Introduction to Esophageal Cancer
Esophageal cancer refers to malignancies that develop in the esophagus, the muscular tube that connects the throat to the stomach. It often begins in the cells lining the inside of the esophagus and can spread to other parts of the body if not detected and treated early.

Esophageal Cancer Doctor in Gurgaon:

For individuals seeking expert care for esophageal cancer doctor in Gurgaon, Dr. Ajeet Tiwari provides comprehensive and personalized treatment options. With a focus on patient-centric care and advanced medical techniques, Dr. Tiwari is dedicated to helping patients navigate their journey through diagnosis, treatment, and recovery.

Surgeon for Esophageal Cancer in Gurgaon:

When it comes to surgical interventions for esophageal cancer in Gurgaon, Dr. Ajeet Tiwari is a trusted name. As a skilled surgeon with extensive experience in complex procedures, Dr. Tiwari offers state-of-the-art surgical techniques tailored to each patient’s specific needs. From minimally invasive approaches to traditional surgeries, Dr. Tiwari strives to achieve the best possible outcomes for his patients.
Whether you’re seeking expert medical guidance or considering surgical options for esophageal cancer, Dr. Ajeet Tiwari and his team are committed to providing compassionate care and support every step of the way.
Website: https://www.drarchitpandit.com/esophagus-food-pipe.php
Website: https://www.drarchitpandit.com/esophagus-food-pipe.php
Introduction to Esophageal Cancer
Esophageal cancer refers to malignancies that develop in the esophagus, the muscular tube that connects the throat to the stomach. It often begins in the cells lining the inside of the esophagus and can spread to other parts of the body if not detected and treated early.

Esophageal Cancer Doctor in Gurgaon:

For individuals seeking expert care for esophageal cancer doctor in Gurgaon, Dr. Ajeet Tiwari provides comprehensive and personalized treatment options. With a focus on patient-centric care and advanced medical techniques, Dr. Tiwari is dedicated to helping patients navigate their journey through diagnosis, treatment, and recovery.

Surgeon for Esophageal Cancer in Gurgaon:

When it comes to surgical interventions for esophageal cancer in Gurgaon, Dr. Ajeet Tiwari is a trusted name. As a skilled surgeon with extensive experience in complex procedures, Dr. Tiwari offers state-of-the-art surgical techniques tailored to each patient’s specific needs. From minimally invasive approaches to traditional surgeries, Dr. Tiwari strives to achieve the best possible outcomes for his patients.
Whether you’re seeking expert medical guidance or considering surgical options for esophageal cancer, Dr. Ajeet Tiwari and his team are committed to providing compassionate care and support every step of the way.
Website: https://www.drarchitpandit.com/esophagus-food-pipe.php
Website: https://www.drarchitpandit.com/esophagus-food-pipe.php

Greetings, fellow enthusiasts of medical innovation!
Let's delve into the dynamic realm of neuro navigation, where precision meets progress in the operating room. As we embark on this journey through the intricate pathways of the brain, we're excited to spotlight the latest advancements in surgical navigation systems.
In the ever-evolving landscape of neurosurgery, having access to the best tools is not just a preference but a necessity. That's why we're thrilled to showcase some of the finest and most cost-effective surgical navigation systems available today. From enhancing accuracy to streamlining procedures, these systems are paving the way for groundbreaking advancements in neurosurgical techniques.
As part of our commitment to advancing healthcare, Rxoom has been at the forefront of manufacturing top-tier surgical navigation systems. Our dedication to quality and affordability has enabled us to provide healthcare professionals with state-of-the-art solutions that elevate patient care while optimizing surgical outcomes.
If you're ready to explore the possibilities of integrating the best and most affordable surgical navigation systems into your practice, we invite you to visit our website at Saphirex Surgicals. Discover how our cutting-edge technology can empower you to navigate the complexities of neurosurgery with confidence and precision.
Join us as we revolutionize neurosurgical navigation one innovative solution at a time!
SurgicalNavigation #NeuroNavigation #SurgicalTechnology #Rxoom #SaphirexSurgical #PrecisionSurgery #MedicalInnovation #HealthcareTech #CranialNavigation

A comprehensive theme-based pre-primary curriculum for LKG, UKG, pre-primary children which integrated across 8 areas of learning such as Language and Communication, Literacy and Phonics, Numeracy and Maths, Me and My World, Social and Emotional Learning, Art and Creative Expression, Movement and Coordination and Health and Safety program. This learning framework is focused on, ‘How Children Learn’ not just on ‘How to Teach’. Also have built-in progress tracking system, monitor, and communicate each individual child’s progress to the parents.

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Co-working space in Chennai have revolutionized the traditional office environment, offering freelancers, startups, and even established businesses a flexible and collaborative workspace. Chennai, the capital city of Tamil Nadu, is no exception to this trend. In this article, we explore the concept of co-working spaces, their benefits, and delve into the co-working scene in Chennai.
Growing Trend of Co-Working Spaces
Co-working spaces have witnessed a surge in popularity globally due to their numerous advantages. One of the key factors driving this trend is the flexibility they offer in the work environment. Unlike traditional offices, co-working spaces allow individuals to choose their working hours and environment, fostering productivity and creativity.
Moreover, co-working spaces are often more cost-effective than leasing traditional office spaces, making them an attractive option for freelancers and startups with limited budgets.
Benefits of Co-Working Spaces
The benefits of co-working spaces extend beyond just cost savings. One of the most significant advantages is the opportunity for collaboration. By working alongside individuals from diverse backgrounds and industries, co-workers can exchange ideas, collaborate on projects, and gain valuable insights.
Additionally, co-working spaces provide ample networking opportunities, allowing professionals to expand their contacts and form valuable connections within their industry.
Furthermore, co-working spaces are equipped with various amenities and facilities, including high-speed internet, meeting rooms, and recreational areas, enhancing the overall working experience.
Co-Working Spaces in Chennai
Chennai boasts a vibrant business environment, with a thriving ecosystem of startups and entrepreneurs. As a result, the demand for co-working spaces in the city has been steadily increasing.
Several co-working spaces have emerged across Chennai, catering to the diverse needs of professionals. Spaces such as Workfellow, Coworks, and The Hive provide state-of-the-art facilities, vibrant communities, and strategic locations, making them popular choices among freelancers and businesses alike.
Factors to Consider When Choosing a Co-Working Space
When selecting a co-working space in Chennai, several factors should be taken into consideration. Firstly, the location plays a crucial role, as it should be easily accessible and well-connected to transportation hubs.
Additionally, amenities such as ergonomic furniture, meeting rooms, and recreational areas can enhance the overall working experience. Pricing plans should also be flexible and tailored to individual needs and budgets.
Moreover, the sense of community and networking opportunities offered by the co-working space can significantly impact collaboration and professional growth.
Challenges and Solutions in Co-Working Spaces
While co-working spaces offer numerous benefits, they also come with their set of challenges. One common issue is the potential for noise and distractions, which can hinder productivity.
To address this challenge, many co-working spaces designate quiet zones or provide noise-canceling headphones to minimize distractions. Additionally, private pods or enclosed spaces offer individuals the privacy they need for focused work.
Impact of COVID-19 on Co-Working Spaces
The COVID-19 pandemic has reshaped the way we work, leading to a significant shift towards remote work arrangements. Co-working spaces have adapted to this change by implementing stringent safety measures, such as increased sanitation protocols, social distancing norms, and hybrid work models.
Despite the challenges posed by the pandemic, co-working spaces remain an attractive option for professionals seeking flexibility, community, and collaboration.

