Mutated dna copy

artificial super organs a personal preferred method of modification we have taken the first steps to achieving this but not the last. the user ChikyChikyBoom already brought the facts of ronit freeman and her colleagues literally building cells from the ground to this reddit up so i wont go into to much detail on it. but this is only the beginning since we now have the programmable peptide-DNA tech to make cells. with proper evolution of the tech and aproptriot funding making a redesigned cell with modified dna from the intended host will likly be made sooner then later.
why simple the synthetic cells could be modified to take to bioprinting much better then nateral cells (mammal cells dont take to well to growing in a vat then printed into an organ) so likly this will be the very first mod. after thats normalized likly someone will ask why stop at making copys of the old design why not make a better one. then it spirals out from there id say 10 to 15 years max for the union of bioprinting and synthetic cells and 5- 10 for the first prototype of a super organ to be attempted.

If you would like to buy, please check my thread on /gamesale.
  Photos upon request.
 

Storage Solutions	Condition
Thin Jewel Case for CD/DVD/Blu-Ray	New. Clear front, black back
Standard Jewel Case for CD/DVD/Blu-Ray	New. Clear front and back
Genesis/Famicom Retro Protection	New, PET acid-free plastic cartridge protector
Super Famicom Cartridge Retro Protection	New, PET acid-free plastic cartridge protector
SNES Cartridge Retro Protection	New, PET acid-free plastic cartridge protector
NES Cartridge Retro Protection	New, PET acid-free plastic cartridge protector

 

amiibo	Condition
Tears of the Kingdom Link	Loose
Ocarina of Time Link	Loose
Majora's Mask Link	Loose
Smash Bros. Link	Loose
Skyward Sword Link	Loose
Zelda & Loftwing	Loose
Wind Waker Link	Loose
Wind Waker Zelda	Loose
Twilight Princess Link	Loose
Wolf Link and Midna	Loose
Callie	Loose
Marie	Loose
Inkling Boy [Neon Green]	Loose
Inkling Girl [Neon Pink]	Loose
Inkling Squid [Neon Purple]	Loose
Splatoon 2 Pearl	Loose
Splatoon 2 Marina	Loose
Splatoon 3 Inkling [Yellow]	Loose
Splatoon 3 Octoling [Blue]	Loose
Splatoon 3 Small Fry	Loose
Zelda Loftwing	New In Box
Sanrio amiibo cards	Sealed Pack
Mario Cereal Box	Cereal Removed/Flattened
Isabelle Summer Outfit	Open Box
Cyrus/K.K./Reese	New In Box/Damaged box
Tom Nook	New In Box
Mabel	New In Box

 

Digital Codes	Condition
SCOTT PILGRIM VS THE WORLD-STANDARD EDITION-US	Switch Digital Code

 

Figures	Condition
Chrono Trigger Chrono (Crono)/Robo/Eira (Ayla) Formation Arts Figure	Loose figure, most limbs are detachable by design, no missing parts
Pit Figma Figure	First Edition, Open Box, Contains everything but AR cards
Lillie (Pokemon) Nendoroid	Sealed. US edition from the Pokemon Center
Pixel Pal Mega Man	Sealed, damaged box
Pixel Pal SMB3 Mario	Sealed
Pixel Pal SMB3 Luigi	Sealed
Tracer Nendoroid (730)	Sealed
Tracer (Blizzard Entertainment Cute But Deadly Series 2 Vinyl)	Loose figure

 

Switch	Condition
Adventure Acedamia	Sealed
Atelier Ryza 3	Complete in Box
Azure Striker Gunvolt Striker Pack	Sealed
Bendy and the Ink Machine	Complete in Box
Cruel King and the Great Hero Storybook Edition	Complete in Box
Ender Lilies	Sealed, Japan Import
Grim Fandango Remastered	Complete in Box, no slip cover
Labyrinth of Refrain	Loose
Legend of Zelda Tears of the Kingdom	Sealed
Metroid Dread Collector's Edition	Sealed, a few dings associated with shipping
Monster Hunter Stories 2 Collector's Edition	Sealed
The Mummy Demastered	Complete in Box
River City Girls	Complete in Box, US Copy, Best Buy Variant
Shadowverse Champion's Battle	Loose
Shantae	Sealed
Shantae Risky's Revenge	Sealed
Shantae Collector's Edition	Sealed
Shantae Risky's Revenge Collector's Edition	Sealed
Teenage Mutant Ninja Turtles Cowabunga Collection	Sealed
Wonder Boy: The Dragon's Trap	Complete in Box
Yu-Gi-Oh Legacy of the Duelist: Link Evolution	Loose

 

Wii	Condition
Batallion Wars 2	Game and Case
Castle of Shikigami III	Complete in Box
Okami	Game and Case

 

WiiU Games	Condition
Batman Arkham City Armored Edition	Sealed
Disney Infinity 2.0	Sealed
Nintendoland	Complete in Box
Star Fox Guard	Complete in Box
Turbo Super Stunt Squad	Complete in Box, Art/Manual damage

 

DS	Condition
Animal Crossing Wild World	Game, Case, and inserts. No Manual
Final Fantasy Fables Chocobo's Dungeon DS+	Complete in Box, Japanese Import
Izuna 2 The Unemployed Ninja Returns	Loose
Super Scribblenauts	Loose

 

3DS	Condition
Kid Icarus Uprising (Japanese)	Game, Manual, and Case (No Big Box)
Kid Icarus Uprising	Complete in Box, Includes Big Box, Stand and AR cards
Senran Kagura Deep Crimson Double D Edition	Sealed

 

GBA	Condition
Car Battler Joe	Loose. Label imperfections
Chocobo Land A Game of Dice	Loose
Lady Sia	Loose, EU import
Lady Sia	Loose. Label imperfections
Super Mario Advance	No label

 

GB	Condition
Alleyway	Loose
Kid Dracula	Loose

 

NES	Condition
Adventure Island II	Loose
Faria	Game and Box. Box has some wear
Kid Icarus	Game, Box, and Manual; Box shows wear; Protective case for box and manual included
Rainbow Islands	Loose
Super Mario Bros & Duck Hunt	Loose

 

SNES	Condition
Metal Marines	Loose
Secret of Mana	Loose
Super Punch-Out	Loose
Super Scope 6	Loose
Wild Guns	Loose, Bad Label Damage

 

Gamecube	Condition
Cubivore	Loose disc
Pikmin	Player's Choice, Complete In Box
Star Fox Assault	Loose disc
Resident Evil 0	Player's Choice, Case and Discs, no manual
Resident Evil	Player's Choice, Complete In Box
Resident Evil	Complete In Box
Resident Evil 4	Complete In Box, Disc 2 has label wrinkles
Super Mario Sunshine	Game and case, no manual

 

Sega Genesis	Condition
Jurrassic Park	Loose cartridge, Sharpie on Label
Phantasy Star IV	Loose cartridge, Label Damage
Quackshot	Complete In Box
Rocket Knight Adventures	Loose cartridge, Label Damage
Spider-Man	Loose cartridge, Label Damage

 

Sega Saturn	Condition
NiGHTS Into Dreams	Complete in Box, Not for Resale Edition
Night Warriors Darkstalkers' Revenge	Loose

 

Sega Dreamcast	Condition
Project Justice	Complete in Box, page 2 detached from manual.
Power Stone 2	Loose

 

PSP	Condition
Daxter	Loose, Greatest Hits, Not For Resale
Power Stone Collection	Loose
Silent Hill Origins	Game and Case

 

PS1	Condition
Castlevania Chronicles	Complete in Box
Chocobo Racing	Loose
Chocobo no Fushigi na Dungeon	Complete in Box, Japanese Import
Chocobo's Dungeon 2	Complete in Box, Manual is badly water damaged
Dark Stalkers	Loose slim case version
Dark Stalkers 3	Disc and Manual, no back art
Rival Schools	Complete in Box
Silent Hill	Loose disc, Greatest Hits
Valkyrie Profile	Discs and Case, no manual
World of Dragon Warrior Torneko The Last Hope	Loose
Xenogears	Complete in Box

 

PS2	Condition
Avatar The Last Airbender	Disc and Case
Baldur's Gate Dark Alliance	Complete in Box; Greatest Hits
Bully	Greatest Hits, game & artwork
Burnout 3 Takedown	Complete, Water Damage on back cover art
Burnout Dominator	Case and Disc, Disc has superficial scratches but still boots
Castlevania Curse of Darkness	Loose, Disc has light scratching
Crash Bandicoot The Wrath of Cortex	Greatest Hits, Used, Disc and Case
Dragon Ball Z Budokai	Complete in Box
Dragon Ball Z Budokai Tenkaichi	Complete in Box; Greatest Hits
Final Fantasy X	Greatest Hits, Used, Disc and Case
Final Fantasy X-2	Complete; Greatest Hits
Haunting Ground	Complete in Box, Water Damage on art and manual
Killzone	Complete in Box
Grand Theft Auto Vice City	Disc, Case, Poster, No Manual
.Hack Infection	Complete in Box, Includes Anime DVD
.Hack Mutation	Complete in Box, Includes Anime DVD
.Hack Outbreak	Complete in Box, Includes Anime DVD
.Hack Quaratine	Discs and Case, no manual
Marvel vs Capcom 2	Cracked Disc, won't boot for me. Comes with case, no manual
Metal Gear Solid 2 Sons of Liberty	Greatest Hits, Used, Disc and Case
Naruto Ultimate Ninja 2	Disc and Case
Need for Speed Underground	Greatest Hits, Used, Disc and Case
Need for Speed Underground 2	Complete in Box
Need for Speed Hot Pursuit 2	Greatest Hits, Used, Disc and Case
Resident Evil Dead Aim	Game and Case, No manual
Scarface	Complete; Greatest Hits
Simpsons Road Rage	Loose, Greatest Hits
Valkyrie Profile 2	Complete In Box, some wear on the artwork and manual
Tekken Tag Tournament	Disc and Case, Greatest Hits, Full side Movie Gallery sticker on DVD face

 

PS3	Condition
Sports Champions	Complete in Box

 

PS4	Condition
APEX Construct	Sealed
Gravity Rush Remastered	Loose
J-Stars Victory VS+	Loose
SteamWorld Dig 2	Sealed

 

PS5	Condition
Battlefield 2042	Complete in Box
Final Fantasy VII Rebirth Deluxe Eiditon	Sealed

 

XBOX One	Condition
Watchdogs	Sealed

 

Consoles	Condition
Monster Hunter Rise Edition Switch	New in Box (No game code)
Oculus Quest 1	Complete in Box
Playstation 2 w/FreeMcBoot	Original PS2 "Fat" system. Won't read PS1 or blue PS2 discs. Laser could be ready to go bad, or just need re-alignment. Comes with a Yellow PS2 Memory Card that has FreeMcBoot on it. Free McBoot will allow you to to play games off of a hard drive if desired. No cords/controllers included.
Pokemon Scarlet/Violet Edition OLED Switch	New In Box
SNES Jr.	Includes Deck, RF Coax Cable, Third Party AC Adapter, and Third Party Controller. Small crack on the corner.
Splatoon 3 Edition OLED Switch	New In Box

 

Controllers	Condition
FortniteWildcat Joy-Con Set	Comes from the Fortnite Edition Console, never used
Joy-Con Grip	Bagged/Unused - Came with console
Oculus Quest 1/Rift S Left Controller	Used but very good condition. Comes with silicon case
Oculus Quest 1/Rift S Right Controller	Used but very good condition. Comes with silicon case
Platinum Gamecube Controller	Third Party, no nintendo logo, wired, good condition
Joy-Con (Left/Gray)	Good, no drift
Joy-Con (Right/Neon Red)	Good, no drift, Factory refurbished
SNES Controller	Third Party, no nintendo logo
SPIN Z WiiU Pro Controller	Black, Near Mint

 

Misc.	Condition
Chocobo White Mage Plush	Good
Chocobo Mystery Dungeon Everybuddy Pin	Thief costume
Chocobo's Dungeon Card Game Monsters Expansion Pack	Sealed
Black MagicGate 8MB PS2 Memory Card	Has Free McBoot loaded onto the card
Yellow Nyko MagicGate 8MB PS2 Memory Card	Has Free McBoot loaded onto the card
The Art of Splatoon 2	Sealed
Mario Kart 8 Target Pre-Order Keychain	Sealed. Cut in the film.
Nintendo Switch AC Adapter	Gently used
Nintendo 64 Memory Jumper Pack	OEM/Authentic Regular Pack, not to be confused with the expansion
Super Smash Bros. Ultimate Pre-Order Coin	Sealed
Breath of the Wild Sheikah Coin	From BotW Special Edition, Good condition
Pokken Art Cel Pre-Order Bonus	Sealed
Blastoise New 3DS Plates	Plates are mint and unused
Nintendo 3DS Stand	OEM, Came with Kid Icarus Uprising
Kid Icarus Uprising Players Guide (Imported from Japan, no AR cards)	Shows a little wear
Kid Icarus AR Card Set (205/404)	Contains 249/402 different North American (AKDE) cards, no duplicates. An itemized list can be provided upon request.
Kid Icarus AR - Pit Rally Cry Sealed Pack	Sealed pack of cards that contains AKDE-403,014,086
Shantae Risky's Revenge 2 LP Soundtrack Vinyl	Sealed
Super Mario Wonder Framed Art Print	Comes from Best Buy, Sealed
Tears of the Kingdom Pin Set (The Legend of Zelda)	From the TotK Collector's Edition. Mint
Tears of the Kingdom Art Book (The Legend of Zelda)	From the TotK Collector's Edition. Mint
Tears of the Kingdom Poster (The Legend of Zelda)	From the TotK Collector's Edition. Mint
Portal 2 Wheatley LED Flashlight	Sealed

 

