasn't visited until Tuesday. By this time, the searchers were already spent and the aggression had left them and returned to their HQ (lol). The tendency to be dicks and bullies had fizzled out, now they were too nice. I needed to check if I hadn't woken at the Four Seasons somehow for how civil they were.
Tell you what? Technically, they didn't search our cell. As soon as the searchers arrived at our block, our cell being the first, they gathered in front. One got very close to our gate and codedly asked that we arrange money and give him so he wouldn't search us and we did. Turns out only five of the company were the ones allowed into the cells to do the actual searching and he was the leader of the five.
Having slipped money into his hand while we were moving out, they merely made a show of searching the bunks closest to the gate where their colleagues and Superiors stood, but took nothing out even if it was an exhibit. They didn't touch the bunks deeper inside at all. We were made to sit on the ground in front of our cell while they did their thing inside. After a while, they came out with only two laughable things and declared to their boss that our cell is clean (lolz, the money we gave them was equally clean).
Actually, why it was like that was that Authority didn't want us to be searched at all but had to do it to fulfill all righteousness. The DCC told them if they don't search everyone, fighting would break out. The people searched and their things seized would cause trouble. So they only came to our block not to search but for show. Our block has the most impeccable record of any block and our cell stands out of any cell in the block for good behavior.
I later understood that the search was originally targeted at the death row guys at Back Cell, Blocks One and Two, and B block. Other places searched were only as a matter of necessity to serve as cover and to even things out and not hurt already hurt feelings. Principally, it was that transgender in Block Two that singlehandedly attracted and brought this search upon us. He was using his phone recklessly on social media, doing live videos and shits. The extent of his popularity gave his actions a lot of visibility and a lot of powerful people saw it, hence the searchlight fell on prisons.
When it was all over (Tuesday evening), they opened us for only 20 minutes to stretch our limbs but that was just all we needed. Everything buried in the ground was uprooted and I got my phone from the workshop as well. Belts and other things followed later. Hunger and thirst was tough on us these few days. Honestly, prison would be unbearable without our phones, many of us found out during this period. I rest my pen for now.
Tomorrow is Wednesday and normalcy will return. I'm almost thinking: why go through all that trouble for nothing? I may as well have had my stuff tucked away under my bunk and be safe. Anyway, better safe than sorry.
Goodnight Diary!
submitted by HeadBoy9 to PrisonDiary [link] [comments]


2024.05.15 10:56 Clueto are there any videos that show the internal anatomy while someone is singing?

I am very scientific and visual when it comes to learning. I am also super detail-oriented. I like to know everything that is happing so that i can best replicate it. I am gonna put a link of a video kind of what I'm talking about https://youtu.be/wYwk07QM4rc?si=oataxo2WQglDj3Hi . Except I am wondering if, instead of speech, there are any videos where a diagram is shown while sounds of singing are being made. I am having a lot og trouble with my onsets and I want to see exactly how the throat, mouth and body move from a relaxed position to a singing position . I want to see what moves, how much, what sounds make which muscles move. I know this is a lot to ask, but if you know of any videos/ apps pls lmk. Thank youuuuuu
submitted by Clueto to singing [link] [comments]


2024.05.15 08:41 Ravens_Quote The Hangknell Leper- Chpt. 1 (might write more, idk, depends on feedback)

To live in the Undead Burg is a daily test of one’s wit and their will. The brutish and dull fall to the cunning, and the weak intellectual tears their own mind asunder. For those who escape the Asylum, it is sometimes enough to make one consider voyaging back to their cell.
After all, only a few are Chosen.
In the lower levels of the Undead Burg, a cloak of rat skin fluttered behind a walking corpse as they hurriedly turned the corner of a short length of stone stairs, slamming the shield of a hollow soldier against the ground just as the claws and fangs of the first hound rose to meet it. In truth he lacked the strength to properly defend himself with the thing, to raise it with only one arm and withstand a blow with the same, but it didn’t matter here. The lower corner of the shield lay braced against the bottommost of a length of stone steps. This, with his shoulder pressed against the shield’s top, made progress against him nearly impossible for a foe so light as this.
If idiocy was to lose one’s common sense, then it couldn’t account for the stupidity of an undead hound. The corpse raised a spear over the shield and swung it downward in a pathetic arc, the wood slapping against the metal with hardly a noise to report. Seeing the motion, the dog leapt sideways out of some horribly trained reflex, and in this manner crashed into large pile of eternally burning corpses. It yelped as the heat caught it, spasmed as it searched for purchase amidst the mass of charred bones and melted flesh, and promptly died. The commotion brought with it the sound of distant footsteps, and soon another beast had run headlong into the shield. This one took two similar “attacks” of the spear to repeat its fellow’s mistake, and the one after it four.
To think he had once been terrified of these things, and discovered his tactic in panic.
Beside the steps was a well, and (after a moment to ensure no further dogs were coming), it was this against which the corpse laid his heavy shield. The next test between him and his goal would require agility, something ill-afforded with such heavy hardware. For this, he turned his attention to the well’s crank, and set thereafter to turning it. From the depths was raised a target shield tied in place of a bucket, and upon it a collection of bones, a severed hand, a ring, and a candlestick. The corpse laid the miscellaneous treasures aside, untying the shield and equipping it to his left arm.
The first two thieves were marked by buckets… or rather, the buckets were set in place to tell the thieves which doors were to be hid behind. As travelers came and went, the buckets would roll down the hill as they were knocked aside or blown by the wind or carried around by the dogs, and thus the thieves’ stations would move. When it was determined one had rolled too far down the decline of the alleyway, an annoyed thief would inevitably carry it to a more desired station, pretend it had always been there, and hide themselves behind the newly marked door. It was possible some band of thieves set this tradition in place long ago and retained the habit after they’d eventually gone hollow, but proving this thought today would be nearly beyond impossible. The reasoning didn’t matter to the corpse, of course, but the effect he used to his advantage.
The tops of the doors he adorned with knives from the Lady of Moss- blades up, such that the forceful opening of the door would spin the knives just right to sink their poisonous bile into the victims below. What additional wastes and acids the corpse had applied need not be mentioned by name, only that they shared their patron creature with the leather cloak on his back. With his work done, he now walked the side of the alley as any clueless traveler would have, and awaited the springing of the trap.
As always, the third and lowermost thief signaled the attack by kicking open their door. The two now behind the corpse followed, and shortly thereafter issued their raspy exhales of pain amidst the clatter of falling steel. The corpse charged. The leader hurriedly reached for their throwing knives but was swiftly force-fed the edge of the corpse’s shield, thusly to be brought to the ground. Here was the corpse’s blade drawn, its cracked and jagged tip turned down towards its latest prey.
When skinning rats, it is important that one carries a sharp blade. This both to pierce the thick hide, and to avoid unnecessary damage to the intestines, stomach, and other usable bits lying beneath. Replacing the rat with a hollow, the corpse preferred the tip of a broken straight sword to the edge of his usual dagger. The motions made indeed bore some crude similarity to his work when harvesting leather, but the abandon of care became only more evident with each forceful cut and flailingly resisted gouge. In the end, what remained could hardly be discerned from a spot of muck on the road, a hollow-faced madman above it.
Further down, beyond a second set of stone steps, was another favorite spot of ambush for the thieves. The mutts at the end of the alley had long since devoured whatever scraps had been used to position them, and so readily charged forth at the beckoning call of the corpse. They found at his feet the now separated legs of the corpse’s most recent kill, adorned in many fresh gouges and oozing with a pungent liquid. The source of this meal mattered not to them, and so they eagerly set to work engorging themselves on the new flesh. So single-minded were they, intent on ridding themselves of the insatiable undead hunger that plagued them, that neither one slowed as a white foam began to pour from their mouths. Their stomachs first bulged, then split apart and spilt what little they had for content as the acid worked its way through. Their legs gave way from beneath them, first the hind, then the front, and yet still they desperately swallowed more of the decaying flesh and embedded stomach-skin pouches that rapidly digested them in return. When at last the pair had at last lost such strength as to no longer reach the meals inches away from their first gasping, then whining maws, the corpse delivered their mercy. A swift kick, and what little remained of their necks gave freedom to their lifeless skulls. The thieves, meanwhile, bore no challenge the corpse had not already faced. Knives over the first few doors, the greeting of jaw and shield, the pillaging of another victim. Nothing unusual, and nothing of note.
With the capra demon gone, some “chosen” adventurer having long since vanquished it from realm, little now stood between the corpse and… her… save only one thing. The corpse took the last flight of stairs three at a time, ricocheting off the wall on the outside of its only turn and bounding towards his target.
There she was, out in the open as always. The corpse sprinted down the stairs and, after passing a blind corner, set his left foot forward and crouched to halt his considerable momentum. The ambusher behind him was easily parried as he brought his shield up and behind him, cracking something in their forearm or perhaps their wrist. Not bothering to waste time, the corpse’s broken blade was brought upwards through the ambusher’s jaw until it snapped the bit bone between their eyes. This done, the corpse wrenched his weapon up and sideways with a hollow “pop” as the neck gave leave of its skull. The body collapsed to the side, its head twisting unnaturally upwards and backwards as it freed itself of the blade. The corpse, unbothered, bore no interest in holding either aloft. Now he turned, inspected the last of the thieves, and after a moment returned his blade to its holder.
“You are Patient.”
This first time he’d uttered the phrase, the last word was merely an attribute. ‘Twas a description of the one hollow that could be shot with any arrow, afflicted with any pain, and would yet remain loyally in her position. To be fair, it wasn’t for great gift a choice, as the position of “live bait” was reserved only for whichever of the thieves had been deemed least desirable by the rest. What caused this, and whatever penalties lay for abandoning of the post, were matters the corpse could only assume. The important part was that it was her, the thief who had become “Patient” by name. At their first encounter the corpse had considered dispatching her like the rest, but had hesitated in piercing her skin. He still bore the scar about his neck that she had given him for his idleness, and she still wore the rat skin “grieves” he’d forcefully tied to her for a marker. As time passed, the two gradually traded more scars and more black fur hide between them- the corpse receiving the former, Patient gaining the latter. He had stripped her and tied a pelt about her chest which lay now beneath her leather armor, he’d fashioned a double-thick leather stock to protect her neck, and though he tied gloves to her at a point she’d taken great effort in cutting them off. All this he had done across many visits, through much pain, and at expense of his best materials. Todays gift had by far been the hardest to craft- a thrice layered leather helm affixed on one side with a jawbone to replace what he’d broken so long ago.
His approach was slow, and well-rehearsed. At about ten paces, Patient’s patience finally broke as she ran for him. Today she chose to hesitate upon reaching him, though he'd learned this was by chance of random choice than any form of compassion. The corpse waited for the attack, not daring to kick another outcast as he had once been in life. She tried first her more viscous pattern, a pair of vigorous strikes that slid across the corpse’s target shield rather than bouncing away. She completed the maneuver and immediately prepared for a more powerful, slamming attack, granting the corpse the opportunity he had been seeking.
As she brought her blade down, the corpse deftly batted her strong hand away and gripped her shield with his open hand. Having no further need for his own shield, he cast it now away and spun the patient thief ‘round. She made as if to leap upward and over the corpse, but the maneuver was one he’d long since learned to counter. He stepped back, spinning himself so as to bring her sideways and around and down into a prone position with his right elbow along her back and his left hand pinning her knife arm down.
His next task, before gifts could be given, was to ensure he received no further scars in return. Placing his knee at her back to free one of his hands, he drew from beneath his cloak a coil of red twine fashioned from the same rats he’d skinned for his gift… some of the same, at least. With great effort, the twine was managed around the thief until she could no longer terribly well resist, and her hood was pulled back from her head.
Seeing the sunken red skin, the glowing eyes, the bare teeth, it reminded the corpse of life in the Pit of Outcasts. It was there he’d met the kindest of the living, the most desperate of the poor, and occasionally even a soul or two willing to speak or come close to him. ‘Twas a place for the diseased, the undead, and those criminals deemed too vile to disgrace the hangman’s noose with their neck. It was there he’d learned to knit and to sew, skills gifted to him from an undead woman not terribly discernable from the one before him now. The main difference, at least for now, was the slack jaw broken in uncountable pieces during their first encounter.
Casting the memories aside, the corpse set to his work. The leather about the thief’s neck stilled her head a little, but precisely cutting the skin beneath her jaw to remove the old bone was still a difficult task. The end result was unsightly, and it involved more than a few excessive cuts from the patient’s constant struggling, but it was enough to work with. Removing the old bone took a great deal of time thanks to the many fragments hidden in odd bits and pockets of flesh, but sliding the new one into place and wrapping it in the old muscle proved as easily said as done. The most tiring part was retying the cuts back closed, as the thief regained and continually demonstrated a greater ability to bite and snap as the corpse made more and more progress. The last of these gaps closed, the corpse finally wrapped the rest of the leather helmet about the thief’s skull and tied the loose end to the other side of her new jaw with more twine. It wasn’t his best work, but it was the best he’d done on something still kicking around.
Patient’s hood was returned to its proper position, and the corpse took hold of a length of twine connected to a slipknot in the middle of her back. Midway up the last stretch of stairs he’d come down, the twine was pulled and the knot it held gave way, restoring the thief her freedom. Knowing better than to stick around, the corpse fled to the top of the stairs, standing on the bridge overlooking her station just beyond where she would pursue. He watched as she freed herself of the last of the twine, as she looked to him, and as she eventually returned to her post. He said then the same thing he always said to her, though still he knew not if she recognized it.
“I am Aldin Paltry, the Leper of Hangknell. I will return again.”
He watched a moment more, but was paid not a glance in return. Back through the alley he went, bound for the dragon’s bridge.
submitted by Ravens_Quote to darksouls [link] [comments]