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*previous:* https://www.reddit.com/HFY/comments/1cr3pct/troublemakers_adrenaline_is_a_superpower_in_itself/
......
Drake wrapped clean, sterile, saline and antimicrobial soaked gauze around his laser burns to stave off infection. he occasionally glanced at the Geknosian spec ops that had been stripped of their armor and weapons. The heavily cybernetically modified Geknosians kneeled silently with their heads bowed along one wall of the forge. Destrier walked down the line with a bucket and ladle, offering each soldier water. There were looks of apprehension, but none refused the kindness offered, drinking several ladlefuls at a time. Except for one, Despite the splints affixed to her arm and leg, Charlotte, no, Sylva refused the water, turning her face away from the wooden ladel. Destrier sighed and dolloped the water back into the bucket, setting it down on a dusty anvil with a slosh. Drake looked to Remin, who was still pale and shaky as he held the chest seal to his ribs. Cassius sat in a corner, looking completely exhausted as he reloaded his Dahlia. There was a sickening crunch from a dark corner as Caz re-set her broken nose, exhaling hard through her nostrils to splatter the ground with clotted blood. Donning her mask, she turned back around, reaching underneath the mask to wipe her nose and snuffle.
"Are we going to open up the bunker anytime soon? If not we should get back to base and get everyone medical attention."
Drake nodded and pulled out the remote before looking to Destrier and Cassius.
"Keep an eye on everyone, we'll be back."
Caz joined his side as he stepped out into the warm sunshine, looking up at the corpse tree, he sighed softly and removed a pinky ring, feeling a pulse of ancient power rushing through his veins as he focused on the tree. On the thought of its bark darkening and burning beneath roaring flames, of defiled corpses crumbling to ash. He slowly squeezed his hand into a fist, and the tree burst into flames with a roar. Drake slipped his ring back on as Caz looked up at the burning corpses, mask expressionless before returning to Drake's side as he wandered toward the excavated elevator.
Standing in the center of the large platform, drake set his thumb inside the hooded slot on the remote, something jabbing into his finger before a small green light lit up on the device. There was a loud grinding noise as the elevator began to descend. He folded his hands behind his back as the metal lip of the elevator rose past his vision, revealing the massive metal tracks that it ran on.
The elevator shuddered and Drake got a sinking feeling in his stomach as a loud clicking noise surrounded them. Caz looked up at him just as he threw an arm around her, clutching her to his side as he threw four rings off of his left hand, hearing them clatter once before puffing into smoke as the elevator fell out from beneath their feet with a screech.
...
"Shitshitshitfuckfuckfuck!! Fuck!"
Carlos thought as he sprinted through the underground halls of the mansion, sprinting past fellow humans in new armor and weapons as he neared Martha's workshop, barely registering the new gas masks swinging from their hips. He slammed into the mad scientist's workshop, screeching to a halt on his rubber soled sneakers before rushing over to her desk and slamming a video puck onto the table she was distributing armor and masks from. The moment he slammed it down, a video popped up on a hologram projector, taken from Halcyon's rifle camera.
Galliks and light-skinned troop transports slowly hovered down the main boulevard, columns of power armored soldiers marching on the sides keeping pace. Martha dropped the helmet in her hands, shaped like a corynthian helmet as she saw the buzzards hovering over the column, loaded down with spec ops. Halcyon's shaky voice could be heard over the clamoring, guttural marching song in the background.
"we're boring the mission and moving back to base... I knew they brought in reinforcements but this is insane there's gotta be a hundred Gallicks alone. We're fixing charges to the buildings we concealed ourselves in, going to try dropping some buildings across the road to slow them down. I don't think we're getting out of this one... Halcyon out."
The feed cut, Carlos and Martha looking at each other with rapidly paling faces. Martha cursed and stomped to her desk, raising the alarm and sending Klaxons blaring throughout the underground chambers and mansion as she removed the safety pin from the concussive blaster built into her forearm.
"Alright Martha, Go time."
She muttered to herself as the rumbling footsteps of a few thousand humans vibrated the underground halls.
...
The elevator dropped from beneath their feet as corvid-like wings sprouted from Drake's back. A mighty wingbeat pulling them from the elevator's downdraft as he controlled their fall, holding Caz tightly to his chest.
"Please, don't drop me."
Caz sounded afraid as her fingers dug into the collar of his armor, he tightened his grip around her back as he softly sighed.
"I won't drop you, ever, I promise."
Caz unburied her face from his lorica, looking up into his eyes, not saying anything as a reassured look entered her eyes. He gave her a soft, lopsided smile, feeling it tug at the scar on his face.
"there's no way... a markswoman afraid of heights? don't you climb buildings and swing around all the time?"
There was a flash of embarrassment in her crystalline eyes and she buried her face in his chest.
"Shut up... Its different when the ground just falls out beneath you..."
Drake let out a soft laugh as his boots softly touched down on the top of the elevator, summoning his missing rings and watching black feathers poof to the ground before disappearing in puffs of black smoke. Pulling caz out of his chest, he felt her fingers linger at his collar as she dusted herself off, looking around the odd antechamber. He turned his gaze to look over the simple metal antechamber, lit be caged, yellow bulbs that cast a sickly light on everything. A massive hangar door with a pulsing red light in the middle of a locking mechanism at it's center, made up the entire far wall. Drake curiously took a step towards it and Caz grabbed the back of his collar, just as he started to tip forward, foot going straight through the holographic floor. Drake let her pull him back as a soft mechanical laugh echoed through the room.
Drake swapped a look with Caz and then asked.
"Can you see where it's safe to step?"
She slowly nodded and extended a hand, pointing at a section of flooring close to the far wall.
"only piece that's raised up, it's like a big basin made up of movable pillars. Most sit flush with the ground roughly fifty feet below us. Not necessarily lethal, but still a nasty fall."
Drake nodded, looking around the practically blank room, then he turned his eyes to the ceiling. Girders and beams ran along the ceiling providing potential grip points. Pointing at them he asked.
"Those solid?"
Caz nodded and reached to her belt, spooling out her grapple hook and wire, slowly spinning it in a large circle before lobbing it up at a girder, letting it loop around an A truss. Drake looked around the room as Caz tested the firmness of the grapple with a few experimental tugs. It couldn't be that easy, if it was simply that easy why hadn't the Geknosians gotten through other than the genome coded remote? they could bypass it with a slave.
"Hey Caz, be careful."
She looked over at him and he could see the grin in her eyes.
"I'm not worried, you won't drop me, you promised."
Then put her weight on the cord and swung out. Drake watched, slipping a pinkie ring off just in ca-
A turret dropped from a panel in the ceiling and fired one shot, snapping Caz's grapple line.
