Dealing with the mother in law is hard enough, but can you imagine if you also need to deal with his sisters?
His oldest sister is living next door with her husband and her parent in laws. Her husband has a little bro. According to what she said, the brother is spoiled by the parents and she dislike him. Therefore, her front door uses key because she doesn’t want the brother to come so easily and so often. But our front door uses passcode, and she came over to our house every weekends at that time. She stayed the whole day in our house on weekends.
My husbands father has diabetes and needs kidney dialysis. Most of the time, his second sis is the one who took him to the doctor or hospital. But she needs to work, so my husband also needs to help from time to time. However, whenever they ask the oldest sis to help with the dad, she would say, I am married out already. In my memory, she seldom took the dad to the doctor or the kidney dialysis. I am not good at driving, and was pregnant at that time, I picked his dad up from the hospital once (what is ironic here is that his second sis thought it was their oldest sis picked them up from the hospital even though she is the one also complained the biggest never helped), helped his second sis to send his dad to the kidney dialysis ( because she needs people to help the dad get out or in the car), and helped with translation for his dad’s physical therapy when his second sis was not available. In January of 2021, his dad’s situation is very bad and the nurse asked them to make a decision if the hospital should save his life if ….. the chance is only 50/50, and even though he was saved, he would have to do kidney dialysis for the rest of his life, and he also would have to have his leg amputation. Considering his life quality and the care taking part, his mom and second sis agreed to let him passed away naturally if that really happens. My husband had a hard time making the decisions. The oldest sister kept crying over there, and said we should not give up his life. Suddenly, she turned to me and asked about my opinion. Then I expressed my opinion, if you guys decide to save his life then you guys should share the responsibility of taking care of him and help with doctor visit and kidney dialysis, but you guys also need to think about his life quality and the fact that he would lose his legs. His second sis agreed with what I said, and my husband agreed with his mum and second sis at the end The oldest sis also agreed with then after her husband s persuasion. After his dad passed away, the oldest sis is the one cried the hardest, and the mum told one of their aunt on the phone how sad the oldest daughter is, and asked her not to cry so much, otherwise her health might be affected. Mam, you should show your love and contribute more to your father when he s still alive.
After I had my first kid, especially my relationship with my mother in law was like freezing at that time, my husband and I would go to visit my parents every weekend, one reason is that I could escape that prison like house, the other reason is that my parents could help me with the baby there so that I can rest a little bit. However, I accidentally found out she complained to my husband about me in the message why I always showed them bitchy face at home and why would I go back to my parents house every weekend. But the fact is she came over to our house more often when their dad’s situation was bad. And after the dad passed away, she still came over very often, which lead to her mother in law yelling at her at one time(when her father in law was in hospital because of Covid), saying no daughter in law would go back to her mums house so frequently. She’s lucky to have her husband to back her up by then. And she came over to our house to complained about it, and said I was married to her son but not selling myself to his family. My mother in law told her to keep quiet then the situation would become better.
Talking about the message, how I found out she bitched about me and my family is also very interesting. Thats like when my son was like about 8 months old, my husband told me to let his mum to watch the baby a little bit and would go grocery shopping with me after that meeting. I was waiting for my husband in his office room, and his mom was holding the baby to nap. I left my phone in the living room, so I played with my husband s phone. I accidentally went to the message, and saw that the last msg his oldest sis said is if you go bankrupt don’t expect me to help you. I was wondering what would make her say this. Then I went into their msg. The first time I found out that actually she had so many complaints about my family and me. So my husband got my dad a free tablet through promotion and he shipped it to our house for setup. She saw that package with my dad’s name on it. Second sis said it might be sending here for set up. In the text she told my husband that she wanted to get a tablet and ask for suggestion. My husband asked why would u need that, you don’t use that. Then she said is this your father in law s Xmas gift? My husband explained that’s through a promotion, not he buying it. Then she said, I guess he would not get a Christmas gift since you already got him a house! lol my dad paid half of that retirement house. And because my sis and I could not get a good rate, my husband said he could help, but my sis s side will be responsible for half of the mortgage. My husband s name is also on that title! How come this house would become my dad’s Christmas gift? And in the message, she also said she s not as lucky as me, no need to wash dishes at home. But the fact is I am the one who cooked most in our house and did most of the dish cleaning before my baby came out, I am the one who cleaned the house all the time. I didn’t do so many dishes wash after the baby was born because I needed to take care of the baby and power pump is very exhausting for me at that time. For her, she doesn’t cook much at her house, because either her father in law cook or the parent in laws bring food home when they are off work or her mum would cook and ask the second sis to bring food over! And her parents in laws would clean the whole house every Wednesday at that time! Reading this I felt super angry, my face was burning and my heart was about to jump out of my breast! I directly replied bitch to her! I hung up on her when she called my husband s phone. After my husband finished the meeting , I said, “ u r in trouble now, because I just called your sis bitch!” She called my mother in law saying the brother curse her. And MIL came knocking at the door, disregarding if my husband is still in the meeting or my son was napping in her arm. She asked my husband why cursed his sis! I couldn’t stand any more, then I exploded, and questioned her why every time you defend your daughter no matter shes right or not. Do you know what she said about my parents and me in the message. I also directly called her bitch and claimed that it's her who kicked my mom out of our house when she was here to help me! That became a big arguement and I took my son back to my parents house right after the arguement.
Because of my husband, I tried to fix the relationship after half a year, and also we have our own house now.
However, just two days ago (5/14), his oldest sis called him around 10:30pm using second sis s phone because her husband got her a new phone and would like my husband to set it up for her. Her old phone is still usable, why the new phone must be set up now? And my husband is wondering why she’s not using the her husband’s phone to call but second sister’s phone. My husband went to check and found out she moved into our house, where his mom and second sis are living, with her 18 month son . And He traced that she was living there since 3/16. Not sure about exactly when as the history can only go back to two or three months. My husband and his second sis are the owners, and my husband is helping paying the mortgage ( before we moved out, he is the only one paying the mortgage). Why no one telling us about her move in. And we are sure she has no issue with her husband and parents in law because the husband just bought her the new iPhone and she s living in our house on weekdays, but on weekends she would go back to her own house. How hypocritical it is! When my son was about 8 months old she complained we went back to my parents house every weekend. But now she moved into our house even though her house is next door !!! My husband called the second sis and told her about this, expressed his disappointment about not letting him knowing this, telling her this whole shit is basically slapping my face. And also told them we are not going to NC trip with them. BTW, a few days ago, his oldest sister texted my husband asked him to go back to that house help clean the doggie this week, before the NC trip. Why the heck you live there , eat there, free baby sitter there, you can’t clean the dog with your sister?!!!

What is Ikaria Juice ?

Ikaria Juice is a powdered supplement that contains a sophisticated superfood blend. It contains several natural mixes that are designed to help with fat storage, anti-inflammatory effect, appetite control, cravings, and quicker digestion. It kick-starts weight loss by targeting fat deposits that do not respond to diet or exercise.
Ikaria Lean Belly Juice contains components that may aid in the reduction of metabolic variables. These components have been utilised in numerous traditional medicines for hundreds of years and have been scientifically confirmed to provide these effects. So, regardless of your age, diet, degree of exercise, or job schedule, this product may help you lose weight.
~Ikaria Juice~ is the best-suited supplement for those who are facing obesity problems and want to get rid of it and all its other effects.Each and every batch of Ikaria Juice has been made under strict, sterile, and precise standards that ensure high quality and safety and also easy-to-use formula for daily consumption.
Ikaria Juice is a fat burning formula developed to make the metabolic modifications the body requires to drop weight. The Supplement aims to promote healthy weight loss in people who have difficulty maintaining a healthy weight. To avoid side effects, Ikaria Lean Belly Juice uses only natural ingredients in its formulation. Citrus pectin, African mango extract, milk thistle, resveratrol, and Bioperine are ingredients in Ikaria Lean Belly Juice. All these ingredients are sourced from reliable sources to provide you with various health benefits.

How Does Ikaria Juice Formula Works?

The Ikaria Juice flushes away ceramides and renews your body from inside. It contains Milk thistle, citrus pectin, bioperine, and other ingredients that aid in weight loss. Some elements in Ikaria Lean Belly Juice give antioxidant assistance to the body. Milk Thistle is a natural fat burner that also helps to promote liver function and regulate blood sugar levels.
~Ikaria Juice~ has a metabolic combination that helps to stimulate your metabolism and raise your energy levels. One of the primary causes of excessive weight gain is a sluggish metabolic rate. An increase in abdominal fat may cause your body to produce more uric acid. Increased uric acid levels can harm joint health and cause tissue damage, as well as renal and heart issues.
Ikaria lean belly Juice is a powerful and effective supplement that offers a multitude of health benefits. Apart from its Ceramide-relieving properties, this juice contains a unique blend of other nutrients that are essential for maintaining overall health and well-being. These nutrients are known as “the other 30%” and are specially formulated to improve energy levels and enhance your appearance.
Ikaria Juice is also effective in relieving symptoms of Ceramide paresthesia, leading to increased sensation anddrag on the stomach. These benefits cannot be overemphasized. Therefore, if you are looking for an effective way to reduce behemoth fat accumulation, this is the perfect product for you. In addition to its Ceramide-relieving benefits, the Ikaria Juice contains a unique blend of otherprestige nutrients that will help to improve your overall health. These nutrients, which are known as “the other 30%”, are specially formulated to improve your overall energy and look.

Ikaria Juice ingredients

Ikaria Juice uses top ingredients that are of high quality. The ingredients are sourced from their natural environments and are of the greatest quality.
Below is a list of the various ingredients that make up this formula, along with their supposed advantages for your body:

• Panax Ginseng: Panax ginseng, known for its medicinal properties found in its roots, has been used to help lower blood pressure. It is also used to shrink fat cells and promote weight loss. In addition, it is utilized to boost energy levels, making it an essential ingredient in the Ikaria Lean Belly Juice, as it helps in both burning fat cells and increasing energy levels.
• Milk Thistle: The Ikaria Lean Belly Juice is a powerful and effective tool for regulating blood sugar levels in the body. The initial ingredient on the list of its components is milk thistle. Milk thistle helps to regulate blood sugar levels in the body, and has a powerful fat-burning effect on the body.
• Fucoxanthin: Ikaria Lean Belly Juice includes fucoxanthin, which activates a protein that transforms fat cells into energy and heat. Fucoxanthin, derived from seaweed, is rich in phytonutrients with antioxidant properties, as per studies. An increasing number of weight loss aids and anti-inflammatory supplements utilize fucoxanthin. The creators of Ikaria Lean Belly Juice state that fucoxanthin can also aid in maintaining healthy blood sugar levels and possesses anti-obesity effects, among other benefits.
• Bioperine: Bioperine, a piperine extract, increases the absorption of essential nutrients and plant compounds. It promotes weight loss by preventing the formation of fat cells in the body, while also enhancing cognitive health. Additionally it supports overall well-being of an individual with the help of essential nutrient and plant compounds.
• Citrus Pectin: When high-quality natural ingredients are used in a dietary supplement, the outcomes tend to be positive. One crucial ingredient in Ikaria Lean Belly Juice is citrus pectin. To support healthy weight loss, this component addresses cravings. It suppresses hunger more effectively than a protein diet and also helps to eliminate toxic metals from the body. The slower digestion of pectin causes a feeling of satiety for a longer period, leading to less consumption of food and initiation of weight loss process.