2024.05.15 07:49 GearedVulpine Every day matters

Every day of your restoration journey matters. While that doesn't seem true, the progress adds up:
(1 micrometer or μm is 1/1000 of a millimeter.)
Every day you tug, your foreskin gets slightly longer. My rate of progress, 3mm/month, doesn't seem like much, but that's a millimeter every 10 days. I only notice a small change every week or so, but my cells are always doing their work in the background and dividing. Growing, probably, not just skin and mucosa cells, but nerves, nerve endings, capillaries, smooth muscle, and everything else necessary to create new tissue.
A day not tugging means you reach your goal about a day later. A week not tugging means you reach your goal about a week later. But we all want to be restored as soon as possible. That's why maximizing time under tension is so important. Make today the day you grow 60 or 100 micrometers of tissue, not zero. But even better, set an ambitious routine and stick to it!
submitted by GearedVulpine to foreskin_restoration [link] [comments]


2024.05.15 06:33 Global-Marketing414 MVIC

Maximum voluntarily isometric contraction is method that uses max effort at specific angles trough range of motion. It can be done pushing or pulling against barbell, ballistic manire ( rapid force development and good for RFD ), ramp up manire ( gradualy increasing force to peak than sustaine ). There is no visible move but muscle fibers are shortening and elongate same as tendions and with MVIC contracting (that is why MVIC have good transfer to dynamic concentric strength. Old researches, many people and some choaches say that transfer is around 15° in both ways from point where is done and that is partially true at short muscle lengths. Researches show that when done at long muscle lengths where muscle is stretched (begining of lift) have grater transfer on range of motion ( more degreese ) how much depends of way have and where it's done, elict more hypertrophy and maximal strength but causes more fatigue. On short lengths have smaller transfer trough range of motion and because of that is more angle specific elict less hypertrophy and maximal strength but cause less fatigue. Some say to do isometric at long lengths only, some say no more than three positions and some on sticking point or regions ( it's vary strong tool for this because of great strength gains). Researche done by Danny Lum and others shows that doing one angel (90°) and multiple angle (90°+2 angles) elict same gains in maximal strength but multiple angle groupe was better at ballistic exercise producing more power. With MVIC activation of muscles motor units is 5% to 10% higher than with concentric and eccenrtic contraction and have many times longer duration of max muscle activation ( used like potentiation effect before power sets ). While you go by certain angle in range of motion in miliseconds with dynamic move with MVIC aim it for few seconds ( because of that it's been used on sicking points to improve weak areas ). Many people don't belive in them because of lack informations and they do them wrong (application) but people like Alex Natera (sport specific running) use them for year like stand alone method for prepearing athletes.
I try it like stand alon method at one period of my training to see by my self how does it works.
For BP start at chest level 0cm first position next positions goes up 5cm each to lock out what is in my case 45 cm of ROM, so 10 positions from long to short muscle lengths. Next training start at 2,5 cm of chest than increase by 5 cm ( 2,5/7,5/12,5...) so in two trainings all ROM was done by 2,5 cm between angles. Effort was max 2x5/6 sec. with 2 min. of rest between reps and 5 min.between each position, that is 100 sec. of max effort all together spend in 100% to 80% range ( measure it with Tindequ Progressor for static force). I have see some hypertrophy and good strength and power gains. Some say that is too much angles that is too fatigued for CNS (didn't burn out doing one exercise daily because of longer durations). Of corse it can be used as only method and will give strength but won't last forever.
What are your thoughts and do you ever use it in your training sessions?
Have some more information how thing operate on cell level and that stuff?
submitted by Global-Marketing414 to powerbuilding [link] [comments]


2024.05.15 06:31 ShoppingCrafty9043 Random things pure biological based

The myth of losing localized fat...
When you exercise exhaustively or on an empty stomach, the evolutionary mechanisms of your brain will cause you to secrete certain hormones that will activate the burning of fat accumulated in adipose cells to obtain the energy necessary so that your brain does not collapse.
Those hormones, those chemical substances will circulate through your blood Blood circulates throughout the whole body, right, and until the level of sugar or energy is not optimal for the brain, it will continue to emit chemicals until it is.
These chemicals are coated by all cells since the circulatory system is a closed circuit that runs throughout the whole body.
This would debunk the myth... but...
Where the blood is oxygenating more, in which area, it not only circulates, but also enters the muscles deep inside,
So where are there going to be more fat burning chemicals???
...
Yes, it's true, for this difference to be noticeable you would have to be doing an intense cardiovascular exercise and muscular effort, that is, running for example, but it is very difficult for you to do abdominal exercises at the level that you would achieve an overexertion similar to running 🤷🏻‍
submitted by ShoppingCrafty9043 to mystorytelling [link] [comments]


2024.05.15 03:08 ForestHasEyes Polish GROM has been fighting a secret war for decades, our enemies aren't human [Part 3]