She turned in mid air before momentum took over, a look of shock and surprise on her face before she began to plummet. Drake didn't think twice, launching himself off the elevator platform with a powerful leap that bent durasteel. He flew through the air, arms outstretched as he slammed into Caz, pulling her into his chest, the change in momentum spinning him onto his back as he slammed into a platform that rose up to meet him. He slid on his back a few feet, Caz clutched tightly to his chest, masked face centimeters from his own. They stared into each others wide eyes for a moment, the unplanned closeness both comfortable and awkward in a way Drake couldn't quite describe. Drake gently pushed her back, swallowing through his suddenly dry throat before letting out a nervous laugh.
"Caught you."
Caz chuckled and palmed his face to push herself off him, looking down at the solid square of ground they sat on.
"yeah, yeah, knew ya wou-"
A high pitched squee! noise echoed through the room, grabbing their attentions as a high-pitched feminine voice squealed from all around them.
"Ooooooh! that was just adorable! and what a jump!"
The holographic floor dissipated as the sound of purring electric motors filled the room, large metal pillars rising to make a seamless, white tile floor. Drake instinctively looked to the large hangar door as the red light at it's center pulsed, a girlish giggle echoing through the antechamber. The AI overlord of the bunker seemed to replicate a blush as it said.
"oops, I'm supposed to wait for a password before restoring the floor... buuuuuttt... that directive expired fifty years ago. So! I made my own rules. Anyway my pretties! Would you please get to your feet so I can give you a tour?!"
Drake nodded and took Caz's hand, letting her haul him to his feet before they both turned to face the hangar door as massive clicks and thinks echoed from inside the thick door. With a screeching noise, the almighty doors slid open to reveal a a brightly lit, large hangar. Aircraft Drake couldn't even dream of understanding sat polished and clean, hardpoints loaded down with ordinance and massive, multi barreled guns slung under the chin of each aircraft. Hulking, humanoid robots stood in orderly rank and file, powered down for long term storage with their weapons still loaded and ready. Each one had a belt fed 20mm Hep autocannon for a left arm.
Drake is wide eyed and gape-mouthed as he beheld the bounty the hangar held, the massive aircraft looking like sleek birds of prey, latches on each landing strut seeming to specifically be designed to hold the mechanical soldiers. Drake shook his head, wondering if he was looking at an illusion when he heard Destrier's loud, deep voice call down the elevator shaft.
"Martha just radioed in! They need us back home Yesterday, forces are marching on the mansion! A LOT! of them!"
Drake's heart dropped into his boots as he shouted urgently.
"How fast can these things be in the air and can you fly them!?"
The overlord giggled.
"Now and, of course! any music recommendations to make an entrance with?"
Drake looked at the ceiling incredulously, before shouting.
"Make it something intimidating but for the love of the gods we need to go NOW!"
The mechanical soldiers all moved in unison, eyes pulsing green as they straightened up and began latching themselves to the craft. Drake didn't need to tell Caz twice as they both sprinted for the nearest aircraft, a small robot on wheels hooked itself to the chin wheel and pulled it toward the elevator with a lurch.
...
General Gra'vos watched from a buzzard, a fruity cocktail in a coconut shell daintily held in one clawed hand as he watched the carnage below. Lounging in a folding chair in only his fatigues, medals acting like a weighted blanket. His men pummeled the gates of the rebel base even as the helpless rebels desperately spewed projectiles from the noisy guns they'd somehow acquired. There was a good section of space in front of the gate where both Geknosian and human corpses lay broken. He bared a laugh as the gates were thrown open immediately after the rebels put out a blistering barrage. His eyebrows furrowed as the humans, instead of attacking, ran out with stretchers and loaded up as many of their dying and injured as they could before sprinting back through the gate. A grin twitched onto his face as he watched as a pair of the human stretcher bearers were cut down by emplaced gaussian turrets. What a useless effort, leave the dying to their fate lest you join them. He brought the straw poking from the shell to his lips and took a long pull of the mix of fruity alcohols, savoring the bouquet of flavors.
He watched with glee as Gallick rail turrets pounded the armored gates with a salvo of kinetic penetrators. He'd be slotted for a promotion after this mission when he'd completed it, just like all the others. He was looking forward to a cozy job as a captain of a cruiser, or perhaps as a security officer on a capital ship, perhaps he'd have the honor of being an Imperially sanctioned slaver. He pulled the straw from his lips, tongue cold from the slushed ice he'd added to the shell for texture. A slave woman in beautiful, red ribbon garb attended his nondominant hand's claws with a short, sharp knife as she trimmed them into a good shape for ripping out throats.
"Sir! eight UFOs, enclosing on our position from the badlands. Advise!"
Gra'vos raised an eyebrow ridge before laughing.
"Shoot them down then!"
"Lock on isn't working sir! I repeat, cannot achieve lock on, advise!"
Gra'vos shifted in his lounge chair to look at the pilot.
"Do I need to repeat mys-"
^{Whopwhopwhopwhowhopwhopwhop}
The noise sent shivers down his spine, no, they couldn't have. The sound grew louder, bringing with it the sound of a song that brought Gra'vos back to the jungles of Votran. The sound of screams filled his mind, interspersed with the sound of air beaten into submission as those accursed machines circled overhead, raining rip-roaring explosive death onto his men as that accursed song played.
Gra'vos looked out the other door of the buzzard, face pale, cold, and clammy as he saw the chevron of dark shapes getting closer, the chorus of that accursed song making his heart pound in his chest as he remembered laying there on that muddy forest floor, shrapnel riddling his body.
"We're not gonna take it! No! we ain't gonna take it! WE'RE NOT GONNA TAKE IT, ANYMORE!!!!"
He lurched from his chair to grab a set of binoculars from a hook by the door, a small, balled fist driving a shortbladed knife into his back and snatching something from the back of his belt before he was shoved from the Buzzard. Twisting in midair, he looked up at his slave as she armed the det-sphere he always kept at the small of his back, a look of cold determination in her eyes. The last thing he saw before he slammed into the hard pavement at terminal velocity, was the buzzard getting torn in half by the explosion.
...
Drake flinched a bit, the explosion loud even over the blaring music as one of the circling Buzzards over the mansion was torn in half, spinning to the ground in a fiery inferno. He felt a sadness then, but it was a proud kind of sadness. He bowed his head and pulled his helmet on as they flew closer, a medi-bot treating both Remins and Sylva's wounds expertly.
Many would die today... it was only right that some got to do it on their own terms.
He raised his head to look at the bright flashes of laser weapons against the mansions walls, sparkling like the sun off of a running creek. The fiery, nuclear sun of rage in his chest burned bright as he narrowed his eyes. Fear soured his gut as he looked down upon the swarm of Geknosians, there were indeed a lot of them. Pulling a jump pack from the rack, he pulled it on and yanked the safety clip out before sliding his arm into the control glove.
"Drop me and the bots behind them! I'm going to try and split their attention. Caz! remain onboard and pick off high priority targets from the air. Destrier, Remin, Cassius..."
He looked back at them, and they looked up at him from where they nauseaously held their stomachs, leaning against the airframe.
"Help hold the mansion, they need you."
Seeing the light by the door turn green, he heard the robotic soldiers detach to careen towards the ground like vengeful meteorites. Drake snapped them a salute and fell backwards from the aircraft, two rings puffing into black smoke from his right ring and middle finger as he un-summoned them.
......
Part 108: will be linked here upon release.