Cases/Boxes/Inserts	Condition
Chrono Trigger Manual	SNES, Slight Wear
Chrono Trigger Orange Border Map	Slight Water Damage, 2 Pin holes in the folds, frame optional
Chrono Trigger Green Border Map	Slight Water Damage
Disgaea 1 Rosen Queen Edition	Everything but the game
Dragon Ball Z Budokai Tenkaichi	Greatest Hits Artwork
Shantae Slip Cover	Limited Run Nintendo Switch 5 Game Slip cover with protector
Burnout Revenge	PS2 case and manual
Doom Eternal Steelbook	PS4 Sealed, no game
Dot Hack (.HACK) Infection	PS2 case and manual
Dot Hack (.HACK) Mutation	Empty Case only
Dot Hack (.HACK) Outbreak	PS2 case and manual
Dragonball Z Budokai Tenkaichi	PS2 Greatest Hits Case Only, damaged clips but artwork is in good shape
The Legend of Zelda Tears of the Kingdom Collector's Edition	Includes everything but the game
Metroid Dread Special Edition	Box only, damaged from shipping
God of War Chains of Olympus	Case and Manual Only
Gran Turismo 3 A-spec	PS2 case only, 'Not For Sale' version
Super Smash Bros Ultimate Nintendo Switch ConsoleBox Only	Empty Box, good condition
Animal Crossing Nintendo Switch Console Box Only	Empty Box, good condition
Pokemon Dialga & Palkia Switch Lite Box Only	Empty Box, good condition
Rival Schools Front Artwork	Just the front artwork
Fortnite Nintendo Switch Console Box Only	Empty Box, good condition
The Witcher III Wild Hunt	Empty Case, good condition
Tears of the Kingdom Steelbook (The Legend of Zelda)	From the TotK Collector's Edition. Empty Case, Mint
Witch's Wish Box	Empty Box, good condition

 

Freebies	Condition
Playstation 2 IDE Connector	Upgraded my HD Adapter to SATA, these are the old/leftover connectors.
Nintendo Switch Cart Caddy	3D Printed. Holds 16 carts. Can connect to an OEM dock.
Yoshi Mario Kart Keychain	Good
Small Jotaro Kujo Figure	3D Printed. From Jojo's Bizarre Adventure All-Star Battle-R
Large Jotaro Kujo Figure	3D Printed. From Jojo's Bizarre Adventure All-Star Battle-R
2 Cartridge DS Travel Case	2 Cartridge DS Travel Case
4 Cartridge DS Travel Case	4 Cartridge DS Travel Case
Wonderswan Display Stand	3D Printed. Does not fit Wonderswan Crystal
Lavos Figure	3D printed in PLA Wood Filament. Not my model, found on thingiverse.

 

Wants	Console
Kid Icarus Uprising AR Cards: AKDE-025 AKDE-039 (Will consider others)	None
Asheron's Call Memorabilia	PC
Game & Watch Devices (Excluding 35th Mario & Zelda editions)	G&W
Trip World	GB
Classic NES Series: Excitebike	GBA
Classic NES Series: Dr. Mario	GBA
Classic NES Series: Pac-Man	GBA
Kirby Tilt 'n' Tumble	GBA
Pokemon Puzzle Challenge	GBC
R.O.B. Accessories	NES
Yo Noid	NES
Pirates Of Dark Water	SNES
Chrono Trigger Box/Inserts	SNES
Marvel Super Heroes War of the Gems	SNES
Ribbit King	NGC
Mario Wonder Cards/Pins Pre-Order Bonuses	None
Metal Gear Acid	PSP
Racing Lagoon	PS1
Parasite Eve 2	PS1
Red Ninja (Art/Manual)	PS2
Night Warriors Darkstalkers Revenge (Case & Manual Only)	Saturn
Wonderswan Games	Wonderswan
DS Download Station 1-8,10,11,12,14,16,17,20	DS
Oni	PS2
Sega Master System Games	Master System
ROG Ally Extreme	PC

Prices are subjective, negotiable, and do not include shipping.   If you would like to trade, check out my thread on /gameswap.   Also accepting Cashapp and Venmo.   One Freebie per order.   Photos upon request.
 

Storage Solutions	Price	Condition
Thin Jewel Case for CD/DVD/Blu-Ray	1/per	New. Clear front, black back
Standard Jewel Case for CD/DVD/Blu-Ray	1/per	New. Clear front and back
Genesis/Famicom Retro Protection	1/per	New, PET acid-free plastic cartridge protector
Super Famicom Cartridge Retro Protection	1/per	New, PET acid-free plastic cartridge protector
SNES Cartridge Retro Protection	1/per	New, PET acid-free plastic cartridge protector
NES Cartridge Retro Protection	1/per	New, PET acid-free plastic cartridge protector

 

amiibo	Price	Condition
Tears of the Kingdom Link	25	Loose
Ocarina of Time Link	25	Loose
Majora's Mask Link	30	Loose
Smash Bros. Link	20	Loose
Skyward Sword Link	20	Loose
Zelda & Loftwing	15	Loose
Wind Waker Link	20	Loose
Wind Waker Zelda	20	Loose
Twilight Princess Link	50	Loose
Wolf Link and Midna	25	Loose
Callie	20	Loose
Marie	20	Loose
Inkling Boy [Neon Green]	15	Loose
Inkling Girl [Neon Pink]	25	Loose
Inkling Squid [Neon Purple]	17	Loose
Splatoon 2 Pearl	20	Loose
Splatoon 2 Marina	20	Loose
Splatoon 3 Inkling [Yellow]	22	Loose
Splatoon 3 Octoling [Blue]	20	Loose
Splatoon 3 Small Fry	20	Loose
Zelda Loftwing	30	New In Box
Sanrio amiibo cards	12	Sealed Pack
Mario Cereal Box	15	Cereal Removed/Flattened
Isabelle Summer Outfit	40	Open Box
Cyrus/K.K./Reese	18	New In Box/Damaged box
Tom Nook	12	New In Box
Mabel	9	New In Box

 

Digital Codes	Price	Condition
SCOTT PILGRIM VS THE WORLD-STANDARD EDITION-US	10	Switch Digital Code

 

Figures	Price	Condition
Chrono Trigger Chrono (Crono)/Robo/Eira (Ayla) Formation Arts Figure	100	Loose figure, most limbs are detachable by design, no missing parts
Pit Figma Figure	90	First Edition, Open Box, Contains everything but AR cards
Lillie (Pokemon) Nendoroid	300	Sealed. US edition from the Pokemon Center
Pixel Pal Mega Man	30	Sealed, damaged box
Pixel Pal SMB3 Mario	30	Sealed
Pixel Pal SMB3 Luigi	30	Sealed
Tracer Nendoroid (730)	30	Sealed
Tracer (Blizzard Entertainment Cute But Deadly Series 2 Vinyl)	8	Loose figure

 

Switch	Price	Condition
Adventure Acedamia	30	Sealed
Atelier Ryza 3	90	Complete in Box
Azure Striker Gunvolt Striker Pack	40	Sealed
Bendy and the Ink Machine	30	Complete in Box
Cruel King and the Great Hero Storybook Edition	60	Complete in Box
Ender Lilies	55	Sealed, Japan Import
Grim Fandango Remastered	45	Complete in Box, no slip cover
Labyrinth of Refrain	65	Loose
Legend of Zelda Tears of the Kingdom	60	Sealed
Metroid Dread Collector's Edition	110	Sealed, a few dings associated with shipping
Monster Hunter Stories 2 Collector's Edition	160	Sealed
The Mummy Demastered	55	Complete in Box
River City Girls	120	Complete in Box, US Copy, Best Buy Variant
Shadowverse Champion's Battle	15	Loose
Shantae	50	Sealed
Shantae Risky's Revenge	50	Sealed
Shantae Collector's Edition	150	Sealed
Shantae Risky's Revenge Collector's Edition	150	Sealed
Teenage Mutant Ninja Turtles Cowabunga Collection	30	Sealed
Wonder Boy: The Dragon's Trap	40	Complete in Box
Yu-Gi-Oh Legacy of the Duelist: Link Evolution	18	Loose

 

Wii	Price	Condition
Batallion Wars 2	11	Game and Case
Castle of Shikigami III	75	Complete in Box
Okami	10	Game and Case

 

WiiU Games	Price	Condition
Batman Arkham City Armored Edition	40	Sealed
Disney Infinity 2.0	15	Sealed
Nintendoland	10	Complete in Box
Star Fox Guard	10	Complete in Box
Turbo Super Stunt Squad	200	Complete in Box, Art/Manual damage

 

DS	Price	Condition
Animal Crossing Wild World	35	Game, Case, and inserts. No Manual
Final Fantasy Fables Chocobo's Dungeon DS+	25	Complete in Box, Japanese Import
Izuna 2 The Unemployed Ninja Returns	70	Loose
Super Scribblenauts	5	Loose

 

3DS	Price	Condition
Kid Icarus Uprising (Japanese)	40	Game, Manual, and Case (No Big Box)
Kid Icarus Uprising	120	Complete in Box, Includes Big Box, Stand and AR cards
Senran Kagura Deep Crimson Double D Edition	75	Sealed

 

GBA	Price	Condition
Car Battler Joe	180	Loose. Label imperfections
Chocobo Land A Game of Dice	15	Loose
Lady Sia	30	Loose, EU import
Lady Sia	50	Loose. Label imperfections
Super Mario Advance	13	No label

 

GB	Price	Condition
Alleyway	5	Loose
Kid Dracula	240	Loose

 

NES	Price	Condition
Adventure Island II	25	Loose
Faria	200	Game and Box. Box has some wear
Kid Icarus	180	Game, Box, and Manual; Box shows wear; Protective case for box and manual included
Rainbow Islands	35	Loose
Super Mario Bros & Duck Hunt	10	Loose

 

SNES	Price	Condition
Metal Marines	90	Loose
Secret of Mana	55	Loose
Super Punch-Out	25	Loose
Super Scope 6	22	Loose
Wild Guns	270	Loose, Bad Label Damage

 

Gamecube	Price	Condition
Cubivore	350	Loose disc
Pikmin	50	Player's Choice, Complete In Box
Star Fox Assault	30	Loose disc
Resident Evil 0	15	Player's Choice, Case and Discs, no manual
Resident Evil	25	Player's Choice, Complete In Box
Resident Evil	27	Complete In Box
Resident Evil 4	30	Complete In Box, Disc 2 has label wrinkles
Super Mario Sunshine	40	Game and case, no manual

 

Sega Genesis	Price	Condition
Jurrassic Park	10	Loose cartridge, Sharpie on Label
Phantasy Star IV	70	Loose cartridge, Label Damage
Quackshot	40	Complete In Box
Rocket Knight Adventures	37	Loose cartridge, Label Damage
Spider-Man	12	Loose cartridge, Label Damage

 

Sega Saturn	Price	Condition
NiGHTS Into Dreams	40	Complete in Box, Not for Resale Edition
Night Warriors Darkstalkers' Revenge	50	Loose

 

Sega Dreamcast	Price	Condition
Project Justice	225	Complete in Box, page 2 detached from manual.
Power Stone 2	90	Loose

 

PSP	Price	Condition
Daxter	10	Loose, Greatest Hits, Not For Resale
Power Stone Collection	30	Loose
Silent Hill Origins	50	Game and Case

 

PS1	Price	Condition
Castlevania Chronicles	165	Complete in Box
Chocobo Racing	55	Loose
Chocobo no Fushigi na Dungeon	20	Complete in Box, Japanese Import
Chocobo's Dungeon 2	70	Complete in Box, Manual is badly water damaged
Dark Stalkers	70	Loose slim case version
Dark Stalkers 3	50	Disc and Manual, no back art
Rival Schools	130	Complete in Box
Silent Hill	105	Loose disc, Greatest Hits
Valkyrie Profile	325	Discs and Case, no manual
World of Dragon Warrior Torneko The Last Hope	90	Loose
Xenogears	150	Complete in Box

 

PS2	Price	Condition
Avatar The Last Airbender	10	Disc and Case
Baldur's Gate Dark Alliance	17	Complete in Box; Greatest Hits
Bully	15	Greatest Hits, game & artwork
Burnout 3 Takedown	11	Complete, Water Damage on back cover art
Burnout Dominator	9	Case and Disc, Disc has superficial scratches but still boots
Castlevania Curse of Darkness	60	Loose, Disc has light scratching
Crash Bandicoot The Wrath of Cortex	10	Greatest Hits, Used, Disc and Case
Dragon Ball Z Budokai	11	Complete in Box
Dragon Ball Z Budokai Tenkaichi	15	Complete in Box; Greatest Hits
Final Fantasy X	6	Greatest Hits, Used, Disc and Case
Final Fantasy X-2	6	Complete; Greatest Hits
Haunting Ground	300	Complete in Box, Water Damage on art and manual
Killzone	15	Complete in Box
Grand Theft Auto Vice City	10	Disc, Case, Poster, No Manual
.Hack Infection	20	Complete in Box, Includes Anime DVD
.Hack Mutation	45	Complete in Box, Includes Anime DVD
.Hack Outbreak	65	Complete in Box, Includes Anime DVD
.Hack Quaratine	300	Discs and Case, no manual
Marvel vs Capcom 2	60	Cracked Disc, won't boot for me. Comes with case, no manual
Metal Gear Solid 2 Sons of Liberty	10	Greatest Hits, Used, Disc and Case
Naruto Ultimate Ninja 2	10	Disc and Case
Need for Speed Underground	10	Greatest Hits, Used, Disc and Case
Need for Speed Underground 2	24	Complete in Box
Need for Speed Hot Pursuit 2	10	Greatest Hits, Used, Disc and Case
Resident Evil Dead Aim	50	Game and Case, No manual
Scarface	40	Complete; Greatest Hits
Simpsons Road Rage	15	Loose, Greatest Hits
Valkyrie Profile 2	40	Complete In Box, some wear on the artwork and manual
Tekken Tag Tournament	10	Disc and Case, Greatest Hits, Full side Movie Gallery sticker on DVD face

 

PS3	Price	Condition
Sports Champions	10	Complete in Box

 

PS4	Price	Condition
APEX Construct	15	Sealed
Gravity Rush Remastered	60	Loose
J-Stars Victory VS+	30	Loose
SteamWorld Dig 2	20	Sealed

 