Blachowicz here.
Kept yah’ waiting, huh? Heh, sorry about that one, but I can explain. As we all know… we lost a few good men the last few months.
That’s the brutal part of a hybrid war like ours: We’re fighting a foe unconventional, with half our arsenal tied down because those who grant us authorization are either in disbelief of the true facts, or scared… or already assimilated. That being said our momentum recently was a change not seen in years, and because of that… despite the losses we have garnered, we were close through a breakthrough. One last night Krol pulls myself and other two must trusted squad leads into the back of our COP. There is one of our equipment cages, surrounded by m-bitter radios, tripods, and several hundred thousand dollars of equipment he brought us around a simple worn table. Before us he laid a map of eastern poland… red markings indicating cells that seemed to dot the countryside like a pestilence, or used to… as deep gashes of advance from raids had trisected their lines, even if ones did pop up in the interior.
It was a back and forth; an outside virus infecting Polska at it’s heart, and we were the antibodies sent to drive them out. To which… Major Krol points to one of the largest symbol on the map: a dark red diamond, the NATO symbol for an enemy unit, deep inside of an untouched wooded area, adjacent to a mountain ridge. Several jagged lines indicated entrenchment, with red horizontal lines indicating possible enemy control… or our contested control, for over 20kms surrounding it. Letting us all look, the Major lit himself a cigarette.
“Sir, you sure it’s wise to smoke in here with the dive tanks just behind us” 1st Squad’s lead quipped. “Fuck off” Krol dryly said.
“Alright… this is it… this is the one we’ve been searching for for years, this is the nucleus my predecessor commander died trying to find” he says, pointing to it. Not far from Zamosc, it was almost touching the border with Belarus, the contested area indicating the Strigoi did operate over it… indicating one of the largest spill through points. “-It’s an old soviet bunker, made during their 1960s initiative it was designed to hold the munitions and manpower of several units in the event of a NATO first strike” Krol explained. “It’s gotta be massive then…” I said gazing at the map; “Didn’t the army demolish all of the old soviet hulks near Belarus to prevent any infiltrations?” 3rd Squad’s lead asked. “National Police took the effort over… and by extension, the Strigoi. It was halfway demo’ed before they burrowed into it and have been using it as a bridgehead ever since. This is it…” Krol said. He looked around at all of us, a sense of certainty I had never seen before as he blew smoke from his nostrils; “We’ve been fucking around in the dark for so long, it’s hard to believe we’ve made any progress, but this is it. With this gone, this will set them back over a decade and the momentum will finally shift into our favor… into Poland’s… -Europe’s”.
I swear there was almost a flash of joy, of pride in his eyes and a phantom of a smirk before reality set back in “That being said… we can’t leave this to chance, especially not something as important as this. We’re going to have to go there ourselves… clear through every inch of that place, and tear it all down, piece by piece. I will be straight with you all… when we go, there will be some of us that aren’t coming back. -but we are going… a whole generation is counting on us, and unborn billions rely on us to succeed”. We all nodded, a silent agreement washing over us as we took this upon ourselves. Echo-1 spoke up: “So… They’re authorizing a raid? How big?”. “We’re rolling in as a hard target, armor, explosives, and air support” Krol answered, taking a drag off his cigarette. “Aviation? How the hell did we get that approved, we’ve gotten attempts shot down four times due to those leeches” I said in disbelief. “There’s too much evidence here pointing to the human trafficking tied to their actions… We’ve finally got too much weight pinning them down, to keep the hammer from slamming into their necks” Krol chuckled. He looked around “Any questions?”. “When?” Echo-3 asked. “Three hours. We’re hitting them in the dead of night, only time we could get the birds authorized. Get your boys ready. We’re rolling out” Krol said, dying the cigarette bud out on the table. I can’t begin to tell you the euphoria we felt leaving that cage, as our men started arriving, they did so a lot quicker, and with their heads a lot higher than they had in weeks. As Second Squad’s lead we were going to be one of the main arms of attack into the bunker, thus I made sure we had a breacher loaded with enough thermite, charges, and tools to cut through anything. Our shield bearer we ready to go, as was our assaulters, grenadiers, and machine gunner. I double checked each and everyone of their weapons; ensuring the feeder paws of our squad’s belt fed were intact, making sure every breach charge we had was properly set and packed. There was going to be no mistakes, no slip ups. The margin of error needed to be the smallest it had ever been for us tonight if we were going to make the gore spilt worth it.
Finally… there on the outside of the building, the bright LED lights kept the darkness of the ensuing night at bay as the roar of our MRAPs could be heard. It was said once that war is 99% peace, and 1% chaos, they were right. The slow periods where the blood slowed and the doubt creeped in was the worst… yet we all kept it at bay. We needed to, there was going to be no backing down tonight. All three squads were up, all of us ready to go… we circled up… short stares and shaky nods telling us one things: We were in this together, till the end… the finish line so many before us had been searching for, we were being granted tonight.
A single set of footsteps could be heard as we turned, Major Krol stepping into the center. He took the last drag of a cigarette, throwing it down to the ground and stamping it out onto the damp concrete. He looked around… his chin strap blowing in the weak air as he met everyone of our gazes… then mine… then looked around. “I want you to remember every detail of tonight, as you have every other night… when you are situationally aware, scanning for the enemy, liberating the subjugated, I want you to remember the sting of anxiety, the shake of adrenaline, the chill of the bunker, the heat of your weapon as it cuts them down… because tonight we are going to write every fine detail of our victory, their defeat, in history…” Krol’s words echoed deep into our souls. He paused for a moment, staring around he looked down… a small pause before he said “When you are ruthless in combat, remember to be patient, and reserved in victory. This conflict is for our existence… a lot of innocents have bled due to the mistakes of those who failed to listen, a lot of our brothers are now laid under because we had to bridge the gap of uncertainty with their lives. We remember them now… but in an hour? We forget them… when we raise our barrels, when we cut into those foes, and we liberate Polska!! This does not end tonight, but history puts everything in it’s place, and patience is the companion of the victor… All of our hard work will be cemented, no matter the obstacles we face in that darkness… no matter the demons, the blood, no matter what incomprehensible horrors, we will make them comprehend that to invade our land, to bleed our people, the justice will be paid in full… Load up. It’s time*”*.
The purpose in our steps was heavy as we climbed the back ramps of the MRAPS; Four of the heavily armored vehicles, one for each squad with an additional for attached personnel including our JTAC, the term means Joint Terminal Attack Controllers. With air support requisitioned to us for this operations, there needs to be a definite liaison on the ground who can directly communicate to the birds, and coordinate their fire and progress. I’d worked with many of them in the past, resourceful guys, quick thinking though I guess that comes with the position they hold of needing to quickly figure out what bombs to drop, on which target, at what precise points, whilst taking contact. He loaded in the lead vehicle with Major Krol… and soon, our convoy kicked off.
The drive was several hours as myself and my squad sat in the back of that forty ton goliath, the rumbling of the engine keeping us awake as the crap heater fought to keep the cold from the outside frost from setting in. I looked around to each of them, some were catching some sleep because even with the circumstances… better to get all the energy you can, than to stay awake for nothing. Others were checking their weapons… My gunner locked eyes with me, the same one from the village extraction… many of these men I had trained with for a while now, fought with for months.
We may have met on unconventional circumstances but those in JW Grom thrive on austere chance and create opportunity from scratch. I was pulled from my thought by the sound of a transmission, my peltors were set up for dual comms so I could both receive information from the Major and other leads, whilst communicating with my team.
Krol himself sent out: [“Approximately 10 minutes from enemy AO…”]. As the rest of the squads acknowledged, I quickly sent out [“Echo-2 Copies”], before kicking the boots of any of them sleeping: “Look alive, we’re here”. Through the exterior net armor of the MRAPS, and the bars protecting the small reinforced windows, we could barely see jack shit. I reached up, turning off the overhead light as we all looked through our nods to scan the outside. A dark wall of dense trees was shown before us, making it difficult to see… in addition to night vision capabilities we had also requisitioned ourselves some thermals… when mounted onto rifles they were bulky, made it a pain to aim down quickly, but considering the supernatural capabilities of spotting our foes we needed every advantage necessary.
I flipped out one of my tubes… scanning the outside with my scope. I looked over to one of my assaulters who had been assigned to man the turret of the MRAP, seated near the view screen as he controlled the 50. Cal. Each of the vehicle turrets had been assigned a direction to cover… we took the 9 o’clock, the left flank. “See anything?” I asked. He shook his head; “Negative… wait… I’ve got two cold signatures, front left heading to our rear”.
I quickly scanned the far tree line, at approximately 60 meters off our left were two cold signatures… followed by a third heading to our front… then another. They were surrounding us, moving at speeds so fast I could barely keep my reticle on them. Is this what the National Police saw? What they faced at that lodge without the benefit of a foot of heavy armor protecting them on all sides. Then… suddenly. Something slammed into the side of our MRAP so hard, it caused it to shake. From over the leader comms, Echo-3 quickly shouted [“Contact right!! 4 hostiles!!”].
One of the Strigoi… so bold, had charged and slammed into the side of our MRAP. I quickly looked to see the figure, a dark blue mass of cold energy through my thermal, back away without so much as a stagger… as they tried to flee into the woods, the white hot justice of Echo-3’s gun fired at them, cutting them down. “Blachowicz I’ve got a few breaking for our vic” my man on the turret called out, I spun around, spotting out the window.
Just then, Major Krol announced [“weapons free, watch and shoot for targets of opportunity…”]. I turned to him… “take those fuckers out-”. Without hesitation my vic’s turret began to quickly target them, and through the darkness I saw a stream of outgoing fire bisect one of them, the ISR of the black blood freaking out the optic so badly it didn’t know what temperature to register it as… but it did register it. As another was cut down, one broke through the tree line and latched onto the side of our MRAP. The thing tore at one of the outer net armor panels, usually made to stop RPGs. It grabbed at the bars near the windows, tearing one off… I lowered my rifle as we locked eyes through the reinforced window.
The thing… the Strigoi looked at me, skin cracked as putrefied muscle fibers seemed to leak through dead flesh. It’s teeth were corroded and worn down to sharp fragments, alongside newly mutated fangs that messily protrude from the jaws. Even through the thick walls of the MRAP I could hear it’s roar, as it then tried to punch it’s way through… it cracked the outer coating of the vehicle… but it wasn’t getting anywhere near. My machine gunner, seated next to me, seemed to chuckle at the sight, quippily saying “Yeah… fuck you too”. It’s then our vehicle lurched upwards, as we began to climb the small incline of the bunker. I knew the layout, mapped it in our head, the main entrance was built into the rocky side of an old cliff meaning we could easily set up a defensive perimeter around it, a horseshoe. Krol’s vehicle was first, taking to the right as Echo-3’s MRAP followed. My vehicle, third, left the incline and took a left and… that’s where things got complicated.
We’re still trying to work out what happened but… from what Joakim says his drone captured. Right when the MRAP turned, several of the monsters quickly slammed into the side of the vehicle, as another more bulkier one, pushed at it’s undercarriage. The result.. Was the 40 ton armored vehicle tipped over. It wasn’t uncommon, hell in some cases a well placed IED, a good shot with a recoilless rifle, have been known to tip over Oshkoshs and Maxpros all the time. But this beast? Needless to say we barely had a second to comprehend it as it leaned to the left; “Grab on to something-” is all I had time to shout. A mess of gear and men spilled onto one side of the vehicle as it slammed into the old gravel and dirt.
Several of my assaulters, my grenadier planted right ontop of myself and the others as we came to a stop. Someone’s knee slammed directly into the side of my skull, causing me to dazily bob in and out of consciousness as my face was smushed against the glass of one of the windows.
Through my peltors, the other squads were erratic;
[“Echo-2’s vehicle is down!!”].
[“Echo-3 to Echo-2… Echo-3 to Echo-2…”].
Krol’s voice came through the comms;
[“Echo-Lead to Echo-2… Fuc-... Echo-1 secure Echo 2’s flank, Echo-3”].
[“Echo-3 to other units, they’re spilling through, I’ve got several enemy combatants converging on Echo-2’s vehicle”].
I pushed the legs of my grenadier off my head as I fought to my hands and knees, unfucking my nods as I looked around… “Fuck it… we’re going lights on, shield your eyes” I muttered as I reached for the overhead lights and flipped them on. The bright LEDs bathed the inside of the vehicle as we all gained our bearings, a mess of multicam, gear, and weapons as we quickly pushed each other off. My gunner caught as he fought to realign his promask, from what I gathered one of the assaulters had landed directly into his gun, pushing it directly into his jugular, as pulled back at the rubber and coughed, freeing up his esophagus. We didn’t have time to think however… the sound of bending metal caught our attention… as the back ramp door of the MRAP was ripped clean off. I could barely believe it but as the white light of the MRAP’s interior poured to the outside, a hulking mass leaned in, the dead flesh on it’s face nearly fallen off as the hideous Strigoi leaned inside.
Without hesitation I aimed took aim, yelling “Keep to the deck!!” to any of those inbetween myself and the invader as I opened fire. A burst of full auto fire tore through it’s collar and neck, my men quickly clung to either sides of the fallen MRAP as a few more fired out. As the thing backed up, a blast of .50 cal fire quickly tore it to shreds, along with several others as I realized they were fuckin swarming over the outside of our vehicle. Echo-3’s vehicle continued to carefully fire on the Strigoi on the outside, the sounds of .50 cal ricocheting off the outside of our armor was enough to make the pucker factor set in.
[“Echo-3 to Echo-2”].
[“This is Echo-2, we’re green on ammo, equipment, men”].
[“Roger, we’re shifting fire, exit the vehicle”].