Benefits Of Ikaria Juice

• Ikaria Juice Supports physical activity to reduce calorie intake and prevent weight gain.
• Ikaria Juice Ensures Prevention Of Several Fatal Diseases.
• Curbs Appetite and Reduces Cravings.
• Ikaria Juice Can Help Prevent Fatty Liver Disease and Burns Stubborn Fat.
• Lowers Cholesterol And Diabetes Levels.
• Promote Healthy Weight Loss and Boosts Overall Health.
• Ikaria Juice Made with scientifically validated vitamins.

Hi, I'm a type 1 diabetic and WARNING: NOT A DOCTOR OR MEDICIAL PROFESSIONAL of ANYKIND. I have not verified this info with my endo or any professional for that matter, and I know a lot of you may come in and question this, but I tested this on myself and for nearly two months now, have had much more stable BG. I use a Tandem T:Slim X2 Pump paired with a Dexcom G7 for reference.
Again, this may not work the same for everyone.
Formula to find TDI or TDD (Total Daily Insulin/Dosage)
Weight divided by 4 equals TDI
Wt / 4 = TDI
Formula to find Basal rate
Multiply TDI by 0.75, then divide that by 2. It will equal a variable number. (M). Take M and multiply that over the solution to 1 divided by 24.
(0.75 x TDI) / 2 = M
(M) * (1 / 24) = Basal Rate/ HR
Formula to find correction ratio
1500 divided by TDI equals your correction ratio in the format of 1:x
(1500 / 55) = 0.27272727…
Formula to find Carb ratio
(500 / TDI) = Carb ratio in the same format as correction.
(500 / TDI) = 1:y

Examples:
225lbs / 4 = 56.25
56.25= TDI
Then,
(0.75 x 56.25) / 2 = 21.09375 (Variable Number)
Finally,
(21.09375) * (1/24) = 0.87890625 (Basal Rate)
Your hourly basal rate is 0.87890625 and can be rounded.
To find your correction ratio
1500/56.25=26.66666666667 or 26.7 or 27.
Correction formula= 1:27u
Similarly, to find your carb counting ratio
500/56.25=8.88888889 or 8.9. (Try to avoid rounding your carb ratio. It needs to be as precise as possible.)
Your carb ratio would be 1:8.9u.
If you find your target BG is above range for 2-3 days then DECREASE ratio by 10%-20%. If below range for 2-3 days, INCREASE by 10%-20%.

DISCLAIMER: I am not any sort of medical professional. I did not get these findings looked at by a second person or endocrinologist. I have been a type 1 diabetic since 2003 and did research on my own using various sources from college studies and other reports online. I felt that I wasn’t getting enough results from the settings I had and my doctor’s wouldn’t divulge how to find these numbers. Using this information is at your own risk. Personally, changed my numbers from what I had to using these formulas and while it wasn’t a drastic change, it was immediately felt and I noticed my blood glucose levels stabilized. The other purpose of this was to help myself lose weight. Insulin is the hormone that causes weight gain, research it. If your taking in more and more insulin, your adding more and more weight. Losing weight is already difficult enough but as a Type 1 Diabetic, you need to go that much further to do it correctly. I hope this helps or at least draws some attention for the better of Type 1 Diabetics health across the world.

Hello.
A quick background: I am having PVC's since last august (consistent %6 burden). I did ECG's, multiple holters throughout the year and even cardiac MRI. Nothing came out. Since the beginning I was perscribed bisoprolol 2.5mg then increased to 5mg. I have been taking 5mg every day for 6 months now. My resting heart rate is around 48-52 constantly. However, I don't think bisoprolol is helping my PVC's as I keep having them since day 1.
2 weeks ago, I started feeling a tingling sensation in my right hand (upper area) and my right feet (around the heel). It sometimes comes with a burning sensation and/or itchy. It keeps coming on and off (though mostly on) and keeps moving around my both feets and hands. I have it on my right a couple of hours and then it moves to left for a couple more hour then I have it on both for a couple of hour etc. I did blood test for b12, diabetes and also got checked for MS which all came back as normal.
My question is, I see bisoprolol has a side effect which somehow explains my symptoms however doctors are quickly dismissing the idea that it is caused by it. Does anyone has something like this? I am thinking off weaning off bisoprolol slowly as my doctor previously said that I can stop taking them if I don't want them.
I would be glad if anyone with similar experience has anything to add here.
Thanks

Malaysia ranks 12th in the world for diabetes. For comparison, the US, one of the fattest countries, is ranked 55th. We rank higher than Mexico(17th), a country for which Al Jazeera made a documentary to talk about their diabetes crisis.
We all love our Milo trucks in school, but think about it, it's Nestle trying to get kids addicted to sugar from 7 years old! Meanwhile Australia started banning sugary drinks in schools since 2006.
How much did Nestle even pay KPM/MOE to allow them to pause classes so they can advertise in schools??
When you buy kopi or teh, it comes by default with condensed milk. Meanwhile in many countries, a cup of latte has no sugar in it at all.
It will take decades for society to get used to less sugar, but we need our politicians to focus on public health more. Maybe start by banning outright advertising of sugar in schools - a nostalgically painful, but logically irrefutable move.
Source: https://wisevoter.com/country-rankings/diabetes-rates-by-country/