PS5	Price	Condition
Battlefield 2042	20	Complete in Box
Final Fantasy VII Rebirth Deluxe Eiditon	150	Sealed

 

XBOX One	Price	Condition
Watchdogs	15	Sealed

 

Consoles	Price	Condition
Monster Hunter Rise Edition Switch	420	New in Box (No game code)
Oculus Quest 1	180	Complete in Box
Playstation 2 w/FreeMcBoot	80	Original PS2 "Fat" system. Won't read PS1 or blue PS2 discs. Laser could be ready to go bad, or just need re-alignment. Comes with a Yellow PS2 Memory Card that has FreeMcBoot on it. Free McBoot will allow you to to play games off of a hard drive if desired. No cords/controllers included.
Pokemon Scarlet/Violet Edition OLED Switch	400	New In Box
SNES Jr.	120	Includes Deck, RF Coax Cable, Third Party AC Adapter, and Third Party Controller. Small crack on the corner.
Splatoon 3 Edition OLED Switch	400	New In Box

 

Controllers	Price	Condition
FortniteWildcat Joy-Con Set	120	Comes from the Fortnite Edition Console, never used
Joy-Con Grip	8	Bagged/Unused - Came with console
Oculus Quest 1/Rift S Left Controller	115	Used but very good condition. Comes with silicon case
Oculus Quest 1/Rift S Right Controller	115	Used but very good condition. Comes with silicon case
Platinum Gamecube Controller	20	Third Party, no nintendo logo, wired, good condition
Joy-Con (Left/Gray)	35	Good, no drift
Joy-Con (Right/Neon Red)	35	Good, no drift, Factory refurbished
SNES Controller	10	Third Party, no nintendo logo
SPIN Z WiiU Pro Controller	25	Black, Near Mint

 

Misc.	Price	Condition
Chocobo White Mage Plush	20	Good
Chocobo Mystery Dungeon Everybuddy Pin	5	Thief costume
Chocobo's Dungeon Card Game Monsters Expansion Pack	25	Sealed
Black MagicGate 8MB PS2 Memory Card	20	Has Free McBoot loaded onto the card
Yellow Nyko MagicGate 8MB PS2 Memory Card	20	Has Free McBoot loaded onto the card
The Art of Splatoon 2	300	Sealed
Mario Kart 8 Target Pre-Order Keychain	10	Sealed. Cut in the film.
Nintendo Switch AC Adapter	20	Gently used
Nintendo 64 Memory Jumper Pack	20	OEM/Authentic Regular Pack, not to be confused with the expansion
Super Smash Bros. Ultimate Pre-Order Coin	15	Sealed
Breath of the Wild Sheikah Coin	25	From BotW Special Edition, Good condition
Pokken Art Cel Pre-Order Bonus	7	Sealed
Blastoise New 3DS Plates	200	Plates are mint and unused
Nintendo 3DS Stand	30	OEM, Came with Kid Icarus Uprising
Kid Icarus Uprising Players Guide (Imported from Japan, no AR cards)	30	Shows a little wear
Kid Icarus AR Card Set (205/404)	600	Contains 249/402 different North American (AKDE) cards, no duplicates. An itemized list can be provided upon request.
Kid Icarus AR - Pit Rally Cry Sealed Pack	20	Sealed pack of cards that contains AKDE-403,014,086
Shantae Risky's Revenge 2 LP Soundtrack Vinyl	55	Sealed
Super Mario Wonder Framed Art Print	25	Comes from Best Buy, Sealed
Tears of the Kingdom Pin Set (The Legend of Zelda)	20	From the TotK Collector's Edition. Mint
Tears of the Kingdom Art Book (The Legend of Zelda)	65	From the TotK Collector's Edition. Mint
Tears of the Kingdom Poster (The Legend of Zelda)	20	From the TotK Collector's Edition. Mint
Portal 2 Wheatley LED Flashlight	120	Sealed

 

Cases/Boxes/Inserts	Price	Condition
Chrono Trigger Manual	100	SNES, Slight Wear
Chrono Trigger Orange Border Map	80	Slight Water Damage, 2 Pin holes in the folds, frame optional
Chrono Trigger Green Border Map	80	Slight Water Damage
Disgaea 1 Rosen Queen Edition	150	Everything but the game
Dragon Ball Z Budokai Tenkaichi	5	Greatest Hits Artwork
Shantae Slip Cover	100	Limited Run Nintendo Switch 5 Game Slip cover with protector
Burnout Revenge	5	PS2 case and manual
Doom Eternal Steelbook	15	PS4 Sealed, no game
Dot Hack (.HACK) Infection	20	PS2 case and manual
Dot Hack (.HACK) Mutation	20	Empty Case only
Dot Hack (.HACK) Outbreak	30	PS2 case and manual
Dragonball Z Budokai Tenkaichi	10	PS2 Greatest Hits Case Only, damaged clips but artwork is in good shape
The Legend of Zelda Tears of the Kingdom Collector's Edition	100	Includes everything but the game
Metroid Dread Special Edition	5	Box only, damaged from shipping
God of War Chains of Olympus	15	Case and Manual Only
Gran Turismo 3 A-spec	5	PS2 case only, 'Not For Sale' version
Super Smash Bros Ultimate Nintendo Switch ConsoleBox Only	90	Empty Box, good condition
Animal Crossing Nintendo Switch Console Box Only	20	Empty Box, good condition
Pokemon Dialga & Palkia Switch Lite Box Only	30	Empty Box, good condition
Rival Schools Front Artwork	25	Just the front artwork
Fortnite Nintendo Switch Console Box Only	20	Empty Box, good condition
The Witcher III Wild Hunt	20	Empty Case, good condition
Tears of the Kingdom Steelbook (The Legend of Zelda)	30	From the TotK Collector's Edition. Empty Case, Mint
Witch's Wish Box	50	Empty Box, good condition

 

Freebies	Price	Condition
Playstation 2 IDE Connector	Free with purchase	Upgraded my HD Adapter to SATA, these are the old/leftover connectors.
Nintendo Switch Cart Caddy	Free with purchase	3D Printed. Holds 16 carts. Can connect to an OEM dock.
Yoshi Mario Kart Keychain	Free with purchase	Good
Small Jotaro Kujo Figure	Free with purchase	3D Printed. From Jojo's Bizarre Adventure All-Star Battle-R
Large Jotaro Kujo Figure	Free with purchase	3D Printed. From Jojo's Bizarre Adventure All-Star Battle-R
2 Cartridge DS Travel Case	Free with purchase	2 Cartridge DS Travel Case
4 Cartridge DS Travel Case	Free with purchase	4 Cartridge DS Travel Case
Wonderswan Display Stand	Free with purchase	3D Printed. Does not fit Wonderswan Crystal
Lavos Figure	Free with purchase	3D printed in PLA Wood Filament. Not my model, found on thingiverse.

 

There are two types of pigment that give hair its color: eumelanin and pheomelanin. Pheomelanin colors the hair red or orange; eumelanin determines the darkness and shade of the color. What this means is that majority of hair will have some level of warmth, orangeness etc, especially in sunlight. The warm toned sun brightens the orange pigments in the hair. This does not mean you are ginger
Not all ginger people are pale or caucasian. While the population of redheads is heavily made up of white people, there are still individuals who belong to the BAME community. In addition to this, not all redheads are unable to tan.
Genetics work in wonderful ways. The number of possible combinations of DNA sequences is astronomical due to the vast number of nucleotides (A, T, C, and G) that make up the DNA and the length of DNA sequences. It is stupid to believe only certain traits can belong to an individual.
There is no one specific "redhead gene". Redhair is a result of one or more genetic variations on the MC1R gene. You can have both alleles of more than one variant but still not display red hair, due to your eumelanin. Hair colour is a polygenic trait, meaning it is influenced by multiple genes. Even if someone carries two copies of the mutated MC1R gene, other genes involved in melanin production and distribution can influence the final hair colour, resulting in a non-red hair phenotype.
People can be phenotypically brunette/blonde whilst being genotypically red/ginger. You cannot be phenotypically red/ginger without being genotypically red/ginger as red/ginger hair. To display red or ginger hair, an individual must have the genetic variants associated with red hair (mutations in the MC1R gene). This is because red hair is a result of specific genetic changes that increase pheomelanin production. Without these genetic changes, it is not possible to have the red hair phenotype.
Before anyone jumps on here and says "well I did the Ancestry/23&Me/etc DNA test and it says I dont have red hair". Ancestry and 23&Me only test for 3 markers linked to red hair, these are R151C, R160W and D294H. There are 10-12 well researched MC1R variants that are associated with redhair. So taking the DNA test isnt 100% fool proof, but for a vast majority of individuals who are unsure or want to find out further information, the test can be useful.
Please can we stop entertaining the random obvious blondes and brunettes who use this subreddit to karma farm or compliment fish?

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storm, story, straight, strange, stranger, strategic, strategy, stream, street, strength, strengthen, stress, stretch, strike, string, strip, stroke, strong, strongly, structural, structure, struggle, student, studio, study, stuff, stupid, style, subject, submit, subsequent, substance, substantial, substitute, succeed, success, successful, successfully, such, sudden, suddenly, sue, suffer, sufficient, sugar, suggest, suggestion, suicide, suit, summer, summit, sun, super, supply, support, supporter, suppose, supposed, Supreme, sure, surely, surface, surgery, surprise, surprised, surprising, surprisingly, surround, survey, survival, survive, survivor, suspect, sustain, swear, sweep, sweet, swim, swing, switch, symbol, symptom, system, table, tactic, tail, take, tale, talent, talk, tall, tank, tap, tape, target, task, taste, tax, taxi, tea, teach, teacher, teaching, team, tear, technical, technique, technology, teen, teenager, telephone, telescope, television, tell, temperature, 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weather, web, website, wedding, week, weekend, weekly, weigh, weight, welcome, welfare, well, west, western, wet, what, whatever, wheel, when, whenever, where, whereas, whether, which, while, whisper, white, who, whole, whom, whose, why, wide, widely, widespread, wife, wild, wildlife, will, willing, win, wind, window, wine, wing, winner, winter, wipe, wire, wisdom, wise, wish, with, withdraw, within, without, witness, woman, wonder, wonderful, wood, wooden, word, work, worker, working, workout, workplace, works, workshop, world, worried, worry, worth, would, wound, wrap, write, writer, writing, wrong, yard, yeah, year, yell, yellow, yes, yesterday, yet, yield, you, young, your, yours, yourself, youth, zone.

I read:

Two eggs fertilized by two sperm coincided in a uterus and, instead of giving rise to two sisters, they fused to form a single person: Karen Keegan. When she was 52 years old, this woman from Boston suffered very serious kidney failure, but luckily she had three children willing to donate a kidney to her. The doctors did genetic tests to see which offspring was most compatible and they got a major surprise: the test said that two of them were not her children. The reality was even more astonishing: Karen Keegan had two different DNA sequences, two genomes, depending on the cell you looked at.

This makes me wonder: how often do humans have two different genomes? (Truly different like in the previous example, not just a few mutations)

