Good evening team!
The case for Annovis Bio, Inc.(ANVS) is a strong one. I’ll try to be brief, but will link resources for those who would like to further investigate on their own.
Annovis Bio Inc. is a pharmaceutical company developing a revolutionary drug platform to treat Alzheimer’s, Parkingson’s and other neurodegenerative disorders. Alzheimer’s and Parkinson’s are the 2 largest unmet treatment needs of the ageing population. The catalyst associated with this piece is the company’s Phase 3 - Parkinson’s Disease trial, which the company will report results for in June of this year.
Why did the value of this stock drop so dramatically? There was a delay in presenting the findings of the study due to an anomaly in patient blood tests, which has now been explained to the satisfaction of the FDA. The delay caused a panic selloff and some shorting, which is what initially tipped me off to this chart. With the FDA’s approval of the data and the past findings in Phase II showing an increase in motor speed and control, it appears the stock is ready for a huge comeback.
It’s also worth mentioning for those that are interested in a long term investment that the company is at various trial stages for multiple neurodegenerative conditions (see below graphic) and Buntanetap is the only drug so far to show improvement in cognition in Alzheimer’s patients and motor function in Parkinson’s patients.
https://preview.redd.it/edjuer5kc90d1.png?width=614&format=png&auto=webp&s=b6977ac6fdeb43f90042dcfaecb273adf7d73887
What role do Neurotoxic Proteins play in degenerative disorders and diseases?
https://preview.redd.it/bmh02xfmc90d1.png?width=468&format=png&auto=webp&s=ca4633ef9af2ae0151f1ac513c62dd162c7fe36a
Does Buntanetap show improvement?
https://preview.redd.it/pvfx8p6qc90d1.png?width=614&format=png&auto=webp&s=a6545cb25d3a62ff95ab281accfefd1a00c2ea5f
https://preview.redd.it/llsfqhwsc90d1.png?width=611&format=png&auto=webp&s=e683996e8be4c65cea080ebbb55d2c37f40db357
https://preview.redd.it/x4h4iwwvc90d1.png?width=620&format=png&auto=webp&s=407d1af5c322e9c16cba21e25d0429ec4969a805
Investment Highlights:
https://preview.redd.it/pvyar4pyc90d1.png?width=587&format=png&auto=webp&s=fb172b912f56cd38a65d51d53f41301b5e5eb7d3
On the technical side, the stock seems to have already hit the bottom and bounced back, beginning a new upward trend:
https://preview.redd.it/jl1cti62d90d1.png?width=1050&format=png&auto=webp&s=57c11ebde6c29bab39c1e00cce1c43986d41c6e1
The stock has a 1 year price target of $23, which I feel is going to be hit fairly quickly once the Phase III Parkinson’s results are disclosed.
For those interested in short squeeze potential:
https://preview.redd.it/7bqp2ye7d90d1.png?width=540&format=png&auto=webp&s=b0f176be954b659f96bc201cd18716f6d765f8ca
https://preview.redd.it/ny6ieg4ad90d1.png?width=1417&format=png&auto=webp&s=9984a1f0ed8e03f56def82e2e0886d132d1bc032
https://preview.redd.it/lbw4eo2cd90d1.png?width=1491&format=png&auto=webp&s=b1c613bfd096bf92f80f5922ffb72ade827eea39
As previously stated, the main catalyst for this stock is expected in June, exact date is not specified. It could be a slow grind up, or investors may become aware of this opportunity and decide to jump in early.
I have decided not to cross post any of my picks. I’m only going to post them in PhaserTargetRange and let the history of my picks speak for themselves and allow this tiny at the moment subreddit to grow naturally based on performance only.
Please perform your own research before investing in anything.