DAY: MAY 15, 2024

• 5-15-2024ALZHEIMER’S DISEASE PROCESSES WITHOUT SYMPTOMS. HOW IS THAT POSSIBLE? Everyone experiences aging in their own way, and factors such as genetics, lifestyle and environment play a role in this process. Some individuals reach the age of 90 or even 100 in good health, without medications or brain disease. But how do these individuals maintain their health as they age?
• 5-15-2024COULD A LOW-CAL KETO DIET HELP EASE ACNE? In a small pilot study, some young women looking to lose weight on a low-calorie keto diet got an unexpected benefit: Their acne began to clear up. “These findings represent an opportunity to control a skin disease that affects most teenagers and many adults at some point in their lifetimes, causing distress, embarrassment, anxiety and low self-confidence among sufferers, robbing them of their quality of life,
• 5-15-2024FIGHTING FAT AND INFLAMMATION: SCIENTISTS DEVELOP NEW COMPOUNDS The menthyl esters of valine (MV) and isoleucine (MI) are multi-faceted molecules with enhanced anti-inflammatory and anti-obesity activities. The discovery and development of such molecules can result in newer classes of therapeutic drugs to treat a wide range of metabolic disorders. Credit: Gen-ichiro Arimura from Tokyo University of Science Modified derivatives of natural products have led to significant therapeutic advances and commercial success in recent times. Menthol is a naturally occurring cyclic monoterpene alcohol found in various plants,
• 5-15-2024TREATMENT OPTIONS INCLUDE ALTERNATIVES TO CHEMOTHERAPY, EXPERT EXPLAINS Chemotherapy is usually the first treatment doctors try to treat lymphoma, including the two most common forms: non-Hodgkin and Hodgkin. But alternatives to chemotherapy are developing, as first-line treatments and as backup options, explains Stephen Ansell, M.D., Ph.D., hematology chair and hematologic oncologist at the Mayo Clinic Comprehensive Cancer Center. Lymphoma is a blood cancer that begins when a germ-fighting white blood cell, called a lymphocyte, mutates and rapidly multiplies
• 5-15-2024CHECKING YOUR BELLY BUTTON CAN TELL YOU A LOT ABOUT YOUR HEALTH Navels, belly buttons, innies or outies … whatever term you use, your umbilicus may have plenty to tell you about the state of your health. For some, they are the thing of nightmares—omphalophobia (the fear of belly buttons) is a real condition. For others, they are a fashion accessory to be shown off in a crop top, or decorated with a body piercing. Whatever your feelings about belly buttons, one thing’s for sure—it once joined you to your mother
• 5-15-2024STUDY FINDS H5N1 VIRUS FROM 2022 MINK OUTBREAK CAPABLE OF INEFFICIENT AIRBORNE TRANSMISSION Direct contact transmission, weight loss, and survival for ferrets infected with A/mink (H5N1). Four donor ferrets were inoculated with A/mink (H5N1) and 24?h later each donor was paired with a contact in the same cage. Nasal wash samples were collected every other day for 13 days, and weight loss and clinical signs were monitored. A, B display viral titers from donor and direct contacts,
• 5-15-2024STUDY SHOWS COMBINING JOYFUL ACTIVITIES WITH ‘SAVORING’ THERAPY SHOWS POSITIVE MENTAL HEALTH RESULTS AMONG YOUNG PEOPLE With rates of depression rising among young people on university campuses, a team of SMU researchers found that combining two different therapeutic approaches demonstrated effectiveness in improving students’ overall mental health. Their findings show that students receiving behavioral activation (BA) therapy augmented with savoring (S) experienced improvements in positive and negative mood. Behavioral activation is a therapeutic approach that alleviates depression by increasing engagement in meaningful activities,
• 5-15-2024AI-BASED SURGICAL PREDICTION MODELS HAVE LIMITS Prediction models generated by machine learning are being increasingly used in medicine to identify risk factors and possible outcomes, especially for total joint replacements of knees and hips—although researchers warn that machine-generated predictions are currently being drawn from a limited data pool. “Machine learning has great potential for processing ‘big data’ and has proved its undeniable capability, although it is not free of issues,
• 5-15-2024STUDY FINDS FRONT-OF-PACKAGE NUTRITION LABELING RESULTS IN HEALTHIER PRODUCTS A study finds that a food labeling system introduced by the French government in 2017 resulted in healthier products. The study of Nutri-Score, a voluntary labeling system that assigns a simple letter grade based on nutrition, is believed to be the first to examine how food manufacturers responded to the change. Using detailed product and nutrition data from 2014 to 2021,
• 5-15-2024EXPERT EXPLAINS PUBLIC HEALTH CONCERNS ON AVIAN FLU Using genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading into drug eruption. This implies that HLA is involved in previously unknown signaling pathways and processes that go beyond its traditionally accepted role within the immune system.
• 5-15-2024EXPLORING THE MECHANISM BEHIND DRUG ERUPTIONS IN THE SKINUsing genetically engineered mice expressing a specific variant of HLA, researchers uncover the instrumental role of this protein in the development of drug eruptions. They found that when HLA binds to an antiviral drug, abacavir, it can lead to the formation of defective proteins, which trigger a stress response in the endoplasmic reticulum, ultimately cascading into drug eruption.
• 5-15-2024STUDY PROVIDES BLUEPRINT FOR HYBRID-VIRTUAL HOME VISIT MODEL TO SUPPORT PATIENTS WHO DO NOT LIVE CLOSE TO A HOSPITAL a team developed and successfully tested a hybrid-virtual home visit model that provides care to veterans who do not live close to a VA health care facility.
• 5-15-2024HOW SCIENCE IS CHANGING THE GAME IN SPORTS Digital twins of athletes allow athletes and coaches to evaluate performance and trial technique changes. It’s an open secret that the countries that win the most medals in the Olympics and Paralympics combine talent and technology. Athletes are preparing for the next three Olympics and Paralympics in Paris in 2024
• 5-15-2024STUDY REVEALS HOW PRACTICE FORMS NEW MEMORY PATHWAYS IN THE BRAIN The effects of optogenetic inhibition on WM task performance. a, The experimental set-up. b, The delayed-association WM task trial types; licking was assessed during the 3?s choice period, with early- and late-delays periods noted. c, Learning progress across eight sessions, measured on the basis of the percentage of correct responses. d, Learning session example
• 5-15-2024A MEDITERRANEAN DIET CAN EASE SYMPTOMS OF STRESS AND ANXIETY, SAYS STUDY It’s no secret that the Mediterranean diet is good for your health. Already recommended to reduce the risks of bowel cancer, heart disease, and dementia, new research shows that the Mediterranean diet can also reduce symptoms of stress and anxiety.
• 5-15-2024ENHANCING PATIENT RESPONSE TO CANCER IMMUNOTHERAPY
• 5-15-2024LONGER SPRINT INTERVALS CAN IMPROVE MUSCLE OXYGEN UTILIZATION COMPARED TO SHORTER INTERVALS
• 5-15-2024NEW EVIDENCE FOR USE OF ANTI-INFLAMMATORY THERAPY FOR PREVENTION OF RECURRENT VASCULAR EVENTS IN STROKE
• 5-15-2024STUDY PAVES THE WAY FOR AN ACTIVE AGENT AGAINST HEPATITIS E
• 5-15-2024RESEARCHERS DEVELOP METHOD TO MONITOR PATIENTS WITH SPINAL MUSCULAR ATROPHY USING SOUND WAVES
• 5-15-2024INFERTILITY TREATMENT FOUND TO DOUBLE THE RISK OF POSTPARTUM HEART DISEASE
• 5-15-2024A PROMISING APPROACH TO INTRAOPERATIVE CANCER DIAGNOSIS
• 5-15-2024HOW ROGUE NEUTROPHILS HELP LUNG CANCER SPREAD
• 5-15-2024WOMEN PHYSICIANS ARE UNDERREPRESENTED AND FEEL LESS IMPACTFUL IN CANCER TREATMENT PLANNING VIRTUAL MEETINGS
• 5-15-2024ONLY 20% OF U.S. NONPROFIT HOSPITALS INVESTED IN HOUSING AS PART OF THE FEDERAL COMMUNITY BENEFIT MANDATE
• 5-15-2024NEW STUDY LINKS AUTISM SPECTRUM DISORDER TO DISRUPTED DEVELOPMENTAL DOPAMINE
• 5-15-2024STUDY FINDS SEVERE ISCHEMIC STROKES ARE RARE IN PATIENT POPULATION
• 5-15-2024CYCLIN D1 EXPRESSION MAY BE A BIOMARKER FOR PENILE CANCER
• 5-15-2024GUIDELINE ISSUED FOR PEOPLE WITH EPILEPSY WHO MAY BECOME PREGNANT
• 5-15-2024NEW CARDIAC RESEARCH COULD SAVE WOMEN’S LIVES BY IMPROVING DETECTION OF HEART FAILURE
• 5-15-2024PATIENTS REPORT SIGNIFICANT SYMPTOM REDUCTION WITHIN A SINGLE INTEGRATIVE MEDICINE ENCOUNTER
• 5-15-2024STUDY LINKS PROTEIN SECRETED BY BLOOD VESSELS TO DRUG-RESISTANT CANCER
• 5-15-2024RESEARCHERS EXPLORE THE ROLE OF OF TRANSPOSABLE ELEMENTS IN MYOCARDITIS
• 5-15-2024STUDY REVEALS IMMUNOTHERAPY’S POTENTIAL IN BOOSTING IMMUNE SYSTEMS OF OLDER INDIVIDUALS
• 5-15-2024CANADIAN HOSPITAL DATA SHOW LONGER, COSTLIER STAYS FOR PATIENTS EXPERIENCING HOMELESSNESS
• 5-15-2024SCIENTISTS WANT TO KNOW HOW THE SMELLS OF NATURE BENEFIT OUR HEALTH
• 5-15-2024STUDY FINDS TWO GENES OF THE GERMLINE ARE ESSENTIAL FOR THE DEVELOPMENT OF BRAIN TUMORS IN DROSOPHILA
• 5-15-2024EVALUATING A NEW GROUP TRAINING TOOL FOR THE PREVENTION OF DEMENTIA
• 5-15-2024RESEARCH CHALLENGES LINK BETWEEN MOTOR IMPAIRMENT AND BRAIN INJURY
• 5-15-2024RESEARCH CHALLENGES LINK BETWEEN MOTOR IMPAIRMENT AND BRAIN INJURY
• 5-15-2024CHIROPRACTIC ASSOCIATED WITH LOWER LIKELIHOOD OF TRAMADOL PRESCRIPTION IN ADULTS WITH SCIATICA
• 5-15-2024UNVEILING THE IMPACT OF JOB LOSS ON THE HEALTH OF IMMIGRANTS IN GERMANY
• 5-15-2024HEALTH CARE INTERPRETERS IMPORTANT FOR HEART ATTACK REHABILITATION, SAYS STUDY
• 5-15-2024RESEARCHERS FIND MICROPLASTICS IN CANINE AND HUMAN TESTICULAR TISSUE
• 5-15-2024ANTISEIZURE MEDICATIONS CAN PRODUCE LIFE-THREATENING REACTIONS
• 5-15-2024ADULTS WHO HAD DIFFICULT CHILDHOODS ARE NOT RECEIVING SUFFICIENT MENTAL HEALTH CARE, FINDS CALIFORNIA STUDY
• 5-15-2024AI MAY IMPROVE DOCTOR–PATIENT INTERACTIONS FOR OLDER ADULTS WITH CANCER
• 5-15-2024BLOOD PRESSURE DRUGS MORE THAN DOUBLE BONE-FRACTURE RISK IN NURSING HOME PATIENTS
• 5-15-2024PREVENTING PEDIATRIC FALLS
• 5-15-2024I’M PREGNANT. DO I NEED A MULTIVITAMIN?
• 5-15-2024TREATMENT-RESISTANT DEPRESSION LINKED TO BODY MASS INDEX: STUDY
• 5-15-2024HOW DID THE COVID-19 PANDEMIC AFFECT OLDER ADULTS’ TECHNOLOGY USE?
• 5-15-2024STUDY FINDS LINK BETWEEN BMI TRAJECTORIES AND FRACTURE RISK IN LATE ADULTHOOD
• 5-15-2024STUDY FINDS REDUCED RISK OF BREAST CANCER FOLLOWING BARIATRIC SURGERY IN WOMEN WITH HYPERINSULINEMIA
• 5-15-2024FEWER US OVERDOSE DEATHS WERE REPORTED LAST YEAR, BUT EXPERTS ARE STILL CAUTIOUS
• 5-15-2024PRE- AND POST-SURGICAL IMMUNOTHERAPY IMPROVES OUTCOMES FOR PATIENTS WITH OPERABLE LUNG CANCER, PHASE III STUDY FINDS
• 5-15-2024NEW METHOD USES TAU PROTEIN DEPOSITION PATTERNS TO PREDICT ALZHEIMER’S SEVERITY
• 5-15-2024OLDER NATIVE AMERICANS MAY EXPERIENCE HIGHER LEVELS OF COGNITIVE IMPAIRMENT THAN PREVIOUSLY THOUGHT
• 5-15-2024RESEARCHERS DEVELOP INNOVATIVE PLATFORM FOR MODELING HUMAN MUSCLE DISEASES IN WORMS
• 5-15-2024CLIMATE CHANGE IS LIKELY TO AGGRAVATE BRAIN CONDITIONS, STUDY FINDS
• 5-15-2024NEW STUDY SHOWS CONTINUED HIGH EFFECTIVENESS OF HPV VACCINATION IN ENGLAND
• 5-15-2024FAT-ENLARGED AXILLARY NODES ON MAMMOGRAM MAY INDICATE HIGHER CVD RISK
• 5-15-2024NOVEL INHIBITOR INSIGHTS OFFER PATHWAY TO PREVENTING PXR-ASSOCIATED DRUG RESISTANCE
• 5-15-2024THE DOCTOR IS IN… BUT WHAT’S BEHIND THEM? STUDY REVEALS IMPACTS OF TELEHEALTH BACKGROUND SETTINGS
• 5-15-2024HIGH TELEHEALTH USE TIED TO INCREASED HEALTH CARE UTILIZATION, COST
• 5-15-2024NEW BIOMARKER IDENTIFIED TO DIAGNOSE ALZHEIMER’S IN ASYMPTOMATIC STAGES
• 5-15-2024U.S. DROWNING DEATHS RISING AGAIN AFTER YEARS OF DECLINE
• 5-15-2024STUDY FINDS ASTROCYTIC PH REGULATOR CAN REPAIR BLOOD-BRAIN BARRIER, REVERSE BRAIN DAMAGE CAUSED BY ISCHEMIC STROKE
• 5-15-2024DISPARITIES SEEN IN CARBAPENEM-RESISTANT ENTEROBACTERALES BLOODSTREAM INFECTION OUTCOMES
• 5-15-2024WHY IS WHOOPING COUGH SURGING IN THE UK? FALLING VACCINATION RATES MAY BE THE ANSWER
• 5-15-2024CARDIAC REHAB IS A PROVEN BUT UNDERUSED THERAPY IN WOMEN, BUT TAILORED RESOURCES AIM TO CHANGE THAT
• 5-15-2024IRON FUELS IMMUNE CELLS—AND IT COULD MAKE ASTHMA WORSE
• 5-15-2024NEW POSSIBILITIES FOR CELL THERAPIES AND PERSONALIZED MEDICINE
• 5-15-2024HIGHER INCOME REDUCES STROKE MORTALITY RISK BY A THIRD, NEW STUDY SHOWS
• 5-15-2024SOME FORMS OF AUGMENTED BRAIN STIMULATION RECOMMENDED FOR MAJOR DEPRESSION
• 5-15-2024LOW TESTOSTERONE IN MEN ASSOCIATED WITH AN EARLY DEATH
• 5-15-2024WEARING FACE MASKS DID NOT REDUCE RISK OF COVID INFECTION AFTER FIRST OMICRON WAVE, RESEARCH SUGGESTS
• 5-15-2024BLUETOOTH TRACKING DEVICES PROVIDE NEW VIEW INTO CARE HOME QUALITY
• 5-15-2024RACIAL DISPARITIES IN CHILDHOOD OBESITY ON THE RISE IN STUDY OF NYC PUBLIC SCHOOLS
• 5-15-2024TWO DECADES OF STUDIES SUGGEST HEALTH BENEFITS ASSOCIATED WITH PLANT-BASED DIETS, BUT CAUTION URGED
• 5-15-2024TRANSCATHETER VALVE REPLACEMENT OUTCOMES SIMILAR TO SURGERY FOR SEVERE AORTIC STENOSIS
• 5-15-2024RECOGNIZING THE PHYSICAL AND EMOTIONAL TOLL THAT CARING FOR A LOVED ONE WITH A CHRONIC CONDITION HAS ON THE CAREGIVER
• 5-15-2024DIFFICULT WORK ARRANGEMENTS FORCE MANY WOMEN TO STOP BREASTFEEDING EARLY—HERE’S HOW TO PREVENT THIS
• 5-15-2024DAY-LONG WORKSHOP IN COGNITIVE BEHAVIORAL THERAPY FOUND TO EFFECTIVELY REDUCE DEPRESSION IN 16- TO 18-YEAR-OLDS
• 5-15-2024REPORT HIGHLIGHTS BIG GAPS IN CANCER OUTCOMES BASED ON RACE
• 5-15-2024NEW BLOOD TEST COULD HELP SPOT PREECLAMPSIA IN FIRST TRIMESTER
• 5-15-2024HALF-MATCHED FAMILY DONORS OFFER BEST OUTCOMES FOR HISPANIC PATIENTS UNDERGOING BONE MARROW TRANSPLANTS: STUDY
• 5-15-2024SCIENTISTS UNRAVEL GENETIC BASIS FOR NEURODEGENERATIVE DISORDERS THAT AFFECT VISION
• 5-15-2024INCLUDING MORE WOMEN ON HOSPITAL TEAMS YIELDS BETTER SURGERY OUTCOMES, NEW STUDY FINDS
• 5-15-2024RESEARCH SHEDS LIGHT ON HOW PROTEINS LINKED TO ALZHEIMER’S DISEASE INFLUENCE NEURONAL GROWTH
• 5-15-2024RESEARCHERS IDENTIFY NEW MARKER FOR BREAST CANCER PROGNOSIS
• 5-15-2024GETTING OUT AND ABOUT IN THE COMMUNITY MAY BE LINKED TO COGNITIVE FUNCTION
• 5-15-2024NOVEL TECHNIQUE HELPS PREDICT RISK OF A MENISCUS TEAR IN THE KNEE
• 5-15-2024CAN ROBOT-INSPIRED COMPUTER-ASSISTED THERAPY BENEFIT CHILDREN WITH AUTISM?
• 5-15-2024RESEARCH FINDS EXERCISE HAS A SIGNIFICANT IMPACT ON IMMUNE CELLS THAT SUPPORT BRAIN FUNCTION
• 5-15-2024CARDIOVASCULAR DISEASES KILL 10,000 EUROPEANS A DAY: WHO
• 5-15-2024NEW TOOL CAN HELP SURGEONS QUICKLY SEARCH VIDEOS AND CREATE INTERACTIVE FEEDBACK
• 5-15-2024SCIENTISTS DISCOVER BLOOD PROTEINS THAT MAY GIVE CANCER WARNING SEVEN YEARS BEFORE DIAGNOSIS
• 5-15-2024HOW THEY IMPACT LIFESPAN IN VERTEBRATES
• 5-15-2024UN AGENCY AUTHORIZES SECOND VACCINE AGAINST DENGUE AMID OUTBREAKS IN THE AMERICAS
• 5-15-2024IF YOU’VE TRIED MEDITATING BUT CAN’T SIT STILL, HERE’S HOW—AND WHY—TO TRY AGAIN
• 5-15-2024RESEARCHERS DETERMINE THE MUTATIONS THAT PROTECT MICE FROM B-CELL CANCERS
• 5-15-2024UP TO 246 MILLION OLDER PEOPLE MAY BE EXPOSED TO HEAT RISK BY 2050 DUE TO GLOBAL WARMING
• 5-15-2024MORE RESEARCH SUPPORTS ANDROGEN TREATMENT FOR BREAST CANCER
• 5-15-2024UNDERSTANDING THE ROLE GUT MICROBIOME–BRAIN INTERACTIONS PLAY IN SOCIAL DECISION-MAKING
• 5-15-2024NEW STUDY IDENTIFIES MECHANISM OF IMMUNE EVASION OF SARS-COV-2 AND VARIANTS
• 5-15-2024RESEARCH SHOWS RECENT RELEASE FROM JAIL A BIG RISK FACTOR FOR SUICIDE
• 5-15-2024RESEARCH COLLABORATION DEVELOPS LIFESAVING ‘ARK’ TECHNOLOGY FOR CHRONIC KIDNEY DISEASE PATIENTS
• 5-15-2024FOUR IN 10 ADULTS WITH DIABETES REPORT TAKING A GLP-1 RECEPTOR AGONIST
• 5-15-2024NEIGHBORHOOD INEQUITY TIED TO MORE PEOPLE LIVING WITH VISION DIFFICULTY, BLINDNESS
• 5-15-2024CHILD MALTREATMENT LINKED TO EXTERNALIZING, INTERNALIZING BEHAVIOR
• 5-15-2024MOST SLOW RESPONDERS TO TIRZEPATIDE DO LOSE CLINICALLY MEANINGFUL WEIGHT
• 5-15-2024RESEARCHERS IDENTIFY CAUSATIVE GENE IN MOUSE MODEL OF INHERITED LETHAL ARRHYTHMIA
• 5-15-2024TECH ALONE CAN’T REPLACE HUMAN COACHES IN OBESITY TREATMENT, STUDY FINDS