“Hurry up let’s go!!” I barked to my men, leading the way as I staggered out. I turned on my peq, taking aim at silhouettes in the brush as I began to fire. The sounds of machine guns lighting up the brush, as a sea of growls, howls, and incomprehensible roars fired back at us was the ambient noise of the night. My men quickly exited, my gunner being the last as he and I pulled back to the rest of the defensive perimeter. I set in my men to take up the frontal security, as 3rd squad took the right flank, 1st squad to the left. Major Krol and the JTAC were bickering with each other; “How far out are the birds”. “They’re entering airspace now…” Joakim said, already scanning his smart book.
I asked “What’ve we got?”. He then flipped through… to the NATO combined arms segment, quippily saying; “Apaches…”. This caused me to pause as Echo-3 turned their head whilst directing their squad’s fire “The hell… where did we get apaches from?”. “The Americans… they volunteered” Krol said dismissively as he took aim at the darkness, firing off a controlled trio. “Volunteered? They’re aware of what’s going on?” I asked.
Krol seemed to stop, glancing back at me before returning his focus “There’s a lot more going on than you realize, Blachowicz… Prep the breach, you and 1st are going on”.
I quickly pulled my breacher off the line, securing some thermite as the reinforced bunker door wasn’t going to go as easily as a conventional door breach would. 1st Squad pulled back, stacking up and preparing themselves to be the first in. All the while… Joakim gave his firing solution; “Alpha Hotel Two Five Nine, This is Bravo-4…… Type 2….”.
I snapped to my right, watching as a Strigoi managed to dark across the clear gravel field, only to be cut down by my gunner, the peq’s laser marking the burst as it tore through the beasts’ hips, as it hit the ground and still continued to claw, another GROM operator took aim and fired into it’s skull. Joakim popped up to his feet…. “Marking laser, high power…”. He then pulled out a target marking laser… if you’ve watched night operations, you’ve probably seen them.
The green laser than as it says on the label, marks targets. The pattern of which can vary… if it’s a point target, it’ll usually lasso an area, or remain on target until the target is removed with extreme prejudice. If its close air support, then it’ll be a line of the general area… and Joakim damn near marked the entire perimeter around us. He quickly pocketed the tool, turning back to Krol; “Don’t go past 20 meters unless you want to be liquidated”.
With that… 2nd and 1st stacked up at the door as 3rd squad took up the perimeter security. As Major Krol went over to Echo-1… I saw them. A single blinking IR strobe from the beasts as they moved on the far off horizon, converging from several angles… and fired. The sound of the Apache’s main gun, the M230, truly sounds like the hammer of god… the 30mm cannon shot through the dark sky, lighting it up as we saw three incoming streams tear up the woods. Only then as the sound broke did we start to hear their rotors as they broke and began to circle, firing again… then… Joakim dipped his head and looked to Krol; [“Foxtrot Mike, hang onto your teeth…”]. One of the Apaches fired off a AGM-114… a Hellfire. I barely saw it out of the corner of my eye as the Apache from our right flank fired off at a target approximately 200 meters off. A fireball lit up the forest as the horrendous roar echoed throughout… then went silent.
Echo-3 scanned the horizon carefully;
[“Echo-3 to Echo-Lead, enemy contact is starting to die down”].
[“Maintain perimeter, Close Air is to maintain fire mission until we are boots up, Break…”].
[“Echo-Lead to Echo-1, condition white has been met. Proceeds”]. I saw Echo-1 and his men quickly stack up close to the wall and gesture to me; Breaching. I quickly pulled my stack back against the wall as his and mine breacher quickly hit their actuators. Now under normal circumstances, it doesn’t take much for thermite to melt the locks off of a metal surface, in fact it’s a more precise took as alternative means get real medieval like saws, pry bars… we weren’t in the mood for precision, we need to breach their little lair, and drag them out. The sound of several pounds of hellfire burning through the metal could be heard around the corner as a sea of white and red sparks flew out… after several seconds, two of our men tossed a fragmentation grenade and a nine-bang through the opening… a series of concussive blasts and a large explosion rang out.
Echo-1 and his men maneuvered. 1st Squad quickly converged as we followed them in.
Stepping through the black wall of smoke, the dark abyss of the interior was illuminated in a white light as entered barrels raised. Shots rang out as several of the beasts near the entrance were cut down, though not immediately, rounds disconnected the shoulder of one of them, leading to their arm hanging limply by a single tendon as they roared… another series of rounds putting them down. What greeted us was a messy concrete hell of rust and debris, fecal matter, trash, and all kinds of obstacles laid in our way, our boots sticking to the floor. I thank every god we had promasks that night. I called my shield bearer up, 2nd squad leapfrogging ahead to take the next corridor as 1st squad checked their weapons.
One of my men mule kicked the metal door ahead, twice, finally the latch gave away as we tossed in a grenade. A horrifying roar was cut off as an M67 shook the walls of the ancient soviet mausoleum, frag and spall kicked off the walls as I moved in right behind my shield man. The cramped russian design meant there was barely enough space for three people, and that’s three normal people, not in 50kgs of kit, moving slowly and maneuvering against creatures of the dark. Still… we moved forward, my shield bearer and I pushing the pace as two stacked of either squad formed on either wall.
As we passed doorways they flowed in… “Door Left!!”, “Door Right!!”. “Move!!”.
Two men entered each side, no gunshots, we moved up, a roar came.
“Door left!!-”. A series of gunshots came out as we continued to push forward.
“Two down!!”. “Confirm them” Krol commanded, as a series of gunshots run out in response. From one of the doorways, a Strigoi emerged… a female… clumps of hair had been ripped from her decaying skull, as her blooded eyes locked on myself and my shieldman. The skin on her hands had been tore down to the point where barely her bones and tendons remain… looking like huge talons as she roared and lunged at us. He fired off his pistol, though the rounds did little to stop her as she pushed against our stack.
“Fuck!!” he muttered, somehow her strength caused him to stagnate, holding up the advance… fuck that. I shoved the muzzle of my MK18 into her ribcage, flipping the weapon to auto as I fired of round after round. The 5.56 salvo disconnecting her spinal column, causing her to fall as I continued to fire, along with a man to our right and left as the stacks reformed as we pushed to the end of the hall. I fell back, dropping the magazine and loading a fresh one, like clockwork a GROM Operator from 1st squad took my place. Krol was beside me as we approached the end of the hall.
[“-Prep an entry”] I radioed to my breacher, a comrade handed him one of the charges from his back panel as he took to the door, quickly securing it. We all moved as far back as we could, look away, exhale. The blast knocked metal and wood in all directions, scrapping against our uniforms and kit as we made our way in and what laid before us was… it used to be the center atrium of one of these bunkers. Soviet’s loved their grandiose designs, the complex was supposed to be a circular room around a central planning table… instead. It had been turned into some sort of church. Runes and old eastern Romuva pagan symbols written in black ink and blood across the walls, old rotten filing cabinets, long receipt terminals. In the center… several of the Strigoi were kneeling before the table where someone had been tied down, flayed, and… shared amongst the group. They rose to their feet, we aimed our barrels…
The ladder amongst turned to us… his skin wasn’t cracked, or flayed, it was smooth… it still looked dead as the body on the table but it seemed more… accustomed to it. I don’t know… evolved? Under the surface however I could see it’s darkened veins pumping whatever cursed blood ran through them as it locked two blood red eyes onto each of us. It’s nose had long since been turn off, exposing boney nostrils to the open air as it seemed to smirk. All across it’s body were the same symbols on the walls, in every cell… markings of death, of rebirth, of assimilation… From behind this seemingly Alpha emerges another figure I had never seemed before… dressed in a white cloak with a deer head.
"So they've followed the trail... they're too late" the Deer headed individual spoke, definitely not from here, a dialect similar to an Americans but... aristocratic? Each word was drawn out, assurance as if they had everything mapped down to our actions. They didn’t sound like they were from Poland or the east.
“Doesn’t matter…” the Alpha growled… and then, it lunged at us. Quickly breaking from their ground it slammed into my shield man knocking both him and myself at the ground as it displayed an intense feat of strength. Around us I could see several of the Strigoi leap at our comrades… though to no fruitful endeavor as I could see one GROM operator cut two down, as another got into a hand to hand confrontation… my breacher, crafty as they were, reached back and slammed one of the prybars of his kit into the skull of the beast.
The Alpha however was not content as it threw away the 90lb shield, sending it flying across the room as it grabbed my comrade by the skull. I quickly kicked up at it, firing my MK18 into it’s body as the rounds pierced it’s gray and rune covered flesh. The thing simply seemed to chuckle… that was until Major Krol blasted away at the side of it’s head, the alpha turned… and it’s smirk turned to a scowl when face to face with the major. A knowing pause almost like they had done this dance before…
The creature lunged, locking up with Major Krol as it swung and slammed railing. Krol didn’t back down however as he pushed against the creature, hiptossing it to the ground even as it tore at his armor and gear. But the beast pulled, both of them rolled and the Major was on his back as the thing reached for his neck. I fought to a kneel, firing into the creature messily with my MK18, trying not to hit my commander… then…
Click. A sound sends a chill up the spine of every warfighter during a firefight.
My gun ran dry. I dropped the magazine, looking to load another, but the thing came up and with one of it’s claws, sliced deep into my cheek, through the pro mask. I could feel my own blood go flying through the air as I landed hard on my back plate, spitting out red iron as I quickly tried to adjust my mask. Through my fogged up, blood covered lense… I saw my shield man raise his pistol, firing into the skull of the thing staggering it with a roar. Krol came from behind, drawing his knife he sunk it deep into the neck of it…. I reached for my rifle, forcing a new magazine in and damn near punching the bold release. ““Sir, down!!” I shouted, Krol rolled away, back to his own rifle as I fired. So did my comrade as he continued to fire his pistol… so did the Major as he fired his rifle. All of us chewing through that apex predator of darkness, that beast… the leader that had been preying on our people for so long. Layer by layer, muscle group by bone… eventually… the alpha landed on whatever was left of his back.
The silence of the fight died down as all of us checked our surroundings, GROM Operators putting controlled pairs in the heads and nerve stems of any Strigoi laying around… I flicked my weapon onto safe, letting it hang as I pulled off my mask. I dared not touch the wound on my face… the pain nearly crippling me if it wasn’t sheer will pushing me through, and adrenaline doing all it could to subdue it. The sound of the apaches continuing to lay hate drew us from our moment of contemplation as the Major went back to work; [“Confiscate any info, burn the rest…”]. He turned back to me as I shoved my damaged M50 mask back into it’s bag, chuckling as he looked at the sight; “You need a medevac, Blachowicz?” he quipped.
I shook my head, barely able to speak as I muttered; “Negative sir…”. The two of us scanned the room as my shield bearer went to collect his defense implement turned 90lb projectile, we scanned the center of the room, checking and confirming bodies, until we got to the last one alive. His white gown was soaked in red crimson and black ooze, as his dear head was mangled from bullet fire and impact from falling on it. I swear… the way his blood poured out of it though made me wonder if it was a mask. I gave it no second thoughts as he looked to Krol; “You… you can’t stop this, they’ve already-”.
The Major was in no mood for communication as his rifle snapped up and fired off three rounds to the body, four the head. The violent yet quick salvo ending the cultists life, I looked down at it, then to him as he remarked; “Have your squad drag him out to the front, burn the rest”. I stood alongside him, looking down as the sight of it’s deer head was both captivating and horrifying… the curiosity in me wanting to look closer at it fighting the primal instinct I had to burn the thing to ash. “-Haven’t seen one of those before…” I muttered, thinking the Major had an answer.
He didn’t. Krol saying “Neither have I…” shortly before he walked away, was what truly shook my soul about that entire night. Victory stood firm in our hearts that night as we stood outside of the bunker. The night sky burning with fire and white phosphorus as we watched the ruin burn from the inside from the other side of the lot. In the distance, the Apaches continued to scan and circle the forests, no longer firing…. Which meant they had driven any or turned to glass any enemy combatants within a four miles, probably both, more than likely the latter. Echo-1 patted me on the shoulder as we stood there, soaking it all in, though Krol looked none to pleased. “In the time it took us to take this one down, they’ll be trying to set up three more cells… that being established…” he said, looking to either of us, then to Echo-3. “-Hell of a thing we did tonight, been waiting for this one for a decade, cleanly, maybe more… but no time to rest on our laurels… we’ll have another task for us as soon as we’re boots down back home” he said, to which his eyes followed mine, the body of whatever cultist that was zipped up in a black body bag beside the wheel of one of the MRAPs. The fire from the bunker casting an orange hue over it’s shiny jet black outside, something didn’t sit right with me… “That wasn’t a Strigoi…” I said to Krol.
“That’s very clear…” the Major said, shoving his mask under his arm and lighting a cigarette. “So… someone’s helping them?” I asked. The meer notion of it shook me to my core, sickened me. This parasite was already badly infecting Europa, Polska… if it was spread like this throughout the world. Krol settled my nerves: “We’ll be ready… It’s not just us anymore”. As he said that, I realized what he meant… my eyes looking to the Apaches as they started to form up, leaving the areas as their thunderous propellers melted into the night’s calm, unnerving ambience.
It’s been a couple of weeks since then, Echo Detachment has been busy. We’ve gained good ground against the enemy and honestly I think in a few years, we might see a much larger change. For now… we must keep going, that being said the Strigoi aren’t the only ones we’ve been combating. Recently we’ve made contact with of some sort of extermination coalition, they’ve known about the Strigoi, and others plaguing the world, the level of corruption and corrosion on society goes deep. Regardless a lot of the units we’ve been working with are apart of NATO, such as this “4th Special Forces Group” of the American Military. I don’t know where the road from here leads, but we’ve gotten momentum on our side, finally. Just remember… these things are out there, in every town, every city, every nation… preying and waiting for you to be alone, vulnerable, so they can take you and replace you.
Watch your back, and stay safe.
For now, Blachowicz signing out. Until next time
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2024.05.14 21:49 wabisuki I broke my own rules.