(I am not a creationist, but I am a bored contrarian and I need to argue with somebody right now. Also, I'm trying to get a better grasp of the rules of phylogeny, so maybe y'all can teach me something.).
Reasons that I think the LUCA was an animal:
1: Unicellularity is hard. We have this idealized conception of a unicellular microbe, where you stick a single cell on a petri dish and then overnight it becomes a million cells, but the vast majority of life can't do anything like this--certainly the LUCA couldn't, right? I think there would be an advantage to early life being multicellular, in that early life could "borrow" RNA/DNA/proteins with neighboring cells. Also they wouldn't need a full complement of molecular machinery if their neighbor can help out, even if their neighbor is a different species. Just like I can borrow my neighbor's stove if I'm making a special meal, early life probably borrowed very basic molecular machinery from the neighboring cell. And if any of their genes broke, they could maybe get a replacement from their neighbor? I think that it's hard to live all by your lonesome self if you're a primitive life form, so being multicellular is easier since you can rely on neighbor cells for various things and don't have to do everything yourself. I also think there's a very blurry line between a single multicellular organism and an interdependent community of unicellular organisms where none of the organisms could survive without the others. Many scientists agree that early life was like this—an interdependent community—and much life still is like this. But why should this type of community be considered to be closer to unicellularity than multicellularity?
2: The nucleus seems like a leftover relic from the RNA world. The primary function seems to be to separate transcription and translation, but why would you want to do this in a DNA organism? Why are you separating transcription from translation if you already have this elegant system in prokaryotes of just having the ribosome and the RNA polymerase right next to each other doing their things almost simultaneously, much, much faster and more efficiently than eukaryotes. Why make everything ten times slower by evolving a nucleus when you could just not evolve a nucleus? Evolution doesn’t plan ahead, and I fail to see how the nucleus is a favorable adaptation in the short term. On the other hand, a nucleus makes a ton of sense for an organism with an RNA genome because you'd need a way to separate your genomic RNA from your RNA transcripts so they could be regulated separately -- You wouldn't want to splice up or run a ribosome over your RNA genome, that would be a disaster.
3: Having a nucleus would make it easier to evolve DNA. Whatever enzyme is deoxygenating the RNA backbone wouldn't run into the problem of accidentally deoxygenating the RNA transcripts. Since the transcripts are outside the nucleus.
4: The nucleus could be an early form of cell specialization for a multicellular life form. If we think of the nucleus as a separate cell from the cytoplasmic space, I think the picture of early RNA life becomes clearer. Some cells/compartments evolve to specialize in replication and transcription -- these become the nucleus -- wheras other cells/compartments become specialized for translation of proteins --these became the cytoplasmic space, which ultimately engulfed the nucleus. In this primitive RNA organism, there would have been little distinction between replication and transcription. The cells of various sizes would have shared proteins, allowing the smaller cells specialized for replication/transcription to still benefit from the gene products being produced in the larger cells specialized for translation. The smaller cells would do a more faithful job of replicating the genome and not have to risk damaging their genes in the messy process of gene expression.
5: Based on the multiple chromosomes in the nucleus, the first Eukaryote was a likely a synthesis of multiple organisms. Multiple organisms implies multicellular. If we look inside the nucleus, we see multiple, weird, x-shaped chromosomes, with a bunch of dumb hacks (centrosomes, telomerase, etc) to keep them from falling apart as they replicate. The bacterial system makes so much more sense for modern organisms -- just having a single circular chromosome: simple, elegant, effective. Again, the eukaryotic system seems like a molecular fossil from an earlier era where these features were actually necessary. I'd argue that the eukaryotic system supports multiple chromosomes because the original chromosomes were the RNA genomes of different interdependent organisms that lived in a multicellular community. Their RNA migrated into a single nucleus for better regulated and better synchronized replication of the community genes.
6: The homologies between Porifera and Amoebozoa make no sense if Animals came from Choanoflagellates. It is widely assumed that multicellular eukaryotes evolved from single-celled eukaryotes, and this seems to be the case in land plants, at least, since they're so similar to algae which obviously came before land plants--but are we sure that it isn't the other way around for animals? Conventional wisdom is that animals evolved from choanoflagellates, and we see very similar cells to choanoflagellates in Porifera called choanocytes. BUT: Porifera (sponges) also have amoebocytes, which look and function a lot like amoebas. Amoebas are believed to be relatively closely related to animals, although not as closely related as choanoflagellates. Yet animals cannot have evolved from both amoebas and choanoflagellates, and choanoflagellates look nothing like amoebas. Isn't it an odd coincidence that amoebocyte cells in sponges are so much like amoebas? If animals came from choanoflagellates, then the similarity of amoebas and amoebocytes would have to be a coincidence. An alternative direction of evolution makes a lot more sense to me: Animals came first, and amoebas and choanoflagellates are separate lineages of reduced animals that have evolved down to only being a single cell. Other eukaryotes (such as fungi, algae and plants) could be evolved from these single-celled descendants of animals.
7: Gene homologies between microsporidia and prokaryotes. Since microsporidia are very obviously reduced fungi, this makes no sense in the current prokaryote-first paradigm, so these gene homologies are handwaved away as being the result of horizontal gene transfer. But what if it isn't horizontal gene transfer? Microsporidia is a parasitic clade of fungi which has lost most of its genes, seemingly lost its mitochondria (are we absolutely sure they ever had mitochondria?) and shrunk to about the size of a bacterium. Its shrunk so much and lost so many genes that it actually is able to withstand mutations to very basic molecular machinery such as its ribosomes, which are very different from the ribosomes of other eukaryotes and seem more similar to the smaller ribosomes of prokaryotes. Perhaps prokaryotes are just even-further-reduced microsporidia that have lost their nucleus, circularized their DNA (which can also happen in cancer cells, google "eccDNA") and further streamlined their molecular machinery.
8: We can learn a lot about the order of the clades from the type of ecological niches they currently occupy. For example: there do exist extremophile bacteria, so there's nothing inherent in bacterial microbiology that prevents them from evolving into extremophiles. So why do we see mostly extremophile archaea, but bacteria occupy almost all of the generalist, high productivity microbial niches? I'd argue: Probably, archaea had a head start in evolving specialized adaptations for extremophile environments. Probably, archaea came first. Imagine an archaeon existing before there were any bacteria, and it evolved to occupy all microbe ecological niches. Then bacteria came along in a new adaptive radiation with superior molecular biology. They were able to supplant archaea from most generalist niches but haven't been able to challenge archaea for extremophile niches for which archaea have specialized genes and specialized adaptations. And neither bacteria nor archaea seriously challenge eukaryotes for the larger ecological niches which require even more specialized adaptations. This to me implies that Eukaryotes came first, archaea came second, and bacteria are the most recent domain.
9: Animals almost exclusively occupy the large, complex, predator niche. I'd argue that the large predator niche, of all ecological niches, is the one where the greatest advantage is given to the organism who evolves to fill the niche first. Because selection pressure changes a lot once the predator appears: Things that can't run away from the predator are forced to make themselves as unappetizing as possible. So they can't have complex proteins, since complex proteins = tastier. So how can any clade evolve into a predator if there already exists a predator clade that could eat it? The fossil record seems to think: It can’t. Throughout the entire fossil record for which we have good records (since the Cambrian), the predator is always an animal. Never does a slime mold or a fungus something evolve muscles and teeth and start competing with animals for the predator niche. But this isn’t 100% true -- you have Venus fly traps, I suppose? So that’s one exception, the only one I can think of. Animal predators today have billions of years of evolutionary head start evolving such things as muscles, a nervous system, circulatory system, etc. If anything else other than an animal starts evolving complex structures or energy storage, it's only going to make itself tastier to an animal. The predator is also the niche that cares the least about the efficiency of basic molecular processes -- it doesn't need to be efficient when the world is its buffet. For this reason, I'd argue that the predator clade must have established itself very early. Probably the kingdom that occupies the apex predator niche at any given time is the absolute oldest lineage of multicellular life. Because long, long after all the original autotrophs have gone extinct, replaced with things that don't waste so much energy and have more efficient and streamlined molecular biology, the apex predator clade would remain on its throne, since nothing, I'd argue, would be able to compete with its evolutionary head start evolving so many complex adaptations for multicellularity. Are we to believe there was ever a time when the apex predator niche was something other than an animal? It's difficult to imagine. If that apex predator was a prokaryote, what is it about animal molecular biology that allowed it to overcome such extreme odds and supplant that prokaryote as the apex predator?
10: The fossil record of animals before the Cambrian is probably very incomplete. The first complex animals in the fossil record (the cambrian explosion) seem very, very advanced already -- I think this is a representation that our fossil record is incomplete and animals are a much older clade than they seem. Since predators are rarer in an ecosystem, and may have been even rarer when energy was scarcer due to less oxygen in the atmosphere (early heterotrophic life likely breathed sulfur compounds), we may simply not have any good fossils of animals from before the cambrian.
11: It's also possible that early animals simply weren't made out of the right material to fossilize. Maybe Archean-eon animals had no bones or anything like that and so they didn't fossilize, so we don't have examples of them. We can't assume that just because you don't find fossilized animals from ~3 billion years ago doesn't mean they weren't around then. And even if we did find fossilized animals from that long ago, they were probably so radically different from modern animals that we might misidentify them. For example, we have many fossils of strange creatures from billions of years ago, nobody knows what they are. Maybe they are animals? Example: Google “Grypania”. Currently there is a debate on whether these are algae or bacteria. But they are quite large, and they look sortof wormlike, so, in my view, there’s no reason they couldn’t be primitive animals.
12: Animals are slow reproducing but have the most sophisticated adaptations for multicellularity. The slower something reproduces, the slower it evolves, since there’s less opportunities for mutations. So how did animals have time to acquire so many complex adaptations for multicellularity? They must be an especially ancient lineage, something that has been multicellular much longer than anything else – otherwise they wouldn’t have had time to acquire so many complex adaptations for multicellularity.
13: Phylogenetic trees based on bioinformatics suffer from "long branch attraction" artefacts -- where fast reproducing, simple, and numerous organisms group together at the base of the tree. This is a well-known problem for making phylogenetic trees. Since prokaryotes are so much more numerous and reproduce so much faster than eukaryotes, it’s natural that they would have the most genetic diversity, even if they evolved later. The appearance of prokaryotes at the base of the tree of life derived from bioinformatics algorithms may be a product of long branch attraction.
14: Counterpoints on mitochondrias. I’ll admit that mitochondrias do look a lot like bacterial symbiotes, but that doesn't necessarily mean the original eukaryotes had mitochondrias. Once alphaproteobacteria evolved, it might have infected many lineages of eukaryotes simultaneously, since nothing had resistance to its infections yet. Maybe it impersonated the mitosome and supplanted its function, and did such a good job as a mitosome that the only surviving eukaryotic lineages are ones with alphaproteobacterial infections. Also, if we assume that bacteria are reduced eukaryotes, then many of the gene homologies for mitochondria associated genes could have been present in the eukaryotic LUCA, and perhaps they were used for regulating the mitosome which preceded mitochondrias. I think that the mitochondria is an interesting piece of the puzzle, but it doesn't conclusively demonstrate that prokaryotes came first.
….
I make ASCII phylogenetic tree for fun:

 _______________________________________________Placazoa 1____LUCA_____________________________________________5_____Ctenophora _______Cnidaria ___Bilateria ______________________________________________Porifera _____________Choanoflagellatea _________Dinoflagellata _______Algae ____Viridiplantae __2___________________________________Amoebozoa _________________________________Fungi _3_______Microsporidia __4____Archaea ^ ______Bacteria (endosymbiosis into various eukaryotic clades) _____Mitochondria ^ (horizontal gene transfer from now-extinct RNA life forms to bacteria and archaea) ______________________primitive RNA life forms (extinct) 1: A community of highly interdependent organisms evolves into multicellular eukaryotic progenator with a DNA genome inside a nucleus. This hypothetical LUCA is a relatively large and complex heterotroph which fed on primitive RNA life forms. 2: First truely unicellular (non-colonial) organisms (independent living isn't easy!) 3: Extreme miniaturization 4: Loss of eukaryotic nucleus 5: Complex adaptations for apex predator niches (neurons, etc) 

A little tricky to get going - Ghost deck and skip for free rare joker next shop is DNA then used Ankh to duplicate. First started copying lucky club Ace then eventually found a poli club ace in a pack and gave it red seal a while later.
FCM3Y2RW

Most of you are probably already aware of this theory. It has been around for years. The great twist of Yandere Simulator will be the reveal that Megami and Ayano are sisters.
This had been a widly accepted theory since the release of Megami's first design, back when she still had black hair. Her design at the time was extremely similar to Kill la Kill character, Satsuki Kiryun. For those who are unaware, Satsuki is the main antagonist of the anime, and the president of the student council the protagonist attends. The plot twist of the anime is that she is the protagonist's sister.
Considering Alex knows about Kill la Kill, as proven by several easter eggs, it's likely he decided to use the same plot twist for Yandere Simulator. Megami's design was changed to not give it away immediatly, but of course, Alex couldn't keep his damn mouth shut, so there are many, MANY details that confirm this theory. I said details ? I should have said pages.
However, I feel like a lot of people are glossing over many details about this theory, and have many misconceptions about it. Notably, about how Megami and Ayano are related. So I decided to give my own theory, including all the... uh... subtle evidences we get in the game.
Crazy Grandpa master plan
No need to beat around the Saikou family's bush (or should I say tree, wink wink), you probably know about the Saikou Grandpa eugenics tendencies. His goal is to create the perfect human being, and he plans on using that by acheving the perfect combination of genetics.
So you might not know about this, but there are two major theories about the development of an individual. It's nature against nurture. Is an individual as he is because he was born this way, or because he grew to be this way. Is a person a blank slate at birth, or is their individuality already present from birth. This plays into determinism, I won't go into more details for a Yandere Simulator dumb theory, but you can look it up if you're interested.
So, to go back to Crazy Grandpa, he was probably on the side of nature at first. He only reproduced after he found the perfect wife, as he didn't want his gene pool to be "tainted", going as far as to DNA her on random shit. How did he DNA test her in the 60s is anyone's guess but let's move on.
The result were two children, Ichiko and Ichirou. Ichiko was raised rather normally, and ended up leaving the Saikou family as she didn't want to become the CEO. Crazy Grandpa saw it as the failure of his belief in nature, and decided to switch to nurture with Ichiro.
So Ichirou was raised with high expectations, to the point he acted like a robot, but Crazy Grandpa was very proud about what he had become.

Saishou carefully designed a very specific upbringing for Ichirou in order to encourage the development of specific personality traits and interests, and discourage the development of any attribute that he considered to be 'unnecessary'.

The boy spoke formally at all times, never expressed emotion, and rarely changed his facial expression. The Saikou family's attendants often wondered if the boy was still capable of independent thought, or if he was simply an empty shell that had been trained to carry out his father's will." Beside that, nothing else is known about his personality.
Familiar, isn't it ? We also learn that this is Saisho's conception of an "ideal person".
It is mentionned Grandpa was the one to chose Ichirou's wife, with the same criteria as he chose his own wife. Again, a perfect wife, because he didn't want his son to waste all the work he had put to this point to have a perfect bloodline. To this point, grandpa got the living proof that nurture works, but he still can't let go of his belief nature plays a part in it.
If only there was a way to run an experiment that could give an answer to this question...
The theory
The sisters theory is that Megami and Ayano are sisters, but there are usually divergences on how they are related. Keep in mind that I will be using the old timeline from 1980s mode as a template. It's already inaccurate as Yandere Simulator isn't set in 2022 anymore, but in 2026. But I don't care, the events probably play the same way.
Megami and Ayano are revealed in this timeline to have been born in the same year. You'll notice that the timeline mentions the birth of "Ryoba's daughter", and the birth of "Ichirou's daughter". Keep in mind that Jokichi isn't mentioned as Ayano's father.
And that's where we come to the main misconception in this theory.
Who are Megami's parents ?
Ichirou is obviously Megami's father. However, many have theorized that Ryoba is Megami's biological mother. This theory goes both way, either Megami and Ayano are twins separated from birth, or Saikou kept an egg from Ryoba and inseminated the Wife. This would make her Ayano's maternal half-sister.
I don't suscribe to this theory. Well, first of all, considering the timeline, Crazy Grandpa was the one behind the deal we'll mention later with Ryoba. I don't think he would have wasted his time finding a wife with perfect genes for his son if he had planned for her to only be an incubator.
Also, another reason, Megami's little antenae. It's a part of her design that she gets from her mother. The Wife is also mentioned to have given birth to two children, Megami and Kencho, which wasn't a necessary precision. Alex would have probably found a way to circumvent this if she hasn't really have birth to Megami.
So no, sorry, Megami probably isn't a yandere.
So... if Ayano and Megami aren't related throught Ryoba... how are they sisters ?
Through Ichirou. Simply enough.
Yeah, as great of a dad Jokichi is, he is probably not Ayano's biological father. Ayano is a copy paste of Ryoba, so he doesn't share anything in common with Ayano design-wise, that could indicate he is indeed her father. We don't even know that much about him as an adult. The Characters page doesn't mention him being Ayano's father, he is only described as the student he was back in the 80s.
However, Ichirou is described as extremely similar personality wise to Ayano. While Ayano is probably emotionless due to the Aishi curse, she is way more stoic than Ryoba in her own mode. But that's still a weak evidence, this is way I will back this up with the timeline.
We know that Ryoba has given birth to a daughter very late compared to her own mother and grandmother. These reasons are said to be plot related and big spoilers. Again, Ayano's father isn't mentioned as a parent, only Ryoba.