Hi, I’m on my second week of Lumryz for Type 2 N and I’m also a Type 1 Diabetic. I noticed that my insulin sensitivity has increased while taking this medication. I have adjusted my correction factor and I suspect my basal rate will need to be adjusted as well since my blood sugar drops sometimes with no insulin on board. Still trying to figure that out. Has this happened to anyone else?? I haven’t seen any references about this being a possible side effect.

Obesity affects about 42% of the adult population in the United States and contributes to the onset of chronic diseases such as diabetes, cancer, and other conditions. Understanding the mechanisms behind this is crucial to combating the obesity epidemic. "We wanted to explore the mechanisms that might explain why late eating increases the risk of obesity," said Dr. Frank A. J. L. Scheer, the senior author of the study. Previous research indicated that late eating is associated with increased body fat and less successful weight loss.
The Study: Timing Matters The researchers asked, "Does the timing of our meals matter when all other factors are consistent?" The answer was a clear yes. Eating just four hours later than usual significantly affected hunger levels, how calories are burned after eating, and how the body stores fat.
In their controlled lab study, the team worked with 16 participants with a Body Mass Index (BMI) in the overweight or obese range. Each participant followed two eating schedules in the lab:
Normal Schedule: Eating at typical meal times. Late Schedule: Similar meals but eaten 4 hours later than usual. Before the lab sessions, participants maintained a fixed sleep-wake schedule for two to three weeks, and for the final three days, they followed a strict diet to standardize intake.
Measurements and Observations In the lab, participants reported their feelings of hunger and cravings, provided frequent small blood samples throughout the day, and had their body temperature and energy expenditure measured. To understand how meal timing affects fat storage pathways, the researchers also took fat tissue biopsies from a subset of participants under both early and late eating conditions for genetic expression analysis.
Study Findings: Hormones, Calories, and Fat Storage The study revealed profound effects of late eating on hunger and the appetite hormones leptin and ghrelin:
Leptin Levels: This satiety hormone was lower over 24 hours during the late eating condition compared to early eating. Calorie Burning: Participants burned calories at a slower rate when following the late eating schedule. Fat Storage Genes: Gene expression in fat tissue showed increased fat creation and decreased breakdown (lipolysis) under late eating conditions. These findings highlight the physiological and molecular mechanisms underlying the correlation between late eating and increased obesity risk.
Implications and Insights These findings align with a substantial body of research indicating that late-night eating can increase a person's likelihood of developing obesity. They elucidate how this might happen by revealing changes in different control systems related to energy balance. By conducting a randomized crossover study and tightly controlling behavioral and environmental factors like physical activity, posture, sleep, and light exposure, the investigators could pinpoint changes in different systems that control energy balance, providing a clearer picture of how our bodies use the food we consume.
This research suggests that modifying our eating times could be a straightforward approach to reduce obesity risk, improve metabolic health, and better manage appetite and fat storage.
Conclusion The study emphasizes that not just what we eat, but when we eat, plays a significant role in health outcomes related to obesity. Shifting meal times earlier could be a viable strategy for reducing hunger, improving metabolic rate, and ultimately aiding in weight management and obesity prevention.
https://youtube.com/shorts/qqFD1mZViis?feature=share
#NutritionScience #ObesityResearch #MetabolicHealth #HealthyEating #LateNightEating #WeightManagement #AppetiteControl #EnergyBalance #HealthAndWellness #DietAndHealth