Disclaimer: This is another one of my epic novels. Consider yourself warned.
Rule #1: Don't tell anyone at work. Rule #2: Don't write about work.
Somehow the boss and I got onto the topic of protein the other day... one thing lead to another... and before I could stop my lips, they spilled the tea. I at least managed to leave the MJ part out. Admittedly, it felt a bit like lying to the priest in the confessional (wouldn't be the first time that's happened)... except, this was on Zoom and we could see each other's faces.
Fortunately, I've lost enough weight now that the revelation was met with a raised eyebrow and a "WOW!" rather than the more typical.. "Really? Again? Until when? Lunchtime?". He's seen this rodeo before - more than a few times - so I really couldn't have blamed him if that would've been his response.
So far, he's been right EVERY. TIME.
And then he asked what my goal weight was. I should've known better.
"What? No! That's too much. You're such a big girl!"
Yes... Yes I am... but recent discoveries would indicate otherwise. (see my post EVERYDAY IS AN ADVENTURE for more information)
My goal weight is... ambitious.
While I would be the first to admit that my goal weight seems rather far fetched, based on my current weight. I didn't just pull it out of thin air. It was important to me that I set a goal that was anchored to something tangible - even if it seemed ambitious.
So, just before I started MJ in January 2024, I had a DEXA scan done. If you're not familiar with what a DEXA scan is, in the most simplest of terms, it's essentially a low radiation x-ray that scans your entire body and will calculate your body composition. You're provided with a report that will outline for you how much bone you have, how much lean mass you have (meaning muscle, connective tissue, organs, etc.), and how much fat you have. It takes it even one step further and provide a reasonable estimate of how much subaqueous fat you have (the annoying but tolerable fat) versus the amount of visceral fat you have (the evil fat twin you'd gladly give up for adoption).
So, knowing what my CURRENT lean body mass is under this fluffy quilt I walk around in, I could use that information to figure out what my "ideal" weight should be. How did I do that? Well, LEAN BODY MASS + 24% BODY FAT. Why 24%? Well, based on what I could estimate from guidelines online, 24% seemed to fit the mid-range of what would be considered 'healthy' for a woman of my age and height. So with a little basic math, I came to a number that is now my goal weight.
And yes, I'm perfectly prepared to settle on a much higher weight if, somewhere along this journey I discover a point where I'm actually comfortable in my own skin <-- Ha! Ha! That would be a first!
Plus, thanks to this subreddit, there is at least one person out there that started at a similar weight to me, same height as me, and is maintaining her weight within a range I had calculate. And she has the pictures to prove it! So, there is evidence that my end game is not entirely a made up fantasy. Thankfully, Cautious-Freedom-199 has been very open in sharing her personal journey, and it is her willingness and courage to share this part of herself that has made it possible for me to even imagine the possibilities.
So why am I having to defend myself?
Well, it's human nature.... and I have to keep reminding myself of that. Everyone will always have an opinion about something. We all do it. But what is important, is to recognize the intent. The intention, in this case, was not to harm me or ill will. Clearly, he has a point of reference, that he can relate to. And the number I stated, didn't align with his point of reference. And that's okay.
But still... suddenly I found myself having to justify my goal weight to him. A number, I'm not even convinced myself is based in reality. While I'm cautiously optimistic about the future, there's still a big part of me that has seated herself on the sidelines with her giant bowl of popcorn and strawberry twizzlers, keeping herself entertained with all of the replays of past colossal failures, while she waits, with eager anticipation, for the latest feature failure to premier.
My saving grace is that I'm a little bit of a nerd. I research the most mundane random curiosities, just for entertainment purposes - and also to help inform myself. Health, nutrition, weight loss all happen to be some of the mundane random curiosities I've obsessed over - for MANY YEARS. All in an effort to try and understand where all these little f*** fat cells came from, why they picked MY BODY of all places, and why every other cell in my body knows to DIE - skin cells die... brain cells die... muscle cells die... but for some reason, these fat little f*** fat cells convinced God to grant them eternal life. And with my luck, these little f*** will end up following me into the afterlife and I'll be fat there too - for eternity. My point is, when I find myself in situations like this, talking to someone who knows less about the topic at hand than I do... my super power is to literally bury them with information. More than they ever would want to know. And I don't stop, until they BEG me to.
Credibility is King!
If you're going to put any part of yourself out there, it pays to arm yourself with a few fun facts and have some tangible evidence to back up your rationalization, AND present in a way that is relatable to the personal your talking to. Nothing lends more credibility to what you're saying than sounding like the leading authority. In other words, it's hard to argue with someone who knows their shit. So when I explained how I came up with my goal weight, whether he agreed with it or not, it didn't matter. He could see that there was a methodology behind it, it was based on facts, and presented in a way that allowed him to understand there was strong logical evidence to support that number.
While this won't work in every situation - some people are just an ignorant stick in the mud - and you can't fix stupid, so don't waste your time even trying. Usually, if your audience is of reasonable intelligence and reasonably open-minded, and capable of having a respectful and rational discussion, then you at least have a fighting chance that they'll recognize that whatever your perspective is, has merit and isn't just complete bullshit. They may still chose to disagree - and that's okay. It's not your job to convince anyone that you're right and they're wrong. And so long as everyone agrees to respectfully disagree and leave it at that - there's nothing wrong with it.
Only time will tell....
He could actually be right.
I certainly don't know if I'm right.
And it doesn't matter.
But there are boundaries.
I did leave a key detail out of my discussion with him. Mounjaro. That was not by accident. And that's because I know there is a public perception of GLP-1 medications that is very misguided and misinformed and it is not a mountain I'm prepared to die on anytime soon. I don't know if he's even heard of these medications. It's quite possible he knows nothing about them. But it doesn't matter. This is a small detail I choose to keep close to my chest. Maybe, once I've reached my goal weight, I'll be more open about it. But no sooner than that, and it may well remain something that is on a 'need to know basis only' and most people won't ever need to know.
One thing I know for sure, and has proven itself time and time again, is that someone who has never had a significant weight problem their entire life CANNOT possibly relate to someone who has. They cannot process the distinction. They equate their struggles to lose 10-20-30 lbs to be the same as someone trying to lose 100-200-300 lbs. It's NOT the same. It's a different war on a different battle field with different rules. And I've learned that it's a losing battle to try and convince anyone just how different it is.
There was a podcast I recently watched on YouTube on PeterAttiaMD 's channel talking with Layne Norton. Layne explains why two people - one who has been lean their whole life - the other, fat their whole life - can both try to lose 20lbs and how the deck is stacked against the fat person vs. the lean person. I don't recall the specifics off hand and don't want misquote - but if this is of interest then maybe hunt through those interviews. If I can find it - I'll post it in the comments. But it was definitely an Aha! moment for me when he explained it. Sometimes, you hear someone explain the science and you suddenly feel vindicated.
So how did my conversation end with the boss?
Well, it ended with him asking me how many calories he should be eating per day, how much protein he should have, and then me calculating out his TDEE, caloric target, and macro ratios so that he can start on his own weight loss journey tomorrow. 😉
THE END.
< scroll credits >
submitted by wabisuki to Mounjaro [link] [comments]