I recently went through my text document that lists all character ages and birthdates and changed a few things. Aishi women now give birth at 18. Ryoba, however, gave birth at 31, for plot-related reasons that will be revealed in the true ending (or perhaps in the basement tapes).

So, this is my own theory on what happened.
Just shut up and tell us what happened already
In the timeline, it is mentioned Ryoba's mother kept her Senpai in her basement. In 1984, when Ryoba was still a child, Saikou Corp renovated all the houses in Buraza Town for free, including Ryoba's house. Why was this even mentioned ? Because it was the first meeting between the Saikou and Aishi families.
Crazy Grandpa found out about the weird shit happening in the Aishi's basement. He learns about the Aishi curse. He decides to keep an eye on the Aishi's daughter at Akademi. Everything Ryoba did to get her Senpai convinces him the Aishi gene is the perfect gene to create an emotionless heir.

Kocho is extremely reluctant to let Ryoba return to the school, stand on a stage, and hand her a diploma but was told by Saisho Saikou to let it go.

He orders his men to abduct Jokichi as an hostage, so she would agree to have a meeting. That's when they made a deal, that Ryoba would be the mother of the future Saikou heir. But not only is Ichiro not old enough, he wants to find the perfect wife for him. She can marry her Senpai and have well paying jobs in the meantime.
Ten years after that, Ryoba has a meeting with Saikou and his son. And according to Kencho, she is apparently a regular.

She walked straight through the waiting room and directly into Mr. Saikou's office, without even speaking a single word to the secretary.

How long had that woman been coming here? How often? What business did she have here?
Kencho asks the secretary details, and we are told :

The secretary was silent for a few moments, and then gave me some generic platitude about how "the details of Mr. Saikou's appointments must be kept strictly confidential."

So either Saisho fired the previous secretary, or this meeting must be extremely confidential. Because that secretary was a huge gossip when it came to Ichiro and Saisho's falling off.
We get the confirmation it is a big deal as all the employees act the same at the mention of Ryoba.

When they saw how distraught I was, they were eager to help, but...
...When I asked them about that woman who just walked by, they... their attitudes changed in a heartbeat.
They slowly turned away from me and returned to their work in silence.
They ignored me, as if I wasn't even there! I haven't been treated like that since I was a schoolboy!

It was as if that woman was a taboo subject that no-one was allowed to speak of...or that...
He asks about her several times but Crazy Grandpa shuts him down. Kencho mentions Ichiro was there for all the meetings, but he has only heard him speak a handful of times. However, we also know that Ryoba and Ichiro have spoken with each other.
2004, Ichiro is in his mid-twenties. He gets married to the Wife. That's when his two daughters are born : Megami is born to the Wife, as the official heir to Saikou. Ayano is born to Ryoba, away from the Saikou family, as the bearer of the Aishi curse.
How exactly what Ayano born ? It is unlikely Ryoba would have cheated on Jokichi, which is why many have theorized on an insemination. Considering Saikou is a tech company, it's not out of reach.

He had two children, in accordance with his father's wishes; 'One as a backup in case the first child fails you.'

Yes, this might refer to Kencho. But this might also refer to Ayano. After all, Saisho did have twin daughters, before having a spare...
One was raised to be emotionless. One was born emotionless. It was the old debate, nurture against nature. Which one would produce the perfect heir to the eyes of the Saikou ?
Crazy grandpa retires in 2019, right before Megami and Ayano enter Akademi, and Ichiro becomes CEO.
Ichiro wants to select the perfect heir. And for that, he decides he will select the one who will come out on top, between Megami and Ayano. He seals a deal with Kencho about Ayano.

There is...one tape...that I'm already prepared to part ways with... The tape I made after Mr. Saikou's recent, ah...demands. It's far, far too risky for a recording like that to exist... That one...must be destroyed...immediately.

We know this deal is about Ayano. When Kencho kills Ayano as he feels threatened, he says "Mr. Saikou, the deal is off".
Ryoba and Jokichi both work for Saikou. We know from the headmaster that Ryoba and Ichiro have frequent meetings. She is able to walk in his office regularly. Why ? To discuss their daughter.
When Ryoba announces they are going to America, and Jokichi worries about their job, she says she gave a call to their boss and "he was very understanding". I used to interpret this as their boss being scared of Ryoba. But if their boss is Ichirou, there might be a reason he was so understanding. If Jokichi and Ryoba were to get away from Buraza Town, they wouldn't get in the way of his plans.
After Ayano disposes of Osana, we get a cutscene where he is on the phone with Ichiro. He seems very pleased with the unfolding events, and tells Kencho these deaths are "necessary casualties" for the "progress of science". Normal CEO activity, nothing wrong here.
But Megami also learns about this, as she is aware of the presence of a dangerous individual. Either Ichiro told her, or she might have discovered it by herself. Ichiro keeps her away from school for several weeks. She attends school through Zoom.
In very early builds of the game, you could find a laptop in the school. You would get to see Megami as a shadowy figure, back when she still had black hair. And here's her monologue :

I know who you are. I know WHAT you are. My father won't allow me to attend school while you are... "active". He has a reason for tolerating your presence at this school. I don't. You are a vulgar creature that is only allowed to exist because you serve a purpose. If it was my decision, then every last one of you would be exterminated.

And here's the end of Megami's description.

Megami clearly has some very important information that would cause her to go to such extreme lengths...but what does she know? Does Saikou Corp have anything to do with it? And, more importantly, does Senpai have anything to do with it?

So yeah, that's it for me folks, I'm putting the tin foil hat away and going back to my regular activities. If you have any counterpoint or anything to add, please tell it in the comments.

I'm not talking about wearing your hair different or wearing young people clothes, but is there something in the DNA where autistic people age at a slower rate than the average person, like in the face?
I ask this because I was looking at selfies of myself from when I was like 16 and compared them to recent selfies (now aged 27), and I literally look the exact same? I'm not saying I look young for my age per se, but it's like I've just stopped aging? I know that's not going to be the case forever but I wonder if there's some kind of gene mutation or something more science-y to explain this
Maybe I'm completely wrong but would love to know if there's anything to research on this as I find it interesting
Let me know if you've had similar experiences

I always forget to move things around and end up killing a run stupidly. Copy DNA or Burnt Joker then forget to move it over to the x multiple joker before playing the next hand and then just losing because of it. Game needs an undo button. So many runs lost due to this. Please tell me I'm not the only one...

Click here to read my full article on POTS:
There is no one specific gene mutation that causes POTS. Rather, POTS is a syndrome that can have its genetic roots in various genes. Understanding where your genetic susceptibility lies may help you find your best treatment options.
For many people, an autoimmune condition (adrenergic system, angiotensin II receptor) triggers POTS.
The HLA genes code for an important part of our adaptive immune system. They help the body understand what is foreign (bacteria, viruses) and needs to be attacked. They also help the body understand which tissue is ‘self’ and should be left alone by the immune system.
Quite a few autoimmune diseases are linked to having different variants in the HLA genes. This HLA gene variation makes the human population resilient to lots of different and new pathogens, but this variation also makes individuals more susceptible to autoimmune disease.
Other genetic variants increase susceptibility to POTS in different ways. The genes that have been identified so far by researchers include nitric oxide genes, norepinephrine (noradrenaline) transporters, and the beta2-adrenergic receptor – all of which impact blood volume regulation.
SLC6A2 gene: codes for a norepinephrine transporter (NET), which removes norepinephrine from the junction between sympathetic nerves. NET impairment is linked to depression, panic disorder, tachycardia, and POTS.[ref]
GNB3 gene: codes for a subunit of a G-protein that is involved in signal transduction; thus, it can impact a lot of systems in the body, including metabolism and blood pressure. Specifically, this variant causes “enhanced vagal withdrawal of the heart” in relation to POTS.[ref]
Visit GeneticLifehacks.com and use your 23andMe or Ancestry DNA data to discover which genetic pathway is likely causing your POTS and learn research-backed lifehacks that target that pathway.

Hello,
I've been trying to understand the nature of cancer and its origins better. From what I've learned, cancer typically begins with random mutations in our DNA that cause cells to start dividing uncontrollably and eventually form tumors. However, one aspect that puzzles me is the apparent randomness of these mutations versus the commonality of certain types of cancers among millions of people.
If the mutations are truly random, how is it that so many individuals end up developing the same types of cancer, such as breast, lung, or prostate cancer?
I'm curious to hear your insights or if there are any recent studies that shed light on this topic. Thank you!

https://preview.redd.it/ij9pakqdu50d1.jpg?width=1287&format=pjpg&auto=webp&s=ed941e6555b1e8626d313f4952fd89e7a0214f6d
When Godzilla "Little Boy'd" Ginza, she got absolutely obliterated by the shockwave. Godzilla's cells got sprayed over her remains. When those cells started regenerating they accidently copied her DNA instead of Godzilla's. The Noriko we see at the end of the film is a completely new organism that perfectly copied her biology, hence the "Ship of Theseus". We know this is possible because Godzilla also started that process at the last scene.
However, growing black markings on her neck suggest that Godzilla side of her is starting to become more dominant and that in the next film she'll be even more "Godzilla-like". I would love to see Biolante in the next film but it is possible that Noriko isn't the only human effected by this and Takahashi Yamazaki might be planning to continue Hideaki Anno's vision in Shin Godzilla and create a Godzilla-Zombie army