Hi everyone, you know it’s that time of year :) I appreciate all the advice from everyone in advance. Please forgive formatting issues since I’m on mobile.
cGPA: 3.92 sGPA: 3.88
2 Bs in Freshman year, 1 in Junior (Biochem 😭)
Majored in Math at a college in Worcester, MA Class of ‘25 (am doing undergrad in 2.5-3 years 🙃). Am a permanent resident of the great state of Massachusetts 🇺🇸 🦅. ORM (Asian), Fam Income of ~250$k. No one in my fam has ever been in medicine. Dad has a BS and mom MBA.
MCAT: Most Recent - 514 (129/126/130/129) First Time - 509 (128/124/125/132)
For the following sections (present) denotes activities I am currently continuing.
Clinical Volunteering: 50 Hrs at UMass over the course of a year, restocked shelves, talked to patients, helped with food and other tasks on med-surge (1 year). Program director and I have good relation, boosted total number of volunteers via promotion.
150 Hrs as EMT on college campus, promoted to General position recently. take 12 hr on-call and run calls as a General.
Non-clinical Volunteering: 350 Hrs at a local organization focused on the visual impaired, worked with congressmen, Central Mass Regional Planning Committee, was on TV, and with medical students for clinical clerkships (2 years) (present)
150 Hrs as lead of community service of pre-med club, helped organized drives, goody bags, and other volunteer opportunities that connect students to local organizations in Worcester (2 years) (present)
Research: Quantitative Neuroscience Lab research volunteer to PhD working on measuring stress through microfluidic assays on C. elegans with induced PTSD. Lots of Python, MATLAB, microfluidic, and C. elegans experience. No pubs. 200 Hrs over 1 year.
Systems Neuroscience Lab research volunteer working on pollution in Alzheimer’s project in C. elegans. Learned how to do Calcium Imaging, several behavior assays, chemotaxis, and other forms imaging. Also mentored two HS students. Presented a slideshow about my research at college. Started working on a math modeling project. no pubs, have a draft of pollution Alzheimer’s paper. At least 400-500 hrs over 3 years (present).
REU in Maine at program with 7% acceptance rate. Worked in a lab focused on regenerative cardiovascular science for ischemic injury. My project focused on the differential gene and protein expression of retinoic acid and neuregulin interactions. Used lots of mathematical + AI modeling, qPCR, proteomics/LCMS, immunoblotting. Learned cell culture for human pluripotent STEM cells, learned how to harvest and creat fibroblast stock from mice cadavers, and how to use LCMS machines 5500 model and 6500. 2 posters. 450 hrs over the summer 2023.
New Zealand Dept. of Comservation project on incorporating Māori knowledge systems into invasive species (rodent) eradication. Ecological sciences project. 1 Paper. may also be published in NZ Journal of Ecology soon. 400 hrs Jan-Mar 2024
JUST STARTED Beth Israel Surgery Internship. Working on developing Machine Learning framework along with pt chart data to predict fracture risk in T1 diabetic patients. predicted 450 hrs over summer and guaranteed 1 poster, potential to work on other projects / write paper.
Shadowing - ENT 36 hrs - IM 10 hrs - EM 20 hrs - Cardiology 20 hrs - Orthopedic Surgery (predicted: 12 hrs)
Work: 200 Hrs over 2-3 Months working 24 hrs/week on top of college full time at an private institution ER as an ED technician
200 Hrs over 2-3 Months working 24 hrs/week on top of college full time at a public institution ER as an ED technician (but could also do phlebotomy work now too!)
Leadership: President of Pre-Health Honors Society (150 Hrs - 1 year) Community Service Chair of Pre-Health Club (150 Hrs - 2 years) General at EMS Club (150 Hrs - 2 years) Vice President of Japanese Club (150 Hrs - 2 years) Secretary of Italian Club (50 Hrs - 1 year)
LOR: Am getting a committee letter from college, but have the following as contributors - PI from Systems Neuro Lab - ENT surgeon i shadowed (really REALLY loved me - built him a prototype for medical tool for a research passion he had) - PhD from Maine REU - Math Prof i took a grad course with (she worked at Boston Scientific doing endoscope stats before becoming a stats professor) - NZ Project Mentor - UMass volunteer coordinator (TBD, should I?)
Personal Statement (quick summary by ChatGPT): My personal statement reflects a journey fueled by curiosity and empathy. It all began with my passion for mathematics, leading me to explore AI and neuroscience, culminating in research experiences in two neuroscience labs. Transitioning into healthcare, I witnessed firsthand the importance of patient advocacy and empathy, especially through the mentorship of [redacted] and my time in the ER. My commitment to patient care extends to diverse populations, including those with mental health issues and disabilities. Finally, my involvement with [visually impaired volunteering] taught me the value of autonomy and trust, qualities I aim to embody as a future physician.
Personal: I run XC. I make music, guitar and piano mainly, but lately a lot of musescore and audacity. I have an absolutely terrible I like learning languages. I’ve been learning chinese (B2) for 7 years, Japanese (C1) for almost 6, Korean (B1) for 5, French (B1) for 3, heritage speaker of 2 Indian languages, and with my CARS score I’m not sure if I can claim English lmao. I’ve tutored at a non-profit the basics in Japanese, Chinese, and Korean for 150 Hrs, wrote a self-published book about constructed languages, was invited to present the book at an international conference, and recently passed the Japanese Language Proficiency Test so I can “officially” speak Japanese 😎. Languages and different cultures are a very big part of my life.
School List: Notes: I would like to stay in Massachusetts, but if I have to pull a slipping Jimmy and enroll at the University of American Samoa, so be it. Tear my list to shreds. I really want to match into a surgical specialty, so only US MD.
In-State: UMass BU Tufts Harvard
OOS: Dartmouth Vermont Brown Quinnipac UConn Yale Cornell Columbia NYMC Mount Sinai Stony Brook Einstein Hackensack Drexel Penn State JHU Sidney Kimmel TJU Georgetown George Washington U UVA Duke UNC Chapel Hill Vtech Wake Forest Stanford UCSF UCLA UWA Kaiser U of Hawaii (apparently Japanese is a thing in Hawaii)

In today's fast-paced world, maintaining metabolic health has become increasingly important. Recognizing this need, the Metabolic Wellness Program has emerged as a comprehensive solution aimed at enhancing overall well-being. This program leverages the Science of Living principles to offer a holistic approach to health and fitness, making it a standout option in the realm of metabolic health conditioning companies. Let's delve into what makes the Metabolic Wellness Program unique and how it can benefit you.
The Science of Living Approach
At the heart of the Metabolic Wellness Program lies the Science of Living, a concept that integrates physical, mental, and emotional health. This approach is not just about addressing metabolic issues but about fostering a balanced lifestyle that supports sustained wellness. The Science of Living emphasizes personalized health strategies that cater to individual needs, recognizing that each person's metabolic profile is unique.
Science of Living Bangalore: A Hub for Metabolic Health
One of the leading centers for the Metabolic Wellness Program is Science of Living Bangalore. This institution is renowned for its cutting-edge research and personalized wellness plans. Science of Living Bangalore combines traditional wellness practices with modern scientific insights to create effective health programs. Their team of experts includes nutritionists, fitness trainers, and wellness coaches who work together to tailor a program that suits your specific metabolic needs.
The Role of a Metabolic Health Conditioning Company
As a metabolic health conditioning company, the Metabolic Wellness Program goes beyond conventional health plans. It offers a structured pathway to improve metabolic function through various interventions. These include nutritional guidance, physical activity plans, stress management techniques, and regular health assessments. The goal is to optimize your body's metabolism, ensuring efficient energy use and better overall health.
Comprehensive Metabolic Consultation & Coaching
A key component of the Metabolic Wellness Program is its robust Metabolic Consultation & Coaching services. These services are designed to provide continuous support and guidance throughout your wellness journey. During a metabolic consultation, health experts assess your metabolic rate, body composition, and lifestyle habits. This thorough evaluation helps in identifying any metabolic imbalances and crafting a personalized action plan.
The coaching aspect of the program ensures that you have the support needed to implement and stick to your personalized plan. Coaches offer motivation, monitor your progress, and make necessary adjustments to your regimen. This dynamic approach ensures that you are always on the right track to achieving your metabolic health goals.
Benefits of the Metabolic Wellness Program
The benefits of enrolling in the Metabolic Wellness Program are numerous. Participants often experience increased energy levels, improved weight management, and enhanced mental clarity. By addressing the root causes of metabolic dysfunction, the program helps prevent chronic diseases such as diabetes, cardiovascular issues, and obesity. Moreover, the holistic nature of the program promotes overall wellness, including better sleep, reduced stress, and a more balanced lifestyle.
Conclusion
The Metabolic Wellness Program stands out as a leading solution for those seeking to enhance their metabolic health. By integrating the principles of the Science of Living and offering personalized care through Science of Living Bangalore, this program sets the standard for metabolic health conditioning companies. With comprehensive Metabolic Consultation & Coaching, it provides the tools and support needed to achieve and maintain optimal health. Whether you are looking to boost your energy, manage your weight, or improve your overall wellness, the Metabolic Wellness Program offers a scientifically-backed pathway to a healthier, more vibrant life.
More Information:
https://scienceofliving.fit/3rd Floor, 9th, A Main 559, 9th A Main Rd,1st Stage, Indiranagar, Bengaluru, Karnataka 560008Phone:+91-9886157784Email: info@scienceofliving.fit

Okay so, bit of backstory, in 2016 with my first pregnancy. I had my son preterm at 36 weeks as my water broke spontaneously on its own. Ended up with an emergency c-section as I laboured for 26 hours and when I finally reached 10cm, my son’s heart rate dropped too low and my blood pressure shot through the roof. (I was diagnosed with High blood pressure and was being suspected of Preeclampsia) thankfully my son and I both made it, we stayed in the hospital for 4 days after the c-section as my son was jaundice and but still feeding well on his own so he didn’t need the NICU, just stayed by my side throughout the whole hospital stay. Fast forward to now, currently 34 weeks 1 day, I’ve gotten diagnosed with gestational diabetes, cholestasis and am currently being tested for preeclampsia as my blood pressure rises from time to time. I came into the hospital at my hometown due to sudden pain and pressure throughout the day yesterday, had more discharge than I knew was normal. The doctor checked my cervix there and said I was still closed, the amniotic fluid swab was borderline green/blue. He said I had a UTI and because of my history of preterm labour, I got flown out to the city I am going to be delivering my baby girl at. I arrived in the city at 2am and 10am, my OB checked me and I was dilated to 2cm! I wasn’t dilated with my first when my water broke. I’m currently admitted for a few days to see if I’m gonna be dilating anymore, still lots of pressure going on but not painful. Just wanted to get it off my chest.

So my background… I’m prone to getting panic attacks, I have some xanax on hand for when those happen but it’s not terribly often. I do deal with anxiety in general though. I’ve tried to control it with cardio exercise and eating healthy and journaling but even then it isn’t enough sometimes. A few years ago I started getting panic attacks during cardio - it’s almost as if my body reacts to an elevated heart rate (like, around 130 or 140 bpm which is normal during cardio) by going into a fight or flight response mode. The first time it happened it really scared me and I stopped exercising, which was a detriment to my anxiety because I wasn’t exercising. I talked to my doctor and she gave me Zoloft 50mg which did help. Also wanted to mention that during that time I had just gone through a divorce and my mom also passed away. (So, it’s no surprise I was having anxiety) I also have essential hypertension, not due to weight or any kidney issues or heart issues, just due to genetics. I’m at a normal BMI like 22, not diabetic or anything like that. So I take a beta blocker and valsartan for the hypertension (and have for many years, I’m in my 40s). I don’t drink alcohol or use any illegal drugs. The Zoloft did help and I was on it for about a year in 2021/2022 but it made me feel flat, and low libido so I weaned off it without too much trouble, some brain zaps for a couple weeks but adjusted fine. Fast forward to this past year, I’m exercising again and still get the fight or flight physical reaction if I push too hard on the cardio, which I hate because it hinders my fitness. I also have started getting more anxiety, especially during my luteal phase (pretty much 2 weeks out of the month I feel like shit emotionally but the other 2 weeks I feel fantastic). I talked to my doctor and she gave me 25mg pristiq, because she said it has less effects of the flat feeling and low libido like Zoloft gave me. But I also see it can raise blood pressure for some people, which I already deal with hypertension (but it’s controlled with the beta blocker /valsartan). I’m also seeing a lot of issues here with people tapering off, which gives me pause in starting it. I’ve wondered if I should just try Zoloft again because I know how I’ll respond but I hate the low libido. I guess I’m just afraid/nervous about trying pristiq. Anyway I guess I’m not looking for any advice but it would be nice to hear other people’s thoughts. Thanks for reading this far.

Complete remission of depression and anxiety using a ketogenic diet: case series

Front. Nutr., 14 May 2024 Sec. Clinical Nutrition Volume 11 - 2024 https://doi.org/10.3389/fnut.2024.1396685
Background: There is little data that describe the use of ketogenic metabolic therapy to achieve full remission of major depression and generalized anxiety disorder in clinical practice. We present a retrospective case series of three adults with major depression and generalized anxiety disorder with complex comorbidity, treated with personalized ketogenic metabolic therapy, who achieved complete remission of major depression and generalized anxiety disorder and improvements in flourishing, self-compassion, and metabolic health.
Methods: Three adults, ages 32–36, with major depression, generalized anxiety, other anxiety disorders, and comorbid psychiatric conditions were treated for 12–16 weeks with personalized whole food animal-based ketogenic metabolic therapy (1.5:1 ratio) in a specialized metabolic psychiatry practice. Interventions included twice-weekly visits with an experienced ketogenic registered dietitian; daily photo journaling and capillary blood BHB/glucose/GKI monitoring; virtual groups; family/friends support; nature walks and talks several times per week, and community building. Successful adoption of the ketogenic diet was defined as the achievement and maintenance of capillary BHB ≥ 0.8 mmol/L and GKI < 6. Remission was assessed by GAD-7 and PHQ-9, and quality of life was assessed subjectively and with validated scales for flourishing and self-compassion. Metabolic health was assessed by laboratories/biometric measures.
Results: Two patients achieved remission of major depression (PHQ-9 ≤ 4) and generalized anxiety (GAD-7 ≤ 4) within 7 weeks of therapeutic nutritional ketosis; one required 12 weeks. Anxiety responded and remitted more quickly than major depression. Flourishing and self-compassion increased steadily. Patients lost 10.9 to 14.8% of their initial body weight within 12 weeks and improved metabolically; one achieved optimal metabolic health.
Conclusion: Complete remission of major depression and generalized anxiety disorder occurred within 7–12 weeks of therapeutic nutritional ketosis during treatment with a personalized animal-based ketogenic diet (ratio 1.5:1) in adults with complex comorbid depression and anxiety engaged in a specialized metabolic psychiatry program.