Company Website:
Annovis Bio
(Excellent) Management Team:
ABOUT US ANNOVIS BIO
Presentation:
PowerPoint Presentation (eqs.com)
Our Science:
OUR SCIENCE ANNOVIS BIO
Understanding the tests referred to in the studies:
Weschsler Adult Intelligence Scale: 4th Edition (WISC-IV) Pearson (pearsonassessments.com)
https://alzres.biomedcentral.com/countepdf/10.1186/s13195-016-0170-5.pdf
MDS-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) (movementdisorders.org)
Interview with CEO:
#330 - Dr. Maria Maccecchini, CEO at Annovis Bio (youtube.com)

Some quick memes to give an idea of their culture and broader actions
From the flames of Prometheus rises Mankind forged anew
“Hear the sum of the whole matter in the compass of one brief word — every art possessed by man comes from Prometheus.”
The History of the Promethean Republic was one born out of tragedy as millions looked onwards into space in shuttles to the outerworlds of UN colonized space with the promise of new life and settlement freshly dripping from their ears. When they arrived they were betrayed by these honeyed words as enmasse they were enslaved and subjected to mutilation and augmentation on a scale never before seen. The cries of millions silenced by the chatters of trillions of others in the stars.
These betrayed were historians, mothers, fathers and scientists hoping to explore new frontiers only to be subjected to this by corrupt or rogue UN governors and industrialists looking to make a quick buck off of an “efficient” work force. They hoped to scrape away their free will and ability to rebel and leave only obedient and subservient “automatons” who while less physically capable than the cheaper robot would be more adaptive. Amongst those who betrayed them however was a man known as “Charon” who horrified at the deeds of his fellows set out to right what went wrong and bring the millions of people annihilated back.
He would succeed but not in his lifetime as the title was merely one passed on to others like him. The various Charons subtly sifted through code and memories to try and identify what little he could bring back. It took the Galactic civil war between the LIS and UN to give them the right time to act. And so the cyborgs arose unleashing a massacre not seen since the French Revolution upon their slave masters after decades of encountering others they would realize that humanity was unlike them having retained their flesh and minds while also unwilling to accept them back into the fold.
So emerged the Republic of Prometheus which would stand as the Cyborgs attempted to recover what they could of themselves and others. Some had awoken from their slavery to find their young children they took with them on their trip dead killed by their unrepentant slave drivers who saw little use or thrown into orphanages by the few with any semblance of a moral compass. Many tears were shed as children fled from their mangled parents and their steel husks as they said a rambling name that sounded semi-intelligible for their own. Prometheans disgraced and horrified vowed to stay in isolation in the hopes that maybe their children would have been better off without them.
A myth of the “Republic of the Dead” emerged as the centuries went on of a region of space where the dead still walked.
The prometheans eventually began to rebuild themselves and forge a new society one built around some semblance of patriotism and liberty. Eventually they developed from their faulty memories and eventually their own capabilities means of communication amongst each other via cybernetics with that the need for election dissipated as referendums took their place. The Prometheians could be regarded as of now as either the first cyber-democracy or perhaps a democratic technocracy.
This would not dissipate as they founded their state religion, the cult of Libertas. By this point Charon and Prometheus had merged in their minds as one being with Prometheus developing into god in their eyes as the one who struck down betrayers and uphold oaths. By this point of course Charon had long perished having left to his home planet after the insurrection. Prometheus is a loving albeit harsh father who intends to force humanity to advance as one and despises “parasites” who prey on the week and advance only for themselves.
He did leave them three principles: -The Principle of Spartacus(Unity), which was to uphold and embrace all members into their community in exchange for fully loyalty. It has also been interpreted as communal openness or universal brotherhood. -The Principle of Brown(Liberation), to end injustice wherever it may be and to liberate the people. It has also been interpreted as loyalty to god’s equality. -The Principle of Prometheus(Knowledge), the easiest to understand is to actively study the world both scientific, historical and cultural as well as to disseminate it beyond.
While on paper positive the cult has by this point expanded to mandate cybernetics, worship of the three principles and universal mandatory service as well as a notoriously loose code of ethics. Notably including hiding information regarding medical research from participants till after the study has occurred, coercion via pay and even including prisoner coercion. When questioned they would merely state the individual has no free will as no man has accomplished anything by themselves with deviations from community norms often shunned. There is also the issue of the void whom many have started to regard as the personification of Prometheus to be freed while others denounce it as the being that had brought this corruption to the world and must remain imprisoned as per its punishment.