A few days ago, I received a file from a journalist friend who teaches at a private university in Montevideo. I known this person for years now and the exchange with her on our countless bar nights basically made me want to try to study journalism. After I started my career we became even closer and we shared concerns about the evolution of information, social media and the infamous cerebral callosity we acquired to endure the tragedy.
My friend, let's call her Valeria, was part of a public competition to accompany a minor scientific expedition to the Uruguayan Antarctic base. Her thesis was about investigating how information reception behaves in remote and isolated areas.
I barely read it , but basically tries to show that information circulates and is received in a particular way in these circumstances by a group of unfamiliar people living under extreme climatic and isolation conditions, having as an example, life in submarines and in military bases in Siberia. The Antarctic base gave her the chance to observe some of her postulates up close.
Finally, she was chosen and traveled with this scientific group in a commercial flight Montevideo - Santiago de Chile to later arrive at Punta Arenas and fly to the Antarctic base.
The last communication I had with her before she sent me the almost 90 photographic captures of the Journal, was on March 15, 2024.
We talked over the phone about how the weather was in Montevideo, that it does not stop raining and the cars are practically floating on the streets. She told me that the transport that was going to take them back was having mechanical problems and they would probably have to order spare parts for the plane from Punta Arenas. Then She told me that it is freaking cold down there and his colleagues are all very boring. Nobody has whisky for the evenings. We laughed about that part because I told her to bring at least one bottle of Grappa in her purse.
Before saying goodbye, she told me they had spotted some old metal structures south of the base. The soldiers told her that it was safe to go near that part so she was going to explore them. It wasn't there when they first arrived and that the recent and atypical heat wave probably must have exposed it. I told her to be careful and we said goodbyes.
Three days later I received an email. “Valeria shared a file with you.” As I start to see what it was about she calls me.
“Mauro? MAURO!, can you hear me?” She said in a nervous and excited voice.
“I can barely hear you, what happened?”I asked half asleep, while still lying on my bed.
“Listen to me carefully, don't talk, just listen” I could tell by her agitation that she was walking fast or maybe running. The creaking footsteps in the snow could be heard in the background. in the distance, a catastrophe-type siren was blaring.
“Are you alright? What happened? What's that noise?” I said, now sitting on the edge of my bed.
“I sent you a file. Transfer it to a flash drive, delete history and reset your cell phone, the computer and your email address. I'll explain everything later, it'll be worth it.”
“What? What are you talking about Vale?, what for? Tell me what's going on - I started to yell at her, in slide panic.
“Listen, I found something that is not supposed to exist. In the diary he explains everything. I'm going back to the base, I think someone is following me, I set off an alarm or something. Save that file for me until I get there and remember that... “
There were two loud booms and the sound of water invading the transmission. A choked bubbling and cracking sound reminded me of ice collapsing. My friend had fallen into the water, in Antarctica.
“HEY, are you OK?! What happened?!” - I kept screaming hysterically until the call was cut off.
I looked at my cell phone for a second. My hands were shaking, I tried calling several times but the phone went dead. I looked at the compressed file. I jumped up and ran to the dining room furniture, frantically looking for a white flash drive that had to be in a drawer somewhere. I couldn't find it, so I went back to my desk. I pulled the drawer so hard that it came off the rail and fell to the floor. I started to dig through my belongings on the floor, coins, papers, cards, nothing.
I thought, I struggled to remember where I had fucking put it. Finally I saw my backpack peeking out from behind the desk chair, I jumped on it and in the second small pocket from the inside, there was a cheap white 16G flash drive. I put it in the pc, downloaded the file directly there, took it out and fabric restored the entire system on the computer. I do the same with my cell phone as Valeria said.
At the time I didn't even question if those measures really prevented me from being tracked, and the idea that that was the reason made panic run through my body like lightning. Sitting on the floor of my room next to the mess, my body was numb with tension. After a few seconds, I rebooted my cell phone to try to call Lucia, her sister.
“Hello?”
“Lucia, it's that you? I think something bad happened to Vale, I hear her over the phone as if she fell into the water, and some rumbling. I don't know what I heard, I think she got into some trouble or some place she shouldn't have been - I realized that I was mumble and not saying anything clear. For some reason, I didn't mention the file.
“It can't be Mauro, I just spoke to her on the phone. She was at the airport in Santiago de Chile at the boarding lounge, we talked for about half an hour, she told me she was bringing a fancy bourbon to share and…”
I stopped listening, it didn't make sense, how could it be? what the fuck is going on!
“Mauro, are you ok? Is something wrong? it's too early, are you sure you didn't dream it?”
“Did you talk to her? half an hour ago? But...,” I exclaimed without being able to hide my confusion.
“Are you... sure it was her?”
“Yes, of course you moron, it's my sister! Did you smoke pot again on an empty stomach?”
“No, you're right, nevermind, thanks Lucia, talk to you soon.” I ended the call without letting her say goodbye.
Had I dreamt about it? I erased everything now, how will I know if I dreamt it? I hesitated absurdly.
This is surreal, I thought to myself as I looked at the flash drive in my hand. I refocused my attention and went to the attic looking for my brother's old laptop he left me before going to live in Spain. It was practically useless, but it was enough to see the file. I turned it on, waited for the decrepit Windows XP to load, and put the flashdisk in, opened the compressed folder and found two files.
“LabNotes.pdf”
“PersonalDiary.pdf”
I decided to open the journal first. From what I interpreted from the loading order of the screenshots, after reading it, I opened the image of the last page.
I transcribe as is.
Day 243 of the 2nd mission 10: 40 am. March 12, 2019.
I am the head researcher of the Psychological Area at the UN Antarctic base; I'm currently assigned to Project Sisyphus categorized as the highest classified rank.
This is going to sound crazy, but the person living with my family is my clone.
It still surprises me when I say it out loud, but after being able to replicate the brain-muscular history (a perfect copy of our memory) of any person and having mastered replicating every cell of our bodies at any age, it was only a matter of time before the development of social biotechnology would emerge. Now and by worldwide agreement, as a complete secret.
There is absolutely no shame or a shred of ethics in what we do, there is no longer any constraint on what we can do to the subjects for the sake of research. That haunts me every day.
It all went to shit so fast, I doubt anyone will come to our rescue. The protocol says so, the base in the face of an imminent security risk will erase itself. The structure was designed to collapse methodically following a protocol of incineration and sinking. The immediate perimeter has underwater mines that make the ice collapse almost imperceptibly, but deadly to anyone who tries to leave.
No one can escape from the base, neither the research staff nor the subjects. Our place in the world is already taken.
I only hope that this journal along with my lab notes will be found at some point. I managed to construct a small insulating gasket for it so I trust it will survive in case this part of the building collapses as well.
Please use this data to let the world know what happened here and don't let perversity define us once again.
To my family: I love you and miss you every minute.
B.
At the exact moment I ended the reading I received a video call that made me jump with fright, it is...
Valeria.
With my pulse shaking, I answered the call.
“Hi you! The flight was delayed, can you believe it? This one is absolutely in my top three, worst trips of my life. I'm really hungry and everything is so expensive here. What are you up to? Tell me something, please, I'm soooo bored!”
I looked at her with confusion and I couldn't manage to pronounce words. When I was about to modulate an answer she interrupted me.
“What's the matter Mauro?, are you on pause? Is the signal OK? HELLO! Can you hear me? Can you see me?” She started to walk through the boarding lounge looking for better signal
“Yes yes, Valeria I can hear you.”
She laughed and looked at me with a face between sensual and serious, and continued.
“Do you miss me?” while raising the phone jokingly as she typically does in her selfie pose.
“Valeria, don't you remember calling me earlier today?”
“I? called you? Nop. Why? Ah! By the way, did you know there are penguins in Tierra del Fuego? I would have liked to go and see them.” She continued his verbose conversation in a carefree tone, with her typical hand gestures and playing with his hair.
“Well, at last!” She interrupted herself and shouted, jumping up from her chair.
“We are being called to board, see you in a couple hours!” She said goodbye with a smiling sonority, and began to walk towards the boarding gate.
But at the last second, before ending the call, her gesture changed. She looked directly at the camera with a hardened and emotionless face and almost mechanically, she whispered.
“(I'm going to retrieve that diary).”
My stomach dropped to the floor and I could feel as if my blood was running cold with fear. I could not shake the awful and eerie feeling that this person, who was returning, whom I had never in my life called by her full name, was not my friend.
So, the next couple of hours I put everything in to transcribe the rest of important passages of the diary. Something was compelling me to do it, i can't explain it, Some mix between moral duty, and morbid curiosity. Here is my selection of it.
Lab notes. day 96 of 1st mission 08:00 am December 22, 2016.
Subject JON X012:
First physical assessments: Normal, alert and inquisitive, exhibits some alteration to screens.
We place 100 cc of sedative in room air. The subject attentively follows the narrative of scenario B5 “The last mission”.
The subject responds positively to the premises of the story, where he is asked to address an audience threatened by a natural disaster, convincing them to choose a certain path out of the city.
He offers to collaborate but fails to articulate the message with the power to overcome the simulation.
We resort to pouring 125cc of concentrated Psilocybin into the air as stipulated in the protocol sheet.
The vocal frequency and body language reading receptors in the observation room are activated. The subject manages to formulate a series of premises articulately and with discursive power, circulating around the observation room.
Successful reaction.
We move on to the next stage.
Case is filed under the label “Jobs Project.”
Diary entry: Day 96 of the 1st mission 21:30 pm. December 22, 2016.
Today they transferred subject JON X0012 for psychological evaluation, several in the lab were very anxious about this arrival. I was never the religious type, but I can understand why. Truth be told,
I always imagined Jesus would be taller.
*********
Day 106 of the 1st mission 08:00 am January 02, 2017
Today we received a new lab assistant for the night shift. Much needed as I was covering these shifts myself and am really burned out. The underground operates at full power at those hours, the hum of the machinery becomes unbearable. This must be why the rooms have an insulating structure.
********
Day 112 of the 1st mission 19:00 pm January 08, 2017.
The new integration is not very bright. He labeled the transcripts wrong again yesterday and doesn't seem to fully understand the importance of these. I'm going to have to go through the whole method with him again. I don't have much patience lately, it's not his fault, he seems like a nice guy and it's real that I need a second of confidence. Better train him from now on. Maybe start a sketch of a short explanatory document.
*******
Small introductory guide.
When the subjects conclude the incubation and breeding process (pages 19 to 52 of the manual), that is to say, that they have at least remembered speech and with it, depending on the time in which they lived, reading and writing, they generally begin to perceive themselves. Just before situational curiosity is when the psychology department comes into action. Either to run the “stand by” simulation or the main tests.
In each subject's file is the target of their cloning, the era in which they lived, and the recommended scenarios to trigger the desired response. If the file has X amount on the cover, this corresponds to the generation of the subject, whether it is the first or 10th time it is incubated.
Generally, it takes between 2 and 5 attempts to generate the correct simulation, and administer the appropriate drugs.
It took 5 attempts to come up with the correct amount of methamphetamine that subject AH X005 (Hitler) needed to function in the scenario, as the correct amount bordered on overdose.
Simulations are much easier since the implementation of multisensor AI. We managed to generate almost any scenario including temperature, smells, lights and sounds. We tried not to use familiar ones, as human smells are impossible to replicate. We found this out in a complicated way. We tried to recreate a conversation between RR subject X003 (Reagan) and his mother, but he recognized the fakery by the absence of body odor. His mind collapsed and we had to move him to the Underground. The people in Area C (Private Clients) almost lost a very large Chinese account.
After calibrating the subject, we ran both psychological and behavioral tests, scanned retinas, analyzed blood, as well as vocal and body language. But what has really yielded surprising results are the free interviews. It is amazing what some minds are capable of with the right environmental and chemical stimulation. That's why transcription is vital (!!)
Our area develops BC (Behavioral Algorithms) which are then bought by the private sector, and some government agencies.
To give you some examples: Twitter was an idea of subject JO X008 (Orwell).
Bots in social media and the use of big data was an idea of JG X002 (Goebbels) and KM X014`s worst nightmare (Marx) was bought by Amazon.
It is an arduous process and the success rate is low, but when we achieve the goal per subject, well, these results are a mein part of the latest revolutions of mankind.
So follow the lab rules, never refer to subjects by their actual historical name, and always remember, they are assets, not people.
***********
Day 117 of the 1st mission 16:30 am January 12, 2017.
Today is a rest day all over area D. I miss many things from the old world that I thought I would never miss, taking a bus, standing in line with strangers, and today I miss Sundays. We only have one on the month. So as usual we gather in the rest area to listen to a liberated jukebox that tries to lighten the mood. I know, right? Why I wrote about this “Saturday” photocopy, well besides the same nostalgic drunks, I was approached by a person I didn't recognize.
From what I understood he was a rehabilitated alcoholic, maybe that's why I didn't see him on “Saturdays”. He must be in his 50's, he was portly and wore thick black-rimmed glasses, he seemed to have a slight limp, I noticed it when he went to refill my beer.
I am a very reserved person and find it hard to talk to people. Truth be told, I've lost the desire to talk to people here. What can you actualy fucking talk about here, if it's not about the same thing. Everything revolves around work and some inter-area gossip, which never escalates much.
But yesterday was Clara's birthday and to hide the remorse and sadness of only having shared with her the first 3 years of her life, I had a few too many beers.
We chatted about banal aspects of life in isolation, and the things we miss. For him it was going to the stadium to watch soccer with his grandchildren. I think it was loneliness and nostalgia that brought us together that night.
His name was Sigfried, I don't know if I spelled it right, but it was clearly Nordic, i notice because of some of the words he mixed up with English. He works as the underground level security manager. We all know that it is one of the most restricted areas and what we have learned in these almost 10 years in the project, is that the more restricted, the less questions you should ask.
But that day, I think I felt the urge to hurt myself, to go off the rails, so I asked what we all suspected but no one knew for sure. I asked about the blenders. I wish I hadn't.
************
Day 126 of the 1st mission 08:00 am January 21, 2017.
I almost can't express how furious I am today, but I'm going to try because if I don't, I'm going to punch the new assistant in the face. He has nothing to do with this, he's just mildly irritating.
Anyway, in Genetic Mapping or area A, they approved the incubation of another Anomaly. It seems to be an express request from a major shareholder and there is not much to say. Anomalies are very risky to reproduce, nature is wise, and for some reason it placed them in history moments where they had their limitations.
It seems that after the crisis of 2010 with “The Russian Devil” it is no longer scary enough. New school morons... If they had been there they wouldn't even dare to think about it. I AM FURIOUS.
The arguments are that this case lived longer, that the clone would be in his 70s, and that he possessed noticeably more “civilized” traits. As if the court of the last Zar had not been somewhat civilized.
Personally I think this is a big mistake. Since the discovery that some people possess unknown DNA components and with the 2010 background, they should draw the line. There are certain things, still beyond our ability to understand. But it is delusional of me to think that there are limits, someday the absence of them will consume us all.
************
Lab notes day 142 of 1st mission 08:00 am February 06, 2017.
Final free interview with JON subject X012
Scenario B-24 or “The Dinner Party” Result: Normal.
Notes: Subject is grateful, positive, docile and hopeful for the future. Offers to cook next time by asking for spices and ingredients of typical Hindu dishes.
The subject is directed to the Underground area.
Attached audio for transcription.
Case is filed under the label “Jobs Project”.
**********
Day 142 of the 1st mission 21:00 pm February 06, 2017.
Today was the last session with subject JON X012, I managed to extract the last retinal and body language readings, as usual before sending them to Underground level. We ran the dinner scenario, the truth is that is one of the best simulations we have achieved. The subjects are relaxed resulting in the best free interview environment. This one was no exception, I must say I understand the charm of the “messiah” turned out to be quite an entertaining subject. I hope his next generation will be similar.
**********
Day 152 of the 1st mission 19:00 pm February 16, 2017.
I was tasked with the continuous monitoring of subject NT X004. I am not at all happy with this transfer. First of all, I know nothing about area B of engineering and technology. Secondly, I still think this is a really bad idea.
One of the laboratories has been set up with the essential simulation equipment and personnel. Tomorrow we start with the calibration.
**********
Lab notes day 153 of the 1st mission 08:00 am February 17, 2017.
First interview with subject NT X004, we run simulation scenario 54-A, “Signal from another planet.”
Subject is observed to be receptive at first but quickly changes to paranoid. We administer 300cc of MDMA via air, according to protocol.
We introduce the reconstructed figure of a colleague in a cry for help speech.
The Subject laughs and doesn't believe a word, we move to a physical approach plane,
I volunteer myself with a room operator from the engineering area, we show him unfinished plans of an experimental vacuum propulsion engine.
He laughs again and tells us that we are not who we say we are.
We administer 50cc of DMT and move on to the next scenario.
From the screen an astronaut with non-human features sends a distress signal and intergalactic coordinates.
The subject looks thoughtful, reassesses, picks up the blueprints and begins to shout out values and what appears to be mathematical and physical formulas.
Air is charged with percentages of absolute sedation.
Audio recording is attached.
It is filed under the name “Project SpaceX.”
**********
Day 153 of the 1st mission 21:00 pm February 17, 2017.
I'm not sure what happened today, this is the first time in 10 years that a subject overcame the deception of 3 simulations. We had to place absolute sedation in the air, as risky as we know it is. I recommended that we restart the process from scratch, but it was a resounding no, the client is in a hurry.
I need to get more involved in this case to recalibrate the subject. I don't know if I want to. The words before full sedation still resonate with me. “are you still using DC current? interesting...”
**********
Day 154 of the 1st mission 21:00 pm February 18, 2017.
Something happened, I don't quite know what. The rooms have an emergency lockdown active. Outside hear security personnel mobilizing. I tried the intercom but it didn't work. The insulation prevents my screams from being heard from the outside. If this goes on another day I'm going to break the lock. I'm going to set my backpack to the bare minimum.
**********
Day 157 of the 1st mission 21:00 pm February 21, 2017.
Yesterday I heard explosions in the B area. I couldn't take it anymore and broke the lock. Whatever it was I had to go out and see. The corridors were dark, and the underground buzzer went on, at least that worked.
I went right to the north staircase, down the 4 floors in near darkness, the power was failing. The entrance to the underground area was barricaded but I managed to see a figure peeking out from inside as they felt me making noises.
It was Sigfried, he pointed me in the doors direction and I entered through a heavily armored side door. I was surprised by the immensity of this section, it encompassed a large hall below almost all the sectors of the base. In front of us there were 4 large industrial pipes with switches and multiple smaller pipes coming out of their bases. These were repeated like mosaics throughout the area until they disappeared into the distance in the darkness.
Leaning against one of them were 3 officers in formerly white coats and a nearly dead guard bloodied on the floor. Poor guy, his legs were crushed with his flesh in the open. He was lying in a pool of his own blood.
He had a blank stare and was panting, it seemed from the pale of his skin, that his fate was imminent. My asthma began to pound in my chest sharply, so I reached into my bag looking for my inhaler. I told them between visible gasps of bad breath to please tell me what's happened.
One of the doctors had a badge from area B and another from area E which corresponds to bio-armamentistics. The latter burst into tears and said “We deserve it, every one of us, we deserve it”.
I knew the other guy, he is an engineer in area B. I could hear him babbling almost nonsensically about, as why they never thought about it, an issue with electrical power.
He looked at me carefully as if recognizing me and grabbed me tightly by my jacket pulling me close to his face transformed for the panic.
“He let them out, all of them!” but not only that, no no no no... he told them the truth. Nikola fucking Tesla hacked us and told them the truth.”
He began to laugh frantically with a face of absurdity until he burst into a choked cry. At that moment everything went dark. The emergency lights activated, and from far away and getting closer, along with the emergency sirens that began to sound, we heard a large mass of people screaming and running through the corridors outside.
Sigfried looked at me as they started to pound on the shielded door and said.
“We're fucked.”
**************
Day xx of the second mission, month xx of 2017
“()The industrial sounds of spinning blades, the cries for mercy followed by the thunderous, liquid crack, down that big pipe, into the green barrels, with the Monsanto logo, dripped down one side an elongated drop of pink paste ending in the letter E on the chemical label. FERTILIZER.”
**********
After finishing the transcription, my whole body began to want to flee, the walls of my house were tinged with a faint blue light as the cloudy dusk came through the window, the lights turned off by my abstraction at the computer gave way to the dark corridors that began to feel alien. As I gently closed the pc my ears began to ring as if under pressure, my breathing became more present and the vibration of my cell phone interrupted my trance.
A call from the office. It was to tell me that I had a vacation week pending, that by schedule, I had to take it starting today.
Sons of bitches, now they even choose your time off - I thought at first, but at the same time I found the voice on the phone very strange, and to tell the truth, the procedure itself.
The anger turned into confusion that only added to the paranoia. The sounds in the street began to seem erratic, a chaotic and strangely familiar feeling came over me. My senses seemed increasingly acute, and they screamed:
Go away.
I grabbed the old laptop, the flash drive and headed for the bus station. The short trip from my house seemed like a long journey. People on the street looked at me with strange faces, the cell phone kept ringing with unknown numbers on the screen and a strange idea began to formulate in my head that whispered “Them, Valeria is one of Them”.
Already on the platforms I rummaged through my backpack where I confirmed that I had the key to the family beach house in San Luis, 60 km to the east of Montevideo. I turned off my cell phone, got on a bus heading to another and much far away town called Treinta y Tres. Sat near the last seat and slipped my cell phone in my front pocket of the seat in front of me, got off and commented to the driver with a clueless face, “I got confused, I'm going to the coast”.
I almost jumped onto the steps of the correct bus to where I was heading, unable to avoid the gazes of the passengers questioning me for the last minute drop in. I sat in my numbered seat and defragmented in dissociation, trying to understand what I was doing, I was running away, but from what?
The images of the last transcriptions were engraved in my mind, the last paragraph was repeated over and over again making me shake my head from time to time trying to get them away from my thoughts. The road was dark and I lost track of time, the digital clock within sight of the passengers jingling since we left, reading 10:40.
“San Luis Station!” - I heard the guard's shout in low volume.
I staggered to my feet, hurried to get off and with the same impulse I entered the dirt roads.
I zig-zagged through the dark, cold and silent beach town. The moonless night and the smell of the sea calmed me.
When I turned the corner to the gabled beach house of my family, on the steps of the front door lit by a white light, was her. Sitting, waiting for me. I stopped dead in my tracks and a chilling vertigo ran down my torso to my throat. We looked at each other for a short two seconds, until she stopped and started walking in sliding steps towards me, smiling and playing with her hands, crossing and uncrossing her arms. The growing sound of the wind through the trees covered us.
“Darling, how are you? How nice is the summer house, I don't think we ever came here, did we? Is it the one your grandmother left you?”
I felt the adrenaline rushing through my bloodstream, how could such a familiar attitude from such a familiar person transmit such panic to me? I had to answer something.
“Yes, this is it. I came to clear my head for a while, they gave me a few days at work and I wanted to take advantage of it.” I tried to excuse myself with failed dissimulation, since I stuttered in the middle of the words.
“Yes, I know! We arranged it with them, so you can be more relaxed and as a gesture for taking care of the file. Ah! and another thing. I think someone stole your cell phone at the bus station.” She looked at me with a smart-ass smile.
“Anyway, don't worry, they already found it on a bus on the way to “Treinta y tres”. You can get it back later.”
At this point I opened my mouth to ask for explanations, but as terrified as I was I only mumbled a “thank you”.
All this dialogue let us half a body length away, Valeria looked at me now a little more serious and stood at my side. She took my arm petrified and I could feel how a strong smell of neutral soap invaded me, as if she had rubbed herself in it too much.
“Shall we go inside? it's getting cold,” She said, finishing the sentence with a sweet gesture of pleading.
“Emm, shure.” I said.
My trembling hands managed to hit the lock on the 3rd attempt, we entered, turned on the lights and from his backpack she took out a red wine. Our favorite.
“Bring me some glasses, Mauro”. - She said to me as she sat down on the armchair against the window overlooking the gentle hills outside.
She poured wine until he almost filled the ex-cottage cheese glass, looked at me and in a toast gesture said.
“To... Dr. B?”
I slid a little smile and raised my eyebrows. Then I took half a glass in one sip.
“Well!” - She exclaimed, leaning over and resting the glass on the coffee table, and continued.
"You must be very confused, I understand, I saw it many times, the mind trying to adapt to a new, unsuspected reality and in your case all at once. It is not easy. First, make sure that no one is going to hurt you or anyone you know, second, what you read in that file, as you may have noticed, is not intended for public knowledge. Also to tell you”. I couldn't take the stress anymore, I exploded.
“You're not Vale. Who are you?! You're almost identical, but....”
“Ah yes, that one it's a tricky one to explain. Let's try, let's see:
“I'm a version of Valeria that she accidentally gendered when entered the lab. In one of the incubation rooms she touched a scan button that photographs her mind for 48 hours. It contains a micro needle that took her blood and thus generated me.”
“The thing is that we were in a situation of self-destruction of the systems, and that part of the programming code of the protocol was also copied in Valeria's mind.”
“And Valeria? She 's... dead?”
“Well, yes and no. If she tried to leave the base she's probably dead. if she's still there, she's probably frozen to death or killed by the cleanup command, but basically, if I'm here, she's not anymore.”
the coldness with which she answered me made me lose the little calm I had, I got up from the armchair and started to back away with my hands on my head, I couldn't stop repeating,
“this can't be happening, this can't be happening”.
“Hey! Mauro, calm down, it's going to be alright. I'm Valeria too. In every way, I'm still your friend, I know who you are and everything we went through, really, it's me, and when I finish managing the leak, the code, it won't work anymore, it will be erased from my mind and I'll be me. So don't worry. You only have to give me the flash disc and this issue ends here. We go back to normal life and nobody will know about anything.
“I'm not going to pretend that my friend didn't die! Alone, fucking freezing to death, I'm not going to let you take her place, I'm not going to let you!” - She interrupted me.
“Mauro, listen to me” - She came closer to me and grabbed my hands, her big, lined eyes looking at me with sweetness, like so many times before.
“I AM Valeria, I have the same fingerprints, the same blood, the same DNA, the same memories, the same scars, absolutely everything. Are you going to tell my mother that I died? to my sister? Are you going to report me? Nobody is going to believe you at all. If anyone even wants to believe you, how would you prove it? I am an exact copy”. - she told me, smiling with real sweetness and empathy.
I could only cry, for my friend, for the helplessness of the conclusion that she was right. I collapsed on the couch, and watched as the hills swayed in the night.
“Let's have the last glass and I'm leaving.”- she said to me.
“After I give you this, and that part of you disappears, will you remember that you are not... really Valeria?
“No, there is already a simulation on pause about Valeria's last week, she won't remember anything about this situation when she wakes up, because the memory is simply overwritten.”
“So I'm going to be the only one to know about this?”
“Take it as a gift Mauro, a glimpse behind the veil. And if you keep it that way, everything will be fine” - The threatening tone was soft but evident.
“Okay, hand me your PC and the flash drive.”
I looked at her evaluating all possible actions and if this decision was the right one, she stretched out her hand and smiled sympathetically. I gave her the old computer and the black 16G flash drive with the file. She inserted it, typed mechanically fast until the screen went black.
“Perfect, That would be all - She took out the flash drive, threw it on the floor and stepped on it violently with the heel of her shoe, put on his backpack and headed for the door.
“Stop,” I said.
“The things that Dr. B wrote... about the underground…
“Yes, they are true, it was the only way to be self-sustainable and to be able to isolate the complex from the rest of the world. Even the most morally flexible scientists would question the work if they knew where the subjects ended up, and what we were doing with their bodies... Anyway, I'm going home, Lucia called me 5 times already. Talk to you tomorrow.
“Love you,.” - She smiled at me and closed the door behind her. I felt a car slowly drive away from the house.
From my pocket I took out the white flash drive and looked at it. Now I had a decision to make.