Introduction

Emerging brain-based research in psychiatry and neurology has focused on identifying fundamental metabolic disturbances within neurons and throughout the body involving insulin resistance, inflammation, oxidative stress, and alterations of the gut microbiome (1). All four of these fundamental metabolic disturbances are present in major depression (2), and underlying anxiety disorders (3) and can be directly modulated through the use of ketogenic metabolic therapy (KMT) (4).
As psychiatric disorders have risen over the past several decades, the prevalence of metabolic syndrome has sharply increased, with only 12.2% of U.S. adults meeting the criteria for optimal metabolic health, leaving 87.8% metabolically compromised (5, 6).
Metabolic syndrome affects almost a third of individuals with major depression (7). It is a significant contributor to their morbidity and mortality (8) and is rooted in impaired glucose metabolism and utilization. Insulin resistance has been well described in many tissues, including the brain (9), where it is being investigated as a link between metabolic health and mental health conditions. Preclinical models demonstrate that glucose intolerance is directly associated with anxiety and that insulin resistance triggers depressive behaviors (9). In brain tissue, insulin resistance results in cerebral glucose hypometabolism and a vicious cycle of unmet energy needs (10). In human studies, cerebral glucose hypometabolism is a feature of major depression (11, 12) and generalized anxiety disorder (GAD) (13).
KMT, also known as the therapeutic ketogenic diet, or KD, is a low carbohydrate, moderate-protein, high-fat diet that supports a fundamental metabolic shift from glucose to ketone bodies as the primary fuel source (14). Classic KMTs are formulated with strict macronutrient ratios, most commonly 4:1 and 3:1 (fat: protein + carbohydrates), and have demonstrated efficacy in intractable epilepsy and genetic disorders. More recently, modified classic KMTs with lower macronutrient ratios of 2.5:1, 2:1, and 1.5:1 have been utilized in research and clinical practice (15, 16). These allow more variety in the diet, meet micronutrient needs except vitamin D (17), and are easier to sustain for extended periods of time.
KMT exploits the body’s natural ability to produce ketone bodies (d-beta-hydroxybutyrate (BHB), acetoacetate, and acetone) in the liver from fatty acids by keeping carbohydrate consumption very low. Acute and sustained production of ketone bodies produces a fundamental shift in fuel energetics within cells, particularly neurons, which can radically re-route and quickly rely on readily available BHB and acetoacetate for cellular energy (18). Ketone bodies also increase vascular density at the blood–brain barrier, which can strikingly increase the availability of ketone bodies for brain energy metabolism by 40-fold (19). Ketones are a preferred energy source in the CNS (20) and neurons will choose ketones over glucose when available.
Nutritional ketosis (10) using a KMT is a natural, not pathological, state (21) where the body’s energy and protein synthesis needs are met with a high-fat/moderate-protein/low-carbohydrate diet, resulting in sustained elevations of serum ketones and fatty acids and normal glucose without acidemia. In both acute and long-term nutritional ketosis, ketone bodies have a number of biological effects that directly change the brain’s cellular energy status (15), increase mitochondrial density (22), and improve mitochondrial morphology, which has been shown to be altered in mood disorders (23, 24). Mitochondrial abnormalities have also been postulated to be responsible for changes in synaptic function and neuroplasticity, potentially associated with symptoms of depression and anxiety (19).
Recent research shows that a ketogenic diet (KD) reduces neuronal firing rates, modulates ion channels and cell signaling cascades, and stimulates the biochemical synthesis and neurotransmission of GABA by inhibiting glutamate decarboxylase, a major inhibitory neurotransmitter involved in neuronal firing and anxiogenesis (25, 26). BHB activates the transcription of antioxidant-related genes by inhibiting histone deacetylases, triggering long-term adaptive changes in gene expression. In addition, at physiologic concentrations, ketone bodies reduce neuroinflammation through direct action at G-protein coupled receptors (25). KD also favorably alters the gut microbiome (27). Perhaps most importantly, KD directly increases NAD+, which reduces reactive oxygen species and increases mitochondrial ATP production. It is also utilized as a substrate for sirtuins and PARP enzymes associated with DNA repair and longevity. A sustained increase in NAD+ may underlie the pleiomorphic benefits of KMT across multiple neuropsychiatric conditions (28). In terms of the frequent abnormal alarms set off in the amygdala during anxiety, nutritional ketosis may provide an acute and long-term intervention to reduce generalized anxiety, panic attacks, obsessive doubt, and symptoms of post-traumatic stress disorder (PTSD). For apathy, anhedonia, amotivation, and abulia seen in major depression, therapeutic nutritional ketosis may provide higher and more sustained intraneuronal energy and repair (29, 30).
There is no published data that describes the implementation and use of personalized KMT for adults in real-world clinical practice who present with major depression comorbid with GAD and complex psychiatric comorbidity.
The aim of this case series is to examine the response to the treatment of major depression and generalized anxiety with whole-food animal-based personalized KMT in adults with complex psychiatric comorbidity and varied metabolic status. We conducted a retrospective review of three cases from our Metabolic Psychiatry Registry that demonstrate a consistent response and remission of major depression and generalized anxiety among patients who are psychiatrically and metabolically complex, despite differences in the initiation and adoption of KMT, and varied metabolic dysfunction. We describe the evaluation process and prescription of KMT, baseline metabolic workup and monitoring, elements that fostered treatment engagement and adherence, and challenges encountered during 12 weeks of KMT. We correlated capillary BHB/GKI with time to the remission of major depression and GAD and the achievement of metabolic health.

Discussion

Although KD was first shown to produce antidepressant effects and alleviate “behavioral despair” in preclinical studies more than 20 years ago (20), there is little clinical data regarding KD in major depression and anxiety disorders.
A retrospective analysis of 31 individuals with primary diagnoses of major depression (N = 7), bipolar II disorder (N = 13), and schizoaffective disorder (N = 12) who had failed to respond to conventional psychiatric care was treated with KD (75%–80% fat, 15%–20% protein, 5% carbohydrate) for 12 weeks in a psychiatric hospital (31). Of these patients, 22 were voluntarily admitted for the initiation of KD, and the remainder were offered KD during their inpatient hospital course. Change in depression was measured by HAM-D and MADRS in 6 of 7 patients with major depression and 12 of 13 patients with bipolar disorder. Notably, 100% of patients given the HAM-D showed statistically significant improvement in depressive symptoms (mean HAM-D decreased from 25.4 to 7.7; mean MADRS decreased from 29.6 to 10.1). However, serum ketones were not measured; urinary ketone measures were obtained once in 28 patients during the 12-week intervention; 18 patients (64%) showed positive urine ketones (31).
Bipolar depression was included in a recent randomized controlled pilot study assessing the safety and feasibility of KMT as adjunctive therapy, and reported safety and feasibility with excellent adherence and maintenance of ketosis (mean BHB 0.88 ± 0.99 mmol/L for 12 weeks) (32).
One case report utilized KD (65% fat, 25% protein, 10% carbs) with a time-restricted feeding window in a 65-year-old woman with major depression and type II diabetes and reported remission of depression (PHQ-9 17 to 0), normalization of HbA1c, decrease in estimated average glucose from 216 to 96 mg/dL, improvement in HOMA-IR from 9.4 to 2.3, and TG/HDL ratio from 4.7 to 1.2 over 12 weeks. The only measured serum BHB reported in the case was a mean of 1.5 mmol/L by week 12 (30).
A recent meta-analysis of low carbohydrate diets used in controlled trials that evaluated symptoms of depression and anxiety, not disorders, in varied metabolic and inflammatory conditions reported that the symptomatic response of these symptoms was inconclusive (33). The conclusions may not apply to KMTs; the meta-analysis was limited by grouping varied diets with higher carb intake and higher protein intake than usually associated with diets formulated to induce nutritional ketosis; serum or capillary BHB was not reported; and primary and secondary outcomes varied across studies.
In anxiety, preclinical research shows that exogenous ketone supplementation reduces anxiety behaviors (34). There is one case report of a self-administered Atkins Diet for weight loss in a woman with panic disorder (35) but no reports of KMT in panic disorder, OCD, or PTSD. Case reports of KD addressing anxiety describe two cases of decreased anxiety symptoms in a woman with women, one with bipolar I disorder and another with unspecified mood disorder, comorbid emotional dysregulation, body dysmorphic disorder, and eating disorder (36, 37), and one case report that describes the elimination of anxiety symptoms in a man with bipolar disorder (38). Anxiety and obsessive preoccupations improved in weight-restored anorexic women, in one case report describing complete remission of anorexia (39) and in a retrospective case series where animal-based KD was adopted without dietary prescription and monitoring (2); however, ketone measures were not reported. One small pilot trial where KD was followed by ketamine infusions reported a significant lessening of obsessive preoccupations in weight-recovered women with chronic anorexia; here, ketosis was measured by breath acetone (40).
Finally, all three patients had comorbid ADHD, which may be important. Approximately 65–89% of adults with ADHD experience one or more comorbid psychiatric conditions, and ADHD often occurs comorbid with anxiety and depression (41). Preclinical studies in murine models (42) of ADHD with hyperactivity suggest that KD may improve symptoms via alteration of the gut microbiome. Preclinical studies in dogs with epilepsy displaying ADHD-like behaviors treated with a medium-chain triglyceride KD have shown decreased pathological behaviors (43). Further research exploring the effect of KMT in humans with ADHD should be considered to understand the mechanisms of action and assess short- and long-term risks and benefits.
There is little research regarding the selection, implementation, and treatment course for KMT use as adjunctive or sole treatment in individual psychiatric conditions. Given the potential benefits of therapeutic nutritional ketosis and the restoration of metabolic health (44), there is a pressing need to identify the biological underpinnings of KD in psychiatric disorders and delineate factors associated with the successful adoption and adherence of KMT and responses in common psychiatric disorders such as depression and anxiety. In clinical practice and real-world settings, where patients often present with multiple comorbidities, consideration of KD can seem daunting to clinicians.
Despite that, this case series illustrates complete remission of both major depression and GAD in three adults with complex psychiatric comorbidity and previously unrecognized metabolic dysfunction using whole-food, animal-based personalized KMT. Anxiety responded first and time to remission occurred rapidly within 7–12 weeks, despite varied challenges, including preferences for time-restricted eating, slow adoption, inconsistent monitoring, and emergent fatigue during strenuous exercise, which occurred many weeks into KMT due to low serum carnitine and spontaneous reduction of protein intake rather than keto-adaptation or “keto-flu.” All patients improved metabolically, and one patient achieved optimal metabolic health (6).
These patients were representative of many adults in clinical psychiatric practice who present with persistent, serious symptoms interfering with several life domains. They each had five DSM-V psychiatric disorders: severe unipolar major depression, GAD, at least one other anxiety disorder (OCD, PTSD, and/or panic disorder), and ADHD, and two had binge eating disorder. They had all failed at least two previous adequate trials of medications and psychotherapy and were seeking relief. All had family histories of mood and anxiety disorders and documented metabolic disease in first-degree relatives. Extensive laboratory testing and bioimpedance evaluations were eye-opening because, although they were overweight, they were not aware of the extent to which they were already metabolically ill; we suspect it enhanced their motivation to adopt and maintain KMT.
This case series is limited by describing only three patients, which limits the generalizability of our results as well as the inherent selection bias, as they were interested in KMT after failing standard therapies. In addition, they were selected because their complex psychiatric comorbidity reflects the complexity seen in the majority of our outpatient psychiatric practice. This degree of complexity may limit the generalization of these findings, although it is important to note that outpatient clinical psychiatric practice as a whole has seen an increase in complex psychiatric comorbidity over the past two decades (44).
As a retrospective case series, there may be additional limiting and confounding factors, including the lack of a control group. Some rating scales and digital data are missing, which may impact the completeness of the analysis. Time to consistent nutritional ketosis and delays in obtaining necessary labs requiring intervention may have contributed to a longer time to response and remission; response and remission may occur earlier than reported here, and this deserves further research. Finally, it is not clear to what extent immersive treatment (see Supplementary material 1) and additional interventions during KMT, such as close digital monitoring, frequent clinical contact, group supports, and nature walks, contributed to the rapidity of response/remission of anxiety and depression, or to overall treatment success, independent of the biological effects of KMT, and which of these elements were most critical; more research is needed. Carefully designed prospective studies and randomized controlled trials providing higher levels of evidence are needed to examine the use of KMT and time to response and remission in individuals without comorbidity and determine the extent to which comorbidity may confound or alter these (8).
As metabolic psychiatry moves forward, we need both preclinical and larger, well-controlled clinical studies examining the pleiomorphic effects of ketone bodies in the brain and in the body to understand how we can best leverage whole foods to optimize brain energy, enhance genetic expression, reduce neuroinflammation, optimize metabolic health, and safeguard the promise of our future.