It is not without its progress as work on stem cells previously slowed by regulation and cybernetics have exploded leading to a population regarded by many as technically immortal and without pain. Food is surprisingly abundant thanks to advances in Hydroponics and lower demand thanks to how far some augmented have went.
The army is entirely adhoc largely composed of self-funded and organized militia charged with rooting out slavery, banditry and hostile forces at home. They would often engage in expeditions with state approval to liberate planets dominated by slavers and leave after transitioning power to the oppressed albeit often with a hefty booty of loot. These newly liberated planets deemed to be in the Promethean security network would find themselves guaranteed by the Republic and offered annexation at a later date pending referendum. However in case of invasion or an offensive war the state bureaucracy following a referendum authorizing it would select a Supreme Commander who would then select his subordinates who would then assume control of the various militias.
Politically the dominant faction is the isolationists but two increasingly vocal interventionist factions have emerged: The Blues and Greens. Blues support a diplomatic approach gradually uniting the various planets underneath a cybernetic democracy and supplying technology as well as economic aid to develop them and build goodwill. Greens view humanity has squandered their inheritance and that their “elders” must take charge to guide them back to glory at all cost.
Glory to Prometheus, Spartacus and Brown!

A hungry bear does not dance
Patriarchal Cathedral of St. Alexander Nevsky, created in 1913. The city of Sofia went through changes according to the vicissitudes of Bulgarian history. Many rulers ruled it and each of them left their special stamp on the soul of the city. The large Jewish community that lived in the city also left evidence of a glorious past.
The Bulgarian people are one of the oldest peoples in Europe, with a cultural continuity of 1300 years. Information about Jewish settlements in Macedonia dates back to the time of Gaius Caligula and in the Nicopolis district a Latin inscription was found that testifies to the existence of a Jewish community in the 2nd century. There are not many other peoples on the European continent that formed so early and preserved their language, their religion, and their national tradition. The English, for example, completed their consolidation into one nation only after the Norman conquest in the XI century, and the Germans and Italians in the XIX century. The formation of the Bulgarian people was the first swallow that heralded the golden age of the Slavic peoples and kingdoms; In Russia a century later the inner Principality of Kyivan Rus was created, and in the Balkans two centuries later the kingdoms of the Bosnian Serbs and Croats were formed. The word Bulgarian itself means "to do good". Bulgarians have three important characteristics according to their own myth - from the Thracians they believe they received the sympathy for mysticism, from local Turks they bred with their fighting ability, courage and determination, and from the Slavs - patience as a way of life and mutual guarantee to each other and to other Slavic nations.
However, this wonderful cultural continuity was disrupted with the Ottoman occupation in the 14th century - which succeeded in destroying the local aristocracy, destroying the cities and fortresses, and deeply damaged the original organic Bulgarian culture while preventing for a time the formation of the Christian urban culture that developed in the same period in Western Europe. Therefore, unlike in Italy, England and France, ancient cities from the Middle Ages were unfortunately not preserved to modern times. In addition, Bulgaria did not experience the Renaissance, the Baroque, the Enlightenment period, and only in 1878, upon gaining independence, did it begin to rediscover its powerful roots.
In the years following independence, Bulgaria became increasingly militaristic and was often referred to as the "Prussia of the Balkans", in regards to its desire to change the Berlin Treaty through warfare, when the division of territories in the Balkans by the Concert of Europe regardless of ethnic composition led to a wave of discontent not only in Bulgaria, but also in the nations who were her neighbors and Bulgaria strived with relative success to manage the power relations compared to the other Christian countries of the region.
The defeat of the Ottomans in the Turco-Italian War, and the feeling that this was the time when Christian territories could be conquered from the Ottomans, led some of the Balkan countries to create the Balkan League, in which Bulgaria served as a central player. The First Balkan War began when Montenegro declared war on the Ottoman Empire, and a few days later the other members of the League officially joined the war. During the war, the Allies managed to conquer large parts of the reminder of Ottoman Europe, with Bulgaria in particular suffering huge losses in combat operations.
These territories were taken from the Empire in the Treaty of London that ended the war. However, League members failed to reach an agreement regarding the division of the various territories, and against this background, the Second Balkan War broke out.