2024.05.14 21:06 calorieconsciouscow supplements to reverse/help heal the skin & inner body from glycation, AGEs & inflammation due to years of sugary, carb rich diet?

hi, does anyone have any reccs regarding supplements that can reverse & aid in healing the damage caused by years of sh*tty diet
i know sugary food can age the body nearly 10x faster and i want to encourage new healthy cells to grow so my skin looks more vibrant & i feel much healthier
im many focused on collagen damage reversal and reproduction but i also need reccs for muscle, liver & gut damage
thanks
submitted by calorieconsciouscow to Supplements [link] [comments]


2024.05.14 18:43 AdInteresting2401 Mast cell activation syndrome (MCAS) - Interview with Prof. Dr. Knut Brockow

Mast cell activation syndrome (MCAS) is the subject of heated debate. How are mast cell activation syndromes defined? Which diseases are included? What is the diagnosis and treatment of mast cell activation syndrome? Prof. Dr. Knut Brockow, Clinic and Polyclinic for Dermatology and Allergology at the Biederstein, Technical University of Munich answers these questions in an interview with MeinAllergiePortal.
Mast cell activation syndrome: The most important facts!
-The prototype of mast cell activation syndrome is recurrent anaphylaxis
-Other forms of idiopathic mast cell activation syndrome are being sought; however, there are mainly symptom descriptions where the diagnosis cannot be made
-Clinical suspicion of MCAS is based on recurring allergy-like symptoms on the skin, nose, respiratory tract, gastrointestinal tract and circulation
-The diagnosis of MCAS is made according to recognized international criteria based on three criteria
-MCAS is often suspected even when symptoms are inappropriate and the diagnosis is unclear; the suspicion is then not helpful for patients
-The same medications are used to treat MCAS as are used to treat allergies, in particular antihistamines and cromoglicic acid
Prof. Brockow, what kind of disease is MCAS?
Mast cell activation syndrome is not an established diagnosis, but rather a concept. Historically, this concept arose because an increasing number of patients came to the doctor's office with complaints that gave the impression of having been triggered by mast cells. These patients sometimes showed symptoms similar to those of allergic reactions, anaphylaxis or mastocytosis, but a clear diagnosis for these diseases could not be made. Nevertheless, it was suspected that there could at least be a connection with mast cell diseases. Unfortunately, the term MCAS created more uncertainty than understanding. This is because MCAS is now thrown around as a diagnosis for many patients with many symptoms and an unclear diagnosis. This is not helpful for patients and fuels short-term hope of diagnosis and cure, which cannot be fulfilled later.
Is MCAS an autoimmune disease?
No, in autoimmune diseases mast cells are not primarily involved and not as lead cells, but lymphocytes that attack the body's own structures, in some cases by forming antibodies.
Is there a connection between mast cell activation syndrome and autoimmune diseases?
No, there is no known connection between MCAS and autoimmune diseases. It has also been claimed by specific authors that other diseases, such as Ehlers-Danlos syndrome, postural orthostatic tachycardia syndrome (POTS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) are related to mast cell activation syndrome. However, there are no good arguments for this. Unfortunately, such claims are easy to make and difficult to refute.
What is the cause of mast cell activation syndrome?
Mast cell activation syndrome is actually more of a symptom description than a diagnosis in its own right. Mast cell activation syndrome is fully applicable to recurrent anaphylaxis (severe allergic reactions in several organ systems such as the skin, respiratory tract, digestive tract and circulatory system), for example due to insect bites. All the criteria for mast cell activation syndrome are met here. Severe allergic reactions are the most common cause of MCAS. However, although the term MCAS is correct in this context, it does not provide any additional information, as patients with such events are better described as patients with a diagnosis of anaphylaxis or allergy, and the term MCAS is somewhat confusing.
Is mast cell activation syndrome genetic?
MCAS itself is not genetic, but patients with the genetic disease mastocytosis often suffer from anaphylaxis, particularly to insect venom, and therefore MCAS. In addition, it is currently being investigated whether people with genetically determined hereditary alpha-tryptasemia suffer more frequently from MCAS.
How did the term mast cell activation syndrome come about?
There were many patients without a clear diagnosis, some of whom predominantly showed the symptoms typical of mast cell diseases. Accordingly, the experts dealing with mast cell diseases saw the need to develop a concept that took into account the “undiagnosable” symptoms of the patients. In the course of this, the terms “mast cell activation” and “mast cell activation syndrome” were defined. In addition, an attempt was made to sort all mast cell diseases into a classification with regard to mast cell activation. However, the difficulty in classifying these complaints is that many of the complaints described by patients are subjective, relatively non-specific and can be both organic and psychosomatic.
How have you defined mast cell diseases and which diseases do they include?
Mast cell diseases are defined as recurring chronic symptoms that are compatible with mast cell activation.
Mast cell activation is classified on the basis of three criteria:
Recurrent typical clinical symptoms in at least two organ systems
An increase in mast cell mediators can be detected in the blood, most frequently by determining the serum tryptase level during an acute attack
Good response of symptoms to anti-mast cell mediator-directed therapy, especially H1 antihistamines
What types of mast cell disease are there?
The classification of mast cell diseases associated with mast cell activation syndromes defines three groups:
1. primary mast cell activation syndrome
Primary mast cell activation syndrome is explained by a clonal expansion of mutated overactive mast cells. It manifests as systemic or cutaneous mastocytosis. If these criteria are not completely fulfilled, but clonal mast cells have been detected, it is referred to as monoclonal mast cell activation syndrome.
2 Secondary mast cell activation syndrome
Secondary mast cell activation syndrome is present when clear triggers of mast cell activation are known. There are established terms for secondary mast cell activation syndrome that we are more familiar with, such as “anaphylaxis” to a known trigger. The classification in the second group of mast cell diseases is therefore merely a reclassification. Examples of mast cell activation are physical urticaria or cold urticaria. Allergies such as pollen allergies are also secondary mast cell activations, as hay fever also causes symptoms typical of mast cell diseases. In pollen allergies, mast cell mediators are found in the blood serum and drugs directed against mast cells have a good effect. If the symptoms recur in several organ systems, this is referred to as mast cell activation syndrome.
3. tertiary or idiopathic mast cell activation syndrome
Tertiary or idiopathic mast cell activation syndrome refers to mast cell diseases whose triggers are unknown. This group would include, for example, chronic spontaneous urticaria, which has additional symptoms in other organs. Here we know that mast cells are activated, but not by what. This group of idiopathic mast cell activation syndromes would also include patients with as yet undescribed clinical pictures who do not fulfill the diagnostic criteria of known mast cell diseases, e.g. allergy, anaphylaxis, but in whom the disease is triggered by mast cells. In these patients, however, the connection between the symptoms and the activities of the mast cells must be proven.
Does this mean that tertiary or idiopathic mast cell activation syndrome is a diagnosis of exclusion?
Idiopathic mast cell activation syndrome can be described as a diagnosis of exclusion insofar as the prerequisite for the diagnosis is that there is no other disease causing the symptoms. However, the symptoms described are often very, very unspecific and could also be caused by a variety of other diseases. However, there are the three criteria for mast cell activation syndrome already mentioned. If these are not all fulfilled, this diagnosis cannot be made.
How common is mast cell activation syndrome?
Anaphylaxis and severe recurrent allergies are not uncommon and represent the vast majority of appropriate cases for MCAS. In addition, mastocytosis patients often have multiple anaphylaxis and therefore also MCAS. However, our initial idea of finding a new disease, idiopathic mast cell activation syndrome, has not yet been confirmed. There are many patients with many symptoms for whom a clear organic diagnosis cannot yet be made. However, it is almost never possible to prove that a defect in the mast cells is primarily responsible for the symptoms. Many of these patients describe symptoms that could fit, and in some patients anti-allergic drugs also have a positive effect. But in only very few patients can an increase in mast cell mediators be detected during an acute attack. I now believe that somatic stress disorders could play a significant role in many of the patients examined.
Histamine intolerance is also a diagnosis of exclusion, is there a connection with mast cell activation syndrome?
Histamine intolerance can cause similar symptoms, but is not a mast cell disorder and has nothing to do with MCAS. When mast cells are activated, the messenger substance histamine is released, which in turn can cause symptoms. In histamine intolerance, the mast cell is not activated - it is not involved in any way. Rather, histamine intolerance describes patients with an increased sensitivity to histamine, which is supplied, for example, via the diet. This can lead to similar symptoms, but in contrast to mast cell activation syndrome, histamine intolerance has a clear trigger, histamine. As a result, the symptoms occur after eating histamine-rich foods, but disappear again if the patient follows a low-histamine diet. A test is also available to diagnose histamine intolerance.
So there are also patients with suspected mast cell activation syndrome who cannot be assigned to a classification group, even though they have corresponding symptoms?
There are many patients in whom no mast cell activation syndrome can be detected despite suspicion. They do not fit into one of the three groups. However, this also used to include monoclonal mast cell activation syndrome. These patients showed anaphylaxis and a KIT mutation, but not the full criteria for mastocytosis. In the meantime, a separate disease diagnosis has been created for these patients. The independent accepted disease of these patients therefore lies between mastocytosis and normal findings.
We thought that there might be other forms of idiopathic MCAS with clinical pictures that have not yet been described. However, this is not supported by the findings to date. There are patients who show symptoms but do not meet the necessary criteria for idiopathic mast cell activation syndrome. In these patients, the diagnosis remains unclear. In how many of these patients functional physical complaints play a role still needs to be investigated.
Are there risk factors that favor mast cell activation syndrome?
There are hardly any recognized studies on this. In a study conducted by Cem Akin in the USA, patients were examined who met the three criteria for idiopathic mast cell activation syndrome. They had the right symptoms, there was an increase in mediators and their symptoms improved with treatment. It was shown that many of these patients suffered from urticaria factitia, a scratch-induced urticaria, abdominal pain and flushing.
Recently, a genetic trait was discovered, hereditary alpha-tryptasemia with elevated basal serum tryptase levels. In patients with this trait and insect venom allergy, the severity of the allergic reaction appears to be increased. It is also discussed that the frequency of mast cell activation syndrome is increased in patients with this genetic trait. However, the published studies are not yet unanimous in this respect.
What symptoms can occur with MCAS?
The following symptoms could be signs of mast cell activation syndrome:
MCAS symptoms on the skin:
Appearance of sudden intense redness (flushing)
itching
wheal formation
Deep wheal formation (angioedema or Quincke's edema)
MCAS symptoms on the nose:
Nasal congestion
Nasal itching
MCAS symptoms in the airways:
Swelling of the upper airways
Wheezing
Shortness of breath
MCAS symptoms of the digestive tract:
Vomiting
abdominal pain
diarrhea
Systemic MCAS symptoms:
Syncope - where you suddenly lose consciousness, but only for a short time
Sudden drop in blood pressure
Allergic shock
These symptoms can occur together or individually. In principle, symptoms must occur in two or more organ systems for MCAS. These symptoms, together with the typical skin changes and anaphylaxis, are also typical of mastocytosis.
Are muscle pain and hair loss also symptoms of MCAS?
No, why would anyone think that these symptoms are primarily caused by a malfunction of mast cells? Mast cells are not important cells for muscle pain and hair loss.
How is MCAS diagnosed?
MCAS is a diagnosis of exclusion, i.e. there is no mast cell activation syndrome test. However, this does not mean that all other diseases must be ruled out before a diagnosis of MCAS can be made.
When testing directly for mast cell activation syndrome, three criteria would be examined, all of which must be met, not just two:
First, there must be a matching of symptoms to see if the above symptoms are leading, recurrent and occur in at least two organ systems.
Is there a substantial or complete improvement in the clinical symptoms when taking anti-allergic medication, antihistamines or cromoglicic acid? Then this criterion would apply.
The blood levels of tryptase in the serum can now be examined at two different points in time. This would check whether there is an increase in mast cell mediators or tryptase in the blood serum in a highly symptomatic phase or during a seizure compared to a time when there are no symptoms.
What does the tryptase level in the blood mean in the diagnosis of mast cell activation syndrome?
If the mast cell mediator tryptase rises by 20 percent of the basal value, i.e. the initial value, + 2 ng/ml during such an episode, the diagnosis of mast cell activation syndrome has been made without the need to rule out other diseases beforehand. However, taking blood samples to determine the tryptase levels is very time-consuming, because a blood sample should be taken in the normal state and then another blood sample should be taken during a seizure or a highly symptomatic episode. This means that the patient must see a doctor in good time for a blood test during the acute phase. If these tests are negative, mast cell activation syndrome cannot be confirmed.
Elevated tryptase levels also play a role in anaphylaxis, is there a connection with mast cell activation syndrome?
Anaphylaxis is an extremely strong mast cell activation, the “prototype” of mast cell activation, so to speak. The tryptase level rises, so that it is considered an indicator of anaphylaxis. Here too, the basal value is measured and compared with the value during an episode. The relevant factor is the resulting increase in the tryptase value. The therapy against mast cells is effective in this case. In this respect, anaphylaxis is the classic form of mast cell activation syndrome.
The tryptase value also plays a role in the diagnosis of mastocytosis, what are the correlations here?
Mastocytosis patients also have an elevated baseline tryptase level. This is therefore an indication of mastocytosis and an indication for a final diagnosis by means of a bone marrow biopsy. However, there is also a mastocytosis-independent correlation between tryptase and anaphylaxis. People who have a higher number of mast cells often develop more severe anaphylaxis than people with fewer mast cells. The tryptase basal value is therefore considered a kind of indicator for the total mast cells in the body. For example, insect venom anaphylactic patients with elevated basal mast cell tryptase levels in the blood are at increased risk of severe anaphylaxis.
What can be done against MCAS and which medications help?
The aim of treatment for mast cell activation syndrome is to slow down the effect of the overactivated mast cells and to calm the mast cells. In particular, the avoidance of allergic triggers is available for this purpose.
Histamine receptor blockers are tried as medication to block the effects of mast cell activation by histamine. Mast cell stabilizers or blockers of mast cell release, cromoglicic acid, can also calm the mast cells. Cromoglicic acid is also used in mastocytosis patients. It is important to know that the use of cromoglicic acid is not advisable if the attack has already run its course. On the other hand, many patients achieve a significant improvement in symptoms if cromoglicic acid is taken continuously as a preventive measure and in a sufficiently high dose. This has also been shown to be the case with antihistamines.
Another option would be leukotriene receptor antagonists and corticosteroids in the short term, but never over a longer period of time.
Unfortunately, many patients with previously unexplained complaints are given a suspected diagnosis of MCAS in the hope that this knowledge will lead to better treatment or perhaps a cure. However, apart from the drugs mentioned, which can also be used on a trial basis in cases of suspected MCAS, there are no other useful drugs available. In this respect, the suspicion of MCAS unfortunately does not offer patients any additional treatment options.
Are there foods that activate or deactivate mast cells?
No such foods are known in humans. Of course, it is possible to bombard mast cells in a test tube with high concentrations of food and measure whether the natural activation of mast cells is increased or reduced. However, such tests are generally not meaningful for humans when consumed.
Can naturopathy help with mast cell activation syndrome?
I don't know how it could help. Naturopathy is the attempt to achieve a positive effect through naturally occurring active substances. Is the avoidance of allergens in our natural environment already naturopathy?
Could certain vitamins, for example vitamin C, be beneficial for MCAS?
This is claimed by a few doctors without any convincing results. Vitamin C is also said to help against seasickness. After all, vitamin C, taken in normal amounts, is not harmful and is beneficial. Sometimes the conviction that a substance is good for you also helps. That's why the experiment doesn't bother me.
Is it possible to prevent mast cell activation syndrome?
Yes, by avoiding MCAS with a known trigger. This is the case with allergies. In the case of allergies and recurrent anaphylaxis as a form of MCAS, omalizumab, an antibody against immunoglobulin E, can also be used in individual patients.
Prof. Brockow, thank you very much for this interview!
https://www.mein-allergie-portal.com/mastozytose-mastzellaktivierungssyndrom-mcas/925-idiopathisches-mastzellenaktivierungssyndrom-ein-neues-krankheitsbild.html
submitted by AdInteresting2401 to MCAS_ [link] [comments]


2024.05.14 16:35 Budget_Treat_6776 Planet Zelo: Zelorix Species information.