Disclaimer: This post is merely to provide knowledge, and not to instruct you to do anything. Your choice whether to choose the Science One program at UBC or not is completely up to you. I hope this helps in making an informed decision.
I just thought I would contribute to the existing public knowledge of the Science One program already on Reddit here: https://www.reddit.com/UBC/comments/ec95t4/for_anyone_interested_in_science_one/ My post assumes you already did basic research on the program and aims to contribute more knowledge that isn’t publicly available yet (here is the Science One website: https://scienceone.ubc.ca)
I am an alumni in the 2023-2024 cohort, but just a disclaimer that a few things will change in the program in the years to come (see below):
Just a few small updates to the previous Reddit post:

• BIOL 140 is no longer a mandatory component of Science One so there will be no associated biology labs.
• There are three STT’s, where you can find here for the updated schedules for your year: https://scienceone.ubc.ca/resources

Note about grades: While Science One is promoted as a program where the students care more about knowledge than grades, while this is very true in my personal experience, I still think that grades played a large impact on our mental health, confidence, and our overall enjoyability of the first year experience. The reason I am including grades here is to allow you to have reasonable expectations about your grades and know that if you want to go into a very competitive specialization in second year, Science One may not be the right program for you. Note that the grades published on UBC grades (https://ubcgrades.com) is not representative of the actual class average. There is a policy where if a student failed two or more subjects in Science One, the credit for Science One will be broken down into its individual course components and the student will not appear to have been in Science One (it doesn’t show Science One on their transcript, rather the rough course equivalents). This raises the apparent class average reported. In my year, 3 people were removed, which changed the class average from 75% to 77%.
Alright, with that out of the way, I will be filling in the gaps of public knowledge specifically with the workload of Science One. Below is a (hopefully) unbiased perspective on Science One. My personal opinion will be stated later in this post.
Biology
Note: both of our biology professors (Pam Kalas and George Haughn) are no longer teaching in the program, so this subject may look very different

• Weekly 10 minute quizzes (quiz average 15% of biology grade), consisting normally of two to three written questions (be sure to learn to type very fast and think fast, especially since these quizzes are normally at 8:30am in the morning)
  • However, we get one quiz drop per term where our lowest quiz mark is discarded
  • Generally the quiz average is around 74%
• Biology Midterm “superquiz” once a term (20% of biology grade, can replace quiz average if the mark is higher so can be worth up to 35%) which is around 55 minutes and consists of around 10 long written questions (however, this is very little time for the amount of thinking and typing necessary to succeed so learn to type fast!)
  • Average was around 74% and 60% respectively for terms 1 and 2
• Biology assignments for completion/participation (10%) around once every 1-2 weeks ~ somewhat simple compared to the complexity of the quizzes and midterm, takes around 15-20 minutes per assignment
• Pre-readings per week around 2 hours, critical to understanding the class material
  • Pre-readings are found in study guides provided to us or on public webpages, there is no textbook for biology
• One tree project in term 1 where you are tasked with finding and identifying five different tree species around campus
• 2.5 hour final exam (50%), however, if you do better on your final exam than midterm average, it can replace the midterm average (so can be worth up to 85% of your grade)
  • Consists of written answers with explanations (I found this final to always be very rushed, finishing writing my answers with around 1 minute to spare)
  • Typically, since the final exams are so difficult, very few people will be able to get a higher mark on the final exam than the midterm
  • Average was 65% in term 1, term 2 grades not available

Overall: 3-10 hours of work per week depending on your thinking speed and how busy that week’s schedule is
Class average over the year: 71%
Term 1 Units: Great Bear Rainforest, Metabolism, DNA, Gene Expression, Genetics
Term 2 Units: Genetics (Continued); Phylogenies, Speciation, Population and Community Dynamics; Macromolecular Self Assembly; Regulation of Gene Expression; Biological Energy Transformation
Biology Tutorials

• Salmon project ~ year long project where we test the DNA of salmon through learning gel electrophoresis strategies
  • Very minimal prep work, maximum 30 min per tutorial

Chemistry
Note: One professor is no longer teaching in Science One (John Sherman), but the other is staying (Guillaume Bussiere), so this may be different in your year