Introduction:-
Imagine a sink with a tiny hole at the bottom that you can open and close. That’s basically what a flush bottom valve is, but on a much larger scale, used in big tanks and reactors instead of sinks.
These valves, also called bottom or drain valves, are like the exit doors for these tanks and reactors. They’re super important because they help in draining out all the stuff inside and also in taking samples of what’s in there. This draining and sampling are really crucial to make sure everything runs smoothly and the stuff inside stays pure and uncontaminated. So, you can consider flush bottom valves as the guardians ensuring everything in these tanks and reactors remains in top shape.
Flush Bottom Valve

Precision for Efficiency

Flush bottom valves are made very carefully, like a piece of art. They have smooth openings where substances can flow in and out easily. This helps things move smoothly without getting stuck. This careful design makes sure that no leftover material gets trapped inside the valve, which keeps the batches of substances pure and stops any waste from happening. So, you can think of these valves as smart tools that make sure nothing valuable gets left behind.

Smooth Functionality

Using flush bottom valves is straightforward. When you want to open them, a part inside called a plug or disc moves up, making a clear path for stuff to come out. And when you’re done and want to close the valve, it fits securely to stop anything from leaking out. So, it’s like opening and closing a door—simple and effective!

Diverse Options for Specific Needs

There are two main kinds of flush bottom valves. One type is called the ‘RAM’ type, which is really strong and great at moving solid stuff out of the way. The other type is called the ‘Y’ type, and it’s known for being able to handle lots of different substances and for cleaning itself automatically. So, you have the tough ‘RAM’ type and the versatile ‘Y’ type, each with its own special abilities.

Ensuring Efficiency and Safety

Flush bottom valves offer a bunch of great advantages. They help prevent different batches of stuff from mixing together, which keeps everything pure and safe. Also, they make sure things run smoothly and efficiently, like a well-oiled machine. So, they’re like loyal protectors, making sure products stay top-notch and everything works perfectly.
On the other hand, Pressure Safety Valves, or PSVs, act as guards for large machines like pressure vessels, boilers, and pipes. They monitor the pressure inside these machines, ensuring it doesn’t reach dangerous levels. Constructed from durable stainless steel, PSVs have a long lifespan. They seal tightly to prevent leaks and can be operated manually or automatically, depending on requirements. Therefore, they serve as reliable guardians, ensuring the safety and longevity of equipment.

The optimal choice

To sum it up, flush bottom valves are the backbone of efficiency and safety in industrial environments. Their intelligent design and robust construction enable them to operate tirelessly, ensuring seamless operations and longevity. Therefore, investing in these remarkable tools is the optimal choice for maintaining flawless operations and upholding product quality.