In the second war, Bulgaria fought against the other members of the league. The war against Bulgaria was even joined by Romania, which was afraid of a large-scale Bulgarian sphere of influence. At the end of the war, in the Bucharest Agreement, all of Bulgaria's gains from the previous war were completely erased, except for a coastal strip near the Aegean Sea that remained in its hands. Part of the Dobruja region passed from Bulgarian control to Romania, Greece received the territories of Thessaloniki and Serbia received Macedonia. As a result of these changes, the main power in the Balkans shifted from Bulgaria to Serbia.
Thus when the Great War began Bulgaria joined the German Alliance with the hope of receiving territorial gains, and indeed it was generously rewarded by the Germans following the end of the war – with most of Serbia being transferred to the Bulgarian Tsardom and the entire Black Sea coast taken from Romania back to Bulgaria at the International Peace Conference of the Hague. The new territories brought new hope to the Bulgarian people, who prospered in these post-war days due to an economic alliance with Mitteleuropa, and as result, the Bulgarians did not bother to hide their sympathy for the Germans, even after the 1929 German economic crash and when it seemed that the established world order was beginning to crumble as more and more powers became Integralist and avowed anti-German. At that time, the reported German pogroms did not affect the Bulgarian domestic policy - which continued to allow a rich cultural life for Bulgarian Jews.
As a token of gratitude to the Germans and out of fear of a non-German Europe that would be hostile to them, the Bulgarians quickly and almost automatically joined the German side in World War II. In retrospect, contrary to the results of the Great War, the Tsardom got the short end of the stick and suffered a colossal defeat.
Although the Bŭlgarska armiya was relatively well equipped for the Serbian and Albanian threats and even advanced directly to the Serbian city of Niš, difficult terrain conditions soon made the front static along with reports of abuse of Serbian prisoners of war. The Greek declaration of war on Bulgaria which concerned many was merely only the beginning of bad tidings, each one greater than the other.
Eventually Romania declared war as well almost a year into the start of World War II. The Bulgarian army simply could not deploy on so many fronts and received encirclements one after another, as the Romanian invasion was unrestrained and ruthless. In less than a month and a half afterwards, all of Bulgaria was conquered. With no other option, the Bulgarian government announced unconditional surrender to the Pact of Iron.
A new puppet government was established which received all administrative dictates from Paris and Bucharest while the Tsar was found dead by suicide, in a clear indication of the national situation.
Pact soldiers were allowed to loot whatever they needed, and Bulgarian national historical works were transferred to other countries. It was the darkest period of the Bulgarian people, who experienced quite a few tragedies in the past.
And an even darker period for the Bulgarian Jews, when in 1944 the government approved the request of Russia and Romania to transfer 11,343 Jews to "labor camps" after a preliminary "deportation" of 9,000 other Jews (the extermination of the Jews in the Holocaust often received such titles, although those who ''discussed'' the request knew what it was truly about – an extermination camp).
However, hope can be found even in the most difficult moments. As the Germans eventually got closer to Bulgaria, the Bulgarian people revived the guerrilla action against the local Pact forces. Bulgarian public figures protested after the expulsion of the Jews of 1944, among them the Bulgarian Orthodox Church, bishops and parliamentarians and managed to prevent the deportation to extermination camps of about 48,000 more Jews before the liberation of Bulgaria by the Kaiserliche deutsche Armee while the survival rate of the Jewish population in Bulgaria was among the highest of controlled Pact nations. On February 1, 1945, hundreds of Bulgarian Pact collaborators were executed by German forces in an event that received international condemnation and Bulgarian silence. Bulgaria emerged from the war with a terrible sense of loss.
The brief period of complete German military occupation ended sooner than expected, when both the Americans and the Germans reached agreements on the re-creation of the Tsardom with Macedonia once again returned to Bulgaria in the Treaty of Aachen. In those days, Bulgaria still needed German economic and military support to prevent anarchy and enable basic functioning and so it suffered after Operation Halfmoon despite not being classified as an enemy nation for the purposes of the operation. Therefore, it did not show any opposition to the American soldiers who came to manage and start the rehabilitation of the region, and cooperated with them as Secretary of State Grew was able to finally settle the territorial disputes that led to almost a century of tensions and wars in the region with virtually all (devastated) Balkan countries signed the Sofia Agreements in exchange for participation in the ''Grew plan'', as they formally committed to ceasing and ending any territorial claims and opened full diplomatic relations with each other.