Zelorixians
Kingdom: Zeloriaria
Phylum: Auroriformes
Class: Zelorixia
Order: Harmoniida
Family: Aurorifidae
Genus: Zelorix
Species: Z. aurorix
(Anatomical Structure)
(Sensory features)
(Physical Abilities/Lifespan)
(Intelligence)
Vocal Chord Structure: The Zelorix’s vocal cords are arranged in a golden spiral pattern, with 12 muscles controlling the cords to produce a wide range of frequencies and harmonics. The vocal cords themselves are divided into 8 segments, each with a length that follows the Zelorifour Sequence’s golden ratio proportion (0.9618:0.0382). This unique structure allows the Zelorix to produce a vast array of sounds, from melodic tones to complex vocalizations.
(Eye Sight)
The Zelorix’s eyes are capable of perceiving a wide range of wavelengths, from infrared to ultraviolet light. Its eyes are structured in a golden rectangle pattern, with each eye containing 20 tiny sensors arranged in a golden spiral pattern, following the Zelorifour Sequence’s golden ratio proportion (0.9618:0.0382). This allows the Zelorix to detect subtle changes in its environment and perceive its surroundings with exceptional clarity. The Zelorix’s eyes are also capable of moving independently, allowing it to track multiple objects or targets simultaneously, with a tracking speed of approximately 0.9618 times the square root of its total number of sensors (20).
(Visual Perception)
(Vocal Range)
Ocular Structure: The Zelorix’s eyes are composed of the following structures, all of which are arranged in a golden rectangle pattern, following the Zelorifour Sequence’s golden ratio proportion (0.9618:0.0382):
  1. Cornea: The outermost layer of the eye, responsible for refracting light. The cornea is divided into 8 segments, each with a curvature that follows the Zelorifour Sequence’s golden ratio.
  2. Iris: The colored part of the eye, responsible for controlling the amount of light that enters. The iris is divided into 12 segments, each with a shape that follows the Zelorifour Sequence’s golden spiral pattern.
  3. Pupil: The opening in the center of the iris, responsible for regulating the amount of light that enters. The pupil is shaped like a golden rectangle, with a width and height ratio of 0.9618.
  4. Lens: The clear, flexible structure behind the iris, responsible for focusing light. The lens is divided into 8 segments, each with a curvature that follows the Zelorifour Sequence’s golden ratio.
  5. Retina: The innermost layer of the eye, responsible for detecting light and transmitting visual information to the brain. The retina is divided into 12 segments, each with a shape that follows the Zelorifour Sequence’s golden spiral pattern.
  6. Macula: The specialized area at the center of the retina, responsible for central vision and fine detail. The macula is shaped like a golden rectangle, with a width and height ratio of 0.9618.
  7. Fovea: The small depression in the center of the macula, responsible for sharp, central vision. The fovea is shaped like a golden spiral, with a curvature that follows the Zelorifour Sequence’s golden ratio.
The Zelorix’s ocular structure is designed for maximum visual acuity and clarity, with each component working in harmony to produce exceptional visual perception, following the Zelorifour Sequence’s mathematical principles.
(Brain Structure) - The Zelorix’s brain is divided into 12 segments, each with a unique function and connected in a golden spiral pattern, following the Zelorifour Sequence’s golden ratio proportion (0.9618:0.0382). - The brain-to-body mass ratio is approximately 0.9618, indicating a highly efficient and advanced cognitive system. - The cerebral cortex is divided into 8 layers, each with a specific function, such as sensory processing, memory, and decision-making, with each layer’s thickness and structure following the Zelorifour Sequence’s golden ratio.
Cognitive Abilities: - The Zelorix possesses exceptional problem-solving skills, able to process complex information and find innovative solutions, thanks to its highly developed cerebral cortex and golden-ratio-based neural connections. - Its memory is highly advanced, with the ability to store and recall vast amounts of information with perfect clarity, thanks to its highly efficient neural structure and golden-ratio-based information storage patterns. - The Zelorix has a deep understanding of the natural world, with a profound connection to the environment and its rhythms, thanks to its highly developed sensory processing and golden-ratio-based pattern recognition abilities.
Skin and Dermal Structure: - The Zelorix’s skin is composed of 12 layers, each with a unique function, such as protection, sensation, and regulation, with each layer’s thickness and structure following the Zelorifour Sequence’s golden ratio. - Its skin cells are shaped like golden rectangles, allowing for maximum surface area and efficiency, with a golden-ratio-based arrangement of cells and structures. - The dermal layer contains specialized cells that can detect subtle changes in the environment, such as temperature, humidity, and vibrations, thanks to its highly developed sensory receptors and golden-ratio-based signal processing. - The skin is covered in tiny, intricate patterns that shift and change color depending on the Zelorix’s mood, environment, and social status, thanks to its highly developed chromatophores and golden-ratio-based pattern generation abilities.
(Muscular System)
(Respiratory System)
(Digestive System) - The Zelorix’s digestive system consists of 8 segments, each with a unique function and connected in a golden spiral pattern, following the Zelorifour Sequence’s golden ratio. - Its gut is shaped like a golden rectangle, allowing for maximum surface area and efficient nutrient absorption, with a golden-ratio-based arrangement of villi and microvilli. - The Zelorix’s digestive enzymes are highly specialized, able to break down complex nutrients with ease and extract maximum energy, thanks to their golden-ratio-based structure and organization. - Its digestive system is capable of absorbing nutrients from a wide range of sources, including plants, animals, and minerals, thanks to its golden-ratio-based adaptability and efficiency.
(Immune System)
(Reproductive System)
(Nervous System)
(Neural Structure)
(Sensory Processing)
(Bone Structure)
Male Zelorixians:
Female Zelorixians:
Eye Color:
Hair Color:
Male Zelorix:
Female Zelorix:
Physical Strength:
Energy Levels:
View Poll
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2024.05.14 14:01 Zappingsbrew A post talking about 400 words

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palm, pan, panel, panic, pant, paper, paragraph, parent, park, parking, part, participant, participate, participation, particle, particular, particularly, partly, partner, partnership, party, pass, passage, passenger, passion, past, patch, path, patient, pattern, pause, pay, payment, PC, peace, peak, peer, pen, penalty, people, pepper, per, perceive, percentage, perception, perfect, perfectly, perform, performance, perhaps, period, permanent, permission, permit, person, personal, personality, personally, personnel, perspective, persuade, pet, phase, phenomenon, philosophy, phone, photo, photographer, phrase, physical, physically, physician, piano, pick, picture, pie, piece, pile, pilot, pine, pink, pipe, pitch, place, plan, plane, planet, planning, plant, plastic, plate, platform, play, player, please, pleasure, plenty, plot, plus, PM, pocket, poem, poet, poetry, point, police, policy, political, politically, politician, politics, poll, pollution, pool, poor, pop, popular, population, porch, port, portion, portrait, portray, pose, position, positive, possess, possession, possibility, possible, possibly, post, pot, potato, potential, potentially, pound, pour, poverty, powder, power, powerful, practical, practice, prayer, preach, precisely, predict, prediction, prefer, preference, pregnancy, pregnant, preparation, prepare, prescription, presence, present, presentation, preserve, president, presidential, press, pressure, pretend, pretty, prevent, previous, previously, price, pride, priest, primarily, primary, prime, principal, principle, print, prior, priority, prison, prisoner, privacy, private, probably, problem, procedure, proceed, process, processing, processor, proclaim, produce, producer, product, production, profession, professional, professor, profile, profit, program, progress, progressive, project, prominent, promise, promote, prompt, proof, proper, properly, property, proportion, proposal, propose, prosecutor, prospect, protect, protection, protein, protest, proud, prove, provide, provider, province, provision, psychological, psychology, public, publication, publicity, publish, publisher, pull, punishment, purchase, pure, purpose, pursue, push, put, qualify, quality, quarter, quarterback, quarterly, queen, quest, question, quick, quickly, quiet, quietly, quit, quite, quote, race, racial, radiation, radical, radio, rail, rain, raise, range, rank, rapid, rapidly, rare, rarely, rate, rather, rating, ratio, raw, reach, react, reaction, reader, reading, ready, real, reality, realize, really, reason, reasonable, recall, receive, recent, recently, reception, recipe, recipient, recognition, recognize, recommend, recommendation, record, recording, recover, recovery, recruit, red, reduce, reduction, refer, reference, reflect, reflection, reform, refugee, refuse, regard, regarding, regardless, regime, region, regional, register, regular, regularly, regulate, regulation, regulator, reinforce, reject, relate, relation, relationship, relative, relatively, relax, release, relevant, relief, religion, religious, rely, remain, remaining, remarkable, remember, remind, remote, remove, repeat, repeatedly, replace, replacement, reply, report, reporter, represent, representation, representative, Republican, reputation, request, require, requirement, research, researcher, resemble, reservation, resident, residential, resign, resist, resistance, resolution, resolve, resort, resource, respect, respond, response, responsibility, responsible, rest, restaurant, restore, restriction, result, retain, retire, retirement, return, reveal, revenue, review, revolution, rhythm, rice, rich, rid, ride, rifle, right, ring, rise, risk, river, road, rock, role, roll, romantic, roof, room, root, rope, rose, rough, roughly, round, route, routine, row, rub, rubber, rude, ruin, rule, run, running, rural, rush, Russian, sacred, sad, safe, safety, sake, salad, salary, sale, sales, salt, same, sample, sanction, sand, satellite, satisfaction, satisfied, satisfy, sauce, save, saving, say, scale, scandal, scare, scatter, scenario, scene, schedule, scheme, scholar, scholarship, school, science, scientific, scientist, scope, score, scream, screen, script, sea, search, season, seat, second, secondary, secret, secretary, section, sector, secure, security, see, seed, seek, seem, segment, seize, select, selection, self, sell, Senate, senator, send, senior, sense, sensitive, sentence, separate, sequence, series, serious, seriously, servant, serve, service, session, set, setting, settle, settlement, seven, several, severe, sex, sexual, shade, shadow, shake, shall, shallow, shape, share, sharp, she, sheet, shelf, shell, shelter, shift, shine, ship, shirt, shock, shoe, shoot, shooting, shop, shopping, short, shortly, shot, should, shoulder, shout, show, shower, shrug, shut, shy, sibling, sick, side, sigh, sight, sign, signal, significant, significantly, silence, silent, silver, similar, similarly, simple, simply, sin, since, sing, singer, single, sink, sir, sister, sit, site, situation, six, size, ski, skill, skin, skirt, sky, slave, sleep, slice, slide, slight, slightly, slip, slow, slowly, small, smart, smell, smile, smoke, smooth, snap, snow, so, so-called, soccer, social, society, soft, software, soil, solar, soldier, sole, solid, solution, solve, some, somebody, somehow, someone, something, sometimes, somewhat, somewhere, son, song, soon, sophisticated, sorry, sort, soul, sound, soup, source, south, southern, Soviet, space, Spanish, speak, speaker, special, specialist, species, specific, specifically, specify, speech, speed, spend, spending, spin, spirit, spiritual, split, spoil, sponsor, sport, spot, spray, spread, spring, square, squeeze, stability, stable, staff, stage, stain, stair, stake, stand, standard, standing, star, stare, start, state, statement, station, statistical, status, stay, steady, steal, steel, steep, stem, step, stick, still, stimulate, stimulus, stir, stock, stomach, stone, stop, storage, store, storm, story, straight, strange, stranger, strategic, strategy, stream, street, strength, strengthen, stress, stretch, strike, string, strip, stroke, strong, strongly, structural, structure, struggle, student, studio, study, stuff, stupid, style, subject, submit, subsequent, substance, substantial, substitute, succeed, success, successful, successfully, such, sudden, suddenly, sue, suffer, sufficient, sugar, suggest, suggestion, suicide, suit, summer, summit, sun, super, supply, support, supporter, suppose, supposed, Supreme, sure, surely, surface, surgery, surprise, surprised, surprising, surprisingly, surround, survey, survival, survive, survivor, suspect, sustain, swear, sweep, sweet, swim, swing, switch, symbol, symptom, system, table, tactic, tail, take, tale, talent, talk, tall, tank, tap, tape, target, task, taste, tax, taxi, tea, teach, teacher, teaching, team, tear, technical, technique, technology, teen, teenager, telephone, telescope, television, tell, temperature, temporary, ten, tend, tendency, tennis, tension, tent, term, terms, terrible, territory, terror, terrorist, test, testimony, testing, text, than, thank, thanks, that, the, theater, their, them, theme, themselves, then, theory, therapy, there, therefore, these, they, thick, thin, thing, think, thinking, third, thirty, this, those, though, thought, thousand, threat, threaten, three, throat, through, throughout, throw, thus, ticket, tie, tight, time, tiny, tip, tire, tissue, title, to, tobacco, today, toe, together, toilet, token, tolerate, tomato, tomorrow, tone, tongue, tonight, too, tool, tooth, top, topic, toss, total, totally, touch, tough, tour, tourist, tournament, toward, towards, tower, town, toy, trace, track, trade, tradition, traditional, traffic, tragedy, trail, train, training, transfer, transform, transformation, transition, translate, translation, transmission, transmit, transport, transportation, travel, treat, treatment, treaty, tree, tremendous, trend, trial, tribe, trick, trip, troop, trouble, truck, true, truly, trust, truth, try, tube, tunnel, turn, TV, twelve, twenty, twice, twin, two, type, typical, typically, ugly, ultimate, ultimately, unable, uncle, undergo, understand, understanding, unfortunately, uniform, union, unique, unit, United, universal, universe, university, unknown, unless, unlike, until, unusual, up, upon, upper, urban, urge, us, use, used, useful, user, usual, usually, utility, utilize, vacation, valley, valuable, value, variable, variation, variety, various, vary, vast, vegetable, vehicle, venture, version, versus, very, vessel, veteran, via, victim, victory, video, view, viewer, village, violate, violation, violence, violent, virtually, virtue, virus, visibility, visible, vision, visit, visitor, visual, vital, voice, volume, voluntary, volunteer, vote, voter, voting, wage, wait, wake, walk, wall, wander, want, war, warm, warn, warning, wash, waste, watch, water, wave, way, we, weak, weakness, wealth, wealthy, weapon, wear, weather, web, website, wedding, week, weekend, weekly, weigh, weight, welcome, welfare, well, west, western, wet, what, whatever, wheel, when, whenever, where, whereas, whether, which, while, whisper, white, who, whole, whom, whose, why, wide, widely, widespread, wife, wild, wildlife, will, willing, win, wind, window, wine, wing, winner, winter, wipe, wire, wisdom, wise, wish, with, withdraw, within, without, witness, woman, wonder, wonderful, wood, wooden, word, work, worker, working, workout, workplace, works, workshop, world, worried, worry, worth, would, wound, wrap, write, writer, writing, wrong, yard, yeah, year, yell, yellow, yes, yesterday, yet, yield, you, young, your, yours, yourself, youth, zone.
submitted by Zappingsbrew to u/Zappingsbrew [link] [comments]