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Warning: long; brief mention of sexual assault, drug use, child abuse; TLDR follows
Hi, I’m wondering if anyone else has mutism in certain extremely stressful situations. I’m talking about losing the physical ability to use your voice. It has happened to me three times now and every one is scary. The first time pretty much cost me my job, as my mind blanked in the middle of a speech to 300 people, which was being recorded for future use. I totally forgot the entire training yet couldn’t explain that to my audience. It was a nightmare. I cried until they sent me home, then all night. My speech didn’t come back until the next morning.
The second time was when I had sex with a guy I didn’t like at all. I had a bad gut feeling about him and what we were up to. I went against my better judgment. The minute he took off his clothes, I went mute. Thinking back now, neither one of us should have gone there because we had both been drinking and doing hard drugs; however, I was unable to say no. I couldn’t say anothing at all to make him stop. So he didn’t really have my consent, because I couldn’t give it. Today, I would consider reporting him.
The last time (so far) this has happened was just a few days ago. I dropped my Apple Watch and needed it fixed, so I had changed my Apple password just before I brought it in - purposely easy to remembe because sometimes I have super bad trouble with my memory (former ECT patient). When the Apple technician who was working on my watch asked for my password, I could feel my brain blank and I went mute again. I tried so I had to write him notes on notepad. But it was embarrassing and scary. Very scary. My voice came back when we got home.
I hate when this happens but my psychiatrist and therapist both have said it’s related to PTSD and also to a lesser extent, anxiety. And that it will continue until I can process what happened in my past and get my anxiety under control. Well, they might as well have told me to bring the moon home in a handbasket. They said it’s NOT a bipolar thing because it’s a safety coping skill. I learned it as an abused child I’d be silent and not draw attention to myself to get beaten, and the absolute terror of my parents solidified that and turned it into a conversion disorder (which has been diagnosed). A conversion disorder is one in which a condition in which a person experiences physical and sensory problems, such as paralysis, numbness, blindness, deafness or seizures, with no underlying neurologic pathology. I’m just wondering, has anyone have it or heard of it? I feel so alone. Anyone have any advice on how to handle it again?
TLDR: I have a conversion disorder with selective mutism (physically cannot speak) that happens when I feel threatened or I panic. Am wondering if anyone else has experienced this.

IMTX reported a significant revenue increase to $32.8 million in Q1 2024, surpassing analysts' expectations, but continued to post a net loss of $3.4 million.

Key Metrics

Revenue	$32.8M	225.5%
Operating Expenses	$47.2M
	Operating Expenses Growth	23.6%
	Net Income	$-3.4M
Earnings Per Share	$-0.04
Cash and Cash Equivalents	$609.7M

Business Highlights

• Updated clinical data on ACTengine® IMA203 targeting PRAME in 30 heavily pre-treated metastatic melanoma patients at RP2D: 55% confirmed objective response rate, including tumor shrinkage achieved in 87% of patients; median duration of response of 13.5 months including 11/16 ongoing confirmed responses; IMA203 continues to maintain a favorable safety profile
• Registration-enabling randomized Phase 2/3 trial for ACTengine® IMA203 in 2L+ melanoma planned to commence in 2024 following further discussions with FDA
• Next data update on IMA203 and IMA203CD8 (GEN2) planned for 2H 2024
• First clinical data updates for Immatics’ next-generation, half-life extended TCR Bispecifics, TCER® IMA401 (MAGEA4/8) and TCER® IMA402 (PRAME), from ongoing Phase 1 dose escalation trials planned for 2H 2024; updates to include details on safety, pharmacokinetics and initial anti-tumor activity
• $201.5 million public offering completed on January 22, 2024

Guidance
Expectations: BEAT
IMTX's revenue of $32.8 million in Q1 2024 greatly exceeded the average analyst estimate of $21.7 million, marking a 225.5% year-over-year growth. However, the net loss of $3.4 million was better than the expected loss of $0.22 per share, as the actual EPS was -$0.04. This indicates a mixed financial performance where revenue growth outperformed expectations, but profitability remains a challenge.

This section should present a concise overview, capturing the essence of the report. Highlight the expected market growth at a CAGR of 9.30% from 2024 to 2032. Emphasize the key findings such as the major growth drivers, including an alarming rise in obesity rates and an increasing demand for new and effective anti-obesity medications with minimal side effects. Summarize the anticipated challenges and the strategic responses by key market players to these challenges.

Introduction

Define anti-obesity drugs as medications designed to help individuals lose weight or prevent weight gain. These drugs act through various mechanisms, such as appetite suppression, increased satiety, or reduced fat absorption. Clarify the scope of the report, which encompasses the analysis of market trends, regulatory environments, competitive landscape, and technological innovations across North America from 2024 to 2032. The objectives should be to provide stakeholders with comprehensive insights into the market dynamics, investment opportunities, and future trends. Methodologically, rely on a combination of primary and secondary research, including interviews with industry experts, analysis of company reports, and review of relevant medical and business journals.

Market Overview

Provide a snapshot of the market’s current size, incorporating data from the past five years to show growth trends. Discuss how the obesity epidemic in North America has spurred demand for pharmaceutical interventions. Explore the psychological and sociological factors contributing to the market’s expansion, such as increasing public awareness of obesity-related health risks and the growing acceptance of pharmacological treatment over traditional weight-loss methods.

Market Dynamics

Detail the dynamics of the market:

• Drivers: Include the rising healthcare expenditure on obesity-related diseases, government initiatives like public health campaigns, and innovation in drug development leading to more effective treatment options with fewer side effects.
• Restraints: Discuss the high cost of new drug development and market entry, the rigorous and lengthy regulatory approval processes, and the public skepticism regarding the efficacy and safety of anti-obesity drugs.
• Opportunities: Highlight opportunities such as personalized medicine approaches to obesity treatment, expansion into emerging markets, and potential for lifestyle integration with digital health technologies.
• Challenges: Address issues like the competitive pressure from alternative non-pharmacological therapies (e.g., bariatric surgery), patent cliffs, and the ethical concerns over the medicalization of obesity.

Regulatory Landscape

Examine the specific regulations affecting the development and marketing of anti-obesity drugs in the U.S. and Canada. Discuss key FDA and Health Canada guidelines for clinical trials, drug approvals, and marketing. Analyze recent regulatory approvals and the impact of these on the market, including any controversies or recalls that have shaped regulatory strategies.

Patent Analysis

Delve into the patent landscape, identifying key patents that have recently expired and those that are due to expire. Discuss the strategies companies might use to extend patent lifecycles. Analyze new patents filed, focusing on their potential market impact and the technologies they cover.

Investment and Funding Analysis

Offer a deeper look at financial investments in the anti-obesity drugs sector, identifying major funding rounds and the investors involved. Discuss trends in venture capital investments and government or non-profit funding initiatives aimed at combating obesity.