• Around biweekly unit quizzes (40%), five per term, each quiz around 30 minutes, double sided with around 15-25 questions, with both multiple choice and written answer questions
  • Around 74% averages
  • One quiz drop per term
• Assignments (10%) consisting of worksheets provided in class (takes around 30 minutes-1 hour per assignment) and questions submitted on a paid ($70 if I remember correctly) homework submission website called Achieve
• 2.5 hour final exam (50%) consisting of theory based questions, organic chemistry, multiple choice, and calculation
  • 69% average in term 1, term 2 grades not available

Overall: 2-5 hours of work per week depending if there’s quizzes or assignments that week
Class average over the year: 75%
Term 1 Units: Chemical Bonding and Basics, Conformations, Stereochemistry, Thermodynamics, Electrochemistry
Term 2 Units: Kinetics, Quantum Chemistry, Intermolecular Forces (not really a whole unit, more like a supplementary lecture), Valence Bond Theory and Molecular Orbital Theory, Acid Base Chemistry, SN1 and SN2 Reactions
Chemistry Tutorials

• some coding based tutorials for quantum chemistry, little to no prep work, but knowledge of python coding is needed (but you will learn in Science One), submission of a worksheet for marks
• Organic chemistry worksheets, guided by the professors, but no submission necessary

Chemistry Labs (Chem 121, Chem 123 equivalents for term 1 and 2 respectively)

• Biweekly 3 hour lab sessions, where we are performing experiments and recording notes in our EDF
• Prep work: normally on our “off weeks”, we need to fill in our EDF and do the prep work (around 3-5 hours)
• In term 2, we also need to submit lab reports for each lab session (takes around 1-2 hours to write)

Overall class average (I forgot): around 85%
Physics

• Two long form assignments per term (20%, so 10% each assignment), each assignment generally consists of collecting data related to something learned in class, and analyzing it
  • Data collecting and analysis can take around 2-6 hours spread over the week (generally how long it takes to complete the assignment)
  • Around 80% averages
• Biweekly quizzes (30%), total 5 per term, one hour long open book online quizzes, consisting of 12 multiple choice or calculation questions
  • Around 75% averages
  • one quiz drop per term
• Prereadings assignments (4%) on WebWork (around once every two weeks, but very inconsistent schedule), consisting around 3-4 multiple choice/calculation based questions
  • Most often, there is no prereading assignment, but there are around 6-7 sections of prereading assigned per week of lecture of online OpenStax textbooks
    • Personally, I did not do them, but still survived, as the prereadings can take up to 3 hours depending on your reading speed and intended depth of read
• Homework assignments (6%) around once every two weeks consisting of 8-11 multiple choice and calculation based questions, requires a lot of knowledge of theory rather than plugging in numbers into equations
• 2.5 hour open book final (40%) consisting of both multiple choice (submitted on Canvas) and long written answer questions (paper copy, but submitted on Canvas)
  • 60% average in term 1, term 2 grades not available

Overall: around 2-5 hours of work per week depending on if there’s quizzes, long assignments, or assignments
Class average over the year: 76%
Term 1 Units: Measuring and Modelling Motion, Motion and Conservation Laws, Thermodynamics, Rotational Motion, Special Relativity
Term 2 Units: Waves, Quantum Mechanics, Electrostatics, Circuits, Magnetism and Magnetic Fields, Stellar Nucleosynthesis
Physics Tutorials

• Generally working on worksheets with the guidance of professors, very helpful for understanding the content better, but worksheets are not submitted

Physics Labs (Phys 119, Phys 129)

• 3 hour sessions per week, consisting of data collection and data analysis, learn plenty of Python and basic statistical tests (however, most labs in term 1 are very rushed, but in term 2 there is much more spare time)
• Prep work in term 1 takes around 1-2 hours per lab, consisting of submitting a Jupyter notebook with code so we understand the code we need to use in the lab
• Prep work in term 2 takes around 15 minutes - 2 hours, mostly doesn’t have as much prep work as term 1
  • Rarely Jupyter lab notebooks for submission, most weeks we just preread what we are doing in the lab and that is sufficient

Class average (I forgot): around 85%
Mathematics

• Midterms “tests” (25%) three per term, around 50 minutes, and consisting of 3-4 written questions (average is usually around 60%, but we have had two instances of failed average midterms resulting in scale [but don’t rely on a scale, it is very rare!]), however, we get one midterm drop per term, where it is not counted in our average
• Assignments (16%) consisting of three long assignments with written answers that take around 2-4 hours to complete, and weekly two WebWork assignments that are around 6-12 questions, calculation and theory based
• Weekly quizzes (9%), with one quiz drop per term
  • 15 minute quizzes with 3 questions, generally a little rushed but doable
• 2.5 hour final (50%)
  • Average 67% in term 1, term 2 grades not available
• Pre-reading assignments not for marks, takes around 2 hours per week (personally I didn’t do any and I was ok)

Overall workload: around 3-6 hours per week depending if there’s assignments, and midterms that week
Class average over the year: 72%
Term 1 Focus: Derivatives and ODE’s
Term 2 Focus: Integration
Term 1 Project (partnered)

• consists of a presentation and mind map of a topic that we research in depth using primary literature
• Around biweekly meetings with our mentor, and mini check in assignments

Overall workload: around 1 hour per week, but can be up to 4 hours when preparing for the presentation
Class average: around 85%
Term 2 Project (partnered)

• consists of a project designed personally by you and a partner to measure something and report on it in a 3000 word paper (90%) and a presentation to our peers (10%)
• Weekly check ins with mentor, or round table discussion with updates

Overall workload: anywhere from 0-8 hours a week depending on the complexity of the project
Class average: 75%
Summary
With that in mind, I want to provide some pros and cons of Science One:
Pros

• Unique connections to professors
• Community with fellow students, and can form a very close knit group of people who are like-minded
• Blended grade at the end of the school year, so if you do bad in one subject but good at the rest, you can “hide” the bad mark
• Networking with professionals at guest speakers
• Having all your classes in one classroom, to avoid rushing across campus between classes
• Allows you to see how all science subjects interconnect
• Provides a deeper knowledge of all topics, basically an honours version of first year Science
• No stress about designing your own timetable
• Research experience in term 2 project can help with research applications in the future
• Study spaces for only Science One students, very helpful especially during finals season

Cons

• grading is a little harsh (very harsh in biology in my opinion) and there is no scaling at the end of the school year, so you may not get into your desired major if it is very competitive to get into
• You also are not prioritized for major selection compared to mainstream (ie if you get a 70% and a mainstream student gets a 71%, they will be prioritized)
• Workload is very intense, sometimes it felt like there was no break for ourselves
• Mental health and stress levels
• Blended grade at the end of the school year, so if you do really good in one subject it may be hidden
• Busy workload means less free time, so some relationships outside of Science One may dwindle
• Very hard to take elective courses on top of Science One, because of the busy schedule and demanding workload (might make it harder to get into Computer Science because of its prerequisites)
• Science One only offers 28 credits (6 for two terms of, biology, physics, math, and chem each, with 2 for two terms of chemistry labs and physics labs each), meaning that our term 1 and term 2 work do not provide us any credit
  • Science One disqualifies students from taking SCIE 113 (a communication requirement), but does not give any credits for it

Personal Opinion
While I did enjoy Science One at the start of the school year because of the pros mentioned above, over the school year, I started taking an interest in a competitive major, which put a lot of stress on myself to achieve high marks. It almost felt like no matter how hard I tried and how well I thought I knew the topic, my mark was going to be low anyways because the way the content is tested. I feel like I shot myself in the foot when it comes to getting into my major as the application process is completely based on grades.
While I don’t know if I would have done better in mainstream (I probably wouldn’t have had as many friends, and therefore my mental health would be worse, and possibly it means that I don’t have as much motivation), I definitely think that I could have done better in mainstream if I had the same motivation I do now as their way of testing and marking may be a lot more lenient. However, I am almost certainly sure that if my cohort were placed into mainstream classes in first year, we would have achieved much higher grades than we did in Science One. However, I don’t know if being in Science One could have an effect on my performance in the years to come. I do acknowledge that over the year, I was able to develop really good study habits to manage the workload and also learned to prioritize my health, which will be beneficial in the future.
However, I have also noticed that there are some “hell weeks”, where we absolutely feel like dropping out. In both terms, after term 1 and 2 conferences, where we were away at camp for the weekend (we didn’t have the weekend to do schoolwork), there was a week where there were many overlapping assessments, such as math midterms, chemistry quizzes, math assignments, and chemistry assignments, etc. These are the assessments that ended up having class averages which were below expectations, which I feel wasn’t our fault at all.
In fact, we were burnt out, but because of our wonderful Student Council, we were able to have some assignments pushed back to alleviate some of our workload and reduce burnout. Special thanks to our chemistry professors, as they were always open to planning the chemistry quizzes on days that weren’t as bad for us, and even asked us which day we wanted the quizzes. I can tell they really care about our wellbeing and our performance.
In addition, even though Science One is marketed as being prestigious, most of the people I talk to don’t even know what Science One is, and the few who do know it, know it for its intensive nature and harsh marking scheme. There is no special treatment for Science One graduates that I know of except for the occasional “wow how did you survive?”.
Generally, I don’t regret doing Science One, but if I had the chance to restart first year, I would have chosen to go the mainstream route. I feel I would have been a lot less stressed and have gotten much better grades. However, I did meet so many motivated and amazing people this year, and have generally enjoyed some aspects such as camp. Unfortunately, because of my desired major, I have seen Science One as something that may have limited my options in the future.
Do I think Science One is for you?
These are my personal opinions and please don’t take this section as the final decider for you. Be sure to do more research!
To succeed in Science One, talent can only go so far. At some point you will be challenged academically, and you will doubt yourself. But what follow is what really determines if you are a good fit for Science One. If you want to give up and do something easier, go to mainstream. If you want to persevere and to learn more, Science One may be the right choice for you. If just you want the prestige of Science One, don’t do Science One, it is not as well known as their website may make it seem. If you want to go into Computer Science, Science One may not be for you since it has little connection to Computer Science and really lowers your mark.
If you really are hard set on a competitive major which requires high marks, consider mainstream, since it is very rare and very very difficult to do well in Science One. If you really love to learn more difficult concepts, have a tight community to be by your side, to have good connections to your professors, to get some research experience, AND grades aren’t a huge concern for you, Science One is for you.
Again, take my opinion with a grain of salt. You are ultimately the right person who can make the right choice for yourself. You know yourself the best. I hope this helped and I wish you all the very best in your studies, whether you decide to go Science One or not. Feel free to DM me or reply below if you have any further questions :)

I recently made a post asking if people preferred mutated or more conventional zombies.
It sounds like the majority prefer walkesprinter types. However, not smart zombies or mutated ones such as brutes.
I’m making a passion project novel, so I don’t mind about sharing my concepts or being a bit controversial. The premise is its the year 2025, effects from the covid-19 vaccines have now started to show and the vaccine has altered peoples DNA turning them into zombies. Not everyone is affected that had the vaccine only one specific brand, which is still majority of the population. Our protagonist is unvaccinated as he is hyper sensitive to an agent in the vaccine. Individuals that got the first vaccine from said brand will become walkers, second shot will become runners, and the third shot/booster I remain undecided on after my recent post. 4/5th shots all died.
As I said it’s a passion project. However, I would love some suggestions on if you think this is a good concept from the beginning of a zombie apocalypse? What do you think people with the boostethird shot should behave like? Do you feel it would make more sense if the order was reversed, meaning that people with only the first shot would have ??, second shot would be runners and third/booster shot would be walkers?
I will emphasise its a passion project and I have no agenda in relation to being vaccinated.

Not a “crazy-good“ seed, but a “crazy-wtf-is-happening” seed.
Seed for those interested in trying it for themselves: R82BAF5L. I was on Magic Deck Gold Stake.
This seed starts with a Rental DNA and an Eternal Hologram in the first shop. Immediately incredible.
Then, after the first Ante, there’s a Spectral pack with an Incantation, making Holo way more useful.
Then, you suffer the curse of “oops, no Mult” because you have zero money because of DNA going out back and breaking your knees. So naturally, rather than saving up slowly and finding Economy Jokers, copy the Gold card from the Incantation and spend everything over Interest to find a Mult solution (and on Standard packs).
Watch as every Mult solution you get is either Perishable, Rental, or edible, and begin to despair.
Then, from the corner, comes Rental Vampire. The deck has ridiculous amounts of Enhancements from the DNA and standard packs to boost Hologram (which were also a desperate attempt to find an Edition to DNA). Then cry as you realize that you have 2 economy-based scalers and 2 Rentals (3 counting the emergency Popcorn).
Except that’s not enough, because the best Mult solution all run appears. It’s Foil, it’s got great scaling, and your Popcorn is almost dead. It’s Ceremonial Dagger. Another economy-based scaler. And it’s a mandatory take because there is no better option.
The only reason all of this works is the absurd amount of Gold cards that got DNA’d. The worst possible strategy somehow enabled this absurdly stupid run.
Somehow, some way, with the aid of an Invisible Joker, the game is finished with a +34 Dagger, a +56 Dagger, a X7.25 Hologram, and a X4.1 Vampire.

My mom has two copies of the MTHFR A1298C gene. Prior to menopause she was always very thin; she says that she underwent menopause when she was 59, and in 2011 (when she was 59 years old) had a BMI of 20.0. She started slowly putting on weight in 2012 and crossed over into obesity during 2014, reaching a peak BMI of 35.2 a few years ago. She's lost a good amount of weight since then with her BMI currently at 29.3 (overweight rather than obese, though still close to Obesity Class I), thanks to receiving testosterone pellets every few months along with using Semaglutide, but she seems to have hit a plateau the past year or so. Could the MTHFR gene be responsible for the plateau? And do MTHFR mutations sometimes only cause significant weight gain after menopause? She's made a lot of progress, but she developed asthma symptoms in 2014 when she crossed the obesity line. Her asthma symptoms have become milder the past 2-3 years thanks to losing around 40 pounds, but I think she'll need to lose an additional 15-20 for them to go away entirely since that will bring her back to her 2013 weight (she never had symptoms at any time before 2014). Around 60 percent of people have their asthma symptoms go into complete remission with weight loss, and she probably fits into that demographic given that her symptoms have already become a lot milder, though they're definitely still present and not negligible.