2024.05.14 12:29 NoBarracuda2587 Chronicles of Silentverse: The Secret Files 3

File Sequence: <Beginning> -First Contact[10]- -Conclusion- <Legends>
_______________________________
<Archives>
_______________________________
Secret Files: <CoS[1]> -Cos[2]-
...
...
...

Devouring Cancer

________________________________________________________________________________
Meat. /mi:t/
Me it. /mi/ /:t/
It me. /:t/ /mi/
It’s me…
We are eating ones of ourselves…
________________________________________________________________________________
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/C̶̢͈̈̂͒̀̋̾̓͌Ô̶̻͉̠̱͈̳̮N̸̫̹̱̯̣̣̻̐̽͒̎̃̆̕͜Ǹ̴̛̛͙̫̇E̴͕̮̻͇̒͐̀C̶̳̤̠͔̺̚T̴̘̑̈́̂͛̂̏E̶̡̩̝̮͇̤̣̋̏͗D.
/Mellator Matrix Mind: Inner Core.
/Unit: great [AVALON] the first
/G.R. Era.
/Memory File transmission: Generalized perspective
/Gender: N/A[Neutral]
/Age: {Human equivalent: 2001 years}
/Race: Grrrr’atrrr
/Species: N/A[Hive Mind]
/ Additional verification: Class>>> [Cancer Cells]
/Cradle planet: Ci-3301
/Home planet origin: Mupan
/First person POV not applicable. Generalized Spectator mode.
/Sequence Code: 5-18-5-8 19-1-23 20-8-7-9-14-11-5-12-2-13-21-8
/Memory transmission in 3…2…1…
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Hunger…
It’s all that drives us. It’s all that unites, connects us… All that pulls us, all that defines and binds us…
Our story began long ago. It all started with a single parasite cell. Not the greatest primordial ancestor indeed, but every Apex Predator started somewhere. But back to our history… That very first cell was our first grandmother, as well as the beginning of our entire civilization. Hard to tell what was the trigger for it’s evolutionary change, as time wipes all. Perhaps it was desire to become something better? Awakening? Or maybe just spontaneous mutation in one of the genome chains, occurring by changes in environment? It really doesn’t matter. All what matters is that that cell evolved…
It didn’t happened quickly of course. Our first grandmother was no different than an average cancer cell that is present in nearly every life form, even us. It just growed into one small neoplasm, or simply, a cancer tumor. But that tumor slowly made it’s way to the brain. We know that because that’s how we, as well as our ancestors, assimilated everything for millennia…
It is impossible to determine which one of the prey species was honored to become the meal of our first ancestor, but it was clear that that feast was something that never happened before. That tumor did not just sucked the nutrients dry till the brain dies from the protein starvation, taking the tumor along the way with it. No, that tumor assimilated it. And that tumor learned. Learned from it. And it saw the world for the first time.
Assimilation is not as easy as other inferior beings think. First, your cell needs to find the prey cell. Then it needs to envelop the cytoplasm of that cell to properly assimilate it. However, after assimilating the “Host”, your cells need to take properties of assimilated cells and even function for the prey organism for the time being so it won’t suspect anything. It is a long, tedious and fatiguing process. That’s why we just ambush other prey organisms, tear them apart, and devour them for protein supplies, to avoid all that bustling.
And say what, the prey doesn’t make it easier for us either. As our first ancestors quickly learned, prey can be sentient too. It is inferior, weak, pathetic… And yet it can create great weapons to stop us. For [decades] these beings create astonishing amount of that pesky, venomous and disgusting antibiotics and chemicals to kill our minds. For thousands of [years] they set our flesh on fire, making us scream as we die in agony cell by cell.
And yet we prevail. When they make those chemistry compounds they call “Cure”, we gain immunity to it. When they set our bodies ablaze, we spray them with our blood and teeth, making their bodies to slowly blister as we eat them inside out. When they close their doors on us, we use ventilations, slithering right above their heads or below their {feet}. When they use special protection suits, we just tear them apart. And when they completely quarantine themselves, thinking that they are safe, we pretend to be one of them, striking from behind…
What is the most amazing thing about this prey? Well, aside that their flesh is delicious… They are clever. And they know how to build stuff. Weapons, tools, technology… Everything to increase the odds of survivability and comfort of their pathetic kind. And by devouring their minds, we gain all this knowledge as well! We learned how to grow cattle to saturate our hunger, we learned how to create faster means of transportation that even the fastest members of our swarm can’t out-crawl with their appendages. And most importantly; we learned how to reach the skies…
Among the prey species that we feast upon, there was a special class, or caste, of highly educated specimens, who called themselves “scientists”. These specimens learned how to use metal, fuel, radiation, and other inedible and in some cases straight up harmful components of nature, and turned them into what they called “Spacecraft”. A special vehicle, capable of leaving the atmosphere of our planet. Something that sounded like fantasy, even for the boldest ones of us, who sometimes managed to grow wings and flew high in the sky. It was a fantasy until we consumed their heads and the knowledge they possessed along the way. From them we gained knowledge of the schematics of these space vessels, and most importantly; the schematics of FTL drives. Devices capable of traveling among the stars with “superluminal” speed. And so, after conquering and discovering each and every corner of our planet, we soared to the great unknown, right into the void…

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/Transmission mode: Spectator. Centralized perspective.
/Subject: Verrruur. Grrrr’atrrr. Lead hive mind of the Hunter Fleets.
/Transmission in 3…2…1…
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We flew among the stars in our glorious ships made out of strongest titanium fusions and covered in our eternal flesh. Yes, what wasn’t made out of the metal hulls and electronics, was made out of sheer muscles and flesh tissue. So many cells… So much nutrition… We could withstand decades without the food and still hunt like our greatest hunters back on Mupan(Apparently, that’s how prior sentient prey species happened to call our planet, and we didn’t really bother to rename it, as for us it was widely known as just plain“Ground, floor, or land”). Our strongest weapons, combined with our most dissolving acid spitters, made us the strongest and most feared hunters, “cementing” our history as the strongest Apex Predators in the galaxy! We defeated, devoured, and assimilated everything… It did not matter if our enemy was a leviathan, an enemy prey fleet, or even an entire planet. If it could be eaten, it was eaten…
Until it wasn’t…
On yet another great crusade in search of delicacy for our insatiable fleets, our sensors captured a strange, but nonetheless familiar signal. The impulse of FTL drive. We made a serious double, and even triple checking of our radars to avoid a major nutritional loss due to false readings. After our intels captured, properly verified, and confirmed the signal, our intercoms just exploded with thousands of jaws:
“Food?”
“Food…”
“ Food! FOOD!!! Food! Food! Delicious prey! Food! We shall… FEAST! Food! Yes!!! Food! FOOD!!! We haven’t ate for [Month]! At last… Some good food… Food! Juicy food… Flesh of prey…
Food! The succulent meat…”
Yes, we felt joy. And anticipation of hunting down these unknown but likely very delicious organisms. It was like opening the present. You don’t know what was inside these flying metal cans, but you sure know that it was likely to be something edible.
Oh, we never were so wrong in our glorious history.
We did not saw them at first, that’s how black and cloaked they were. When we finally identified our “prey” we saw it was a small cluster of black ellipsoids, just hovering there. They did not tried to contact us, like other naive prey organisms did. They were completely silent...
“We will smash you like the eggs you are!” we foolishly thought back then...
They slowly turned frontwards when we approached them. Their range was astonishing, picking our smallest drones instantly before they could even scream, like if they were the candles that these black horrors just blew out.
When we finally reached the required distance and fired our acid sacks and laser guns however, they were still there, not blowing up, retreating, or even moving an [inch]. Then we opened all the airlocks(if we weren’t already outside) and enveloped their ships in our mighty grip, not stopping to pour their shields with our acids and plasma. Usually, after a few unpleasant zaps of enemy shields, they just popped and the ships just were crack open like the [nuts].
But not them...
They did not crumble and exposed their hulls with screaming prey just getting sucked out in the vacuum as usual, no, instead they started to grow bright red. Redder than our flesh and blood…
And burned. Burned stronger and more painful than any flame. Our drones roared in pain but we couldn’t hear any of their songs of torture in this vacuum of silent space. Hundreds of megatons of our flesh clusters was just turned in ashes or were torn off and become drifted dead lumps of burnt meat. Our intercoms filled with screams of fear and agony, our minds losing their mass and density, turning into undeveloped children.
"Father? It hurts…” could be heard from countless drones. And any of them that tried to escape, were sniped with red beams of such accuracy, that our best spitters could only dream of. It didn’t last long when we were the only operating guide ship of entire Armada that was so ingloriously butchered. And then we felt the warmth…
No… NO!
All weapons of this black "eggs" were pointed at us, our last mind. The last memories flashed as we slowly were burned to death. The last though of our last tumor was the realization that there was someone stronger than us. Someone who cannot be eaten. The bigger Predator…
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/Memory transmission File disconnected.
/Reason: Biological death of the Subject.
/Cause of death: Sterilization.
/End of data log.
/D̵̛̤̂͜I̵̢͎̬̍̄̂͌͋S̴̢̛̙͇̯̽̔̾́͝C̸̭͓̰̤͋͆́ͅÓ̴͖̜̯̻͂̃̉N̵̨̧̦͙̳̍̾̕N̴͙̬͓̽̃̂̇͂͝E̵̠̬̠͉͒C̵̢̛͚̪̭̭̼̿̎T̶̝̈́͋͘͜Ì̸̢̱̙̤̽͑̽̈́̍ͅŌ̵̗̬̑̍̽̒N̷͖͖̗̗͚͈͗͛...
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submitted by NoBarracuda2587 to HFY [link] [comments]


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