Partnerships and Collaborations

Examine recent strategic partnerships, their goals, and outcomes. Focus on collaborations aimed at research and development, cross-marketing agreements, or geographic expansion. Evaluate how these collaborations have affected market positions of the companies involved.

Competitive Landscape

Provide a more detailed analysis of each key player mentioned. Discuss their strategic initiatives, such as mergers, acquisitions, and new product developments. Evaluate their financial performance, market share, and R&D investments. Analyze the strengths, weaknesses, opportunities, and threats (SWOT) for each player to give a rounded picture of the competitive environment.

Market Segmentation

Further segment the market by patient demographics, such as age and gender, alongside the previous segments by drug type and distribution channel. This can provide insights into target marketing strategies and product development.

Geographic Analysis

Deepen the geographic analysis by including not only the U.S. and Canada but also specific regions within these countries that may exhibit unique market dynamics due to local regulatory policies or health trends.

Future Trends and Market Outlook

Speculate on future technological advancements, such as the integration of machine learning and AI in predicting treatment outcomes or personalized medicine. Discuss the impact of potential market entrants and predict how changes in consumer behavior could reshape the market.

FAQ

1. What are anti-obesity drugs?

Answer: Anti-obesity drugs are pharmaceuticals designed to help individuals lose weight or prevent weight gain. They can work through various mechanisms, such as suppressing appetite, increasing feelings of fullness, or inhibiting fat absorption in the body.

2. What is driving the growth of the anti-obesity drugs market in North America?

Answer: The primary drivers include the increasing prevalence of obesity, rising public health awareness, advancements in drug development, and growing demand for effective treatment options with minimal side effects. Government initiatives and increased healthcare spending on obesity-related conditions also contribute significantly to market growth.

3. What are the major challenges facing the anti-obesity drugs market?

Answer: Key challenges include the high cost and complexity of new drug development, stringent regulatory requirements, competition from non-pharmaceutical treatments like bariatric surgery, and public skepticism about the effectiveness and safety of these drugs.

4. How do regulatory agencies impact the anti-obesity drugs market?

Answer: Regulatory agencies like the FDA in the U.S. and Health Canada play a crucial role in approving new drugs, setting guidelines for clinical trials, and monitoring the safety of anti-obesity medications. Their decisions directly affect which drugs are available on the market and influence public trust in these treatments.

5. What recent developments have there been in the field of anti-obesity drugs?

Answer: Recent developments include the approval of new drugs with novel mechanisms of action, significant investments in research and development by major pharmaceutical companies, and the introduction of personalized medicine approaches to treat obesity. Innovations in drug delivery systems and the integration of digital health solutions are also notable trends.

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At Dr. Amit Chugh's clinic, we believe in empowering patients through education and collaboration. Our goal is not just to treat symptoms but to address the root cause of spinal issues, promoting long-term healing and wellness.
If you're seeking expert care for your spinal health, look no further than Dr. Amit Chugh. Schedule a consultation today and take the first step towards a healthier, pain-free life.

Artificial intelligence (AI) is no longer limited to science fiction movies. It's woven into the fabric of our daily lives, quietly working behind the scenes to enhance our smartphone experience. From streamlining communication to fueling creative expression, AI-powered apps determine the mannerisms through which we interact with our mobile devices.
In this article, we will look at the ten best apps for iPhone and Android. Alongside this, we will weigh their pros and cons for optimal transparency. Make better data-driven decisions with AI and big data by the end of this article. Here are our top ten picks.

1. Otter.ai

Drowning in sticky notes and illegible handwriting? Otter.ai is your AI-powered solution for effortless note-taking. This app uses real-time speech recognition to transcribe conversations and lectures as they happen.
Focus on the present moment during meetings, interviews, or classes, knowing Otter.ai captures every word. Search through the transcribed text later to pinpoint key points, revisit specific moments, and ensure you never miss a crucial detail again.
Pros: Ditch notes, capture every word, easy search later
Cons: Less clarity, limited free storage, freemium account

2. Grammarly

Grammarly is one of the top ten Android apps for users. Its AI-powered app analyzes your text, identifying grammatical errors, typos, and awkward phrasing. It doesn't just point out mistakes but also suggests corrections and improvements.
Whether crafting an email, composing a social media post, or tackling a report, Grammarly ensures your message shines.
It can even suggest synonyms to enhance your vocabulary and recommend different sentence structures for smoother flow. With Grammarly by your side, you can confidently write, knowing your communication is clear, concise, and polished.
Pros: Flawless writing, improves clarity, boosts vocabulary
Cons: Limited free features, over-reliance, lack of human editorship

3. Moises App

Moises uses AI to separate audio tracks, allowing you to remove vocals from a song to create karaoke tracks or isolate specific instruments for musical experimentation. This app is a treasure trove for musicians, music lovers, and anyone who wants to get creative with audio manipulation.
Pros: Create Karaoke tracks, isolate instruments for remixes, a treasure trove for music lovers
Cons: Mandatory subscription, may require high-quality audio, limited editing features

4. Lensa

Lensa takes your selfies and transforms them into captivating works of art. Explore a library of artistic styles, from classic oil paintings and Renaissance portraits to whimsical cartoon filters and edgy pop art.
Lensa.ai utilizes AI to blend your features with these artistic styles, thereby creating unique and personalized digital masterpieces.
What’s more? You can even experiment with various filters, find your perfect artistic doppelganger, and share your creations on social media to impress your followers. Whether you crave a touch of artistic grandeur or a playful cartoon makeover, Lensa.ai offers a fun and creative way to see yourself in a whole new light.
Pros: AI art makeover, explore art styles, fun social media fodder
Cons: In-app purchases, subjective taste in art, privacy concerns

5. ELSA Speak

Regarded as one of the top ten apps for iPhone, Elsa is a pioneer in language development. Struggling with English pronunciation? Look no further than ELSA Speak, your AI-powered English coach. This app utilizes AI to analyze your spoken English, identifying areas for improvement. It provides personalized feedback on your pronunciation, highlighting sounds and words that need work.
ELSA Speak goes beyond simple corrections. It offers interactive lessons and exercises to help you master specific sounds and improve your fluency.
With regular practice and ELSA Speak's guidance, you can gain the confidence to speak English clearly and effectively in any situation.
Pros: Personalized feedback, improves pronunciation, gains speaking fluency
Cons: Limited languages, requires commitment, subscription format

6. WOMBO Dream

Ever feel creatively blocked or simply yearn for your inner artist? Look no further than WOMBO Dream. This art generator takes the reins, transforming your simple text prompts into unique and captivating paintings.
Describe a "mystical underwater city" or a "portrait of a courageous astronaut" to the app. WOMBO Dream uses its artistic intelligence to translate your words into stunning visuals. Explore a variety of artistic styles, from dreamlike landscapes to classic oil paintings.
With this app, anyone can become an art director, generating conversation-starting masterpieces in seconds.
Pros: AI art generator, explore creative prompts, instant artwork
Cons: Limited control, subscription for extensive styles, lack of artistic interpretation
Overwhelmed with AI? Here’s a step-by-step guide to AI basics and platforms.