“Efectul știrii este mai important decât adevărul ei.”
https://preview.redd.it/e26ny6qb490d1.png?width=602&format=png&auto=webp&s=005fae12cea049f2cde8675cc454c590f54ca1c0
In 1901, the Italian Guglielmo Marconi reached his great achievement – a telegraph transmission from Europe across the Atlantic Ocean to America.
The German-Jewish Gustav Ludwig Hertz has already proved that electricity can pass through electromagnetic waves, those waves whose frequencies span across the spectrum from X-ray waves to UV waves, microwaves, and radio waves. Hertz conducted an experiment on the subject, got the frequency unit named after him, and has been able to transmit sounds not only through an electric cable (ie telegraph) but through the air (wireless telegraph). The last breakthrough was made by a Serbian genius named Nikola Tesla who demonstrated the system to the public in 1903.
A wireless telegraph does what a cable telegraph does – it transmits a message from point to point. What will make it a world changer is the human understanding that this technological ability can be used not only from a transmitting point to a receiving point, but from a transmitting point to dozens of receiving points at the same time and later tens of millions of receiving points. This is how the radio was born. The radio and the wireless telegraph are technically very similar and thus the radio was a natural continuation of the telegraph with the help of inventors and entrepreneurs (a famous story is of David Sarnoff, an American Jew who worked for Marconi's telegraph company that also sold radios and insisted despite his boss's refusal to broadcast the 1920 World Series, which became the largest and most successful mass broadcast of that time and helped for the public to get used to the radio. It is also worth noting that he already suggested in 1915 that the company change its branding to the ''Radio Corporation of America'' and sell music boxes to consumers, but the process took place only after General Electric bought the company).
Telegraph connected points; The radio connected audiences. Those who sat on an isolated farm, those who worked in a factory, those who relaxed in the living room of their homes, suddenly everyone had the ability to hear at the same time leaders’ speeches, classical music (and later rock and roll), they heard dictators, declarations of war and peace. Historical events were reported as quickly as possible on the evening news. The world with the radio will become more accessible to the masses.
In 1925, Scottish inventor John Logie Baird managed to produce a device that transmitted images of moving figures clearly and not just voices. In 1937 the RCA conducted its first television broadcast, while the first television receivers sold were physically large and took up space in the home living room like a piece of furniture and the viewing screen was small. During this period there were still no long broadcast hours and on certain days there were only special broadcasts. These broadcasts content was scarce and included mainly news and coverage of special events, such as various sports events.
World War II significantly slowed down the development of the television broadcasting industry. All technological effort was directed to the war effort. Only after the war did the industry begin to gather momentum again. Starting in 1947, a dramatic development can be seen in the amount and variety of commercial television broadcasts in the US and, along with it, in the rest of the developed world (together with a significant reduction in the price of the television compared to the pre-war world). A variety of comedy, drama and thriller programs aired alongside editions of news, entertainment, and other leisure programs. The American people began to buy televisions in droves, and this only encouraged the industry to invest in more reliable models and more continuous broadcasts.

That didn’t age well “drizzy”

After deciding the other month the wall of my Office needed jazzing up, I finally got my C.D. Feirense badge today to bring my save history map up to date. Pride of place on the wall right next to my Galway United shirt - the save I'll be taking from game to game forever now.
Several saves are missing because there just wasn't the space to fit them into the map. I am especially sorry to my historic 12/13 Vauxhall Motors save. Wish I'd had this idea years ago because I wouldn't have 1) had so many Tranmere Rovers saves 2) had so many North-West saves and 3) had so many English saves.
Definitely helped show my western and central Europe bias though (I'd always been unofficially trying to do the Big 5 Leagues over time). Need to branch out in future saves and try and get some further-flung European saves going.