Hello! RN here in Canada, I tried searching for info myself here before posting but came up with nothing.
My situation is that my family (parents, brother, wife, grandparents) are considering a trip back to home country in Europe, kind of a “last” trip possible for my grandparents (ln their late 80’s). They are both medically stable but will require clearance from their doctor, assistance with their health, diabetes, and care. I am wondering if it’s possible for me to get compensated for the care I provide on the trip via their health insurance (most health insurances have an amount for nursing care). How would I go about this? what is a fair rate? Is there documentation of care I would need to collect or submit to their insurance? Would there be issues since I’m a family member providing care?
Obviously I am also fine not getting paid for my services on this trip because it’s family and I would rather make the trip possible, but I am curious. Thank you in advance for replies!

Blood pressure at my doctor's office yesterday was 114/76.
It wasn't super high before, but it was creeping up and up and was sometimes borderline.
And it's funny because prior to starting ZB, my doctor had said, "For a 61-year-old obese woman, you're remarkably healthy."
And it's true. No diabetes or pre-diabetes, my cholesterol has sometimes been borderline, but I've never been on medication, I had a calcium scoring test (MRI) on my heart to detect blockages and my risk was rated as less than 5%. Meanwhile, my tall, thin husband has a much higher risk, is on Lipitor, and has flirted with diabetes in the past.
I suppose these markers could have worsened over time if I had continued to gain weight, and I am glad to be losing.
On a side note: for the last two weeks I took 5 mg compounded tirzepatide, didn't lose any weight, and didn't feel the same level of suppression or satiety, and had increased hunger and food noise. I didn't lose or gain any weight. It's not like it didn't work at all because I experienced some minor side effects that I associate with this medication and it's not like I had to hold myself back from a binge or white-knuckle it around certain kinds of foods. It was just different. I did notice that it was much easier to eat the amount of calories I am "supposed" to eat and even went over a tiny bit one day.
I was able to get a box of 5 mg Zepbound and I started back on it today and will be interested to see if anything changes.

CorMedix and DefenCath®
Cormedix (NASDAQ.NMS: CRMD) is a biopharmaceutical company that focuses on developing and commercializing therapeutic products for the prevention and treatment of infectious and inflammatory diseases. They particularly specialize in addressing unmet medical needs in the field of urology, with their lead product being DefenCath®, designed to prevent catheter-related bloodstream infections and related complications.
The company operates in the healthcare sector, specifically within the biotechnology and pharmaceutical industry.
With the recent approval of DefenCath® there arises a compelling growth opportunity within the biopharmaceutical industry, based on future sales of their proprietary drug.
Outstanding Growth Opportunity for CorMedix
Growth prospects come directly from the potential future sales for DefenCath®.
This drug is meant to reduce the incidence of catheter-related bloodstream infections in adult patients with kidney failure receiving chronic hemodialysis. According to the National Institute of Diabetes and Digestive and Kidney Diseases approximately 1 in 7 U.S adults suffer from chronic kidney disease. If we assume that only approximately 10% of that are currently receiving chronic hemodialysis, we are talking about a potential market of 4.76 Millions of US patients.
Lets assume a penetration rate of 10%. That means DefenCath would reach 476 thousand of US patients every year.
The frequency of chronic hemodialysis treatments are between 3 to 6 times per week.( In-Center Hemodialysis Six Times per Week versus Three Times per Week - PMC (nih.gov)) Now CorMedix has established its list price at 249.99 USD per 3ml vial, which is used per single treatment (so 3 to 6 vials per week).
If we assume 3 vials per week are used, the total potential sales at 10% penetration would be, approximately, 357 Millions of USD per year.
If we look at, for instance, (LEGN), Legend Biotech Corp ADR, which is currently valued at 8.32 USD Billions ( a multiple of 29 times their last 12M sales of 285M) and assume a similar valuation, this would take #CRMD to a valuation of approximately 10 USD Billions.
LEGN Revenue (SEC)
We’re currently sitting at a valuation of 314M, this would mean a 31X appreciation over current valuation, which would be close to a price tag of 176.7 USD per currently available share.
Disclaimer: This is not financial advice please do your own research before investing. I do have a long position in the shares of CRMD via stock and options ownership. I’m also not sponsored by any means to promote this stock in any way whatsoever.
TL;DR
You should look into CRMD and do your own research, it might indicate a good opportunity based on the potential future sales of their recently-approved proprietary drug.

Hello all!
I am 35, t1 diabetic since I was 10 and have so far resisted pumps as I don't like relying on tech due to anxiety about it failing. The Libre 2 changed my life, but with 1 in 2/3 sensors failing... I am all too aware of how stressful it is. I am also very slender and sensitive about things on my body so worry about site rotation, and also failure rates of the pump and how I would get a replacement.
I take a tiny amount of insulin a day, 4-5 units of slow acting split between morning and evening and the only time I bolus is for highs - usually a 0.5 unit.
I have a lot of historical hypo anxiety that has reawakened recently after some bad night time experiences and I am fed up of living in terror. Every time I inject I feel a sense of dread and fear, and it's making me too scared to properly correct highs.
I wonder if the pump might help alleviate some of my anxiety, specifically the ability to control small amounts of insulin and even suspend insulin.
I'm approaching a real state of high anxiety and burnout with this.
Does anyone have any thoughts?
Thank you so much.
EDIT: For context I am UK so would be prescribed on NHS

Hi everyone!
Today, let's talk about inflammation markers. Inflammation is your body's way of fighting off things like infections or injuries. However, if it sticks around too long, it can be a sign of something more serious. Two important blood tests that check for inflammation are the CRP test and the ESR test. Let’s break down what these tests are, what they measure, and why they matter.

What is Inflammation?

Inflammation is how your body responds to things like infections or injuries. It helps to heal and protect your body. But if inflammation lasts too long, it can cause health problems.

Key Inflammation Markers:

1. CRP (C-Reactive Protein)

• What It Measures: CRP is a protein made by your liver when there's inflammation in your body.
• Normal Range: Less than 10 mg/L.
• High Levels Mean: High CRP levels mean there’s inflammation, which could be from an infection, arthritis, or other conditions.

2. ESR (Erythrocyte Sedimentation Rate)

• What It Measures: ESR measures how quickly red blood cells settle at the bottom of a test tube. Faster settling means more inflammation.
• Normal Range: 0-22 mm/hr for men and 0-29 mm/hr for women.
• High Levels Mean: High ESR levels mean there’s inflammation, which could be due to infections, autoimmune diseases, or other conditions.

Why These Tests Matter:

• Early Detection: These tests can catch inflammation early, even before you feel sick.
• Monitor Conditions: They help doctors keep track of chronic (long-term) diseases.
• Guide Treatment: High levels can help doctors figure out what’s wrong and how to treat it.

Conditions with High Inflammation Markers:

1. Infections: Like bacterial or viral infections.
2. Autoimmune Diseases: Conditions where your immune system attacks your own body, like rheumatoid arthritis.
3. Chronic Diseases: Long-term conditions like heart disease or diabetes.
4. Cancer: Some cancers can cause higher inflammation.
5. Injury and Surgery: These can temporarily raise inflammation levels.

Tips for Reducing Inflammation:

1. Healthy Diet: Eat lots of fruits, veggies, whole grains, and lean proteins. Avoid junk food and too much sugar.
2. Exercise Regularly: Stay active to help lower inflammation.
3. Healthy Weight: Keep a healthy weight to reduce inflammation.
4. Manage Stress: Try to relax with activities like meditation or yoga.
5. Avoid Smoking and Limit Alcohol: Both can increase inflammation.
6. Get Enough Sleep: Aim for 7-9 hours of sleep each night.

When to Get Tested:

• Symptoms: If you have unexplained fever, tiredness, joint pain, or swelling.
• Chronic Conditions: If you have a long-term inflammatory disease, get tested regularly.
• Check-Ups: Get tested during routine health check-ups if you have risk factors for chronic diseases.

Conclusion:

Understanding CRP and ESR tests can help you and your doctor spot and manage health issues early. Keeping inflammation in check with a healthy lifestyle can improve your overall health. If you have any questions or want to share your experiences with inflammation markers, leave a comment. Your story could help someone else.
Stay healthy and informed!