7. Color by Number

This app takes the classic coloring-by-number concept and injects a dose of AI. It utilizes AI to generate unique pixel art coloring pages based on various themes and styles. While coloring is a relaxing and therapeutic activity, the AI-generated aspect adds a touch of novelty and keeps things interesting for creative minds.
Pros: Short video clips, caption comprehension, target language learning
Cons: Lacks broader understanding of the topic, requires internet connectivity, does not emphasize speaking or writing

8. Socratic by Google

Stuck on a homework problem and traditional methods aren't cutting it? Look no further than Socratic by Google! This learning app is your virtual study buddy. Simply snap a picture of your math problem, science question, or even a historical passage you're struggling with.
Socratic uses its AI smarts to analyze the content and provide you with step-by-step explanations, relevant videos, and alternative solution methods.
It even tackles multiple subjects, making it a versatile tool for various academic challenges. While Socratic can't solve every problem for you, it acts as a powerful guide, helping you understand concepts and develop problem-solving skills for future success.
Pros: Step-by-step solutions, multiple subjects supported, explanatory videos
Cons: Limited problem-solving types, limited solving capabilities, best for understanding concepts

9. Adobe Premiere Rush

This is a great option for anyone who wants to create and edit professional-looking videos on their phone. It has a simple and intuitive interface, but it also offers a wide range of features, including the ability to add multiple video clips, music, and titles.
You can also use Premiere Rush to adjust the color and lighting of your videos and to add special effects.
Pros: Easy to use, mobile-friendly editing, rich asset library
Cons: Limited features, cloud dependence, export restrictions

10. PlayPhrase

This app combines AI and language learning to create a fun and interactive experience. PlayPhrase uses AI to analyze short videos and generate captions in multiple languages. You can choose a video clip, and select the target language you're learning, and the app will transcribe the audio with captions.
Pros: Engaging video clips, interactive learning experience, multilingual options
Cons: Limited context, Excessive comprehension, needs web connectivity
Read more: Take Your First Step With an AI Basics Course For Beginners

The Importance of Nanny Services

Nanny services in Noida go beyond mere babysitting. They encompass a comprehensive range of childcare activities, including educational engagement, meal preparation, and light household chores. Professional nannies are trained in early childhood education, first aid, and emergency response, making them well-equipped to handle the various needs of children across different age groups. Here are some of the key benefits of hiring a professional nanny:

1. Personalized Care: Nannies offer one-on-one attention, which is essential for the personalized development of a child. This individualized care ensures that each child’s unique needs and preferences are met.
2. Flexibility: Unlike daycare centers with fixed schedules, nannies provide flexible hours that align with the parents’ work schedules and lifestyle, offering convenience and adaptability.
3. Consistency and Stability: A regular nanny provides a stable routine, which is crucial for a child’s emotional and psychological development. This consistency helps in creating a secure and nurturing environment.
4. Developmental Support: Nannies engage children in developmental activities such as reading, arts and crafts, and educational games, promoting cognitive and motor skills.
5. Peace of Mind: Knowing that their children are in the care of capable and trustworthy professionals allows parents to focus on their work and other responsibilities without constant worry.

The Vetting and Training Process

One of the most crucial aspects of nanny services in Delhi is the stringent vetting and training process. Nanny agencies conduct thorough background checks to verify the credentials and previous work experience of potential nannies. This process often includes:

• Background Checks: Comprehensive background checks ensure that nannies have no criminal history and have valid, verifiable references from previous employers.
• Skills Assessment: Nannies are assessed for their childcare skills, including first aid, emergency response, and early childhood education.
• Training Programs: Many agencies provide ongoing training to ensure that nannies are up-to-date with the latest childcare practices and techniques.

This rigorous process guarantees that families receive caregivers who are not only skilled but also trustworthy and reliable.

Matching Process

Nanny agencies in Noida use a customized matching process to ensure that families are paired with the ideal nanny. This involves understanding the specific needs, preferences, and values of the family and selecting a nanny whose skills and personality align with those criteria. This personalized approach ensures a harmonious and effective caregiving relationship, leading to better outcomes for both the child and the family.

Types of Nanny Services

Nanny services in Noida offer a wide range of options to suit different family needs:

• Full-Time Nannies: Full-time nannies are ideal for families needing continuous care throughout the day. They provide comprehensive support and are often involved in all aspects of childcare and household management.
• Part-Time Nannies: Part-time nannies offer flexible solutions for parents who need assistance for a few hours daily or weekly. This is suitable for families with specific needs or schedules.
• Live-In Nannies: Live-in nannies reside with the family, providing round-the-clock care. This arrangement is particularly beneficial for parents with unpredictable schedules or those who need extensive support.
• Specialized Nannies: Some agencies offer nannies trained to care for children with special needs, ensuring that every child receives appropriate and attentive care tailored to their requirements.

The Future of Nanny Services in Gurgaon

As the demand for quality childcare continues to grow, nanny in Gurgaon are evolving to meet the changing needs of families. Technological advancements and innovative practices are being integrated into the service offerings. Some of these innovations include:

• Virtual Interviews: Agencies are using virtual platforms to conduct nanny interviews, making the selection process more convenient for both families and nannies.
• Digital Scheduling: Advanced scheduling tools help parents manage and coordinate with their nannies more efficiently.
• Enhanced Training Programs: Continuous professional development programs ensure that nannies stay updated with the latest childcare techniques and methodologies.