Introduction
When blood sugar levels cannot be controlled with oral medications alone, human insulin is used to treat type 1 diabetes, a condition in which the body does not produce insulin and cannot control blood sugar levels, or type 2 diabetes, a condition in which the body does not produce or use insulin normally, resulting in excessive blood sugar levels. Human insulin belongs to a group of drugs known as hormones. The insulin that the body naturally produces is replaced with human insulin. It functions by assisting the body's other tissues in transferring blood sugar, which is used there for energy. It also prevents the liver from generating additional sugar. This is how all of the available forms of insulin function. The only differences between the insulin kinds are in how soon they start to act and how long they stay effective at regulating blood sugar.
What is Gestational diabetes ?
For women without a history of diabetes, gestational diabetes is a form of the diabetes that can develop during pregnancy. After the baby is born, gestational diabetes typically disappears. If your doctor advises differently, it's crucial to get a follow-up glucose tolerance test six to twelve months after the baby is born or before attempting a second pregnancy to ensure you are no longer diabetic.You can increase the likelihood of a successful pregnancy and healthy baby by controlling your gestational diabetes.
Who is susceptible to gestational diabetes?
The prevalence of gestational diabetes in pregnant women ranges from 3% to 8%. In most cases, it is discovered between 24 and 28 weeks, though it might appear earlier. Receiving a gestational diabetes diagnosis might be distressing and unanticipated. It's critical to receive support and assistance in controlling it by reaching out.
Gestational diabetes is more likely to affect some women. Among the women in this category are these:

• are overweight or obese
• have a family history of type 2 diabetes
• are older than 40 years of age
• use some steroids or antipsychotic drugs.
• having experienced gestational diabetes in the past
• previously given birth to a child weighing more than 4,500 grams.
• having experienced a difficult pregnancy in the past
• have PCOS, or polycystic ovarian syndrome.

There are some pregnant women without established risk factors for gestational diabetes.
Education about the use of insulin
It is critical that you receive guidance and support on the administration, storage, and operation of insulin from your physician or diabetes educator.
It is crucial that you understand the warning signs and symptoms of hypoglycemia, how to manage it, and the safe blood glucose levels for driving. Insulin can occasionally cause blood glucose levels to drop too low.
What happens after the birth of a baby?
After your baby is born, you normally stop injecting insulin to help manage gestational diabetes. This is due to the fact that after giving delivery, women's blood glucose levels typically recover to the ideal range rather quickly.
It's crucial to check your baby's blood glucose levels after birth to make sure it hasn't dropped too low. If so, you can cure it by giving your child formula or breast milk. It is advised that you breastfeed your child because it is best for both of you.
After your baby is delivered, your blood glucose levels will be monitored for a few days to make sure they are within the appropriate range. It is customary to check blood sugar two hours after eating and before breakfast. Six to twelve weeks after the baby is born, an oral glucose tolerance test (OGTT) is performed to see if your diabetes has resolved.
If you live in a high-risk location or are unable to socially distance yourself from the pathology center, it is advised that you postpone the OGTT testing for a period of six months during COVID-19. If you intend to become pregnant again or before your child turns 12 months old, it is advised to have an OGTT. Follow your physician's advice.
Although a child whose mother had gestational diabetes won't have diabetes at birth, they might have a higher chance of type 2 diabetes in the future.
What side effects can insulin cause?
There may be adverse effects from human insulin. Inform your physician in the event that any of these symptoms worsen or persist:

• Skin thickening (fat build-up)
• Skin redness
• Swelling
• Itching at the injection site
• A small depression in the skin (fat breakdown)
• Constipation
• Weight gain

Certain adverse effects may be dangerous. Give your doctor a call right away if you encounter any of the following symptoms:

• Rash and/or itching throughout the entire body
• Dyspnea
• Wheezing
• Lightheadedness
• Hazy vision
• Rapid heart rate
• Perspiration Weakness in breathing or swallowing
• Muscles Cramps
• Irregular pulse
• Significant weight gain
• Edema of arms, hands, feet, ankles, or lower legs

Conclusion
Insulin therapy is still the recommended course of treatment for uncontrolled gestational diabetes mellitus (GDM) and type 1 and type 2 diabetes. The insulins with the greatest human pregnancy data are NPH, insulin lispro, insulin aspart, and regular insulin. Clinicians' ability to accurately weigh the advantages and disadvantages of modifying insulin therapy will become increasingly important. It's also crucial to share the data with the patient so she can help choose the optimal insulin dosage. For the greatest fetal results, strict glycemic control must be maintained throughout pregnancy, regardless of the regimen selected.

​

Chronic Fatigue Syndrome (CFS)

Chronic fatigue syndrome (CFS), often known as ME/CFS, has a broad spectrum of symptoms that persist a long period. It is determined by basic signs and criteria. Post-exertional malaise (PEM), substantial impairment in capacity to accomplish tasks that were typical before the illness, and sleep issues are some of the key symptoms of Chronic fatigue syndrome (CFS) .
Orthostatic intolerance (difficulty sitting and standing) and cognitive issues. Long-lasting discomfort and a broad spectrum of body systems are also frequent symptoms.
The reason is unknown, however it might be due to metabolic, genetic, viral, or physical or psychological stress. For lack of a universal diagnostic test, the diagnosis is figured by symptoms.
A person with CFS becomes weary from working hard, and it doesn't get better when they rest. Many conditions cause fatigue, but none cause the amount of tiredness and functioning issues found in CFS.
Many individuals with CFS may improve with time, but many will remain unwell and incapacitated for a long period. No authorised therapies or medications for the underlying cause. Instead, treatment aims to alleviate distressing symptoms.
The CDC (Centers for Disease Control and Prevention) recommends pacing (personal activity management) to prevent symptoms from worsening. Some patients may benefit with Rinatolimod (a medication intended for treatment of chronic fatigue syndrome ), psychotherapy, and tailored activity management, however research is limited.
It affects 1% of persons who see their doctor regularly, although the figure fluctuates since epidemiological studies define the disorder differently. According to official estimates, CFS affects 836,000-2.5 million Americans and 250,000-1,250,000 Britons.
Women have CFS at a rate of 1-2% higher than males. Most individuals acquire it between 40 and 60. Even youngsters may be affected. The prevalence of CFS in children is unknown, however it is thought to be about 0.5 percent. One of the most prevalent reasons students miss class is chronic fatigue syndrome.
CFS affects one's health, happiness, and productivity, as well as loneliness and alienation. However, several aspects of the illness remain unclear. Disability is diagnosed and treated by doctors, researchers, and others. The evidence for the causes and therapies isn't always consistent.

Common Symptoms

The CDC (Centers for Disease Control and Prevention) proposes the following diagnostic criteria for unwell people:

• Ability to perform things before the sickness. Weariness follows a decline in activity. It must last six months.
• Symptoms worsen if you do anything little before the condition. Exercise may make you sick, and the symptoms generally appear 12 to 48 hours later. Some term it a "crash," although it might last a long time. Also known as Post-exercise malaise (PEM).
• Sleep problems make it difficult to remain awake, fall asleep, or stay asleep.
• Memory and reasoning are poor (cognitive dysfunction, sometimes described as "brain fog")
• Standing or sitting upright may cause dizziness, weakness, fainting, or visual issues (orthostatic intolerance)

While other common symptoms may occur that not all ME/CFS people report
People who have a cold or the flu can have pain in their muscles, joints, and neck or armpits.
People who have a sore throat, irritable bowel syndrome, a cold, or night sweats, as well as people who have allergies and sensitivities to food and other things, can have a hard time breathing.

Functional Capacity of a Chronic Fatigue Syndrome Diagnosed Patient

People with Chronic Fatigue Syndrome can accomplish many things. Many individuals with CFS live regular lives, while others are bedridden and unable of self-care. Most CFS patients must miss job, school, and family time for a lengthy period.
Men and women have the same symptoms and limitations, and many suffer from severe chronic pain. Inactivity is blamed for this. The complexity of things has also changed.
AIDS causes as much agony and anguish as lupus, rheumatoid arthritis, COPD, and end-stage renal failure. Even while major conditions like multiple sclerosis, congestive heart failure, or type 2 diabetes exist, CFS has a greater effect on a person's capacity to function and well-being.
Symptoms go in and out of remission, making treatment difficult. People who feel better may overexert themselves, causing worsening symptoms and relapse of their disease. A percent of persons with CFS are permanently housebound or bedridden for years. An illness that prevents around 75% of them from working.
More over half of them were on disability or sick leave, and just a fifth worked full-time. Children with CFS are the major cause for absenteeism.
The quality-of-life questionnaire found that patients with CFS had reduced "vitality," "physical functioning," "general health," "physical role," and "social functioning." However, CFS patients' "role emotional" and "mental health" subscales were identical to or slightly lower than healthy people's. Every year, the US spends a lot of money on healthcare.

Cognitive Dysfunction of a Chronic Fatigue Syndrome Diagnosed Patient

Cognitive Dysfunction is one of the most devastating aspects of CFS, affecting people's ability to work and interact. It's estimated that 50-80% of CFS sufferers experience cognitive issues. Problems with attention, memory, and reaction time are typical cognitive symptoms.
Measured cognitive abilities are lacking, which may impair everyday living. For example, they make more errors, forget things, and have problems responding when spoken to.
In addition, activities requiring long-term working memory are slower. These defects generally support up the patient's views. As far as I can see, your ability to move swiftly, think clearly, and talk clearly hasn't altered.
People with poor health were more likely to report cognitive issues. People with CFS who could accomplish more physically had less visual perception and language processing issues.
Several reasons may be at play when it comes to disparities between what individuals claim they are and what they really are. It's difficult to compare participants' cognitive capacities before and after illness since there aren't any measures that accurately evaluate CFS's distinctive cognitive impairments.
CFS patients have higher neuropsychiatric and cognitive symptoms than non-CFS patients. The cause is unclear. Many theories exist to explain why cognitive symptoms and illness coexist.
Some experts believe psychological factors contribute to or cause the disease. Others believe the sickness generates physiological and social changes that manifest as symptoms.

Therapies Known to Have Worked with Chronic Fatigue Syndrome

The CDC says talking to a therapist may help patients cope with their conditions. Counseling and behavioural treatments may benefit some patients, but they may not enhance their quality of life, according to a 2015 NIH analysis.
This means that these treatments should not be utilised alone, but rather as part of a larger strategy. The same article claims that therapy may help with weariness, function, and overall improvement. However, these methods have been understudied in several CFS patient subgroups. Those who had psychotherapy or behavioral treatment reported few unpleasant side effects.
IOM 2015 study indicates it's unclear whether Cognitive Behavioral Therapy (CBT) assists persons with cognitive disorders. It's unclear why CBT is used to help patients feel better about their illness. A 2014 research found little indication that CBT participants were more active.
The authors claim that those who received CBT were adjusting to the condition rather than improving.
Patient organisations have long opposed CBT as a CFS treatment. Also questioned is the model's explanation The MEA studied 493 CBT patients in the UK in 2012.
Due to the findings of this research, the MEA concluded in 2015 that CBT should not be the principal therapy for CFS. There's a "false model of causality," says Dr. Charles Shepherd, a MEA medical adviser. This paradigm ignores the wide range of clinical manifestations and illness processes that fall within the ME/CFS umbrella.
A 2019 research of ME/CFS patients in the UK revealed that CBT didn't help for over half of them, and that Graded Exercise Therapy made most individuals worse.