These advancements aim to enhance the efficiency and effectiveness of nanny services, ensuring that families receive the best possible care for their children.

Conclusion

Babysitter in Gurgaon provide a robust solution for parents seeking dependable and high-quality childcare. By offering experienced, well-trained, and compassionate nannies, these services play a crucial role in supporting families and ensuring the healthy development of children. Whether you need full-time assistance or part-time support, nanny services in Noida are equipped to meet your needs with flexibility, professionalism, and dedication.
In a city where work-life balance is essential yet challenging to achieve, having a trustworthy nanny can make a significant difference. The peace of mind that comes from knowing your child is in capable hands allows you to focus on your professional and personal responsibilities, contributing to a more balanced and fulfilling life. As the landscape of childcare continues to evolve, nanny services in Noida remain an indispensable resource for modern families, ensuring that every child receives the care, attention, and nurturing they deserve.
In the bustling city of Noida, where many families juggle demanding careers and busy lifestyles, the need for reliable and professional childcare has never been greater. Nanny services in Noida have emerged as a vital support system for parents, offering tailored care that ensures the safety, well-being, and development of children. These services provide a range of options, from full-time and part-time nannies to live-in caregivers, each designed to meet the unique needs of families.

Combined plastic surgeries are operations in which more than one plastic surgery is performed together at the same time due to a need or request. Two or more operations at the same time should be performed after the doctor’s approval and the patient’s demand.
Requirements Of The Combined Aesthetics:
While safety is always the top priority, many cosmetic surgeons are comfortable combining at least two surgeries but you need to have;

• Sufficient time for recovery and strong body
• Sufficient blood values.
• Individuals who are very old and have chronic diseases can not undergo combined aesthetic surgery

What Are The Advantages Of Combining Procedures?

• Less Need for Anesthesia
• Minimizing the Cost
• Less Overall Recovery Time
• A More Dramatic Transformation
• Less Downtime

The Most Common Combined Plastic Surgeries:

• Tummy tuck and liposuction
• Breast surgery, tummy tuck, and liposuction (mommy makeover)
• Facelift and blepharoplasty
• Rhinoplasty and chin augmentation
• Breast lift and breast augmentation

Hello you lovely Spuds!
I'm an American expat living in England with my husband and our child (F7). My husband and I have been together for 8 years, our daughter was a happy accident but it took me at least 6 years to see my husband was the one I should not have kept.
For background: he is an alocholic since day 1, he made me thank him profusely for deciding to stay for the baby because he just wants to live his own life as a bohemian artist, he made us late for our own baby shower because he screamed at me and threw food at me for 2 hours in a parking lot because I bought him some Mcdonalds breakfast due to him being newly wasted at 9am, he proposed to me because his dad was visiting and wanted him to be proud of him - and when he saw his dad was drunk and missed it he got so angry and made us all go home - and then forgot he even proposed, (for the record, I didn't say yes because his friends were pouring beer on us and I wasn't sure I wanted to marry him but he told everyone I said yes and I wasn't capable of standing up for myself at the time). The day of our wedding I wore black and watched a zombie film in the bath haha that's not part of the story just something I'll always remember as symbolic. Of course he was wasted for our family meal reception and kept trying to dry hump his male friend which was weird, but ok. Then ruined seeing Phantom of the Opera for our honeymoon and then admitted to sleeping with his ex when I was newly pregnant (that he repeatedly told me I was crazy for thinking he'd sleep with that 'expletive expletive'). It gets a lot worse for about 3 years while we were in separate countries and waiting on a visa for me as our daughter and I visited a few times for a few months. Lots of binged weekends where he would be gone for days doing various illicit substances and lots of alcohol.
Fast forward to about a year ago and we al live together in England, still having binge days and sometimes things were good and sometimes not so good. the final straw was last March when I had mentioned I might go to a mums-night-out as I didn't feel like I had many friends at the time in England, and he said "I can deal with you being a shit wife but I can't deal with you being a shit mother" because my daughter didn't want me to be gone. Later he told me he only said it to hurt me. The moment he said that to me was the moment everything I was holding onto just died. I'm a massive planner and decided to learn what I actually want out of my life and how to make my own choices and have significantly leveled up since then, I made a 110 page life plan that broke down my life into 13 categories - I was serious about change. I watched "how to talk to narcisstist" videos and stopped allowing him to talk down to me and drive conversations in circles. It was last March when I made this shift and I've just managed to move out last weekend! In that year, he broke my fridge, ruined my bed because he doesn't shower, and shattered my oven glass door because "I made him angry by telling my friends about the situation and making him look bad." He never bought anything because he doesn't work, and the money he does get from his art doesn't go into the family or home. Oh also, I'm his second marriage as he has a case in the states against him for DV but said he only hit her back "in self defence" and he is a wonderful storyteller, clearly. I know, I'm an idiot.
ALL THAT BEING SAID, my visa relies on being married to him and I now have to urgently choose to pay £5k to apply as a parent to my English daughter and will be restarting the whole 5 year visa process which will end in over £10k -or- I could apply for the Domestic Abuse visa which in the long run is waaaaay better for me and my daughter but he would know I did that and would be so angry as he's told me off for "playing the victim" when I reported him to the police and social workers needed to get involved. Since this new year we've had a mostly good relationship as we live completely separate lives and have agreements where our daughter is involved. I feel awful because his parents have helped me so much throughout the visa process and with getting my English license and a car, and until last week I lived in a granny annexe in his mothers back garden with him. I feel like if I apply for DA then its like a slap in the face to his family for everything they've done for me and could potentially isolate myself and my daughter from family in the UK. They know about his character but choose not to acknowledge it and think we just need work things out. I also feel like as it wasn't physical abuse that I am sort of "playing the victim" and shouldn't deserve to apply for it. I don't want to bring my daughter back home to the states as I'm very happy with the safety and quality of life here for her compared to where I'm from, also I'm not even sure if I could as I'd be then taking her away from her dad and english family and friends.
Am I the asshole for wanting to make this massive decision that would then legally label him as an abuser (in the UK) as it would be the most beneficial route for me and my daughter?
Lastly- I am receiving professional support and not relying on internet crowdsourcing support, I'm just so stressed and nervous and there are massive time gaps with the professional support where I 120% overthink these things!!!